CN106173606A - A kind of Hyperglycemic health care compositions comprising Cortex Mori and Herba Dendrobii - Google Patents

Abstract

The invention discloses a kind of containing Cortex Mori with the health composition of Herba Dendrobii, wherein the percentage by weight of the two can be Cortex Mori and the Herba Dendrobii of 1-99% of 1-99%.Described health composition can also comprise the one in Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Radix Puerariae, Poria, leaf of Cyclocarya paliurus Iljinskaja, Fructus Lycii, Radix Ginseng, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Radix Rhodiolae or its combination in any.Present invention also offers the application in terms of preparation auxiliary treatment hyperglycemia, hypertension or hyperlipidemia health composition of the described health composition.The health composition of the present invention, based on natural drug, has no side effect, and has clear curative effect, synergism and substantially and is prone to the advantages such as masses take.

Description

A kind of Hyperglycemic health care compositions comprising Cortex Mori and Herba Dendrobii

Technical field

The invention belongs to field of health care food, be specifically related to a kind of blood sugar lowering comprising Cortex Mori and Herba Dendrobii and protect It is good for compositions and preparation thereof and purposes.

Background technology

Diabetes (diabetes mellitus, DM) be a kind of common multi-pathogenesis have the interior of genetic predisposition Secretion metabolism disorder disease, along with growth in the living standard, its sickness rate in the trend risen year by year, Becoming the 3rd killer being detrimental to health after cancer, cardiovascular and cerebrovascular disease, diabetes are with hyperglycemia For outstanding feature, and cause series of clinical manifestations.The relevant diabetes that China completes for 1997 are popular Sick investigation problem of learning show, and national onset diabetes rate rises to 3.2%, more from 1% in 1980 Seriously in the old people of more than 60 years old the sickness rate of diabetes more than 11%.Up-to-date in 2012 grinds Studying carefully report display, China diabetes patient occupies the whole world first.

" quenching one's thirst " or " diseases due to endogenous heat of ZANG FU organs " category of the diabetes spp traditional Chinese medical science.Diabetes are broadly divided into by modern medicine Two types a: class is the insulin-dependent (TDDM) of I type, based on inherited genetic factors, mostly occurs In teenager.The another kind of non-insulin-depending type for II type (NIDDM), because of insulin resistant and pancreas Island element secretion relative deficiency or delay, cause blood glucose to raise, and course of disease elder may occur in which the complication of diabetes, It is mainly in and grows up or middle-aged and elderly people.In all diabeticss, 90% is above suffering from type ii diabetes. At present, the treatment of diabetes is except with going back some orally-taken blood sugar reducing medicines of adapted in addition to insulin, such as: sulfonylurea, Metformin class, alpha-glucosidase inhibitor, thiazolidone etc..Although western medicine effect comparison is bright Aobvious, but side effect is big, as easily caused hypoglycemia, lactic acidosis, intestinal discomfort etc..This disease such as can not get Control, it will cause severe chronic complication and then disable lethal.Therefore, the preventing and treating strengthening diabetes is arranged Executing and paid attention to by countries in the world, research prevents and treats the newtype drug of diabetes and health food is domestic and international The advanced subject of association area.Non-medication treatment diabetes have become current medical science, threpsology, food One of focus of scientific research.Although the enterprise that lot of domestic and international is big and scientific research institution, fall over each other research and open Send out hypoglycemic medicine or substitute products, but mostly the most all because of expensive, carrier is undesirable, effect is unstable Or take trouble and not by people's recognition and acceptance.

Additionally, hypertension, hyperlipidemia are also puzzlements people " modern civilization diseases " in recent years, to human body Healthy is very harmful, similar with diabetes to its difficulty prevented and treated.

Hypertension (hypertension) is a kind of with the abnormal cardiovascular disease rising a height of principal character of arterial pressure Sick.The cause of disease is divided into essential hypertension and secondary hypertension.The former accounts for the 90% of hypertension, is referred to as height Blood pressure diseases.Primary disease belongs to the categories such as " dizziness ", " headache " of the traditional Chinese medical science.

Hyperlipemia (hyperlipemia) also known as hyperlipoproteinemia, can behave as hypercholesterolemia, Hypertriglyceridemia or both have concurrently, it is with tremulous pulse medicated porridge sample hardening, diabetes, fatty liver, nephropathy The closest etc. relation.Consequence is especially had day by day to cause people in the morbidity of cardiovascular and cerebrovascular disease Attention.The traditional Chinese medical science thinks that hyperlipemia belongs to the categories such as " turbid resistance ", " phlegm-damp ", " fat ", " damp and hot ".

Hyperglycemia, hypertension, hyperlipidemia (" three high ") cause of disease are complicated, and the current cause of disease is the clearest and the most definite. Although the comparitive study of western medical treatment is certainly at present, but is combined the treatment difficulty of disease and complication thereof relatively Greatly, can cause the side effect that degree is different, patient is often difficult to stand simultaneously, it is impossible to adhere to treatment.In Cure the understanding to above-mentioned disease and preventing and treating, be then to start with from entirety conditioning, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, although do not have Western medicine is quick, but is nursed one's health by entirety, and symptom and index all can be effectively controlled, simultaneously can be effective Protection target organ etc..From clinically, hyperlipidemia, hyperglycemia, hypertensive patients occur, mutually often For cause and effect.Recently, more result of study confirms, in order to reach to prevent and delay complication to occur and send out The purpose of exhibition, it should extremely emphasize the control of many factors, such as in type ii diabetes, except strictly Control, outside blood glucose, blood pressure level, also to take strictly to control blood lipid level, strictly control body weight, The measures such as conventional anticoagulant therapy, to reduce the risk of macroangiopathy further.But so far can be same Time prevention or the Chinese medicine composition for the treatment of " three high " know clearly very few, it is possible to obtain satisfied curative effect and patient The pharmaceutical composition that compliance is high rarely has report especially, and therefore, research and development can prevent simultaneously and treat The safely and effectively medicine of " three high ", is the task of top priority, extremely urgent.

In the last few years, from natural product, the new composition having physiologically active or lead compound are found to open Send out new drug or health food base section has become the focus of global concern and research.Seek blood sugar lowering, blood pressure lowering and fall Its functional factor is also dissected, and then Development and Production goes out blood sugar lowering, blood pressure lowering, fall by fat food resource The Material for Health Food of blood fat food is expected to become the good approach treating these diseases.

Cortex Mori is the dry root bark of moraceae plants Mulberry (Morus alba L.).Another name Cortex Mori, Mulberry Root bark, Cortex Mori, Morus alba skin.Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan.Autumn end falls Leaf excavates root before the secondary spring germinates, and scrapes off yellowish-brown rough bark, longitudinally cuts open, strips root bark, dry. Cortex Mori has eliminating pathogen from the lung for relieving asthma, effect of inducing diuresis to remove edema, can be used for lung-heat cough with asthma, the edema of the face, urine Unfavorable disease such as grade.Modern pharmacology research show Cortex Mori have blood pressure lowering, diuresis, sedation and analgesia, antiinflammatory, Antibacterial and blood sugar lowering isoreactivity.

Herba Dendrobii: (Dendrobium nobile Lindl), has another name called lofty or bottomless palpus, bracketplant, Lin Lan, Dendrobium nobile Lindl China Deng.Stem is upright, and meat shape is plump, the most flat cylinder, long 10～60 centimetres, slightly reaches 1.3 centimetres. Herba Dendrobii containing dendrobine, dendramine, Herba Dendrobii time alkali, dendroxine, dendrine, 6-hydroxydendroxine, Phlegmatic temperament, starch etc..Property slightly sweet flavor micro-salty, cold, return stomach, kidney, lung meridian.There is reinforcing stomach reg fluid, grow Effect of cloudy heat clearing away, loses for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite are retched, deficiency-heat, poor vision after being ill Deng disease.

Although producing at present and there is the medicine of function of polysaccharide and substitute products are of a great variety, but have fall blood concurrently The health product mainly comprising Cortex Mori and Herba Dendrobii of sugar, blood pressure lowering and hypolipemic function are not reported so far.

Summary of the invention

The present inventor, through long-term research and practice, obtains one unexpectedly and has blood sugar lowering, fall blood concurrently Pressure and hypolipemic function, comprise the health composition of Cortex Mori and Herba Dendrobii, thus overcome in prior art The drawbacks described above existed.

It is an object of the present invention to provide a kind of health composition comprising Cortex Mori and Herba Dendrobii, wherein The percentage by weight of the two is Cortex Mori and the Herba Dendrobii of 1-99% of 1-99%.

In one embodiment of the invention, the percentage by weight of Cortex Mori and Herba Dendrobii is 20-80%'s Cortex Mori and the Herba Dendrobii of 20-80%.

Preferably, the percentage by weight of Cortex Mori and Herba Dendrobii can be Cortex Mori and the 30-70% of 30-70% Herba Dendrobii.

It is further preferred that the percentage by weight of Cortex Mori and Herba Dendrobii can be 40-60% Cortex Mori and The Herba Dendrobii of 40-60%.

In another embodiment of the present invention, described health composition can also comprise Rhizoma Polygonati Odorati, mountain One in medicine, Radix Puerariae, Fructus Lycii, Poria, leaf of Cyclocarya paliurus Iljinskaja or its combination in any, described Cortex Mori, Herba Dendrobii can be 1-98%: 1-98% with the percentage by weight of one of above-mentioned Chinese medicine of the five flavours or its combination in any: 1-98%.

Preferably, Cortex Mori, Herba Dendrobii and one of above-mentioned Chinese medicine of the five flavours or the percentage by weight of its combination in any Can be 20-60%: 20-60%: 20-60%.

In yet another embodiment of the present invention, described health composition can also comprise Radix Ophiopogonis, One in the Radix Astragali, Herb Gynostemmae Pentaphylli, Rhizoma Chuanxiong, Folium Apocyni Veneti, Fructus Ligustri Lucidi or its combination in any, the described five tastes One of Chinese medicine or its combination in any percentage by weight shared by health composition of the present invention can be 10-40%, preferably 20-30%, more preferably 25%.

In yet another embodiment of the present invention, above-mentioned health composition also can comprise choosing the most yellow Essence, Thallus Laminariae (Thallus Eckloniae), Fructus Mume, Radix Notoginseng, Fructus Corni, Radix Ginseng, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Radix Rhodiolae, Fructus Schisandrae Chinensis, grey Art, Radix Scrophulariae, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, Aloe, Fructus Schisandrae Chinensis, Radix et Rhizoma Rhei (processed), the Rhizoma Anemarrhenae, Fructus Tribuli, Folium Ginkgo, Fructus Momordicae charantiae, Radix Et Rhizoma Fagopyri Tatarici, Fructus Cucurbitae moschatae, Rhizoma amorphophalli, Herba Apii graveolentis, Stigma Maydis, Tremella, Hericium erinaceus (Bull. Ex Fr.) Pers. and Bulbus Allii One or more of in the group formed.

In the present invention, described health composition can be carried out by the preparation method of any routine in this area Preparation.

Further object is that providing described health composition treats high blood in preparation auxiliary Application in terms of sugar, hypertension or hyperlipidemia health composition.

A further object of the present invention there are provided a kind of pharmaceutical preparation containing described health composition.

The health composition of the present invention can be prepared as any with pharmaceutically acceptable adjuvant as required Suitably oral formulations is for blood sugar lowering, blood pressure lowering or the treatment of blood fat reducing.

In yet other embodiments, described oral formulations can be tablet, capsule, The dosage forms such as granule, powder, effervescent, bagged steeping drug.

In yet other embodiments, described pharmaceutically acceptable adjuvant such as can select From pregelatinized Starch, beta-schardinger dextrin-, carbomer, microcrystalline Cellulose, hydroxypropyl methyl cellulose, low take For hydroxypropyl cellulose, Polyethylene Glycol (PEG), sodium carboxymethyl cellulose, methylcellulose, ethyl Cellulose, mannitol, cross-linking sodium carboxymethyl cellulose, lactose, polyvinylpyrrolidone (PVP), One in magnesium stearate, Pulvis Talci, micropowder silica gel, aspartame, sodium bicarbonate, sodium carbonate or more Multiple.

Effect activity of each primary raw material medicine in the present invention

Cortex Mori: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema, can be used for lung-heat cough with asthma, the edema of the face, dysuria Deng disease.There is blood pressure lowering, diuresis, sedation and analgesia, antiinflammatory, antibacterial and blood sugar lowering isoreactivity.

Herba Dendrobii: property slightly sweet flavor is micro-salty, cold, return stomach, kidney, lung meridian；There is reinforcing stomach reg fluid, nourishing YIN and clearing away heat Effect, lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite are retched, deficiency-heat, poor vision after being ill.

Rhizoma Polygonati Odorati: yin nourishing, moisturize, heat clearing away, promote the production of body fluid, cough-relieving, can be used as tonic, cure mainly calentura wound The disease such as the moon, deficiency-heat cough caused by dryness, heart disease, diabetes, tuberculosis.

Pericarpium Citri Reticulatae: bitter in the mouth, pungent, warm in nature；Return lung, spleen channel；There is regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm, For diseases such as distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.

Rhizoma Dioscoreae: sweet in the mouth, property are flat, return spleen, lung, kidney channel；Having spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating Effect of arresting seminal emission, be used for treating insufficiency of the spleen, chronic diarrhea, the deficiency of the lung, suffer from a deficiency of the kidney, the disease such as leukorrhagia, frequent micturition.

Radix Puerariae: sweet in the mouth, pungent, cool in nature.Attach to the lung and stomach meridians.Have expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, Effect of yang invigorating antidiarrheal, the deficiency of YIN thirsty for exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura disappears Yearningly, the disease such as diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.

Fructus Lycii: sweet is flat.Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For syndrome of yin deficiency of liver and kidney. The sweet flat matter of this product is moistened, and flat invigorating the liver and kidney has strengthening by means of tonics effect, all cards of all hepatic and renal YIN deficiency all can apply.

Leaf of Cyclocarya paliurus Iljinskaja: mildly bitter flavor, pungent, property is put down.Have invigorating the spleen for eliminating dampness, Clearing heat and removing obstruction of fu-organs, depressed liver-energy dispersing and QI regulating, The effect of enriching yin and nourishing kidney, to because dysfunction of the spleen, expectorant are turbid, addiction delicious food savoury, lazy dynamic, abdominal distention food stagnation, The liver silt stagnation of QI and the obesity that causes, have good improvement.

Radix Ophiopogonis: sweet, micro-hardship, it is slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.With In dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine Constipation.

The Radix Astragali: sweet, tepor.Gui Jing: return lung, spleen, liver, kidney channel.Have invigorating QI to consolidate the body surface resistance, diuretic moves back The effects such as swollen, expelling pus and toxin by strengthening QI, granulation promoting.

Herb Gynostemmae Pentaphylli: bitter in the mouth；Micro-sweet；Cool in nature.Return lung；Spleen；Kidney channel.Replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, Heat-clearing and toxic substances removing.Cure mainly: body void is weak；Nephrasthenia emission；Leukopenia；Hyperlipemia；Viral Hepatitis；Chronic gastroenteritis；Chronic tracheitis.

Rhizoma Chuanxiong: pungent, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled Headache rotation is dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores. For menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia.

Folium Apocyni Veneti: suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.For dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria； Hypertension, neurasthenia, nephritis edema.

Fructus Ligustri Lucidi: sweet, bitter, cold.Return liver, kidney channel.Liver and kidney tonifying, improving eyesight, clearind deficient heat.Cure mainly head Dizzy dizzy, early whitening of beard and hair, blurring of vision, fever due to yin deficiency.

Technical scheme has the advantage that

Compared with prior art, the present inventor has carried out a large amount of screening in numerous Chinese medicines and food, thus Obtain a kind of health composition comprising the Chinese medicine such as Cortex Mori and Herba Dendrobii, described health composition unexpectedly Have the excellent effect of blood sugar lowering, blood pressure lowering and blood fat reducing concurrently, and in blood sugar lowering, blood pressure lowering and blood fat reducing merit Aspect can create obvious synergism.Have clear curative effect, easy to use, synergism substantially and It is prone to the advantages such as masses take.

The health composition of the present invention, based on natural drug, has no side effect, and makes patient at normal drink In the case of food, consciously safeguard glucostasis, it is thus achieved that the non-drug therapy effect of diabetes.

Detailed description of the invention

To further describe the present invention below in detail.It is pointed out that following description is only to this The illustration of the technical scheme that invention is claimed, the not any restriction to these technical schemes.This The content that the protection domain of invention is recorded with appended claims is as the criterion.

Embodiment 1

Formula forms: Cortex Mori 1.0kg, Herba Dendrobii 9.0kg.

Preparation method:

2.1 accurately weigh each taste Chinese medicine according to above-mentioned formula, clean by clean water, boil extraction 2 times； For the first time add 12 times amount water, extracts 2 hours, add 10 times amount water for the second time, extract 1 hour, 100 Mesh filters；

2.2 united extraction liquid, filter, and filtrate is concentrated into 60 DEG C of heat and surveys relative density 1.05-1.08, standby；

2.3 filtrates add formula proportion amount cycloheptaamylose, is heated to 85 DEG C, after being uniformly mixed, Constant temperature 30 minutes,

Filtrate is added in spray dryer by 2.4, first preheating tower temperature, treats that inlet temperature reaches 210 DEG C ± 10 Charging is started after DEG C；The regulation of flow to be carried out, wind speed after charging, leaving air temp is controlled 95 DEG C ± 5 DEG C, obtain extract powder, seal powder with double-deck clean plastic bag packaging；

2.4 by formula proportion amount weigh microcrystalline Cellulose, calcium hydrogen phosphate, silicon dioxide, magnesium stearate mix Close 3-5 minute to uniformly, obtain mixed material；

Mixed material is carried out soft material processed with 80% edible ethanol by 2.5, crosses 14 mesh, obtains wet granular；Wet Grain is dried to moisture≤5.0%.Dry granule is crossed 16 mesh granulate, obtains dry granule；

Total mixture material is filled by every 0.3g by 2.6 with No. 1 capsule.

Embodiment 2

1, formula composition: Cortex Mori 2.0kg, Herba Dendrobii 7.0kg, Fructus Lycii 1.0kg.

2, preparation method: with embodiment 1.

Embodiment 3

1, formula composition: Cortex Mori 3.5kg, Herba Dendrobii 2.0kg, leaf of Cyclocarya paliurus Iljinskaja 3.5kg, Pericarpium Citri Reticulatae 1.0kg.

2, preparation method: with embodiment 1.

Embodiment 4

1, formula composition: Cortex Mori 6.0kg, Herba Dendrobii 2.0kg, Radix Ophiopogonis 0.5kg, Rhizoma Chuanxiong 0.5kg, Radix Astragali 0.5kg, Herb Gynostemmae Pentaphylli 0.5kg.

2, preparation method: with embodiment 1.

Embodiment 5

1, formula composition: Cortex Mori 8.0kg, Herba Dendrobii 0.5kg, Rhizoma Polygonati Odorati 0.5kg, Rhizoma Dioscoreae 0.5kg, Pueraria lobota Root 0.5kg.

2, preparation method: with embodiment 1.

Embodiment 6

1, formula composition: Cortex Mori 1.0kg, Herba Dendrobii 1.0kg, Fructus Corni 1.0kg, Hericium erinaceus (Bull. Ex Fr.) Pers. 1.0kg, Thallus Laminariae (Thallus Eckloniae) 1.0kg, Rhizoma Polygonati 1.0kg, Rhizoma Atractylodis 1.0kg, Radix Paeoniae Alba 1.0kg, Fructus Mume 1.0kg, Tremella 1.0kg.

2, preparation method: with embodiment 1.

Comparative example 1

Choose the sample as a comparison case 1 that Cortex Mori 10kg is prepared by the preparation method in embodiment 1.

Comparative example 2

Choose the sample as a comparison case 2 that Herba Dendrobii 10kg is prepared by the preparation method in embodiment 1.

Comparative example 3

Choose the sample as a comparison case 3 that Pericarpium Citri Reticulatae 10kg is prepared by the preparation method in embodiment 1.

The scope of the present invention is not limited to above example, and each component in above-described embodiment is all selected from Commercial goods, by the preparation process that this area is conventional, can make multiple dosage form described on pharmaceutics, Such as capsule, granule, powder, tablet, oral liquid, teabag etc..

Experimental example 1: blood sugar lowering is tested

1, material and method

1.1 samples and reagent: sample prepared by embodiment 1-6 and comparative example 1-3, be respectively designated as S1, S2, S3, S4, S5, S6, and D1, D2, D3；Streptozotocin, SIGMA Products, Specification: 1g/ props up, lot number: SLBJ7785V；The sodium chloride injection (normal saline) of 0.9%, rule Lattice: 250ml/ bottle, Kelun Pharm Ind Co., Ltd., Sichuan, lot number: C13102005-1；High lipid food Formula (79% basal diet+1% cholesterol+15% fresh yolk+5% Adeps Sus domestica), picric acid etc..

1.2 instrument W-80A eddy mixers, Instrument Factory of Shanghai Medical Univ.'s product；Electronic balance, mettler Toledo, made by mettler-toledo group, model: pl303；LDZ5-2 centrifuge, north Jing Yiyonglixinjichang；Johnson & Johnson surely person of outstanding talent's blood glucose meter (Johnson & Johnson (Chinese) medical device company limited)； BECKMAN Synchron CX5 fully automatic blood biochemistry analyzer (U.S.)；Microplate reader, bio-rad (U.S.), model: iMark；Other: platform balance, fixing cage etc..

1.3 laboratory animal SPF level SD rats, body weight 160～180g, male, big by south medical courses in general Experimental Animal Center provides, the quality certification number: SCXK (Guangdong) 2011-0015.Animal is in SPF level barrier Level Animal House is raised, and animal use credit number is: SYXK (Guangdong) 2012-0081.

1.4 dosage arrange adult's plan dosage and are 3.0g/60kg BW days, and human body 10 times amount is rat Dosage, dosage is with crude drug gauge.

1.5 statistical analysis use SPSS17.0 statistical software to carry out data process, and parameter mean ± Standard deviationRepresenting, comparing between group and use ANOVA variance analysis test, p ＜ 0.05 is for there being statistics Learn difference.

2. method and result

2.1 method

2.1.1 rat feed normal diet: Semen Maydis powder 80%, flour 15%, analysis for soybean powder 5%；High fat Feedstuff: 79% basal diet+1% cholesterol+15% fresh yolk+5% Adeps Sus domestica.

2.1.2 modeling: take 160-180gSPF level SD rat 110, male, body weight 160～180g, Adaptability takes 10 after feeding one week and is only used as Normal group, feeds with chow diet, and other respectively organizes elder generation Feed 1 month with high lipid food, after selective examination blood lipids index is significantly raised, lumbar injection STZ 35mg/kg (STZ is before use by the citric acid/sodium citrate buffering of 0.1mmol/LpH=4.5 for induced Diabetic model Liquid is made into the solution of 6mg/mL, and is finished in 60min).7d after injection, docking gathers sky Abdomen venous blood, measures blood glucose with blood glucose meter, is considered as being modeled as more than or equal to 16.7mmol/L by blood glucose value Merit.After model stability, according to blood-fat and blood sugar height packet, it is orally administered to test medicine and control drug, Observe indices.

2.1.3 it is grouped and is administered: preferable 100 the modeling success animals of state of choosing are according to blood glucose value and body Weight average is even is divided into 10 groups: often group 10, i.e. type ii diabetes model control group (giving distilled water), S1 group, S2 group, S3 group, S4 group, S5 group, S6 group, D1 group, D2 group and D3 group.Normally The SD rat of not modeling 10 is Normal group (giving distilled water).Each group is administered orally by corresponding dosage It is administered, is administered once daily, dosage period: 4 weeks (4W).

2.2 testing index

2.2.1 use blood glucose meter respectively measure administration before and be administered after 4W blood glucose value.

2.2.2 carbohydrate tolerance test: terminate a few days ago to detect in experiment；Carbohydrate tolerance detects: animal fasting About 6 hours, each group gave variable concentrations given the test agent, oral administration of glucose 2.0g/kg after 15-20 minute, Measuring to the blood glucose value of after glucose 0,0.5,2 hours, observing and nursing matched group is given with given the test agent group The change of each time point Area under the curve of blood glucose after glucose.Area under the curve of blood glucose=1/2 × (0 hour blood Sugar value+0.5 hours blood glucose value) × 0.5+1/2 × (2 hours blood glucose value+0.5 hours blood glucose value) × 1.5= 0.25 × (0 hours blood glucose value+4 × 0.5 hours blood glucose value+3 × 2 hours blood glucose value).

2.3 result

2.3.1 the impact on type ii diabetes rat blood sugar

From table 1, comparing with Normal group, it is notable that the front Glycemia Decline of administration respectively organizes rat blood sugar Raise, show diabetes model modeling success.After being administered 4w, S1-S6 group blood glucose all has decline.

The impact on type ii diabetes rat blood sugar of table 1. sample

Group	n	Blood glucose (mmol/L) before being administered	It is administered 4W blood glucose (mmol/L)
				Normal group	10	5.37±1.03	5.40±1.14
Model control group	10	19.33±4.19##	22.58±3.62##
				S1 group	10	19.25±4.36	16.89±3.75*
S2 group	10	19.37±4.01	16.72±3.68*
				S3 group	10	19.41±3.89	15.22±3.19**
S4 group	10	19.25±4.25	17.13±3.10*
				S5 group	10	19.24±4.10	16.86±3.72*

S6 group	10	19.36±3.98	16.29±4.26*
				D1 group	10	19.22±3.79	19.29±4.55
D2 group	10	19.42±4.36	19.15±5.06
				D3 group	10	19.29±4.15	19.42±5.71

Note: compare with Normal group:^##P ＜ 0.01；Compare with model group:^*P ＜ 0.05,^*P ＜ 0.01

2.3.2 to type ii diabetes rat carbohydrate tolerance test result

From table 2, comparing with model control group, the Area under the curve of blood glucose of S1-S6 group all has decline.

Table 2. sample is to type ii diabetes rat carbohydrate tolerance test result

Group	n	Area under the curve of blood glucose
			Normal group	10	14.87±3.48
Model control group	10	38.51±5.69##
			S1 group	10	26.17±5.81*
S2 group	10	26.79±5.90*
			S3 group	10	25.02±5.18**
S4 group	10	27.33±6.07*
			S5 group	10	26.68±6.35*

S6 group	10	26.47±6.31*
			D1 group	10	34.82±6.73
D2 group	10	35.91±6.94
			D3 group	10	35.86±6.52

Note: compare with Normal group:^#P ＜ 0.05,^##P ＜ 0.01；Compare with model control group: p is equal More than 0.05.

3. conclusion: S1-S6 has an obvious hypoglycemic activity to diabetic model rats, and S1-S6 Compositions creates significant synergy in terms of blood sugar lowering.

Experimental example 2: lipid-lowering test

1, material and method

1.1 medicines and reagent: sample prepared by embodiment 1-6 and comparative example 1-3, be respectively designated as S1, S2, S3, S4, S5, S6, and D1, D2, D3；The sodium chloride injection (normal saline) of 0.9%, Specification: 250ml/ bottle, Kelun Pharm Ind Co., Ltd., Sichuan, lot number: C13102005-1；High fat is raised Material formula (79% basal diet+1% cholesterol+15% fresh yolk+5% Adeps Sus domestica), distilled water, picric acid, Deng.

1.2 instrument W-80A eddy mixers, Instrument Factory of Shanghai Medical Univ.'s product；Electronic balance, mettler Toledo, made by mettler-toledo group, model: pl303；LDZ5-2 centrifuge, north Jing Yiyonglixinjichang；BECKMAN Synchron CX5 fully automatic blood biochemistry analyzer is (beautiful State)；Other: platform balance, fixing cage etc..

1.3 laboratory animal SPF level SD rats, body weight 160～180g, male, big by south medical courses in general Experimental Animal Center provides, the quality certification number: SCXK (Guangdong) 2011-0015.Animal is in SPF level barrier Level Animal House is raised, and animal use credit number is: SYXK (Guangdong) 2012-0081.

1.4 dosage arrange adult's plan dosage and are 3.0g/60kg BW days, and human body 10 times amount is rat Dosage, dosage is with crude drug gauge.

1.5 statistical analysis use SPSS17.0 statistical software to carry out data process, and parameter mean ± Standard deviation (x ± s) represents, comparing between group and use ANOVA variance analysis test, p ＜ 0.05 is for there being statistics Learn difference.

2. method and result

2.1 packets take SPF level SD rat 110 with method, male, and body weight 160～180g is suitable Answering property takes 10 after feeding one week and is only used as Normal group, feeds with chow diet；Residue gives high fat Forage feed.Continuous nursing 4 weeks (determining that modeling is the most successful by timing blood drawing detection four items of blood lipid tests) After, preferable 100 the modeling success animals of state of choosing uniformly are divided into 10 according to blood fat numerical value and body weight Group: often group 10, i.e. hyperlipemia model matched group (giving distilled water), S1 group, S2 group, S3 Group, S4 group, S5 group, S6 group, D1 group, D2 group and D3 group.

High lipid food is started to be administered and continue (just feeding high lipid food by above packet situation after feeding 4 weeks Often matched group feeds normal diet), every day 1 time, successive administration 4w.After last is administered, fasting overnight, After next day weighs in, chloral hydrate anesthesia, put to death after postcava blood sampling.Take supernatant after Li Xin to survey Biochemical indicator in serum.

2.2 Testing index:

(1) general status is observed, and records body weight weekly.

(2) each group rat blood serum lipid index: orbital venous plexus takes blood every two weeks, separation Virus monitory: T-CHOL (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density lipoprotein, LDL (LDL-C)。

2.3 result

2.3.1 on the impact of TC, TG, HDL-C, LDL-C in serum

Iipid data in rat blood serum after table 3. modeling success even group-division

Note: compare with Normal group:^#P ＜ 0.05,^##P ＜ 0.01；Compare with model control group: p is equal More than 0.05.

Table 4. is each after being administered 4W organizes Iipid data in rat blood serum

Note: compare with Normal group:^#P ＜ 0.05,^##P ＜ 0.01；Compare with model group:^*P ＜ 0.05,^*P ＜ 0.01

From table 3, compare with Normal group, after model control group feeds high lipid food 4W, rat Serum TC, LDL-C significantly raise (p ＜ 0.01), TG significantly raised (p ＜ 0.05), show hyperlipemia Disease rat model modeling success.4 groups uniformly it are divided into according to blood lipid level.

From table 4, after being administered 4W, comparing with model control group, S1-S6 group can reduce in serum TC, TG, LDL-C level (p ＜ 0.05 or p ＜ 0.01).

3. conclusion: S1-S6 has an obvious effect for reducing blood fat to Hyperlipemia model rat, and S1-S6 Compositions creates significant synergy in terms of blood fat reducing.

Experimental example 3: blood pressure lowering is tested

1, material and method

1.1 medicines and reagent: sample prepared by embodiment 1-6 and comparative example 1-3, be respectively designated as S1, S2, S3, S4, S5, S6, and D1, D2, D3；The sodium chloride injection (normal saline) of 0.9%, Specification: 250ml/ bottle, Kelun Pharm Ind Co., Ltd., Sichuan, lot number: C13102005-1；Distilled water, Picric acid, etc..

1.2 instrument DKB-501A type super constant temperature water tanks, reliable test Instrument Ltd. for Shanghai is gloomy Product；Constant Temp. Oven, for Changsha medical apparatus and instruments factory product；Powlab/4sp ML125 type without Wound pressure measuring system (ML125/R NIBP, MLT1199 BPTrans-ducer/Cable Kit), Australia is big Leah Ai De Instrument Ltd. product；MP120-1 electronic balance, for Shanghai Second Balance Factory Product.

1.3 laboratory animal SPF level SHR rats, body weight 190～230g, male, logical by Beijing dimension Li Hua laboratory animal Technology Co., Ltd. provides, the quality certification number: SCXK (capital) 2012-0001.Animal in SPF level barrier level Animal House is raised, and animal use credit number is: SYXK (Guangdong) 2012-0081, SPF level WISTAR male rat, Beijing Vital River Experimental Animals Technology Co., Ltd. provides, real Testing animal productiong credit number is: SCXK (capital) 2012-0001.

1.4 dosage arrange adult's plan dosage and are 3.0g/60kg BW days, and human body 10 times amount is rat Dosage, dosage is with crude drug gauge.

1.5 statistical analysis use SPSS17.0 statistical software to carry out data process, and parameter mean ± Standard deviation (x ± s) represents, comparing between group and use ANOVA variance analysis test, p ＜ 0.05 is for there being statistics Learn difference.

2. method and result

10 groups are divided at random, often group 10 by male for 9-10 week old spontaneous hypertensive rat (SHR), I.e. hypertension model matched group (giving distilled water), S1 group, S2 group, S3 group, S4 group, S5 group, S6 group, D1 group, D2 group and D3 group.Separately take normal WISTAR rat 10 for Normal group (giving distilled water).Each treated animal gavage respectively gives various dose drug, every day 1 time, is administered 4 altogether Week.Within 4 weeks, rat tail artery blood is detected with noinvasive arteria caudalis pressure measuring system before being administered and after being administered Pressure value (shrinks pressure, SAP, mmHg).

Noinvasive tail sleeve method (NIBP): rat is put into rat fixator, exposes rat-tail.Take with infrared Warmer, temperature is set to 38 DEG C, and after irradiating heating rat-tail about 10min, rat-tail deliquescing, rat-tail is moved Arteries and veins is fully expanded.Be passed through pressurizeing tail sleeve and being fixed on the root of rat-tail, make rat tail artery with PowerlabML125/R noinvasive arteria caudalis blood pressure determination is analyzed the pulse transducer of system and is in close contact, with Time observation system pulse wave, can start when stable pulse wave occurs to measure blood pressure.Treat that animal is pacified After quiet, select 90～420BPM (rat pressurization shelves) to tail sleeve inflating pressure, it is seen that pulse wave gradually subtracts Little to disappearing, then tail sleeve starts venting, and Mus set pressure reduces, and when pressure is equal to when shrinking pressure, starts Pulse wave occur, the pressure value of this point is rat-tail and shrinks pressure.Repeated measure 3 times, averages.Meter Calculating voltage drop value (drop-out value of blood pressure), before after administration, SAP deducts administration, SAP obtains.The results are shown in Table 5:

The impact to SHR rat blood pressure (SAP, mmHg) of table 5 sample

Note: compare with Normal group: # is P ＜ 0.01；Compare with model control group: * is P ＜ 0.05.

Result shows, compares with Normal group, and model control group rat blood pressure significantly raises, it is seen that from The success of Essential hypertension rat model.With model control group, S1-S6 group can significantly reduce at administration 4W The blood pressure (P ＜ 0.05) of SHR rat.

3. conclusion: S1-S6 sample has significant hypotensive activity, and the compositions of S1-S6 is at blood pressure lowering Aspect creates significant synergy.

Present invention merely illustrates some claimed specific embodiments, one of them or Technical characteristic described in more technical schemes can be with arbitrary one or more technical scheme phases Combination, these are combined and the technical scheme that obtains also in the application protection domain, just as these are through group As the technical scheme closed and obtain specifically is recorded in the disclosure of invention.

Claims (16)

1. a health composition, it comprises Cortex Mori and Herba Dendrobii.

Health composition the most according to claim 1, the wherein weight hundred of Cortex Mori and Herba Dendrobii Proportion by subtraction is 1-99%: 1-99%.

Health composition the most according to claim 1 and 2, wherein Cortex Mori and the weight of Herba Dendrobii Amount percentage ratio is 20-80%: 20-80%.

4. according to the health composition described in any one of claim 1-3, wherein Cortex Mori and Herba Dendrobii Percentage by weight is 30-70%: 30-70%.

5. according to the health composition described in any one of claim 1-4, wherein Cortex Mori and Herba Dendrobii Percentage by weight is 40-60%: 40-60%.

6. according to the health composition described in any one of claim 1-5, wherein said health composition In also comprise the one in Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Radix Puerariae, Poria, leaf of Cyclocarya paliurus Iljinskaja or its combination in any, institute State Cortex Mori, Herba Dendrobii and the one in Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Radix Puerariae, Poria, leaf of Cyclocarya paliurus Iljinskaja or it is any The percentage by weight of combination is 1-98%: 1-98%: 1-98%.

Health composition the most according to claim 6, wherein Cortex Mori, Herba Dendrobii and Rhizoma Polygonati Odorati, The percentage by weight of a kind of or its combination in any in Rhizoma Dioscoreae, Radix Puerariae, Poria, leaf of Cyclocarya paliurus Iljinskaja is 10-80%: 10-80%: 10-80%.

8., according to the health composition described in claim 6 or 7, wherein Cortex Mori, Herba Dendrobii are with beautiful The percentage by weight of a kind of or its combination in any in bamboo, Rhizoma Dioscoreae, Radix Puerariae, Poria, leaf of Cyclocarya paliurus Iljinskaja is 20-60%: 20-60%: 20-60%.

9. according to the health composition described in any one of claim 1-8, wherein said health composition In also comprise the one in Fructus Lycii, Radix Ginseng, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Radix Rhodiolae Chinese medicine of the five flavours or it is any Combination, the weight that one of described Chinese medicine of the five flavours or its combination in any are shared in health composition of the present invention Percentage ratio is 10-40%.

Health composition the most according to claim 9, one of wherein said Chinese medicine of the five flavours or its Combination in any accounts for 20-30% in health composition of the present invention.

11. according to the health composition described in claim 9 or 10, wherein said Chinese medicine of the five flavours it One or its combination in any in health composition of the present invention, account for 25%.

12. according to the health composition described in any one of claim 1-11, it is characterised in that described In compositions also comprise choosing free Rhizoma Polygonati, Thallus Laminariae (Thallus Eckloniae), Fructus Mume, Radix Notoginseng, Fructus Ligustri Lucidi, Fructus Corni, Rhizoma Chuanxiong, Rhizoma Atractylodis, Radix Scrophulariae, Radix Rehmanniae, the Radix Paeoniae Alba, Radix Panacis Quinquefolii, Aloe, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Radix et Rhizoma Rhei (processed), The Rhizoma Anemarrhenae, Fructus Tribuli, Folium Ginkgo, the Radix Astragali, Herb Gynostemmae Pentaphylli, Fructus Momordicae charantiae, Radix Et Rhizoma Fagopyri Tatarici, Fructus Cucurbitae moschatae, Rhizoma amorphophalli, Herba Apii graveolentis, One or more of in the group that Stigma Maydis, Tremella, Hericium erinaceus (Bull. Ex Fr.) Pers. and Bulbus Allii are formed.

Health composition described in 13. any one of claim 1-12 is at preparation treatment hyperglycemia, high blood Application in pressure or hyperlipidemia health composition.

The pharmaceutical preparation of 14. 1 kinds of health compositions comprised described in any one of claim 1-12, its Middle described health composition and pharmaceutically acceptable adjuvant are prepared as oral formulations.

15. pharmaceutical preparatioies according to claim 14, wherein said oral formulations be tablet, Capsule, granule, powder, effervescent or bagged steeping drug.

16. according to the pharmaceutical preparation described in claims 14 or 15, wherein said pharmaceutically acceptable Adjuvant fine selected from pregelatinized Starch, beta-schardinger dextrin-, carbomer, microcrystalline Cellulose, hydroxypropyl methyl Dimension element, low-substituted hydroxypropyl cellulose, Polyethylene Glycol (PEG), sodium carboxymethyl cellulose, methyl Cellulose, ethyl cellulose, mannitol, cross-linking sodium carboxymethyl cellulose, lactose, polyvinyl pyrrole Alkanone (PVP), magnesium stearate, Pulvis Talci, micropowder silica gel, aspartame, sodium bicarbonate, carbon Acid sodium in one or more of.