CN104667128B - A kind of Chinese materia medica preparation and preparation method thereof for preventing and treating pig blue-ear disease - Google Patents

Abstract

The invention discloses a kind of Chinese materia medica preparations and preparation method thereof for preventing and treating pig blue-ear disease, are made of following Chinese medicine material: venushair fern, subprostrate sophora, alternanthera pierce amaranth, fructus amomi, herba taxilli, ford dutchmanspipe root or herb, berberis poiretii, sweet wormwood, beggar-ticks part, dandelion, corn stigma, Prunella vulgaris and acuteleaf caper root.The present invention is using common Chinese herbal medicine as raw material, medicinal material compatibility selected by Chinese materia medica preparation of the present invention is suitable, meet traditional Chinese medicine and modern medicine research theory, all kinds of raw medicinal materials not only have significant curative effect to all kinds of symptom caused by highly pathogenic PRRS, and play synergistic effect between each other, bring out the best in each other, effectively improve the immunity of body, long action time, safe without toxic side effect have good effect to highly pathogenic PRRS is prevented and treated.

Description

A kind of Chinese materia medica preparation and preparation method thereof for preventing and treating pig blue-ear disease

Technical field

The invention belongs to veterinary medicament field, in particular to a kind of Chinese materia medica preparation for preventing and treating pig blue-ear disease and its preparation side Method.

Background technique

Pig blue-ear disease (PRRS) is to belong to artery with caused by respiratory complication (being commonly called as blue otopathy) virus as pig breeding Scorching Viraceae, Arterivirus, with sow breeding difficulty, premature labor, miscarriage and stillborn foetus, piglet and bred pigs Respiratory symptoms For main feature.Serious case may occur in which depressed, expiratory dyspnea etc., because of anoxic of having difficulty in breathing, causes have sharp ears, indigo plant is presented in one's ear Purple, therefore it is " blue otopathy ".

Pig high-pathogenicity blue ear disease mostly occurs in the high temperature season of late spring, early summer, especially severe in feeding environment, pig house Aeration-cooling bad, hot humid, the excessive decentralized household of stocking density and small-sized pig farm are multiple, and high fever is presented in infected pig (41 DEG C~42 DEG C), spirit is depressed, and sleeping ground does not rise, appetite stimulator, rubefaction, eye conjunctivitis, palpebral edema；Asthma, stream nose Tears, cough；There is constipation, diarrhea；Part pig rear quarters is powerless, cannot stand or incoordination etc..Infected pregnant sow essence Refreshing depressed, off feed, body temperature is temporary higher, and different degrees of expiratory dyspnea, heat is abnormal or infertile, and farrowing sow is early Production, miscarriage, stillborn foetus, monster, weak tire etc..

The prior art there is no effective special for treating medicine to this disease at present, and common treatment medication is antiviral Western medicine, Some antiviral Western medicine have certain therapeutic effect to blue-ear disease of pig, but in recent years, forbid in veterinary drug using containing antiviral The treatment difficulty of the Western medicine of composition, pig blue-ear disease obviously increases.The curative effect of the Chinese materia medica preparation of the blue otopathy of the treatment of the prior art is not Good, higher cost, Chinese medicine are traditional rarities of China, and with a long history, from a wealth of sources, cheap, Small side effects, Chinese medicine is more next More for prevention and treatment to Animal diseases in modern farming production, it is badly in need of a kind of good effect of developmental research, at low cost at present Prevention and treatment pig blue-ear disease Chinese materia medica preparation.

Summary of the invention

It more effectively has no toxic side effect the purpose of the present invention is to provide a kind of, it is free of contamination, it is low in cost, have The Chinese materia medica preparation of synergistic effect and its preparation method.

In order to solve the above technical problems, the technical scheme is that

A kind of Chinese materia medica preparation for preventing and treating pig blue-ear disease, is made: venushair fern 30-38 of the Chinese medicine material of following parts by weight Part, 23-32 parts of subprostrate sophora, 30-43 parts of alternanthera, amaranth 25-40 parts of thorn, 15-20 parts of fructus amomi, 10-20 parts of herba taxilli, ford dutchmanspipe root or herb 28-36 parts, 28-40 parts of berberis poiretii, 40-50 parts of sweet wormwood, 25-35 parts of beggar-ticks, 32-45 parts of dandelion, corn stigma 42-50 Part, 10-20 parts of Prunella vulgaris, 5-15 parts of acuteleaf caper root.

Preferably, a kind of Chinese materia medica preparation for preventing and treating pig blue-ear disease, is made: venushair fern of the Chinese medicine material of following parts by weight 32-36 parts, 25-28 parts of subprostrate sophora, 35-40 parts of alternanthera, amaranth 30-35 parts is pierced, 18-20 parts of fructus amomi, 15-18 parts of herba taxilli, is led to Tiger 30-35 parts of city, 30-35 parts of berberis poiretii, 42-46 parts of sweet wormwood, 28-32 parts of beggar-ticks, 38-42 parts of dandelion, corn stigma 45- 50 parts, 12-18 parts of Prunella vulgaris, 5-10 parts of acuteleaf caper root.

It is further preferred that a kind of Chinese materia medica preparation for preventing and treating pig blue-ear disease, is made of the Chinese medicine material of following parts by weight: 35 parts of venushair fern, 26 parts of subprostrate sophora, 38 parts of alternanthera, 33 parts of amaranth of thorn, 19 parts of fructus amomi, 16 parts of herba taxilli, 32 parts of ford dutchmanspipe root or herb, spire 32 parts of barberry, 45 parts of sweet wormwood, 30 parts of beggar-ticks, 40 parts of dandelion, 48 parts of corn stigma, 14 parts of Prunella vulgaris, 6 parts of acuteleaf caper root.

The Chinese materia medica preparation of the prevention and treatment pig blue-ear disease the preparation method comprises the following steps: the raw materials of each parts by weight is mixed, 10-30 is added The water of amount again, heating extraction 1-4 times, each 0.5-5h, filtering, merging filtrate are concentrated, dry, add pharmaceutically acceptable Auxiliary material obtains.

Medication is every 1 dose of pig daily, divides 2 times and feeds, and 1 dose of Chinese materia medica preparation of the invention is 200g.

Pharmacology analysis Chinese medicine compound prescription of the invention is according to traditional medicine and modern medical analysis, and pharmacological property and pharmacological action are such as Under:

Venushair fern is the herb of adiantaceae plant venushair fern (Adiantum capillus-veneris Linn.), again Name pig hair seven, rock palm fibre (vegetation just side), the comprehensive grass of pig (Tian Bao book on Chinese herbal medicine), bermudagrass herb etc., be distributed in East China, Central-South, southwestern and Hebei, The ground such as Shanxi, Shaanxi and Gansu, it is bitter, cool in nature, have effects that heat-clearing is antiviral, promoting diuresis for stranguria, cure mainly fever, cough with lung heat, Diarrhea due to damp-heat, dysentery, stranguria with turbid discharge, leukorrhagia, acute mastitis, scrofula, serious case of furuncle etc..Venushair fern complex chemical composition contains flavonoids, triterpene The ingredients such as class, Phenylpropanoid Glycosides, alicyclic, carotenoid, volatile oil, alkaloid, cardiac glycoside, carbohydrate, tan class, phenols, steroidal.

Subprostrate sophora, alias: mountain Soybean Root, yellow knot (" Empirical formula "), sweetclover-like milkvetch herb (" Chinese medicine handbook ").Former plant root of subprostrate sophora Also known as: sophora subprostrata；Prescription name: beans root, subprostrate sophora, root of subprostrate sophora, southern beans root, rhizoma menispermi, sweetclover-like milkvetch herb etc..Nature and flavor: bitter, cold, channel tropism Enter the heart, lung, large intestine three to pass through.The harvesting of medicinal material and storage: excavating between 4~May or 8~September, removes cauline leaf and fibrous root, cleans, and shines It is dry.Effect: relieving inflammation or internal heat, and detoxifies, and reduces swelling, analgesic.The major functions: retropharyngeal abscess is controlled, and sore-throat, sore throat, swelling and aching of gum, the full heat-syndrome cough of asthma, jaundice, under Dysentery, haemorrhoids, heat is swollen, the favus of the scalp, scabies, snake, worm, dog bite etc..

Alternanthera, alias: babysbreath, shrimp clamp dish, white flower son, sessile alternanthera herb, swollen Qi chrysanthemum, buffalo knee, Latin literary fame: Alternantherasessilis(L.)DC..Nature and flavor: it is micro-sweet, light, it is cool.Containing there are many antiviral effective components, wherein 2 One 3 monomethyl anthraquinone of monohydroxy, alternanthera element, panax japonicus glycosides, trans-ferulaic acid base tyrasamine have obvious antiviral activity. Major function: clearing heat and cooling blood, inducing diuresis and reducing edema, detoxification is antipruritic.For dysentery, nosebleed epistaxis, hemoptysis, hematochezia, urethritis, pharyngitis, mammary gland Inflammation, difficult urination；Sore furuncle poison, eczema, dermatitis, ringworm of the body, venomous snake bite etc. are controlled in external application.

Amaranth is pierced, amaranth is pierced, also known as: Herba seu Radix Amaranrhi (Radix Seu Herba Amaranthi Spinosi), amaranth, Latin literary fame: Amaranthus spinosus. nature and flavor: it is sweet, light, It is cool.Enter lung, liver two passes through.Major function: clearing heat and promoting diuresis, removing toxicity for detumescence, cooling blood and hemostasis.

Fructus amomi, fructus amomi (Classification system: Amomum villosum Lour.) nickname: Fructus Amomi, Changtai fructus (good fortune Build) also known as cardamom, perennial herb.It is the fruits and seeds of Perenniporia martius zingiberaceous plant, is the fragrant simply of Chinese medicine Fragrance medicinal material.Nature and flavor: acrid in flavour and warm in nature.Enter spleen, stomach meridian.Mainly act on stomach and spleen, can promoting the circulation of qi seasoning, stomach function regulating is amusing.

Herba taxilli is the dry zone base of leaf of Loranthaceae plant herba taxilli Taxillus chinensis (DC.) Danser. Branch.Winter to secondary spring is tapped, and removes thick stem, dissection is dry, or drying after steaming.Nature and flavor: it is bitter, sweet, it is mild-natured.Channel tropism: liver, kidney Through.There are wind-damp dispelling, nourishing liver and kidney, strengthening the bones and muscles, the effect of miscarriage prevention member, for blood under vaginal bleeding during pregnancy, the diseases such as threatened abortion.

Alias: five Hu Tongcheng, ford dutchmanspipe root or herb centering grass, lofty or bottomless rattan, dissipates greatly blood, blood Betel, Latin literary fame: Aristolochia Fordiana Hemsl. Aristolochiaceae, Aristolochia herbaceous species；Nature and flavor: bitter acrid in flavour and warm in nature, channel tropism: lung；Stomach；Kidney channel.Function master It controls: wind-dispelling；Analgesia；Detumescence；Removing toxic substances.Main treating rheumatic ostealgia；Epigastric pain；Abdominal pain；Sphagitis；Traumatic injury；Child convulsion；Poisonous snake stings Wound.

Berberis poiretii, berberis poiretii (scientific name: Berberis poiretii) are the plants of Berberidaceae Berberis, and root, stem enter Medicine.Hardship is trembled with fear.It is clearing heat and detoxicating, stomach invigorating.Its chemical component barberry having has the effects that anti-inflammation and sterilization, antiviral.For spitting It rushes down, indigestion, dysentery, coughs, cholecystitis, hot eyes, aphtha, nameless sores or boils, eczema, burn, vascular hypertension.

Sweet wormwood: nature and flavor and channel tropism: it is bitter, it is pungent, it trembles with fear.Return liver, gallbladder channel, three burnt, kidney channels.Major function: clear abnormal heat, cool blood are removed It steams, relieving summer-heat, preventing malaria.It generates heat for summer-heat evil, fever due to yin deficiency, night fever abating at dawn, hectic fever due to yin labor heat, malaria fever and chills, jaundice with damp-heat pathogen.

Beggar-ticks, scientific name: Bidens pilosa L., draft, ground are raw.Property slightly cold, mildly bitter flavor, return liver, lung, large intestine channel, Have effects that clearing heat and detoxicating, blood-stasis-dissipating blood-circulation-promoting, cures mainly the infection of the upper respiratory tract, abscess of throat, acute appendicitis, acute icteric liver Boil, venomous snake bite, treating swelling and pain by traumatic injury are controlled in inflammation, gastroenteritis, pain in rheumatoid joints, malaria, external application.

Dandelion, Classification system: Taraxacum mongolicum Hand.-Mazz., composite family, Dandelion are perennial Herbaceous plant.Nature and flavor: bitter sweet is trembled with fear.Channel tropism: enter liver, stomach meridian.Dandelion point can change heat toxin, Detoxicating food-poisoning, and core of reducing swelling treats serious case of furuncle cream The function that carbuncle, all purging intense heat are set up, controls that stomach is weak, indigestion, chronic gastritis, gasteremphraxis pain.Mononuclear macrophage can be promoted (to there is phagocytosis The effect of bacterial virus), enhance Abwehrkraft des Koepers.

Corn stigma, also referred to as maize palpus.It is sweet in flavor mild-natured, there is the effects of inducing diuresis to remove edema, blood pressure lowering, hemostasis, cholagogue, can treat more Kind disease, such as control acute nephritis.There are also appetizing effects for corn stigma.It is from a wealth of sources, it is low in cost, containing plurality of active ingredients, Improve immunity of organisms.

Prunella vulgaris, nature and flavor: it is pungent, bitter, it trembles with fear.Return liver, gallbladder channel.Acidity of the herb containing tool anti human immune deficiency virus (HIV) is more Grain Polysaccharides from Prunella vulgaris L (prunellin), also contains oleanolic acid, ursolic acid, and oleanolic acid is the saponin of glucoside member, rutin (rutin), hyperin (hyperoside) enhances immunity of organisms, clearing heat-fire, improving eyesight, mass dissipating and swelling eliminating.

Acuteleaf caper root, also known as: only tiger dragon, landing golden pheasant, strangles youngster's root, Xia Dongdi, falls bar potato button, film leaf Capparis Spirrosa. Root, leaf hyoscine, taste bitter and cold have eliminating inflammation and expelling toxin, analgesia, treat the effect of lung cough-relieving.

Chinese veterinarian thinks that blue otopathy category Epidemic Febrile Disease accumulates product to be damp and hot, and caused by heat toxin enters defensive-qi-nutrient-blood, heat symptoms caused by an exopathgen are to suffer from, scorching The upper, skin that burns, the saliva that burns, urgent blood are outgoing；Wet turbid interior heap soil or fertilizer over and around the roots, accumulates air resister, retention of water-damp, internal organs disturbance in ascending and descending.

It is venushair fern bitter in we, cool in nature, containing flavonoids, triterpenes, Phenylpropanoid Glycosides, alicyclic, carotenoid, wave The ingredients such as hair oil, alkaloid, cardiac glycoside, carbohydrate, tan class, phenols, steroidal, have the effect of antiviral heat-clearing, promoting diuresis for stranguria；Lotus Sub- grass, nature and flavor: it is micro-sweet, light, it is cool；Containing there are many antiviral effective component, 2- hydroxy-3-methyl anthraquinones, alternanthera element, ring Join glycosides, trans-ferulaic acid base tyrasamine with obvious antiviral activity, there is clearing heat and cooling blood, inducing diuresis and reducing edema, detoxification is antipruritic, iron Line fern and alternanthera are monarch drug in a prescription altogether.

Subprostrate sophora is bitter, cold, has and relieves inflammation or internal heat, and detoxifies, detumescence, purging fire and cooling blood, analgesic.Pierce amaranth, sweet, light, cool clearing heat and promoting diuresis, solution Poison detumescence, cooling blood and hemostasis；Herba taxilli, bitter, sweet, mild-natured, wind-damp dispelling, nourishing liver and kidney, strengthening the bones and muscles, the effect of miscarriage prevention member；Spire is small Bark of a cork tree, the chemical component barberry having have the effects that anti-inflammation and sterilization, antiviral；The subprostrate sophora, thorn amaranth, herba taxilli and spire are small Bark of a cork tree is ministerial drug altogether, and auxiliary monarch drug in a prescription preferably plays a role.

Assistant is clearing heat and detoxicating with bitter cool sweet wormwood, acuteleaf caper root, Prunella vulgaris, dandelion, and surname dissipate is thoroughly evil；This and beggar-ticks dissipate The stasis of blood invigorate blood circulation phase factor, assistant help for；The ford dutchmanspipe root or herb of detumescence wind-dispelling in side, enters taste warp, and middle benefit gas disappears by trembling with fear with 5 diuresis of corn stigma phase Swollen, cooling blood and purging heat.

Fructus amomi be make medicine, it is acrid in flavour and warm in nature, can promoting the circulation of qi seasoning, coordinating the drug actions of a prescription.All medicines share plays inrigorating qi and promoting blood circulation, clearing heat and detoxicating altogether Function.We have stronger antipyretic, anti-inflammatory and anti-allergic effects.

The present invention is using common Chinese herbal medicine as raw material, and medicinal material compatibility selected by Chinese materia medica preparation of the present invention is suitable, meets Chinese medicine Medicine and modern medicine research theory, all kinds of raw medicinal materials not only have significant treatment to all kinds of symptom caused by highly pathogenic PRRS Effect, and synergistic effect is played between each other, it brings out the best in each other, effectively improves the immunity of body, long action time is safe and non-toxic Side effect has good effect to highly pathogenic PRRS is prevented and treated.According to clinical verification, cure rate is up to 91.43%, curative effect is favourable, cheap, and raiser can promote and apply.

Specific embodiment

Embodiment 1

A kind of Chinese materia medica preparation for preventing and treating pig blue-ear disease, is made: venushair fern 35g, mountain of the Chinese medicine material of following parts by weight Beans root 26g, alternanthera 38g pierce amaranth 33g, fructus amomi 19g, herba taxilli 16g, ford dutchmanspipe root or herb 32g, berberis poiretii 32g, sweet wormwood 45g, ghost Needle grass 30g, dandelion 40g, corn stigma 48g, Prunella vulgaris 14g, acuteleaf caper root 6g.The preparation method comprises the following steps: by each of above-mentioned parts by weight The water of 10 times of amounts is added in raw material mixing, and heating extraction 2 times, each 1h, filtering, merging filtrate is concentrated, and spray drying adds The dextrin of 4wt% mixes, and water is added to pelletize, dry, and granule is made.

Embodiment 2

A kind of Chinese materia medica preparation for preventing and treating pig blue-ear disease, is made of the Chinese medicine material of following parts by weight: 32 parts of venushair fern, mountain 25 parts of beans root, 35 parts of alternanthera, 30 parts of amaranth of thorn, 18 parts of fructus amomi, 15 parts of herba taxilli, 30 parts of ford dutchmanspipe root or herb, 30 parts of berberis poiretii, sweet wormwood 42 parts, 28 parts of beggar-ticks, 38 parts of dandelion, 45 parts of corn stigma, 12 parts of Prunella vulgaris, 5 parts of acuteleaf caper root.The preparation method comprises the following steps: being added The water of 20 times of amounts, heating extraction 3 times, each 0.5h, filtering, merging filtrate is concentrated, spray drying, adds the dextrin of 4wt% mixed It is even, add water to pelletize, it is dry, granule is made.

Embodiment 3

A kind of Chinese materia medica preparation for preventing and treating pig blue-ear disease, is made: venushair fern 32-36 of the Chinese medicine material of following parts by weight Part, 28 parts of subprostrate sophora, 40 parts of alternanthera, 35 parts of amaranth of thorn, 20 parts of fructus amomi, 18 parts of herba taxilli, 35 parts of ford dutchmanspipe root or herb, berberis poiretii 35 Part, 46 parts of sweet wormwood, 32 parts of beggar-ticks, 42 parts of dandelion, 50 parts of corn stigma, 12-18 parts of Prunella vulgaris, 10 parts of acuteleaf caper root.Preparation Method are as follows: the water or ethyl alcohol of 30 times of amounts is added, heating extraction 2 times, each 1h, filtering, merging filtrate is concentrated, and spray drying adds The dextrin of 4wt% mixes, and water is added to pelletize, dry, and granule is made.

The present invention is to provide a kind of prevention and treatment pig blue-ear disease Chinese materia medica preparations, and to prove its safety, inventor is used by upper It states the pulvis that the method provided in embodiment is prepared and has carried out toxicology, result of study is as follows:

Pharmacological toxicity test

1, acute toxicity test

Application mouse carries out acute toxicity testing and shows: Mouse oral stomach-filling Chinese materia medica preparation granule of the invention, Under 488.8g crude drug/kg dosage, there is light activity reduction in mouse after administration, restores within 1 hour or so normal, continuously sees after administration It examines 7 days, none animal dead, overall health of patients, diet, to take the photograph water, urine and body weight increase normal, the results showed that small The maximum dosage-feeding of mouse oral administration gavage Chinese materia medica preparation of the invention be 488.8g crude drug/kg/d (50 > 488.8g crude drug of LD/ kg).The daily total amount of clinical medication of Chinese materia medica preparation of the invention is 0.1g crude drug/kg/d；Prompt the acute toxicity low, clinic is used Medicine safety.

2, long term toxicity test

SD rat is selected, the Chinese materia medica preparation pulvis of the invention of various concentration (18.0,6.0,2.0g crude drug/kg) is given, Daily stomach-filling is primary, and continuous 90 days, 1/2 animal (half male and half female) was killed in each group work in 24 hours after the last administration, remaining 1/2 animal after Work is killed after continuous observation 2 weeks.During test observe animal appearance, general behavior, food intake, weight change, after administration 90 days and Be discontinued 2 weeks progress hematologies (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the index checkings such as Histopathology.Test knot Fruit shows: Chinese materia medica preparation of the invention is good in high, medium and low dosage group animal general state, appearance signs, behavioral activities, into Appetite and body weight increase variation without exception；Three dosage groups and control group hematological examination, blood biochemical analysis, urine biochemistry inspection It looks between normal range (NR), group without significant difference；Each group main organs histopathological examination is shown no obvious abnormalities.These parameters It is discontinued after 2 weeks and also has no change.The dose of this test is respectively the 180 of clinical medicine dose, 60,20 times, is tied according to test Fruit Chinese materia medica preparation of the invention is in administration in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) continuous 90 days to rat It has no significant effect, without specific toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, prompts this The dose safety of the Chinese medicine preparation clinical practice of invention is higher.

3, SD rat is selected, the Chinese materia medica preparation of the invention for giving various concentration (18.0,6.0,2.0g crude drug/kg) dissipates Agent, daily stomach-filling is primary, and continuous 90 days, 1/2 animal (half male and half female) was killed in 24 hours each groups work after the last administration, remaining is 1/2 dynamic Work is killed after object continues observation 2 weeks.Appearance, general behavior, the food intake, weight change that animal is observed during test, 90 after administration It and be discontinued 2 weeks progress hematologies (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the index checkings such as Histopathology.Examination Test the result shows that: Chinese materia medica preparation of the invention is good in high, medium and low dosage group animal general state, and appearance sign, behavior are living Dynamic, food-intake and body weight increase variation without exception；Three dosage groups and control group hematological examination, blood biochemical analysis, urine Biochemical analysis is without significant difference between normal range (NR), group；Each group main organs histopathological examination is shown no obvious abnormalities.On It states after index is discontinued 2 weeks and also has no change.The dose of this test is respectively the 180 of clinical medicine dose, 60,20 times, according to Test result Chinese materia medica preparation of the invention was administered at high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) continuous 90 days Rat is had no significant effect, without specific toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, Prompt the dose safety of Chinese medicine preparation clinical practice of the invention higher.

For the therapeutic effect for further verifying Chinese materia medica preparation of the present invention, inventor has carried out the clinical test for suffering from blue otopathy pig It investigates:

1, material

1.1 animals: Liaocheng of Shandong Province pig farm suffers from pig blue-ear disease sick pig 210.

1.2 test samples: with embodiment 1；Control group medicine: qingwen baidu powder, (a kind of veterinary drug, main ingredient: glutinous rehmannia, water Ox horn, the coptis, cape jasmine, cortex moutan, radix scutellariae, gypsum etc.), authentication code: veterinary drug word (2012) 160685165.

2, method and result

2.1 experimental methods: will be diagnosed as the sick pig of pig blue-ear disease, focuses on isolation house, randomly selects size and patient's condition base This consistent sick pig 210, it is divided into 3 groups, every group 70, the 1st group is 1 prescription group of the present embodiment, and the 2nd group is comparison medicine group, the Three groups are not administration group.Medication is every 1 dose of pig daily, divides 2 times and feeds, feeds the 100g embodiment of the present invention 1 every time Chinese materia medica preparation, administration time are 5 days.The method fed are as follows: Chinese materia medica preparation is mixed into pannage and is fed.

2.2 observation methods: it is observed continuously 20 days from offeing medicine certainly, respectively observes in every morning, afternoon 1 time, carry out in time It observes and records.

The control of 2.3 feeding environments: dry colony house, cleaning, ventilation, feeding, drinking-water and feeding management are kept during test It carries out, is consistent as far as possible according to a conventional method.

2.4 criterion:

(1) cure: sick pig body temperature, body colour, excrement, spirit, appetite restore normal, and do not recur；

(2) effective: sick pig body temperature, body colour, spirit, appetite are gradually restored normally, and dry and hard excrement degree gradually improves or disease Pig is gradually fully recovered, and is recurred again in the observation period；

(3) invalid: after medication, sick pig symptom is simultaneously not alleviated, or even aggravates dead.

For statistical convenience, live pig does not also contrast above-mentioned standard depending on its remission status and is counted in administration group Sort out.

2.5 experimental results: experimental result is shown in Table 1.

Therapeutic effect experimental result table of the table 1 to pig blue-ear disease sick pig

The experimental results showed that, the Chinese materia medica preparation and qingyu defeated poison group that 1 group of the present embodiment are to the effective of test sick pig above Rate and cure rate are all remarkably higher than not administration group, and it is good to illustrate that the present embodiment 1 and qingyu defeated poison group have pig blue-ear disease sick pig Good therapeutic effect；1 pair of the present embodiment effective percentage for testing sick pig and cure rate are superior to qingyu defeated poison group, illustrate at invention Side is better than qingwen baidu powder to the therapeutic effect of pig blue-ear disease.

Above-mentioned, although specific embodiments of the present invention have been described, not to the limit of the scope of the present invention System, those skilled in the art should understand that, based on the technical solutions of the present invention, those skilled in the art do not need to pay The various modifications or changes that creative work can be made out are still within protection scope of the present invention.

Claims (1)

1. a kind of Chinese materia medica preparation for preventing and treating pig blue-ear disease, characterized in that be made of the Chinese medicine material of following parts by weight: venushair fern 35 parts, 26 parts of subprostrate sophora, 38 parts of alternanthera, 33 parts of amaranth of thorn, 19 parts of fructus amomi, 16 parts of herba taxilli, 32 parts of ford dutchmanspipe root or herb, berberis poiretii 32 Part, 45 parts of sweet wormwood, 30 parts of beggar-ticks, 40 parts of dandelion, 48 parts of corn stigma, 14 parts of Prunella vulgaris, 6 parts of acuteleaf caper root, the Chinese medicine The dosage form of preparation is granule, and preparation method includes the following steps: to mix the raw material of each parts by weight, what 10-30 times of addition was measured Water, heating extraction 1-4 times, each 0.5-5h, filtering, merging filtrate are concentrated, dry, add pharmaceutically acceptable auxiliary material, It obtains.