CN102552743A - Medicinal composition for treating diabetes and preparation method thereof - Google Patents
Medicinal composition for treating diabetes and preparation method thereof Download PDFInfo
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- CN102552743A CN102552743A CN2012100147685A CN201210014768A CN102552743A CN 102552743 A CN102552743 A CN 102552743A CN 2012100147685 A CN2012100147685 A CN 2012100147685A CN 201210014768 A CN201210014768 A CN 201210014768A CN 102552743 A CN102552743 A CN 102552743A
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Abstract
The invention belongs to the field of Chinese medicines. Raw materials belong to medicinal-edible Chinese medicines and foods. A medicinal composition is prepared from bitter gourd, Chinese yam, coix seed, dark plum, indian buead and the like. The medicinal composition has the functions of reducing blood sugar and regulating blood fat, can be taken as a supplement of a daily food, can be used for greatly improving consumptive thirst, constipation, digestion promotion, appetite increasing and the like, and has the total regulating function of over 90 percent on suitable people. Compared with the prior art, the medicinal composition has the advantages of definite curative effect, freeness from toxic and side effects, convenience for taking and low price, and diabetics can be prevented and treated fundamentally.
Description
Technical field
The present invention relates to the pharmaceutical composition of a kind of prevention and treatment diabetes.
Background technology
Diabetes are common endocrinopathyes, and the traditional Chinese medical science is called diabetes.The maximum harm of diabetes is the blood vessel and the neuropathy of the undesired initiation of blood glucose, causes the decline of the heart, liver, renal function, and immunity degradation causes the appearance of complication such as arteriosclerosis, coronary heart disease, hemiplegia, threat to life then.Along with the raising of living standards of the people, the sickness rate of diabetes improves, and has become the disease of the 3rd position influence human health after cardiovascular disease and cancer at present.Performances such as diabetes are to act on that body causes hypoinsulinism, insulin resistant etc. and a series of metabolism disorder syndromes such as the sugar that causes, protein, fat, power and water Xie Zhi by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, Nervous and Mental Factors or the like various virulence factors, are main feature clinically with the hyperglycemia, and polyuria, polydipsia, polyphagia can appear in model case, become thin; I.e. " three-many-one-little " symptom; Chinese medicine is discussed comparatively detailed to the etiology and pathogenesis of primary disease, it is generally acknowledged it mainly is owing to the plain body deficiency of YIN, and the five internal organs are weak; Multiple because of eating and drinking without temperance; The surfeit delicious food, disorder of emotion, labor is desired excessively; And causing deficiency of kidney-YIN, the lung dryness of the stomach is warm; The pathogenesis emphasis is that the deficiency of YIN is scorching, and is this with the deficiency of YIN, scorchingly is mark; With the passing of time disease prolongs, deficiency of YIN affecting YANG, deficiency in both YIN and YANG; The deficiency of YIN is scorching, and the bright liquid in consumption Tianjin makes blood viscous, the capable not smooth stasis of blood that forms of blood; Deficiency of YIN affecting YANG, the yang deficiency cold coagulation also can cause sun in the blood stasis.China's diabetics has more than 4,000 ten thousand people approximately, and patient's number is still in sustainable growth.At present, society generally acknowledged diabetes be pertinacious disease, call the disease of not healing for all the life, secondly be that complication is many, ill accumulating in the course of time can cause a plurality of organ diseases, and sees work with cardiovascular and cerebrovascular disease.In industrialized country, diabetes have become the third-largest dead factor, are only second to heart disease and cancer.
The western medical treatment diabetes are main with insulin injection at present, cooperate to adopt OHA and keep on a diet, and the treatment diabetes are had effect energetically, but its course of treatment are long, and dosage is big, take for a long time to be prone to develop immunity to drugs, and side effect is big.Chinese traditional treatment should disease medicine more, but effect is not ideal.The long-term control diet just can lack nutrition in the body, immunity degradation, thus accelerated the development of complication, life and health in serious threat.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that can effectively prevent and treat the generation of diabetes, the raw material that it adopted is the Chinese herbal medicine of integration of edible and medicinal herbs, and its therapeutic effect is good; Instant effect; Do not have repeatedly, side effect is little, and medication preparation is easy, low production cost.
Another object of the present invention provides a kind of method for preparing of treating the Chinese herbal medicine of diabetes.
For realizing above-mentioned purpose, pharmaceutical composition of the present invention is the medicament of being processed by the medicine of following weight portion proportioning:
Rhizoma Dioscoreae 5-20 part, Fructus Lycii 10-25 part, Charantin 10-30 part, Radix Puerariae 5-20 part, 1030 parts in Poria, Fructus Mume 10-30 part, Semen Coicis 10-30 part, Fructus Crataegi 15-25 part.
Be preferably: 10 parts of Rhizoma Dioscoreaes, 15 parts of Fructus Lyciis, 20 parts of Charantins, 10 parts of Radix Puerariaes, 20 parts in Poria, 20 parts of Fructus Mumes, 20 parts of Semen Coiciss, 20 parts of Fructus Crataegis.
The biological activity and the natural attribute of above-mentioned prescription raw material have blood sugar lowering; Specific functions such as blood lipid regulation; Both can be used as medicine, also can be used as replenishing of daily bread, health had been played certain regulating action; Raw material also is the composition of integration of edible and medicinal herbs, can cooperate the effect that plays treating both the principal and secondary aspects of a disease.Each compatibility of drugs uses can play synergism, has supplementing QI and nourishing YIN, invigorating QI to consolidate the body surface resistance, and promoting the production of body fluid to quench thirst, liver and kidney tonifying, interior-heat is quenched one's thirst, blood sugar lowering, the effect of blood fat reducing.
The function of each component drug is respectively:
Fructus Mume: [effect and effect]
Convergence is promoted the production of body fluid, the relieving colic caused by ascaris anthelmintic.Control chronic cough, the deficiency-heat excessive thirst, chronic malaria, chronic diarrhea, dysentery is had blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.
Poria: [effect and effect]
Poria property slightly sweet flavor is flat, goes into the heart, lung, spleen channel.Has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can control dysuria, the edema distension, the phlegm retention cough with dyspnea, vomiting, malignant histocytosis is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria reaches through strong activating the spleen pulmonary function, and is different with the medicine of other direct diuretic.
Radix Puerariae: [effect and effect]
The yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is quenched the thirst.Cold, the warm headache stiffness of the nape that cures the wound, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not passed through, hypertension, angina pectoris, deafness.The main effect of Radix Puerariae is expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, and is used for fever and headache, thirsty, symptom such as quench one's thirst.
Rhizoma Dioscoreae: [effect and effect]
Effect: heat clearing away, detoxifcation.Control the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.
Effect:
1. hypoglycemic activity
2. regulate body to non-special IR property effect
3. to Immune Effects
4. have the intestinal motility of stimulation, promote the intestinal contents emptying.
5. other contained nutritional labelings and phlegmatic temperament, amylase are relevant, and tonic effect is arranged, can be aid digestion, antidiarrheal, eliminate the phlegm.
Semen Coicis: [function cures mainly]
Spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease,
Lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.
Fructus Lycii: [function cures mainly]
Cure mainly the hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Fructus Crataegi: [function cures mainly]
Fructus Crataegi has removing food stagnancyization and stagnates, convergence dysentery relieving, effects such as blood circulation promoting and blood stasis dispelling, also scalable blood fat and cholesterol.It contains multivitamin, tartaric acid, citric acid, Crataegolic acid, malic acid etc., also contains mineral such as flavonoid, lactone, saccharide, protein, fat and calcium, ferrum, phosphorus.Contained lipolytic enzyme can promote the digestion of fat food.
Charantin: [function cures mainly]
Clearing away summer-heat, analgesic, the detoxifcation that makes eye bright, the kidney invigorating profit spleen.Dietotherapeutic, nutritious, regulate immunity, prevent diabetes is improved looks.
The preparation of drug combination method that the present invention treats diabetes comprises the steps to process:
(1) screen, clean, dry subsequent use to raw material;
(2) raw material is pressed the prescription actual ratio and is mixed after, it is 100 orders that first coarse pulverization is machined to particle diameter, will pass through the hybrid particles after the coarse pulverization processing again, passes through grinding and processing once more, obtains particle diameter 150-250 purpose fine powder;
Required various conventional adjuvant when (3) fine drug powder processed being added the preparation different dosage form; Like diluent, disintegrating agent, binding agent, lubricant, filler, antiseptic, correctives, stabilizing agent, surfactant etc.; Process any peroral dosage form commonly used with the conventional medicine formulation method, like tablet: dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet; Capsule: soft capsule, microcapsule; Granule; Pill: drop pill; Powder; Oral liquid; Slow releasing preparation; Controlled release preparation etc.
The pharmaceutical composition preferred manufacturing procedure that the present invention treats diabetes comprises the steps to process:
(1) screen, clean, dry subsequent use to raw material;
(2) raw material is pressed the prescription actual ratio and is mixed after, it is 100 orders that first coarse pulverization is machined to particle diameter, will pass through the hybrid particles after the coarse pulverization processing again, passes through grinding and processing once more, obtains particle diameter 150-250 purpose fine powder;
(3) fine drug powder of processing is charged into capsule and can make capsule.
Each raw material proportional mixing of medicine is pulverized to more being prone to behind the 150-250 purpose fine powder and is absorption of human body, and drug effect improves.
In sum, pharmaceutical composition of the present invention can be used for preparing the medicine and the health product of prevention and treatment diabetes, with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage, can fundamentally prevent and treat diabetes.
The specific embodiment
Embodiment 1
The consumption of each component of medicine of the present invention can be: Rhizoma Dioscoreae 10 grams, Fructus Lycii 15 grams, Charantin 20 grams, Radix Puerariae 10 grams, Poria 20 grams, Fructus Mume 20 grams, Semen Coicis 20 grams, Fructus Crataegi 20 grams.Its preparation method is: screen, clean, dry subsequent use to raw material; After raw material pressed the prescription actual ratio and mix, it was 100 orders that first coarse pulverization is machined to particle diameter, will pass through the hybrid particles after the coarse pulverization processing again, passed through grinding and processing once more, obtained particle diameter 150-250 purpose fine powder; The fine drug powder of processing is charged into capsule can make capsule.
Embodiment 2
The consumption of each component of medicine of the present invention can be: Rhizoma Dioscoreae 20 grams, Fructus Lycii 25 grams, Charantin 30 grams, Radix Puerariae 20 grams, Poria 30 grams, Fructus Mume 30 grams, Semen Coicis 30 grams, Fructus Crataegi 25 grams.Its preparation method is: screen, clean, dry subsequent use to raw material; After raw material pressed the prescription actual ratio and mix, it was 80 orders that first coarse pulverization is machined to particle diameter, will pass through the hybrid particles after the coarse pulverization processing again, passed through grinding and processing once more, obtained particle diameter 100-200 purpose fine powder; With the fine drug powder of processing, add binding agent, filler, lubricant, fluidizer, become tablet according to the preparation of pharmaceutical preparation conventional method.
Embodiment 3
The consumption of each component of medicine of the present invention can be: Rhizoma Dioscoreae 5 grams, Fructus Lycii 10 grams, Charantin 10 grams, Radix Puerariae 5 grams, Poria 10 grams, Fructus Mume 10 grams, Semen Coicis 10 grams, Fructus Crataegi 15 grams.Its preparation method becomes capsule according to embodiment 1 preparation.
Embodiment 4
The consumption of each component of medicine of the present invention can be: Rhizoma Dioscoreae 15 grams, Fructus Lycii 15 grams, Charantin 20 grams, Radix Puerariae 15 grams, Poria 25 grams, Fructus Mume 25 grams, Semen Coicis 25 grams, Fructus Crataegi 25 grams.Its preparation method becomes tablet according to embodiment 2 preparations.
Therapeutic effect: the present invention treats the medicine of diabetes, through clinical application for many years 190 routine patients, 53.6 years old mean age.
Diagnostic criteria: polyuria is often arranged, polydipsia, polyphagia is become thin, and is tired, and To Be Protected from Heat, and happiness is cool, dispute dry pharynx, yellowish urine dry stool, red tongue pregnant jaundice, rapid pulse.Blood glucose, GH, glucose in urine are higher, and blood fat is higher.
Therapeutic Method: take the medication medication of the embodiment of the invention 1 and 3, oral every day 3 times, each 2-3 grain; Or take the medicine of the embodiment of the invention 2 and 4, oral every day 3 times, each 2-3 sheet.
Curative effect determinate standard: 1) produce effects, clinical symptom disappearance, sign are obviously improved; Fasting glucose and 2 hours after the meal blood glucose drop to normal range.2) effective, clinical symptoms obviously alleviates, sign all take a favorable turn; Fasting glucose and 2 hours after the meal blood glucose descend above 20% before the treatment.3) invalid, each item index does not reach the above-mentioned requirements standard.
The result: cure 159 examples, 28 examples that take a turn for the better, invalid 3 examples, effective percentage reaches more than 98%.
Experiment case 1:
Hebei patient Liu: the man, 48 years old, type 2 diabetes mellitus, medical history 5 years is taken the medication medication of treating diabetes, not insulin injection for a long time.Finding the ill initial stage often with tired mind, soreness of the waist and knees, symptom such as thirsty, and immunity is low, is prone to suffer from influenza; Blood glucose between 10-15, take some medicines after, blood glucose is controlled to some extent, but often repeatedly, begins to take medicine of the present invention the year before; Consumption is every day three times, and each 2, it is remarkable to take after one month effect, and blood glucose obviously descends; Be controlled between the 7-9, after change every day three times into, each 1, took again 3 months; Blood glucose is still controlled well, does not phase down consumption under repeatedly the prerequisite through measuring at blood glucose, has taken 1 every day now, and blood glucose remains between the 5.26.4 basically; The mental status also is greatly improved than before, and sleep is good, feels relief from head to foot, still adheres at present taking.
Experiment case 2:
Patient Shen, Hubei: find oneself to have suffered from diabetes in February, 2,006 52 years old this year, and fasting glucose 18 at that time.Mainly come blood sugar control by metformin in before in the December, 2008, metformin progressively is increased to 2 1.0 content from 1 0.5 content of every meal.But blood glucose is lost control of, fasting glucose about 9.Begin to take medicine of the present invention in 2009, take 3 after the meal, and detect blood glucose 4-6 time every day, begin after the 4th day to cancel whole metformin, gradually reduce 6,5,4,2,1 of the capsular consumption of the present invention every day.In December, 2009 begins 1 after the meal, and three of every days, blood sugar recovery is normal after half a year.
Experiment case 3:
Jiangsu patient Lee man suffered from type 2 diabetes mellitus so far in 62,2007 years, and originally fasting glucose 9.1; Beat insulin 25 ante cibum, blood glucose 14 after meal, because work relationship; So three meals are unpunctual yet, glycemic control is bad, once even ketoacidosis; Threaten life, the household and but the heart rush about and seek medical advice.After began to take capsule of the present invention 1 year, the blood glucose basic controlling is in ante cibum 6, after meal about 8, complication also improves.
Experiment case 4:
Tianjin season, man, 57 years old.Find diabetes in May, 2005, begins to take Western medicine and don't work.Do the gallbladder excising operation more afterwards, beat insulin in 2005 to 2007, ate health product in 2008.On March 18th, 2009 began to eat medicine of the present invention, surveyed blood glucose 15.3 before the meal before eating.Early eating 2, noon eats 2, evening and eats 1.Beginning blood glucose is in 12.5 fluctuations up and down.From eat every day May 1 in 09 year three times each 2, blood glucose survey in morning on every Saturdays now once, fasting glucose is between 6.2 and 6.6.Blood glucose is relatively stable, and somatosensory is good.
Claims (4)
1. pharmaceutical composition that is used to treat diabetes, it is characterized in that: it is the medicament of being processed by the medicine of following weight portion proportioning: Rhizoma Dioscoreae 5-20 part, Fructus Lycii 10-25 part, Charantin 10-30 part, Radix Puerariae 5-20 part, Poria 10-30 part, Fructus Mume 10-30 part, Semen Coicis 10-30 part, Fructus Crataegi 15-25 part.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that: it is the medicament of being processed by the medicine of following weight portion proportioning: 10 parts of Rhizoma Dioscoreaes, 15 parts of Fructus Lyciis, 20 parts of Charantins, 10 parts of Radix Puerariaes, 20 parts in Poria, 20 parts of Fructus Mumes, 20 parts of Semen Coiciss, 20 parts of Fructus Crataegis.
3. pharmaceutical composition as claimed in claim 1, it is characterized in that: described medicament is said any medicament on the pharmaceutics, is preferably capsule.
4. one kind like the described preparation of drug combination method that is used to treat diabetes of one of claim 1-3, and it is characterized in that: it comprises the steps to process:
(1) screen, clean, dry subsequent use to raw material;
(2) raw material is pressed the prescription actual ratio and is mixed after, it is 100 orders that first coarse pulverization is machined to particle diameter, will pass through the hybrid particles after the coarse pulverization processing again, passes through grinding and processing once more, obtains particle diameter 150-250 purpose fine powder;
(3) fine drug powder of processing being charged into capsule gets final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103156244A (en) * | 2013-03-03 | 2013-06-19 | 王凯莹 | Edible drink for diabetic patients and preparation method thereof |
| CN104922537A (en) * | 2015-06-08 | 2015-09-23 | 柳州市宝杨种植专业合作社 | Traditional Chinese medicinal drink formula using dendrobium officinale as lead medicine |
| CN114931613A (en) * | 2022-04-01 | 2022-08-23 | 山西振东五和医养堂股份有限公司 | Tea substitute beverage with blood pressure lowering effect and preparation method and application thereof |
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| CN101632769A (en) * | 2008-07-25 | 2010-01-27 | 河北以岭医药研究院有限公司 | Chinese medicinal composition for regulating blood sugar and preparation method thereof |
| CN101708295A (en) * | 2009-12-04 | 2010-05-19 | 卢速江 | Chinese medicinal preparation for treating diabetes and preparation methods thereof |
| CN101773624A (en) * | 2010-02-09 | 2010-07-14 | 陈秋生 | Traditional Chinese medicine composition for curing diabetes and preparation method thereof |
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2012
- 2012-01-18 CN CN2012100147685A patent/CN102552743A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101632769A (en) * | 2008-07-25 | 2010-01-27 | 河北以岭医药研究院有限公司 | Chinese medicinal composition for regulating blood sugar and preparation method thereof |
| CN101708295A (en) * | 2009-12-04 | 2010-05-19 | 卢速江 | Chinese medicinal preparation for treating diabetes and preparation methods thereof |
| CN101773624A (en) * | 2010-02-09 | 2010-07-14 | 陈秋生 | Traditional Chinese medicine composition for curing diabetes and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 侣丽萍: ""动-定序贯八法"临证辨治消渴病", 《中国博士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103156244A (en) * | 2013-03-03 | 2013-06-19 | 王凯莹 | Edible drink for diabetic patients and preparation method thereof |
| CN104922537A (en) * | 2015-06-08 | 2015-09-23 | 柳州市宝杨种植专业合作社 | Traditional Chinese medicinal drink formula using dendrobium officinale as lead medicine |
| CN114931613A (en) * | 2022-04-01 | 2022-08-23 | 山西振东五和医养堂股份有限公司 | Tea substitute beverage with blood pressure lowering effect and preparation method and application thereof |
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Addressee: Xu Yazhen Document name: Notification of Publication of the Application for Invention |
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Address after: 100022, building 1002, building D33, Fuli Town, Chaoyang District, Beijing, Shuangjing Applicant after: Xu Yazhen Address before: 100090 Beijing city Chaoyang District huaweili Yijingjiayuan building 26B Applicant before: Xu Yazhen |
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