CN106729190B - A granule containing Chinese medicinal effective components for invigorating spleen, invigorating qi and eliminating dampness, and its preparation method - Google Patents

A granule containing Chinese medicinal effective components for invigorating spleen, invigorating qi and eliminating dampness, and its preparation method Download PDF

Info

Publication number
CN106729190B
CN106729190B CN201710122084.XA CN201710122084A CN106729190B CN 106729190 B CN106729190 B CN 106729190B CN 201710122084 A CN201710122084 A CN 201710122084A CN 106729190 B CN106729190 B CN 106729190B
Authority
CN
China
Prior art keywords
extracting
water
extract
time
placing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201710122084.XA
Other languages
Chinese (zh)
Other versions
CN106729190A (en
Inventor
孙淑萍
李胜利
张晗
郭派派
李悦
姚文静
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wannan Medical College
Original Assignee
Wannan Medical College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wannan Medical College filed Critical Wannan Medical College
Priority to CN201710122084.XA priority Critical patent/CN106729190B/en
Publication of CN106729190A publication Critical patent/CN106729190A/en
Application granted granted Critical
Publication of CN106729190B publication Critical patent/CN106729190B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides granules containing traditional Chinese medicine active ingredients for tonifying spleen, benefiting qi and eliminating dampness and a preparation method thereof, wherein the granules contain lotus leaf extract, Chinese yam extract, poria cocos extract, burdock extract, eucommia bark extract, hawthorn extract, coix seed extract, red bean extract, red date extract, roasted malt extract, soluble starch, sucrose, dextrin, distilled water and 75% ethanol. Compared with the prior art, the traditional Chinese medicine composition adopts various traditional Chinese medicine active ingredients, and can tonify qi, invigorate spleen, eliminate dampness, reduce phlegm and condition phlegm-damp type physique; eliminating local edema, improving symptoms caused by spleen deficiency, such as hyperhidrosis, excessive phlegm, asthenia, lethargy, listlessness, etc., invigorating spleen, and removing water dampness.

Description

A granule containing Chinese medicinal effective components for invigorating spleen, invigorating qi and eliminating dampness, and its preparation method
Technical Field
The invention relates to the field of medicines, and in particular relates to granules containing traditional Chinese medicine active ingredients and having the effects of tonifying spleen, benefiting qi and eliminating dampness and a preparation method thereof.
Background
At present, the rhythm of social life suddenly changes, office workers are tired and rushed for the life, and the bodies of the office workers are gradually suffered from a plurality of diseases, insufficient sleep, moist environment and the like under high-intensity working pressure; the symptoms of waist soreness, headache, rheumatism and other diseases caused by irregular living habits are increased. Not only these diseases, but also serious people cause the decline of immunity of the organism, and more serious diseases will also come on, so the series of problems are not easy to solve.
Meanwhile, the middle-aged and the elderly people in modern times are mostly in the form of phlegm-dampness, and are mostly in the form of joint edema, expectoration in the mouth and throat and other common phlegm-dampness symptoms; meanwhile, the middle-aged and old people can not live in a peaceful life because of symptoms such as hyperhidrosis, excessive phlegm, tiredness, lassitude and the like caused by spleen deficiency, and the life quality of the middle-aged and old people is reduced, so that the old people can not live in a peaceful life and the past life is greatly interfered for a long time. The generation of the medicine is related to the living environment and the autoimmunity, and no medicine for thoroughly improving the current situation exists at present. The traditional Chinese medicine has increasingly shown unique advantages in tonifying spleen, benefiting qi, eliminating dampness and reducing phlegm, and has great potential.
The research and development of the spleen-tonifying and qi-tonifying medicine can bring great guarantee to the life quality of people. People no longer take medicines only for treating diseases, and the initial purpose of research and development of medicines for tonifying spleen, replenishing qi and eliminating dampness is to improve the immunity without bringing more side effects.
Disclosure of Invention
The invention aims to provide granules containing effective components of traditional Chinese medicines for tonifying spleen, benefiting qi and eliminating dampness, which contain various traditional Chinese medicine extracts, have the effects of tonifying spleen, benefiting qi and eliminating dampness and have no side effect.
The invention also provides a preparation method of the granules containing the effective components of the traditional Chinese medicines for tonifying spleen, benefiting qi and eliminating dampness.
The invention provides a granule containing effective components of traditional Chinese medicines for invigorating spleen, replenishing qi and eliminating dampness, which comprises the following raw materials in parts by weight:
Figure BDA0001237347970000021
the hawthorn extract is prepared by the following method:
weighing an appropriate amount of hawthorn, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 15-20 times of water for 1 time, extracting for 1.0-2.0h, adding 12-15 times of water for 2 times, extracting for 0.5-1.5h, adding 8-12 times of water for 3 times, extracting for 0.5-1.5h, filtering for each time, combining filtrates, concentrating to viscous state, placing on a water bath kettle at 80-100 deg.C to steam to a non-flowing state, placing in an oven at 40-80 deg.C to dry, pulverizing, sieving with a 40-80 mesh sieve to obtain the hawthorn extract, and placing in a dryer for later use.
The red date extract is prepared by the following method:
weighing appropriate amount of fructus Jujubae, cutting pulp, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 12-15 times of water for 1 time, extracting for 1.0-2.0h, adding 10-12 times of water for 2 times, extracting for 0.5-1.5h, adding 8-10 times of water for 3 times, extracting for 0.5-1.5h, filtering each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying at 40-80 deg.C, pulverizing, sieving with 40-80 mesh sieve to obtain fructus Jujubae extract, and drying in dryer for use.
The lotus leaf extract is prepared by the following method:
weighing appropriate amount of folium Nelumbinis, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 20-25 times of water for 1 time, extracting for 1.0-2.0h, adding 15-20 times of water for 2 times, extracting for 0.5-1.5h, adding 10-15 times of water for 3 times, extracting for 0.5-1.5h, filtering for each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying at 40-80 deg.C, pulverizing, sieving with 40-80 mesh sieve to obtain folium Nelumbinis extract, and drying in a dryer for use.
The red bean extract is prepared by the following method:
weighing an appropriate amount of red beans, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 12-15 times of water for 1 time, extracting for 1.0-2.0h, adding 10-12 times of water for 2 times, extracting for 0.5-1.5h, adding 8-10 times of water for 3 times, filtering each time, extracting for 0.5-1.5h, combining filtrates, concentrating to viscous state, steaming in a water bath kettle at 80-100 deg.C to non-flowing state, drying in an oven at 40-80 deg.C, pulverizing, sieving with a 40-80 mesh sieve to obtain red bean extract, and drying in a dryer for later use.
The coix seed extract is prepared by the following steps:
weighing an appropriate amount of coix seeds, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 15-20 times of water for 1 time, extracting for 1.0-2.0h, adding 12-15 times of water for 2 times, extracting for 0.5-1.5h, adding 8-12 times of water for 3 times, extracting for 0.5-1.0h, filtering for each time, combining filtrates, concentrating to viscous state, placing on a water bath kettle at 80-100 deg.C to steam to a non-flowing state, placing in an oven at 40-80 deg.C to dry, pulverizing, sieving with a 40-80 mesh sieve to obtain coix seed extract, and placing in a dryer for later use.
The burdock extract is prepared by the following method:
weighing appropriate amount of burdock coarse powder, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 14-20 times of water for 1 time, extracting for 1.0-2.0h, adding 12-14 times of water for 2 times, extracting for 0.5-1.5h, adding 8-12 times of water for 3 times, extracting for 0.5-1.0h, filtering for each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying in 40-80 deg.C oven, pulverizing, sieving with 40-80 mesh sieve to obtain burdock extract, and drying in dryer for use.
The roasted malt extract is prepared by the following method:
weighing proper amount of parched fructus Hordei Germinatus, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 15-20 times of water for 1 time, extracting for 1.0-2h, adding 12-16 times of water for 2 times, extracting for 0.5-1.5h, adding 8-12 times of water for 3 times, extracting for 0.5-1.5h, filtering each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying at 40-80 deg.C, pulverizing, sieving with 40-80 mesh sieve to obtain parched fructus Hordei Germinatus extract, and drying with dryer.
The eucommia ulmoides extract is prepared by the following method:
weighing appropriate amount of Eucommiae cortex coarse powder, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 10-15 times of water for 1 time, extracting for 1.0-2h, adding 8-10 times of water for 2 times, extracting for 0.5-1.5h, adding 8-10 times of water for 3 times, extracting for 0.5-1.5h, filtering for each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying in 40-80 deg.C oven, pulverizing, sieving with 40-80 mesh sieve to obtain Eucommiae cortex extract, and drying in dryer for use.
The poria cocos extract is prepared by the following method:
weighing appropriate amount of Poria coarse powder, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 20-25 times of water for 1 time, extracting for 1.0-2h, adding 15-20 times of water for 2 times, extracting for 0.5-1.5h, adding 10-15 times of water for 3 times, extracting for 0.5-1.5h, filtering each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying in 40-80 deg.C oven, pulverizing, sieving with 40-80 mesh sieve to obtain Poria extract, and drying in dryer for use.
The Chinese yam extract is prepared by the following method:
weighing an appropriate amount of rhizoma Dioscoreae, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 15-20 times of water for 1 time, extracting for 1.0-2h, adding 12-16 times of water for 2 times, extracting for 0.5-1.5h, adding 8-12 times of water for 3 times, extracting for 0.5-1.5h, filtering for each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying in 40-80 deg.C oven, pulverizing, sieving with 40-80 mesh sieve to obtain rhizoma Dioscoreae extract, and drying in dryer for use.
A preparation method of granules containing traditional Chinese medicine active ingredients for invigorating spleen, replenishing qi and eliminating dampness comprises the following steps:
a) dissolving the hawthorn extract and the red date extract in the formula amount of distilled water, and stirring and dissolving to obtain a mixture for later use;
b) taking the lotus leaf extract, the Chinese yam extract, the poria cocos extract, the burdock extract, the eucommia bark extract, the coix seed extract, the red bean extract, the soluble starch, the cane sugar, the dextrin and the mixture prepared in the step a) according to the formula amount, and uniformly mixing;
c) spraying ethanol with the volume concentration of 75% of the formula amount on the uniformly mixed materials, kneading by hand until the materials are held by hands to be agglomerated and dispersed, manually extruding and sieving by using a 10-16-mesh sieve, granulating, drying in an oven at 40-65 ℃, sieving and finishing.
The sieving and granulating of the step c) specifically comprises the following steps: the granules with 10-30 meshes and 40-80 meshes are used for granulating, and the granules which can pass through 10-30 meshes and can not pass through 40-80 meshes are the granules containing the effective components of the traditional Chinese medicine and having the effects of tonifying spleen, benefiting qi and eliminating dampness.
The components in the invention are as follows:
hawthorn has been a good medicine for strengthening spleen, stimulating appetite, promoting digestion, removing food stagnation, promoting blood circulation and reducing phlegm since ancient times. The hawthorn product can enhance appetite and improve sleep when being eaten by old people frequently. The hawthorn mainly comprises flavonoids and organic acid compounds, and the flavonoids, the vitamin C, the carotene and other substances contained in the hawthorn can block and reduce the generation of free radicals, can enhance the immunity of the organism, delay aging, and can also promote gastric secretion and increase enzymes in the stomach. Ancient physicians said that Zhu Zhen Heng: haw, can reduce the appetite. If there is no food accumulation in the stomach, spleen deficiency can not transport and transform, and people do not like to eat, it is often used to counteract qi generation of spleen and stomach. The 'Rezaofan Bencao' records more hawthorn: for spleen deficiency with damp-heat, it can promote digestion, remove food stagnation and induce diuresis.
The red dates contain abundant vitamin C, so that redundant cholesterol in the body is converted into bile acid. Ancient famous doctor sun Simiao saying you in China: it should be used to save acid and increase sweet in spring to nourish spleen qi. The red dates are the good spleen-nourishing product in spring. The record of Shen nong Ben Cao Jing: the red dates are sweet in taste and warm in nature, enter spleen and stomach channels, and have the functions of tonifying middle-jiao and Qi, nourishing blood and soothing nerves and relieving drug properties. Li Shizhen says in Ben Cao gang mu: fructus Jujubae is sweet in flavor and warm in nature, has effects of invigorating spleen and replenishing qi, nourishing blood and promoting fluid production, and can be used for treating diseases such as spleen deficiency, anorexia, defecation, and deficiency of both qi and blood. The common eating of the Chinese date can treat weakness, incoordination between spleen and stomach, dyspepsia, fatigue and cough.
The lotus leaf is bitter and astringent in taste, is flat, enters liver, spleen, stomach and heart channels, and contains various alkaloids such as liensinine, protopine, nuciferine and the like, vitamin C, polysaccharide and the like. The main effects are phlegm dampness removing, summer heat clearing, dampness removing, hair ascending, yang clearing, blood cooling, bleeding stopping and the like.
The red bean contains rich B vitamins, iron, protein, fat, sugar, calcium, phosphorus, nicotinic acid and other components, has the functions of strengthening the spleen and stomach, clearing heat and promoting urination, clearing damp and expelling toxin, is suitable for people with various types of edema, including renal edema, cardiac edema, ascites due to cirrhosis, dystrophic edema and the like, contains rich potassium and saponin in the outer skin of the red bean, has a strong diuretic function, and can well improve the edema of the face and the feet caused by beriberi and the decline of the kidney function;
coix seed is sweet in nature and taste, is light and slightly cold, has the effects of promoting diuresis and reducing edema, invigorating spleen and removing dampness and the like, is a common diuresis-inducing and dampness-excreting medicine, and is used for treating spleen deficiency diarrhea, muscle soreness, dysuria, edema, beriberi, spleen deficiency diarrhea, rheumatism pain and the like. Li Shizhen is recorded in Ben Cao gang mu: coix seed has the effects of invigorating spleen and stomach, tonifying lung and clearing heat, and dispelling wind and eliminating dampness. The record of Benjing Shu Zheng (the book of Benjing Shu Zheng): replenishing qi, removing dampness, regulating the middle warmer, and invigorating spleen. People who are often tired and have no strength can eat more.
The burdock contains various vitamins and minerals required by human body such as inulin, cellulose, protein, calcium, phosphorus, iron, etc., and contains various amino acids necessary for human body. The burdock contains peroxidase, which can enhance the vitality of cellular immune mechanism, clear away oxygen free radical in vivo, prevent lipofuscin pigment from generating and accumulating in vivo, resist aging, provide an inner protection environment for resisting and clearing away oxygen free radical for organism, and improve human immunity. "compendium of materia Medica": the burdock has warm property, sweet and nontoxic taste, is effective in dredging twelve meridians, removing five internal organs and foul breath, reducing weight and resisting aging after long-term administration, and has effects of clearing heat, removing toxic substance, eliminating dampness, invigorating spleen, promoting appetite, relaxing bowels, nourishing yin, invigorating kidney, invigorating qi, lowering blood pressure, and preventing apoplexy.
Stir-baked malt is sweet and flat. It enters spleen and stomach meridians. The parched fructus Hordei Germinatus contains amylase, invertase, protein, protease, vitamin B, lecithin, parched maltose, and glucose. It can promote qi and digestion, invigorate spleen and stimulate appetite, and is used for liver depression and qi stagnation, fullness and distention in chest and hypochondrium, disharmony between liver and spleen, indigestion, abdominal pain and distention, spleen deficiency and poor appetite, and often combined with citron and finger citron to increase the effects of soothing liver and harmonizing stomach. Charred fructus Hordei Germinatus is effective in promoting digestion and resolving food stagnation. Can be used for treating dyspepsia, abdominal distention and pain. The records of the "records of the Western records of the medical science of the Zhongzhao: the stir-fried barley malt can enter spleen and stomach to digest all food accumulation and is an assistant product for tonifying spleen and stomach. Record of "medical enlightenment": tonify spleen and stomach deficiency, widen intestines and stomach, stir-fry to yellow, and take it out.
The eucommia bark is sweet in taste and warm in nature, has the effects of tonifying liver and kidney and strengthening tendons and bones, and can be used for treating lumbocrural pain or soreness and weakness caused by kidney-yang deficiency. Shen nong Ben Cao Jing (Shen nong's herbal channel) means that it is mainly used for treating lumbago and gonalgia, invigorating spleen-stomach, replenishing vital essence, strengthening tendons and bones, removing yin, itching and dampness, and dribbling urination. It is suitable for long-term administration, and has effects of reducing weight and resisting aging. Meanwhile, the pharmacopoeia of the people's republic of China (2010 edition one) records: tonify liver and kidney, strengthen tendons and bones, prevent abortion. Can be used for treating deficiency of liver and kidney, soreness of waist and knees, weakness of bones and muscles, dizziness, pregnant hemorrhage, and threatened abortion. "
Poria cocos has the functions of promoting diuresis and excreting dampness, strengthening spleen and calming heart, is used for symptoms of dysuria, edema and the like, has mild drug properties, promotes diuresis without hurting vital qi, is an essential herb for promoting diuresis and excreting dampness, can strengthen spleen and promote diuresis and excreting dampness, and has a treatment effect on loose stool and diarrhea, spleen deficiency and anorexia caused by spleen deficiency transportation and transformation dysfunction. The book of materia Medica Yan: fu Ling has the action of moving water, so it is also indicated for tonifying heart and spleen. The book materia Medica is as follows: the Chinese medicinal composition has the effects of inducing resuscitation and removing dampness, and inducing resuscitation and restoring heart and intelligence, and promoting the production of body fluid; to remove dampness, it can expel water and dry spleen, strengthen the middle-jiao and invigorate the stomach. The medical inspiration is: to remove dampness, induce diuresis, harmonize the middle energizer and replenish qi. It is indicated for yellow or red urine. Poria can also enhance immunity.
The Chinese yam is rich in protein, vitamins, various amino acids and mineral substances, can tonify qi of spleen, lung and kidney, and nourish yin of spleen, lung and kidney, and is a treasure for tonifying both qi and yin. The Chinese yam contains amylase, polyphenol oxidase and other substances, is beneficial to the digestion and absorption functions of the spleen and the stomach, and is a medicine and food dual-purpose product for tonifying the spleen and the stomach. The rhizoma Dioscoreae has effects of nourishing, strengthening body, promoting digestion, invigorating spleen, nourishing stomach, invigorating lung and kidney, invigorating middle warmer, replenishing qi, invigorating spleen, tonifying deficiency, invigorating kidney, replenishing vital essence, benefiting heart, tranquilizing mind, and treating spleen and stomach weakness, anorexia, diarrhea and loose stool. The compendium of materia Medica records: invigorating spleen and tonifying body, replenishing essence and invigorating kidney, treating various diseases, and treating five kinds of strain and seven kinds of injuries. It is suitable for patients with spleen yang deficiency or stomach yin deficiency. The rhizoma Dioscoreae has effects of inducing production of interferon and enhancing immunity. The choline and the lecithin contained in the health-care food are helpful for improving the memory of people, can build the body and delay aging after being frequently eaten, and are good health-care products favored by people.
Soluble starch, dextrin and sucrose are used as green edible auxiliary materials, not only can be used as a filling agent of granules, but also can fully regulate bitter taste of medicinal components, so that patients can avoid rejecting the medicine due to taste and smell when taking the medicine.
In the preparation process, the hawthorn extract and the red date extract are dissolved in the formula amount of distilled water, and the extracts cannot be crushed because the extracts contain sugar, and only can be dissolved and added as a wetting agent or an adhesive to facilitate further granulation.
Compared with the prior art, the traditional Chinese medicine composition is added with a plurality of traditional Chinese medicine components such as lotus leaf extract, Chinese yam extract, poria cocos extract, burdock extract, eucommia bark extract, coix seed extract, red bean extract, hawthorn extract and red date extract, and compared with the prior art, the traditional Chinese medicine composition adopts a plurality of traditional Chinese medicine effective components, so that the traditional Chinese medicine composition can tonify qi and invigorate spleen, eliminate dampness and reduce phlegm, and condition phlegm-damp type physique; eliminating local edema, improving symptoms caused by spleen deficiency, such as hyperhidrosis, excessive phlegm, asthenia, lethargy, listlessness, etc., invigorating spleen, and eliminating water dampness without side effect. Through the use of 150 users, the spleen tonifying, qi benefiting and dampness eliminating granules prepared by the invention are found to have the effects of eliminating dampness, reducing swelling, reducing phlegm and improving sleep.
Detailed Description
The present invention will be further described with reference to the following examples.
According to the rules of pharmacopoeia, in the preparation process, the coarse powder can completely pass through a No. two sieve, but is mixed with powder which can pass through a No. four sieve by no more than 40%; the concentration of the ethanol is volume concentration; all extractions were carried out under slightly boiling conditions.
Example 1
A granule containing traditional Chinese medicine effective components for invigorating spleen, replenishing qi and eliminating dampness comprises the following raw materials in parts by weight:
Figure BDA0001237347970000091
a preparation method of granules containing traditional Chinese medicine active ingredients for invigorating spleen, replenishing qi and eliminating dampness comprises the following steps:
1.1 preparation of hawthorn extract:
weighing 100g of hawthorn, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 1.5h, adding 15 times of water for 2 times, extracting for 1.0h, adding 12 times of water for 3 times, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be viscous, placing on a 80 ℃ water bath kettle to steam until the filtrate does not flow, placing in a 60 ℃ oven to dry, pulverizing, sieving with a 80-mesh sieve to obtain the hawthorn extract, and placing in a dryer for later use.
1.2 preparation of red date extract:
weighing 100g of red dates, cutting pulp, soaking for 0.6h, heating, decocting and extracting for 3 times, adding 15 times of water for the 1 st time, extracting for 1.5h, adding 12 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 80 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 60 ℃ oven, drying, pulverizing, sieving with a 80-mesh sieve to obtain a red date extract, and placing in a dryer for later use.
1.3 preparation of lotus leaf extract:
weighing 100g of lotus leaves, soaking for 0.3h, heating, decocting and extracting for 3 times, adding 25 times of water for 1 time, extracting for 1.5h, adding 20 times of water for 2 times, extracting for 1.0h, adding 15 times of water for 3 times, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be viscous, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, drying in a 60 ℃ oven, pulverizing, sieving with a 80-mesh sieve to obtain a lotus leaf extract, and placing in a dryer for later use.
1.4 preparation of red bean extract:
weighing 80g of red beans, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 15 times of water for the 1 st time, extracting for 1.5h, adding 12 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be viscous state, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 60 ℃ oven, drying, pulverizing, sieving with a 80-mesh sieve to obtain a red bean extract, and placing in a dryer for later use.
1.5 preparation of Coix seed extract:
weighing 60g of coix seeds, soaking for 0.2h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 1.5h, adding 15 times of water for 2 times, extracting for 1.0h, adding 12 times of water for 3 times, extracting for 1.0h, filtering each time, combining filtrates, concentrating to viscous state, placing on a 100 ℃ water bath kettle, steaming to non-flowing state, drying in a 60 ℃ oven, pulverizing, sieving with a 80-mesh sieve to obtain coix seed extract, and placing in a dryer for later use.
1.6 preparation of burdock extract:
weighing burdock coarse powder 100g, pulverizing, soaking for 0.6h, heating, decocting and extracting for 3 times, adding 20 times of water for the 1 st time, extracting for 2.0h, adding 14 times of water for the 2 nd time, extracting for 1.5h, adding 12 times of water for the 3 rd time, extracting for 0.5h, filtering each time, mixing filtrates, concentrating to viscous state, steaming in 100 deg.C water bath to non-flowing state, oven drying in 65 deg.C oven, pulverizing, sieving with 60 mesh sieve to obtain burdock extract, and drying in dryer for use.
1.7 preparation of roasted malt extract:
weighing 100g of parched malt, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 15 times of water for 1 time, extracting for 2.0h, adding 12 times of water for 2 times, extracting for 1.5h, adding 10 times of water for 3 times, extracting for 0.5h, filtering each time, mixing filtrates, concentrating to viscous state, steaming on 100 deg.C water bath to non-flowing state, oven drying at 65 deg.C, pulverizing, sieving with 60 mesh sieve to obtain parched malt extract, and drying in dryer for use.
1.8 preparation of eucommia ulmoides extract:
weighing 80g of eucommia ulmoides coarse powder, cutting and soaking for 0.5h, heating, decocting and extracting for 3 times, adding 15 times of water for 1 time, extracting for 2.0h, adding 10 times of water for 2 times, extracting for 1.5h, adding 10 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 65 ℃ oven, drying, crushing, sieving with a 60-mesh sieve to obtain an eucommia ulmoides extract, and placing in a dryer for later use.
1.9 preparation of Poria cocos extract:
weighing 60g of poria cocos coarse powder, crushing, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 25 times of water for 1 time, extracting for 2.0h, adding 20 times of water for 2 times, extracting for 1.5h, adding 15 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 65 ℃ oven, drying, crushing, sieving with a 60-mesh sieve to obtain the poria cocos extract, and placing in a dryer for later use.
1.10 preparation of yam extract:
weighing 80g of Chinese yam, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 2.0h, adding 16 times of water for 2 times, extracting for 1.5h, adding 12 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, concentrating to viscous state, steaming on a 100 ℃ water bath to non-flowing state, drying in a 65 ℃ oven, pulverizing, sieving with a 60-mesh sieve to obtain Chinese yam extract, and drying in a dryer for later use.
1.11 preparation method of granules containing effective components of traditional Chinese medicines for invigorating spleen, replenishing qi and eliminating dampness:
a) dissolving the hawthorn extract and the red date extract in the prescribed amount in 22ml of water, and stirring and dissolving to obtain a mixture for later use;
b) taking the lotus leaf extract, the Chinese yam extract, the poria cocos extract, the burdock extract, the eucommia bark extract, the coix seed extract, the red bean extract, the soluble starch, the sucrose and the dextrin which are prepared in the step a) according to the formula ratio, and uniformly mixing;
c) placing the uniformly mixed mixture in a tray, spraying 6ml of 75% ethanol, kneading by hand until the mixture is held by hands to be agglomerated and dispersed, manually extruding and sieving by using a 13-mesh sieve for granulation, placing in a 60-DEG C oven for drying, and finishing granules by using a 10-mesh sieve and an 80-mesh sieve, wherein the granules which can pass through the 10-mesh sieve and can not pass through the 80-mesh sieve are the granules containing the effective components of the traditional Chinese medicine for tonifying spleen, replenishing qi and eliminating dampness.
Example 2
A granule containing traditional Chinese medicine effective components for invigorating spleen, replenishing qi and eliminating dampness comprises the following raw materials in parts by weight:
Figure BDA0001237347970000121
Figure BDA0001237347970000131
a preparation method of granules containing traditional Chinese medicine active ingredients for invigorating spleen, replenishing qi and eliminating dampness comprises the following steps:
2.1 preparation of hawthorn extract:
weighing 80g of hawthorn, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 1.5h, adding 15 times of water for 2 times, extracting for 1.0h, adding 12 times of water for 3 times, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be viscous, placing on a 80 ℃ water bath kettle to steam to be in a non-flowing state, placing in a 60 ℃ oven for drying, crushing, sieving with a 80-mesh sieve to obtain the hawthorn extract, and placing in a dryer for later use.
2.2 preparation of red date extract:
weighing 80g of red dates, cutting pulp, soaking for 0.6h, heating, decocting and extracting for 3 times, adding 15 times of water for the 1 st time, extracting for 1.5h, adding 12 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 80 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 60 ℃ oven, drying, pulverizing, sieving with a 80-mesh sieve to obtain a red date extract, and placing in a dryer for later use.
2.3 preparation of lotus leaf extract:
weighing 80g of lotus leaves, soaking for 0.3h, heating, decocting and extracting for 3 times, adding 25 times of water for 1 time, extracting for 1.5h, adding 20 times of water for 2 times, extracting for 1.0h, adding 15 times of water for 3 times, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be viscous, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, drying in a 60 ℃ oven, pulverizing, sieving with a 80-mesh sieve to obtain the lotus leaf extract, and placing in a dryer for later use.
2.4 preparation of red bean extract:
weighing 60g of red beans, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 15 times of water for the 1 st time, extracting for 1.5h, adding 12 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be viscous, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 60 ℃ oven, drying, pulverizing, sieving with a 80-mesh sieve to obtain a red bean extract, and placing in a dryer for later use.
2.5 preparation of Coix seed extract:
weighing 40g of coix seeds, soaking for 0.2h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 1.5h, adding 15 times of water for 2 times, extracting for 1.0h, adding 12 times of water for 3 times, extracting for 1.0h, filtering each time, combining filtrates, concentrating to viscous state, placing on a 100 ℃ water bath kettle, steaming to non-flowing state, drying in a 60 ℃ oven, pulverizing, sieving with a 80-mesh sieve to obtain coix seed extract, and placing in a dryer for later use.
2.6 preparation of burdock extract:
weighing 80g of burdock coarse powder, crushing, soaking for 0.6h, heating, decocting and extracting for 3 times, adding 20 times of water for the 1 st time, extracting for 2.0h, adding 14 times of water for the 2 nd time, extracting for 1.5h, adding 12 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 65 ℃ oven, drying, crushing, sieving with a 60-mesh sieve to obtain the burdock extract, and placing in a dryer for later use.
2.7 preparation of roasted malt extract:
weighing 80g of roasted malt, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 2.0h, adding 16 times of water for 2 times, extracting for 1.5h, adding 12 times of water for 3 times, extracting for 0.5h, filtering each time, mixing filtrates, concentrating to viscous state, steaming on a 100 deg.C water bath to non-flowing state, oven drying in a 65 deg.C oven, pulverizing, sieving with 60 mesh sieve to obtain roasted malt extract, and drying in a dryer for use.
2.8 preparation of eucommia ulmoides extract:
weighing 60g of eucommia ulmoides coarse powder, cutting and soaking for 0.5h, heating, decocting and extracting for 3 times, adding 15 times of water for 1 time, extracting for 2.0h, adding 10 times of water for 2 times, extracting for 1.5h, adding 10 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 65 ℃ oven, drying, crushing, sieving with a 60-mesh sieve to obtain an eucommia ulmoides extract, and placing in a dryer for later use.
2.9 preparation of Poria cocos wolf extract:
weighing 40g of poria cocos coarse powder, crushing, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 25 times of water for 1 time, extracting for 2.0h, adding 20 times of water for 2 times, extracting for 1.5h, adding 15 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 100 ℃ water bath kettle to steam to be in a non-flowing state, placing in a 65 ℃ oven for drying, crushing, sieving with a 60-mesh sieve to obtain the poria cocos extract, and placing in a dryer for later use.
2.10 preparation of yam extract:
weighing 60g of Chinese yam, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 2.0h, adding 16 times of water for 2 times, extracting for 1.5h, adding 12 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, concentrating to viscous state, steaming on a 100 ℃ water bath to non-flowing state, drying in a 65 ℃ oven, pulverizing, sieving with a 60-mesh sieve to obtain Chinese yam extract, and drying in a dryer for later use.
2.11 preparation method of granule containing effective components of Chinese medicinal materials for invigorating spleen, invigorating qi and eliminating dampness:
a) dissolving the hawthorn extract and the red date extract in the prescription amount in 30ml of water, and stirring and dissolving to obtain a mixture for later use;
b) taking the lotus leaf extract, the Chinese yam extract, the poria cocos extract, the burdock extract, the eucommia bark extract, the coix seed extract, the red bean extract, the soluble starch, the sucrose and the dextrin which are prepared in the step a) according to the formula ratio, and uniformly mixing;
c) placing the uniformly mixed mixture in a tray, spraying 3ml of 75% ethanol, kneading by hand until the mixture is held by hands to be agglomerated and dispersed, manually extruding and sieving by using a 13-mesh sieve for granulation, placing in a 60-DEG C oven for drying, and finishing granules by using a 10-mesh sieve and an 80-mesh sieve, wherein the granules which can pass through the 10-mesh sieve and can not pass through the 80-mesh sieve are the granules containing the effective components of the traditional Chinese medicine for tonifying spleen, replenishing qi and eliminating dampness.
Example 3
A granule containing traditional Chinese medicine effective components for invigorating spleen, replenishing qi and eliminating dampness comprises the following raw materials in parts by weight:
Figure BDA0001237347970000161
3.1 preparation of hawthorn extract:
weighing 60g of hawthorn, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 1.5h, adding 15 times of water for 2 times, extracting for 1.0h, adding 12 times of water for 3 times, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be viscous, placing on a 80 ℃ water bath kettle to steam until the filtrate does not flow, placing in a 60 ℃ oven for drying, pulverizing, sieving with a 80-mesh sieve to obtain the hawthorn extract, and placing in a dryer for later use.
3.2 preparation of red date extract:
weighing 60g of red dates, cutting pulp, soaking for 0.6h, heating, decocting and extracting for 3 times, adding 15 times of water for the 1 st time, extracting for 1.5h, adding 12 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 80 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 60 ℃ oven, drying, pulverizing, sieving with a 80-mesh sieve to obtain a red date extract, and placing in a dryer for later use.
3.3 preparation of the lotus leaf extract:
weighing 60g of lotus leaves, soaking for 0.3h, heating, decocting and extracting for 3 times, adding 25 times of water for 1 time, extracting for 1.5h, adding 20 times of water for 2 times, extracting for 1.0h, adding 15 times of water for 3 times, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be viscous, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, drying in a 60 ℃ oven, pulverizing, sieving with a 80-mesh sieve to obtain the lotus leaf extract, and placing in a dryer for later use.
3.4 preparation of red bean extract:
weighing 40g of red bean, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 15 times of water for the 1 st time, extracting for 1.5h, adding 12 times of water for the 2 nd time, extracting for 1.0h, adding 10 times of water for the 3 rd time, extracting for 1.0h, filtering each time, combining filtrates, concentrating to be viscous state, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 60 ℃ oven, drying, pulverizing, sieving with a 80-mesh sieve to obtain a lotus leaf extract, and placing in a dryer for later use.
3.5 preparation of Coix seed extract:
weighing 20g of coix seeds, soaking for 0.2h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 1.5h, adding 15 times of water for 2 times, extracting for 1.0h, adding 12 times of water for 3 times, extracting for 1.0h, filtering each time, combining filtrates, concentrating to viscous state, placing on a 100 ℃ water bath kettle, steaming to non-flowing state, drying in a 60 ℃ oven, pulverizing, sieving with a 80-mesh sieve to obtain coix seed extract, and placing in a dryer for later use.
3.6 preparation of burdock extract:
weighing 60g of burdock coarse powder, crushing, soaking for 0.6h, heating, decocting and extracting for 3 times, adding 20 times of water for the 1 st time, extracting for 2.0h, adding 14 times of water for the 2 nd time, extracting for 1.5h, adding 12 times of water for the 3 rd time, extracting for 0.5h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 65 ℃ oven, drying, crushing, sieving with a 60-mesh sieve to obtain the astragalus extract, and placing in a dryer for later use.
3.7 preparation of roasted malt extract:
weighing 60g of roasted malt, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 2.0h, adding 16 times of water for 2 times, extracting for 1.5h, adding 12 times of water for 3 times, extracting for 0.5h, filtering each time, mixing filtrates, concentrating to viscous state, steaming on a 100 deg.C water bath to non-flowing state, oven drying in a 65 deg.C oven, pulverizing, sieving with 60 mesh sieve to obtain roasted malt extract, and drying in a dryer for use.
3.8 preparation of eucommia ulmoides extract:
weighing eucommia ulmoides coarse powder 40g, cutting and soaking for 0.5h, heating, decocting and extracting for 3 times, adding 15 times of water for 1 time, extracting for 2.0h, adding 10 times of water for 2 times, extracting for 1.5h, adding 10 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 65 ℃ oven, drying, pulverizing, sieving with a 60-mesh sieve to obtain an eucommia ulmoides extract, and placing in a dryer for later use.
3.9 preparation of Poria cocos wolf extract:
weighing 25g of poria cocos coarse powder, crushing, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 25 times of water for 1 time, extracting for 2.0h, adding 20 times of water for 2 times, extracting for 1.5h, adding 15 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, concentrating to be in a viscous state, placing on a 100 ℃ water bath kettle, steaming to be in a non-flowing state, placing in a 65 ℃ oven, drying, crushing, sieving with a 60-mesh sieve to obtain the poria cocos extract, and placing in a dryer for later use.
3.10 preparation of yam extract:
weighing 40g of Chinese yam, soaking for 0.5h, heating, decocting and extracting for 3 times, adding 20 times of water for 1 time, extracting for 2.0h, adding 16 times of water for 2 times, extracting for 1.5h, adding 12 times of water for 3 times, extracting for 0.5h, filtering each time, combining filtrates, concentrating to viscous state, placing on a 100 ℃ water bath kettle, steaming to non-flowing state, drying in a 65 ℃ oven, pulverizing, sieving with a 60-mesh sieve to obtain Chinese yam extract, and placing in a dryer for later use.
3.11 preparation method of granule containing Chinese medicinal effective components for invigorating spleen, invigorating qi and eliminating dampness:
a) dissolving the hawthorn extract and the red date extract in the formula amount in 18ml of water, and stirring and dissolving to obtain a mixture for later use;
b) taking the lotus leaf extract, the Chinese yam extract, the poria cocos extract, the burdock extract, the eucommia bark extract, the coix seed extract, the red bean extract, the soluble starch, the sucrose and the dextrin which are prepared in the step a) according to the formula ratio, and uniformly mixing;
c) placing the uniformly mixed mixture in a tray, spraying 5ml of 75% ethanol, kneading by hand until the mixture is held by hands to be agglomerated and dispersed, manually extruding and sieving by using a 13-mesh sieve for granulation, placing in a 60-DEG C oven for drying, and finishing granules by using a 10-mesh sieve and an 80-mesh sieve, wherein the granules which can pass through the 10-mesh sieve and can not pass through the 80-mesh sieve are the granules containing the effective components of the traditional Chinese medicine for tonifying spleen, replenishing qi and eliminating dampness.
Example 4
The physical and chemical indexes of the examples 1, 2 and 3 are as follows:
4.1 Properties
The product is brown granule with proper size, uniform texture, and complete appearance, and has good fragrance and sweet taste.
4.2 examination of particle size distribution
Stacking the medicine sieves with different sieve numbers from high to low according to the sequence of the mesh number from small to large, pouring the prepared granules into the uppermost sieve, and slowly shaking the stacked medicine sieves to separate the granules with different sizes, wherein the percentage of each obtained sieve number is as shown in table 1.
TABLE 1 percentage of particles in each sieve number
Figure BDA0001237347970000191
Figure BDA0001237347970000201
4.3 granule flowability inspection
The method comprises the steps of adopting a fixed conical bottom method, enabling a base plate to be a culture dish, enabling two glass funnels to be overlapped in a vertically staggered mode, fixing the glass funnels on an iron support, slowly adding a sample from an upper funnel, enabling the sample to be gradually accumulated on the base plate through buffering of the two funnels, and forming a cone until the highest cone is obtained. The cone height h was measured three times for each sample, and the angle of repose a was determined by averaging a ═ arctg (h/r). The obtained value was 0.513, arctg0.513 was 27 °, and the fluidity was good.
4. Examination of the effects of invigorating spleen and replenishing Qi
Selecting volunteers (45-65 years old and 100 persons), and after the oral granules are flushed with water for several days, the patients obviously feel that the local edema of the joints is obviously improved; the hyperhidrosis physique is also effectively improved, and the symptoms of the patient with expectoration all the year round are relieved; the sleep quality is obviously improved.
5. Examination of the comprehensive Effect of the granule
The efficacy of the granules containing the effective ingredients of the traditional Chinese medicines prepared in examples 1, 2, and 3, which have the effects of invigorating spleen, replenishing qi, and eliminating dampness, is evaluated by the feeling of trial use. 150 men and women (half of men and women) of 55-75 years old are selected as trial objects by adopting a civil survey grading method, are divided into four groups in an arbitrary equal way, and the granules prepared in the examples 1, 2 and 3 are respectively taken. The composition is administered three times a day for two months. The using effects of the ingredients are divided into 5 points: the score of 5 is the highest score, which represents good and very satisfactory; 4, the division is better; 3 is acceptable; when the amount is less than 3 points, the results are not acceptable. The average score of each item is as follows. The results are shown in Table 2:
TABLE 2 examination of the comprehensive results
Figure BDA0001237347970000211
The granules for tonifying spleen, benefiting qi and eliminating dampness prepared by the invention have the effects of eliminating dampness, reducing swelling, reducing phlegm and improving sleep, and have no side effect.

Claims (2)

1. The spleen-tonifying, qi-tonifying and dampness-eliminating granules containing the traditional Chinese medicine active ingredients are characterized by comprising the following raw materials in parts by weight:
Figure FDA0002378316170000011
the hawthorn extract is prepared by the following method:
weighing an appropriate amount of hawthorn, soaking for 0.15-0.8h, then heating, decocting and extracting for 3 times, adding 15-20 times of water for 1 time, extracting for 1.0-2.0h, adding 12-15 times of water for 2 times, extracting for 0.5-1.5h, adding 8-12 times of water for 3 times, extracting for 0.5-1.5h, filtering for each time, combining filtrates, concentrating to a viscous state, placing on a water bath kettle at 80-100 ℃ to steam to a non-flowing state, placing in an oven at 40-80 ℃ for drying, pulverizing, sieving with a 40-80 mesh sieve to obtain the hawthorn extract, and placing in a dryer for later use;
the burdock extract is prepared by the following method:
weighing appropriate amount of burdock coarse powder, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 14-20 times of water for 1 time, extracting for 1.0-2.0h, adding 12-14 times of water for 2 times, extracting for 0.5-1.5h, adding 8-12 times of water for 3 times, extracting for 0.5-1.0h, filtering for each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying in 40-80 deg.C oven, pulverizing, sieving with 40-80 mesh sieve to obtain burdock extract, and drying in dryer;
the red date extract is prepared by the following method:
weighing an appropriate amount of red dates, cutting off pulp, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 12-15 times of water for 1 time, extracting for 1.0-2.0h, adding 10-12 times of water for 2 times, extracting for 0.5-1.5h, adding 8-10 times of water for 3 times, extracting for 0.5-1.5h, filtering for each time, combining filtrates, concentrating to viscous state, placing on a water bath kettle at 80-100 deg.C to steam to a non-flowing state, placing in an oven at 40-80 deg.C for drying, pulverizing, sieving with a 40-80 mesh sieve to obtain red date extract, and placing in a dryer for later use;
the lotus leaf extract is prepared by the following method:
weighing an appropriate amount of lotus leaves, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 20-25 times of water for 1 time, extracting for 1.0-2.0h, adding 15-20 times of water for 2 times, extracting for 0.5-1.5h, adding 10-15 times of water for 3 times, extracting for 0.5-1.5h, filtering for each time, combining filtrates, concentrating to viscous state, steaming on a water bath kettle at 80-100 deg.C to non-flowing state, drying in an oven at 40-80 deg.C, pulverizing, sieving with a 40-80 mesh sieve to obtain lotus leaf extract, and drying in a dryer for later use;
the red bean extract is prepared by the following method:
weighing an appropriate amount of red beans, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 12-15 times of water for 1 time, extracting for 1.0-2.0h, adding 10-12 times of water for 2 times, extracting for 0.5-1.5h, adding 8-10 times of water for 3 times, filtering each time, extracting for 0.5-1.5h, combining filtrates, concentrating to viscous state, steaming on a water bath kettle at 80-100 deg.C to non-flowing state, drying in an oven at 40-80 deg.C, pulverizing, sieving with a 40-80 mesh sieve to obtain red bean extract, and placing in a dryer for later use;
the coix seed extract is prepared by the following steps:
weighing an appropriate amount of coix seeds, soaking for 0.15-0.8h, then heating, decocting and extracting for 3 times, adding 15-20 times of water for 1 time, extracting for 1.0-2.0h, adding 12-15 times of water for 2 times, extracting for 0.5-1.5h, adding 8-12 times of water for 3 times, extracting for 0.5-1.0h, filtering for each time, combining filtrates, concentrating to a viscous state, placing on a water bath kettle at 80-100 ℃ to steam to a non-flowing state, placing in an oven at 40-80 ℃ for drying, pulverizing, sieving with a 40-80 mesh sieve to obtain coix seed extract, and placing in a dryer for later use;
the roasted malt extract is prepared by the following method:
weighing proper amount of parched fructus Hordei Germinatus, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 15-20 times of water for 1 time, extracting for 1.0-2h, adding 12-16 times of water for 2 times, extracting for 0.5-1.5h, adding 8-12 times of water for 3 times, extracting for 0.5-1.5h, filtering each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying in 40-80 deg.C oven, pulverizing, sieving with 40-80 mesh sieve to obtain parched fructus Hordei Germinatus extract, and drying in dryer;
the eucommia ulmoides extract is prepared by the following method:
weighing an appropriate amount of eucommia ulmoides coarse powder, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 10-15 times of water for 1 time, extracting for 1.0-2h, adding 8-10 times of water for 2 times, extracting for 0.5-1.5h, adding 8-10 times of water for 3 times, extracting for 0.5-1.5h, filtering for each time, combining filtrates, concentrating to a viscous state, placing on a water bath kettle at 80-100 ℃ for steaming to a non-flowing state, placing in an oven at 40-80 ℃ for drying, crushing, sieving with a 40-80 mesh sieve to obtain an eucommia ulmoides extract, and placing in a dryer for later use;
the poria cocos extract is prepared by the following method:
weighing appropriate amount of Poria coarse powder, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 20-25 times of water for 1 time, extracting for 1.0-2h, adding 15-20 times of water for 2 times, extracting for 0.5-1.5h, adding 10-15 times of water for 3 times, extracting for 0.5-1.5h, filtering each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying in 40-80 deg.C oven, pulverizing, sieving with 40-80 mesh sieve to obtain Poria extract, and drying in dryer;
the Chinese yam extract is prepared by the following method:
weighing an appropriate amount of rhizoma Dioscoreae, soaking for 0.15-0.8h, heating, decocting and extracting for 3 times, adding 15-20 times of water for 1 time, extracting for 1.0-2h, adding 12-16 times of water for 2 times, extracting for 0.5-1.5h, adding 8-12 times of water for 3 times, extracting for 0.5-1.5h, filtering for each time, mixing filtrates, concentrating to viscous state, steaming in 80-100 deg.C water bath to non-flowing state, oven drying in 40-80 deg.C oven, pulverizing, sieving with 40-80 mesh sieve to obtain rhizoma Dioscoreae extract, and drying in dryer for use.
2. The preparation method of the granules containing the effective ingredients of the traditional Chinese medicine, which are disclosed by claim 1, is characterized by comprising the following steps of:
a) dissolving the hawthorn extract and the red date extract in the formula amount of distilled water, and stirring and dissolving to obtain a mixture for later use;
b) taking the lotus leaf extract, the Chinese yam extract, the poria cocos extract, the burdock extract, the eucommia bark extract, the coix seed extract, the red bean extract, the soluble starch, the sucrose and the dextrin which are prepared in the step a) according to the formula ratio, and uniformly mixing;
c) spraying ethanol with the volume concentration of 75% of the formula amount on the uniformly mixed materials, kneading by hand until the materials are held by hands to be agglomerated and dispersed, manually extruding and sieving by using a 10-16-mesh sieve, granulating, drying in an oven at 40-65 ℃, sieving and finishing.
CN201710122084.XA 2017-03-03 2017-03-03 A granule containing Chinese medicinal effective components for invigorating spleen, invigorating qi and eliminating dampness, and its preparation method Active CN106729190B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710122084.XA CN106729190B (en) 2017-03-03 2017-03-03 A granule containing Chinese medicinal effective components for invigorating spleen, invigorating qi and eliminating dampness, and its preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710122084.XA CN106729190B (en) 2017-03-03 2017-03-03 A granule containing Chinese medicinal effective components for invigorating spleen, invigorating qi and eliminating dampness, and its preparation method

Publications (2)

Publication Number Publication Date
CN106729190A CN106729190A (en) 2017-05-31
CN106729190B true CN106729190B (en) 2020-07-21

Family

ID=58960781

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710122084.XA Active CN106729190B (en) 2017-03-03 2017-03-03 A granule containing Chinese medicinal effective components for invigorating spleen, invigorating qi and eliminating dampness, and its preparation method

Country Status (1)

Country Link
CN (1) CN106729190B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107349292A (en) * 2017-07-27 2017-11-17 皖南医学院 A kind of slim tea for pressing down esterified blood lipid and reducing blood sugar solution oil and preparation method thereof
CN115251382A (en) * 2022-06-16 2022-11-01 吴玉琼 Novel dampness-eliminating health-preserving Chinese yam and tremella soup and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104126790A (en) * 2014-04-01 2014-11-05 新时代健康产业（集团）有限公司 Phlegm-dampness constitution health food and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104126790A (en) * 2014-04-01 2014-11-05 新时代健康产业（集团）有限公司 Phlegm-dampness constitution health food and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
从体质学角度探讨高脂血症患者的中医食疗方案;李静娴，沈翠珍;《浙江中医药大学学报》;20130731;第37卷(第7期);p927-928 *
历代医家论痰湿体质;聂金娜;《中医杂志》;20130228;第54卷(第3期);p263-265 *

Also Published As

Publication number Publication date
CN106729190A (en) 2017-05-31

Similar Documents

Publication Publication Date Title
CN103191362A (en) Traditional Chinese medicine granule for treating infantile diarrhea and preparation method of traditional Chinese medicine granule
CN113318201A (en) Health food for reducing uric acid and preparation method thereof
CN106177053A (en) A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Pericarpium Citri Reticulatae
CN106729190B (en) A granule containing Chinese medicinal effective components for invigorating spleen, invigorating qi and eliminating dampness, and its preparation method
CN106236875A (en) A kind of Chinese medicine composition of liver heat removing and eyesight improving and preparation method thereof
CN106177477A (en) A kind of health composition for blood sugar lowering, blood fat reducing and blood pressure lowering
CN106173605A (en) A kind of Hyperglycemic health care compositions comprising Radix Puerariae and Herba Dendrobii
CN112057501A (en) Traditional Chinese medicine composition, traditional Chinese medicine ointment and external hot compress plaster for treating muscular atrophy and myasthenia
CN104491236A (en) Traditional Chinese medicine preparation for treating essential hypertension and preparation method for traditional Chinese medicine preparation
CN104258359A (en) Traditional Chinese medicine combination for curing pregnancy reaction and preparation method of preparations thereof
CN103932176B (en) Health-care food composition for assisting to lower blood flat, as well as preparation method and application of composition
CN112023010A (en) Traditional Chinese medicine composition for slimming, preparation method thereof, oral medicine and application
CN102552743A (en) Medicinal composition for treating diabetes and preparation method thereof
CN105250569A (en) Traditional Chinese medicine pill for treating peripheral neuritis and preparation method
CN105381441A (en) Traditional Chinese medicine capsule for preventing and treating cyesedema and preparation method of traditional Chinese medicine capsule
CN106177476A (en) A kind of Hyperglycemic health care compositions comprising Herba Dendrobii and Pericarpium Citri Reticulatae
CN104906547A (en) Medicinal granules for treating spleen-qi deficiency type diarrhea associated with menstruation and preparation method of medicinal granules
CN114712466B (en) Medicine with weight-reducing and beautifying effects and preparation method thereof
CN103520644B (en) Traditional Chinese medicine composition used for treating phlegm stagnation type hyperlipidaemia and preparation method of composition
CN106173606A (en) A kind of Hyperglycemic health care compositions comprising Cortex Mori and Herba Dendrobii
CN106177480A (en) A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Herba Dendrobii
CN105125693A (en) Traditional Chinese medicine composition for treating acute gastritis and preparing method thereof
CN106173604A (en) A kind of Hyperglycemic health care compositions comprising Cortex Mori and Rhizoma Polygonati Odorati
CN105250749A (en) Traditional Chinese medicine for treating thyroid adenoma and preparation method thereof
CN104940777A (en) Electuary capable of treating liver-yang hyperactivity and spleen weakness type diarrhea during menstruation and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant