Background technology
Infantile diarrhea is divided into infectious and non-infectious two classes according to the cause of disease, be by many cause of diseases, multifactor cause take the one group clinical syndrome of diarrhoea as leading.Age of onset is many below 2 years old, accounts for 50% with interior person in 1 years old.Every day is died from the child of diarrhoea up to 5,000,000~1,800 ten thousand in the whole world.In China, infantile diarrhea is the 2nd commonly encountered diseases, the frequently-occurring disease that is only second to respiratory tract infection.General multiple summer, autumn are take warm, stagnant and intestinal infection as main.Infantile diarrhea has many reasons to cause, but basically fills the pass with wet, moreover tender and lovely, the spleen tending to insufficiency usually of children's's visceral peritoneum, in case internal damage caused by infantile dyspepsia, affection of exogenous wind-cold, makes dysfunction of spleen and stomach, can not digest breast and eat heresy of summer-heat, impairing the spleen and stomach.Make clear QI being mixed up with turbid QI, the large intestine of making a bet, and for having loose bowels.
Chinese invention patent: a kind of Chinese medicine composition (CN 100358549) for the treatment of diarrhoeal diseases discloses a kind of Chinese medicine formula: it is that raw material is made by Rhizoma Coptidis, Radix Scutellariae, the Radix Paeoniae Alba, Herba Pogostemonis, Folium Psidii Guajavae, Poria.It has the effect of heat-clearing and toxic substances removing, scorching antidiarrheal, but its course for the treatment of is long, generally needs cure in 3 days, and cure rate is also lower.
Chinese invention patent: a kind of Chinese medicine formula (application number 200910229336.4) for the treatment of infantile diarrhea discloses a kind of Chinese medicine formula for the treatment of infantile diarrhea, and this prescription is mainly filled a prescription and is comprised of Herba Pogostemonis, Poria, the Radix Angelicae Dahuricae, Folium Perillae, Pericarpium Citri Reticulatae, the stir-fry Radix Aucklandiae, Rhizoma Zingiberis Recens, Fructus Jujubae, Semen Coicis.This patent does not have to disclose the therapeutic effect of this invention.
Chinese invention patent: a kind of Chinese medicine for the treatment of infantile diarrhea and preparation method thereof (CN 101306177 B) discloses a kind of Chinese medicine for the treatment of infantile diarrhea and preparation method thereof, first with Poria, Semen Lablab Album, RHIIZOMA DIOSCOREAE fr0m Henan of China, Semen Coicis, Semen Nelumbinis, Radix Sanguisorbae, Semen Plantaginis, Rhizoma Coptidis is ground into fine powder after by above-mentioned weight proportion it being concocted, again with Fructus Mume, Radix Platycodonis, Radix Glycyrrhizae, Fructus Aurantii, the Radix Paeoniae Alba, Semen Myristicae, Fructus Amomi, the Radix Aucklandiae, Radix Scutellariae is fried in shallow oil it to concentrated solution by above-mentioned weight proportion, then with fine powder and its mixing and stirring pulverized, after lyophilization, grind as smalls and make powder.These patent flavour of a drug are many, and complicated, and preparation technology is loaded down with trivial details.
Existing marketed drugs Chinese medicine has Medilac-Vita, treating infant diarrhea speed to stop and the French dioctahedral smectite of winning the good fortune pharmacy, Medilac-Vita contains two kinds of viable bacterias: bacillus subtilis and enterococcus, can directly replenish the normal physiological flora, suppress pathogenic bacterium, promote digestion, the absorption of nutrient substance, suppress generation and the absorption of intestinal source property toxin, reach the purpose of adjusting dysbacteriosis in the intestinal, though this medication effect is good, the state of an illness easily repeatedly, radical rate is low.Rush down speed and stop by Herba Euphorbiae Humifusae, obtain Siberian cocklebur, Radix Glycyrrhizae, catechu etc. and form, have the effects such as clearing heat and expelling damp, invigorating the spleen to arrest diarrhea, dispel emphatically pathogen, repair deficiency recovers digestive and absorptive functions, but lacks the defencive function to gastrointestinal.Dioctahedral smectite mainly by to the gastrointestinal protection, stops bacterial virus in the gastrointestinal field planting, and cell is repaired as early as possible, the auxiliary reparation that suffers for want of medical supplies and adjusting humoral effect.
Summary of the invention
The Chinese medicine composition that the purpose of this invention is to provide a kind of invigorating the spleen and regulating the stomach, promoting diuresis to eliminate damp pathogen and middle antidiarrheal, highly effective and safe, wide adaptability is to solve the existing existing deficiency of Chinese medicine preparation.
The present invention is achieved through the following technical solutions for achieving the above object:
A kind of Chinese medicine composition for the nursing for treating infantile diarrhea of the present invention is made by the raw material of Chinese medicine of following weight portion: Pericarpium Granati 6-10 part, Pericarpium Mali pumilae 6-10 part, Endothelium Corneum Gigeriae Galli 4-6 part, Flos Caryophylli 3-6 part, Herba Agrimoniae 0.2-1.2 part, Herba Portulacae 6-9 part, Rhizoma Atractylodis Macrocephalae 3-6 part.
The present invention is used for the Chinese medicine composition of nursing for treating infantile diarrhea, is preferably made by the raw material of Chinese medicine of following weight portion: 10 parts of Pericarpium Granatis, 8 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.4 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes.
The Chinese medicine composition that the present invention is used for the nursing for treating infantile diarrhea can also comprise pharmaceutically acceptable adjuvant, such as glucose powder, edible or medicinal essence etc.
The Chinese medicine composition that the present invention is used for the nursing for treating infantile diarrhea can be made any peroral dosage form on the pharmaceutics, such as tablet, pill, powder, capsule etc., and preferred powder.
Side of the present invention separates:
Pericarpium Granati: be the peel of Punicaceae plant Punica granatum L..Sour in the mouth, puckery, warm in nature.Return large intestine channel.Function cures mainly: relieving diarrhea with astringents, killing parasites for relieving itching.Astringing intestine to stop diarrhea, hemostasis, anthelmintic.Control chronic diarrhea, chronic dysentery is had blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies." not Lu ": " treat dysentery, leak-stopping be smart." " property of medicine opinion ": " control muscles and bones wind, the waist foot is unsuccessful, the anxious pain of walking contraction.Main astringing intestine to stop diarrhea ends red white dysentery.Extracting juice ends under the order tear, controls Lou smart." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control with the passing of time watery diarrhea, simmer clothes with frying Saccharum Sinensis Roxb., control again the dysentery pus and blood, the large intestine hematochezia.Fry in shallow oil with Fructus Aristolochiae and to control children's's infantile malnutrition worm." " detailed outline ": " antidiarrheal dysentery, hematochezia, proctoptosis, metrorrhagia leukorrhagia." the existing clinical treatment that is commonly used to: bacillary dysentery, amebic dysentery and multi-infection inflammation.
Pericarpium Mali pumilae: be the peel of rosaceous plant Fructus Mali pumilae; Nature and flavor are sweet; Cool.Gui Jing: stomach warp.Function cures mainly: normalizing the stomach by guiding QI downward.Main regurgitation." this sketch of the southern regions of the Yunnan Province is said ": control regurgitation and spit.
Endothelium Corneum Gigeriae Galli: be the dry gizzard inwall (muscular stomach) of Chordata Phasianidae animal man chicken.Nature and flavor are sweet, and are flat.Be included into the taste warp.The promoting digestion and invigorating the stomach activating the spleen, dissipating blood stasis fossil, arresting seminal emission." Records of Tradition Chinese and Western Medicine in Combination ": Endothelium Corneum Gigeriae Galli, the taste of chicken also, in have porcelain stone, copper, ferrum all can digest, its kindization alluvial, placed in the middle burnt with the lifting gasification, if alluvial is arranged, gasification can not lifting, is easily to cause distension, is organotherapy with Endothelium Corneum Gigeriae Galli, if again with the Rhizoma Atractylodis Macrocephalae etc. and usefulness, be the key medicine of digestion alluvial, the more quality goods of tonifying the spleen and stomach, taste are healthy and strong, benefit can the transporting efficacy of a drug with removing food stagnancy also, not only can the diabetes with polyphagia as the prominent symptom stomach long-pending, no matter where internal organs have long-pendingly, and Endothelium Corneum Gigeriae Galli all can disappear it.
Flos Caryophylli: suffering, temperature." Kaibao Bencao ": " acrid in the mouth, temperature, nontoxic." enter stomach, spleen, kidney channel.Materia Medica of Decoction: " lunar, bright, the shaoyin channel of foot sun of starting with." " Thunder God is concocted property of medicine solution ": " enter lung, spleen, stomach, kidney four warps." " book on Chinese herbal medicine is newly organized ": " Flos Caryophylli has female, male dividing, and in fact cures the disease without dividing each other.Acrid in the mouth, temperature, pure sun is nontoxic.Enter kidney, stomach two warps, walk again lunar lungs." function cures mainly: warming middle-JIAO to send down the adverse QI, pain relieving cure mainly coldness and pain in the epigastrium, and vomiting is had loose bowels.Containing volatile oil is Oleum Caryophylli.Bacillus pestis, vibrio cholera, anthrax bacillus, dysentery bacterium, escherichia coli there is inhibitory action.
Herba Agrimoniae: nature and flavor are bitter, hot." BAICAO mirror " carries, and " therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness." " medicine mirror pick up any lost article from the road tax ": " and roll the expectorant of pharynx diaphragm, the sound of vomiting of flat regurgitation of food from the stomach, the bitter in the mouth suffering is put down into lungs, wears intestinal and wears stomach and can assault fortified position, and collects stem and leaf and smashes juice usefulness, and the cane-juice spirit assistant makes complete, expectorant verticalization of dysphagic drink, Tianjin is swallowed and is calmed down merit at first.No matter " men and women, old and young, abdominal distention diarrhoea there is specially good effect with it.
Herba Portulacae: another name long life dish, longevity greens/mustard green, five elements' grass, hornet dish, horse horse dish.Cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Effect: heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic.Cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia was had blood in stool, the diseases such as mastitis.Loose blood detumescence, sharp intestinal habitual abortion, it is treating stranguria to detoxify, the rear sweating due to debility of managing property.The Herba Portulacae stem and leaf contains nicotinic acid, Saponin, tannin, carbamide etc., and broad-spectrum antibacterial action is arranged, and dysentery, typhoid fever etc. is had preferably effect.Experiment in vitro, Herba Portulacae has inhibition or killing action to various dysentery bacterium.Clinical report, Herba Portulacae all have good result to various bacterial dysentery and suppurative illness.
The Rhizoma Atractylodis Macrocephalae: another name mountain Ji, poplar Serrata Ji, art, yellor rocket, day Ji, Alpinia japonica (Thunb.) Miq., Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis Macrocephalae, QI LI JIA, the winter Rhizoma Atractylodis Macrocephalae.Perennial herb is used as medicine with rhizome, has multinomial medicinal function.Effect: invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
The present invention also provides the preparation method of the Chinese medicine composition of described treatment infantile diarrhea, comprises following steps: take by weighing each component by above-mentioned weight portion, cross 120 mesh sieves after pulverizing, and mix homogeneously, sterilization is distributed into bottle, makes powder of the present invention.
The Chinese medicine composition that the present invention is used for the nursing for treating infantile diarrhea compared with prior art has the following advantages:
1, curative effect is fast, can cure in general one day, and cure rate can reach more than 98 ﹪, and non-relapse after healing;
2, flavour of a drug are few, and raw material is without in great shortage, and is cheap and easy to get, and preparation technology is simple;
3, the present invention is that pure Chinese medicinal preparation, dosage are few, is convenient to the child and takes, and has no side effect;
4, all medicine 5 usefulness of the present invention can increase child's immunity of organisms.
For further investigating clinical efficacy and the safety of medicine of the present invention, select 100 routine infantile diarrhea patients that the curative effect of medicine of the present invention has been carried out clinical observation.
60 routine cases are divided into two groups at random, treatment group 60 examples, matched group 40 examples.Case all according to the diagnostic criteria of " disease of tcm Standardization of diagnosis and curative effect ", is diagnosed as infantile diarrhea.
Diagnostic criteria:
1. times of defecation increases, and nearly more than 10 times, is faint yellow every day 3-5 time, and such as egg soup sample, or color is brown and smelly, and a small amount of mucus can be arranged.Or with feeling sick, vomiting, stomachache, heating thirstyly waits disease;
2. excess in feeding is arranged, unhygienic diet or experience the medical history of seasonal pathogen;
3. severe one diarrhoea and vomiting be than severe patient, visible oliguria, fervescence, excessive thirst god withers, skin is shrivelled, sunken fontanel, the order pearl is sunk, crying without tears, the lip cherry is red, breathe profound, the diseases such as abdominal distention;
4. the stool microscopy can have Oil globule, a small amount of red white corpuscle;
5. the stool pathogenic examination can have the growths such as Escherichia coli, or separates rotavirus etc.;
6. severe diarrhea has dehydration, acid base imbalance and electrolyte disturbance;
Therapeutic Method
Matched group adopts dioctahedral smectite, and is oral, the child: below 1 years old, 1 bag of every day, take minutes for 3 times: 1-2 year: every day the 1-2 bag, take minutes for 3 times, more than 2 years old: every day the 2-3 bag, take minutes for 3 times.The powder agent medicine that treatment group adopts Chinese medicinal composition preparation embodiment 1 of the present invention to make is treated, below 1 years old, and every day 3 times, each 2 grams.1-2 year: every day 3 times, each 3 grams.More than 2 years old: every day 3 times, each 4 grams.7 days is a course for the treatment of.
Criterion of therapeutical effect
" subproposal of diarrhoeal diseases curative effect judging standard " according to the revision of the whole nation, Beijing in 1998 organizing committee of diarrhoea prevention scientific seminar formulates following the standard of curative effect evaluation:
Cure:
Treat in 2 days, the diarrhoea number of times reduces in 3 times, diarrhoea total amount<150ml, and feces shape and number of times recover normal in 3 days, and General Symptoms disappears.
Effectively:
In the medication 2 days, the diarrhoea number of times reduces in 5 times, diarrhoea total amount<250ml, and feces shape and number of times are clearly better in 3 days, and General Symptoms obviously improves.
Invalid:
In the medication 2 days, diarrhoea number of times still more than 5 times, diarrhoea total amount>300 ml, excrement shape, number of times and General Symptoms are without being clearly better to deterioration in 3 days.
Total effective rate n(%)=recovery from illness n(%)+effective n(%)
The curative effect comparative result sees Table 1 after two groups of case treatments.
Curative effect relatively after the table 1 liang group case treatment
Group |
The example number |
Recovery from illness n(%) |
Effective n(%) |
Invalid n(%) |
Total effective rate n(%) |
Matched group |
40 |
21(52.5) |
10(25) |
9(22.5) |
31(77.5) |
Treatment group |
60 |
49(81.7) |
10(16.7) |
1(1.7) |
59(98.3) |
Statistical result showed, the treatment group curative effect obviously is better than matched group, and two group differences are remarkable, p<0.05.Through the clinical experiment checking, Chinese medicine composition group of the present invention can be fully recovered in general two days, and cure rate can reach more than 80% in two days, and total effective rate can reach 98.3%.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting protection scope of the present invention.
Example of formulations 1:
The present invention is used for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the raw material configuration by following weight portion forms: 10 parts of Pericarpium Granatis, 8 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.4 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes.
Its preparation process is as follows: take by weighing each component by above-mentioned weight, cross 120 mesh sieves after pulverizing, mix sterilization, be distributed into bottle, make powder of the present invention.
Example of formulations 2
The present invention is used for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the raw material configuration by following weight portion forms: 6 parts of Pericarpium Granatis, 6 parts of Pericarpium Mali pumilaes, 4 parts of Endothelium Corneum Gigeriae Galli, 3 parts of Flos Caryophyllis, 0.2 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 3 parts of the Rhizoma Atractylodis Macrocephalaes.
Its preparation process is as follows: take by weighing each component by above-mentioned weight, cross 120 mesh sieves after pulverizing, mix sterilization, be distributed into bottle, make powder of the present invention.
Example of formulations 3
The present invention is used for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the raw material configuration by following weight portion forms: 10 parts of Pericarpium Granatis, 10 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 6 parts of Flos Caryophyllis, 1.2 parts of Herba Agrimoniaes, 9 parts of Herba Portulacaes, 6 parts of the Rhizoma Atractylodis Macrocephalaes.
Its preparation process is as follows: take by weighing each component by above-mentioned weight, cross 120 mesh sieves after pulverizing, mix sterilization, be distributed into bottle, make powder of the present invention.
Example of formulations 4
The present invention is used for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the raw material configuration by following weight portion forms: 10 parts of Pericarpium Granatis, 8 parts of Pericarpium Mali pumilaes, 4 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.6 part of Herba Agrimoniae, 8 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes.
Its preparation process is as follows: take by weighing each component by above-mentioned weight, cross 120 mesh sieves after pulverizing, mix sterilization, be distributed into bottle, make powder of the present invention.
Example of formulations 5
The present invention is used for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the raw material configuration by following weight portion forms: 10 parts of Pericarpium Granatis, 8 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.4 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of glucoses.
Its preparation process is as follows: take by weighing each component by above-mentioned weight, cross 120 mesh sieves after pulverizing, mix sterilization, be distributed into bottle, make powder of the present invention.
Example of formulations 6
The present invention is used for the Chinese medicine composition of nursing for treating infantile diarrhea, is that the raw material configuration by following weight portion forms: 10 parts of Pericarpium Granatis, and 8 parts of Pericarpium Mali pumilaes, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Flos Caryophyllis, 0.4 part of Herba Agrimoniae, 6 parts of Herba Portulacaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes, edible essence is an amount of.
Its preparation process is as follows: take by weighing each component by above-mentioned weight, cross 120 mesh sieves after pulverizing, mix sterilization, be distributed into bottle, make powder of the present invention.