CN103861041B - A kind of Chinese medicine composition for the treatment of acute and chronic rhinitis and preparation method thereof - Google Patents
A kind of Chinese medicine composition for the treatment of acute and chronic rhinitis and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition and preparation method thereof, particularly a kind of Chinese medicine composition for the treatment of acute and chronic rhinitis and preparation method thereof.Chemotherapeutic agent liver toxicity for current acute and chronic rhinitis is larger, the prior art of unsatisfactory curative effect is not enough, the Chinese medicine composition that a kind for the treatment of or prevention acute and chronic rhinitis are provided of the present invention, it comprises following component: Fructus Forsythiae 10-50 part, Flos Carthami 10-20 part, Rhizoma Curcumae Longae 5-20 part, Radix Cynanchi Paniculati 5-15 part, Radix Rehmanniae 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Poria? 1-10 part, Fructus Lycii 5-15 part, Herba Ephedrae 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Radix Ophiopogonis 0.2-9 part, Rhizoma Polygoni Cuspidati 5.5-15 part, Caulis Spatholobi 6-9 part, Radix Glycyrrhizae 10-15 part.This Chinese medicine composition all has good therapeutic effect in treatment or prevention acute and chronic rhinitis, and drug side effect is low, has significant clinical generalization value.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of acute and chronic rhinitis and preparation method thereof.
Background technology
Rhinitis is due to virus, courses of infection, or the nasal membrane caused under the effect of stimulus object and submucosal chronic inflammatory disease.Clinical manifestation is nasal membrane swelling, secretions increase, headache, giddy etc.More than course of disease periods of months or recurrent exerbation.Rhinitis causes producing too much mucus, usually the symptom such as watery nasal discharge, nasal obstruction is caused, cause mucosa, tela submucosa, even the limitation of periosteum and bone or Diffuse fibrous hamartoplasia, plump, concha nasalis inferior is the most obvious, and its front and back end and lower edge can become nodositas, Fructus Mori shape or lobulated plumpness, also can there is hypertrophy in middle nasal concha front end and nasal septal membrane, plump or Polypoid changes.The research nearest by the U.S. shows, is patients with rhinitis more than 5,000 ten thousand Americans.Do not treat for a long time, rhinitis also can affect the sleep quality of people, audition and learning capacity.Also can cause antibacterial and be stayed in nasal cavity for a long time and amount reproduction, and then cause flu.Flu inflammation long-term existence then increases the weight of Rhinitis Symptoms.Rhinitis Chinese medicine belongs to nasal sinusitis category.The heresy that its etiology and pathogenesis mostly is the heresy or wind and cold experiencing wind heat enters inner heat-transformation, and the turbid tears resistance of pyretic toxicity is closed nose key and formed.Chronic person is many because of deficiency of the spleen and lung, insufficiency of lung-QI to weakened defensive QI, susceptible exopathogen.Insufficiency of the spleen then transformation failure of spleen, phlegm-damp is detained, and tired knot nose key, contamination sinus mucosa forms nasal sinusitis.At present, the Western medicine for the treatment of acute and chronic rhinitis is a lot, but most drug therapeutic effect is poor, and treats into the shortcomings such as high, side effect is large in addition, even affects patient health time serious.Clinical treatment of rhinitis is primary and secondary effect mainly with intranasal Decongestant (agent of oxymetazoline nasal spray ephedrine hydrochloride nasal drops), glucocorticoid is to produce rebound phenomenon, even occurs even more serious nasal obstruction, to the hypertrophy that long-term rhinitis produces, and plump less effective.And Chinese medicine rhinitis curative effect is reliable, toxic and side effects is little, has broad prospects.But mostly adopt Fructus Xanthii Flos Magnoliae etc., feature has certain drug toxicity, can not long-term taking, and also long-term effect is undesirable, and large for nasal drop local irritation, curative effect is of short duration.Namely the object of the invention is to provide a kind of effect comprehensively, the Chinese medicine composition of the treatment acute and chronic rhinitis that clinical effectiveness is good.
Make a general survey of the research direction of world's new drug, the eighties mainly researched and developed single chemicals and preparation thereof in the past, and start after the eighties to develop biotechnology and natural medicinal plants, drug research direction is tending towards multiformity.In conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, reducing the angle of side effect, through carrying out to Chinese medicine ingredients the preparation that screening is extracted and/or compatibility is obtained, its side effect is little, and safety is high, has the advantage that chemical synthetic drug can not be compared.
Summary of the invention
Large in order to overcome existing acute and chronic rhinitis chemotherapeutic agent toxic and side effects, the prior art that acute and chronic rhinitis therapeutic effect is difficult to continue is not enough, the invention provides a kind of Chinese medicine composition for the treatment of acute and chronic rhinitis, this Chinese medicine composition good effect, side effect is little, it obtains primarily of following raw material: Fructus Forsythiae 10-50 part, Flos Carthami 10-20 part, Rhizoma Curcumae Longae 5-20 part, Radix Cynanchi Paniculati 5-15 part, Radix Rehmanniae 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Poria 1-10 part, Fructus Lycii 5-15 part, Herba Ephedrae 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, Radix Ophiopogonis 0.2-9 part, Rhizoma Polygoni Cuspidati 5.5-15 part, Caulis Spatholobi 6-9 part, Radix Glycyrrhizae 10-15 part.
Fructus Forsythiae is that Chinese Clinical commonly uses one of Chinese medicine, has another name called Hemerocallis citrina Baroni bar, Fructus Forsythiae, green grass or young crops stick up, falls to sticking up, Huang Qidan etc.Pharmacopoeia of the People's Republic of China version in 2005 Fructus Forsythiae recorded is Oleaceae (Oleaceae) Forsythia (Forsythia) plant Fructus Forsythiae (Forsythiasuspensa(Thunb.) Vahl) dry fruit, fruit just ripe gathering when still band is green is called that green grass or young crops sticks up, and gathers to be called and always to stick up during the well-done yellowish of fruit.The Fructus Forsythiae pharmacological action such as have antibacterial, heart tonifying, diuresis, town to tell, the diseases such as the conventional acute anemopyretic cold of forsythia fruit for treating, carbuncle sore tumefacting virus, tuberculous lymphadenitis, urinary tract infection are the primary raw material of the Chinese medicine preparation such as two chuanxiong rhizome oral liquid, two Rhizoma Chuanxiong power injection, QINGRE JIEDU KOUFUYE, even careless antipyretic oral liquid, flos ionicerae and fructus forsythiae infusion for detoxication.
Flos Carthami main chemical compositions comprises saffloside, Flos Carthami wakes up glycosides, Flos Carthami polysaccharide, Palmic acid, cinnamic acid, there is vasodilative effect, coronary resistance can be reduced, increase coronary artery blood flow, improve cardiac muscle nutritional blood flow, have anti-doubtful blood and anti-thrombosis function, can excited uterus, low dose makes uterus that Rythmic contractions characteristic occur, and heavy dose makes uterus muscle convulsion love, and can reduce the blood lipid level such as cholesterol in serum and triglyceride.Its function comprises: promoting blood circulation to remove obstruction in the collateral, eliminating stasis to stop pain, and for amenorrhea, dysmenorrhea, lochia, WEIJIA mass in the abdomen, injury from falling down, skin ulcer pain swells and ache.
Rhizoma Curcumae Longae: its rhizome medicinal, bitter in the mouth is pungent, warm in nature, returns liver, spleen two warp.Main component such as, containing volatile oil, Rhizoma Curcumae Longae essence, dehydrogenation Rhizoma Curcumae Longae essence, zingiberene etc.Rhizoma Curcumae Longae can declare the gas in logical blood, makes gas capable and blood is not stopped up stagnant, and has effect of inducing menstruation to relieve menalgia.Rhizoma Curcumae Longae can increase bile and be formed and secretion, and the cholic acid drained in feces and cholesterol are increased.Although Rhizoma Curcumae Longae promotes that the effect of bile secretion is more weak, more lasting.Rhizoma Curcumae Longae can also increase fibrinous lytic activity, has antithrombotic effect.Find according to pharmacological research, Rhizoma Curcumae Longae has the effect in excited uterus, and can make uterine contraction, pregnant woman is cautious use of.
Large doctors and patients portion otch, part vertebral plate and articular process excision, or the capable discectomy of inter-laminar space.The main chemical compositions of Radix Cynanchi Paniculati comprises C21 steroid, cynapanoside, Bai wei glycosides, there is analgesic activity, sedation, can coronary artery blood flow be reduced, improve myocardial metabolism, alleviate myocardial ischemia, has effect for reducing blood fat, and prevention of arterial is atherosis, to staphylococcus aureus, escherichia coli, bacterium sonnei, bacillus pyocyaneus has inhibitory action.Its function comprises: sedation-analgesia, wet removing toxic substances, rheumatic arthralgia, headache, toothache, and traumatic injury is dizzy, skin eczema, snake bite and insect sting.The traditional Chinese medical science thinks that Bulbus Lilii has the effect of nourishing the lung to arrest cough, clearing away heart-fire for tranquillization, and especially fresh Bulbus Lilii is more sweet delicious.Bulbus Lilii is particularly suitable for foster lung, the people of nourishing the stomach eats, such as the patient of chronic cough, pulmonary tuberculosis, aphtha of the mouth and tongue, xerostomia, halitosis.Bulbus Lilii not only has good nutritious tonifying effect, and for the patient such as deficient syndrome, tuberculosis, neurosis is of great advantage after being ill, has good curative effect to various cancer.In the prevention and therapy of tumor, Bulbus Lilii is used for treatment pulmonary carcinoma, nasopharyngeal carcinoma, skin carcinoma etc.During the symptoms such as the body void occurred after carrying out radiotherapy to above-mentioned cancer is weak, xerostomia, vexed, dry cough expectorant, cook congee together with Semen oryzae sativae with fresh Bulbus Lilii, edible after calling in appropriate crystal sugar or Mel again, to the reaction of health invigorating, anticancer growth, alleviation radiotherapy, there is good effect.For another example, fresh Bulbus Lilii and white sugar are smash deposited affected part in right amount altogether, infiltration person hemorrhage to skin carcinoma ulceration also has certain therapeutical effect.
Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have infection effect to old man and child.So, often take Flos Lonicerae soak or decoct be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.
Poria, is commonly called as Poria, Song Ling, Poria, and for colonizing in the fungi plant on pinaster root, shape is as Rhizoma Dioscoreae esculentae, and crust pitchy, the inside is white or pink.Ancients claim Poria to be " when four god medicine ", because its effect widely, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, wet all diseases, can play its unique effects.Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Fructus Lycii (formal name used at school: Lyciumchinense) is the multi-branched shrub plant of Solanaceae Lycium, and high 0.5-1 rice, can reach more than 2 meters during cultivation.All there is distribution both at home and abroad.Fructus Lycii whole body is precious, and bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is recorded: " spring adopts Folium Lycii, name sky essence grass; Summer picks flowers, name Sempervivum tectorum; Qiu Caizi, name Fructus Lycii; Dong Caigen, name Cortex Lycii ".Fructus Lycii tender leaf also known as Fructus Lycii head, edible or make Fructus Lycii tea.Modern study, Fructus Lycii has reduction blood glucose, lipotropy, and can antiatherogenic effect.
Herba Ephedrae has diaphoresis cold expelling, depressed lung-energy dispersing, effect of inducing diuresis to remove edema.Clinical in anemofrigid cold, uncomfortable in chestly to breath with cough, edema due to wind pathogen edema; Bronchial asthma.Herba ephedrae nourishing the lung to arrest cough.Be used for table disease to separate, the diseases such as asthma and cough.Modern pharmacology shows, and ephedrine has antifatigue effect to skeletal muscle, can promote by curare conduction between the neuromuscular that suppresses, can be used for the treatment of myasthenia gravis; Also hyperglycemia can be caused, but its effect is more weak and non-constant.Ephedrine and Herba Ephedrae total alkaloids all do not show perspiration to normal and heating cat, and in the ordinary course of things, ephedrine can not bring out perspiration to people.
The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.The pungent temperature rise of this product is fallen apart, and all hyperactivity of YANG due to deficiency of YIN and excessive rising of liver-YANG person should not apply; Menorrhagia, anemia of pregnant woman also avoid use.
The Radix Angelicae Dahuricae, warm in nature, acrid in the mouth is micro-sweet, has expelling wind and removing dampness; Logical surreptitiously pain relieving; Effect of detumescence and apocenosis.Main headache due to common cold; Supraorbital bone pain; Toothache; Nasal obstruction; Nasal sinusitis; Domination of damp pathogen chronic diarrhea; Women leucorrhea; Ulcer sores; Venom.Clinical in headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.Also can be used for the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis.Control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Rhizoma Atractylodis have drying damp and strengthening spleen, expelling wind and cold, effect of improving eyesight, and for dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.Control dampness taste, and see the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur, the normal and compatibility such as Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae is applied.
Radix Ophiopogonis, having another name called Radix Ophiopogonis, is Liliaceae Ophiopogon plant.Radix Ophiopogonis is used as medicine with tuber.Nature,taste and action: sweet, micro-hardship, cool, Yin-nourishing and body fluid promoting, nourishing the lung to arrest cough, clear away heart-fire relieving restlessness.Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry pharynx lung-heat, cough, pulmonary tuberculosis.
Rhizoma Polygoni Cuspidati: its root medicinal, slightly warm in nature, tool promoting blood circulation to restore menstrual flow, dampness removing function, is conventionally used to treatment rheumatism, arthralgia pain, jaundice, amenorrhea, dysmenorrhea etc.Prove according to modern pharmacological research, Rhizoma Polygoni Cuspidati, containing anthraquinone analog compound and flavonoid Multiple components, can extract the polydatin etc. with component for reducing blood fat in acting in accordance with YIN YANG changes in four seasons stem.Regarding assay proves, Rhizoma Polygoni Cuspidati has the effect reducing cholesterol and triglyceride.
Caulis Spatholobi: be the rattan of pulse family Climbing Plant spatholobus suberectus, Millettia dielsiana, evergreen mucuna etc.Someone thinks that this medicine comes from supplementary Amplifications of the Compendium of Materia Medica, but examines the description of its plant with different now.Its name that really name conforms to reality comes from Qing Dynasty Wang Ang essentials of Matea Medica, and other Herbal Textuals is also loaded with the another name such as " Radix seu Caulis Verntilaginis Leiocarpae ", " Caulis seu Radix Schisandrae Henryi ".Some area as northeast, northwest, Central-South the rattan of Lardizabalaceae liana Caulis Sargentodoxae (namely Caulis Sargentodoxae, Caulis Sargentodoxae, aftermentioned) is used as Caulis Spatholobi, Caulis Spatholobi is used as the rattan of Magnoliacea plant Kadsura heteroclita and middle Fructus Schisandrae Chinensis in Yunnan.Just logical Caulis Spatholobi main product Guangxi, Guangdong, property bitter but sweet flavor temperature, return Liver Channel, promoting the circulation of blood is had to enrich blood, regulating menstruation, the effects such as relaxing muscles and tendons and activating QI and blood in the collateral, can treat that the gynaecopathia such as menoxenia, blockage of menstruation, dysmenorrhea, blood deficiency amenorrhea and rheumatic arthralgia, numb hand and foot, limbs are weak and limp, blood deficiency dull yellowish colored skin etc., and controlling leukopenia also has certain curative effect.
Chinese medicine composition of the present invention with except long-pending numbness, dispersing wind and cold, wind-damp dispelling, bone and muscle strengthening are for main standard, has significant antiinflammatory, analgesia and activating blood circulation to dissipate blood stasis effect after Chinese medicine composition combination of the present invention on Chinese medicinal components is selected.The parts by weight of the present invention to above-mentioned all taste Chinese medicine carry out preferably, preferred condition be after drug matching uses medicine to the enhancing of acute and chronic rhinitis therapeutic effect.As a preferred embodiment of the present invention, Chinese medicine composition of the present invention obtains primarily of the raw material of following weight portion: Fructus Forsythiae 30 parts, 15 parts, Flos Carthami, 15 parts, Rhizoma Curcumae Longae, Radix Cynanchi Paniculati 10 parts, 8 parts, the Radix Rehmanniae, Bulbus Lilii 10 parts, Flos Lonicerae 10 parts, 6 parts, Poria, Fructus Lycii 10 parts, 12 parts, Herba Ephedrae, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 10 parts, Radix Ophiopogonis 5.5 parts, Rhizoma Polygoni Cuspidati 10 parts, Caulis Spatholobi 8 parts, 12 parts, Radix Glycyrrhizae.
Preferably, Chinese medicine composition of the present invention also contains the Radix Aucklandiae 7 parts further, the Cortex Eucommiae 5 parts, Radix Polygalae 9 parts.Radix Aucklandiae acrid in the mouth, hardship, warm in nature; Return spleen, stomach, liver, large intestine channel, fragrance row is loose, can rise and can fall.It has following effect: promoting the circulation of QI to relieve pain, for the abdominal distention caused by stagnation of QI in spleen and stomach, lack of appetite vomiting; Regulate the flow of vital energy soothing the liver, for the hypochondriac pain that QI stagnation of the liver and galibladder causes.Spleen invigorating disappears stagnant, the stagnant gas of adjustable gastrointestinal.Treatment stomachache, diarrhoea, tenesmus.The main chemical compositions of the Cortex Eucommiae comprises multiple lignanoid, Phenylpropanoid Glycosides and iridoid, there is hypotensive activity, reuse and can produce toleration, can excited pituitary adrenal system function, improve the phagocytic function of peritoneal macrophage, the immunosuppressive action of hydrocortisone can be resisted.Its function comprises: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive, lumbago due to renal deficiency, and muscles and bones is unable, and pregnant morning leaks blood, frequent fetal movement, hypertension.Radix Polygalae is conventional Chinese medicine, be recorded in Shennong's Herbal the earliest, be classified as top grade, and be regarded as supporting life key medicine, warm in nature, bitter in the mouth, pungent, the function of there is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
In order to express Chinese medicine composition of the present invention better, Chinese medicine composition of the present invention can be prepared into dosage form conventional clinically.Such as, the preparation such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule.Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into powder, water preparation, tablet or capsule.
Present invention also offers a kind of preparation method of Chinese medicine composition described above, it mainly comprises following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, the alcoholic solution that volumetric concentration is 40%-95% is doubly added according to the 4-9 of coarse powder gross weight, reflux, extract, three times, return time is 2-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically, as tablet, capsule etc. in this preparation method.
The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment acute and chronic rhinitis medicine.Pharmaceutical composition of the present invention, when treating acute and chronic rhinitis, demonstrates significant anti-inflammatory and antalgic, activating blood circulation to dissipate blood stasis is active.Test examples 19 of the present invention shows, and compares with model group, low middle high three the dosage groups of Chinese medicine composition of the present invention all can significantly reduce dimethylbenzene induced mice ear swelling value (
p< 0.01), show that Chinese medicine composition of the present invention has the effect of the mice ear significantly suppressing dimethylbenzene induction, and there is significant dose-effect relationship to the reduction effect of ear swelling in it.Under same experiment condition, positive control drug Biyan Ning capsule group also significantly reduce ear swelling value (
p< 0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.Test examples 20 of the present invention shows, mice licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the incubation period that the mice of each administration group of Chinese medicine composition of the present invention adds foot reaction is all greater than model group, there is dose-dependence, and be significantly greater than the incubation period of high dose group model group (
p< 0.05).What illustrate that this Chinese medicine composition of the present invention can extend that mice stimulates hot plate adds the sufficient response latency, has certain analgesic activity.Under same experiment condition, positive control drug Tongqiao Biyan capsules group (
p< 0.05) and Biyan Ning capsule group (1h,
p< 0.05; 2h,
p< 0.01) also significant prolongation mice add the incubation period of foot reaction, have certain analgesic activity.Test examples 21 of the present invention shows, and model group compares with normal control, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase (
p< 0.05).Compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high all significantly or pole significantly reduce the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein high dose there were significant differences (
p< 0.05).Under same experiment condition, positive control drug Tongqiao Biyan capsules group also reduces whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as Chinese medicine composition of the present invention.The result statistics display of liver index, model group compares with normal control, and liver index significantly increases.And compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high significantly reduce liver index (
p< 0.01), positive control drug Tongqiao Biyan capsules and Chinese medicine composition of the present invention Chinese medicine composition high dose group of the present invention can reduce significantly liver index (
p< 0.05), but effect is not as good as Chinese medicine composition of the present invention.Embodiment 22 result shows, Chinese medicine composition of the present invention all has good fungistatic effect to most pathogenic entero becteria, this shows that the acute and chronic rhinitis that Chinese medicine composition of the present invention causes for various bacteria or fungus all has significant therapeutic effect, can play the effect for the treatment of both the principal and secondary aspects of a disease to infectious acute and chronic rhinitis.And more estimable, containing plurality of active ingredients in Chinese medicine composition of the present invention, many for target spot during acute and chronic rhinitis treatment of infection, not easily produce drug resistance, be significantly better than existing clinical in widely used antibiotics.
In a word, pharmaceutical composition of the present invention, in treatment acute and chronic rhinitis, compared with prior art has following advantage:
1) compared with positive control drug Tongqiao Biyan capsules or Biyan Ning capsule, pharmaceutical composition Chinese medicine composition of the present invention not only antiinflammatory and ease pain more remarkable, and also significantly positive drug is better than in activating blood circulation to dissipate blood stasis, this shows that the present composition has significant synergism in acute and chronic rhinitis treatment, significantly can not only improve the symptom of acute and chronic rhinitis, the development of acute and chronic rhinitis can also be delayed, contribute to the recovery process of acute and chronic rhinitis patient;
2) compared with the chemotherapeutic agent of Current therapeutic acute and chronic rhinitis, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, particularly it does not produce any destruction for intestinal mucosa, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, significantly improves the compliance of acute and chronic rhinitis patient, and improves the quality of life of patient;
3) existing antibiotic medicine acute and chronic rhinitis initial therapy effect still can, but all occur obvious drug resistance problem along with the prolongation for the treatment of time, its therapeutic effect for acute and chronic rhinitis declines.Containing multi-medicament component in Chinese medicine composition of the present invention, action target spot is numerous, efficiently solves the Commpensation And Adaptation of acute and chronic rhinitis medicine, and it does not decline because treatment time extends to the therapeutic effect of acute and chronic rhinitis.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
part I Chinese medicinal composition preparation of the present invention, preparation and using method thereof
embodiment 1-6 Chinese medicine composition composition powders
table 1 Chinese medicine composition composition powders of the present invention prescription
Embodiment 1 preparation method: get each medical material in compositions, conveniently technique grinds to form powdery, cross 100 mesh sieves, little fire drying is for subsequent use, obtains powder.During use, directly take after mixing it with water with after water dissolution.Embodiment 2-6 preparation method is with embodiment 1.
embodiment 7-12 Chinese medicine composition water preparation
table 2 Chinese medicine composition water preparation of the present invention prescription
Embodiment 7 preparation method: get each medical material in prescription, conveniently decocting for Chinese herbal medicine technological operation, filtering medicinal residues and get final product.When this water preparation is used for acute and chronic rhinitis treatment, daily 2-3 time.Embodiment 8-12 preparation method and using method are with embodiment 7.
embodiment 13-18 Chinese medicine composition tablet/capsule of the present invention
table 3 Chinese medicine composition tablet of the present invention/capsule prescription
Embodiment 13 preparation technology: each traditional Chinese medicine powder getting recipe quantity is broken into coarse powder, adds according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 80%, reflux, extract, three times, the each 3h of return time, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; By Chinese medical concrete drying, pulverize and make dried cream powder, add customary adjuvant components utilising prior art and be prepared into tablet or capsule.
Embodiment 14-18 preparation technology is with embodiment 13.
part II Chinese medicine composition pharmacodynamic study of the present invention
embodiment 19 Chinese medicine composition xylol of the present invention causes the impact of mice ear
Get healthy ICR mice 72, ♀ ♂ half and half, divide 6 groups, 12/group, i.e. model group, Tongqiao Biyan capsules (Chuan great West China, Sichuan Pharmaceutical, lower same), Biyan Ning capsule group (production of Quanzhou, Fujian Province Luo Shangshan pharmaceutical factory), Chinese medicine composition of the present invention (obtaining by Chinese medicine composition prescription described in embodiment 1 and preparation technology) low dose group, middle dosage group and high dose group.Every ig administration 1 time/d; Administration 14d, 60min after last medicine, mouse right ear uniform application dimethylbenzene 0.03mL/ only causes swollen, cuts ears and beat auricle and weigh after 2h, calculates ear swelling value (mg).Swelling value=auris dextra weight-left ear weight.
Result show, compare with model group, low middle high three the dosage groups of Chinese medicine composition of the present invention all can significantly reduce dimethylbenzene induced mice ear swelling value (
p< 0.01), show that Chinese medicine composition of the present invention has the effect of the mice ear significantly suppressing dimethylbenzene induction, and there is significant dose-effect relationship to the reduction effect of ear swelling in it.Under same experiment condition, positive control drug Biyan Ning capsule group also significantly reduce ear swelling value (
p< 0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.
the impact of table 4 Chinese medicine composition xylol of the present invention induced mice ear swelling (
)
Note: compare with model group, *
p< 0.05, * *
p< 0.01.
embodiment 20 Chinese medicine composition of the present invention affects mouse hot-plate analgesic
1 mouse hot-plate pain model makes
About body weight 20g female mice is placed on hot plate dolorimeter, screen qualified ♀ mice 90 (to lick metapedes time < 5s or > 30s to throw aside, scald for preventing foot, also deadline should be established, be generally 60s), the incubation period of metapedes reaction is added for threshold of pain index with mice, get 72 jennies, be divided into 6 groups, 12/group, i.e. model group, Tongqiao Biyan capsules, Biyan Ning capsule group, Chinese medicine composition of the present invention (obtaining by Chinese medicine composition prescription described in embodiment 1 and preparation technology) low dose group, middle dosage group and high dose group.Each group is gastric infusion, and 1 times/day, dosage is as shown in table 5, and after successive administration 14d, after measuring last medicine, 60min, 120min add the time of foot reaction.
chinese medicine composition of the present invention is on the impact of licking the foot response latency in mouse hot-plate analgesic experiment
Mice licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the incubation period that the mice of each administration group of Chinese medicine composition of the present invention adds foot reaction is all greater than model group, there is dose-dependence, and be significantly greater than the incubation period of high dose group model group (
p< 0.05).What illustrate that this Chinese medicine composition of the present invention can extend that mice stimulates hot plate adds the sufficient response latency, has certain analgesic activity.Under same experiment condition, positive control drug Tongqiao Biyan capsules group (
p< 0.05) and Biyan Ning capsule group (1h,
p< 0.05; 2h,
p< 0.01) also significant prolongation mice add the incubation period of foot reaction, have certain analgesic activity.The results are shown in Table 5.
table 5 mice lick foot response latency timetable (
)
Note: compare with model group, *
p< 0.05, * *
p< 0.01.
embodiment 21 Chinese medicine composition of the present invention is to the improvement result of rat blood stasis models
Get healthy SD rat, body weight 180-200g, 70, male and female half and half, be divided into 7 groups at random by body weight: Normal group, model group, Tongqiao Biyan capsules group, Biyan Ning capsule group and basic, normal, high group of Chinese medicine composition of the present invention (obtaining by Chinese medicine composition prescription described in embodiment 1 and preparation technology), often organize 10.Gastric infusion, successive administration 14 days, Normal group and model group are to 0.5%CMC, and all the other give corresponding medicine, and dosage is as shown in table 7.Administration the 13rd day, 14 days, except Normal group, all the other treated animals press 1mg/Kg subcutaneous injection adrenalin hydrochloride, 2 times/day, interval 4h, and after first time injection, animal is put into 15min in 4 DEG C of frozen water by 2h.Administration is got 4-5ml blood anticoagulant heparin on the 15th day and is measured blood rheology parameter, gets liver and to weigh conversion organ coefficient.
Result shows, and model group compares with normal control, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase (
p< 0.05).Compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high all significantly or pole significantly reduce the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein high dose there were significant differences (
p< 0.05).Under same experiment condition, positive control drug Tongqiao Biyan capsules group and Biyan Ning capsule group also reduce whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as Chinese medicine composition of the present invention.The result statistics display of liver index, model group compares with normal control, and liver index significantly increases.And compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high significantly reduce liver index (
p< 0.01), positive control drug Tongqiao Biyan capsules and Chinese medicine composition of the present invention Chinese medicine composition high dose group of the present invention can reduce significantly liver index (
p< 0.05), but effect is not as good as Chinese medicine composition of the present invention.
table 6 Chinese medicine composition of the present invention on the impact of rat blood stasis models lectin from hemolymph (
)
Note: compare with normal control, #
p< 0.05, ##
p< 0.01; Compare with model group, *
p< 0.05, * *
p< 0.01.
table 7 Chinese medicine composition of the present invention on the impact of rat blood stasis models liver coefficient (
)
Note: compare with normal control, ##
p< 0.01; Compare with model group, *
p< 0.05, * *
p< 0.01.
Claims (2)
1. treat the Chinese medicine composition of acute and chronic rhinitis for one kind, it is characterized in that, described Chinese medicine composition is obtained by the raw material of following weight portion: Fructus Forsythiae 30 parts, 15 parts, Flos Carthami, 5 parts, Rhizoma Curcumae Longae, Radix Cynanchi Paniculati 5 parts, 10 parts, the Radix Rehmanniae, Bulbus Lilii 15 parts, Flos Lonicerae 10 parts, 10 parts, Poria, Fructus Lycii 10 parts, 10 parts, Herba Ephedrae, Rhizoma Chuanxiong 10 parts, the Radix Angelicae Dahuricae 10 parts, Radix Ophiopogonis 9 parts, Rhizoma Polygoni Cuspidati 15 parts, Caulis Spatholobi 6 parts, 10 parts, Radix Glycyrrhizae, the Radix Aucklandiae 7 parts, the Cortex Eucommiae 5 parts and Radix Polygalae 2 parts.
2. the Chinese medicine composition for the treatment of acute and chronic rhinitis as claimed in claim 1, is characterized in that: described Chinese medicine composition is powder, water preparation, tablet or capsule.
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| CN201610073895.0A CN105597011A (en) | 2014-03-25 | 2014-03-25 | Method for preparing traditional Chinese medicine composition for treating acute or chronic rhinitis |
| CN201410113223.9A CN103861041B (en) | 2014-03-25 | 2014-03-25 | A kind of Chinese medicine composition for the treatment of acute and chronic rhinitis and preparation method thereof |
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| CN201610073895.0A Withdrawn CN105597011A (en) | 2014-03-25 | 2014-03-25 | Method for preparing traditional Chinese medicine composition for treating acute or chronic rhinitis |
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| CN104666952B (en) * | 2015-02-15 | 2016-03-02 | 侯明月 | A kind of Chinese medicine composition for the treatment of chronic rhinitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1306840A (en) * | 2000-01-30 | 2001-08-08 | 刘朝兵 | Chinese medicine for treating acute and chronic rhinitis and nasosinusitis |
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| CN102274395A (en) * | 2010-06-10 | 2011-12-14 | 张天良 | Traditional Chinese medicine for treating rhinitis |
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| CN1306840A (en) * | 2000-01-30 | 2001-08-08 | 刘朝兵 | Chinese medicine for treating acute and chronic rhinitis and nasosinusitis |
Non-Patent Citations (1)
| Title |
|---|
| 鼻窦炎中医用药规律探讨;夏锦平;《中国中西医结合耳鼻咽喉科杂志》;19941231;第2卷(第1期);33-34 * |
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| CN105535864A (en) | 2016-05-04 |
| CN103861041A (en) | 2014-06-18 |
| CN105597011A (en) | 2016-05-25 |
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