CN104001163B - A kind of pharmaceutical composition treating infantile enteritis and preparation method thereof - Google Patents
A kind of pharmaceutical composition treating infantile enteritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical composition treating infantile enteritis and preparation method thereof, the pharmaceutical composition of this treatment infantile enteritis has following major ingredient and adjuvant to make, major ingredient: Herba Asari, Herba Artemisiae Annuae, Rhizoma Coptidis, Herba Euphorbiae Humifusae, Radix Sophorae Flavescentis, eucalyptus leaves, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Plantula Papaveris, Herba Pogostemonis, Poria, Pericarpium Arecae, Folium Perillae, the Radix Angelicae Dahuricae, Pericarpium Citri tangerinae, Cortex Magnoliae Officinalis, Radix Glycyrrhizae, Ramulus Cinnamomi, roud cardamon seed, Hedyotis chrysotricha, the Radix Pulsatillae, Caulis Lonicerae；Adjuvant: Margarita powder, jelly powder, tannalbin, pepsin, polyzyme tablets, lactasinum, yeast tablet, lactic acid calcium powder, compound vitamin.This choice of drug is all the medical material that the property of medicine is gentle; from protection gastrointestinal mucosa, antidiarrheal, aid digestion, town is told, supplement essential nutrients, clearing away heat-damp and promoting diuresis many aspects play effect, for infantile enteritis determined curative effect, taking convenience; safe without toxic side effect, is suitable for batch production.
Description
Technical field
The present invention relates to department of pediatrics field of medicaments, particularly relate to a kind of pharmaceutical composition treating infantile enteritis and
Preparation method.
Background technology
Infantile enteritis major part causes due to bacterial infection or virus, it is possible to because of affection of exogenous wind-cold or damp and hot
Causing, slightly show as times of defecation and increase, moderate shows as defecating more than 10 times, in egg drop soup sample every day
Or water sample, there is a dehydrating phenomena, dyspepsia, flatulence, hyperenteritis shows as defecating spouting, severe
Dehydration, xerosis cutis, breathe discomfort, collapse, nutrient deficiency, even go into a coma.
After children's suffers from enteritis, passive protective physical fitness is poor, weakness of the spleen and stomach, and the food eaten into easily is vomitted out,
So the medicine that should not take the property of medicine in a large number stronger is treated, children's is stimulated too big by existing clysmata,
And antibiotic can produce drug resistance, it is not good Therapeutic Method, so it is gentle to be badly in need of a kind of property of medicine, energy
Enough protect intestinal mucosa, spleen invigorating can adjust stomach, extra-nutrition material again, strengthen the medicine of infant resistance.
Summary of the invention
Present invention solves the technical problem that and be: provide a kind of property of medicine gentle, it is possible to protection intestinal mucosa, can be good for again
Spleen adjusts stomach, extra-nutrition material, strengthens the medicine of infant resistance.Determined curative effect, taking convenience, safety
Have no side effect.
It is yet another object of the invention to provide the preparation method of a kind of pharmaceutical composition treating infantile enteritis.
The technical scheme is that
A kind of pharmaceutical composition treating infantile enteritis, including major ingredient and adjuvant, described major ingredient component and weight
Part is: Herba Asari 5-10 part, Herba Artemisiae Annuae 15-30 part, Rhizoma Coptidis 3-6 part, Herba Euphorbiae Humifusae 5-20 part, Radix Sophorae Flavescentis 6-
20 parts, eucalyptus leaves 18-24 part, Radix Saposhnikoviae 4-10 part, Rhizoma Atractylodis Macrocephalae 10-16 part, Plantula Papaveris 0.8-2 part, Herba Pogostemonis
8-16 part, Poria 5-8 part, Pericarpium Arecae 6-18 part, Folium Perillae 5-15 part, Radix Angelicae Dahuricae 6-9 part, Pericarpium Citri tangerinae 3-
8 parts, Cortex Magnoliae Officinalis 4-6 part, Radix Glycyrrhizae 6-14 part, Ramulus Cinnamomi 15-25 part, roud cardamon seed 7-15 part, Hedyotis chrysotricha
4-8 part, Radix Pulsatillae 6-14 part, Caulis Lonicerae 3-9 part；Described adjuvant component and weight portion be: Margarita powder
0.3-0.6 part, jelly powder 0.5-0.6 part, tannalbin 0.2-0.4 part, pepsin 0.01-0.02
Part, polyzyme tablets 0.15-0.25 part, yeast tablet 0.02-0.04 part, lactic acid calcium powder 0.1-0.2 part, compound
Vitamin 3-5 part.
Specifically, the pharmaceutical composition of described treatment infantile enteritis, including major ingredient and adjuvant, described major ingredient group
Point and weight portion be: Herba Asari 7.5 parts, Herba Artemisiae Annuae 22.5 parts, Rhizoma Coptidis 4.5 parts, Herba Euphorbiae Humifusae 12.5 parts,
Radix Sophorae Flavescentis 13 parts, eucalyptus leaves 21 parts, Radix Saposhnikoviae 7 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Plantula Papaveris 1.4 parts, Herba Pogostemonis 12 parts,
6.5 parts of Poria, Pericarpium Arecae 12 parts, Folium Perillae 10 parts, the Radix Angelicae Dahuricae 7.5 parts, Pericarpium Citri tangerinae 5.5 parts, Cortex Magnoliae Officinalis 5
Part, 10 parts of Radix Glycyrrhizae, Ramulus Cinnamomi 20 parts, roud cardamon seed 11 parts, Hedyotis chrysotricha 6 parts, the Radix Pulsatillae 10 parts, silver
6 parts of rattan of flower；Described adjuvant component and weight portion be: Margarita powder 0.45 part, jelly powder 0.55 part, tannic acid
0.3 part of albumen, pepsin 0.015 part, polyzyme tablets 0.20 part, yeast tablet 0.03 part, lactic acid calcium powder
0.15 part, compound vitamin 4 parts.
Further, described compound vitamin is vitamin A, vitamin B2, ascorbic mixing
Thing.
The present invention also provides for the preparation method of a kind of pharmaceutical composition treating infantile enteritis, including following step
Rapid:
(1) by formula ratio weigh Herba Asari, Herba Artemisiae Annuae, Herba Euphorbiae Humifusae, eucalyptus leaves, Folium Perillae, Pericarpium Arecae,
Cortex Magnoliae Officinalis, the Radix Pulsatillae, use ethanol extract from water precipitation, first use alcohol steep medicinal ingredient, obtain lixiviating solution, add
Heat, solvent being condensed again after distillating and flows back to extract in infuser medical material, so going round and beginning again, until effectively becoming
Divide and extract completely, filter, reclaim ethanol, separate to obtain extracting solution, then by pure water precipitation, remove impurity,
Concentrate under reduced pressure at low temperature obtains the extractum that water content is 5-18%, standby；
(2) by formula ratio weigh Rhizoma Coptidis, Radix Sophorae Flavescentis, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Plantula Papaveris, Herba Pogostemonis, Poria, the Radix Angelicae Dahuricae,
Pericarpium Citri tangerinae, Radix Glycyrrhizae, Ramulus Cinnamomi, roud cardamon seed, Hedyotis chrysotricha, Caulis Lonicerae, pulverize, add water to exceed medical material surface
3-5 centimetre, pressurized high-temperature extracts, intense fire heated and boiled, changes low baking temperature and keeps slight boiling condition, in order to avoid medicine juice overflows
Going out or too fast boil dry, slow down water evaporates, beneficially the dissolution of active ingredient, extracts 2-3 time, carries every time
The time of taking is 30-50 minute, and the Chinese medicine extracted to leach while hot, in order to avoid active ingredient is deposited in medicinal residues
On, united extraction liquid, it is concentrated into the concentrated solution that water content is 40-50%, regulates PH to 5.0-7.0, use second
Alcohol processes, and precipitated impurities is concentrated to give the extractum that water content is 5-20% again, standby；
(3) weigh adjuvant by formula ratio, make solvent with pure water, after dissolving, with step (2),
(3) the extractum mixing prepared, obtains the pharmaceutical preparation of the treatment infantile enteritis of the present invention.
Further, the preparation of the pharmaceutical composition of described treatment infantile enteritis is syrup, oral liquid.
Further, the preparation method of the syrup of the pharmaceutical composition of described treatment infantile enteritis is:
(1) by formula ratio weigh Herba Asari, Herba Artemisiae Annuae, Herba Euphorbiae Humifusae, eucalyptus leaves, Folium Perillae, Pericarpium Arecae,
Cortex Magnoliae Officinalis, the Radix Pulsatillae, use ethanol extract from water precipitation, first use alcohol steep medicinal ingredient, obtain lixiviating solution, add
Heat, solvent being condensed again after distillating and flows back to extract in infuser medical material, so going round and beginning again, until effectively becoming
Divide and extract completely, filter, reclaim ethanol, separate to obtain extracting solution, then by pure water precipitation, remove impurity,
Concentrate under reduced pressure at low temperature obtains the extractum that water content is 10-18%, standby；
(2) Rhizoma Coptidis, Radix Sophorae Flavescentis, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Plantula Papaveris, Herba Pogostemonis, Poria, white is weighed by formula ratio
The root of Dahurian angelica, Pericarpium Citri tangerinae, Radix Glycyrrhizae, Ramulus Cinnamomi, roud cardamon seed, Hedyotis chrysotricha, Caulis Lonicerae, pulverize, add water to exceed medical material
3-5 centimetre of surface, pressurized high-temperature extracts, intense fire heated and boiled, changes low baking temperature and keeps slight boiling condition, in order to avoid medicine
Juice overflows or too fast boils dry, and slow down water evaporates, beneficially the dissolution of active ingredient, extracts 2-3 time, often
Secondary extraction time is 30-50 minute, and the Chinese medicine extracted to leach while hot, in order to avoid active ingredient is deposited in medicine
On slag, united extraction liquid, it is concentrated into the concentrated solution that water content is 40-50%, regulates PH to 5.0-7.0, use
Ethanol Treatment, precipitated impurities, again it is concentrated to give the extractum that water content is 10-20%, standby；
(3) weighing adjuvant by formula ratio, after dissolving, the extractum prepared with step (2), (3) mixes
Close, addition stevioside: sucrose 30-50 part, steviosin 2-4 part, addition aromatic: Oleum menthae 0.2-
0.4 part, Oleum Cinnamomi 0.15-0.25 part, addition mucilage: starch 50-80 part, arabic gum 2-5
Part, pectin 3-8 part, agar 3-6 part, mixing, subpackage, obtain the sugar of the treatment infantile enteritis of the present invention
Slurry.
Further, the preparation method of the oral liquid of the pharmaceutical composition of described treatment infantile enteritis is:
(1) by formula ratio weigh Herba Asari, Herba Artemisiae Annuae, Herba Euphorbiae Humifusae, eucalyptus leaves, Folium Perillae, Pericarpium Arecae,
Cortex Magnoliae Officinalis, the Radix Pulsatillae, use ethanol extract from water precipitation, first use alcohol steep medicinal ingredient, obtain lixiviating solution, add
Heat, solvent being condensed again after distillating and flows back to extract in infuser medical material, so going round and beginning again, until effectively becoming
Divide and extract completely, filter, reclaim ethanol, separate to obtain extracting solution, then by pure water precipitation, remove impurity,
Concentrate under reduced pressure at low temperature obtains the extractum that water content is 5-10%, standby；
(2) Rhizoma Coptidis, Radix Sophorae Flavescentis, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Plantula Papaveris, Herba Pogostemonis, Poria, white is weighed by formula ratio
The root of Dahurian angelica, Pericarpium Citri tangerinae, Radix Glycyrrhizae, Ramulus Cinnamomi, roud cardamon seed, Hedyotis chrysotricha, Caulis Lonicerae, pulverize, add water to exceed medical material
3-5 centimetre of surface, pressurized high-temperature extracts, intense fire heated and boiled, changes low baking temperature and keeps slight boiling condition, in order to avoid medicine
Juice overflows or too fast boils dry, and slow down water evaporates, beneficially the dissolution of active ingredient, extracts 2-3 time, often
Secondary extraction time is 30-50 minute, and the Chinese medicine extracted to leach while hot, in order to avoid active ingredient is deposited in medicine
On slag, united extraction liquid, it is concentrated into the concentrated solution that water content is 40-50%, regulates PH to 5.0-7.0, use
Ethanol Treatment, precipitated impurities, again it is concentrated to give the extractum that water content is 5-10%, standby；
(3) weighing adjuvant by formula ratio, after dissolving, the extractum prepared with step (2), (3) mixes
Close, addition stevioside: sucrose 30-50 part, steviosin 2-4 part, addition aromatic: Oleum menthae 0.2-
0.4 part, Oleum Cinnamomi 0.15-0.25 part, the ethanol of addition 20%, as preservative, puts into refrigerator-freezer after preparing medicine
Cold preservation, filters again, canned, obtains the oral liquid of the treatment infantile enteritis of the present invention.
Usage and consumption:
Syrup: 3-12 month children's, each 4-6ml, twice daily；12-24 month children's, each 6-
12 exert oneself ml, three times a day；The 2-4 year each 12-20ml of children's, three times a day；Within more than 4 years old, children's is each
25ml, three times a day.Boiled water is drunk after dissolving into diluter juice.
Oral liquid: 3-12 month children's, each 5-8ml, twice daily；12-24 month children's, every time
8-15 exerts oneself ml, three times a day；The 2-4 year each 15-25ml of children's, three times a day；Within more than 4 years old, children's is every
Secondary 30ml, three times a day.
Compared with prior art, the technique effect of the present invention is embodied in:
First, in selected medical material, Herba Asari, slightly sweet flavor, micro-toil, gas is fragrant, and property is put down, nontoxic, enters
Small intestinal, bladder warp, XIAOFENG SAN gas expelling summer-heat for oral administration, inducing diuresis for treating stranguria syndrome goes to amass；Herba Artemisiae Annuae, diuresis, removing heat from blood, only
Large intestine wind heat hematochezia, controls food stagnation of child；Rhizoma Coptidis, bitter in the mouth, it is slightly cold, nontoxic, except water conservancy bone, adjust stomach, thick
Intestinal；Herba Euphorbiae Humifusae, hemostasis, diuresis, stomach invigorating, promoting blood circulation and detoxication, diarrhoea；Radix Sophorae Flavescentis, bitter in the mouth, cold in nature, return
Warp, liver, kidney, large intestine, small intestine meridian, bladder, heart channel, main damp-heat dysentery, discharging fresh blood stool, control in abdomen cold
Bitterly, attacked by pestiferous factors is suffered from abdominal pain, and except body is vexed, controls trusted subordinate's accumulation；Eucalyptus leaves, micro-hardship pungent, micro-, flat, control intestinal mycete
Disease, gastroenteritis；Radix Saposhnikoviae, acrid in the mouth, sweet, slightly warm in nature, return bladder warp, lung meridian, spleen channel, Liver Channel, control big
Loose stool is let out, and spleen eliminating pathogen in the liver victory of relaxing is wet；Tannalbin: do not decompose at gastric after taking, decomposites tan at small intestinal
Acid, makes intestinal mucosa S-layer proteins solidify, and forms layer protecting film, and minimizing is oozed out, and alleviates stimulation and intestinal is compacted
Dynamic, there are convergence, anti-diarrhea effect；Margarita powder can enhancing immunity, supplement calcium, improvement sleep, treatment
Ulcer, protection intestinal mucosa；
In selected medical material, the Rhizoma Atractylodis Macrocephalae is bitter, sweet, temperature, returns spleen, stomach warp, spleen reinforcing, stomach reinforcing, dampness, and
In, control deficient QI of the spleen and stomach, anorexia, the few gas of asthenia, deficiency-distension, have loose bowels；Plantula Papaveris, sour, puckery, flat, return
With the passing of time large intestine, lung, kidney channel, control dysentery, and intestinal slips anus, has blood in stool, relieving diarrhea with astringents；Herba Pogostemonis, pungent, micro-
Temperature, returns spleen, stomach, lung meridian, and gastral cavity painful abdominal mass is vomitted, and taste dampness, distension and fullness in the abdomen, limbs are the most tired, nausea and vomiting
Effectively；The Radix Pulsatillae, returns stomach warp, large intestine channel, removes intestinal dirt, and removing food stagnancy is stagnant；Pericarpium Arecae acrid in the mouth, slightly warm in nature, return
Spleen, stomach, large intestine, small intestine meridian, logical intestine and small intestine, spleen benefiting and stimulating the appetite, in tune, eliminating the pathogens from the lung, easing stomach-QI, wide intestinal disappears
Swollen；Folium Perillae, pungent, tepor, nontoxic, control enteritis, disorder of stomach-QI, gastral cavity abdominal distention is vexed；Radix Angelicae Dahuricae acrid in the mouth, property
Temperature, returns lung, stomach, large intestine channel, fragrance to rise and dissipates, control wet Sheng chronic diarrhea, hemorrhoidal hamorrhage anal fistula；Pericarpium Citri tangerinae, pungent, bitter,
Temperature, enters lung, liver, spleen, stomach four warp, for the diseases such as distension and fullness of the chest and abdomen, spleen benefiting and stimulating the appetite, it is adaptable to taste are empty
The diseases such as weak, diet minimizing, dyspepsia, loose stool and diarrhea, Radix Platycodonis suppression gastric secretion and antiulcer；Thick
Piao, acrid in the mouth, warm in nature, spleen channel, stomach warp, large intestine channel, circulation of qi promoting removing food stagnancy；Jelly powder can stomach invigorating, aid digestion,
Increase appetite, be the health food of child；Pepsin helps digestive function.；Containing pancreas fat in polyzyme tablets
Enzyme, pancreatic amylase, trypsin, pancreatic lipase can make steatolysis be glycerol and fatty acid, pancreatic amylase
Can make Starch Conversion is sugar, and trypsin can make protein be converted into peptone: pepsin can make protein turn
Turn to albumen and peptone, Papillary, can facilitating digestion, appetite stimulator；
In selected medical material, Radix Glycyrrhizae, sweet, flat, to process sweet, temperature, glycyrrhiza preparation can promote that stomach mucus is formed
And secretion, extend the epithelial cell life-span, have anti-inflammatory activity；Ramulus Cinnamomi, its nature and flavor acrid, sweet, warm, enter lung,
The heart, bladder warp, be to cure mainly the drugs for dispelling internal cold that interior cold is conventional, have complement sun, promoting blood circulation, the merit of warming the spleen and stomach
Effect；Roud cardamon seed regulating the flow of QI to ease the stomach, dry cold-damp, the disease such as abdominal distention for the treatment of for stomachache, eructation regurgitation, vomiting；
In selected medical material, Poria, sweet, light, flat, GUIXIN, spleen, kidney channel, Poria containing pachyman,
Glucose, protein, aminoacid, organic acid, fat, lecithin, adenine, choline, Ergota steroid
Alcohol, multiple enzyme and potassium salt, nutritious；Yeast tablet is mainly used in vitimin supplement B, treats to digestion not
Good or inappetence etc.；Lactic acid calcium powder is dissolved in water and becomes ionic condition, also referred to as ionized calcium type, its pH value in
Neutrality, does not hinder the intestines and stomach, for children's's supplement calcium；Compound vitamin can provide the dimension life of abundance for children's
Element, enhancing immunity, accelerate the state of an illness and recover；
In selected medical material, Hedyotis chrysotricha, clearing away heat-damp and promoting diuresis, control vomiting and diarrhoea, dysentery, have blood in stool；Caulis Lonicerae is sweet,
Cold, attach to the lung and stomach meridians, generate heat for epidemic febrile disease, toxic-heat and blood stasis.
Second, according to children's's feature, medicine makes syrup or oral liquid, adds one when of making medicament
Fixed sweeting agent and correctives, make medicine be easier to by child administration, overcome common Chinese bitter in the mouth, medicine feed
The shortcoming of difficulty.
3rd, compare clysmata or antibiotherapy, the medicine property of medicine of the present invention is gentle, it is possible to protection the intestines and stomach glues
Film, antidiarrheal, aid digestion, town is told, supplement essential nutrients, clearing away heat-damp and promoting diuresis, preferably lower for the resistance
Children taking, and determined curative effect, infant recovers fast, safe without toxic side effect.
Detailed description of the invention
Below in conjunction with specific embodiment and test example, the present invention is further detailed explanation:
Embodiment
Embodiment 1:
The syrup of a kind of pharmaceutical composition treating infantile enteritis, including raw material and adjuvant, major ingredient component and weight
Amount part is: Herba Asari 5 parts, Herba Artemisiae Annuae 15 parts, Rhizoma Coptidis 3 parts, Herba Euphorbiae Humifusae 5 parts, Radix Sophorae Flavescentis 6 parts, eucalyptus leaves
18 parts, Radix Saposhnikoviae 4 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Plantula Papaveris 0.8 part, Herba Pogostemonis 8 parts, 5 parts of Poria, Pericarpium Arecae 6
Part, Folium Perillae 5 parts, the Radix Angelicae Dahuricae 6 parts, Pericarpium Citri tangerinae 3 parts, Cortex Magnoliae Officinalis 4 parts, 6 parts of Radix Glycyrrhizae, Ramulus Cinnamomi 15 parts, white
KOUREN 7 parts, Hedyotis chrysotricha 4 parts, the Radix Pulsatillae 6 parts, Caulis Lonicerae 3 parts；Adjuvant component and weight portion be:
Margarita powder 0.3 part, jelly powder 0.5 part, tannalbin 0.2 part, pepsin 0.01 part, polyzyme tablets
0.15 part, yeast tablet 0.02 part, lactic acid calcium powder 0.1 part, compound vitamin 3 parts.
Preparation technology is:
(1) by formula ratio weigh Herba Asari, Herba Artemisiae Annuae, Herba Euphorbiae Humifusae, eucalyptus leaves, Folium Perillae, Pericarpium Arecae,
Cortex Magnoliae Officinalis, the Radix Pulsatillae, use ethanol extract from water precipitation, first use alcohol steep medicinal ingredient, obtain lixiviating solution, add
Heat, solvent being condensed again after distillating and flows back to extract in infuser medical material, so going round and beginning again, until effectively becoming
Divide and extract completely, filter, reclaim ethanol, separate to obtain extracting solution, then by pure water precipitation, remove impurity,
Concentrate under reduced pressure at low temperature obtains the extractum that water content is 10%, standby；
(2) Rhizoma Coptidis, Radix Sophorae Flavescentis, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Plantula Papaveris, Herba Pogostemonis, Poria, white is weighed by formula ratio
The root of Dahurian angelica, Pericarpium Citri tangerinae, Radix Glycyrrhizae, Ramulus Cinnamomi, roud cardamon seed, Hedyotis chrysotricha, Caulis Lonicerae, pulverize, add water to exceed medical material
3 centimetres of surface, pressurized high-temperature extracts, intense fire heated and boiled, changes low baking temperature and keeps slight boiling condition, in order to avoid medicine juice
Overflowing or too fast boil dry, slow down water evaporates, beneficially the dissolution of active ingredient, extracts 2 times, carries every time
The time of taking is 30 minutes, and the Chinese medicine extracted to leach while hot, in order to avoid active ingredient is deposited on medicinal residues, closes
And extracting solution, it is concentrated into the concentrated solution that water content is 40%, regulates PH to 5.0, by Ethanol Treatment, precipitate miscellaneous
Matter, is concentrated to give the extractum that water content is 10% again, standby；
(3) weighing adjuvant by formula ratio, after dissolving, the extractum prepared with step (2), (3) mixes
Close, addition stevioside: sucrose 30 parts, steviosin 2 parts, addition aromatic: Oleum menthae 0.2 part, osmanthus
Haze wax 0.15 part, addition mucilage: starch 50 parts, arabic gum 2 parts, pectin 3 parts, agar 3
Part, mixing, subpackage, obtain the syrup of the treatment infantile enteritis of the present invention.
Usage and consumption: 3-12 month children's, each 4-6ml, twice daily；12-24 month children's,
6-12 exerts oneself ml, three times a day every time；The 2-4 year each 12-20ml of children's, three times a day；More than 4 years old little
The each 25ml of youngster, three times a day.Boiled water is drunk after dissolving into diluter juice.
Embodiment 2:
A kind of oral liquid of the pharmaceutical composition treating infantile enteritis, including raw material and adjuvant, major ingredient component and
Weight portion is: Herba Asari 7.5 parts, Herba Artemisiae Annuae 22.5 parts, Rhizoma Coptidis 4.5 parts, Herba Euphorbiae Humifusae 12.5 parts, Radix Sophorae Flavescentis
13 parts, eucalyptus leaves 21 parts, Radix Saposhnikoviae 7 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Plantula Papaveris 1.4 parts, Herba Pogostemonis 12 parts, Poria
6.5 parts, Pericarpium Arecae 12 parts, Folium Perillae 10 parts, the Radix Angelicae Dahuricae 7.5 parts, Pericarpium Citri tangerinae 5.5 parts, Cortex Magnoliae Officinalis 5 parts,
10 parts of Radix Glycyrrhizae, Ramulus Cinnamomi 20 parts, roud cardamon seed 11 parts, Hedyotis chrysotricha 6 parts, the Radix Pulsatillae 10 parts, Caulis Lonicerae
6 parts；Adjuvant component and weight portion be: Margarita powder 0.45 part, jelly powder 0.55 part, tannalbin 0.3
Part, pepsin 0.015 part, polyzyme tablets 0.20 part, yeast tablet 0.03 part, lactic acid calcium powder 0.15 part,
Compound vitamin 4 parts.
Preparation technology is:
(1) by formula ratio weigh Herba Asari, Herba Artemisiae Annuae, Herba Euphorbiae Humifusae, eucalyptus leaves, Folium Perillae, Pericarpium Arecae,
Cortex Magnoliae Officinalis, the Radix Pulsatillae, use ethanol extract from water precipitation, first use alcohol steep medicinal ingredient, obtain lixiviating solution, add
Heat, solvent being condensed again after distillating and flows back to extract in infuser medical material, so going round and beginning again, until effectively becoming
Divide and extract completely, filter, reclaim ethanol, separate to obtain extracting solution, then by pure water precipitation, remove impurity,
Concentrate under reduced pressure at low temperature obtains the extractum that water content is 5%, standby；
(2) Rhizoma Coptidis, Radix Sophorae Flavescentis, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Plantula Papaveris, Herba Pogostemonis, Poria, white is weighed by formula ratio
The root of Dahurian angelica, Pericarpium Citri tangerinae, Radix Glycyrrhizae, Ramulus Cinnamomi, roud cardamon seed, Hedyotis chrysotricha, Caulis Lonicerae, pulverize, add water to exceed medical material
4 centimetres of surface, pressurized high-temperature extracts, intense fire heated and boiled, changes low baking temperature and keeps slight boiling condition, in order to avoid medicine juice
Overflowing or too fast boil dry, slow down water evaporates, beneficially the dissolution of active ingredient, extracts 2 times, carries every time
The time of taking is 40 minutes, and the Chinese medicine extracted to leach while hot, in order to avoid active ingredient is deposited on medicinal residues, closes
And extracting solution, it is concentrated into the concentrated solution that water content is 45%, regulates PH to 6.0, by Ethanol Treatment, precipitate miscellaneous
Matter, is concentrated to give the extractum that water content is 5% again, standby；
(3) weighing adjuvant by formula ratio, after dissolving, the extractum prepared with step (2), (3) mixes
Close, addition stevioside: sucrose 40 parts, steviosin 3 parts, addition aromatic: Oleum menthae 0.3 part, osmanthus
Haze wax 0.2 part, the ethanol of addition 20%, as preservative, puts into refrigerator for cold after preparing medicine, again mistake
Filter, canned, obtain the oral liquid of the treatment infantile enteritis of the present invention.
Usage and consumption: 3-12 month children's, each 5-8ml, twice daily；12-24 month children's,
8-15 exerts oneself ml, three times a day every time；The 2-4 year each 15-25ml of children's, three times a day；More than 4 years old little
The each 30ml of youngster, three times a day.
Embodiment 3:
A kind of oral liquid of the pharmaceutical composition treating infantile enteritis, including raw material and adjuvant, major ingredient component and
Weight portion is: Herba Asari 10 parts, Herba Artemisiae Annuae 30 parts, Rhizoma Coptidis 6 parts, Herba Euphorbiae Humifusae 20 parts, Radix Sophorae Flavescentis 20 parts,
Eucalyptus leaves 24 parts, Radix Saposhnikoviae 10 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Plantula Papaveris 2 parts, Herba Pogostemonis 16 parts, 8 parts of Poria, big
Pericarpium Arecae 18 parts, Folium Perillae 15 parts, the Radix Angelicae Dahuricae 9 parts, Pericarpium Citri tangerinae 8 parts, Cortex Magnoliae Officinalis 6 parts, 14 parts of Radix Glycyrrhizae, Ramulus Cinnamomi
25 parts, roud cardamon seed 15 parts, Hedyotis chrysotricha 8 parts, the Radix Pulsatillae 14 parts, Caulis Lonicerae 9 parts；Adjuvant component and
Weight portion is: Margarita powder 0.6 part, jelly powder 0.6 part, tannalbin 0.4 part, pepsin 0.02
Part, polyzyme tablets 0.25 part, yeast tablet 0.04 part, lactic acid calcium powder 0.2 part, compound vitamin 5 parts.
Preparation technology is:
(1) by formula ratio weigh Herba Asari, Herba Artemisiae Annuae, Herba Euphorbiae Humifusae, eucalyptus leaves, Folium Perillae, Pericarpium Arecae,
Cortex Magnoliae Officinalis, the Radix Pulsatillae, use ethanol extract from water precipitation, first use alcohol steep medicinal ingredient, obtain lixiviating solution, add
Heat, solvent being condensed again after distillating and flows back to extract in infuser medical material, so going round and beginning again, until effectively becoming
Divide and extract completely, filter, reclaim ethanol, separate to obtain extracting solution, then by pure water precipitation, remove impurity,
Concentrate under reduced pressure at low temperature obtains the extractum that water content is 10%, standby；
(2) Rhizoma Coptidis, Radix Sophorae Flavescentis, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Plantula Papaveris, Herba Pogostemonis, Poria, white is weighed by formula ratio
The root of Dahurian angelica, Pericarpium Citri tangerinae, Radix Glycyrrhizae, Ramulus Cinnamomi, roud cardamon seed, Hedyotis chrysotricha, Caulis Lonicerae, pulverize, add water to exceed medical material
5 centimetres of surface, pressurized high-temperature extracts, intense fire heated and boiled, changes low baking temperature and keeps slight boiling condition, in order to avoid medicine juice
Overflowing or too fast boil dry, slow down water evaporates, beneficially the dissolution of active ingredient, extracts 3 times, carries every time
The time of taking is 50 minutes, and the Chinese medicine extracted to leach while hot, in order to avoid active ingredient is deposited on medicinal residues, closes
And extracting solution, it is concentrated into the concentrated solution that water content is 50%, regulates PH to 7.0, by Ethanol Treatment, precipitate miscellaneous
Matter, is concentrated to give the extractum that water content is 10% again, standby；
(3) weighing adjuvant by formula ratio, after dissolving, the extractum prepared with step (2), (3) mixes
Close, addition stevioside: sucrose 50 parts, steviosin 4 parts, addition aromatic: Oleum menthae 0.4 part, osmanthus
Haze wax 0.25 part, the ethanol of addition 20%, as preservative, puts into refrigerator for cold after preparing medicine, again mistake
Filter, canned, obtain the oral liquid of the treatment infantile enteritis of the present invention.
Usage and consumption: 3-12 month children's, each 5-8ml, twice daily；12-24 month children's,
8-15 exerts oneself ml, three times a day every time；The 2-4 year each 15-25ml of children's, three times a day；More than 4 years old little
The each 30ml of youngster, three times a day.
Clinical trial example
According to clinical verification, applying Drug therapy infantile enteritis 60 example of the present invention, wherein cure rate is 86%, always
Effective percentage is 94%.
Infant 1: grandson, man, 8 months, slight enteritis, within one day, defecate 6-8 time, the dilutest, invisible
Shape, slightly generates heat, and takes the present invention and treats the medicine of infantile enteritis after 1 day, and temperature recovery is normal, takes
After 2 days, every day defecation 2-3 time, defecate molding.
Infant 2: solve certain, female 1.5 years old, moderate enteritis, within one day, defecate 12-15 time, big for egg flower shape
Just, with mucus and blood, abdominal distention, indigestion after feed, anorexia, take the present invention and treat infantile enteritis
After medicine 1 day, temperature decline, after taking 2 days, defecation frequency significantly reduces, gradually molding of defecating, clothes
After 3 days, can normally take food, every day, defecation 2-3 time, was almost recovered.
Infant 3: soup, man, 4 years old, suffer from hyperenteritis, water sample stool is spouting, and severe takes off
Water, urine minimizing, enophthalmos,enophthalmus, semicoma state, waist expander, vomiting, breathe discomfort, take
The present invention treated the medicine of infantile enteritis after 2 days, and defecation frequency reduces, and after taking 3 days, waist and belly expands
Disappearing, no longer vomit, appetite increases, after taking 4 days, and molding of defecating, it is almost recovered.
Claims (4)
1. the pharmaceutical composition treating infantile enteritis, it is characterised in that include major ingredient and adjuvant, described major ingredient component and weight
Part is: Herba Asari 5-10 part, Herba Artemisiae Annuae 15-30 part, Rhizoma Coptidis 3-6 part, Herba Euphorbiae Humifusae 5-20 part, Radix Sophorae Flavescentis 6-20 part, eucalyptus leaves
18-24 part, Radix Saposhnikoviae 4-10 part, Rhizoma Atractylodis Macrocephalae 10-16 part, Plantula Papaveris 0.8-2 part, Herba Pogostemonis 8-16 part, Poria 5-8 part, big abdomen
Skin 6-18 part, Folium Perillae 5-15 part, Radix Angelicae Dahuricae 6-9 part, Pericarpium Citri tangerinae 3-8 part, Cortex Magnoliae Officinalis 4-6 part, Radix Glycyrrhizae 6-14 part, Ramulus Cinnamomi
15-25 part, roud cardamon seed 7-15 part, Hedyotis chrysotricha 4-8 part, Radix Pulsatillae 6-14 part, Caulis Lonicerae 3-9 part；Described adjuvant group
Divide and weight portion is: Margarita powder 0.3-0.6 part, jelly powder 0.5-0.6 part, tannalbin 0.2-0.4 part, pepsin
0.01-0.02 part, polyzyme tablets 0.15-0.25 part, yeast tablet 0.02-0.04 part, lactic acid calcium powder 0.1-0.2 part, compound dimension
Raw element 3-5 part；
Described compound vitamin is vitamin A, vitamin B2, ascorbic mixture；
The pharmaceutical composition of described treatment infantile enteritis is prepared by following methods, comprises the following steps:
(1) weigh Herba Asari, Herba Artemisiae Annuae, Herba Euphorbiae Humifusae, eucalyptus leaves, Folium Perillae, Pericarpium Arecae, Cortex Magnoliae Officinalis, the Radix Pulsatillae by formula ratio, adopt
With ethanol extract from water precipitation, alcohol reflux, filter, reclaim ethanol, separate to obtain extracting solution, then precipitate with pure water, remove miscellaneous
Matter, concentrate under reduced pressure at low temperature obtains the extractum that water content is 5-18%, standby；
(2) Rhizoma Coptidis, Radix Sophorae Flavescentis, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Plantula Papaveris, Herba Pogostemonis, Poria, the Radix Angelicae Dahuricae, Pericarpium Citri tangerinae, Radix Glycyrrhizae, osmanthus are weighed by formula ratio
Branch, roud cardamon seed, Hedyotis chrysotricha, Caulis Lonicerae, pulverize, and adds water to exceed 3-5 centimetre of medical material surface, and pressurized high-temperature extracts, military
Fire heated and boiled, changes low baking temperature and keeps slight boiling condition, extract 2-3 time, and each extraction time is 30-50 minute, filters, and merges
Extracting solution, is concentrated into the concentrated solution that water content is 40-50%, regulates PH to 5.0-7.0, by Ethanol Treatment, and precipitated impurities,
Again it is concentrated to give the extractum that water content is 5-20%, standby；
(3) weighing adjuvant by formula ratio, make solvent with pure water, after dissolving, the extractum prepared with step (2), (3) mixes, i.e.
Obtain the pharmaceutical composition of described treatment infantile enteritis.
2. the pharmaceutical composition treating infantile enteritis, it is characterised in that include major ingredient and adjuvant, described major ingredient component and weight
Part is: Herba Asari 7.5 parts, Herba Artemisiae Annuae 22.5 parts, Rhizoma Coptidis 4.5 parts, Herba Euphorbiae Humifusae 12.5 parts, Radix Sophorae Flavescentis 13 parts, eucalyptus leaves 21
Part, Radix Saposhnikoviae 7 parts, the Rhizoma Atractylodis Macrocephalae 13 parts, Plantula Papaveris 1.4 parts, Herba Pogostemonis 12 parts, 6.5 parts of Poria, Pericarpium Arecae 12 parts, Folium Perillae
10 parts, the Radix Angelicae Dahuricae 7.5 parts, Pericarpium Citri tangerinae 5.5 parts, Cortex Magnoliae Officinalis 5 parts, 10 parts of Radix Glycyrrhizae, Ramulus Cinnamomi 20 parts, roud cardamon seed 11 parts, gold hair
Auricled Hedyotis Herb 6 parts, the Radix Pulsatillae 10 parts, Caulis Lonicerae 6 parts；Described adjuvant component and weight portion be: Margarita powder 0.45 part, jelly powder
0.55 part, tannalbin 0.3 part, pepsin 0.015 part, polyzyme tablets 0.20 part, yeast tablet 0.03 part, lactic acid calcium powder
0.15 part, compound vitamin 4 parts；
Described compound vitamin is vitamin A, vitamin B2, ascorbic mixture；
The pharmaceutical composition of described treatment infantile enteritis is prepared by following methods, comprises the following steps:
(1) weigh Herba Asari, Herba Artemisiae Annuae, Herba Euphorbiae Humifusae, eucalyptus leaves, Folium Perillae, Pericarpium Arecae, Cortex Magnoliae Officinalis, the Radix Pulsatillae by formula ratio, adopt
With ethanol extract from water precipitation, alcohol reflux, filter, reclaim ethanol, separate to obtain extracting solution, then precipitate with pure water, remove miscellaneous
Matter, concentrate under reduced pressure at low temperature obtains the extractum that water content is 5-18%, standby；
(2) Rhizoma Coptidis, Radix Sophorae Flavescentis, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Plantula Papaveris, Herba Pogostemonis, Poria, the Radix Angelicae Dahuricae, Pericarpium Citri tangerinae, Radix Glycyrrhizae, osmanthus are weighed by formula ratio
Branch, roud cardamon seed, Hedyotis chrysotricha, Caulis Lonicerae, pulverize, and adds water to exceed 3-5 centimetre of medical material surface, and pressurized high-temperature extracts, military
Fire heated and boiled, changes low baking temperature and keeps slight boiling condition, extract 2-3 time, and each extraction time is 30-50 minute, filters, and merges
Extracting solution, is concentrated into the concentrated solution that water content is 40-50%, regulates PH to 5.0-7.0, by Ethanol Treatment, and precipitated impurities,
Again it is concentrated to give the extractum that water content is 5-20%, standby；
(3) weighing adjuvant by formula ratio, make solvent with pure water, after dissolving, the extractum prepared with step (2), (3) mixes, i.e.
Obtain the pharmaceutical composition of described treatment infantile enteritis.
The pharmaceutical composition for the treatment of infantile enteritis the most according to claim 1, it is characterised in that described treatment infantile enteritis
Pharmaceutical composition is syrup, oral liquid.
4. according to the preparation method of the pharmaceutical composition treating infantile enteritis one of claim 1-2 Suo Shu, it is characterised in that
Comprise the following steps:
(1) weigh Herba Asari, Herba Artemisiae Annuae, Herba Euphorbiae Humifusae, eucalyptus leaves, Folium Perillae, Pericarpium Arecae, Cortex Magnoliae Officinalis, the Radix Pulsatillae by formula ratio, adopt
With ethanol extract from water precipitation, alcohol reflux, filter, reclaim ethanol, separate to obtain extracting solution, then precipitate with pure water, remove miscellaneous
Matter, concentrate under reduced pressure at low temperature obtains the extractum that water content is 5-18%, standby；
(2) Rhizoma Coptidis, Radix Sophorae Flavescentis, Radix Saposhnikoviae, the Rhizoma Atractylodis Macrocephalae, Plantula Papaveris, Herba Pogostemonis, Poria, the Radix Angelicae Dahuricae, Pericarpium Citri tangerinae, Radix Glycyrrhizae, osmanthus are weighed by formula ratio
Branch, roud cardamon seed, Hedyotis chrysotricha, Caulis Lonicerae, pulverize, and adds water to exceed 3-5 centimetre of medical material surface, and pressurized high-temperature extracts, military
Fire heated and boiled, changes low baking temperature and keeps slight boiling condition, extract 2-3 time, and each extraction time is 30-50 minute, filters, and merges
Extracting solution, is concentrated into the concentrated solution that water content is 40-50%, regulates PH to 5.0-7.0, by Ethanol Treatment, and precipitated impurities,
Again it is concentrated to give the extractum that water content is 5-20%, standby；
(3) weighing adjuvant by formula ratio, make solvent with pure water, after dissolving, the extractum prepared with step (2), (3) mixes, i.e.
Obtain the pharmaceutical composition of described treatment infantile enteritis.
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| CN102048933A (en) * | 2010-12-20 | 2011-05-11 | 崔守凤 | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof |
| CN102258745A (en) * | 2011-06-16 | 2011-11-30 | 吴新治 | Antiviral antidiarrheal agent for treating autumn viral diarrhea and spleen-deficiency diarrhea in infants |
| CN102688438A (en) * | 2012-05-31 | 2012-09-26 | 柳玉勇 | Chinese medicinal orally disintegrating tablets for treating infantile diarrhea |
| CN103040975A (en) * | 2013-02-02 | 2013-04-17 | 崔合芳 | Traditional Chinese medicine composition for nursing and treating infantile diarrhea |
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| CN102048933A (en) * | 2010-12-20 | 2011-05-11 | 崔守凤 | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof |
| CN102258745A (en) * | 2011-06-16 | 2011-11-30 | 吴新治 | Antiviral antidiarrheal agent for treating autumn viral diarrhea and spleen-deficiency diarrhea in infants |
| CN102688438A (en) * | 2012-05-31 | 2012-09-26 | 柳玉勇 | Chinese medicinal orally disintegrating tablets for treating infantile diarrhea |
| CN103040975A (en) * | 2013-02-02 | 2013-04-17 | 崔合芳 | Traditional Chinese medicine composition for nursing and treating infantile diarrhea |
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