CN105327134A - Traditional Chinese medicine for treating factor VIII deficiency and preparing method thereof - Google Patents
Traditional Chinese medicine for treating factor VIII deficiency and preparing method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating factor VIII deficiency and a preparing method thereof. The traditional Chinese medicine is prepared from cochlearia officinalis, stephanotis chunii, ilex cornuta velamina, camellia, gorse, ventilago leiocarpa benth, auricularia polytricha, ramose scouring rush herb, aizoon stonecrop herb, angelica niyida wolff, platycodon grandiflorum, caragana frutex, fragrant sarcococca herb, herba rubiae yunnanensis, parmelia tinctourium, conic gymnadenia tuber, chlorella and sambucus adnata wall. The traditional Chinese medicine has the advantages that when the traditional Chinese medicine is matched with the substitution therapy for treating factor VIII deficiency, hemostasis and analgesis effects are definite, and the traditional Chinese medicine is capable of becoming effective quickly, free of side effect and convenient to take.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of hemophilia A.
Background technology
Hemophilia is the hemorrhage that one group of hereditary coagulation factors deficiency causes.Thrombin be in human body one group there is the biological activity protein causing blood coagulation, have hemostatic function, main thrombin has 13 kinds, and conventional Roman number is expressed as: I, II ... .XIII (i.e. thrombin one, two ... to 13).If lack a certain thrombin in blood, blood is just not easy to solidify, thus causing bleeding property disease.In China, haemophiliachemophiliac social man group sickness rate is 5 ~ 10,/10 ten thousand, baby's incidence rate about 1/5000.Often there is coagulation disorders in classical haemophilia patient, hemorrhagely can not spontaneously stop after Juvenile onset, spontaneous or slight wound; Thus at wound, haemophilia often of performing the operation, severe patient also can hematostaxis after comparatively aggravating activities.Primary disease is mainly hereditary, and current doctor trained in Western medicine there is no radical treatment, and base therapy measure is alternative medicine, and other drug all has temporary transient anastalsis.
Hemophilia lacks the difference of thrombin kind according to it, can be divided into:
(1), hemophilia A: be cause because thrombin eight (namely VIII) lacks, be also called hemophilia A, be modal hemophilia clinically, account for the 80%-85% of hemophilia number, even higher in some hotspot.
(2), hemophilia B: be due to thrombin nine (i.e. IX) lack cause, be also called hemophilia B, clinical rare compared with hemophilia A, account for about 15% of hemophilia number.
(3), hemophilia C: lack thrombin 11 (namely Ⅺ lacks, abroad also known as making Rosenthal syndrome).Ⅺ deficiency disease is extremely rare in China.
(4), acquired Hemophilia (namely acquired coagulation factor lacks): often because oneself factor causes some thrombin level to decline, or active reduction, as acquired thrombin eight (VIII) deficiency disease, normal owing to self producing VIII factor antibody, cause coagulation disorders, cause acquired Hemophilia (hemophilia A).
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of Chinese medicine and preparation method for the treatment of hemophilia A, and Chinese medicine of the present invention coordinates alternative medicine, and hemostasis and pain-relieving definite effect, toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of hemophilia A, each raw medicinal material of described Chinese medicine comprises: Radix Cochleariae officinalis dish, Stephanotis chunii Tsiang, contribution root, Flos Camelliae Japonicae, Flos Caraganae Sinicae, Radix seu Caulis Verntilaginis Leiocarpae, Auricularia polytricha (Mout) Sacc., Herba equiseti ramosissimi, Herba Sedi Aizoon, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu, Radix Platycodonis, wood caragana, Sarcococca ruscifolia Stapf, Herba Rubiae Yunnanensis, Parmelia saxatilis Ach., Rhizoma Gymnadeniae, chlorella and Herba Sambuci Adnatae.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix Cochleariae officinalis dish 30 ~ 40 parts, Stephanotis chunii Tsiang 15 ~ 25 parts, contribution root 20 ~ 35 parts, Flos Camelliae Japonicae 5 ~ 15 parts, Flos Caraganae Sinicae 10 ~ 20 parts, Radix seu Caulis Verntilaginis Leiocarpae 30 ~ 40 parts, Auricularia polytricha (Mout) Sacc. 5 ~ 15 parts, Herba equiseti ramosissimi 10 ~ 25 parts, Herba Sedi Aizoon 10 ~ 20 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 15 ~ 25 parts, Radix Platycodonis 5 ~ 15 parts, wood caragana 10 ~ 20 parts, Sarcococca ruscifolia Stapf 15 ~ 30 parts, Herba Rubiae Yunnanensis 15 ~ 25 parts, Parmelia saxatilis Ach. 30 ~ 40 parts, Rhizoma Gymnadeniae 5 ~ 15 parts, chlorella 15 ~ 25 parts and Herba Sambuci Adnatae 5 ~ 15 parts.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix Cochleariae officinalis dish 30 ~ 35 parts, Stephanotis chunii Tsiang 15 ~ 20 parts, contribution root 25 ~ 30 parts, Flos Camelliae Japonicae 5 ~ 10 parts, Flos Caraganae Sinicae 10 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 30 ~ 35 parts, Auricularia polytricha (Mout) Sacc. 5 ~ 10 parts, Herba equiseti ramosissimi 15 ~ 25 parts, Herba Sedi Aizoon 10 ~ 15 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 15 ~ 20 parts, Radix Platycodonis 5 ~ 10 parts, wood caragana 10 ~ 15 parts, Sarcococca ruscifolia Stapf 20 ~ 30 parts, Herba Rubiae Yunnanensis 15 ~ 20 parts, Parmelia saxatilis Ach. 30 ~ 35 parts, Rhizoma Gymnadeniae 5 ~ 10 parts, chlorella 15 ~ 20 parts and Herba Sambuci Adnatae 5 ~ 10 parts.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix Cochleariae officinalis dish 34 parts, Stephanotis chunii Tsiang 16 parts, contribution root 29 parts, Flos Camelliae Japonicae 6 parts, Flos Caraganae Sinicae 14 parts, Radix seu Caulis Verntilaginis Leiocarpae 32 parts, Auricularia polytricha (Mout) Sacc. 7 parts, Herba equiseti ramosissimi 18 parts, Herba Sedi Aizoon 13 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 18 parts, Radix Platycodonis 7 parts, wooden caragana 11 parts, Sarcococca ruscifolia Stapf 27 parts, Herba Rubiae Yunnanensis 20 parts, Parmelia saxatilis Ach. 32 parts, Rhizoma Gymnadeniae 5 parts, chlorella 16 parts and Herba Sambuci Adnatae 10 parts.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix Cochleariae officinalis dish 30 parts, Stephanotis chunii Tsiang 20 parts, contribution root 26 parts, Flos Camelliae Japonicae 10 parts, Flos Caraganae Sinicae 11 parts, Radix seu Caulis Verntilaginis Leiocarpae 35 parts, Auricularia polytricha (Mout) Sacc. 5 parts, Herba equiseti ramosissimi 24 parts, Herba Sedi Aizoon 10 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 16 parts, Radix Platycodonis 10 parts, wooden caragana 15 parts, Sarcococca ruscifolia Stapf 23 parts, Herba Rubiae Yunnanensis 15 parts, Parmelia saxatilis Ach. 35 parts, Rhizoma Gymnadeniae 10 parts, chlorella 20 parts and Herba Sambuci Adnatae 6 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Beneficial effect of the present invention: Chinese medicine of the present invention coordinates replacement therapy hemophilia A, and hemostasis and pain-relieving definite effect, instant effect, has no side effect little, taking convenience.
Detailed description of the invention
The invention provides a kind of Chinese medicine for the treatment of hemophilia A, its raw medicinal material comprises: Radix Cochleariae officinalis dish, Stephanotis chunii Tsiang, contribution root, Flos Camelliae Japonicae, Flos Caraganae Sinicae, Radix seu Caulis Verntilaginis Leiocarpae, Auricularia polytricha (Mout) Sacc., Herba equiseti ramosissimi, Herba Sedi Aizoon, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu, Radix Platycodonis, wooden caragana, Sarcococca ruscifolia Stapf, Herba Rubiae Yunnanensis, Parmelia saxatilis Ach. and Herba Sambuci Adnatae.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Radix Cochleariae officinalis dish: [source] medical material Ji Yuan: be the herb of crucifer rock shepherd's purse.[nature and flavor] are pungent; Tepor.[function cures mainly] wind-damp dispelling; Strengthening the spleen and stomach.Main air pain of dampness syndrome; Gout; Dyspepsia is not changed; Toothache; Locked mouth; Vitamin C deficiency.[extracts] " China's book on Chinese herbal medicine "
Stephanotis chunii Tsiang: [another name] false building is logical, the complete large benefit of floral leaf KONGXINCAO, wood.[source] medical material Ji Yuan: be leaf or the root of the black climing rattan of dicotyledon medicine asclepiadaceae plant Stephanotis chunii Tsiang.[nature and flavor] sweet in the mouth; Pungent; Warm in nature.[return through] liver; Kidney channel.[function cures mainly] enriches blood; Invigorate blood circulation; Stimulating milk secretion.Main menoxenia; Dysmenorrhea; Puerperal blood deficiency, hypogalactia.[extracts] " China's book on Chinese herbal medicine "
Contribution root: [another name] Radix Ilicis Cornutae.[source] medical material Ji Yuan: be the root of holly plant Ilex cornuta Lindl..[nature and flavor] are bitter; Cool.[function cures mainly] the liver and the kidney tonifying; Wind and heat dispersing.Main waist knee flaccidity; Arthralgia; Wind syndrome of head; Acute conjunctivitis; Toothache; Urticaria.[extracts] " China's book on Chinese herbal medicine "
Flos Camelliae Japonicae: [another name] black tea flower (" classifying herbal ").[source] is the flower of plant of theaceae Flos Camelliae Japonicae.The Spring Equinox to grain rains is collection period.Generally pluck when a bud just ready to burst, dry or dry, paper using is encapsulated, and puts dry ventilation.[nature and flavor] sweetness and bitterness is pungent, cool.[return through] 1. " book on Chinese herbal medicine is new again ": " enter liver, lung two through ".2. " book on Chinese herbal medicine brief points ": " entering sufficient faint the moon, meridian of Hand-YANG MING ".[function cures mainly] removing heat from blood, hemostasis, dissipating blood stasis, detumescence.Control haematemesis, epistaxis, metrorrhagia, hemorrhoidal hamorrhage, dysentery, stranguria with blood, injury from falling down, scald.[extracts] " Chinese medicine voluminous dictionary "
Flos Caraganae Sinicae: [another name] dam tooth flower (herbal for Relief of Famines), gold magpie flower (" the southern regions of the Yunnan Province book on Chinese herbal medicine "), yellowbird flower (" detailed outline is picked up any lost article from the road "), Flos Caraganae Franchetianae (" vegetation is side just "), Ungula Sus domestica flower (" Fujian traditional herbal medicine "), axe flower, Trionyx sinensis Wiegmann mouth flower (" Zhejiang Chinese medicine handbook "), Yang Quehua (" Shaanxi Chinese herbal medicine ").[source] is the flower of leguminous plant caragana.Mid-April gathers, and dries, mothproof.[nature and flavor] are " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: " slightly warm in nature, taste is sweet ".[return through] " detailed outline is picked up any lost article from the road ": " enter liver, spleen two through ".[function cures mainly] YIN nourishing, and blood, spleen invigorating.Control consumptive fever cough, the dizzy soreness of waist, women's deficiency of vital energy leucorrhea, infantile malnutrition, acute mastitis, injury from falling down.[extracts] " Chinese medicine voluminous dictionary "
Radix seu Caulis Verntilaginis Leiocarpae: [another name] Sinomenium acutum, car pusher enter stone, blue veins rattan (Guangzhou army " conventional Chinese herbal medicine handbook ").Root, stem that [source] is Rhamnaceae plant ventilago leiocarpa.The whole year can adopt, and clean section is dried.[nature and flavor] are sweet, temperature.[function cures mainly] benefiting vital QI and blood, dispelling, collateral-activating.Control deficiency of both QI and blood, rheumatalgia, traumatic injury.Guangzhou army " conventional Chinese herbal medicine handbook ": " rich in nutrition, relaxing muscles and tendons and activating QI and blood in the collateral.Control deficiency of both QI and blood, menoxenia, bones and muscles pain due to rheumatism, numb limbs and tense tendons, traumatic injury ".[extracts] " Chinese medicine voluminous dictionary "
Auricularia polytricha (Mout) Sacc.: [source] Mycophyta Basidiomycetes Tremellales Tremellaceae Auricularia polytricha (Mout) Sacc., is used as medicine with sporophore.[nature and flavor] are sweet, flat.[function cures mainly] fills blood, lung moistening, hemostasis.For Qi and blood deficiency, extremity are twitched, cough due to deficiency of the lung, spitting of blood, spit blood, epistaxis, metrorrhagia, hypertension, constipation.[extracts] " national Chinese herbal medicine compilation "
Herba equiseti ramosissimi: [another name] ventilation grass, eyebrow careless, Herba Eguiseti Debilis, mexicana, Rhizoma seu Herba Elatostematis stewardii, file grass, Herba Equiseti Hiemalis, native Herba Ephedrae, nib grass, wild flax is yellow, file is careless, Rana limnocharis bamboo, lock eyebrow grass, Ephedra sinica, Herba Equiseti Hiemalis, pot lid grass, take over careless, wiping is careless, grinding stone is careless, Radix Scorzonerae Albicaulis, field, corner Chinese scholartree, wild Herba Equiseti Hiemalis, BOJIECAO, KONGXINCAO, synthetism cylinder, numb Artemisia.[source] medical material Ji Yuan: be the herb of Equisetaceae plant Herba Clinopodii Polycephali.[nature and flavor] are sweet; Bitter; Flat; Nontoxic; Be slightly cold.[return through] heart; Liver; Stomach; Urinary bladder channel.[function cures mainly] liver heat removing and eyesight improving; Hemostasis; Inducing diuresis for treating stranguria syndrome; .Main anemopyretic cold; Cough; Conjunctival congestion and swelling pain; Nebula; Epistaxis; Hematuria; Discharging fresh blood stool; Stranguria; Jaundice; Leukorrhagia; Fracture.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Herba Sedi Aizoon: [another name] Herba Senecionis Chrysanthemoidis, the top of a wall Radix Notoginseng, see that blood is loose, blood mountain grass, Pyrola rotundifolia ssp.chinensis, pouring in June.[source] Crassulaceae sengreen Herba Sedi Aizoon or horizontal root Herba sedi kamtschatici, with root or all herbal medicine.Spring and autumn excavates root, cleans and dries.Herb with adopting, or gathers and dries autumn.[nature and flavor] sweet, micro-acid, flat.[function cures mainly] dissipating blood stasis stops blooding, analgesia of calming the nerves.For thrombocytopenic purpura, epistaxis, spits blood, spitting of blood, gingival hemorrhage, digestive tract hemorrhage, metrorrhagia, cardiopalmus, irritated insomnia; Traumatic injury is controlled in external, traumatic hemorrhage, burn and scald.[extracts] " national Chinese herbal medicine compilation "
Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu: [source] medical material Ji Yuan: be the root of samphire Qinghai Radix Angelicae Sinensis.[nature and flavor] sweet in the mouth; Pungent; Warm in nature.[function cures mainly] enriches blood; Invigorate blood circulation; Intestine moistening.Main syndrome of deficiency of blood; Menoxenia; Pain due to blood stasis; Dryness of the intestine constipation.[extracts] " China's book on Chinese herbal medicine "
Radix Platycodonis: [another name] Fu Hu, BAIYAO, profit are if, stalk grass, Lu are as (" WU Pu Bencao "), Fang Tu, Radix Adenophorae Trachelioidis (" not Lu "), Radix Platycodi (" danxi's experiential therapy "), RADIX PLATYCODI (" detailed outline "), large medicine (" medicine will is planted in Jiangsu ").[source] is the root of Campanulaceae Radix Platycodonis.Spring, season in autumn two gather, and real with the autumn person of adopting body weight matter, better quality.Remove Miao Ye after taking, clean earth, namely in immersion, scrape off crust, dry.In case of namely wet weather should dry.[nature and flavor] toil, flat.[return through] enters lung, stomach warp.[function cures mainly] opens lung qi dispersing gas, evacuation of pus of eliminating the phlegm.Control exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery is suffered from abdominal pain." not Lu ": ", except cold and heat, migratory arthralgia, warming middle-JIAO rapid digestion of food, treats laryngopharynx pain for sharp the five internal organs the intestines and stomach, gas of enriching blood ".[extracts] " Chinese medicine voluminous dictionary "
Wood caragana: [source] pulse family wood caragana, is used as medicine with flower.[nature and flavor] liver, flat.[function cures mainly] enriches blood, and invigorates blood circulation.Cure mainly traumatic injury, variola.[extracts] " national Chinese herbal medicine compilation "
Sarcococca ruscifolia Stapf: [another name] Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), Fructus seu semen pruni szechuanicae, wild fan flower, large emaciation due to emotional upset, Rohdea japonica Roth, featherleaf rodgersflower top.[source] Buxaceae Sarcococca plant fragrance osmanthus, with root and fruit medicine.Spring and autumn adopts root; The fruit picking of autumn in summer, cleans and dries or using fresh herb.[nature and flavor] are pungent, bitter, flat.[function cures mainly] root: regulating QI to relieve pain, dispelling, collateral-activating.For acute and chronic gastritis, gastric ulcer, rheumatic arthritis, traumatic injury.Really: replenishing blood and nourishing liver.For dizziness, cardiopalmus, visual deterioration.[extracts] " national Chinese herbal medicine compilation "
Herba Rubiae Yunnanensis: [another name] Rubiayunnanensis (Franch.) Dlels.[source] medical material Ji Yuan: for the aerial parts of grass is wished in Maguireothamnus speciosus Yunnan.[nature and flavor] are sweet; Flat.[function cures mainly] is enriched blood and is invigorated blood circulation; Expelling wind and removing dampness.Main anemia; Dizzy insomnia; Rheumatic arthralgia; Chronic gastritis; Traumatic injury; Menoxenia.[extracts] " China's book on Chinese herbal medicine "
Parmelia saxatilis Ach.: [another name] stone tongue (" vegetation is side just "), breast flower (" the conventional Chinese herbal medicine handbook in the north "), lichens (" Jilin Chinese herbal medicine "), road Garrick (illiteracy name).[source] is the entirety of Flos Mume clothing section plant lichen.The whole year can adopt, and under stone shovel, Ex-all impurity, dries.[nature and flavor] are sweet, cold.[function cures mainly] nourishes blood, improving eyesight, the kidney invigorating, diuresis, heat clearing away, removing toxic substances.Control blurred vision, spit blood, metrorrhagia, lumbocrural pain, urine burning pain, nebulousurine, leucorrhea, burn.[extracts] " Chinese medicine voluminous dictionary "
Rhizoma Gymnadeniae: [another name] Fructus Citri Sarcodactylis ginseng, palm ginseng (" Ningxia Chinese herbal medicine handbook "), hands ginseng (" Shaanxi Chinese herbal medicine "), prosperously draws (Tibetan name).The tuber that [source] is orchid Rhizoma Gymnadeniae and gymnadenia crassinervis Finet.Spring, autumn excavate.Remove stem and leaf and fibrous root, clean, dry, or scalded with boiled water and dry again.[nature and flavor] are sweet, flat.[return through] " Chinese herbal medicine is commonly used in Sichuan ": " enter lung, spleen, stomach through ".[function cures mainly] benefiting vital QI and blood, promoting the production of body fluid to quench thirst.Control cough and asthma due to lung deficiency, asthenia is become thin, neurasthenia, and chronic diarrhea is lost blood, leukorrhagia, and breast is few, chronic hepatitis.[extracts] " Chinese medicine voluminous dictionary "
Chlorella: [source] medical material Ji Yuan: be the frond of chlorella section vegetable protein core chlorella and chlorella.[function cures mainly] clearing away heat and promoting diuresis; Enrich blood.Main edema; Have loose bowels; Hepatitis; Anemia.[extracts] " China's book on Chinese herbal medicine "
Herba Sambuci Adnatae: [another name] showy reiolaena root-bark, Cortex torricelliae tiliifoliae, blood vessel grass, Ramulus Sambuci Williamsii, severe grass, Red Hill flower, Rhizoma seu Herba Elatostematis stewardii, Margarita fiber crops.[source] medical material Ji Yuan: be mouth herb or the root bark of Ren Ke section plant Herba Sambuci Adnatae.[nature and flavor] acrid in the mouth; Sweet; Warm in nature.[return through] returns spleen; Kidney channel.[function cures mainly] dispels the wind; Diuretic; Invigorate blood circulation; Dredging collateral.Main acute and chronic nephritis; Rheumatalgia; Rubella pruritus; Children's's single board computer numbness sequela; Chronic lambago and skelalgia; Sprain stasis of blood pain; Fracture.[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix Cochleariae officinalis dish 30 ~ 40 parts, Stephanotis chunii Tsiang 15 ~ 25 parts, contribution root 20 ~ 35 parts, Flos Camelliae Japonicae 5 ~ 15 parts, Flos Caraganae Sinicae 10 ~ 20 parts, Radix seu Caulis Verntilaginis Leiocarpae 30 ~ 40 parts, Auricularia polytricha (Mout) Sacc. 5 ~ 15 parts, Herba equiseti ramosissimi 10 ~ 25 parts, Herba Sedi Aizoon 10 ~ 20 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 15 ~ 25 parts, Radix Platycodonis 5 ~ 15 parts, wood caragana 10 ~ 20 parts, Sarcococca ruscifolia Stapf 15 ~ 30 parts, Herba Rubiae Yunnanensis 15 ~ 25 parts, Parmelia saxatilis Ach. 30 ~ 40 parts, Rhizoma Gymnadeniae 5 ~ 15 parts, chlorella 15 ~ 25 parts and Herba Sambuci Adnatae 5 ~ 15 parts.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix Cochleariae officinalis dish 30 ~ 35 parts, Stephanotis chunii Tsiang 15 ~ 20 parts, contribution root 25 ~ 30 parts, Flos Camelliae Japonicae 5 ~ 10 parts, Flos Caraganae Sinicae 10 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 30 ~ 35 parts, Auricularia polytricha (Mout) Sacc. 5 ~ 10 parts, Herba equiseti ramosissimi 15 ~ 25 parts, Herba Sedi Aizoon 10 ~ 15 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 15 ~ 20 parts, Radix Platycodonis 5 ~ 10 parts, wood caragana 10 ~ 15 parts, Sarcococca ruscifolia Stapf 20 ~ 30 parts, Herba Rubiae Yunnanensis 15 ~ 20 parts, Parmelia saxatilis Ach. 30 ~ 35 parts, Rhizoma Gymnadeniae 5 ~ 10 parts, chlorella 15 ~ 20 parts and Herba Sambuci Adnatae 5 ~ 10 parts.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix Cochleariae officinalis dish 34 parts, Stephanotis chunii Tsiang 16 parts, contribution root 29 parts, Flos Camelliae Japonicae 6 parts, Flos Caraganae Sinicae 14 parts, Radix seu Caulis Verntilaginis Leiocarpae 32 parts, Auricularia polytricha (Mout) Sacc. 7 parts, Herba equiseti ramosissimi 18 parts, Herba Sedi Aizoon 13 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 18 parts, Radix Platycodonis 7 parts, wooden caragana 11 parts, Sarcococca ruscifolia Stapf 27 parts, Herba Rubiae Yunnanensis 20 parts, Parmelia saxatilis Ach. 32 parts, Rhizoma Gymnadeniae 5 parts, chlorella 16 parts and Herba Sambuci Adnatae 10 parts.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix Cochleariae officinalis dish 30 parts, Stephanotis chunii Tsiang 20 parts, contribution root 26 parts, Flos Camelliae Japonicae 10 parts, Flos Caraganae Sinicae 11 parts, Radix seu Caulis Verntilaginis Leiocarpae 35 parts, Auricularia polytricha (Mout) Sacc. 5 parts, Herba equiseti ramosissimi 24 parts, Herba Sedi Aizoon 10 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 16 parts, Radix Platycodonis 10 parts, wooden caragana 15 parts, Sarcococca ruscifolia Stapf 23 parts, Herba Rubiae Yunnanensis 15 parts, Parmelia saxatilis Ach. 35 parts, Rhizoma Gymnadeniae 10 parts, chlorella 20 parts and Herba Sambuci Adnatae 6 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: tablet
Get Radix Cochleariae officinalis dish 340g, Stephanotis chunii Tsiang 160g, contribution root 290g, Flos Camelliae Japonicae 60g, Flos Caraganae Sinicae 140g, Radix seu Caulis Verntilaginis Leiocarpae 320g, Auricularia polytricha (Mout) Sacc. 70g, Herba equiseti ramosissimi 180g, Herba Sedi Aizoon 130g, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 180g, Radix Platycodonis 70g, wooden caragana 110g, Sarcococca ruscifolia Stapf 270g, Herba Rubiae Yunnanensis 200g, Parmelia saxatilis Ach. 320g, Rhizoma Gymnadeniae 50g, chlorella 160g and Herba Sambuci Adnatae 100g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 325 object micropowders;
3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.26 times, 0.08 times of lactose, the starch of 0.24 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.05 times of magnesium stearate, granulate, tabletting, makes.
Embodiment 2: capsule
Get Radix Cochleariae officinalis dish 300g, Stephanotis chunii Tsiang 200g, contribution root 260g, Flos Camelliae Japonicae 100g, Flos Caraganae Sinicae 110g, Radix seu Caulis Verntilaginis Leiocarpae 350g, Auricularia polytricha (Mout) Sacc. 50g, Herba equiseti ramosissimi 240g, Herba Sedi Aizoon 100g, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 160g, Radix Platycodonis 100g, wooden caragana 150g, Sarcococca ruscifolia Stapf 230g, Herba Rubiae Yunnanensis 150g, Parmelia saxatilis Ach. 350g, Rhizoma Gymnadeniae 100g, chlorella 200g and Herba Sambuci Adnatae 60g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.25:0.35, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 22 ~ 28g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.46g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>42.3 crude drug/kg of the present invention, every day, maximum dosage-feeding was 84.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 7.8g crude drug/day/people, adult body weight in 60KG, average dosage is 0.13g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 25g) oral administration gavage Chinese medicine of the present invention is 651 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to three groups of mices (often organize 20) by 15.26,22.47 and 38.36g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: the hemophiliac that whole 126 routine cases are my Out-patient Department or are in hospital, is male, 14 ~ 45 years old age, wherein, and heavy 26 examples, medium-sized 51 examples, light-duty 37 examples, Subclinical 12 example; 98 examples have family history.Be divided into matched group and treatment group at random, matched group 60 example, is male, 14 ~ 43 years old age, wherein, and heavy 12 examples, medium-sized 24 examples, light-duty 18 examples, Subclinical 6 example; 50 examples have family history.Treatment group 66 example, is male, 15 ~ 45 years old age, wherein, and heavy 14 examples, medium-sized 27 examples, light-duty 19 examples, Subclinical 6 example; 48 examples have family history.Two groups of patients data there was no significant difference in age, severe extent etc., has comparability.
Diagnostic criteria: the diagnostic criteria of hemophilia A: 1. clinical manifestation: male patient has or without family history.Accordance joins stealthy genetic development.Female homozygote type can occur, Ji Shaojian; Joint, muscle, deep tissue are hemorrhage, can be spontaneous.Joint Repeated Hemorrhage causes joint deformity, and deep tissue Repeated Hemorrhage causes false tumor (hematocele).2. lab testing: clotting time (test tube method) severe extends, and moderate can be normal, slight and Subclinical is normal.Activated partial clotting time, severe obviously extends, and can be corrected by normal fresh plasma and adsorbed plasma, slightly slightly prolongation or normal.Platelet count, bleeding time and blood clot retraction are normal, prothrombin time is normal.F VIII procoagulant activity (F VIII: C) reduces.3. order of severity typing: heavy: F VIII: C<2%, muscle, joint and deep tissue are hemorrhage, joint deformity, false tumor.Medium-sized: F VIII: C2 ~ 5%, joint, muscle and deep tissue can be had hemorrhage, joint deformity, but lighter.Light-duty: F VIII: C6 ~ 25%, joint and hemorrhage of muscle are little, without joint deformity.Subclinical: F VIII: C26 ~ 45%, only at severe trauma or postoperative hemorrhage.
Exclusion standard: von Willebrand's disease patient; Because of the coagulation factor deficiency that other reasons causes.
Therapeutic Method:
Matched group: infusion F VIII preparation during acute hemorrhage, row replacement therapy, to reduce the impaired degree of joint, tissue and organ function, F VIII preparation using dosage is calculated as follows: need F VIII: C total amount=(the horizontal % of the horizontal %-of F VIII: C current plasma F VIII: C that hope reaches) × 0.5 × weight in patients (kg), the half-life of F VIII is 8-12 hour, make F VIII in blood remain on certain level, need every 8-12 h infusion once.Treat 3 days.
Treatment group: on the basis of matched group replacement therapy, takes the tablet of Chinese medicine embodiment 1 of the present invention preparation, each 3, every day 3 times, treats 3 days.
Curative effect judging standard: effective: in 24h, hemorrhage and pain symptom disappears, and the indices such as laboratory examination APTT recover normal, and F VIII: C or F Ⅸ: C returns at least 50%-60%.Effective: hemorrhage and pain symptom disappears or obviously improves, the indices such as laboratory examination APTT are close to normal, and F VIII: C or F Ⅸ: C returns at least 30%-40%.Invalid: indices is without improvement or improve less.
Therapeutic outcome: in table 1.
A table 1 liang group treats two groups of comparitive study (example) after 3 days respectively:
| Group | n | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 66 | 61(92.4％) | 5(7.6％) | 0(0％) | 66(100％) |
| Matched group | 60 | 50(83.3％) | 6(10％) | 4(6.7％) | 56(93.3％) |
As known from Table 1, treatment group adopts Chinese medicine of the present invention, uses, can significantly improve obvious effective rate and the total effective rate of alternative medicine in conjunction with alternative medicine.
Concrete case: high certain, man, 36 years old, suffer from hemophilia since the childhood, there is hemophilia medical history in family, is admitted to hospital sees a doctor because of digestive tract acute hemorrhage, the capable alternative medicine of infusion F VIII preparation, takes tablet prepared by the embodiment of the present invention 1, each 3, every day 3 times simultaneously.Medication 24 hours, bleeding disappears, and hematoma dissipates, and joint walking function recovers normal, and the indices such as laboratory examination APTT recover normal, and F VIII: C or F Ⅸ: C returns at least 50%-60%, effective.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. treat a Chinese medicine for hemophilia A, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Radix Cochleariae officinalis dish, Stephanotis chunii Tsiang, contribution root, Flos Camelliae Japonicae, Flos Caraganae Sinicae, Radix seu Caulis Verntilaginis Leiocarpae, Auricularia polytricha (Mout) Sacc., Herba equiseti ramosissimi, Herba Sedi Aizoon, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu, Radix Platycodonis, wood caragana, Sarcococca ruscifolia Stapf, Herba Rubiae Yunnanensis, Parmelia saxatilis Ach., Rhizoma Gymnadeniae, chlorella and Herba Sambuci Adnatae.
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Cochleariae officinalis dish 30 ~ 40 parts, Stephanotis chunii Tsiang 15 ~ 25 parts, contribution root 20 ~ 35 parts, Flos Camelliae Japonicae 5 ~ 15 parts, Flos Caraganae Sinicae 10 ~ 20 parts, Radix seu Caulis Verntilaginis Leiocarpae 30 ~ 40 parts, Auricularia polytricha (Mout) Sacc. 5 ~ 15 parts, Herba equiseti ramosissimi 10 ~ 25 parts, Herba Sedi Aizoon 10 ~ 20 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 15 ~ 25 parts, Radix Platycodonis 5 ~ 15 parts, wood caragana 10 ~ 20 parts, Sarcococca ruscifolia Stapf 15 ~ 30 parts, Herba Rubiae Yunnanensis 15 ~ 25 parts, Parmelia saxatilis Ach. 30 ~ 40 parts, Rhizoma Gymnadeniae 5 ~ 15 parts, chlorella 15 ~ 25 parts and Herba Sambuci Adnatae 5 ~ 15 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Cochleariae officinalis dish 30 ~ 35 parts, Stephanotis chunii Tsiang 15 ~ 20 parts, contribution root 25 ~ 30 parts, Flos Camelliae Japonicae 5 ~ 10 parts, Flos Caraganae Sinicae 10 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 30 ~ 35 parts, Auricularia polytricha (Mout) Sacc. 5 ~ 10 parts, Herba equiseti ramosissimi 15 ~ 25 parts, Herba Sedi Aizoon 10 ~ 15 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 15 ~ 20 parts, Radix Platycodonis 5 ~ 10 parts, wood caragana 10 ~ 15 parts, Sarcococca ruscifolia Stapf 20 ~ 30 parts, Herba Rubiae Yunnanensis 15 ~ 20 parts, Parmelia saxatilis Ach. 30 ~ 35 parts, Rhizoma Gymnadeniae 5 ~ 10 parts, chlorella 15 ~ 20 parts and Herba Sambuci Adnatae 5 ~ 10 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Cochleariae officinalis dish 34 parts, Stephanotis chunii Tsiang 16 parts, contribution root 29 parts, Flos Camelliae Japonicae 6 parts, Flos Caraganae Sinicae 14 parts, Radix seu Caulis Verntilaginis Leiocarpae 32 parts, Auricularia polytricha (Mout) Sacc. 7 parts, Herba equiseti ramosissimi 18 parts, Herba Sedi Aizoon 13 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 18 parts, Radix Platycodonis 7 parts, wood caragana 11 parts, Sarcococca ruscifolia Stapf 27 parts, Herba Rubiae Yunnanensis 20 parts, Parmelia saxatilis Ach. 32 parts, Rhizoma Gymnadeniae 5 parts, chlorella 16 parts and Herba Sambuci Adnatae 10 parts.
5. the Chinese medicine as described in Claims 1-4, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Radix Cochleariae officinalis dish 30 parts, Stephanotis chunii Tsiang 20 parts, contribution root 26 parts, Flos Camelliae Japonicae 10 parts, Flos Caraganae Sinicae 11 parts, Radix seu Caulis Verntilaginis Leiocarpae 35 parts, Auricularia polytricha (Mout) Sacc. 5 parts, Herba equiseti ramosissimi 24 parts, Herba Sedi Aizoon 10 parts, Angelica niyida Wolff[A. ching-haiensis Shan xe K. T. Fu 16 parts, Radix Platycodonis 10 parts, wood caragana 15 parts, Sarcococca ruscifolia Stapf 23 parts, Herba Rubiae Yunnanensis 15 parts, Parmelia saxatilis Ach. 35 parts, Rhizoma Gymnadeniae 10 parts, chlorella 20 parts and Herba Sambuci Adnatae 6 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
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| CN101757443A (en) * | 2008-10-29 | 2010-06-30 | 天津金世制药有限公司 | Traditional Chinese medicine preparation for treating hemophilia |
| CN102058714A (en) * | 2009-11-17 | 2011-05-18 | 天津天成制药有限公司 | Medicinal composition for treating hemophilia |
| CN103301338A (en) * | 2013-06-14 | 2013-09-18 | 全清清 | Traditional Chinese medicine preparation for treating hemophilia and preparation method thereof |
| CN104306783A (en) * | 2014-11-06 | 2015-01-28 | 徐彧 | Traditional Chinese medicine for treating hemophilia and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757443A (en) * | 2008-10-29 | 2010-06-30 | 天津金世制药有限公司 | Traditional Chinese medicine preparation for treating hemophilia |
| CN102058714A (en) * | 2009-11-17 | 2011-05-18 | 天津天成制药有限公司 | Medicinal composition for treating hemophilia |
| CN103301338A (en) * | 2013-06-14 | 2013-09-18 | 全清清 | Traditional Chinese medicine preparation for treating hemophilia and preparation method thereof |
| CN104306783A (en) * | 2014-11-06 | 2015-01-28 | 徐彧 | Traditional Chinese medicine for treating hemophilia and preparation method thereof |
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Application publication date: 20160217 |