CN104906547A - Medicinal granules for treating spleen-qi deficiency type diarrhea associated with menstruation and preparation method of medicinal granules - Google Patents

Abstract

The invention discloses medicinal granules for treating spleen-qi deficiency type diarrhea associated with menstruation. The traditional Chinese medicine components of the medicinal granules consist of the following raw medicinal materials in parts by weight: 15-33 parts of ginseng, 10-30 parts of herb of rose glorybind, 15-25 parts of rhizome of tendrilleaf solomonseal, 20-40 parts of largehead atractylodes rhizome, 10-25 parts of glossy privet fruit, 10-20 parts of common hawksbeard, 8-16 parts of tuner onion seed, 10-20 parts of black sesame, 6-12 parts of elsholtzia rugulosa, 10-20 parts of licorice root, 6-16 parts of engelhardia roxburghiana, 8-16 parts of cardamom, 6-12 parts of chalk, 8-16 parts of dark plum fruit, 6-14 parts of pomegranate rind, 6-16 parts of dried ginger, 6-14 parts of flower of hyacinth dolichos, 8-16 parts of Chinese date, 8-16 parts of rock candy and 6-14 parts of rhizome of swordlike atractylodes. The medicinal granules disclosed by the invention are clear and definite in curative effect on the spleen-qi deficiency type diarrhea associated with menstruation and strong in symptomatic treatment effect, and are specially used for treating special diseases, and active ingredients in the medicinal granules can be quickly absorbed, so that the medicinal granules are quick and effect and have very good effect of conditioning bodies.

Description

A kind ofly treat electuary of insufficiency of spleen-qi type diarrhea during menstruation and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, be specifically related to a kind ofly treat electuary of insufficiency of spleen-qi type diarrhea during menstruation and preparation method thereof.

Background technology

Diarrhea during menstruation, refers to menstrual period or before and after passing through, periodically occurs loose stool and diarrhea, day line number time be the menstrual phase disease of main manifestations, be called " diarrhea during menstruation ", also known as " through having loose bowels ".Be mainly in women's menstrual period.Principal pathogenetic mechanism is spleen kidney yang QI-insufficiency, transporting mistake department, and value vim and vigour in menstrual period bet punching is appointed, and spleen kidney is more empty and have loose bowels.Common typing has stagnation of liver-QI with deficiency of the spleen, kidney yang virtual loss and liver-yang hyperactivity spleen weak.

1. deficiency-weakness of spleen-QI: ferritic is insufficiency of the spleen, or melancholy,anxiety and overstrain, eating and drinking without temperance.Temper is impaired, when row, QI and blood bet punching appoint, temper is more empty, transporting mistake department, therefore retention of water-damp in the body, under walk large intestine, then cause and have loose bowels.

2. kidney yang virtual loss: element is reported and suffered from a deficiency of the kidney, or exhaustion due to sexual indulgence fecund, decline of the fire from the gate of life, when row, QI and blood bet punching is appointed, and life fire more declines, and can not go up temperature in spleen, dysfunction of the spleen in transportation, then causes and have loose bowels.

3. liver-yang hyperactivity spleen is weak: liver storing blood, its property happiness free flow of qi, and as because of depression of liver-QI, stagnation of liver-QI perverse and unreasonable manner, restrain temper, then transporting is weak, and the empty ice temperature of temper benefit is dirty, also can cause diarrhea during menstruation.

Clinical treatment diarrhea during menstruation is comparatively thorny, and treat this disease and mainly adopt the Quick stopping leak medicine treatments such as hormones, side effect is large, cures the symptoms, not the disease, therefore extensive patients need badly a kind of can treating both the principal and secondary aspects of a disease, the medicine that has no side effect to be to treat diarrhea during menstruation.

Summary of the invention

The object of this invention is to provide and a kind ofly treat electuary of insufficiency of spleen-qi type diarrhea during menstruation and preparation method thereof, electuary of the present invention is to insufficiency of spleen-qi type diarrhea during menstruation clear curative effect, suiting the medicine to the illness property is strong, Special Nursing in Special Disease is controlled, and effective ingredient wherein can arrive lesions position fast, absorbed rapidly, fast effectively, to health, be there is good opsonic action.

To achieve these goals, technical scheme provided by the invention is:

Treat an electuary for insufficiency of spleen-qi type diarrhea during menstruation, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 15-35 part, DAWANHUA 10-30 part, Rhizoma Polygonati Cirrhifolii 15-25 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Fructus Ligustri Lucidi 10-25 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 10-20 part, Semen Allii Tuberosi 8-16 part, Semen Sesami Nigrum 10-20 part, Elsholtzia regulosa 6-12 part, Radix Glycyrrhizae 10-20 part, Engelhardtia roxburghiana 6-16 part, Fructus Amomi Rotundus 8-16 part, Chalk 6-12 part, Fructus Mume 8-16 part, Pericarpium Granati 6-14 part, Rhizoma Zingiberis 6-16 part, Flos dolichoris 6-14 part, Fructus Jujubae 8-16 part, SHIMI 8-16 part, Rhizoma Atractylodis 6-14 part.

Further, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 20-30 part, DAWANHUA 15-25 part, Rhizoma Polygonati Cirrhifolii 18-22 part, Rhizoma Atractylodis Macrocephalae 25-35 part, Fructus Ligustri Lucidi 14-21 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 12-18 part, Semen Allii Tuberosi 10-14 part, Semen Sesami Nigrum 12-18 part, Elsholtzia regulosa 8-10 part, Radix Glycyrrhizae 12-18 part, Engelhardtia roxburghiana 8-14 part, Fructus Amomi Rotundus 10-14 part, Chalk 8-10 part, Fructus Mume 10-14 part, Pericarpium Granati 8-12 part, Rhizoma Zingiberis 8-14 part, Flos dolichoris 8-12 part, Fructus Jujubae 10-14 part, SHIMI 10-14 part, Rhizoma Atractylodis 8-12 part.

Further, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 25 parts, DAWANHUA 20 parts, Rhizoma Polygonati Cirrhifolii 20 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Fructus Ligustri Lucidi 18 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 15 parts, Semen Allii Tuberosi 12 parts, Semen Sesami Nigrum 15 parts, Elsholtzia regulosa 9 parts, 15 parts, Radix Glycyrrhizae, Engelhardtia roxburghiana 11 parts, 12 parts, Fructus Amomi Rotundus, Chalk 9 parts, Fructus Mume 12 parts, Pericarpium Granati 10 parts, Rhizoma Zingiberis 11 parts, Flos dolichoris 10 parts, 12 parts, Fructus Jujubae, SHIMI 12 parts, Rhizoma Atractylodis 10 parts.

The present invention also provides a kind of preparation method for the treatment of the electuary of insufficiency of spleen-qi type diarrhea during menstruation, comprises the following steps:

(1) Radix Ginseng, DAWANHUA, Rhizoma Polygonati Cirrhifolii, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Semen Allii Tuberosi, Semen Sesami Nigrum, Elsholtzia regulosa, Radix Glycyrrhizae, Engelhardtia roxburghiana, Fructus Amomi Rotundus, Chalk, Pericarpium Granati, Rhizoma Zingiberis, Flos dolichoris, Rhizoma Atractylodis are ground to 50 orders, add the 4-6 ethanol doubly of above-mentioned Chinese drugs powder, then reflux, extract, 2-3h is carried out, collect extracting solution and filtering residue, reclaim ethanol, filtering residue is added 3-5 times of soak by water 1-2h, collect filtrate, merge twice filtrate;

(2) filtrate obtained for step (1) mixed with the SHIMI of 1/2 quality and stir, mixed liquor being carried out spraying dry, and crosses 80 mesh sieves, obtain mixing Chinese medicinal powder;

(3) SHIMI of residue 1/2 quality is pulverized and Fructus Mume, the little fiery parch of Fructus Jujubae, then grind into powder and cross 80 mesh sieves, obtain mixing Fructus Mume powder;

(4) by the mixing Fructus Mume powder mix homogeneously that mixing Chinese medicinal powder obtained for step (2), step (3) obtain, the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation is obtained.

Using method: oral, each twice, sooner or later respectively once, each 10g, warm water is taken after washing open.

Pharmacological action:

Radix Ginseng: sweet in the mouth, micro-hardship is warm in nature, flat.Return spleen, lung meridian, heart channel.Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.Main weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hyperhidrosis, lack of appetite is unable, all acute and chronic diseases and the shock caused after losing blood, collapse; DAWANHUA: be Convolvulaceae calystegia plant DAWANHUA, be used as medicine with root stock.Sweet, light, flat.Invigorating the spleen and benefiting QI, diuresis, regulating menstruation, leukorrhagia stopping; For insufficiency of the spleen dyspepsia, menoxenia, leucorrhea, milk is rare; Rhizoma Polygonati Cirrhifolii: Gan Xin is flat." Shaanxi Chinese herbal medicine ": sweet in the mouth is micro-pungent, warm in nature, slightly poisonous.Nourishing lung-YIN, invigorating the spleen and benefiting QI, hemostasis of eliminating the phlegm, subduing swelling and detoxicating.Control chronic consumptive disease cough, dizzy, lack of appetite, seminal emission, night sweat, bleeding not during menses, puerperal, body lost, and spitted blood, epistaxis, traumatic hemorrhage, laryngopharynx swelling and pain, and skin ulcer swells, scrofula; The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.Avoid Fructus Persicae, Lee, Plantula Brassicae chinensis, Passeris montani saturati meat, Mylopharyngodon piceus; Fructus Ligustri Lucidi: sweet, bitter, cold.Return liver, kidney channel.Liver and kidney tonifying, improving eyesight, clearind deficient heat.Cure mainly and have a dizzy spell, early whitening of beard and hair, blurring of vision, fever due to yin deficiency.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect; Crepis crocea Babc.(C.turczaninowii C.A.Mey.): " Yunnan Chinese herbal medicine ": " bitter, temperature." liver and kidney tonifying, invigorating spleen to remove dampness.Master has a dizzy spell, soreness of the waist and knees, edema, leukorrhagia infantile malnutrition, hypogalactia." Yunnan Chinese herbal medicine ": " invigorating the liver and kidney, strengthening the spleen increases breast.Control infantile malnutrition, anemia, leucorrhea, edema, hepatitis, hypogalactia, traumatic injury, discharging fresh blood stool." " Kunming conventional medical herbs among the people ": " tonify deficiency, strong Liver and kidney.Control dizzy body empty, myasthenia of limbs, milk is few, blurred vision, bones and muscles pain."; Semen Allii Tuberosi: pungent, sweet, warm.Return liver, kidney channel.Liver and kidney tonifying, tonifying YANG controlling nocturnal emission with astringent drugs.Main impotence due to deficiency of the kidney, soreness of the waist and knees, seminal emission, frequent micturition, turbid urine, leukorrhagia are rare clearly; Semen Sesami Nigrum: sweet, flat.Return liver, kidney, large intestine channel.Invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation; Elsholtzia regulosa: acrid in the mouth, hardship, cool in nature.Induce sweat bring down a fever, removing dampness for regulating stomach.Main cold, fever, headache, vomiting are had loose bowels, dysentery, rotten skin ulcer, epistaxis hemoptysis, traumatic hemorrhage." choosing of Yunnan Chinese herbal medicine ": heat-clearing and toxic substances removing, promoting digestion and removing stagnation.Control Common Cold.Dyspepsia, abdominal pain and distension; Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong; Engelhardtia roxburghiana: medicinal part is bark.Bark: micro-hardship, pungent is flat.Circulation of qi promoting, removing dampness, intestinal stasis relieving.Cure mainly taste humidity hysteresis, breast abdominal distention is vexed, diarrhea due to damp-heat; Fructus Amomi Rotundus: medicinal part be plant be dried to who fruit.Acrid in the mouth, warm in nature.Return lung, spleen, stomach warp.Removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, appetite-stimulating indigestion-relieving.For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear; Chalk: bitter, temperature.Nontoxic." book on Chinese herbal medicine is new again ": " enter lung, kidney two warp." warming middle-JIAO, astringing intestine to stop diarrhea, hemostasis, sore.Control regurgitation, dysentery, spit blood, epistaxis, marginal blepharitis, ecthyma; Fructus Mume: medicinal part is dry almost ripe fruit.Sour in the mouth, puckery, property is put down.Return liver, spleen, lung, large intestine channel.Astringe the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic diarrhea chronic dysentery, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache; Pericarpium Granati: medicinal part is dry peel.Sour in the mouth, puckery, warm in nature.Return large intestine channel.Relieving diarrhea with astringents, hemostasis, anthelmintic.For chronic diarrhea, chronic dysentery, has blood in stool, proctoptosis, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation; Rhizoma Zingiberis: medicinal part is the dry rhizome of plant.Acrid in the mouth, hot in nature.Return spleen, stomach, kidney, the heart, lung meridian.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention.For coldness and pain in the epigastrium, vomiting is had loose bowels, cold extremities faint pulse, and cold fluid-retention is breathed with cough; Fructus Jujubae: Fructus Jujubae: sweet in the mouth, warm in nature, nontoxic.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Prevention transfusion reaction, reduces serum glutamic pyruvic transminase, antitumor, antioxidation, blood pressure lowering, cholesterol reducing, hepatoprotective, improves immunity, control cerebral blood supply insufficiency, antiallergic, and anti-angiocardiopathy, prevents and treats osteoporosis and anemia; SHIMI: SHIMI refers to the original sucrose of the solid of Caulis Sacchari sinensis juice after the sun is exposed to the sun.Sweet, flat, nontoxic.There is moistening the lung and resolving phlegm, control and allly to cough, have special effect by the five internal organs deficiency, invigorating the stomach and promoting digestion, stomachache, gastropathy duodenal ulcer, analgesic antidotal, class outer rheumatic arthritis, anemia, gynaecopathia etc.Energy and hundred medicines are supported temper except many diseases and are removed vexed.Clothes of a specified duration can strong will be made light of one's life by commiting suicide, and not hungry old, appearance, skin care is made us gloss, looked like Flos Carthami, is ill curing the disease, without the fabulous good merchantable brand for the treatment of diseases and making health-care; Flos dolichoris: containing the composition such as protein, vitamin.Flat, sweet light, nontoxic.Return spleen, stomach, large intestine channel.Have spleen invigorating and in, expelling summer-heat and damp, antidiarrheal, the effects such as leukorrhagia stopping.Can be used for heat-damp in summer to vomit and diarrhoea, insufficiency of the spleen vomiting, lack of appetite chronic diarrhea, leucorrhea with red and white discharge, water retention is quenched one's thirst, dysentery, the diseases such as infantile malnutrition; Rhizoma Atractylodis: medicinal part is the dry rhizome of plant.Acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For retention of dampness in middle-JIAO, distension and fullness in the abdomen, has loose bowels, edema, and beriberi flaccidity is knitted, and rheumatic arthralgia, anemofrigid cold, nyctalopia, eyes dusk is puckery.

Theory of Chinese medical science is thought, temper deficiency in origin, and QI and blood was noted and appointed in punching premenstrual or menstrual period, and temper is more empty, transformation failure of spleen, walked large intestine, therefore made to have loose bowels, distension and fullness in the abdomen under water is wet; Spleen governing limbs, deficiency-weakness of spleen-QI, therefore fatigue in both spirit and physical strength; The wet skin that overflows of water, therefore puffiness of the face and limbs; Deficiency of spleen-QI loses in having under one's command, the debility of CHONG and REN meridians.Therefore many through row amount, the light matter of color is rare; Insufficiency of the spleen resulting in production of dampness, damp flowing downward to lower-JIAO, damage dai channel, dai channel is failed to keep an appointment, therefore profuse leukorrhea, color white matter is glued.Light red tongue is fat, and tongue is greasy in vain, relaxed and soft pulse, levying also for deficiency of spleen-QI.

Based on above-mentioned theory of Chinese medical science, the present invention with invigorating the spleen and benefiting QI, liver and kidney tonifying, removing dampness for regulating stomach, relieving diarrhea with astringents for Therapeutic Principle.Temper deficiency in origin, QI and blood was noted and was appointed in punching premenstrual or menstrual period, and temper is more empty, transformation failure of spleen, walks large intestine under water is wet, therefore makes to have loose bowels, distension and fullness in the abdomen, so in side with the medicine of Radix Ginseng, DAWANHUA, Rhizoma Polygonati Cirrhifolii, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI for monarch drug, wherein admittedly de-, the invigorating the spleen to benefit the lung of Radix Ginseng strongly invigorating primordial QI, multiple arteries and veins, DAWANHUA invigorating the spleen and benefiting QI, Rhizoma Polygonati Cirrhifolii nourishing lung-YIN, invigorating the spleen and benefiting QI, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic, this four Chinese medicine shares energy invigorating the spleen and benefiting QI, fundamentally enriching spleen-QI; Fructus Ligustri Lucidi, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Semen Allii Tuberosi, Semen Sesami Nigrum are ministerial drug altogether, Fructus Ligustri Lucidi liver and kidney tonifying, improving eyesight, clearind deficient heat, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) liver and kidney tonifying, invigorating spleen to remove dampness, Semen Allii Tuberosi liver and kidney tonifying, tonifying YANG controlling nocturnal emission with astringent drugs, Semen Sesami Nigrum invigorating the liver and kidney, benefiting essence-blood, intestine moistening are dry, and this four Chinese medicine shares can liver and kidney tonifying, invigorating spleen to remove dampness; Elsholtzia regulosa, Radix Glycyrrhizae, Engelhardtia roxburghiana, Fructus Amomi Rotundus, Chalk, Fructus Mume, Pericarpium Granati, Rhizoma Zingiberis, Flos dolichoris are adjuvant drug altogether, wherein Elsholtzia regulosa induce sweat bring down a fever, removing dampness for regulating stomach, Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, Engelhardtia roxburghiana circulation of qi promoting, removing dampness, intestinal stasis relieving.Cure mainly taste humidity hysteresis, breast abdominal distention is vexed, diarrhea due to damp-heat, Fructus Amomi Rotundus removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, appetite-stimulating indigestion-relieving, Chalk warming middle-JIAO astringing intestine to stop diarrhea, Fructus Mume is astringed the lung, astringing intestine to stop diarrhea, Pericarpium Granati relieving diarrhea with astringents, Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, and this few taste medicine can reach effect of removing dampness for regulating stomach, relieving diarrhea with astringents, the distension and fullness in the abdomen caused for deficiency of spleen-QI, fatigue in both spirit and physical strength, water wet overflow skin, puffiness of the face and limbs, play effect of removing dampness circulation of qi promoting, appetite-stimulating indigestion-relieving, relieving diarrhea with astringents; More with the addition of Flos dolichoris, Fructus Jujubae, SHIMI, Rhizoma Atractylodis altogether for making medicine, wherein Flos dolichoris have spleen invigorating and in, expelling summer-heat and damp, antidiarrheal, the effects such as leukorrhagia stopping, the invigorating the spleen and replenishing QI of Fructus Jujubae energy, nourishing blood to tranquillize the mind, SHIMI energy and hundred medicines are except many sick foster temper, SHIMI coordinates coordinating the actions of various ingredients in a prescription effect better with Radix Glycyrrhizae, Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, and Rhizoma Atractylodis coordinate with Flos dolichoris and can enter spleen by priming, make medicine fast onset drug effect, help the dampness of all medicine invigorating the spleen and benefiting QI, a good appetite suddenly appearing in a serious disease Jiao, reason taste are with antidiarrheal.

In preparation method of the present invention, SHIMI is pulverized and carries out grinding to be used as medicine after frying with Fructus Mume, the little fire of Fructus Jujubae, some carbonization of epidermis after frying, the structure of this part carbonization enters human body by digestive tract can adsorb harmful substance in human body, plays the effect of toxin expelling.

The invention has the beneficial effects as follows:

(1) the present invention is under Traditional Chinese medical theory and clinical experience instruct, selected medicament composing prescription meets theory of Chinese medical science and Pharmacopoeia of People's Republic of China requirement, to human non-toxic's side effect, all former spices are coordinated gram at utmost to play drug effect according to the principle of monarch together, play the merit of warming the kidney to activate YANG, invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, dehumidifying antidiarrheal altogether, reach the object for the treatment of insufficiency of spleen-qi type diarrhea during menstruation;

(2) the present invention is prepared into dissolved granule, and adds Flos dolichoris, Rhizoma Atractylodis, can enter spleen by priming, and energy fast onset drug effect, helps the dampness of all medicine invigorating the spleen and benefiting QI, a good appetite suddenly appearing in a serious disease Jiao, and reason taste are with antidiarrheal;

(3) electuary of the present invention determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs in treatment, for insufficiency of spleen-qi type diarrhea during menstruation clear curative effect, suiting the medicine to the illness property is strong, and Special Nursing in Special Disease is controlled, and treating both the principal and secondary aspects of a disease, there is good opsonic action to health.

Detailed description of the invention

Below in conjunction with embodiments of the invention, technical scheme of the present invention is clearly and completely described.

Embodiment 1

A kind of electuary for the treatment of insufficiency of spleen-qi type diarrhea during menstruation, it is characterized in that, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 15 parts, DAWANHUA 10 parts, Rhizoma Polygonati Cirrhifolii 15 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Ligustri Lucidi 10 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 10 parts, Semen Allii Tuberosi 8 parts, Semen Sesami Nigrum 10 parts, Elsholtzia regulosa 6 parts, 10 parts, Radix Glycyrrhizae, Engelhardtia roxburghiana 6 parts, 8 parts, Fructus Amomi Rotundus, Chalk 6 parts, Fructus Mume 8 parts, Pericarpium Granati 6 parts, Rhizoma Zingiberis 6 parts, Flos dolichoris 6 parts, 8 parts, Fructus Jujubae, SHIMI 8 parts, Rhizoma Atractylodis 6 parts.

The preparation method of the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation comprises the following steps:

(1) Radix Ginseng, DAWANHUA, Rhizoma Polygonati Cirrhifolii, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Semen Allii Tuberosi, Semen Sesami Nigrum, Elsholtzia regulosa, Radix Glycyrrhizae, Engelhardtia roxburghiana, Fructus Amomi Rotundus, Chalk, Pericarpium Granati, Rhizoma Zingiberis, Flos dolichoris, Rhizoma Atractylodis are ground to 50 orders, add the ethanol of 4 times of above-mentioned Chinese drugs powder, then reflux, extract, 2h is carried out, collect extracting solution and filtering residue, reclaim ethanol, filtering residue is added 3 times of soak by water 1h, collect filtrate, merge twice filtrate;

(2) filtrate obtained for step (1) mixed with the SHIMI of 1/2 quality and stir, mixed liquor being carried out spraying dry, and crosses 80 mesh sieves, obtain mixing Chinese medicinal powder;

(3) SHIMI of residue 1/2 quality is pulverized and Fructus Mume, the little fiery parch of Fructus Jujubae, then grind into powder and cross 80 mesh sieves, obtain mixing Fructus Mume powder;

(4) by the mixing Fructus Mume powder mix homogeneously that mixing Chinese medicinal powder obtained for step (2), step (3) obtain, the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation is obtained.

Embodiment 2

A kind of electuary for the treatment of insufficiency of spleen-qi type diarrhea during menstruation, it is characterized in that, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 35 parts, DAWANHUA 30 parts, Rhizoma Polygonati Cirrhifolii 25 parts, the Rhizoma Atractylodis Macrocephalae 40 parts, Fructus Ligustri Lucidi 25 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 20 parts, Semen Allii Tuberosi 16 parts, Semen Sesami Nigrum 20 parts, Elsholtzia regulosa 12 parts, 20 parts, Radix Glycyrrhizae, Engelhardtia roxburghiana 16 parts, 16 parts, Fructus Amomi Rotundus, Chalk 12 parts, Fructus Mume 16 parts, Pericarpium Granati 14 parts, Rhizoma Zingiberis 16 parts, Flos dolichoris 14 parts, 16 parts, Fructus Jujubae, SHIMI 16 parts, Rhizoma Atractylodis 14 parts.

The preparation method of the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation comprises the following steps:

(1) Radix Ginseng, DAWANHUA, Rhizoma Polygonati Cirrhifolii, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Semen Allii Tuberosi, Semen Sesami Nigrum, Elsholtzia regulosa, Radix Glycyrrhizae, Engelhardtia roxburghiana, Fructus Amomi Rotundus, Chalk, Pericarpium Granati, Rhizoma Zingiberis, Flos dolichoris, Rhizoma Atractylodis are ground to 50 orders, add the ethanol of 6 times of above-mentioned Chinese drugs powder, then reflux, extract, 3h is carried out, collect extracting solution and filtering residue, reclaim ethanol, filtering residue is added 5 times of soak by water 2h, collect filtrate, merge twice filtrate;

(2) filtrate obtained for step (1) mixed with the SHIMI of 1/2 quality and stir, mixed liquor being carried out spraying dry, and crosses 80 mesh sieves, obtain mixing Chinese medicinal powder;

(3) SHIMI of residue 1/2 quality is pulverized and Fructus Mume, the little fiery parch of Fructus Jujubae, then grind into powder and cross 80 mesh sieves, obtain mixing Fructus Mume powder;

(4) by the mixing Fructus Mume powder mix homogeneously that mixing Chinese medicinal powder obtained for step (2), step (3) obtain, the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation is obtained.

Embodiment 3

Treat an electuary for insufficiency of spleen-qi type diarrhea during menstruation, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 20 parts, DAWANHUA 15 parts, Rhizoma Polygonati Cirrhifolii 18 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Fructus Ligustri Lucidi 14 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 12 parts, Semen Allii Tuberosi 10 parts, Semen Sesami Nigrum 12 parts, Elsholtzia regulosa 8 parts, 12 parts, Radix Glycyrrhizae, Engelhardtia roxburghiana 8 parts, 10 parts, Fructus Amomi Rotundus, Chalk 8 parts, Fructus Mume 10 parts, Pericarpium Granati 8 parts, Rhizoma Zingiberis 8 parts, Flos dolichoris 8 parts, 10 parts, Fructus Jujubae, SHIMI 10 parts, Rhizoma Atractylodis 8 parts.

The preparation method of the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation comprises the following steps:

(1) Radix Ginseng, DAWANHUA, Rhizoma Polygonati Cirrhifolii, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Semen Allii Tuberosi, Semen Sesami Nigrum, Elsholtzia regulosa, Radix Glycyrrhizae, Engelhardtia roxburghiana, Fructus Amomi Rotundus, Chalk, Pericarpium Granati, Rhizoma Zingiberis, Flos dolichoris, Rhizoma Atractylodis are ground to 50 orders, add the ethanol of 5 times of above-mentioned Chinese drugs powder, then reflux, extract, 2h is carried out, collect extracting solution and filtering residue, reclaim ethanol, filtering residue is added 4 times of soak by water 1h, collect filtrate, merge twice filtrate;

(2) filtrate obtained for step (1) mixed with the SHIMI of 1/2 quality and stir, mixed liquor being carried out spraying dry, and crosses 80 mesh sieves, obtain mixing Chinese medicinal powder;

(3) SHIMI of residue 1/2 quality is pulverized and Fructus Mume, the little fiery parch of Fructus Jujubae, then grind into powder and cross 80 mesh sieves, obtain mixing Fructus Mume powder;

(4) by the mixing Fructus Mume powder mix homogeneously that mixing Chinese medicinal powder obtained for step (2), step (3) obtain, the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation is obtained.

Embodiment 4

Treat an electuary for insufficiency of spleen-qi type diarrhea during menstruation, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 30 parts, DAWANHUA 25 parts, Rhizoma Polygonati Cirrhifolii 22 parts, the Rhizoma Atractylodis Macrocephalae 35 parts, Fructus Ligustri Lucidi 21 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 18 parts, Semen Allii Tuberosi 14 parts, Semen Sesami Nigrum 18 parts, Elsholtzia regulosa 10 parts, 18 parts, Radix Glycyrrhizae, Engelhardtia roxburghiana 14 parts, 14 parts, Fructus Amomi Rotundus, Chalk 10 parts, Fructus Mume 14 parts, Pericarpium Granati 12 parts, Rhizoma Zingiberis 14 parts, Flos dolichoris 12 parts, 14 parts, Fructus Jujubae, SHIMI 14 parts, Rhizoma Atractylodis 12 parts.

The preparation method of the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation comprises the following steps:

(1) Radix Ginseng, DAWANHUA, Rhizoma Polygonati Cirrhifolii, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Semen Allii Tuberosi, Semen Sesami Nigrum, Elsholtzia regulosa, Radix Glycyrrhizae, Engelhardtia roxburghiana, Fructus Amomi Rotundus, Chalk, Pericarpium Granati, Rhizoma Zingiberis, Flos dolichoris, Rhizoma Atractylodis are ground to 50 orders, add the ethanol of 6 times of above-mentioned Chinese drugs powder, then reflux, extract, 2h is carried out, collect extracting solution and filtering residue, reclaim ethanol, filtering residue is added 5 times of soak by water 2h, collect filtrate, merge twice filtrate;

(2) filtrate obtained for step (1) mixed with the SHIMI of 1/2 quality and stir, mixed liquor being carried out spraying dry, and crosses 80 mesh sieves, obtain mixing Chinese medicinal powder;

(3) SHIMI of residue 1/2 quality is pulverized and Fructus Mume, the little fiery parch of Fructus Jujubae, then grind into powder and cross 80 mesh sieves, obtain mixing Fructus Mume powder;

(4) by the mixing Fructus Mume powder mix homogeneously that mixing Chinese medicinal powder obtained for step (2), step (3) obtain, the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation is obtained.

Embodiment 5

Treat an electuary for insufficiency of spleen-qi type diarrhea during menstruation, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 25 parts, DAWANHUA 20 parts, Rhizoma Polygonati Cirrhifolii 20 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Fructus Ligustri Lucidi 18 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 15 parts, Semen Allii Tuberosi 12 parts, Semen Sesami Nigrum 15 parts, Elsholtzia regulosa 9 parts, 15 parts, Radix Glycyrrhizae, Engelhardtia roxburghiana 11 parts, 12 parts, Fructus Amomi Rotundus, Chalk 9 parts, Fructus Mume 12 parts, Pericarpium Granati 10 parts, Rhizoma Zingiberis 11 parts, Flos dolichoris 10 parts, 12 parts, Fructus Jujubae, SHIMI 12 parts, Rhizoma Atractylodis 10 parts.

The preparation method of the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation comprises the following steps:

(1) Radix Ginseng, DAWANHUA, Rhizoma Polygonati Cirrhifolii, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Semen Allii Tuberosi, Semen Sesami Nigrum, Elsholtzia regulosa, Radix Glycyrrhizae, Engelhardtia roxburghiana, Fructus Amomi Rotundus, Chalk, Pericarpium Granati, Rhizoma Zingiberis, Flos dolichoris, Rhizoma Atractylodis are ground to 50 orders, add the ethanol of 6 times of above-mentioned Chinese drugs powder, then reflux, extract, 3h is carried out, collect extracting solution and filtering residue, reclaim ethanol, filtering residue is added 5 times of soak by water 2h, collect filtrate, merge twice filtrate;

(2) filtrate obtained for step (1) mixed with the SHIMI of 1/2 quality and stir, mixed liquor being carried out spraying dry, and crosses 80 mesh sieves, obtain mixing Chinese medicinal powder;

(3) SHIMI of residue 1/2 quality is pulverized and Fructus Mume, the little fiery parch of Fructus Jujubae, then grind into powder and cross 80 mesh sieves, obtain mixing Fructus Mume powder;

(4) by the mixing Fructus Mume powder mix homogeneously that mixing Chinese medicinal powder obtained for step (2), step (3) obtain, the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation is obtained.

Embodiment 6

Acute oral toxicity test:

Healthy adult SD rat 40, male and female half and half, body weight is suitable, all between 220 ± 10g, test fasting in first 16 hours, then electuary warm water of the present invention is washed open and rear rat per os administration by gavage repeatedly to be contaminated, given low is 5000mg (effective ingredient)/kg body weight, then fasting 3-4 days is continued, test rat body situation, diet, drinking-water, body weight increase all normal, do not occur obvious intoxicating phenomenon and the phenomena of mortality, place's post mortem Non Apparent Abnormality, judges that this Chinese medicine composition is to the nontoxic level in the true border of rat acute Oral toxicity.

Long term toxicity test:

Healthy adult mice 20, body weight 18-22g, electuary granule of the present invention is mixed and feeds to mice in feedstuff, mice amount is 52.8g crude drug/kg/ days, continuous nursing 10 weeks, drug withdrawal detected the hair of decimal, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat after 3 weeks, the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of test mice all has no significant effect, and internal organs naked eyes do not find difference change.Histological indications shows, medication 10 weeks and drug withdrawal are after 3 weeks, and Organs of Mice all without obviously changing, illustrates that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, does not also have difference reaction, application safety after drug withdrawal.

Embodiment 7

Clinical experimental study:

1, clinical data

Inventor collects 96 routine insufficiency of spleen-qi type diarrhea during menstruation patients altogether, age 20-39 year, 28.5 years old mean age.Clinical manifestation be premenstrual or menstrual period loose stool and diarrhea, distension and fullness in the abdomen, fatigue in both spirit and physical strength, many through row amount, the light matter of color is rare, at ordinary times profuse leukorrhea, and color white matter is glued, and without foul smell, or puffiness of the face and limbs, light red tongue is fat, and tongue is greasy in vain, relaxed and soft pulse.

2, Therapeutic Method

Oral, every day twice, each 10g, washes open by warm water, oral.

Within one month, be a course for the treatment of, suspend a treatment in month after treating three courses for the treatment of, then record result.

3, efficacy evaluation

Cure: normal through row stool, aperiodicity is shown effect.

Take a turn for the better: diarrhea during menstruation number of times reduces, and symptom alleviates.Though or have loose bowels only, recidivist again in 3 menstrual cycle.

Do not heal: diarrhea during menstruation symptom is unchanged.

4, therapeutic outcome

After the treatment of two courses for the treatment of, in 96 routine patients, cure 72 examples, take a turn for the better 22 examples, and do not heal 2 examples; Reach 95.0% through statistical analysis cure rate, total effective rate reaches 97.92%, and over the course for the treatment of, has no any untoward reaction or side effect, shows safe and effective for medication.Without recurrence after drug withdrawal.

5, model case

Case 1: week certain, 29 years old, continuous menstrual period half a year loose stool and diarrhea, many through row amount, the light matter of color is rare, at ordinary times profuse leukorrhea, color white matter is glued, and light red tongue is fat, and tongue is greasy in vain, be diagnosed as insufficiency of spleen-qi type diarrhea during menstruation, after taking 3 courses for the treatment of of Chinese medicine of the present invention, symptom is obviously alleviated, after continuing to take 2 courses for the treatment of of Chinese medicine of the present invention, various symptom disappears substantially, recovers normal, after continue again to take 1 course for the treatment of and consolidate, recovery from illness, follows up a case by regular visits to after half a year without recurrence.

Case 2: Liu, 25 years old, the consecutive numbers moon premenstrual loose stool and diarrhea, distension and fullness in the abdomen, fatigue in both spirit and physical strength, at ordinary times profuse leukorrhea, color white matter is glued, without foul smell, and with puffiness of the face and limbs, light red tongue is fat, tongue is greasy in vain, the symptom of relaxed and soft pulse, is diagnosed as insufficiency of spleen-qi type diarrhea during menstruation, after taking 3 courses for the treatment of of Chinese medicine of the present invention, symptom is obviously alleviated, after continuing to take 1 course for the treatment of of Chinese medicine of the present invention, various symptom disappears substantially, recovers normal, follows up a case by regular visits to without recurrence after 1 year.

The above is the preferred embodiment of the present invention; its object is to allow person skilled in the art understand content of the present invention and to be implemented; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.

Claims (4)

1. treat the electuary of insufficiency of spleen-qi type diarrhea during menstruation for one kind, it is characterized in that, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 15-35 part, DAWANHUA 10-30 part, Rhizoma Polygonati Cirrhifolii 15-25 part, Rhizoma Atractylodis Macrocephalae 20-40 part, Fructus Ligustri Lucidi 10-25 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 10-20 part, Semen Allii Tuberosi 8-16 part, Semen Sesami Nigrum 10-20 part, Elsholtzia regulosa 6-12 part, Radix Glycyrrhizae 10-20 part, Engelhardtia roxburghiana 6-16 part, Fructus Amomi Rotundus 8-16 part, Chalk 6-12 part, Fructus Mume 8-16 part, Pericarpium Granati 6-14 part, Rhizoma Zingiberis 6-16 part, Flos dolichoris 6-14 part, Fructus Jujubae 8-16 part, SHIMI 8-16 part, Rhizoma Atractylodis 6-14 part.

2. a kind of electuary for the treatment of insufficiency of spleen-qi type diarrhea during menstruation as claimed in claim 1, it is characterized in that, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 20-30 part, DAWANHUA 15-25 part, Rhizoma Polygonati Cirrhifolii 18-22 part, Rhizoma Atractylodis Macrocephalae 25-35 part, Fructus Ligustri Lucidi 14-21 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 12-18 part, Semen Allii Tuberosi 10-14 part, Semen Sesami Nigrum 12-18 part, Elsholtzia regulosa 8-10 part, Radix Glycyrrhizae 12-18 part, Engelhardtia roxburghiana 8-14 part, Fructus Amomi Rotundus 10-14 part, Chalk 8-10 part, Fructus Mume 10-14 part, Pericarpium Granati 8-12 part, Rhizoma Zingiberis 8-14 part, Flos dolichoris 8-12 part, Fructus Jujubae 10-14 part, SHIMI 10-14 part, Rhizoma Atractylodis 8-12 part.

3. a kind of electuary for the treatment of insufficiency of spleen-qi type diarrhea during menstruation as claimed in claim 1, it is characterized in that, described Chinese medicine ingredients is made up of the crude drug of following parts by weight: Radix Ginseng 25 parts, DAWANHUA 20 parts, Rhizoma Polygonati Cirrhifolii 20 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Fructus Ligustri Lucidi 18 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 15 parts, Semen Allii Tuberosi 12 parts, Semen Sesami Nigrum 15 parts, Elsholtzia regulosa 9 parts, 15 parts, Radix Glycyrrhizae, Engelhardtia roxburghiana 11 parts, 12 parts, Fructus Amomi Rotundus, Chalk 9 parts, Fructus Mume 12 parts, Pericarpium Granati 10 parts, Rhizoma Zingiberis 11 parts, Flos dolichoris 10 parts, 12 parts, Fructus Jujubae, SHIMI 12 parts, Rhizoma Atractylodis 10 parts.

4. a kind of preparation method for the treatment of the electuary of insufficiency of spleen-qi type diarrhea during menstruation as described in claim 1-3 any one, is characterized in that, comprise the following steps:

(1) Radix Ginseng, DAWANHUA, Rhizoma Polygonati Cirrhifolii, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Semen Allii Tuberosi, Semen Sesami Nigrum, Elsholtzia regulosa, Radix Glycyrrhizae, Engelhardtia roxburghiana, Fructus Amomi Rotundus, Chalk, Pericarpium Granati, Rhizoma Zingiberis, Flos dolichoris, Rhizoma Atractylodis are ground to 50 orders, add the 4-6 ethanol doubly of above-mentioned Chinese drugs powder, then reflux, extract, 2-3h is carried out, collect extracting solution and filtering residue, reclaim ethanol, filtering residue is added 3-5 times of soak by water 1-2h, collect filtrate, merge twice filtrate;

(2) filtrate obtained for step (1) mixed with the SHIMI of 1/2 quality and stir, mixed liquor being carried out spraying dry, and crosses 80 mesh sieves, obtain mixing Chinese medicinal powder;

(3) SHIMI of residue 1/2 quality is pulverized and Fructus Mume, the little fiery parch of Fructus Jujubae, then grind into powder and cross 80 mesh sieves, obtain mixing Fructus Mume powder;

(4) by the mixing Fructus Mume powder mix homogeneously that mixing Chinese medicinal powder obtained for step (2), step (3) obtain, the electuary of described treatment insufficiency of spleen-qi type diarrhea during menstruation is obtained.