CN106075106A - A kind of Chinese medicine composition treating hypertension and preparation method thereof - Google Patents

Abstract

The invention belongs to technical field of Chinese medicines, a kind of Chinese medicine composition treating hypertension and preparation method thereof, compositions is made up of the raw material of following weight portion: 26 parts of Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 10 14 parts, Herb Gynostemmae Pentaphylli 37 parts, the Radix Paeoniae Alba 28 parts, Fructus Crataegi 10 14 parts, Radix Salviae Miltiorrhizae 5 12 parts, Herba Violae 8 12 parts, Herba Taxilli 5 11 parts, Juncus effcus 26 parts, the Cortex Eucommiae 8 12 parts, Rhizoma Chuanxiong 4 12 parts, Spica Prunellae 10 20 parts, Rhizoma Coptidis 5 10 parts, store 39 parts, Fructus Tribuli 10 15 parts, 16 parts of Radix Glycyrrhizae.This Chinese medicine composition treats hypertension by blood fat reducing, blood circulation promoting and blood stasis dispelling, nourishing yin and purging fire, the principle of enhancing blood vessel elasticity, there is the advantage strengthening body immunity, alleviating hypertension complication generation, and preparation method is simple, understandable, total effective rate reaches 93.8% by clinic application, without obvious toxic-side effects, great generalization.

Description

A kind of Chinese medicine composition treating hypertension and preparation method thereof

[technical field]

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition treating hypertension and preparation method thereof.

[background technology]

Hypertension is the disease of lasting hyperpiesia, can cause the diseases such as apoplexy, heart disease, hemangioma, renal failure, hypertension It is that a kind of rising with arterial pressure is characterized, can complete with the functional or organic change of heart, blood vessel, brain and kidney and other organs Body disease, it have essential hypertension and secondary hypertension point.The reason of hypertension incidence is a lot, can be divided into heredity and Two aspects of environment.The symptoms such as the clinical manifestation of primary disease, has weak, thirsty, polyuria.Vision goes down rapidly, and there is retina on optical fundus Hemorrhage and ooze out, often there is bilateral papilloedema.Albuminuria, hematuria and renal insufficiency occur rapidly.The heart also can occur Force failure, hypertensive encephalopathy and hypertensive crisis, course advancement rapidly more dies from uremia.Pathologic is: the most without disease Shape, finds that blood pressure increases once in a while during health check-up, or at psychentonia, feel after excited or fatigue dizziness, headache, dim eyesight, tinnitus, Insomnia, the symptom such as weak, absent minded, may be caused by higher mental functional disorder, and blood pressure the most temporarily raises in early days, with Course advancement blood pressure persistently raises, and internal organs are got involved；Brain shows as headache, dizzy common, how due to excited, the most tired Labor, climate change or disable depressor and induce, the hurried rising of blood pressure, severe headache, visual disorder, Nausea and vomiting, tic, Stupor, transient hemiplegia, aphasia etc.；Cardiac Manifestation, in early days, cardiac functional compensation, symptom is inconspicuous, the later stage, and cardiac function loses compensatory, There is heart failure；Kidney shows as long-term hypertension and causes renal arteriolosclerosis.During renal hypofunction, nocturia can be caused, polyuria, Containing albumen, cast and erythrocyte in urine.Urine concentrating power is low, phenol red excretion and urea clearance obstacle.Occur azotemia and Uremia.High blood pressure disease is treated, it is possible to reduce the complication such as cardiovascular and cerebrovascular vessel to greatest extent by the means of Chinese medicine Incidence rate and mortality rate, treatment aspect has the effect that it is original.

[summary of the invention]

It is an object of the invention to: for the problem of above-mentioned existence, it is provided that a kind of Chinese medicine composition treating hypertension and system thereof Preparation Method, treats hypertension by blood fat reducing, blood circulation promoting and blood stasis dispelling, nourishing yin and purging fire, the principle of enhancing blood vessel elasticity, has enhancing flesh Body immunity, the advantage alleviating hypertension complication generation.

According to the theory of the traditional Chinese medical science, the clinical manifestation of different pattern of syndrome hypertension is: headache, dizziness, the hurried rising of blood pressure, vision barrier Hinder, Nausea and vomiting, twitch, go into a coma, renal hypofunction causes nocturia, containing albumen, cast and erythrocyte, heart failure in polyuria, urine Exhaust.Hypertension can be divided into constitutional and the big class of Secondary cases two.Essential hypertension in most patients, the disease of hypertension Because of not clear, referred to as essential hypertension, account for more than the 95% of total hypertension.Secondary hypertension is secondary to other diseases, the most often As be by kidney and adrenal gland diseases caused by, and endocrine hypertension.Essential hypertension, in being more common in, old, its Feature be onset concealment, make slow progress, the course of disease up to more than 10 year to many decades, therefore initial stage little symptom, about half patient because of Health check-up or because measuring after blood pressure when other diseases is sought medical advice, just chances on blood pressure and increases, and many patients once know suffer from high blood After pressure, various neurosis sample symptom can be produced on the contrary, such as dizziness, feeling of fullness in the head, insomnia, forgetful, tinnitus, weak, dreaminess, easily Exciting etc..The clinical manifestation of secondary hypertension: albuminuria/hematuria occurs early, degree weight, Impaired kidney function are obvious, night Urine increases, lower limb are weak or periodic paralysis, the hypokalemia that causes with persistence or diuretic, have gout, anaphylactoid purpura, Polycythemia vera, hematoporphyrinism acute attack, lead poisoning acute stage, hypercalcemia, mountain hypoxia state etc..

The Chinese medicine composition prescription of the present invention is developed, the skill used according to the mechanism of above-mentioned essential hypertension disease Art scheme is as follows:

The present invention treats the Chinese medicine composition of hypertension, is made up of the raw material of following weight portion: Rhizoma Gastrodiae 2-6 part, Ramulus Uncariae Cum Uncis 10-14 Part, Herb Gynostemmae Pentaphylli 3-7 part, Radix Paeoniae Alba 2-8 part, Fructus Crataegi 10-14 part, Radix Salviae Miltiorrhizae 5-12 part, Herba Violae 8-12 part, Herba Taxilli 5-11 part, Juncus effcus 2-6 part, Cortex Eucommiae 8-12 part, Rhizoma Chuanxiong 4-12 part, Spica Prunellae 10-20 part, Rhizoma Coptidis 5-10 part, store 3-9 part, Fructus Tribuli 10-15 part, sweet Grass 1-6 part.

Preferably, the Chinese medicine composition of above-mentioned treatment hypertension is made up of the raw material of following weight portion: Rhizoma Gastrodiae 3-5 part, Ramulus Uncariae Cum Uncis 11-13 part, Herb Gynostemmae Pentaphylli 4-6 part, Radix Paeoniae Alba 4-6 part, Fructus Crataegi 11-13 part, Radix Salviae Miltiorrhizae 7-9 part, Herba Violae 9-11 part, Herba Taxilli 6-10 Part, Juncus effcus 3-5 part, Cortex Eucommiae 9-11 part, Rhizoma Chuanxiong 6-10 part, Spica Prunellae 14-16 part, Rhizoma Coptidis 6-9 part, storage 5-7 part, Fructus Tribuli 11- 13 parts, Radix Glycyrrhizae 2-5 part.

It is highly preferred that the Chinese medicine composition of above-mentioned treatment hypertension is made up of the raw material of following weight portion: 4 parts of Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 12 parts, Herb Gynostemmae Pentaphylli 5 parts, the Radix Paeoniae Alba 5 parts, Fructus Crataegi 12 parts, Radix Salviae Miltiorrhizae 8 parts, Herba Violae 10 parts, Herba Taxilli 8 parts, Juncus effcus 4 parts, the Cortex Eucommiae 10 Part, Rhizoma Chuanxiong 8 parts, Spica Prunellae 15 parts, Rhizoma Coptidis 8 parts, storage 6 parts, Fructus Tribuli 12 parts, 4 parts of Radix Glycyrrhizae.

The preparation method of the Chinese medicine composition of above-mentioned treatment hypertension, comprises the following steps:

(1) by Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Herb Gynostemmae Pentaphylli, the Radix Paeoniae Alba, Fructus Crataegi, Radix Salviae Miltiorrhizae, Herba Violae, Herba Taxilli, Juncus effcus, the Cortex Eucommiae, Rhizoma Chuanxiong, Spica Prunellae, Huang Company, storage, Fructus Tribuli, Radix Glycyrrhizae add pulverizes to bavin field formula pulverizer, is crushed to 50-150 mesh, flour extraction control 94～ 98%, obtain medicated powder A；

(2) medicated powder A is inserted in container, add the distilled water of 120-160ml by every 100 grams of medicated powder, after being heated to uniform temperature Held for some time i.e. can be made into medicine slurry B；

(3) medicine is starched B and utilize centrifuge, filter, concentrate the filtrate to 1.05-1.25, obtain water extract, i.e. can be controlled Treat the Chinese medicine composition of hypertension.

In the present invention, further illustrating, in step (1), the granularity of described pulverizing is 50-150 mesh.

In the present invention, further illustrating, in step (2), described temperature is 90-100 DEG C, and the time of insulation is 10- 15 hours.

The Chinese medicine composition of above-mentioned treatment hypertension can make medicament according to conventional pharmaceutical methods, and the dosage form of medicament can Think capsule or oral liquid.

The instructions of taking of this Chinese medicine composition is: each take 50ml, daily three times, and point morning, noon and afternoon take, one The moon is a course for the treatment of, takes 1-3 the course for the treatment of.

The concrete effect of raw material of Chinese medicine employed in the present invention is as follows:

Rhizoma Gastrodiae, Classification system Gastrodia elata Bl. English formal name used at school Tall GasTCMLIBodia Tuber another name is red Arrow, Mokpo, RHIZONA GASTRODIAE, subduing the wind syndrome grass roots etc. are sweet, flat.Return Liver Channel.Endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, removing obstruction in the collateral to relieve pain, there is calmness, town Convulsion, analgesia, convulsion, blood vessel of releiving etc. act on.

Ramulus Uncariae Cum Uncis, Ramulus Uncariae Cum Uncis has another name called Ramulus Uncariae cum Uncis, hangs rattan, rattan hook, fishhook rattan, Oriolus chinensis diffusus pawl wind, tender hook hook, gold Ramulus Uncariae Cum Uncis, hook rattan, hook Fourth, Ramulus Uncariae Cum Uncis, lifting lug.Main component: containing an ancient unit of weight rattan alkali, isorhynchophylline, corynoxeine, different corynoxeine, corynantheine alkali, Dihydrocorynantheine alkali, hirsutine, hirsuteine.Different Ramulus Uncariae Cum Uncis, corynoxein, different corynoxein, hair cap spar Alkali, dehydrogenation hair 9-methoxycorynantheidine., pocket HUAMU alkali and dihydro pocket HUAMU alkali.Sweet, be slightly cold, return liver, pericardium channel.Endogenous wind stopping relieving convulsion, heat clearing away is put down Liver, there is blood vessel of releiving, blood pressure lowering, convulsion, the effect such as calm.

Herb Gynostemmae Pentaphylli, Latin literary fame: Gynostemma pentaphyllum (Thunb.) Makino, also known as paradise grass, good fortune Sound grass, Chao Rencan, Herb Gynostemmae Pentaphylli, Herba Gynostemmatis, Herba Gynostemmatis, Pentapanax and gynostemma pentaphyllum makino etc., Cucurbitaceae, Gynostemma herbaceous stem are climbed up by holding on to Plant；Stem is thin and delicate, has branch, the vertical rib of tool and groove, sweet in the mouth, hardship, cold nature.Return lung meridian, spleen channel, kidney channel..Energy QI invigorating, calms the nerves, fall Blood pressure, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.

The Radix Paeoniae Alba, formal name used at school: Paeonia lactiflora Pall, Classification system Cynanchum otophyllum, also referred to as Paeonia sterniana Fletcher in Journ., Radix Cynanchi Otophylli is Ranunculaceae Paeonia plant.At the existing long cultivation history of China, having won fame both at home and abroad, it claims to spend in vain Radix Paeoniae.Its root can be used as medicine.Perennial herb or undershrub, be born in hillside, the bushes in mountain valley or thick grass.China is mostly Qu Junyou plants, bitter, sour, is slightly cold.Return Liver Channel, spleen channel.Nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing receives antiperspirant.Enriching blood yin fluid astringing, easing the affected liver is only Bitterly, suppressing the hyperactive liver and subsiding YANG, having nourish blood buffering vascular pressure effect.

Fructus Crataegi, Classification system: Crataegus pinnatifida Bunge, have another name called fruit, Fructus Pyri Pashiae, Rosaceae mountain in mountain Short, bristly hair or beard belongs to, deciduous tree, high up to 6 meters.In Shandong, Shaanxi, Shanxi, Henan, Jiangsu, Zhejiang, Liaoning, Jilin, Heilungkiang, Inner Mongol All there is distribution on the ground such as Gu, Hebei.Stone fruit, caryoplasm is hard, and sarcocarp is thin, and taste is micro-sour and astringent.The most raw-eaten or make preserved fruit fruitcake, dry Can be used as medicine after system, be Chinese distinctive medicine fruit dual-purpose seeds, bitter in the mouth, it is slightly cold, nontoxic.Enter the heart, Liver Channel.For obstruction of qi in the chest and cardialgia, gastral cavity Abdomen hypochondriac pain, the accumulation of abdominal mass abdominal mass, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, skin infection swells and ache.Have blood fat reducing, blood pressure, Heart tonifying, arrhythmia etc. act on, and are also the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting simultaneously, hernia full to chest and diaphragm spleen The diseases such as gas, blood stasis, amenorrhea have good curative effect.Flavone compound vitexin in Fructus Crataegi, is that a kind of antitumaous effect is stronger Medicine, the internal growth of cancer cells of suppression, propagation and infiltration metastasis are all had certain effect by its extract.

Herba Violae, Classification system: Corydalis bungeana Turcz, another name: Herba corydalis edulis, Peng Shi Herba corydalis edulis, Bu Shi Herba Violae etc.. For perennial herb, high 10-30 centimetre.Root is thin and straight, few branch, fallow.Stem is thin and delicate, from base portion to surrounding multi-branched, There are rib, celadon, light hair or thin growth pubescence.Basal leaf is grown thickly, basal leaf alternate, has handle；Adaptability is relatively strong, likes warm the coolest Cool and refreshing air time.Cold-resistant, be afraid of drought.Requiring soil not tight, clay, loam, sand loam all can be planted.Distribution Guangdong, Guangxi, Zhejiang The ground such as river, Jiangxi, with dry herb hyoscine.Toil, cold, nontoxic.Enter liver, spleen two warp.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Control temperature Sick high heat is irritated, influenza, infectious hepatitis, nephritis, scrofula, parotitis, furuncle and other pyogenic infection.

Herba Taxilli, Classification system: Taxillus sutchuenensis (Lecomte) Danser, another name peach tree is parasitic, Ramulus et Folium Loranthi Chinensis etc..Twig, Ye Mi, by brown or bronzing stellate hair, have a scattered candelabra hair sometimes, sprig black, without hair, Has scattered hole skin.Originate in the ground such as Yunnan, Sichuan, Gansu, Shaanxi, Shanxi, Henan, Guizhou, Hubei, Hunan.Bitter；Sweet；Property flat.Enter The heart, kidney two warp.Invigorating the liver and kidney；Bone and muscle strengthening；Wind-damp dispelling；Antiabortive.Main soreness of waist and knee joint；Muscles and bones flaccidity is weak；Limbs are hemiplegia；Rheumatic arthralgia；Head Wrong dizzy；Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, tire Dynamic uneasiness；Hypertension.

Juncus effcus, formal name used at school: JuncuseffususL, sweet, light, be slightly cold, GUIXIN, lung, small intestine meridian.Inducing diuresis for treating stranguria syndrome, the relieving restlessness that clears away heart-fire, Have and dispel dysphoria with smothery sensation, purification blood effect.

The Cortex Eucommiae, formal name used at school: Eucommia ulmoides Oliver, Classification system Eucommia ulmoides has another name called glue Wood, for Eucommiaceae plant, Cortex Eucommiae free amino acid is few, a small amount of protein contained, be with most foodstuffs as complete Whole protein, i.e. can hydrolyze the detection 8 kinds of aminoacid to needed by human.Determine 15 kinds of mineral elements contained by the Cortex Eucommiae, wherein There are the macroelements such as the trace element such as zinc, copper, ferrum, and calcium, phosphorus, potassium, magnesium.Sweet, temperature.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, peace Tire.Controlling spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination itches, and vaginal bleeding during pregnancy is intended to fall, frequent fetal movement, hypertension.

Rhizoma Chuanxiong, Classification system: Ligusticum chuanxiong Hort, cultivated plant, main product in Sichuan, in Yunnan, The ground such as Guizhou, Guangxi, is grown on the climatic environment of gentleness.It is a kind of Chinese medicinal plant, acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Live Blood gas, wind-expelling pain-stopping.For pacifying nerve, positive wind syndrome of head is had a headache, and lump in the abdomen is suffered from abdominal pain, breast side of body twinge, tumbling and swelling, headache, rheumatism Arthralgia pain.

Spica Prunellae, Classification system: Prunella vulgaris L, another name: wheat head Spica Prunellae, iron wire Spica Prunellae, Mai Xia Withered, the iron wire summer is withered, sunset sentence, Nedong etc.；For herbaceos perennial, creeping rootstock, raw fibrous root on joint.Stem is up to 30 centimetres, base Portion's multi-branched, lilac.Calyx is bell, and filigree is the most flat, and style is very thin, and tip sliver bores shape, excurvation.The nearly flat-top of floral disc.Little Nut yellowish-brown, the month at florescence 4-6, really the phase 7-10 month.Spica Prunellae be grown in the wet thick grass of gully meadow bog or both sides, riverbank, wasteland, Roadside, is distributed widely in all over China, and with Henan, Anhui, Jiangsu, Hunan etc. save as the main place of production.Bitter, acrid, cold.Enter liver, gallbladder Warp.There are the effect of improving eyesight of relieving inflammation or internal heat, clearing away liver-fire, blood pressure lowering, mass dissipating and swelling eliminating.Control hypertension, hyperlipidemia, high blood viscosity, hyperglycemia, scrofula Scrofula, goiter, acute mastitis swell and ache.

Rhizoma Coptidis, Classification system: Coptis chinensis Franch. calls: taste company, Rhizoma Coptidis, Rhizoma Coptidis, belong to Ranunculaceae, Huang Even belonging to herbaceos perennial, phyllopodium is hesitated, hard papery, ovum shape triangle, and three totally cleave, central authorities' sliver ovum shape rhombus, pinniform drastic crack, There is sharp sawtooth at edge, and the raw sliver in side does not wait 2 drastic cracks；The long 5-12cm of petiole.Wild or cultivate in the mountain valley of height above sea level 1000-1900m In cool wet concealment thick forest.(root) is bitter, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For Damp and hot feeling of fullness, vomits acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, and heat in blood is told nosebleed, conjunctival congestion, toothache, disappeared Yearningly, carbuncle furuncle；External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice is clear Harmonization of the stomach stomach preventing or arresting vomiting.Tying mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomit Tell acid regurgitation.

Storing, Classification system: Polygonum aviculare L, Herba Polygoni Avicularis is annual herb plant, has another name called flat bamboo, many By raw road outside of the city, early summer opens pale red or white little Hua in internode, autumn has set in knot, and tender leaf can be used as medicine.It is distributed in all over China. Hardship, cold.Enter bladder warp.Diuresis, heat clearing away, parasite killing.Controlling pyretic stranguria, the difficulty in urination, jaundice, the erosion of the vulva, leucorrhea, ascarid, infantile malnutrition, hemorrhoid swell, eczema.

Fructus Tribuli, Classification system Tribulus terrester L, have another name called Fructus Atriplicis Sibiricae, bend people etc..Stem is flat sleeping, without hair, is grown Pubescence or long bristle.There is distribution all parts of the country.Be born in sand ground, wasteland, hillside, the ground such as near residential area.Green grass or young crops can be cooked feedstuff time fresh. Fruit be used as medicine can suppressing the hyperactive liver improving eyesight, dissipate be in fashion blood.Fruit thorn easily adheres between domestic animal hair, damages coat quality.For grassland noxious plant.Pungent, Hardship, tepor；Slightly poisonous.Return Liver Channel.Suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic.For dizziness of having a headache, distending pain in the chest and hypochondrium, breast closes Acute mastitis, cataract, rubella pruritus.

Radix Glycyrrhizae, Classification system Glycyrrhiza uralensis Fisch, another name: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., Sweet root.Pulse family, Glycyrrhiza perennial herb, root is sturdy with root stock, is a kind of tonification Chinese herbal medicine.One good to human body Medicine, medicinal part is root and rhizome, and Medicinal Materials Characters root is cylinder, long 25～100 centimetres, diameter 0.6～3.5 centimetres.Crust Degree of tightness differs, surface red brown or taupe brown.Rhizome is cylinder, and there is bud trace on surface, has marrow in the middle part of section.Feeble QI, taste sweet and Special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc..Happiness is dark moist, sunshine the low dry climate of long temperature.Radix Glycyrrhizae It is grown in desert steppe arid, semiarid, desert edge and loess hill area more.Root and root stock hyoscine.It is sweet, flat, Return lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, have buffering blood flow effect.

In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows:

The prescription of the present invention, scientific and reasonable compatibility, is to develop, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, the Radix Paeoniae Alba, mountain for treatment essential hypertension Short, bristly hair or beard is releived blood vessel, except cold in blood vessel, purifies the effect of vascular environment；Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Coptidis, Herba Violae have the relieving restlessness that clears away heart-fire, peace Comfort nerve, heat-clearing and toxic substances removing, effect of dispersing cold for relieving pain；Juncus effcus, storage have inducing diuresis for treating stranguria syndrome, purify the function of blood；The Cortex Eucommiae, Herba Taxilli Raw have invigorating the liver and kidney, effect of nourishing YIN and moistening the lung；Spica Prunellae, Fructus Tribuli can clearing away heat to improve acuity of vision, blood pressure lowering, liver heat removing effect of fire；Radix Glycyrrhizae, Herb Gynostemmae Pentaphylli has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, effect of buffering blood flow.All medicines share, and play blood fat reducing, blood circulation promoting and blood stasis dispelling, YIN nourishing altogether Pathogenic fire purging, effect of enhancing blood vessel elasticity, have the advantage strengthening body immunity, alleviating hypertension complication generation.Through clinic Application achieves obvious clinical effectiveness, is used for treating essential hypertension, and total effective rate reaches 93.8%, makees without substantially poison is secondary With.

[detailed description of the invention]

The invention provides a kind of Chinese medicine composition treating hypertension, be made up of the raw material of following weight portion: Rhizoma Gastrodiae 2-6 part, Ramulus Uncariae Cum Uncis 10-14 part, Herb Gynostemmae Pentaphylli 3-7 part, Radix Paeoniae Alba 2-8 part, Fructus Crataegi 10-14 part, Radix Salviae Miltiorrhizae 5-12 part, Herba Violae 8-12 part, Herba Taxilli 5- 11 parts, Juncus effcus 2-6 part, Cortex Eucommiae 8-12 part, Rhizoma Chuanxiong 4-12 part, Spica Prunellae 10-20 part, Rhizoma Coptidis 5-10 part, store 3-9 part, Fructus Tribuli 10-15 part, Radix Glycyrrhizae 1-6 part.Kinds of traditional Chinese medicines complements each other, and plays blood fat reducing, blood circulation promoting and blood stasis dispelling, nourishing yin and purging fire, enhancing blood vessel elasticity altogether Merit, and then strengthen body immunity, alleviate hypertension complication and occur, the effective state of an illness controlling essential hypertension.With Under by specific embodiment, the invention will be further described.

Embodiment 1

The present invention treats the Chinese medicine composition of hypertension, is made up of the raw material of following weight portion: Rhizoma Gastrodiae 2g, Ramulus Uncariae Cum Uncis 10g, strand Blue 3g, Radix Paeoniae Alba 2g, Fructus Crataegi 10g, Radix Salviae Miltiorrhizae 5g, Herba Violae 8g, Herba Taxilli 5g, Juncus effcus 2g, Cortex Eucommiae 8g, Rhizoma Chuanxiong 4g, Spica Prunellae 10g, Huang Even 5g, storage 3g, Fructus Tribuli 10g, Radix Glycyrrhizae 1g.

Following method is used to prepare this Chinese medicine composition:

(1) by Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Herb Gynostemmae Pentaphylli, the Radix Paeoniae Alba, Fructus Crataegi, Radix Salviae Miltiorrhizae, Herba Violae, Herba Taxilli, Juncus effcus, the Cortex Eucommiae, Rhizoma Chuanxiong, Spica Prunellae, Huang Company, storage, Fructus Tribuli, Radix Glycyrrhizae addition are pulverized to bavin field formula pulverizer, are crushed to 100 mesh, and flour extraction controls, 96%, to obtain Medicated powder A；

(2) medicated powder A is inserted in container, add the distilled water of 140ml by every 100 grams of medicated powder, be heated to temperature 95 DEG C, be incubated 12 Individual hour, make medicine slurry B；

(3) medicine being starched B and utilize centrifuge, filter, concentrate the filtrate to 1.15, obtain water extract, can obtain medical treatment height The Chinese medicine composition of blood pressure.

Embodiment 2

The present invention treats the Chinese medicine composition of hypertension, is made up of the raw material of following weight portion: Rhizoma Gastrodiae 3g, Ramulus Uncariae Cum Uncis 11g, strand Blue 4g, Radix Paeoniae Alba 4g, Fructus Crataegi 11g, Radix Salviae Miltiorrhizae 7g, Herba Violae 9g, Herba Taxilli 6g, Juncus effcus 3g, Cortex Eucommiae 9g, Rhizoma Chuanxiong 6g, Spica Prunellae 14g, Huang Even 6g, storage 5g, Fructus Tribuli 11g, Radix Glycyrrhizae 2g.

Following method is used to prepare this Chinese medicine composition:

(1) by Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Herb Gynostemmae Pentaphylli, the Radix Paeoniae Alba, Fructus Crataegi, Radix Salviae Miltiorrhizae, Herba Violae, Herba Taxilli, Juncus effcus, the Cortex Eucommiae, Rhizoma Chuanxiong, Spica Prunellae, Huang Company, storage, Fructus Tribuli, Radix Glycyrrhizae addition are pulverized to bavin field formula pulverizer, are crushed to 150 mesh, and flour extraction controls, 98%, to obtain Medicated powder A；

(2) medicated powder A is inserted in container, add the distilled water of 160ml by every 100 grams of medicated powder, be heated to temperature 100 DEG C, insulation 15 hours, make medicine slurry B；

(3) medicine being starched B and utilize centrifuge, filter, concentrate the filtrate to 1.25, obtain water extract, can obtain medical treatment height The Chinese medicine composition of blood pressure.

Embodiment 3

The present invention treats the Chinese medicine composition of hypertension, is made up of the raw material of following weight portion: Rhizoma Gastrodiae 4g, Ramulus Uncariae Cum Uncis 12g, strand Blue 5g, Radix Paeoniae Alba 5g, Fructus Crataegi 12g, Radix Salviae Miltiorrhizae 8g, Herba Violae 10g, Herba Taxilli 8g, Juncus effcus 4g, Cortex Eucommiae 10g, Rhizoma Chuanxiong 8g, Spica Prunellae 15g, Rhizoma Coptidis 8g, storage 6g, Fructus Tribuli 12g, Radix Glycyrrhizae 4g.

Following method is used to prepare this Chinese medicine composition:

(1) by Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Herb Gynostemmae Pentaphylli, the Radix Paeoniae Alba, Fructus Crataegi, Radix Salviae Miltiorrhizae, Herba Violae, Herba Taxilli, Juncus effcus, the Cortex Eucommiae, Rhizoma Chuanxiong, Spica Prunellae, Huang Company, storage, Fructus Tribuli, Radix Glycyrrhizae addition are pulverized to bavin field formula pulverizer, are crushed to 50 mesh, and flour extraction controls, 94%, to obtain medicine Powder A；

(2) medicated powder A is inserted in container, add the distilled water of 120ml by every 100 grams of medicated powder, be heated to temperature 90 DEG C, be incubated 10 Individual hour, make medicine slurry B；

(3) medicine being starched B and utilize centrifuge, filter, concentrate the filtrate to 1.05, obtain water extract, can obtain medical treatment height The Chinese medicine composition of blood pressure.

Embodiment 4

The present invention treats the Chinese medicine composition of hypertension, is made up of the raw material of following weight portion: Rhizoma Gastrodiae 6g, Ramulus Uncariae Cum Uncis 14g, strand Blue 7g, Radix Paeoniae Alba 8g, Fructus Crataegi 14g, Radix Salviae Miltiorrhizae 12g, Herba Violae 12g, Herba Taxilli 11g, Juncus effcus 6g, Cortex Eucommiae 12g, Rhizoma Chuanxiong 12g, Spica Prunellae 20g, Rhizoma Coptidis 10g, storage 9g, Fructus Tribuli 15g, Radix Glycyrrhizae 6g.

The method identical with embodiment 3 is used to prepare this Chinese medicine composition.

Embodiment 5

The present invention treats the Chinese medicine composition of hypertension, is made up of the raw material of following weight portion: Rhizoma Gastrodiae 5g, Ramulus Uncariae Cum Uncis 13g, strand Blue 6g, Radix Paeoniae Alba 6g, Fructus Crataegi 13g, Radix Salviae Miltiorrhizae 9g, Herba Violae 11g, Herba Taxilli 10g, Juncus effcus 5g, Cortex Eucommiae 11g, Rhizoma Chuanxiong 10g, Spica Prunellae 16g, Rhizoma Coptidis 9g, storage 7g, Fructus Tribuli 13g, Radix Glycyrrhizae 5g.

The method identical with embodiment 3 is used to prepare this Chinese medicine composition.

In order to observe the clinical efficacy of present composition treatment hypertension, the present invention is carried out Preliminary Clinical Observation, Now clinical test results is reported as follows:

(1) object of observation: during in June, 2015-December, uses the Chinese medicine composition of the present invention to treat 80 example patients altogether, man 49 examples, in age 45-80 year, average 62.5 years old, the course of disease was the shortest 1 month, the longest 5 years；Female 31 example, age 43-78 year, average 60.5 In year, the course of disease is the shortest 1 month, the longest 3 years.

(2) diagnostic criteria: dizziness, cardiopalmus, uncomfortable in chest, myasthenia of limbs, white and thin fur, dizzy, irritated, bitter taste, insomnia, red tongue, Slight Hypertension, the bodily form are fat.

(3) Therapeutic Method: arbitrary Chinese medicine composition made in oral embodiment of the present invention 1-5, each takes 50ml, often Day takes three times, and point morning, noon and afternoon take, and within one month, are a course for the treatment of, take 1-3 the course for the treatment of, follow up a case by regular visits to after 3 months, statistics recurrence feelings Condition.

(4) the standard of curative effect evaluation:

Cure: sign and symptom are improved completely, happy, in high spirits.

Effective: sign and symptom significantly improve, happy, spirit is very well.

Effective: sign and symptom change, random thoughts are slightly uncomfortable, but can accept.

Invalid: sign is without changing, and symptom is the most front.

(5) therapeutic outcome: in 80 example cases, through 1-3 course of therapy, wherein cures 43 examples, effective 17 examples, and effective 15 Example, invalid 5 examples, total effective rate 93.8%, the course for the treatment of is the shortest 30 days, the longest 150 days, follows up a case by regular visits to 1 year have no recurrence.

Model case:

Lee 62 years old, man, suffers from hypertension 5 years as long as, controls weary effect, dizziness, cardiopalmus, uncomfortable in chest, myasthenia of limbs, white and thin fur, blood pressure repeatly (170/105 millimetres of mercury) is taken the Chinese medicine composition of embodiment 1 and is taken effect January, 3 the course for the treatment of state of an illness controlled.

Zhang, 56 years old, man, hypertension incidence 1 year, because thing is not achieved one's goal, blood pressure rises to (175/105 millimetres of mercury), Over the past half year, dizzy, dizzy, irritated, bitter taste, insomnia, red tongue, tongue are micro-white the most yellow, and the Chinese medicine composition taking embodiment 1 is shown in January Effect, cures 3 courses for the treatment of.

Hu, 64 years old, female, blood pressure detecting numerical value was 150/100, dizziness, cardiopalmus, uncomfortable in chest, myasthenia of limbs, white and thin fur, mesh Dizzy, irritated, the bodily form is fat, the Chinese medicine composition taking embodiment 1 takes effect January, and 3 courses for the treatment of cure.

Described above is the detailed description for the preferable possible embodiments of the present invention, but embodiment is not limited to this Bright patent claim, the equal change completed under the technical spirit suggested by all present invention or modification change, all should belong to In the contained the scope of the claims of the present invention.

Claims (6)

1. the Chinese medicine composition treating hypertension, it is characterised in that: it is made up of the raw material of following weight portion: Rhizoma Gastrodiae 2-6 part, Ramulus Uncariae Cum Uncis 10-14 part, Herb Gynostemmae Pentaphylli 3-7 part, Radix Paeoniae Alba 2-8 part, Fructus Crataegi 10-14 part, Radix Salviae Miltiorrhizae 5-12 part, Herba Violae 8-12 part, Herba Taxilli 5- 11 parts, Juncus effcus 2-6 part, Cortex Eucommiae 8-12 part, Rhizoma Chuanxiong 4-12 part, Spica Prunellae 10-20 part, Rhizoma Coptidis 5-10 part, store 3-9 part, Fructus Tribuli 10-15 part, Radix Glycyrrhizae 1-6 part.

The Chinese medicine composition for the treatment of hypertension the most according to claim 1, it is characterised in that: by the raw material of following weight portion Make: Rhizoma Gastrodiae 3-5 part, Ramulus Uncariae Cum Uncis 11-13 part, Herb Gynostemmae Pentaphylli 4-6 part, Radix Paeoniae Alba 4-6 part, Fructus Crataegi 11-13 part, Radix Salviae Miltiorrhizae 7-9 part, Herba Violae 9- 11 parts, Herba Taxilli 6-10 part, Juncus effcus 3-5 part, Cortex Eucommiae 9-11 part, Rhizoma Chuanxiong 6-10 part, Spica Prunellae 14-16 part, Rhizoma Coptidis 6-9 part, Store 5-7 part, Fructus Tribuli 11-13 part, Radix Glycyrrhizae 2-5 part.

The Chinese medicine composition for the treatment of hypertension the most according to claim 1, it is characterised in that: by the raw material of following weight portion Make: 4 parts of Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 12 parts, Herb Gynostemmae Pentaphylli 5 parts, the Radix Paeoniae Alba 5 parts, Fructus Crataegi 12 parts, Radix Salviae Miltiorrhizae 8 parts, Herba Violae 10 parts, Herba Taxilli 8 parts, Juncus effcus 4 parts, the Cortex Eucommiae 10 parts, Rhizoma Chuanxiong 8 parts, Spica Prunellae 15 parts, Rhizoma Coptidis 8 parts, storage 6 parts, Fructus Tribuli 12 parts, 4 parts of Radix Glycyrrhizae.

4. according to the preparation method of the Chinese medicine composition of the treatment hypertension described in claim 1,2 or 3, it is characterised in that: bag Include following steps:

(1) by Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Herb Gynostemmae Pentaphylli, the Radix Paeoniae Alba, Fructus Crataegi, Radix Salviae Miltiorrhizae, Herba Violae, Herba Taxilli, Juncus effcus, the Cortex Eucommiae, Rhizoma Chuanxiong, Spica Prunellae, Huang Company, storage, Fructus Tribuli, Radix Glycyrrhizae addition are pulverized to bavin field formula pulverizer, are crushed to 50-150 mesh, and flour extraction controls 94%, To medicated powder A；

(2) medicated powder A is inserted in container, add the distilled water of 120-160ml by every 100 grams of medicated powder, after being heated to uniform temperature Held for some time i.e. can be made into medicine slurry B；

(3) medicine is starched B and utilize centrifuge, filter, concentrate the filtrate to 1.05-1.25, obtain water extract, i.e. can be controlled Treat the Chinese medicine composition of hypertension.

The preparation method of the Chinese medicine composition for the treatment of hypertension the most according to claim 4, it is characterised in that: in step (1), in, the granularity of described pulverizing is 50-150 mesh.

The preparation method of the Chinese medicine composition for the treatment of hypertension the most according to claim 4, it is characterised in that: in step (2) in, described temperature is 90-100 DEG C, and the time of insulation is 10-15 hour.