CN103784851A - Traditional Chinese medicinal preparation for treating Meniere's disease and preparation method thereof - Google Patents
Traditional Chinese medicinal preparation for treating Meniere's disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal preparation for treating Meniere's disease and a preparation method thereof, belonging to the field of traditional Chinese medicine. The traditional Chinese medicinal preparation comprises the following effective components: Cryptotympana pustulata slough, Radix Polygalae (Polygala tenuifolia and/or Polygala sibirica), Cornus officinalis, Semen Cassiae (Cassia obtusifolia and/or Cassia tora), Aeschynomene indica root, Polygonatum odoratum, Aristolochia cathcartii, Fructus Amomi Rotundus (Amomum kravanh and/or Amomum compactum), Leersia hexandra, Micromeria biflora, Akebia quinata, Lycoris radiata, Ziziphus jujuba (Semen Ziziphi Spinosae), Angelica dahurica, Perilla frutescens and Acorus calamus. The traditional Chinese medicinal preparation of the invention has reasonable formulation which meets the theory of traditional traditional Chinese medicine and modern medicine research, has effects of suppressing hyperactive liver for calming endogenous wind, promoting the circulation of qi and relieving stagnation, can treat different symptoms of Meniere's disease, can thoroughly cure Meniere's disease, and has the advantages of no recurrence, good safety and no adverse effects, and fills in the blank of Meniere's disease drugs.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of Chinese medicine preparation and preparation method for the treatment of Menieres disease.
Background technology
Menieres disease is a kind of disease of inner ear with hydrolabyrinth.Primary disease is take the vexed swollen sense of rotatory vertigo, undulatory property auditory dysesthesia, tinnitus ear of sudden outbreak repeatedly and nystagmus as main clinical manifestation, and dizzy have obvious stage of attack and an intermission.Primary disease is multiple be born in 30～50 years old in, adolescence, child is rare.Men and women falls ill without significant difference.Ears are suffered from patient and are accounted for 10%～50%.
The cause of disease of Menieres disease is still indefinite at present, talks about publicly diverse and confused.The known cause of disease comprises following factor at present: various infective agents (antibacterial, virus etc.), damage (comprising mechanical injuries or acoustic trauma), otosclerosis, syphilis, inherited genetic factors, allergy, tumor, leukemia and autoimmune disease etc.
Between Menieres disease stage of attack patient open eyes or rotation head symptom can increase the weight of, repose therefore most patient is closed order, head and health all dare not rotate.There is one-sided tinnitus and deafness in most patients, minority is bilateral in the time of outbreak.Approximately 25% patient is existing tinnitus and deaf appearance before outbreak, and in outbreak postemphasis.Stage of attack transfers the intermission to two kinds of forms: one is dizzy and simultaneous phenomenon suddenly disappears, and one is dizzyly to gradually become giddy and disappear gradually.The intermission of Meniere is different in size, and from several months to several years, each outbreak and degree are also different.And audition is faded along with the increase of attack times, finally cause deafness.
Because the Meniere cause of disease and pathogenesis are not clear, there is no at present the Therapeutic Method that makes primary disease recovery from illness.Many employings at present regulate autonomic nervous function, improve inner ear microcirculation, remove hydrolabyrinth is main Drug therapy and operative treatment.Because Drug therapy and operative treatment can only play mitigation, can not fundamentally treat disease, disease has been brought huge puzzlement to patient's life, and impact is life normally, and develop a kind of medicine that can treat Menieres disease has become research topic important in medical history for this reason.
Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of Menieres disease; The selected Chinese crude drug compatibility of Chinese medicine preparation of the present invention is suitable, meet Chinese medicine and modern medicine and pharmacology research theory, there is effect of suppressing the hyperactive liver to relieve the wind syndrome, activating QI to alleviate the depression, can treat all kinds of symptoms that Meniere syndrome causes, and thorough cure diseases, more after, do not recur, safety have no side effect, filled up cure U.S. Neil formula syndrome medicament blank.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for Menieres disease, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
30～55 parts of 30～60 parts of Semen Cassiaes of 30～60 portions of Fructus Evodiaes of 40～70 parts of Radix Polygalaes of Periostracum Cicadae
20～45 parts, 20～50 parts of Fructus Amomi Rotunduss of 25～50 parts of Fructus Aristolochiae Kwangsiensiss of 25～55 portions of Rhizoma Polygonati Odorati of Radix Aeschynomenes indicae
10～45 parts of 15～45 portions of Bulbus Lycoridis Radiataes of 15～45 parts of Fructus Akebiaes of 20～45 parts of Herba Micromeriae Bifloraes of Herba leerisae hexandrae
6～30 parts of 8～35 parts of Rhizoma Acori Calami of 8～40 parts of Radix Perillae of 10～40 parts of Radixs Angelicae Dahuricae of Semen Ziziphi Spinosae.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
34～51 parts of 35～55 parts of Semen Cassiaes of 35～55 portions of Fructus Evodiaes of 45～65 parts of Radix Polygalaes of Periostracum Cicadae
24～41 parts, 25～45 parts of Fructus Amomi Rotunduss of 29～46 parts of Fructus Aristolochiae Kwangsiensiss of 30～50 portions of Rhizoma Polygonati Odorati of Radix Aeschynomenes indicae
16～39 parts of 20～40 portions of Bulbus Lycoridis Radiataes of 20～40 parts of Fructus Akebiaes of 24～41 parts of Herba Micromeriae Bifloraes of Herba leerisae hexandrae
10～26 parts of 12～31 parts of Rhizoma Acori Calami of 13～35 parts of Radix Perillae of 15～35 parts of Radixs Angelicae Dahuricae of Semen Ziziphi Spinosae.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
39～47 parts of 40～50 parts of Semen Cassiaes of 40～50 portions of Fructus Evodiaes of 50～60 parts of Radix Polygalaes of Periostracum Cicadae
28～37 parts, 30～40 parts of Fructus Amomi Rotunduss of 33～42 parts of Fructus Aristolochiae Kwangsiensiss of 35～45 portions of Rhizoma Polygonati Odorati of Radix Aeschynomenes indicae
22～33 parts of 25～35 portions of Bulbus Lycoridis Radiataes of 25～35 parts of Fructus Akebiaes of 28～37 parts of Herba Micromeriae Bifloraes of Herba leerisae hexandrae
14～22 parts of 16～27 parts of Rhizoma Acori Calami of 18～30 parts of Radix Perillae of 20～30 parts of Radixs Angelicae Dahuricae of Semen Ziziphi Spinosae.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
43 parts of 45 parts of Semen Cassiaes of 45 portions of Fructus Evodiaes of 55 parts of Radix Polygalaes of Periostracum Cicadae
33 parts, 35 parts of Fructus Amomi Rotunduss of 38 parts of Fructus Aristolochiae Kwangsiensiss of 40 portions of Rhizoma Polygonati Odorati of Radix Aeschynomenes indicae
28 parts of 30 portions of Bulbus Lycoridis Radiataes of 30 parts of Fructus Akebiaes of 33 parts of Herba Micromeriae Bifloraes of Herba leerisae hexandrae
18 parts of 21 parts of Rhizoma Acori Calami of 24 parts of Radix Perillae of 25 parts of Radixs Angelicae Dahuricae of Semen Ziziphi Spinosae.
Treat a preparation method for the Chinese medicine preparation of Menieres disease, comprise following processing step:
(1) by Periostracum Cicadae, Semen Cassiae, Fructus Aristolochiae Kwangsiensis, Semen Ziziphi Spinosae and the Radix Angelicae Dahuricae with mix, after mix homogeneously, carry out pulverization process, grind into powder, cross 160 order fine powders, for subsequent use;
(2) Radix Polygalae, Radix Aeschynomenes indicae, Herba leerisae hexandrae, Herba Micromeriae Biflorae, Radix Perillae and Rhizoma Acori Calami are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.12～1.17, for subsequent use;
(3) Fructus Evodiae and Bulbus Lycoridis Radiatae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) Rhizoma Polygonati Odorati, Fructus Amomi Rotundus and Fructus Akebiae are cleaned, immersed 70% the alcohol solution dipping 1～2 hour of 3 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 60 ℃ of simmer down tos, relative density is 1.11～1.15, for subsequent use;
(5) above-mentioned steps (1)～(4) prepared fine powder, thick paste and juice are mixed, make tablet or capsule, obtain the Chinese medicine preparation for the treatment of Menieres disease of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Periostracum Cicadae: sweet in the mouth, cold in nature; Return lung, Liver Channel.Loose wind heat extraction, sore-throat relieving rash, nebula removing spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, convulsion with spasms, tetanus." detailed outline " carries: " control phlegm-accumulating vertigo, skin wind heat, varioliform exanthema is had an itch, tetanus and treatment toxic swelling skin ulcer, adult's aphonia, children's's lockjaw sky hangs, the frightened night cry of crying, swelling of the vulva.”
Radix Polygalae: bitter in the mouth, pungent, warm in nature; GUIXIN, kidney, lung meridian.The Fructus Alpiniae Oxyphyllae of calming the nerves, eliminating phlegm for diminishing swelling.The insomnia and dreamful sleep, the forgetful palpitation with fear that cause for disarmony between the heart and kidney, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain." Mingyi Bielu " carries: " centering gas, spasmolytic is throbbed with fear, and benefit essence goes heat in heart intake of food in the morning and vomitting in the evening gas, skin, appearance yellow.”
The Fructus Evodiae: sour-puckery flavor, slightly warm in nature; Enter liver, stomach warp.Invigorating the liver and kidney, arresting seminal emission gas, Gu collapse, stomach invigorating tonifying YANG.The traditional Chinese medical science is conventional with treatment soreness of waist and knee joint, dizzy, tinnitus, and seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse, neurasthenia, the diseases such as menoxenia.Modern medicine study confirmation, the Fructus Evodiae can suppress dysentery bacterium, Bacillus typhi, golden yellow puckery staphylococcus and some dermatophytes, has diuresis, blood pressure lowering, protective effect on cancer risk.
Semen Cassiae: sweet in the mouth, hardship, salty, cold nature; Return liver, large intestine channel.Clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, headache Menieres disease, poor vision, constipation." Japan hanako materia medica " carries: " help irritability, beneficial smart water; Adjust end to be coated with, detumescence poison, Xie temple are controlled headache, paste again the brain heart and stop epistaxis; Make pillow victory Semen sojae atricolor, control wind syndrome of head, improving eyesight.”
Radix Aeschynomenes indicae: sweet in the mouth, cold in nature; Return lung, stomach, urinary bladder channel.Clearing away heat-damp and promoting diuresis, removing food stagnancy removing toxic substances.Cure mainly stranguria with blood, have loose bowels, dysentery, infantile malnutrition, blurred vision, toothache, furuncle." Jiangxi medical herbs ": " clearing away heat-damp and promoting diuresis, detumescence hemostasis.”
Rhizoma Polygonati Odorati: sweet in the mouth, property is flat; Enter lung, stomach warp.Nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.Cure mainly cough caused by dryness, chronic cough, the dry throat and mouth of the cloudy liquid consumption of calentura wound, interior-heat is quenched one's thirst, and deficiency of YIN diseases caused by exogenous pathogenic factor are dizzy dizzy, muscle arteries and veins spasm and pain.Supplement to the Herbal carries: " main clever, adjust vim and vigour, make us strong." modern medicine study confirms, tonification the five internal organs, nourish QI and blood, and flat benefit and moistening held concurrently except effect of wind heat.
Fructus Aristolochiae Kwangsiensis: bitter in the mouth, cold in nature; Return stomach warp.Heat-clearing and toxic substances removing, regulating QI to relieve pain, relaxing muscles and tendons and activating QI and blood in the collateral.For acute gastroenteritis, Stomach duodenum ulcer, pharyngolaryngitis, pulmonary tuberculosis, ulcer sore pain, stomachache, abdominalgia with intestinal abscess, rheumatic arthralgia, treating swelling and pain by traumatic injury." Guangxi medicine is planted register " carries: " refrigerant bringing down a fever, removing toxic substances.Control dizziness, laryngalgia, gastropathy, stomachache, skin ulcer scabies, knife injury, snakebite.”
Fructus Amomi Rotundus: acrid in the mouth, hot in nature; Return lung, spleen, stomach warp.Cold expelling dampness, alcoholic intoxication, the removing dampness painful abdominal mass that disappears, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving.For turbid damp obstructing in middle-JIAO, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, cold-damp vomiting, chest and abdomen swelling and pain, food stagnation does not disappear." book on Chinese herbal medicine is original " carries: " tonifying the spleen and stomach, mill is stagnant, adjusts very speed of cold scattering gas, and it is the most suitable that weakness can not be drunk trencherman, the alcoholic intoxication of holding concurrently.”
Herba leerisae hexandrae: taste is flat, and property is pungent.Dispelling wind to relieve the exterior syndrome, dampness removing, removing obstruction in the collateral to relieve pain.Cure mainly flu, headache body pain, malaria, leucorrhea, lower limbs edema, dysuria, arthralgia pain numbness." Traditional Chinese Medicine in Sichuan will " carries: " energy expelling cold and relieving exterior syndrome, the meridian dredging.Treating malaria disease, flu head-body-pain.”
Herba Micromeriae Biflorae: bitter in the mouth, pungent, warm in nature.Expelling cold and relieving exterior syndrome, wet middle stomach invigorating, removing dampness removing food stagnancy.Cure mainly anemofrigid cold, pain relieving, cold syndrome of the stomach gastralgia, abdominal distention, nausea and vomiting, dysphagic, stomachache, stomachache, has loose bowels, dysentery, lump in the abdomen, colic of cold type." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " dry spleen warming the stomach, enters diet, the alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards.Treat nine kinds of gastric qi pain, the cold pain of face, chest and diaphragm flatulence, tripe abdomen cold type of pain, vomiting is felt sick, dysphagic regurgitation of food from the stomach, five kinds of masses in the chest and abdomen six is poly-, mass in the abdomen pain, man's colic of cold type trace pain, gynecological mass in abdomen becomes pain.”
Fructus Akebiae: sweet in the mouth, cold in nature; Return liver, stomach, urinary bladder channel.Liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Cure mainly stomachache due to hyperactive liver-QI attacking the stomach, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, cave warp, uterus tenesmus." Shaanxi Chinese herbal medicine " carries: " Shugan Yishen, invigorating the spleen and regulating the stomach.Control dyspepsia, stomachache, dysentery, hernia, uterus tenesmus.”
Bulbus Lycoridis Radiatae: acrid in the mouth, sweet, warm in nature, poisonous.Eliminate the phlegm emetic, detoxicating and resolving stagnation of pathogens.Cure mainly acute throat trouble, single bilateral tonsillitis, laryngopharynx swelling and pain, sputum is jammed, alimentary toxicosis, breast abdomen hydrops, malignant boil toxic swelling, sucutaneous nodule scrofula, anal fistula, traumatic injury, rheumatic arthritis, stubborn dermatitis, burn and scald, venom.
Semen Ziziphi Spinosae: sweet in the mouth, acid, property is flat; GUIXIN, spleen, liver, gallbladder meridian.Mind tranquilizing and the heart calming, nourishing the liver arresting sweating.For deficiency of YIN-blood, severe palpitation, insomnia forgetfulness, the empty hyperhidrosis of body." not Lu " carries: " main vexatious must not eye, umbilicus is pain up and down, blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, hard muscles and bones, helps cloudy gas, makes us fertile strong.”
The Radix Angelicae Dahuricae, acrid in the mouth, warm in nature; Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.For soft tissue contusion, hyperosteogeny, muscular strain, rheumatic myositis, fracture, costal chondritis, scapulohumeral periarthritis, the treatment of the diseases such as intercostal neuralgia.The Radix Angelicae Dahuricae all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.
Radix Perillae: acrid in the mouth, warm in nature, nontoxic; Enter lung, spleen two warps.Expelling wind and cold, lowering the adverse-rising QI and dispelling phlegm, and in antiabortive.Cure mainly dizziness, general pain, nasal obstruction watery nasal discharge, cough with dyspnea, septum pectorale drink, costalgia uncomfortable in chest, stomachache is had loose bowels, vomiting during pregnancy, frequent fetal movement." Traditional Chinese Medicine in Sichuan will " carries: " expelling wind, dissipating cold, sending down the abnormal ascending QI eliminates the phlegm.Control cough with dyspnea, chest and diaphragm phlegm retention, dizzy general pain and nasal obstruction watery nasal discharge.”
Rhizoma Acori Calami: acrid in the mouth, hardship, warm in nature; GUIXIN, liver, stomach warp.Waking up the patient from unconsciousness by dissipating phlegm, dehumidifying stomach invigorating, killing parasites for relieving itching.Cure mainly coma due to phlegm syncope, apoplexy, epilepsy, palpitates with fear forgetful, Hiccough and deaf, abdominal pain due to retention of food, dysentery is had loose bowels, rheumatalgia, eczema, scabies.
The present invention compared with prior art, has following beneficial effect:
The selected Chinese crude drug compatibility of Chinese medicine preparation of the present invention is suitable, meet Chinese medicine and modern medicine and pharmacology research theory, there is effect of suppressing the hyperactive liver to relieve the wind syndrome, activating QI to alleviate the depression, can treat all kinds of symptoms that Meniere syndrome causes, and thorough cure diseases, more after, do not recur, safety have no side effect, filled up cure U.S. Neil formula syndrome medicament blank.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Periostracum Cicadae 65g Radix Polygalae 55g Fructus Evodiae 55g Semen Cassiae 51g
Radix Aeschynomenes indicae 50g Rhizoma Polygonati Odorati 46g Fructus Aristolochiae Kwangsiensis 45g Fructus Amomi Rotundus 41g
Herba leerisae hexandrae 41g Herba Micromeriae Biflorae 40g Fructus Akebiae 40g Bulbus Lycoridis Radiatae 39g
Semen Ziziphi Spinosae 35g Radix Angelicae Dahuricae 35g Radix Perillae 31g Rhizoma Acori Calami 26g.
The preparation method of Chinese medicine preparation of the present invention, comprises following processing step:
(1) by Periostracum Cicadae, Semen Cassiae, Fructus Aristolochiae Kwangsiensis, Semen Ziziphi Spinosae and the Radix Angelicae Dahuricae with mix, after mix homogeneously, carry out pulverization process, grind into powder, cross 160 order fine powders, for subsequent use;
(2) Radix Polygalae, Radix Aeschynomenes indicae, Herba leerisae hexandrae, Herba Micromeriae Biflorae, Radix Perillae and Rhizoma Acori Calami are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.12～1.17, for subsequent use;
(3) Fructus Evodiae and Bulbus Lycoridis Radiatae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) Rhizoma Polygonati Odorati, Fructus Amomi Rotundus and Fructus Akebiae are cleaned, immersed 70% the alcohol solution dipping 1～2 hour of 3 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 60 ℃ of simmer down tos, relative density is 1.11～1.15, for subsequent use;
(5) above-mentioned steps (1)～(4) prepared fine powder, thick paste and juice are mixed, make tablet or capsule, obtain the Chinese medicine preparation for the treatment of Menieres disease of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2 (every 0.5g), warm water delivery service after meal; Within 5 days, be 1 course for the treatment of, can fully recover 2～3 courses for the treatment of, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.Embodiment 2
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Periostracum Cicadae 60g Radix Polygalae 50g Fructus Evodiae 50g Semen Cassiae 47g
Radix Aeschynomenes indicae 45g Rhizoma Polygonati Odorati 42g Fructus Aristolochiae Kwangsiensis 40g Fructus Amomi Rotundus 37g
Herba leerisae hexandrae 37g Herba Micromeriae Biflorae 35g Fructus Akebiae 35g Bulbus Lycoridis Radiatae 33g
Semen Ziziphi Spinosae 30g Radix Angelicae Dahuricae 30g Radix Perillae 27g Rhizoma Acori Calami 22g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.Embodiment 3
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Periostracum Cicadae 45g Radix Polygalae 35g Fructus Evodiae 35g Semen Cassiae 35g
Radix Aeschynomenes indicae 30g Rhizoma Polygonati Odorati 30g Fructus Aristolochiae Kwangsiensis 25g Fructus Amomi Rotundus 25g
Herba leerisae hexandrae 25g Herba Micromeriae Biflorae 20g Fructus Akebiae 20g Bulbus Lycoridis Radiatae 15g
Semen Ziziphi Spinosae 15g Radix Angelicae Dahuricae 13g Radix Perillae 13g Rhizoma Acori Calami 11g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.Embodiment 4
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Periostracum Cicadae 50g Radix Polygalae 40g Fructus Evodiae 40g Semen Cassiae 39g
Radix Aeschynomenes indicae 35g Rhizoma Polygonati Odorati 33g Fructus Aristolochiae Kwangsiensis 30g Fructus Amomi Rotundus 28g
Herba leerisae hexandrae 28g Herba Micromeriae Biflorae 25g Fructus Akebiae 25g Bulbus Lycoridis Radiatae 22g
Semen Ziziphi Spinosae 20g Radix Angelicae Dahuricae 18g Radix Perillae 16g Rhizoma Acori Calami 14g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.Embodiment 5
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Periostracum Cicadae 45g Radix Polygalae 35g Fructus Evodiae 35g Semen Cassiae 34g
Radix Aeschynomenes indicae 30g Rhizoma Polygonati Odorati 29g Fructus Aristolochiae Kwangsiensis 25g Fructus Amomi Rotundus 24g
Herba leerisae hexandrae 24g Herba Micromeriae Biflorae 20g Fructus Akebiae 20g Bulbus Lycoridis Radiatae 16g
Semen Ziziphi Spinosae 15g Radix Angelicae Dahuricae 13g Radix Perillae 12g Rhizoma Acori Calami 10g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of Menieres disease, the routine clinical observation of Menieres disease patient 200 that selection is made a definite diagnosis, patient is divided into two groups for the treatment of group and matched groups, treatment group 100 examples, wherein male's 55 examples at random, women's 45 examples, 50～75 years old age, 62.5 years old mean age, the shortest person of the course of disease 6 months, elder 8 years, average 4.1 years.Matched group 100 examples, wherein male's 54 examples, women's 46 examples, 51～76 years old age, 63.7 years old mean age, the shortest person of the course of disease 5 months, elder 7 years, average 3.8 years.
The course of disease, the degrees of symptoms for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group is taken Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2 (every 0.5g), warm water delivery service after meal; Within 5 days, be 1 course for the treatment of, take continuously 2～3 courses for the treatment of, the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Matched group is taken metoclopramide sheet, oral, be grown up one time 1～2,3 times on the one, every day 3 times, 30 minutes before the meal clothes, 6 days are 1 course for the treatment of, 1 course for the treatment of of the lighter, take continuously 2～3 courses for the treatment of can, the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
3, efficacy determination:
(1) cure: the sudden clinical symptom disappearance such as the vexed swollen sense of rotatory vertigo, undulatory property auditory dysesthesia, tinnitus ear and nystagmus of outbreak repeatedly, without rebound phenomenon, it is normal that patient body recovers.
(2) effective: above-mentioned symptom disappears substantially, without the sign that repeatedly shows effect.
(3) effective: above-mentioned symptom is alleviated to some extent.
(4) invalid: after patient takes medicine, symptom is without obvious change.
4, result:
Select in the treatment group of Chinese medicine preparation of the present invention, cure 40 examples, effective 30 examples, effective 26 examples, invalid 4 examples, cure rate 40%, total effective rate 96%.
In matched group, cure 10 examples, effective 20 examples, effective 30 examples, invalid 40 examples, cure rate 10%, total effective rate 60%.
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is given an example:
1, Wei, man, 53 years old, people from Xuzhou.Patient has a dizzy spell for many years, often looks thing rotation, companion's nausea and vomiting, Hiccough and deaf, sweating, pale complexion, repeatedly outbreak.Take after 2 courses for the treatment of of Chinese medicine preparation of the present invention, the symptoms such as dizzy, tinnitus, deafness slightly alleviate, and do not occur nausea and vomiting phenomenon, and sweating due to debility phenomenon disappears, then takes after 1 course for the treatment of, transference cure, and complexion is normal.
2, poplar, female, 65 years old, Taiyuan, Shanxi people.Patient is dizzy from recurrent dizziness the year before, blurred vision, tinnitus companion sweating above the waist, more than night without obviously inducement morbidity, morbidity in every 4～5 days 1 time, each lasting approximately 10～20 minutes, ignore thing rotation and the tending to vomit of feeling sick, when morbidity, sweating above the waist increases, awareness of defecation strengthens even fecal incontinence, has a strong impact on patient and household's thereof life.The body of being admitted to hospital is looked into as Menieres disease.To our hospital afterwards, take Chinese medicine preparation of the present invention, to take after 1 course for the treatment of, above-mentioned symptom alleviates, and takes after the 2nd course for the treatment of, and symptomatology disappears, and follows up a case by regular visits to not recurrence after 1 year.
3, Zhang, man, 71 years old, Jinan, Shandong Province people.Patient has a dizzy spell, and depending on thing running, closes order and stops.To our hospital afterwards, take Chinese medicine preparation of the present invention, to take after 1 course for the treatment of, the symptom of having a dizzy spell disappears substantially, continues to take after 1 course for the treatment of, and transference cure, follows up a case by regular visits to not recurrence after half a year.
Claims (5)
1. a Chinese medicine preparation for the treatment of Menieres disease, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
30～55 parts of 30～60 parts of Semen Cassiaes of 30～60 portions of Fructus Evodiaes of 40～70 parts of Radix Polygalaes of Periostracum Cicadae
20～45 parts, 20～50 parts of Fructus Amomi Rotunduss of 25～50 parts of Fructus Aristolochiae Kwangsiensiss of 25～55 portions of Rhizoma Polygonati Odorati of Radix Aeschynomenes indicae
10～45 parts of 15～45 portions of Bulbus Lycoridis Radiataes of 15～45 parts of Fructus Akebiaes of 20～45 parts of Herba Micromeriae Bifloraes of Herba leerisae hexandrae
6～30 parts of 8～35 parts of Rhizoma Acori Calami of 8～40 parts of Radix Perillae of 10～40 parts of Radixs Angelicae Dahuricae of Semen Ziziphi Spinosae.
2. a kind of Chinese medicine preparation for the treatment of Menieres disease according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
34～51 parts of 35～55 parts of Semen Cassiaes of 35～55 portions of Fructus Evodiaes of 45～65 parts of Radix Polygalaes of Periostracum Cicadae
24～41 parts, 25～45 parts of Fructus Amomi Rotunduss of 29～46 parts of Fructus Aristolochiae Kwangsiensiss of 30～50 portions of Rhizoma Polygonati Odorati of Radix Aeschynomenes indicae
16～39 parts of 20～40 portions of Bulbus Lycoridis Radiataes of 20～40 parts of Fructus Akebiaes of 24～41 parts of Herba Micromeriae Bifloraes of Herba leerisae hexandrae
10～26 parts of 12～31 parts of Rhizoma Acori Calami of 13～35 parts of Radix Perillae of 15～35 parts of Radixs Angelicae Dahuricae of Semen Ziziphi Spinosae.
3. a kind of Chinese medicine preparation for the treatment of Menieres disease according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
39～47 parts of 40～50 parts of Semen Cassiaes of 40～50 portions of Fructus Evodiaes of 50～60 parts of Radix Polygalaes of Periostracum Cicadae
28～37 parts, 30～40 parts of Fructus Amomi Rotunduss of 33～42 parts of Fructus Aristolochiae Kwangsiensiss of 35～45 portions of Rhizoma Polygonati Odorati of Radix Aeschynomenes indicae
22～33 parts of 25～35 portions of Bulbus Lycoridis Radiataes of 25～35 parts of Fructus Akebiaes of 28～37 parts of Herba Micromeriae Bifloraes of Herba leerisae hexandrae
14～22 parts of 16～27 parts of Rhizoma Acori Calami of 18～30 parts of Radix Perillae of 20～30 parts of Radixs Angelicae Dahuricae of Semen Ziziphi Spinosae.
4. a kind of Chinese medicine preparation for the treatment of Menieres disease according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
43 parts of 45 parts of Semen Cassiaes of 45 portions of Fructus Evodiaes of 55 parts of Radix Polygalaes of Periostracum Cicadae
33 parts, 35 parts of Fructus Amomi Rotunduss of 38 parts of Fructus Aristolochiae Kwangsiensiss of 40 portions of Rhizoma Polygonati Odorati of Radix Aeschynomenes indicae
28 parts of 30 portions of Bulbus Lycoridis Radiataes of 30 parts of Fructus Akebiaes of 33 parts of Herba Micromeriae Bifloraes of Herba leerisae hexandrae
18 parts of 21 parts of Rhizoma Acori Calami of 24 parts of Radix Perillae of 25 parts of Radixs Angelicae Dahuricae of Semen Ziziphi Spinosae.
5. a preparation method for the treatment of the Chinese medicine preparation of Menieres disease as described in claim 1～4 any one, is characterized in that: comprise following processing step:
(1) by Periostracum Cicadae, Semen Cassiae, Fructus Aristolochiae Kwangsiensis, Semen Ziziphi Spinosae and the Radix Angelicae Dahuricae with mix, after mix homogeneously, carry out pulverization process, grind into powder, cross 160 order fine powders, for subsequent use;
(2) Radix Polygalae, Radix Aeschynomenes indicae, Herba leerisae hexandrae, Herba Micromeriae Biflorae, Radix Perillae and Rhizoma Acori Calami are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 ℃, relative density is 1.12～1.17, for subsequent use;
(3) Fructus Evodiae and Bulbus Lycoridis Radiatae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) Rhizoma Polygonati Odorati, Fructus Amomi Rotundus and Fructus Akebiae are cleaned, immersed 70% the alcohol solution dipping 1～2 hour of 3 times of amounts, heating extraction 3 hours, reclaims ethanol, filter, and the thick paste that at 60 ℃ of simmer down tos, relative density is 1.11～1.15, for subsequent use;
(5) above-mentioned steps (1)～(4) prepared fine powder, thick paste and juice are mixed, make tablet or capsule, obtain the Chinese medicine preparation for the treatment of Menieres disease of the present invention.
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