CN105748846A

CN105748846A - Traditional Chinese medicine preparation for treating anemic heart disease and preparation method of traditional Chinese medicine preparation

Info

Publication number: CN105748846A
Application number: CN201610286438.XA
Authority: CN
Inventors: 朱宝敏
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-05-04
Filing date: 2016-05-04
Publication date: 2016-07-13

Abstract

The invention provides a traditional Chinese medicine preparation for treating an anemic heart disease and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises the following raw material medicines: herba chloranthi serrati, solanum xanthocarpum, paulownia kawakamii, polygala arillata roots, smilacina japonica, musa basjoo, rauvolfia verticillata, ervatamia hainanensis, carduus nutans, diospyros rhombifolia, ulmus pumila, lycopodium obscurum, cyathula root, clematis chrysocoma, argyreia pierreana, gardenia, clematis ranunculoides, michelia alba, dchisandra propingua, spatholobus sinensis, schisandra propinqua, melasma arvense and stems of false tomentoseanther clematis. The traditional Chinese medicine preparation provided by the invention is capable of treating the anemic heart disease with the combination of normal Western medicines, is convenient to take, good in treatment effect, free of toxic or side effect or adverse reaction, and simple in preparation process.

Description

A kind of Chinese medicine preparation treating anemic cardiopathy and preparation method thereof

Technical field

The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation treating anemic cardiopathy and preparation method thereof.

Background technology

Anemic cardiopathy (AnemicHeartDisease) refers to and causes hemoglobin (HB) by a variety of causes < chronic anaemia of 70g/L causes cardiac output to increase, cardiac enlargement or cardiac insufficiency.During chronic severe anemia, there is regression degeneration in cardiac muscle long term hypoxia, makes exercise tests hypofunction.Severe anemia makes blood oxygen carrying capability be decreased obviously, and to each system of body for hypoxgia, thus cardiac output increases, and cardiac load increases the weight of.Although cardiac output increases relevant with blood viscosity decline, blood flow acceleration and cardiac contractile force enhancing, but is mainly the increase of heart rate and stroke volume.The increase of pulse output again with arteriolar dilatation around, peripheral resistance decline closely related, so peripheral resistance reduce, be high kinemic principal element.Owing to cardiac output increases, body circulation is shunk pressure and is kept normal, so Ventricular work done all substantially increases, Ventricular expands and plump.Lasting cardiac output increase necessarily causes cardiac insufficiency.

The weight of clinical symptoms depends on the order of severity of anemia, the factors such as speed, persistent period, cardiovascular reserve capabillity occurs.Except general anemia symptom, the normal had palpitation of patient, tired, breathe hard, the disease such as dyspnea after fatigue, occasionally can there is angina pectoris.Health check-up can have the enhancing of sinus tachycardia, cardiac dilatation, apex beat, apical region of heart audible and 2～3 grades of systole blowing murmurs, water-hammer pulse etc..

When hemoglobin is lower than 40g/L, patient may occur in which paroxysmal dyspnea, orthopnea, pulmonary edema sign, and heart substantially expands, gallop rhythm, two, Tricuspid valve systolic murmur and apical region of heart diastolic murmur.Also the sign of congestion of systemic circulation can be caused.Show as distension of jugular vein, hepatomegaly, lower limbs edema, dropsy of serous cavity etc..

Summary of the invention

The technical problem to be solved is in that, utilizes the theory of Chinese medical science that China is traditional, it is provided that a kind of determined curative effect and the Chinese medicine preparation for the treatment of anemic cardiopathy free of toxic effects and preparation method thereof.

In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine preparation treating anemic cardiopathy, described Chinese medicine preparation includes following raw medicinal material: Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Fructus solani xanthocarpi, Catalpa ovata G. Don wood, Radix polygalae arillatae, Radix et rhizoma smilacinae japonicae, Pericarpium Musae Sapienti, Radix Rauvolfiae, Radix Ervatamiae Hainanensis, Herba Cardui Crispi, Radix seu Ramulus Diospyroris rhombifoliae, Cortex Ulmi virgatae, Herba Lycopodii Obscuri, Radix Cucubali, Herba Clematidis loureirianae, Cortex Hibisci, Flos micheliae Albae, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii, Schisandra glaucescens Diels., Radix seu Caulis Schisandrae Sinensis, Herba Melasmatis arvensis and Caulis Clematidis pseudopogonandrae.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15～25 parts, Fructus solani xanthocarpi 20～30 parts, 15～30 parts of Catalpa ovata G. Don wood, Radix polygalae arillatae 25～35 parts, Radix et rhizoma smilacinae japonicae 30～40 parts, Pericarpium Musae Sapienti 15～25 parts, Radix Rauvolfiae 20～35 parts, Radix Ervatamiae Hainanensis 25～40 parts, Herba Cardui Crispi 10～20 parts, Radix seu Ramulus Diospyroris rhombifoliae 25～35 parts, Cortex Ulmi virgatae 20～30 parts, Herba Lycopodii Obscuri 15～25 parts, Radix Cucubali 15～30 parts, Herba Clematidis loureirianae 20～35 parts, Cortex Hibisci 30～40 parts, Flos micheliae Albae 15～25 parts, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 20～30 parts, Schisandra glaucescens Diels. 5～15 parts, Radix seu Caulis Schisandrae Sinensis 10～20 parts, Herba Melasmatis arvensis 25～35 parts and Caulis Clematidis pseudopogonandrae 20～30 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15～20 parts, Fructus solani xanthocarpi 25～30 parts, 20～25 parts of Catalpa ovata G. Don wood, Radix polygalae arillatae 30～35 parts, Radix et rhizoma smilacinae japonicae 35～40 parts, Pericarpium Musae Sapienti 20～25 parts, Radix Rauvolfiae 25～30 parts, Radix Ervatamiae Hainanensis 30～35 parts, Herba Cardui Crispi 15～20 parts, Radix seu Ramulus Diospyroris rhombifoliae 30～35 parts, Cortex Ulmi virgatae 20～25 parts, Herba Lycopodii Obscuri 15～20 parts, Radix Cucubali 20～25 parts, Herba Clematidis loureirianae 25～30 parts, Cortex Hibisci 35～40 parts, Flos micheliae Albae 15～20 parts, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 20～25 parts, Schisandra glaucescens Diels. 10～15 parts, Radix seu Caulis Schisandrae Sinensis 15～20 parts, Herba Melasmatis arvensis 25～30 parts and Caulis Clematidis pseudopogonandrae 20～25 parts.

The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 16 parts, Fructus solani xanthocarpi 28 parts, 21 parts of Catalpa ovata G. Don wood, Radix polygalae arillatae 35 parts, Radix et rhizoma smilacinae japonicae 36 parts, Pericarpium Musae Sapienti 25 parts, Radix Rauvolfiae 27 parts, Radix Ervatamiae Hainanensis 34 parts, Herba Cardui Crispi 17 parts, Radix seu Ramulus Diospyroris rhombifoliae 35 parts, Cortex Ulmi virgatae 22 parts, Herba Lycopodii Obscuri 19 parts, Radix Cucubali 22 parts, Herba Clematidis loureirianae 29 parts, Cortex Hibisci 37 parts, Flos micheliae Albae 18 parts, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 21 parts, Schisandra glaucescens Diels. 15 parts, Radix seu Caulis Schisandrae Sinensis 17 parts, Herba Melasmatis arvensis 28 parts and Caulis Clematidis pseudopogonandrae 21 parts.

When the dosage form of described Chinese medicine preparation is oral liquid, its preparation method comprises the following steps:

The first step, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Fructus solani xanthocarpi, Catalpa ovata G. Don wood, Radix polygalae arillatae, Radix et rhizoma smilacinae japonicae, Pericarpium Musae Sapienti, Radix Rauvolfiae, Radix Ervatamiae Hainanensis, Herba Cardui Crispi, Radix seu Ramulus Diospyroris rhombifoliae, Cortex Ulmi virgatae and Herba Lycopodii Obscuri are mixed in proportion, with the methanol that determining alcohol is 70%～80% as solvent, adopt percolation with the speed slowly percolation of 1～3ml per minute, collecting percolate, concentrating under reduced pressure also dries, it is thus achieved that dry cream, being ground into powder, the quality of affiliated methanol is 4～6 times of first step mixture quality；

Second step, is mixed in proportion surplus stock medical material, is ground into powder；Add the distilled water relative to the powder quality 4～6 times obtained, decoct 2～4 hours, filter, it is thus achieved that the first filtrate；Filtering residue is added the distilled water relative to its quality 2～4 times, decocts 1～3 hour, filter, it is thus achieved that the second filtrate；Merging the first filtrate and the second filtrate, concentrate away the water of 2/3～3/4 volume, adding determining alcohol is the ethanol of 90～95%, makes determining alcohol reach 70%～80%, stands 20～30 hours, filters, concentrating under reduced pressure, dry, it is thus achieved that dry cream, is ground into powder；

3rd step, the powder mixing that the first step and second step are obtained, add the distilled water relative to powder quality 3～5 times amount, the sucrose of 0.2～0.4 times, the sodium benzoate of 0.01～0.02 times, stirring, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

When the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:

The first step, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Fructus solani xanthocarpi, Catalpa ovata G. Don wood, Radix polygalae arillatae, Radix et rhizoma smilacinae japonicae, Pericarpium Musae Sapienti, Radix Rauvolfiae, Radix Ervatamiae Hainanensis, Herba Cardui Crispi and Radix seu Ramulus Diospyroris rhombifoliae are mixed in proportion, add relative to the alcohol reflux that mixture 3～5 times amount determining alcohol is 55%～65% 2～4 times, each 2～3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3～5 times amount water, boils 2～4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；

3rd step, the mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；

4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01～0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；

5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 1～3: 0.15～0.3.

Beneficial effects of the present invention: the Chinese medicine preparation associating conventional western medicine treatment anemic cardiopathy of the present invention, easy to use, therapeutic effect is better, has no side effect and untoward reaction, and preparation technology is simple.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation treating anemic cardiopathy, Chinese medicine preparation includes following raw medicinal material: Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Fructus solani xanthocarpi, Catalpa ovata G. Don wood, Radix polygalae arillatae, Radix et rhizoma smilacinae japonicae, Pericarpium Musae Sapienti, Radix Rauvolfiae, Radix Ervatamiae Hainanensis, Herba Cardui Crispi, Radix seu Ramulus Diospyroris rhombifoliae, Cortex Ulmi virgatae, Herba Lycopodii Obscuri, Radix Cucubali, Herba Clematidis loureirianae, Cortex Hibisci, Flos micheliae Albae, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii, Schisandra glaucescens Diels., Radix seu Caulis Schisandrae Sinensis, Herba Melasmatis arvensis and Caulis Clematidis pseudopogonandrae.

The pharmacology of various raw medicinal materials is as follows:

Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae): [another name] Chloranthus japonicusSieb., four eclampsia, four watts, big Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), red Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), four leaves yellow.[source] medical material Ji Yuan: for the herb of Ofthe Primulaceae Herba lysimachiae Paridiformis.[nature and flavor] are pungent；Bitter；Warm in nature.[function cures mainly] expelling wind and removing dampness；Promoting blood circulation and stopping pain；Cough-relieving；Removing toxic substances.Main rheumatalgia；Epigastric pain；Cough；Traumatic injury；Furuncle and phyma treats skin ulcer；Venom.[extracts] " China's book on Chinese herbal medicine "

Fructus solani xanthocarpi: [another name] yellow fluid eggplant, Huang open up brokenly bowl, Solanum aculeatissimum Jacq., Radix solani coagulantis fruit, big bitter pill, an ancient musical pipe eggplant, Radix Solani Torvi head, yellow fruit Corallium Japonicum Kishinouye, spur.[source] medical material Ji Yuan: for the root of plant of Solanaceae Fructus solani xanthocarpi, fruit and seed.[nature and flavor] bitter in the mouth；Pungent；Warm in nature.[function cures mainly] wind-damp dispelling；Repercussive pain relieving.Main air pain of dampness syndrome；Toothache；Testis kind pain；Carbuncle furuncle.[extracts] " China's book on Chinese herbal medicine "

Catalpa ovata G. Don wood: [source] medical material Ji Yuan: for the root bark of moraceae plants Catalpa ovata G. Don wood, leaf.[function cures mainly] clearing away heat-damp and promoting diuresis；Promoting blood circulation and stopping pain.Main damp and hot dysuria；Diarrhoea；Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix polygalae arillatae: [another name] gold ovum, Flos Osmanthi Fragrantis rock holder, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), little pocket, kwan-yin fall seat, Bao Sulian, Flos Caraganae Franchetianae.[source] medical material Ji Yuan: for the root of milk wort pocket Radix Polygalae Wattersii.[nature and flavor] are sweet；Micro-hardship；Flat.[function cures mainly] eliminates the phlegm dehumidifying；Qi-restoratives spleen invigorating；Mind calming is invigorated blood circulation.Main cough with copious phlegm；Rheumatic arthralgia；Urine leaching pain；Edema；Beriberi；Hepatitis；Pulmonary tuberculosis；Puerperal asthenia；Inappetence；Infantile malnutrition；Insomnia and dreamful sleep；Menoxenia；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Radix et rhizoma smilacinae japonicae: [another name] Rhizoma Bergeniae scopulosae, inclined seven, Eriocheir sinensis seven, white Rhizoma et Radix Diphylleiae, Rhizoma Rhodiolae kirilowii, mountain broom corn millet.[source] medical material Ji Yuan: for rhizome and the root of liliaceous plant Radix et rhizoma smilacinae japonicae and pipe flower Radix et rhizoma smilacinae japonicae.[nature and flavor] sweetness and bitterness；Temperature.[return through] liver；Kidney channel.[function cures mainly] kidney invigorating and YANG supporting；Blood circulation promoting and blood stasis dispelling；Wind-expelling pain-stopping.Main impotence due to deficiency of the kidney；Menoxenia；Partially, aching all over the head；Rheumatic arthralgia；Carbuncle sore tumefacting virus；Traumatic injury.[each discussion] 1, " Shaanxi Chinese herbal medicine ": analgesia of dispeling the wind, fill blood, strengthening bone and muscle.Being in harmony headache, migraine, rheumatalgia, menoxenia, consumptive disease is hindered.2, " Chinese herbal medicine is commonly used in Tibet ": tonifying YANG kidney tonifying, the activating blood circulation method stasis of blood, except rheumatalgia, it is in harmony sexual impotence, traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Pericarpium Musae Sapienti: [source] medical material Ji Yuan: for the peel of Musaceae plant plantain etc..[nature and flavor] sweet in the mouth；Puckery；Cold in nature.[function cures mainly] heat-clearing and toxic substances removing；Blood pressure lowering.Main dysentery；Cholera；Skin pruritus；Hypertension.[each discussion] " Guangdong Chinese medicine ": take orally and control dysentery.Fried and decocted water clothes, controlled cholera belly pain.Decoct washing skin trace (scabies) to itch.[extracts] " China's book on Chinese herbal medicine "

Radix Rauvolfiae: [another name] taberpsychine, mountain Horse hoof, Fructus Linderae Glaucae, rauwolfia, false Fructus Capsici, fish gallbladder wood, Radix clematidis ranunculoidis, drug for incised wound.[source] medical material Ji Yuan: for the root of apocynaceae plant Radix Rauvolfiae.[nature and flavor] are bitter；Micro-pungent；Cool in nature.[function cures mainly] heat clearing away；Blood pressure lowering；Allay excitement.Main cold, fever；Headache body pain；Laryngopharynx swelling and pain；Hypertension；Dizziness；Insomnia.[each discussion] 1, " Nanning City's medicine will ": bring down a fever, antiinflammatory, plant urine, resisting hypertension.Control calentura eruptive syndrome, headache.2, " Guangxi Chinese medicinal herbal ": eliminating pathogen in the liver pathogenic fire reducing.Control hypertension, headache, wind heat eruptive disease.[extracts] " China's book on Chinese herbal medicine "

Radix Ervatamiae Hainanensis: [another name] only son and heir wood, taberpsychine tree, Ai Jiaoqing, thunder-crash bomb, chicken feet flower.[source] medical material Ji Yuan: for root or the leaf of apocynaceae plant Ervatamia hainanensis.[nature and flavor] are bitter；Pungent；Cool in nature.[return through] liver；Stomach；Large intestine channel.[function cures mainly] heat-clearing and toxic substances removing；Blood pressure lowering；Reducing swelling and alleviating pain.Main hypertension；Laryngopharynx swelling and pain；Rheumatic arthralgia；Traumatic injury；Carbuncle furuncle；Venom.[each discussion] 1, Guangzhou army " conventional Chinese herbal medicine handbook ": detoxicating and resolving stagnation of pathogens, wind-expelling pain-stopping.Control laryngopharynx swelling and pain, mastitis, rheumatalgia, traumatic injury, cold syndrome of the stomach pain, hypertension.2, Guangzhou air force " conventional Chinese herbal medicine handbook ": heat-clearing and toxic substances removing, eliminating stagnation sore-throat relieving.Control hypertension complicated headache, dysentery.[extracts] " China's book on Chinese herbal medicine "

Herba Cardui Crispi: [another name] flies gently, sky shepherd's purse, fly Phasiana, wood standing grain, Herba Cardui Crispi Artemisia, Semen astragali sinici, thorn are beaten the grass, Thunder God dish.[source] medical material Ji Yuan: for feverfew silk hair Herba Cardui Crispi and the herb or the root that save hair Herba Cardui Crispi.[nature and flavor] mildly bitter flavor；Cool in nature.[function cures mainly] dispels the wind；Heat clearing away；Dampness removing；Cooling blood for hemostasis；Promoting blood circulation and detumescence.Main cold cough；Headache dizziness；Urinary system infection；Chyluria；Leucorrhea；Jaundice；Rheumatic arthralgia；Spit blood；Epistaxis；Hematuria；Menorrhagia；Dysfunctional uterine hemorrhage；Traumatic injury；Furuncle furuncle and phyma；Swelling and pain of hemorrhoid；Burn.[each discussion] " Chinese herbal medicine is commonly used in Tibet ": removing heat from blood, hemostasis, dissipating blood stasis for subsidence of swelling.Control various hemorrhage, traumatic injury congestive edema, malignant boil, burn, scald.[extracts] " China's book on Chinese herbal medicine "

Radix seu Ramulus Diospyroris rhombifoliae: [another name] milk Fructus Kaki, Flos Caryophylli Fructus Kaki, have month in and month out, branch Fructus Kaki, fist Lee, top Buddhist monk, glutinous rice thorn, bitter Lee.[source] medical material Ji Yuan: for root or the branch of Ebenaceae plant Radix seu Ramulus Diospyroris rhombifoliae.[nature and flavor] are bitter；Property is put down.[return through] Liver Channel.[function cures mainly] clearing away damp-heat；Profit liver and gall；Blood circulation promoting and blood stasis dispelling.Main acute icterohepatitis；Liver cirrhosis；Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Cortex Ulmi virgatae: [another name] Radix Ulmi Tonkinesis.[source] medical material Ji Yuan: for the bark of Ulmaceae hair elm.[nature and flavor] are bitter；Puckery；Property is put down.[function cures mainly] blood circulation promoting and blood stasis dispelling；Hemostasis and pain-relieving.Main fracture；Traumatic pain；Traumatic hemorrhage；Gastrointestinal hemorrhage；Hematuria.[extracts] " China's book on Chinese herbal medicine "

Herba Lycopodii Obscuri: [another name] is beautiful then, cypress, Herba Lycopodii pulcherrimi, chromium tail Lycopodium casuarinoides Spring, Herba Lycopodii, Lycopodium casuarinoides Spring in thousand.[source] medical material Ji Yuan: for the herb of lycopsid Herba Lycopodii Obscuri Lycopodium clavatum.[nature and flavor] acid；Temperature；Nontoxic.[return through] lung；Kidney channel.[function cures mainly] expelling wind and removing dampness；Channels sootheing and network vessel quickening；Blood circulation promoting and blood stasis dispelling.Main air pain of dampness syndrome；Lumbago and skelalgia；Numb limbs and tense tendons；Osteopatia sprain；Poliomyelitis sequela.[each discussion] " not Lu ": QI invigorating, quenches the thirst.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Radix Cucubali: [another name] Tai Ji grass, Canis familiaris L. take that son, rattan Radix Achyranthis Bidentatae, short lobe Dianthus chinensis, Canis familiaris L. capital is climing, Radix Achyranthis, cramp grass, SONGJINTENG by force.[source] medical material Ji Yuan: for root or the herb of pinkwort Brachystemma calycina D. Don..[nature and flavor] are sweet；Bitter；Property is put down.[return through] liver；Spleen channel.[function cures mainly] blood circulation promoting and blood stasis dispelling；Treating stranguria let out turbid；Removing toxic substances and promoting subsidence of swelling.Main dysmenorrhea due to blood stasis；Amenorrhea；Vicarious menstruation；Lump in the abdomen lumps；Pyretic stranguria；Stranguria with blood；Nebulousurine；Leucorrhea；Arthralgia pain enters network；Passages through which vital energy circulates contracture；Traumatic injury；Carbuncle sore tumefacting virus；Tonsillitis；Diphtheria.[each discussion] " choosing of Yunnan Chinese herbal medicine ": eliminating dampness and promoting diuresis, relaxing muscles and tendons to promote blood circulation.Control traumatic injury, fracture, chronic lambago and skelalgia, rheumatic arthralgia, oedema due to nephritis, urinary tract infection.[extracts] " China's book on Chinese herbal medicine "

Herba Clematidis loureirianae: [another name] wild Caulis Akebiae, Caulis Clematidis Chrysocomae, ferrum foot Wheeling, RADIX ANEMONAE.[source] medical material Ji Yuan: for rattan or the root of ranunculaceae plant gold pig-iron line.[nature and flavor] sweet in the mouth；Light；Property is put down.[return through] returns liver；Kidney；Bladder warp.[function cures mainly] clearing away heat and promoting diuresis；Promoting blood circulation to restore menstrual flow；Expelling wind and removing dampness.Main dysuria；Edema；Damp-heat gonorrhoea；Rheumatic arthralgia；Traumatic injury；Inflammation on wind-fire；Eye red pain；Amenorrhea；Mange.[extracts] " China's book on Chinese herbal medicine "

Cortex Hibisci: [another name] flour water bird, silks and satins rattan, silver the back of the body rattan, in vain carry on the back silk fabric, white peony, silver notopodium, silks and satins leaf.[source] medical material Ji Yuan: for the stem and leaf of convolvulaceous plant Caulis et Folium Argyreia eacutae.[nature and flavor] are pungent；Micro-hardship；Cool.[function cures mainly] expelling wind and removing dampness；Preventing phlegm from forming and stopping coughing；Dissipating blood stasis stops blooding；Removing toxicity for eliminating carbuncles.Main air pain of dampness syndrome；Edema；Expand；Cough with asthma abundant expectoration；Leukorrhagia；Metrorrhagia；Hematmesis due to visceral injury；Traumatic injury amasss the stasis of blood；Acute mastitis；Furuncle；Rotten foot；Eczema.[extracts] " China's book on Chinese herbal medicine "

Flos micheliae Albae: [another name] Bai Mianhua, Bai Mulan, Michelia champaca, remote Flos Osmanthi Fragrantis.[source] medical material Ji Yuan: for the flower of Magnoliacea plant white orchid.[nature and flavor] are bitter；Pungent；Slightly warm in nature.[function cures mainly] removing dampness；Circulation of qi promoting；Cough-relieving.Main abdominal distention uncomfortable in chest；Heatstroke；Cough；Prostatitis；Leucorrhea.[each discussion] Guangzhou air force " conventional Chinese herbal medicine handbook ": activating QI and resolving turbid pathogen, cough-relieving.Control prostatitis, women leucorrhea, infantile bronchitis, asthenia chronic cough.[extracts] " China's book on Chinese herbal medicine "

Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii: [another name] Radix Zanthoxyli Spinifolii, Herba Chenopodii Hybridi, Radix Schisandrae Micranthae, peppery medicine.[source] medical material Ji Yuan: for Herb or the root of ranunculaceae plant five leaf Radix clematidis floridae.[nature and flavor] acrid in the mouth；Warm in nature.[function cures mainly] expelling wind and removing dampness；Promoting blood circulation and stopping pain.Main air temperature arthralgia pain；Numb limbs and tense tendons, cold of insufficiency type and stomachache；Stomachache is vomited and diarrhoea；Dysmenorrhes；Amenorrhea；Traumatic injury；Migraine；Neuralgia；Facial paralysis.[extracts] " China's book on Chinese herbal medicine "

Schisandra glaucescens Diels.: emaciation due to emotional upset, ash Fructus Schisandrae Chinensis in [another name] powder leaf.[source] medical material Ji Yuan: for rattan and the root of Schisandraceae Plant Kingsoft Fructus Schisandrae Chinensis.[nature and flavor] are sweet；Bitter；Slightly warm in nature.[function cures mainly] expelling wind and activating blood circulation；Dissipating blood stasis for subsidence of swelling.Main air pain of dampness syndrome；Impairment caused by overstrain takes off power；Goiter；Toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Radix seu Caulis Schisandrae Sinensis: [another name] Radix Morindae Officinalis, Herba Galii Teneri, Caulis et Folium piperis, MANSHANXIANG, fragrant Caulis seu Radix Schisandrae Henryi, blood stick with paste rattan, fragrant bar halberd, wild Fructus Schisandrae Chinensis.[source] medical material Ji Yuan: for ratan or the root of Schisandraceae Plant Cortex cynoglossi zeylanici radicis.[nature and flavor] are pungent；Warm in nature.[function cures mainly] expelling wind and activating blood circulation；Removing toxic substances and promoting subsidence of swelling；Hemostasis.Main rheumatic numbness；Bones and muscles pain；Traumatic injury；Menoxenia；Stomachache；Abdominal distention；Carbuncle sore tumefacting virus；Over-strained hemoptysis.[each discussion] 1, " vegetation is side just ": raw painstaking effort, removing blood stasis and activating blood flow, saturating joint, control traumatic injury blood swollen, extremity muscles and bones pathogenic wind toxic.2, " Chongqing medical herbs ": circulation of qi promoting, invigorates blood circulation.Control traumatic injury, over-strained hemoptysis, amenorrhea.3, " Shaanxi Chinese herbal medicine ": promoting blood flow to regulate menstruation, dissipating blood stasis for subsidence of swelling, regulating QI to relieve pain.Control menoxenia, leucorrhea, impairment caused by overstrain, traumatic injury, furuncle hernia, lung abscess.[extracts] " China's book on Chinese herbal medicine "

Herba Melasmatis arvensis: [another name] Arisaema balansae Engl. grass.[source] medical material Ji Yuan: for the herb of the black capsule of goatweed.[nature and flavor] mildly bitter flavor；Cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis；Promoting blood circulation to remove blood stasis.Main icterohepatitis；Tripe splenomegaly；Traumatic injury；Dysmenorrhea.[extracts] " China's book on Chinese herbal medicine "

Caulis Clematidis pseudopogonandrae: [source] medical material Ji Yuan: for the ratan of ranunculaceae plant vacation palpus stamen Radix clematidis floridae.[nature and flavor] bitter in the mouth；Cold in nature.[return through] GUIXIN；Small intestinal；Bladder warp.[function cures mainly] clearing away heat and promoting diuresis；Stimulating milk secretion.Main edema；Dysuria；Damp-heat gonorrhoea；Chronic dysentery；Aphtha of the mouth and tongue；Galactostasis.[extracts] " China's book on Chinese herbal medicine "

When the dosage form of described Chinese medicine preparation is tablet, it comprises the following steps:

Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.

Embodiment 1: oral solutions prepared by the present invention

Take Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 160g, Fructus solani xanthocarpi 280g, Catalpa ovata G. Don wood 210g, Radix polygalae arillatae 350g, Radix et rhizoma smilacinae japonicae 360g, Pericarpium Musae Sapienti 250g, Radix Rauvolfiae 270g, Radix Ervatamiae Hainanensis 340g, Herba Cardui Crispi 170g, Radix seu Ramulus Diospyroris rhombifoliae 350g, Cortex Ulmi virgatae 220g, Herba Lycopodii Obscuri 190g, Radix Cucubali 220g, Herba Clematidis loureirianae 290g, Cortex Hibisci 370g, Flos micheliae Albae 180g, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 210g, Schisandra glaucescens Diels. 150g, Radix seu Caulis Schisandrae Sinensis 170g, Herba Melasmatis arvensis 280g and Caulis Clematidis pseudopogonandrae 210g.

Its preparation method comprises the following steps:

The first step, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Fructus solani xanthocarpi, Catalpa ovata G. Don wood, Radix polygalae arillatae, Radix et rhizoma smilacinae japonicae, Pericarpium Musae Sapienti, Radix Rauvolfiae, Radix Ervatamiae Hainanensis, Herba Cardui Crispi, Radix seu Ramulus Diospyroris rhombifoliae, Cortex Ulmi virgatae and Herba Lycopodii Obscuri are mixed in proportion, with the methanol that determining alcohol is 80% as solvent, adopt percolation with the speed slowly percolation of 1ml per minute, collecting percolate, concentrating under reduced pressure also dries, it is thus achieved that dry cream, being ground into powder, the quality of affiliated methanol is 6 times of first step mixture quality；

Second step, is mixed in proportion surplus stock medical material, is ground into powder；Add the distilled water relative to the powder quality 6 times obtained, decoct 4 hours, filter, it is thus achieved that the first filtrate；Filtering residue is added the distilled water relative to its quality 3 times, decocts 3 hours, filter, it is thus achieved that the second filtrate；Merging the first filtrate and the second filtrate, concentrate away the water of 2/3 volume, adding determining alcohol is the ethanol of 90%, makes determining alcohol reach 75%, stands 24 hours, filters, concentrating under reduced pressure, dry, it is thus achieved that dry cream, is ground into powder；

3rd step, the powder mixing that the first step and second step are obtained, add the distilled water relative to powder quality 4.2 times amount, the sucrose of 0.35 times, the sodium benzoate of 0.02 times, stirring, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Embodiment 2: tablet prepared by the present invention

Take Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 190g, Fructus solani xanthocarpi 270g, Catalpa ovata G. Don wood 230g, Radix polygalae arillatae 320g, Radix et rhizoma smilacinae japonicae 380g, Pericarpium Musae Sapienti 210g, Radix Rauvolfiae 250g, Radix Ervatamiae Hainanensis 320g, Herba Cardui Crispi 190g, Radix seu Ramulus Diospyroris rhombifoliae 320g, Cortex Ulmi virgatae 250g, Herba Lycopodii Obscuri 160g, Radix Cucubali 250g, Herba Clematidis loureirianae 270g, Cortex Hibisci 400g, Flos micheliae Albae 150g, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 250g, Schisandra glaucescens Diels. 120g, Radix seu Caulis Schisandrae Sinensis 190g, Herba Melasmatis arvensis 270g and Caulis Clematidis pseudopogonandrae 240g.

Its preparation method comprises the following steps:

The first step, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Fructus solani xanthocarpi, Catalpa ovata G. Don wood, Radix polygalae arillatae, Radix et rhizoma smilacinae japonicae, Pericarpium Musae Sapienti, Radix Rauvolfiae, Radix Ervatamiae Hainanensis, Herba Cardui Crispi and Radix seu Ramulus Diospyroris rhombifoliae are mixed in proportion, add relative to the alcohol reflux that mixture 5 times amount determining alcohol is 65% 2 times, each 3 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, standby；

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times amount water, boils 4 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.28；

3rd step, the mastic mixing first step, second step obtained, 65 DEG C of reduced vacuum dry, and get dry extract powder；

4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；

5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 2.8: 0.22.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20～32g, carries out acute toxicity test.Mice is randomly divided into two groups, i.e. matched group and administration group, fasting 12 hours before experiment, the extract oral liquor prepared by embodiments of the invention 1 is dissolved in water, (concentration is 8.56g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.8 crude drugs/kg), and matched group gives normal saline, within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Oral solutions LD50 > 42.8 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 85.6 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention be 8.28g crude drug/day/people, adult body weight in 60KG, average dosage is 0.138g crude drug/kg/ day.By weighing machine: 620 times that the dosis tolerata of the Chinese medicine of mice (average weight with 26g) the oral administration gavage present invention is quantity.Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 oral solutions of the present invention to three groups of mices (often group 20) by 14.26,26.38 and 44.19g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 3 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, Organs of Mice is all without substantially changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.

Clinical data:

Case selection: all 64 selected example cases derive from this Out-patient Department and the anemic cardiopathy patient being in hospital, and are randomly divided into two groups, treatment group 32 example, male 21 examples, female 11 example；29～70 years old age；Cardiac function: II grade of 17 example, III grade of 11 example, IV grade of 4 example.Matched group 32 example, male 22 examples, female 10 example；31～71 years old age；Cardiac function: II grade of 17 example, III grade of 12 example, IV grade of 3 example.Treatment group compares no significant difference with matched group in each side such as sex, age, cardiac functional grading and clinical manifestations, has comparability.

Diagnostic criteria: 1, have anemia (Hb≤70g/L) and Anemia (as tired, weak, uncomfortable in chest, breathe hard and cardiopalmus etc.).2, meet following at least one: 1. imaging examination prove cardiac dilatation；2. electrocardiogram is that ischemic ST-T changes or the change of infarction sample；3. bring out or increase the weight of angina pectoris attacks；4. there are cardiac insufficiency or congestive heart failure performance.

Cardiac functional grading (NYHA) standard: I grade: patient has a heart disease but activity is unrestricted, general activity does not cause tired, cardiopalmus, dyspnea or angina pectoris at ordinary times.II grade: the physical exertion of cardiac is subject to slight restriction, no conscious sympton during rest, but may occur in which tired, cardiopalmus, dyspnea or angina pectoris under general activity at ordinary times.III grade: cardiac's physical exertion substantially limits, namely cause above-mentioned symptom less than general activity at ordinary times.IV grade: cardiac can not be engaged in any physical exertion.The symptom of heart failure, physical exertion postemphasis also occur under resting state.

Therapeutic Method:

Matched group: give regular western medicine Comprehensive Treatment, including giving oxygen uptake, blood transfusion (making hemoglobin (Hb) maintain 70～80g/L), diuresis, hemostasis etc..Cure the Primary Disease, such as iron deficiency anemia person, gives ferrous sulfate；Because of folic acid, vitamin B₁₂Lack caused megaloblastic anemia person, give appropriate folic acid, vitamin B₁₂Treatment；Other diseases, gives doctor trained in Western medicine routine immunotherapy targeted autoantibody.Within 1 week, it is 1 course for the treatment of, treats 2 courses for the treatment of.

Treatment group: on matched group western medicine routine treatment basis, simultaneously oral Chinese medicine embodiment 1 oral solutions of the present invention, each 20ml, every day 3 times.Within 1 week, it is 1 course for the treatment of, treats 2 courses for the treatment of.

Curative effect judging standard: effective: clinical symptoms and sign disappear or be obviously improved, every inspection is recovered normal or is obviously improved, and heart function recovery is normal, correct to 1 grade or progressive two-stage.Effective: clinical symptoms, sign and every inspection make moderate progress, cardiac function progress one-level.Invalid: clinical symptoms, sign and every inspection do not improve or increase the weight of, cardiac function is without improving or increasing the weight of.

Therapeutic outcome: two groups treat 2 weeks respectively after, statistical result is referring to table 1.

Clinical efficacy comparison (unit: example) after treating respectively 2 weeks organized by 1 liang of table

Group	Number of cases	Effective	Effectively	Invalid	Total effective rate
						Treatment group	32	26	5	1	31 (96.88%)
Matched group	32	20	8	4	28 (87.5%)

As it can be seen from table 1 treatment group adopts the Chinese medicine of the present invention, coordinate western medical treatment anemic cardiopathy, relative to matched group, on therapeutic effect, have and be markedly improved.

Untoward reaction: hepatic and renal function injure or other obvious adverse reaction all do not occur during treating in both patients.

Concrete case: patient in certain, man, 64 years old, have iron deficiency anemia medical history, patient without tachypnea after obvious inducement appearance activity fatigue, uncomfortable in chest, can be alleviated after tranquillization before 6 months.Not giving diagnosis and treatment, symptom increases the weight of gradually.Over nearly 1 month, climbing 2 floor ladders and namely feel tachypnea, uncomfortable in chest, cardiopalmus, squeeze sample pain, radiate to back after fatigue after may occur in which breastbone, after tranquillization, pain can be alleviated, and comes to go to a doctor.Through auxiliary examinations such as chest x-ray film, electrocardiogram, routine blood tests, it is diagnosed as anemic cardiopathy, Ⅲcardiac function.On the bases such as western medicine routine treatment (including oxygen uptake, blood transfusion, diuresis, hemostasis and ferrous sulfate etc.), oral Chinese medicine embodiment 1 oral solutions of the present invention, each 20ml, every day 3 times simultaneously.Treating 2 weeks, clinical symptoms and sign disappear, and every inspection recovers normal substantially, and heart function recovery is normal, effective, follow up a case by regular visits to 3 months without recurrence.

All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement or the new method that limit other forms.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above.But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.

Claims

1. the Chinese medicine preparation treating anemic cardiopathy, it is characterized in that, described Chinese medicine preparation includes following raw medicinal material: Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae), Fructus solani xanthocarpi, Catalpa ovata G. Don wood, Radix polygalae arillatae, Radix et rhizoma smilacinae japonicae, Pericarpium Musae Sapienti, Radix Rauvolfiae, Radix Ervatamiae Hainanensis, Herba Cardui Crispi, Radix seu Ramulus Diospyroris rhombifoliae, Cortex Ulmi virgatae, Herba Lycopodii Obscuri, Radix Cucubali, Herba Clematidis loureirianae, Cortex Hibisci, Flos micheliae Albae, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii, Schisandra glaucescens Diels., Radix seu Caulis Schisandrae Sinensis, Herba Melasmatis arvensis and Caulis Clematidis pseudopogonandrae.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15～25 parts, Fructus solani xanthocarpi 20～30 parts, 15～30 parts of Catalpa ovata G. Don wood, Radix polygalae arillatae 25～35 parts, Radix et rhizoma smilacinae japonicae 30～40 parts, Pericarpium Musae Sapienti 15～25 parts, Radix Rauvolfiae 20～35 parts, Radix Ervatamiae Hainanensis 25～40 parts, Herba Cardui Crispi 10～20 parts, Radix seu Ramulus Diospyroris rhombifoliae 25～35 parts, Cortex Ulmi virgatae 20～30 parts, Herba Lycopodii Obscuri 15～25 parts, Radix Cucubali 15～30 parts, Herba Clematidis loureirianae 20～35 parts, Cortex Hibisci 30～40 parts, Flos micheliae Albae 15～25 parts, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 20～30 parts, Schisandra glaucescens Diels. 5～15 parts, Radix seu Caulis Schisandrae Sinensis 10～20 parts, Herba Melasmatis arvensis 25～35 parts and Caulis Clematidis pseudopogonandrae 20～30 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 15～20 parts, Fructus solani xanthocarpi 25～30 parts, 20～25 parts of Catalpa ovata G. Don wood, Radix polygalae arillatae 30～35 parts, Radix et rhizoma smilacinae japonicae 35～40 parts, Pericarpium Musae Sapienti 20～25 parts, Radix Rauvolfiae 25～30 parts, Radix Ervatamiae Hainanensis 30～35 parts, Herba Cardui Crispi 15～20 parts, Radix seu Ramulus Diospyroris rhombifoliae 30～35 parts, Cortex Ulmi virgatae 20～25 parts, Herba Lycopodii Obscuri 15～20 parts, Radix Cucubali 20～25 parts, Herba Clematidis loureirianae 25～30 parts, Cortex Hibisci 35～40 parts, Flos micheliae Albae 15～20 parts, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 20～25 parts, Schisandra glaucescens Diels. 10～15 parts, Radix seu Caulis Schisandrae Sinensis 15～20 parts, Herba Melasmatis arvensis 25～30 parts and Caulis Clematidis pseudopogonandrae 20～25 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: 21 parts of Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 16 parts, Fructus solani xanthocarpi 28 parts, Catalpa ovata G. Don wood, Radix polygalae arillatae 35 parts, Radix et rhizoma smilacinae japonicae 36 parts, Pericarpium Musae Sapienti 25 parts, Radix Rauvolfiae 27 parts, Radix Ervatamiae Hainanensis 34 parts, Herba Cardui Crispi 17 parts, Radix seu Ramulus Diospyroris rhombifoliae 35 parts, Cortex Ulmi virgatae 22 parts, Herba Lycopodii Obscuri 19 parts, Radix Cucubali 22 parts, Herba Clematidis loureirianae 29 parts, Cortex Hibisci 37 parts, Flos micheliae Albae 18 parts, Folium Salicis Babylonicae Radix Zanthoxyli Spinifolii 21 parts, Schisandra glaucescens Diels. 15 parts, Radix seu Caulis Schisandrae Sinensis 17 parts, Herba Melasmatis arvensis 28 parts and Caulis Clematidis pseudopogonandrae 21 parts.

5. the Chinese medicine preparation as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is oral solutions, and its preparation method comprises the following steps:

6. the Chinese medicine preparation as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:

7. the preparation method of the Chinese medicine preparation described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is oral solutions, and its preparation method comprises the following steps:

8. the preparation method of the Chinese medicine preparation described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps: