CN103721153A - Traditional Chinese medicinal composition for resisting swine virus infection - Google Patents
Traditional Chinese medicinal composition for resisting swine virus infection Download PDFInfo
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- CN103721153A CN103721153A CN201310715259.XA CN201310715259A CN103721153A CN 103721153 A CN103721153 A CN 103721153A CN 201310715259 A CN201310715259 A CN 201310715259A CN 103721153 A CN103721153 A CN 103721153A
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Abstract
The invention discloses a traditional Chinese medicinal composition for resisting swine virus infection, aiming at solving a technical problem of providing a new medicine which is simple in formula, convenient and simple in preparation process, low in toxic and side effect, convenient for administration, easy to prepare, low in cost, and free from influence on eating taste to result in swine rejection. The medicine disclosed by the invention, which can improve swine immunity, benefit qi and blood, warm spleen and stomach for dispelling cold, clear away heat and resist virus, is prepared from the following raw materials in parts by weight: 50-80 parts of fish meal, 10-20 parts of medicated leaven, 10-20 parts of Chinese lobelia, 10-20 parts of bitter gourd, 10-20 parts of polygonum multiflorum, 10-20 parts of dwarf galangal rhizome, 10-20 parts of amur ampelopsis root, 10-20 parts of herba verbenae, 20-30 parts of broomcorn millet fruit, 20-30 parts of jobstears leaf, 1-10 parts of yam, 1-10 parts of asparagus, 1-10 parts of mulberry and 10-20 parts of brown sugar.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly the Chinese medicine composition of a boar viral infection resisting.
Background technology
It is a major industry of China's animal husbandry development that ecological pig produces, a main pillar of Ye Shi China livestock products foreign exchange earning, be aspect increasing national income and uplifting the people's living standard, accelerate Development of farming and animal husbandry, adjust the important goal of the aspects such as agriculture industrialization structure.
According to strict ecologic breeding, pig is not cooked epidemic prevention and processes, feed request non agricultural chemical residuum, heavy metal free, without other additives outside inorganic salts, live pig Excreta is done harmless treatment, such as biogas fermentation etc., make the fertilizer of crops, shipment is butchered and is all accomplished basic humanity again, and Carnis Sus domestica is out without pathological changes.
Method for breeding: ecological pig will be raised with ecological method, it is exactly the relation of effectively utilizing various poultry and aquaculture, agricultural planting, form an eucyclic Food chain, turn waste into wealth, comprehensive exploitation, with minimum cost, create maximum benefit, finally reduce the destruction to ecological environment.Main Patterns has:
(1) pig fish comprehensive feeding, pig manure is fed fish;
(2) chicken pig fish comprehensive feeding, chicken manure feeds pigs, and pig manure is fed fish;
(3) pig natural pond dish pattern, pig manure is done biogas, and natural pond slag, natural pond liquid plant vegetables;
(4) pig natural pond fruit pattern pig manure is done biogas, natural pond slag, natural pond liquid planting fruit-trees etc.
Pig virus infects and has produced communicable diseases:
1.1 blue-ear diseases (PRRS)
Blue-ear disease has become the main epidemic disease of harm pig industry, in swinery, extensively exists, and its infection rate reaches 61.5%～85%.Cause kind of a pig breeding dysfunction, cause miscarriage, produce stillborn fetus and weak son.Be swinery generation innominate high fever disease and the syndromic main pathogen of respiratory tract disease, cause the large quantities of Mortalities of pig.
atypia swine fever (HC)
Swine fever is one of epidemic disease that harm China pig industry is the most serious, has generation throughout the year.Every year because swine fever causes dead pig, account for 30% of the pig sum of all dying of illness, add miscarriage, produce stillborn fetus, eliminate boar etc., annual direct economic loss is billions of yuans more than.
circovurus type 2 infects (PCV-2)
Circovurus type 2 infects commonplace existence in China swinery, and what kind pig farm positive rate was low is 50%, and high reaches 82%.Very large to the harm of first farrowing sow, can cause more than 70% first farrowing sow to miscarry, produce stillborn fetus.
porcine pseudorabies (PR)
Current, characteristics of incidence is by typical case, to atypia, to be developed clinically, transfers to and take inapparent infection as main, and morbidity does not show seasonality, but occurs in regular hour and space.Once as there is typical clinical symptoms, majority of cases shows as and other cause of diseases, as blue-ear disease poison, swine fever virus, porcine circovirus or parvovirus mixed infection, and secondary streptococcus, escherichia coli and pasteurellosis bacillus etc., present the syndrome of many pathogen infections.
swine flue (SI)
Primary disease all can occur throughout the year, but majority of cases betides the early spring of climate variability. Qiu Chuhe winter.Rapid onset, propagates rapidly, in 2～3 days, can involve full group.Sickness rate is high, can reach 100%, and mortality rate is low, is generally no more than 4%.
pig hyperpyrexia syndrome
Primary disease is a kind of infectious disease by many pathogenic infections.Propagate soon, be endemicity popular, sickness rate is up to more than 50%, and indivedual serious swinerys reach 70% left and right, and mortality rate is more than 40%～50%.The four seasons all can occur, but mainly betide summer and autumn.
the sick syndrome (PRDC) of porcine respiratory
Primary disease is the infectious disease being caused by multiple-factor.Protopathy was blue-ear disease virus, mycoplasma pneumoniae, influenza virus, Pseudorabies virus, circovurus type 2, PRCV (Porcine Respiratory Coronavirus) etc. originally.
Summary of the invention
Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, with low cost, and abnormal smells from the patient does not affect pig eating mouth feel and causes the new drug that pig is resisted.Medicine of the present invention improves pig immunity, benefiting vital QI and blood, warming spleen and stomach for dispelling cold, heat clearing away, antiviral.The present invention adopts the Chinese crude drug of different properties, has carried out science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, and preparation is simple, the focus of going directly, and healing time is short, after curing, is difficult for recurrence.
The Chinese medicine composition of one boar viral infection resisting is to be made by following weight portion raw material:
Fish flour 50-80 part, Massa Medicata Fermentata 10-20 part, Herba Lobeliae Chinensis 10-20 part, Fructus Momordicae charantiae 10-20 part, Radix Polygoni Multiflori 10-20 part, Rhizoma alpiniae pumilae 10-20 part, Radix ampelopsis brevipedunculatae 10-20 part, Herba Verbenae 10-20 part, Panicum miliaceum L. 20-30 part, Folium Coicis 20-30 part, Rhizoma Dioscoreae 1-10 part, Germinatus Phragmitis 1-10 part, Fructus Mori 1-10 part, brown sugar 10-20 part.
The Chinese medicine composition of one boar viral infection resisting is to be made by following weight portion raw material:
Fish flour 55-75 part, Massa Medicata Fermentata 12-18 part, Herba Lobeliae Chinensis 12-18 part, Fructus Momordicae charantiae 12-18 part, Radix Polygoni Multiflori 12-18 part, Rhizoma alpiniae pumilae 12-18 part, Radix ampelopsis brevipedunculatae 12-18 part, Herba Verbenae 12-18 part, Panicum miliaceum L. 22-28 part, Folium Coicis 22-28 part, Rhizoma Dioscoreae 2-8 part, Germinatus Phragmitis 2-8 part, Fructus Mori 2-8 part, brown sugar 12-18 part.
The Chinese medicine composition of one boar viral infection resisting is to be made by following weight portion raw material:
60 parts of fish flour, 15 parts of Massa Medicata Fermentata, 15 parts of Herba Lobeliae Chinensis, 15 parts, Fructus Momordicae charantiae, 15 parts of Radix Polygoni Multiflori, 15 parts of Rhizoma alpiniae pumilaes, 15 parts of Radix ampelopsis brevipedunculataes, 15 parts of Herba Verbenae, 25 parts of Panicum miliaceum L., 25 parts of Folium Coicis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Germinatus Phragmitiss, 5 parts, Fructus Mori, 15 parts, brown sugar.
The Chinese medicine composition of one boar viral infection resisting, the dosage form of pharmaceutical preparation is honey refining pill, its preparation method comprises:
A, first Fructus Mori, Germinatus Phragmitis, Rhizoma Dioscoreae, Fructus Momordicae charantiae ovendry power are broken into powder;
B, the surplus stock medicine of getting except brown sugar and fish flour are again put into soak with ethanol, and heat is extracted 2 times, become extractum shape, are component 1;
C, medicinal residues extracting in water 1 time, thickening filtration is extractum shape, is component 2;
D, above-mentioned two kinds of extractum are condensed into pasty state, add powder that a step obtains and fish flour, brown sugar, add Mel and be twisted into pill.
In described step b, get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-10 doubly to measure, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid,, 80-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, extracts active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, and stand for standby use, becomes component 1; In described step c, medicinal residues add 5-10 times of water gaging and soak 1-2 hour, within 1-1.5 hour, extract 1 time, as component 2.
The Chinese medicine composition of one boar viral infection resisting, pharmaceutical dosage form is powder agent, its preparation process comprises:
A, all crude drug except fish flour and brown sugar are put into ethanol heating and refluxing extraction;
B, again by medicinal residues water heating and refluxing extraction;
C, above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain medicated powder and mix homogeneously with fish flour and brown sugar.
In described step a, raw medicinal material is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged to filtering and standing; In described step b, the medicinal residues that refined are put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes～1 hour, merges 3 extracting solution filtering and standing.
In described step c, above-mentioned two kinds of filtrates are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.06; The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain raw material medicated powder and mix homogeneously with fish flour and brown sugar.
the present invention relates to raw material of Chinese medicine pharmacology and the property of medicine as follows:
Herba Coriandri:
[another name]: Herba Coriandri, Yuan Mu, coriander, Caulis et Folium Brassicae campestris, former Sui, garden Sui, coriander, Coriander, Herba Coriandri, tabernaemontanus bulrush Sui, Yan Sui Cai, Yan Pueraria lobota grass, Caulis et folium pavettae hongkongensis, salt cooked food, salt shine, silver whiskers Herba Coriandri, cry the earliest " Herba Coriandri ", < < Jiayou Bencao > > begins to be loaded in.
[property of medicine] is pungent, temperature.Attach to the lung and stomach meridians.
[effect] Herba Coriandri is pungent, warm, returns lung, spleen channel; There is diaphoresis rash, removing stagnancy of indigested food and making QI downward, be amusing and in effect; Cure mainly the measles initial stage, appear the diseases such as not smooth and food is stagnant, appetite is not opened, proctoptosis.
1. measles: 3 strains of Herba Coriandri Nelumbo nucifera Gaertn, 3 of Corm Eleocharitiss, 3 grams of Laccas, add the more than half bowl of water, decoct filtered juice after 15 minutes, and minute 2 clothes, every 4 hours clothes once, taking during eruption, can prevent complication; Or 500 grams, Herba Coriandri, after water is boiled, Herba Coriandri is boiled to 1～2 and boils, then water is poured in basin, first with steam, smoke, after wash brothers with water, can control that measles should can not go out or rash goes out not saturating.
2. cold syndrome of the stomach is bitterly: 1000 grams, Herba Coriandri leaf, and 500 milliliters of wines, immerse Herba Coriandri, and after 3 days, defoliation is drunk, and during pain, takes 15 milliliters.
3. hemorrhoid are swollen aches and proctoptosis: Herba Coriandri is boiled soup, with this soup, smokes and washes affected part.
4. dyspepsia, inappetence ceriander seed (fruit) are 6 grams, each 9 grams of Pericarpium Citri Reticulatae, six songs, and 3, Rhizoma Zingiberis Recens, is decocted in water for oral dose.
5. hypertension: with fresh 10 grams, add 10 grams of Radix Puerariaes and be decocted in water for oral dose, each 1 time sooner or later, each serving 50 milliliters, taking 10 days is 1 course for the treatment of, and treatment hypertension is had to auxiliary curative effect.
6. oh make a mistake: 6 grams, Herba Ocimi (Herba Ocimi Pilosi) leaf (fresh leaf doubles), 3, Rhizoma Zingiberis Recens, boiled water steeps or decocts one and boils, while hot clothes.
7. chest and diaphragm is full vexed: ceriander seed is ground into powder, and each 3 grams, boiled water is swallowed.
8. vomiting: it is spoonful that the fresh grass of regurgitation is smash juice in right amount, and two spoons of Caulis Sacchari sinensis juices, add decoction being taken warmly, 2 times on the one.
9. the raw nebula of cornea: seed 1-2 grain, clean, include in eye adjoins, close order a moment later, seed bulking, adhesion order is searched.
10. Common Cold: 30 grams, Herba Coriandri, 15 grams of maltoses, with half bowl of rice water, sugar steams and dissolves rear clothes.
Massa Medicata Fermentata:
[nature and flavor] hardship, temperature.The property of medicine is examined: micro-bitter fragrant sweet.Detailed outline is picked up any lost article from the road: sweet light, and delicate fragrance.
[function with cure mainly] induce sweat and in.For cold and heat headache, in dyspepsia resistance, vomiting distension.
[character] this product is the block thing of filemot rectangle, and outer surface is coarse, and yellowish-brown has white mould, and section is loose, yellowish-brown; Gas delicate fragrance, taste is micro-.
Germinatus Phragmitis:
[pharmacology value] 1, contribute to stabilize blood pressure blood fat reducing; 2, contribute to suppress cardiovascular disease; 3, contribute to prevention and anticancer; 4, contribute to prevent and treat senile constipation, diuresis is recovered from fatigue; 5, contribute to suppress and resist viral bacterium; 6, contribute to health invigorating allaying tiredness.
[nutritive value] 1, homovitamin, high-cellulose, high protein 2, low sugar, low fat 3, a great number of elements that contains multiple needed by human and trace element
[health-care effect] 1, cancer-resisting effect, can suppress topoisomerase enzymatic activity, directly kills cancerous cell, and destruction of cancer cells telomerase makes the cancerous cell can not multiple fission and wither it, activates antioncogene adjustment signal, transfer cell growth normalization.2, the therapeutical effect to cardiovascular disease, Germinatus Phragmitis can suppress hypertension, prevents sclerosis of blood vessels, reduces blood fat and cholesterol.3, the impact on human immune system, Germinatus Phragmitis can reduce circulating immune complex CIC content, can produce thymosin, promotes the generation of T cell, thereby improves immunologic function, regulates immunologic mechanism.4, the effect aspect defying age can reduce the lipid peroxide of human organ, the content of LOP, thereby the activity slow down aging of raising superoxide dismutase SOD.
Herba Lobeliae Chinensis:
[nature and flavor] are pungent, light, cool.
[return through] returns liver, stomach, kidney, small intestine meridian.
[drug effect] relieve internal heat anticancer, diuretic heat clearing away, treat skin ulcer detumescence.
Fructus Mori:
[nature and flavor] are sweet, are slightly cold; GUIXIN, liver, kidney channel.
[function cures mainly] controls hepatic and renal YIN deficiency, and send and take off, constipation, order is dark, tinnitus, former infections, articular instability.It is improved skin (comprising scalp) blood supply, nutrition skin, makes the effects such as the delicate and black hair of skin, and can slow down aging.Fructus Mori is be healthy and strong U.S. face, antidotal good fruit and good medicine of middle-aged and elderly people.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fructus Mori has immunologic enhancement.Fructus Mori has effect of gain to spleen, and to hemolytic, reaction has potentiation, can prevent human body artery sclerosis, skeleton arthrosclerosis, enhances metabolism; Fructus Mori can promote the growth of erythrocyte, prevents leukopenia, and the diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenia are had to auxiliary curative effect.Fructus Mori has the effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.The traditional Chinese medical science thinks, Fructus Mori is sweet in flavor and cold in property, has the liver and the kidney tonifying, an effect such as the intestine moistening of promoting the production of body fluid, black hair improving eyesight.
Fructus Momordicae charantiae:
[meridian distribution of property and flavor] hardship, cold.Return spleen, stomach, the heart, Liver Channel.
[effect] heat clearing away heart-fire of dispelling, removing toxic substances, improving eyesight, QI invigorating benefit essence, quenches the thirst and relieves summer heat, and controls carbuncle.
Radix Polygoni Multiflori:
[meridian distribution of property and flavor] is bitter, sweet, puckery, and temperature is returned liver, the heart, kidney channel.
[function cures mainly] removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia, has therapeutical effect to diseases such as neurasthenia, poliosis, alopecia, anemias, therefore, and delaying sanility, building body, health care heart.
Rhizoma Dioscoreae:
[nature and flavor] sweet in the mouth, property are put down, and enter lung, spleen, kidney channel;
[function cures mainly] have strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, grow that will is calmed the nerves, the effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red disease such as swollen, fat of the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.
Folium Coicis:
[collection] summer, autumn take.
[chemical composition] leaf is containing alkaloid.
[effect of cure mainly-Folium Coicis of function]
1. < < Bencao Tujing > >: for drinking perfume (or spice), beneficial hollow diaphragm.
2. the trifling record of < < > >: the summer-heat moon is decocted drink, warming the stomach, replenishing QI and blood.
The effect with warming spleen and stomach for dispelling cold, benefiting vital QI and blood, cures mainly cold syndrome of the stomach pain, the symptom of deficient qi and blood.
Panicum miliaceum L.:
Nature and flavor: sweet, flat.
1. < < does not record > >: sweet in the mouth is nontoxic.
2. < < a thousand pieces of gold dietetic therapy > >: sweet in the mouth is flat, nontoxic.
3. < < Bencao Shiyi > >: property is cold.
Gui Jing: enter spleen, stomach warp.
1. the < < book on Chinese herbal medicine > > that looks for the truth: enter spleen.
2. < < book on Chinese herbal medicine brief points > >; Enter that brothers are lunar, Yangming Channel.
The effect of cure mainly-Panicum miliaceum L. of function: and middle QI invigorating, removing heat from blood expelling summer-heat.
1. < < does not record > >: main QI invigorating, tonifying for the deficiency.
2. < < a thousand pieces of gold dietetic therapy > >: QI invigorating regulating the spleen and stomach, tonify deficiency stomach function regulating, should spleen.
3. < < Japan hanako materia medica > >: control heat, press borax poison, can separate a bitter a kind of edible gourd malicious.
4. < < detailed outline > >: removing heat from blood expelling summer-heat.
Usage and consumption: for oral administration: to cook or grind into powder.
Compatibility and incompatibility of drugs: < < Japan hanako materia medica > >: the polyphagia gas that feels cold.Can not be with river Radix Aconiti Lateralis Preparata with food.
Rhizoma alpiniae pumilae:
[nature,taste and action] is pungent, temperature.Expelling wind and removing dampness, vital energy regualting and blood circulation-promoting, removing toxic substances, pain relieving.
[function cures mainly] relieving cough and asthma, dispersing cold for relieving pain, except rheumatism, separates sore.For wind and cold cough with asthma, peratodynia, Fengshi Guanjie pain, falls and damages blood stasis stagnation, menoxenia, innominate toxic swelling.
Herba Verbenae:
Meridian distribution of property and flavor: hardship, cool.Return liver, spleen channel.
Venbenalin is excited in a small amount to SNE, suppresses in a large number; To mammal, can promote galactopoiesis.Heat and toxic materials clearing away medicine; Promoting blood circulation to restore menstrual flow medicine; Edema-alleviating diuretic; Preventing the attack (or recurrence) of malaria medicine; Promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.For lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria.
Radix ampelopsis brevipedunculatae:
Nature and flavor:
1. < < Quanzhou book on Chinese herbal medicine > >: sweet, flat, nontoxic.
2. < < Jiangxi medical herbs > >: property is flat, sweet in the mouth acid.
[function cures mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, the broken knot of dissipating blood stasis.
Control lung abscess, acute appendicitis, scrofula, rheumatalgia, carbuncle pyogenic infections from tumour or sore, traumatic injury, scalds.
1. < < Jiangxi medical herbs > >: relaxing muscles and tendons to promote blood circulation, subduing swelling and detoxicating.
2. < < Zhejiang conventional medical herbs > > among the people: removing blood stasis and activating blood flow, anti-inflammation, hemostasis.
3. Chinese herbal medicine handbook > > is commonly used in < < northeast: heat-clearing and toxic substances removing, granulation promoting pain relieving, hemostasis.
Brown sugar:
Nature and flavor: sweet, gentle, nontoxic.
Gui Jing: enter liver, spleen.Effect: profit cardiopulmonary, and in help spleen, slow irritability, alcoholic intoxication, enriches blood, removing blood stasis with potent drugs.
Cure mainly: trusted subordinate's flatulence of heat type, xerostomia wish drink, swelling and sore throat, cough due to lung-heat, cardiopulmonary and intestine and small intestine heat, alcoholism.
From the angle of the traditional Chinese medical science, brown sugar is warm in nature, sweet in the mouth, enter spleen, have vigorate qi and replenish the blood, spleen invigorating warming the stomach, slow in the effect of pain relieving, activating blood circulation to dissipate blood stasis.And to bring into play these effects of brown sugar, and in eating method, be also worthy of careful study very much: brown sugar poached egg, can make the nutrition complement of egg and brown sugar, allow old people have rosy cheeks, spiritedness; With brown sugar bubble dried Arillus Longan, take, to improving sleep, have positive role; Brown sugar bubble Radix Ginseng, has conditioning breath, improves hypotensive effect.
The specific embodiment
embodiment 1 formula:
Fish flour 50mg, Massa Medicata Fermentata 10mg, Herba Lobeliae Chinensis 10mg, Fructus Momordicae charantiae 10mg, Radix Polygoni Multiflori 10mg, Rhizoma alpiniae pumilae 10mg, Radix ampelopsis brevipedunculatae 10mg, Herba Verbenae 10mg, Panicum miliaceum L. 20mg, Folium Coicis 20mg, Rhizoma Dioscoreae 1mg, Germinatus Phragmitis 1mg, Fructus Mori 1mg, brown sugar 10mg.
The Chinese medicine composition of one boar viral infection resisting, the dosage form of pharmaceutical preparation is honey refining pill, its preparation method comprises:
A, first Fructus Mori, Germinatus Phragmitis, Rhizoma Dioscoreae, Fructus Momordicae charantiae ovendry power are broken into powder;
B, the surplus stock medicine of getting except brown sugar and fish flour are again put into soak with ethanol, and heat is extracted 2 times, become extractum shape, are component 1;
C, medicinal residues extracting in water 1 time, thickening filtration is extractum shape, is component 2;
D, above-mentioned two kinds of extractum are condensed into pasty state, add powder that a step obtains and fish flour, brown sugar, add Mel and be twisted into pill.
In described step b, get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-10 doubly to measure, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid,, 80-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, extracts active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, and stand for standby use, becomes component 1; In described step c, medicinal residues add 5-10 times of water gaging and soak 1-2 hour, within 1-1.5 hour, extract 1 time, as component 2.
Every 10kg body weight is taken 10-20g orally, is used in conjunction 5-7 days while having disease, and during without disease, medication in a week is maximum twice.
By appropriate warm water, soak in 1/3 or 1/4 water that medicinal liquid after 20 minutes is blended into whole day amount of drinking water and concentrate and drink, medicinal residues spice, effect is better, every day 2 times.
Embodiment 2, formula:
Fish flour 55mg, Massa Medicata Fermentata 12mg, Herba Lobeliae Chinensis 12mg, Fructus Momordicae charantiae 12mg, Radix Polygoni Multiflori 12mg, Rhizoma alpiniae pumilae 12mg, Radix ampelopsis brevipedunculatae 12mg, Herba Verbenae 12mg, Panicum miliaceum L. 22mg, Folium Coicis 22mg, Rhizoma Dioscoreae 2mg, Germinatus Phragmitis 2mg, Fructus Mori 2mg, brown sugar 12mg.
Preparation method is identical with embodiment 1 with usage and dosage.
Embodiment 3 formulas:
Fish flour 60mg, Massa Medicata Fermentata 15mg, Herba Lobeliae Chinensis 15mg, Fructus Momordicae charantiae 15mg, Radix Polygoni Multiflori 15mg, Rhizoma alpiniae pumilae 15mg, Radix ampelopsis brevipedunculatae 15mg, Herba Verbenae 15mg, Panicum miliaceum L. 25mg, Folium Coicis 25mg, Rhizoma Dioscoreae 5mg, Germinatus Phragmitis 5mg, Fructus Mori 5mg, brown sugar 15mg.
The Chinese medicine composition of one boar viral infection resisting, pharmaceutical dosage form is powder agent, its preparation process comprises:
A, all crude drug except fish flour and brown sugar are put into ethanol heating and refluxing extraction;
B, again by medicinal residues water heating and refluxing extraction;
C, above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain medicated powder and mix homogeneously with fish flour and brown sugar.
In described step a, raw medicinal material is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged to filtering and standing; In described step b, the medicinal residues that refined are put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes～1 hour, merges 3 extracting solution filtering and standing.
In described step c, above-mentioned two kinds of filtrates are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.06; The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain raw material medicated powder and mix homogeneously with fish flour and brown sugar.
Every 10kg body weight is taken 10-20g orally, sneaks into feedstuff; While having disease, be used in conjunction 5-7 days, during without disease, medication in a week is maximum twice.
Embodiment 4 formulas:
Fish flour 75mg, Massa Medicata Fermentata 18mg, Herba Lobeliae Chinensis 18mg, Fructus Momordicae charantiae 18mg, Radix Polygoni Multiflori 18mg, Rhizoma alpiniae pumilae 18mg, Radix ampelopsis brevipedunculatae 18mg, Herba Verbenae 18mg, Panicum miliaceum L. 28mg, Folium Coicis 28mg, Rhizoma Dioscoreae 8mg, Germinatus Phragmitis 8mg, Fructus Mori 8mg, brown sugar 18mg.
The Chinese medicine composition of one boar viral infection resisting, pharmaceutical dosage form is powder agent, its preparation process comprises:
A, all crude drug except fish flour and brown sugar are put into ethanol heating and refluxing extraction;
B, again by medicinal residues water heating and refluxing extraction;
C, above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain medicated powder and mix homogeneously with fish flour and brown sugar.
In described step a, raw medicinal material is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged to filtering and standing; In described step b, the medicinal residues that refined are put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes～1 hour, merges 3 extracting solution filtering and standing.
In described step c, above-mentioned two kinds of filtrates are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.06; The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain raw material medicated powder and mix homogeneously with fish flour and brown sugar.
Every 10kg body weight is taken 10-20g orally, sneaks into feedstuff; While having disease, be used in conjunction 5-7 days, during without disease, medication in a week is maximum twice.
Embodiment 5 formulas:
Fish flour 80mg, Massa Medicata Fermentata 20mg, Herba Lobeliae Chinensis 20mg, Fructus Momordicae charantiae 20mg, Radix Polygoni Multiflori 20mg, Rhizoma alpiniae pumilae 20mg, Radix ampelopsis brevipedunculatae 20mg, Herba Verbenae 20mg, Panicum miliaceum L. 30mg, Folium Coicis 30mg, Rhizoma Dioscoreae 10mg, Germinatus Phragmitis 10mg, Fructus Mori 10mg, brown sugar 20mg.
Preparation method is identical with embodiment 1 with usage and dosage.
pharmacology's toxicity test
aggregate toxicity experiment:
The oral powder agent of Chinese medicine composition of the present invention and honey refining pill respectively to mice by 7.69,19.18 and 15 weeks (1.0ml/100g body weight of 43.21g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: Chinese medicine composition of the present invention all has no significant effect indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after the oral powder agent of Chinese medicine composition of the present invention and honey refining pill are to rat long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
clinical trial
480 health pig (male and female half and half, body weight is between 150kg～200kg) are divided into four groups at random,
Group I is normal healthy controls group,
Group II is counteracting toxic substances matched group,
Group III is the test group of taking the Chinese medicine composition 1 that embodiment 3 makes,
Group IV is to take the test group of the Chinese medicine composition 2 that embodiment 4 makes,
Group I only feeds with normal feedstuff Semen Tritici aestivi,
Group II uses the normal feedstuff Semen Tritici aestivi identical with normal healthy controls group to feed, not administration after counteracting toxic substances,
Group III uses the normal feedstuff Semen Tritici aestivi identical with normal healthy controls group to feed with group IV, and after counteracting toxic substances occurs high fever syndrome typical clinical symptom in 48 hours, in the drinking-water in test group, sneak into Chinese medicine composition 1 and the Chinese medicine composition 2 that embodiment 3 and embodiment 4 make, every day, Chinese medicine composition that every pig is joined was suitable with 1.5 grams of raw material of Chinese medicine doses; Each organizes pig free choice feeding, drinking-water, Routine Management; Raise identical natural law, every day 9:00 and observe disease pig symptom during 16:00, dead pig is weighed, anatomic observation pathological change, and perform itemized record, to test, carried out not dead pig being weighed, being dissected in ten days, and recorded pathological changes situation, after having tested, test mortality rate, cure rate, effective percentage are carried out to data statistics, and concrete outcome is in Table 1.
Table 1
| ? | Sick pig number | Death toll | Cure number | Significant figure | Mortality rate % | Cure rate % | Effective percentage % |
| Group I | 0 | 0 | - | - | 0 | - | - |
| Group II | 120 | 98 | - | - | 81.7% | - | - |
| Group III | 120 | 10 | 102 | 110 | 8.33% | 85.0% | 91.7% |
| Group IV | 120 | 4 | 113 | 116 | 3.33% | 94.2% | 96.7% |
In this experimentation, all symptom death that occurs high fever syndrome at duration of test, the ill apparition person of necropsy, is judged to and infects death.
Effectively after medication, dead pig be not effectively, the percentage rate that every group of survival pig number accounts for test pig number be effective percentage recovery from illness after medication, it is normal that the mental status, appetite etc. are recovered, and all belongs to recovery from illness, the percentage rate that the pig number of fully recovering accounts for test pig number is cure rate.
From table 1, we can find out, adopt Chinese medicine composition of the present invention to have significant curative effect to high fever syndrome.
For example: in October, 2012,180 growing and fattening pigs of main Liu's cultivation are raiseeed Sishui County by Shandong Province, all morbidities, affected pig fervescence reaches 40 ℃～42 ℃, and be and delay pattern of fever, anorexia, bradykinesia, is reluctant activity.Visible nasal secretion increases subsequently, cough, and dyspnea, visual mucosa is pale, jaundice.The feces initial stage is stiff and with mucus and mucosa, and constipation and diarrhoea alternately occur.Auricle, afterbody and limb end skin cyanosis, be kermesinus or aubergine.Clinical diagnosis is highly pathogenic PRRS, and ill pig is fed by 1.5g/kg body weight dosage batch mixing, 7 days courses for the treatment of, is used in conjunction 10 courses for the treatment of, final dead 5, cure 175, and cure rate is 92.2%, follows up a case by regular visits to so far not recurrence.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (7)
1. the Chinese medicine composition of a boar viral infection resisting, is characterized in that: be to be made by following weight portion raw material:
Fish flour 50-80 part, Massa Medicata Fermentata 10-20 part, Herba Lobeliae Chinensis 10-20 part, Fructus Momordicae charantiae 10-20 part, Radix Polygoni Multiflori 10-20 part, Rhizoma alpiniae pumilae 10-20 part, Radix ampelopsis brevipedunculatae 10-20 part, Herba Verbenae 10-20 part, Panicum miliaceum L. 20-30 part, Folium Coicis 20-30 part, Rhizoma Dioscoreae 1-10 part, Germinatus Phragmitis 1-10 part, Fructus Mori 1-10 part, brown sugar 10-20 part.
2. the Chinese medicine composition of a boar viral infection resisting according to claim 1, is characterized in that: be to be made by following weight portion raw material:
Fish flour 55-75 part, Massa Medicata Fermentata 12-18 part, Herba Lobeliae Chinensis 12-18 part, Fructus Momordicae charantiae 12-18 part, Radix Polygoni Multiflori 12-18 part, Rhizoma alpiniae pumilae 12-18 part, Radix ampelopsis brevipedunculatae 12-18 part, Herba Verbenae 12-18 part, Panicum miliaceum L. 22-28 part, Folium Coicis 22-28 part, Rhizoma Dioscoreae 2-8 part, Germinatus Phragmitis 2-8 part, Fructus Mori 2-8 part, brown sugar 12-18 part.
3. the Chinese medicine composition of a boar viral infection resisting according to claim 1, is characterized in that: the Chinese medicine composition of a boar viral infection resisting is to be made by following weight portion raw material:
60 parts of fish flour, 15 parts of Massa Medicata Fermentata, 15 parts of Herba Lobeliae Chinensis, 15 parts, Fructus Momordicae charantiae, 15 parts of Radix Polygoni Multiflori, 15 parts of Rhizoma alpiniae pumilaes, 15 parts of Radix ampelopsis brevipedunculataes, 15 parts of Herba Verbenae, 25 parts of Panicum miliaceum L., 25 parts of Folium Coicis, 5 parts of Rhizoma Dioscoreaes, 5 parts of Germinatus Phragmitiss, 5 parts, Fructus Mori, 15 parts, brown sugar.
4. the Chinese medicine composition of a boar viral infection resisting according to claim 1, is characterized in that: the dosage form of pharmaceutical preparation is honey refining pill, and its preparation method comprises:
A, first Fructus Mori, Germinatus Phragmitis, Rhizoma Dioscoreae, Fructus Momordicae charantiae ovendry power are broken into powder;
B, the surplus stock medicine of getting except brown sugar and fish flour are again put into soak with ethanol, and heat is extracted 2 times, become extractum shape, are component 1;
C, medicinal residues extracting in water 1 time, thickening filtration is extractum shape, is component 2;
D, above-mentioned two kinds of extractum are condensed into pasty state, add powder that a step obtains and fish flour, brown sugar, add Mel and be twisted into pill.
5. the Chinese medicine composition of a boar viral infection resisting according to claim 4, it is characterized in that: in described step b, get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-10 doubly to measure, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, extract active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, stand for standby use, become component 1, in described step c, medicinal residues add 5-10 times of water gaging and soak 1-2 hour, within 1-1.5 hour, extract 1 time, as component 2.
6. the Chinese medicine composition of a boar viral infection resisting according to claim 1, is characterized in that: pharmaceutical dosage form is powder agent, and its preparation process comprises:
A, all crude drug except fish flour and brown sugar are put into ethanol heating and refluxing extraction;
B, again by medicinal residues water heating and refluxing extraction;
C, above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain medicated powder and mix homogeneously with fish flour and brown sugar.
7. the Chinese medicine composition of a boar viral infection resisting according to claim 6, is characterized in that: in described step a, raw medicinal material is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged to filtering and standing; In described step b, the medicinal residues that refined are put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes～1 hour, merges 3 extracting solution filtering and standing;
In described step c, above-mentioned two kinds of filtrates are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.06; The macroporous adsorptive resins that above-mentioned filtrate is 10L through volume, first use deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain raw material medicated powder and mix homogeneously with fish flour and brown sugar.
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| CN104667128A (en) * | 2015-03-13 | 2015-06-03 | 聊城职业技术学院 | Traditional Chinese medicinal preparation for preventing and controlling porcine reproductive and respiratory syndrome, and preparation method for traditional Chinese medicinal preparation |
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| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
| CN103355543A (en) * | 2013-07-30 | 2013-10-23 | 山东新希望六和集团有限公司 | Piglet forage |
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| CN101642512A (en) * | 2009-09-09 | 2010-02-10 | 陈焕文 | Chinese herbal medicine for preventing and treating pestilence of pigs, fowls and fishes |
| CN101695342A (en) * | 2009-10-23 | 2010-04-21 | 孟祥合 | Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease |
| CN103355543A (en) * | 2013-07-30 | 2013-10-23 | 山东新希望六和集团有限公司 | Piglet forage |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104667128A (en) * | 2015-03-13 | 2015-06-03 | 聊城职业技术学院 | Traditional Chinese medicinal preparation for preventing and controlling porcine reproductive and respiratory syndrome, and preparation method for traditional Chinese medicinal preparation |
| CN104667128B (en) * | 2015-03-13 | 2019-03-12 | 聊城职业技术学院 | A kind of Chinese materia medica preparation and preparation method thereof for preventing and treating pig blue-ear disease |
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