CN104222632A - Feed for preventing coccidiosis of rabbits - Google Patents
Feed for preventing coccidiosis of rabbits Download PDFInfo
- Publication number
- CN104222632A CN104222632A CN201410459522.8A CN201410459522A CN104222632A CN 104222632 A CN104222632 A CN 104222632A CN 201410459522 A CN201410459522 A CN 201410459522A CN 104222632 A CN104222632 A CN 104222632A
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- feed
- bark
- drug powder
- coccidiosis
- drug
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- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The invention provides a feed for preventing coccidiosis of rabbits. The feed comprises medicinal powder for treating the coccidiosis of the rabbits, corn, rice chaff, bean pulp, wheat bran, fish meal, bone powder and edible salt. The feed can relieve bleeding and diarrhea which are caused by the coccidiosis and achieve the effects of enhancing the organ immunity and the like so as to achieve the effect of treating both symptoms and root causes; the medicament does not have toxic and side effects, can delay the drug resistance, does not have medicament residues and is a good choice for preventing the coccidiosis.
Description
Technical field
The present invention relates to field of feed additive technology, particularly relating to a kind of for preventing the medicine of coccidiosis of rabbit.
Background technology
Coccidiosis of rabbit parasitizes rabbit hepatic duct and enterocyte by the multiple coccidia of Eimeria, and the endobiosis parasitosis caused.Global-worm illness is the most serious a kind of endobiosis parasitosis of harm 30 ~ 70 age in days children rabbit.The coccidium infection rate of children rabbit is 90%, and the death rate is 60%.The sick rabbit initial stage shows as anorexia, and do not like activity, two dull, eye nose punishment secretions, anaemia, diarrhea, becomes thin, and diarrhoea or diarrhoea and constipation sometimes alternately occurs, growth retardation.Time seriously ill, suffer from rabbit and fall down suddenly, muscle cramp, hind leg is tetanic, and forelimb makes imperious paddling, and head is to layback, and utter a heartrending cry sound and dead.The distribution of this disease is wide, propagation is fast, the death rate is high, and all have neurological susceptibility to the rabbit of different cultivars, provisions rabbit industry brings huge economic loss.Resistance to global-worm illness of crossing is dead, or the rabbit through curing becomes long-term carrier, and becomes the infection sources of this disease.
Not yet develop rabbit coccidial vaccine at present, the main method of control coccidiosis of rabbit remains application anticoccidial drug both at home and abroad.Coccidiostat is added in feed, it is the major measure of preventing coccidiosis of rabbit at present, medicine for coccidiosis is a lot, from sulfa drugs the earliest to salinomycin and Maduamicin A plasma carrier class medicine, be complete, but these anticoccidial drugs all also exist defect more or less, some drug toxicities are large, safe range is little, some very easily produces drug resistance, Applicative time too short some can not use with other medicines simultaneously, anticoccidial drugs numerous on market, raiser is often at a loss, blindly application, frequently change dressings, cause global-worm illness obstinate.From the end of the year 2008, now authorize rabbit feed addictive at France, Italy and Spain's diclazuril, but the coccidiostat developed according to Eimeria species pattern, what have is inoperative to rabbit coccidia.Be usually used in preventing the active drug of coccidiosis of rabbit to have Robenidine, diclazuril and salinomycin; Medicine has sulfa drugs and toltrazuril.
Coccidiosis of rabbit belongs to the category of malnutrition due to parasitic infestation Chinese veterinarian, should can reach the effect of preventing and treating global-worm illness with clearing heat and detoxicating, desinsection herbal medicine, meanwhile, be improved the resistance against diseases of ill chicken by the medicine improving immunity of organisms, especially reticuloendothelial function, delays the resistance to the action of a drug and produces.Adopt Chinese herbal medicine prevention coccidiosis of rabbit, the growth suppressing coccidia on the one hand, the resistance function by regulating animal body on the other hand, breed and nonspecific resistance occurs to strengthen body disease-resistant power, arrive and eliminate pathogen and slow down its damage for cell, recover the object of the normal physiological function of body.
Chinese herbal medicine mostly is natural plants, uses herbal control global-worm illness, both can reach the object of preventing and treating global-worm illness, overcomes again frequent application anticoccidial drug and the residue of veterinary drug drawback brought, and not easily produces drug resistance, do not cause environmental pollution.Chinese herbal medicine provided by the invention, by desinsection expelling parasite, bangle removing toxic substances, cooling blood and hemostasis, raising immunity of organisms, can alleviate hemorrhage, the diarrhea because global-worm illness causes, and strengthens the effects such as Abwehrkraft des Koepers again, reaches the effect for the treatment of both principal and secondary aspect of disease.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of for preventing medicine and the feed of coccidiosis of rabbit, employing feed can alleviate hemorrhage, diarrhea because global-worm illness causes, strengthen the effects such as Abwehrkraft des Koepers again, reach the effect for the treatment of both principal and secondary aspect of disease, and this medicine has no side effect, delays drug resistance, drug residue free, be that prevention global-worm illness is well selected.
For solving the problems of the technologies described above, the invention provides a kind of for preventing the feed of coccidiosis of rabbit, it comprises drug powder, corn, rice chaff, dregs of beans, wheat bran, fish meal, bone meal and salt for preventing coccidiosis of rabbit.
Wherein, in described feed, the weight of each raw material is respectively drug powder 0.8kg ~ 1.2kg, corn 45kg ~ 55kg, rice chaff 27kg ~ 33kg, dregs of beans 12kg ~ 18kg, wheat bran 8kg ~ 12kg, fish meal 2kg ~ 4kg, bone meal 1kg ~ 3kg, salt 0.5kg ~ 1.5kg.
Wherein, in described feed, the weight of each raw material is respectively drug powder 1kg, corn 50kg, rice chaff 20kg, dregs of beans 15kg, wheat bran 10kg, fish meal 3kg, bone meal 2kg, salt 1kg.
Wherein, the bulk drug of described drug powder comprises the Chinese bulbul, garden burnet, honeysuckle, Radix Glycyrrhizae, bush, curcuma zedoary, the bark of official magnolia, Centipeda minima, sweet wormwood, asafoetide, Gaultheria, bog starwort herb, Conyza japonica, sargentodoxa cuneata, tuber of stemona, pivot store, the coptis, bark of tree of heaven, garlic, sweetberry jointfir, Spondias axillaris, folium panacis japonici cum caule, nutmeg, notopterygium root, folium isatidis and tabasheer.
Wherein, in described medicine, the weight of each raw material is respectively Chinese bulbul 15g ~ 25g, garden burnet 15g ~ 25g, honeysuckle 35g ~ 45g, Radix Glycyrrhizae 15g ~ 25g, bush 15g ~ 25g, curcuma zedoary 5g ~ 15g, bark of official magnolia 5g ~ 15g, Centipeda minima 5g ~ 15g, sweet wormwood 15g ~ 25g, asafoetide 5g ~ 15g, Gaultheria 15g ~ 25g, bog starwort herb 5g ~ 15g, Conyza japonica 5g ~ 15g, sargentodoxa cuneata 5g ~ 15g, tuber of stemona 15g ~ 25g, pivot stores 15g ~ 25g, coptis 35g ~ 45g, bark of tree of heaven 15g ~ 25g, garlic 15g ~ 25g, sweetberry jointfir 15g ~ 25g, Spondias axillaris 15g ~ 25g, folium panacis japonici cum caule 15g ~ 25g, nutmeg 15g ~ 25g, notopterygium root 5g ~ 15g, folium isatidis 25g ~ 35g and tabasheer 5g ~ 15g.
Wherein, in described medicine, the weight of each raw material is respectively Chinese bulbul 18g ~ 22g, garden burnet 18g ~ 22g, honeysuckle 38g ~ 42g, Radix Glycyrrhizae 18g ~ 22g, bush 18g ~ 22g, curcuma zedoary 8g ~ 12g, bark of official magnolia 8g ~ 12g, Centipeda minima 8g ~ 12g, sweet wormwood 18g ~ 22g, asafoetide 8g ~ 12g, Gaultheria 18g ~ 22g, bog starwort herb 8g ~ 12g, Conyza japonica 8g ~ 12g, sargentodoxa cuneata 8g ~ 12g, tuber of stemona 18g ~ 22g, pivot stores 18g ~ 22g, coptis 38g ~ 42g, bark of tree of heaven 18g ~ 22g, garlic 18g ~ 22g, sweetberry jointfir 18g ~ 22g, Spondias axillaris 18g ~ 22g, folium panacis japonici cum caule 18g ~ 22g, nutmeg 18g ~ 22g, notopterygium root 8g ~ 12g, folium isatidis 28g ~ 32g and tabasheer 8g ~ 12g.
Wherein, in described medicine, the weight of each raw material is respectively Chinese bulbul 20g, garden burnet 20g, honeysuckle 40g, Radix Glycyrrhizae 20g, bush 20g, curcuma zedoary 10g, bark of official magnolia 10g, Centipeda minima 10g, sweet wormwood 20g, asafoetide 10g, Gaultheria 20g, bog starwort herb 10g, Conyza japonica 10g, sargentodoxa cuneata 10g, tuber of stemona 20g, pivot store 20g, coptis 40g, bark of tree of heaven 20g, garlic 20g, sweetberry jointfir 20g, Spondias axillaris 20g, folium panacis japonici cum caule 20g, nutmeg 20g, notopterygium root 10g, folium isatidis 30g and tabasheer 10g.
Present invention also offers the preparation method of said medicine, be specially:
Pulverized respectively by each bulk drug, mix in proportion, mixture loads in percolator, every 500g adds the white wine 800g ~ 1000g of 50 degree ~ 55 degree, soaks 20 hours ~ 30 hours under the condition of 30 DEG C ~ 40 DEG C, regulates percolator valve, white wine liquid is slowly oozed, and the speed of oozing is 2 ~ 4mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain dry drug powder.
Present invention also offers the preparation method of described feed, be specially:
The first step, prepares described drug powder according to method above;
Second step, the drug powder each for all the other in described feed component and the first step prepared is sent in mixer, stirs 30 minutes ~ 1 hour at normal temperatures, obtains feed.
Beneficial effect of the present invention:
The invention provides a kind of for preventing medicine and the feed of coccidiosis of rabbit, adopt this medicine can alleviate hemorrhage, diarrhea because global-worm illness causes, strengthen the effects such as Abwehrkraft des Koepers again, reach the effect for the treatment of both principal and secondary aspect of disease, and this medicine has no side effect, delays drug resistance, drug residue free, be that prevention global-worm illness is well selected.
Detailed description of the invention
The invention provides a kind of for preventing the medicine of coccidiosis of rabbit, its bulk drug comprise the Chinese bulbul, garden burnet, honeysuckle, Radix Glycyrrhizae, bush, curcuma zedoary, the bark of official magnolia, Centipeda minima, sweet wormwood, asafoetide, Gaultheria, bog starwort herb, Conyza japonica, sargentodoxa cuneata, tuber of stemona, pivot store, the coptis, bark of tree of heaven, garlic, sweetberry jointfir, Spondias axillaris, folium panacis japonici cum caule, nutmeg, notopterygium root, folium isatidis and tabasheer.
Further, described medicine is only made up of above-mentioned raw materials medicine.
In described medicine, the weight of each raw material is respectively Chinese bulbul 15g ~ 25g, garden burnet 15g ~ 25g, honeysuckle 35g ~ 45g, Radix Glycyrrhizae 15g ~ 25g, bush 15g ~ 25g, curcuma zedoary 5g ~ 15g, bark of official magnolia 5g ~ 15g, Centipeda minima 5g ~ 15g, sweet wormwood 15g ~ 25g, asafoetide 5g ~ 15g, Gaultheria 15g ~ 25g, bog starwort herb 5g ~ 15g, Conyza japonica 5g ~ 15g, sargentodoxa cuneata 5g ~ 15g, tuber of stemona 15g ~ 25g, pivot stores 15g ~ 25g, coptis 35g ~ 45g, bark of tree of heaven 15g ~ 25g, garlic 15g ~ 25g, sweetberry jointfir 15g ~ 25g, Spondias axillaris 15g ~ 25g, folium panacis japonici cum caule 15g ~ 25g, nutmeg 15g ~ 25g, notopterygium root 5g ~ 15g, folium isatidis 25g ~ 35g and tabasheer 5g ~ 15g.
Further preferably, in described medicine, the weight of each raw material is respectively Chinese bulbul 18g ~ 22g, garden burnet 18g ~ 22g, honeysuckle 38g ~ 42g, Radix Glycyrrhizae 18g ~ 22g, bush 18g ~ 22g, curcuma zedoary 8g ~ 12g, bark of official magnolia 8g ~ 12g, Centipeda minima 8g ~ 12g, sweet wormwood 18g ~ 22g, asafoetide 8g ~ 12g, Gaultheria 18g ~ 22g, bog starwort herb 8g ~ 12g, Conyza japonica 8g ~ 12g, sargentodoxa cuneata 8g ~ 12g, tuber of stemona 18g ~ 22g, pivot stores 18g ~ 22g, coptis 38g ~ 42g, bark of tree of heaven 18g ~ 22g, garlic 18g ~ 22g, sweetberry jointfir 18g ~ 22g, Spondias axillaris 18g ~ 22g, folium panacis japonici cum caule 18g ~ 22g, nutmeg 18g ~ 22g, notopterygium root 8g ~ 12g, folium isatidis 28g ~ 32g and tabasheer 8g ~ 12g.
Most preferably, in described medicine, the weight of each raw material is respectively Chinese bulbul 20g, garden burnet 20g, honeysuckle 40g, Radix Glycyrrhizae 20g, bush 20g, curcuma zedoary 10g, bark of official magnolia 10g, Centipeda minima 10g, sweet wormwood 20g, asafoetide 10g, Gaultheria 20g, bog starwort herb 10g, Conyza japonica 10g, sargentodoxa cuneata 10g, tuber of stemona 20g, pivot store 20g, coptis 40g, bark of tree of heaven 20g, garlic 20g, sweetberry jointfir 20g, Spondias axillaris 20g, folium panacis japonici cum caule 20g, nutmeg 20g, notopterygium root 10g, folium isatidis 30g and tabasheer 10g.
Present invention also offers the preparation method of said medicine, be specially:
Pulverized respectively by each bulk drug, mix in proportion, mixture loads in percolator, every 500g adds the white wine 800g ~ 1000g of 50 degree ~ 55 degree, soaks 20 hours ~ 30 hours under the condition of 30 DEG C ~ 40 DEG C, regulates percolator valve, white wine liquid is slowly oozed, and the speed of oozing is 2 ~ 4mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain dry drug powder.
The present invention also provides a kind of for preventing the feed of coccidiosis of rabbit, and it comprises above-mentioned drug powder, corn, rice chaff, dregs of beans, wheat bran, fish meal, bone meal and salt.
Further, described feed is only made up of above-mentioned raw materials.
In described feed, the weight of each raw material is respectively drug powder 0.8kg ~ 1.2kg, corn 45kg ~ 55kg, rice chaff 27kg ~ 33kg, dregs of beans 12kg ~ 18kg, wheat bran 8kg ~ 12kg, fish meal 2kg ~ 4kg, bone meal 1kg ~ 3kg, salt 0.5kg ~ 1.5kg.
In described feed, the weight of each raw material is respectively drug powder 1kg, corn 50kg, rice chaff 20kg, dregs of beans 15kg, wheat bran 10kg, fish meal 3kg, bone meal 2kg, salt 1kg.
Present invention also offers the preparation method of described feed, be specially:
The first step, prepares described drug powder according to method above;
Second step, the drug powder each for all the other in described feed component and the first step prepared is sent in mixer, stirs 30 minutes ~ 1 hour at normal temperatures, obtains feed.
Each bulk drug pharmacology is as follows:
The Chinese bulbul: bitter, cold in nature, enter stomach, large intestine channel, there is effect that is clearing heat and detoxicating, that remove heat from the blood and relieve diarrhea, the treatment of the symptoms such as being mainly used in stomach has damp and hot stagnant heating to suffer from abdominal pain, diarrhea purulence blood, tenesmus, better to blood effect under the hot dysentery of large intestine blood-head, the Chinese bulbul all has certain inhibitory action to shigella dysenteriae, typhoid bacillus, hay bacillus, Escherichia coli, Gold production staphylococcus.
Garden burnet: bitter, acid, cold in nature, return liver; Lung; Kidney; Large intestine channel, has cooling blood and hemostasis, clearing heat and detoxicating, and effect of detumescence sore, cures mainly haematemesis, and spitting of blood, bleeding from five sense organs or subcutaneous tissue, hematuria, has blood in stool, hemorrhoid blood, bloody flux, uterine bleeding, leukorrhea with reddish discharge, sore, carbuncle and painful swelling, eczema, pruritus vulvae, scald, the cards such as snake bite and insect sting.
Honeysuckle: latin name lonicerae japonicae flos, have another name called FLOSLONICERAE, honeysuckle flower, honeysuckle, two precious flowers, taste is sweet, cold in nature, enter the heart, lung, stomach, large intestine channel, there is clearing heat and detoxicating effect, doublely to remove heat from the blood and relieve diarrhea, to be mainly used in affection of exogenous wind-heat, the hot poison of warm heat disease is comparatively contained, or when warm disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of heat evil; The malicious diarrhea of heat, the lower blood of stool; Heat temperature is demonstrate,proved; The sore carbuncle that hot poison gathers is from the beginning of the ， inflammation heat person of swelling and ache, and other skin infections, and this thing has good antipyretic effect, has antiinflammatory action, can promote leukocytic phagocytic function, have stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria.
Radix Glycyrrhizae: taste is sweet, property put down, enter 12 warps, have clearing heat and detoxicating, be in harmonious proportion the property of medicine, the effect of expelling phlegm and arresting coughing, and can invigorating the spleen and in, relieving spasm to stop pain, is mainly used in weakness of the spleen and the stomach abdominal distension and anorexia, weak; Contraction pain in abdomen being alleviated, relax the strong and toxicity of some drugs, alleviate medicine to the toxic and side effect of body or to GI stimulation, tonifying Qi neutralization can be played by adding Radix Glycyrrhizae, be in harmonious proportion the effect of each component.
Bush: latin name sappan lignum, taste is sweet, one-tenth, and property is put down, and enters the heart, liver, large intestine channel, has promoting blood circulation, effect of swelling and pain relieving, for blood stasis amenorrhoea, dysmenorrhoea, the stagnant stomachache of the stasis of blood in postpartum, traumatic injury, fracture, the cards such as carbuncle sore tumefacting virus, have obvious inhibitory action to various tumor cell strains.
Curcuma zedoary: taste is pungent, bitter, warm in nature, enters liver, the spleen channel, has broken blood gas, the effect of the long-pending pain relieving that disappears, and for the abdominal mass lump in the abdomen of caused by energy stagnation and blood stasis, chest abdomen stasis of blood pain, amenorrhoea, dysmenorrhoea, abdominal distention, traumatic injury, blood stasis such as to swell and ache at the card.
The bark of official magnolia: bitter, pungent, warm in nature, returns the spleen channel; Stomach warp; Large intestine channel, has promoting the circulation of qi and disappears long-pending; Eliminating dampness is except full; Effect of relieving asthma, cures mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Damp retention in middle-jiao, gastral cavity ruffian is vomited and diarrhoea;
Phlegm stops up the circulation of vital energy in the wrong direction; Fullness sensation in chest such as to be breathed with cough at the card.
Centipeda minima: taste is pungent, warm in nature, enter lung, Liver Channel, there is cold-dispelling, clearing the nasal passage, cough-relieving apophlegmatic, the effect of eliminating stasis to subdue swelling, for exterior syndrome due to wind-cold, nasal obstruction runny nose and nasosinusitis, coughing with a lot of sputum, pertussis, the cards such as sore, carbuncle and painful swelling.
Sweet wormwood: latin name Artemisiae Annuae Herba, bitter, pungent, cold in nature, return liver, gallbladder channel, have abnormal heat clearly thoroughly, cool blood is except steaming, and except steaming, effect of preventing malaria, cures mainly summer-heat evil heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to yin labor heat, malaria fever and chills, the cards such as jaundice with damp-heat pathogen.
Asafoetide: bitter, pungent, warm in nature, returns kidney, stomach warp, has to disappear long-pending, and loose ruffian, effect of desinsection, stagnates for meat, hemostasis abdominal mass, mass in abdomen, the cards such as abdominal pain due to enterositosis.
Gaultheria: be root or the cauline leaf of the white strain tree of Ericaceae Gaultheria plant, taste is pungent, puckery, warm in nature, and gas fragrance, has the effect of dispelling rheumatism, cure mainly rheumatic arthritis, the cards such as traumatic injury.
Bog starwort herb: be the herb of Caryophyllaceae Stellaria plant tongue of sparrow grass, taste is pungent, property is put down, and returns lung, the spleen channel, has and dispel rheumatism, activating blood circulation and reducing swelling, and effect of removing toxic substances hemostasis, cures mainly flu, rushes down dysentery, arthralgia due to wind-dampness, traumatic injury, venomous snake bite, spits blood, the cards such as traumatism and bleeding.
Conyza japonica: bitter, pungent, cold in nature, have clearing away heat to and alleviating pain, effect of dispelling pathogenic wind and eliminating phlegm, cures mainly laryngitis, pneumonia, abscess of throat, the cards such as tonsillitis.
Sargentodoxa cuneata: bitter, property is put down, and return liver, large intestine channel, have the carbuncle that disappears that relieves internal heat, promoting blood circulation and removing obstruction in channels, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, arthralgia due to wind-dampness, dysentery characterized by blood in the stool, and blood drenches, irregular menstruation, infantile malnutrition due to digestive disturbances or intestinalparasites, worm pain, the cards such as injury from falling down.
The tuber of stemona: taste is sweet, bitter, slightly warm in nature enters lung channel, have and moisten the lung and relieve the cough, the effect of delousing desinsection, tuber of stemona temperature embellishes but not dry, and property is kept and do not walk, there is out again the merit of drop-down gas, be mainly used in newly all for a long time coughing, be especially suitable for the hot chronic cough person of labor, the modern times are used for the cough preventing and treating chronic bronchitis, the dry cough of pulmonary tuberculosis, the cards such as pertussis.
Pivot stores: latin name Polygoni Avicularis Herba, bitter, and cold nature, enters urinary bladder channel, has promoting diuresis for stranguria, effect of killing parasites to relieve itshing, for stranguria, especially sand drenches, urolithiasis, difficult urination, jaundice with damp-heat pathogen, rushes down dysentery, is with inferior Zheng ， pivot to store and has significant diuresis.
The coptis: bitter, cold in nature, enter the heart, lung, courage, stomach, large intestine channel, have heat-clearing and damp-drying drug, purging intense heat and detonicating, the effect of cooling blood for improving eyesight, be usually used in the fire for the treatment of removing the heart-fire warp, the dysphoria and insomnia that internal heat is prosperous, and the high fever coma of warm heat disease, the symptom such as vexed, thirsty.
Bark of tree of heaven: bitter, puckery, cold in nature, enters large intestine, stomach, Liver Channel, has heat-clearing and damp-drying drug, and puckery intestines are band only, hemostasis, and the effect of desinsection, for damp-heat dysentery, rushes down protracted dysentery for a long time, uterine bleeding, have blood in stool, blood under hemorrhoid, under band, and the cards such as hematochezia.
Garlic: warm in nature, taste is pungent flat; Enter spleen, stomach, lung channel, have in temperature help digestion, the stagnant gas of row, warming spleen and stomach, long-pending, the removing toxic substances of disappearing, desinsection effect, cure mainly eating accumulation, coldness and pain in the epigastrium, oedema turgor, have loose bowels, dysentery, malaria, pertussis, swollen ulcer drug, white bald tinea sore, snake bite and insect sting and the illness such as hookworm, pinworm.
Sweetberry jointfir: bitter, slightly warm in nature, has and dispels rheumatism, blood stasis removing analgesic, and effect of preventing phlegm from forming and stopping coughing, cures mainly arthralgia due to wind-dampness, pain in the back, treating swelling and pain by traumatic injury, the fracture injury of tendon and muscle, ulcer haemorrhage, chronic bronchitis, the cards such as venomous snake bite.
Spondias axillaris: taste is sweet, sour, property is put down, and has the promoting flow of qi and blood circulation, mental-tranquilization, and the effect of the long-pending removing toxic substances that disappears, cures mainly qi depression to blood stasis, pectoralgia, palpitation, neurasthenia, insomnia, bronchitis, eat stagnant abdomen full, the cards such as diarrhoea.
Folium panacis japonici cum caule: bitter, sweet, cold in nature, attach to the lung and stomach meridians, have tonifying Qi, beneficial lung, drives away summer heat, and the effect of promoting the production of body fluid, cures mainly qi-asthenia cough, and hot summer weather is irritated, and Tianjin wound is thirsty, and the head is unclear, and four limbs are tired wearyly waits card.
Nutmeg: latin name Myristicae Semen, taste is pungent, bitter, warm in nature, enters spleen, stomach, large intestine channel, cards such as having the effect of puckery intestines, promote qi circulation digestion promoting in temperature, rush down for void, cold dysentery, abdominal distention, food are vomitted less, place food does not disappear.
Notopterygium root: latin name Notopterygii Rhizoma et Radix, taste is pungent, bitter, warm in nature, enter kidney, urinary bladder channel, there is effect of loose cold, the expelling wind and eliminating dampness of inducing sweat, pain relieving, there is the wet illness that has not attacked the vital organs of the human body of chill folder, disease sees that fever with aversion to cold, headache are as wrapped up in, neck rigid back pain, and limbs are heavy, the cards such as joint is ached, wind-cold-dampness arthralgia.
Folium isatidis: latin name Isatidis Folium, bitter, property Great Cold, the thoughts of returning home, liver, courage, stomach warp, have antipyretic and detoxicated, cooling blood and dissolving purpura, effect of removing jaundice, can clearly gas divide reality heat, can separate again the heat poison of blood system, be mainly used in the high hot sweating that seasonal febrile diseases pyreticosis is caused, polydipsia draws drink; The spot that fire poison is flourishing is gone mad, the symptoms such as haematemesis; The unconsciousness due to high fever of measles, rash look purple is dark; Liver and gallbladder damp-heat accumulates the jaundice of steaming; The deafness and tinnitus of liver and gall fire liter; The card such as pharyngalgia, aphthae, hepatitis that the hot and suffocating poison of fire is caused.
Tabasheer: lightly seasoned, property is put down, and have preventing phlegm from forming and stopping coughing, promoting blood circulation to remove blood stasis, the effect of dispelling rheumatism, cures mainly cough ant phlegm, pertussis, under band, stomachache, arthralgia due to wind-dampness, child convulsion, the cards such as traumatic injury.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 drug powder 1
By Chinese bulbul 20g, garden burnet 20g, honeysuckle 40g, Radix Glycyrrhizae 20g, bush 20g, curcuma zedoary 10g, bark of official magnolia 10g, Centipeda minima 10g, sweet wormwood 20g, asafoetide 10g, Gaultheria 20g, bog starwort herb 10g, Conyza japonica 10g, sargentodoxa cuneata 10g, tuber of stemona 20g, pivot stores 20g, coptis 40g, bark of tree of heaven 20g, garlic 20g, sweetberry jointfir 20g, Spondias axillaris 20g, folium panacis japonici cum caule 20g, nutmeg 20g, notopterygium root 10g, folium isatidis 30g and tabasheer 10g pulverizes respectively, mix in proportion, mixture loads in percolator, every 500g adds the white wine 1000g of 50 degree, soak 30 hours under the condition of 30 DEG C, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 3mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain dry drug powder 1.
Embodiment 2 drug powder 2
By Chinese bulbul 18g, garden burnet 18g, honeysuckle 38g, Radix Glycyrrhizae 18g, bush 18g, curcuma zedoary 8g, bark of official magnolia 8g, Centipeda minima 8g, sweet wormwood 18g, asafoetide 8g, Gaultheria 18g, bog starwort herb 8g, Conyza japonica 8g, sargentodoxa cuneata 8g, tuber of stemona 18g, pivot stores 18g, coptis 38g, bark of tree of heaven 18g, garlic 18g, sweetberry jointfir 18g, Spondias axillaris 18g, folium panacis japonici cum caule 18g, nutmeg 18g, notopterygium root 8g, folium isatidis 28g and tabasheer 8g pulverizes respectively, mix in proportion, mixture loads in percolator, every 500g adds the white wine 1000g of 50 degree, soak 30 hours under the condition of 30 DEG C, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 3mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain dry drug powder 2.
Embodiment 3 drug powder 3
By Chinese bulbul 22g, garden burnet 22g, honeysuckle 42g, Radix Glycyrrhizae 22g, bush 22g, curcuma zedoary 12g, bark of official magnolia 12g, Centipeda minima 12g, sweet wormwood 22g, asafoetide 12g, Gaultheria 22g, bog starwort herb 12g, Conyza japonica 12g, sargentodoxa cuneata 12g, tuber of stemona 22g, pivot stores 22g, coptis 42g, bark of tree of heaven 22g, garlic 22g, sweetberry jointfir 22g, Spondias axillaris 22g, folium panacis japonici cum caule 22g, nutmeg 22g, notopterygium root 12g, folium isatidis 32g and tabasheer 12g pulverizes respectively, mix in proportion, mixture loads in percolator, every 500g adds the white wine 1000g of 50 degree, soak 30 hours under the condition of 30 DEG C, regulate percolator valve, white wine liquid is slowly oozed, the speed of oozing is 3mL per minute, to the color oozed is transparent, collect the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain dry drug powder 3.
Embodiment 4 toxicity test
Embodiment 4 pharmacological toxicity is tested
Acute toxicity test data
Detect reagent
Serum AST, ALT detection kit are purchased from Rui Sheng bio tech ltd, Qingdao
Checkout equipment
Micro-200 semiautomatic biochemistry detector, assay balance, disscting instrument, syringe, test tube etc.
Test method
After the adaptability of 3 days are raised, be divided at random 4 groups (male and female half and half), often organize each 20; Control group, 3 different pharmaceutical groups (are respectively 200g/kg body weight, 160g/kg body weight, 120g/kg body weight), control group gavage physiological saline, the drug powder 1 of 3 the medicine group gavage embodiment of the present invention 1 preparations, is dissolved in Chinese herbal feed additive in water and gavages mouse.
Testing index and method
(1) clinicing symptom observation: every day viewing test mouse the state of mind, diet situation, every day entry morbidity death condition.
(2) pathological observation: dead mouse is carried out cuing open inspection and observes internal organ change.
(3) growth indexes is observed: carry out routine weighing to test mouse; Off-test, slaughters that mouse weighs in, the heavy organ index of internal organs measures: cut open inspection rat, core dirty, spleen, liver, kidney, testis, ovary, weigh, calculate organ index according to the following formula: organ index=internal organs weight/body weight × 100.
(4) liver function change is observed: after off-test, slaughter mouse, take blood separation of serum, measures AST, ALT.
Data processing: above data acquisition SPSS 11.0 carries out analytic statistics.
Clinicing symptom observation
Control group and test group mouse, the state of mind and diet wish, to external world respond have no obvious exception.Each group of mouse morbidity and death condition are as following table 1.
Table 1
| Grouping | Sum | Dead (only) | The death rate (%) |
| 1(200g/kg) | 20 | 0 | 0 |
| 2(160g/kg) | 20 | 0 | 0 |
| 3(120g/kg) | 20 | 0 | 0 |
| Control group | 20 | 0 | 0 |
Pathological observation: control group and test group, mouse carries out cuing open inspection and observes to have no and observe the obvious pathological change of internal organs after slaughtering.
Growth indexes is observed: off-test, slaughters that mouse weighs in, internal organs weight analysis is in table 2.
Table 2
| Grouping | Liver index | Cardiac index | Renal index | Lungs index | Index and spleen index |
| 1(200g/kg) | 5.58±0.12 | 0.74±0.02 | 1.30±0.19 | 0.68±0.05 | 0.52±0.01 |
| 2(160g/kg) | 5.49±0.19 | 0.73±0.05 | 1.21±0.13 | 0.67±0.03 | 0.50±0.03 |
| 3(120g/kg) | 5.62±0.12 | 0.73±0.09 | 1.31±0.12 | 0.71±0.05 | 0.52±0.03 |
| Control group | 5.86±0.21 | 0.71±0.02 | 1.33±0.11 | 0.70±0.07 | 0.50±0.02 |
Liver function change is observed
After off-test, slaughter mouse, take blood separation of serum, measure AST (glutamic-oxalacetic transaminease), ALT (glutamic-pyruvic transaminase) in table 3.It is not remarkable that result shows each group of data difference compared with normal healthy controls group, is all in normal range (NR).
Table 3
| Grouping | Sum | ALT | AST |
| 1(200g/kg) | 20 | 36.10±2.21 | 128.29±11.13 |
| 2(160g/kg) | 20 | 36.17±2.12 | 130.16±12.32 |
| 3(120g/kg) | 20 | 36.22±2.39 | 131.29±16.21 |
| Control group | 20 | 37.31±4.12 | 130.62±13.27 |
Long term toxicity test data
Chinese herbal feed additive 10g/kg, 20g/kg, 100g/kg of the present invention of preparing according to embodiment 1 were to the continuous gastric infusion of rat 3 months, the fur of animal, the colour of skin, ingest, activity, the blood parameters such as routine blood test, Liver and kidney function of the animal all without exception such as urine, feces and animal main organs index all in normal range (NR), and normal kinetic indifference histopathologic examination shows, the important organs such as the heart, liver, spleen, lung, kidney, adrenal gland, tracheae, testis, ovary are without pathological change.Drug withdrawal checks above indices all without overt toxicity reaction after two weeks, show without cumulative toxicity.
Embodiment 5 feed 1
The drug powder 1 1kg embodiment 1 prepared, corn 50kg, rice chaff 20kg, dregs of beans 15kg, wheat bran 10kg, fish meal 3kg, bone meal 2kg, salt 1kg send in mixer, stir 1 hour at normal temperatures, obtain feed 1.
Comparative example 1 feed 2
Corn 50kg, rice chaff 20kg, dregs of beans 15kg, wheat bran 10kg, fish meal 3kg, bone meal 2kg, salt 1kg, 50g diclazuril are sent in mixer, stirs 1 hour at normal temperatures, obtain feed 2.
Comparative example 2 feed 3
Corn 50kg, rice chaff 20kg, dregs of beans 15kg, wheat bran 10kg, fish meal 3kg, bone meal 2kg, salt 1kg are sent in mixer, stirs 1 hour at normal temperatures, obtain feed 3.
Embodiment 6 prophylactic tria
Experimental design and grouping
Experimental rabbits is divided into 4 groups at random, often organizes 30, the raising of 2, every cage, and number.First group is blank group, feed 3 prepared by feeding comparative example 2, second group to the 4th group is infect mixing coccidian oocyst respectively, feed 1 prepared by second group of feeding embodiment 5, feed 2 prepared by the 3rd group of feeding comparative example 1, feed 3 prepared by the 4th group of feeding comparative example 2, test period is 28 days.
Egg capsule is inoculated
Feed after pastille feed 3d, infected group rabbit every oral vaccination 1 × 10
5individual mixing coccidian oocyst.
Test index
Clinical health and analyse observation
The state of mind of observational record every day experimental rabbit, appetite, ight soil situation and feed consumption rate.Dead if any rabbit in test, then anatomic observation pathological change in time, slaughters rabbit and observes pathology after off-test.
Weigh
Test the 0th, 7,14,21 and 28 days respectively by only weighing.
Feed conversion rate
Computing formula is: feed conversion rate=day feed consumption/Average weight increasing a day
Coccidian oocyst discharges statistics
Collect every rabbit ight soil test the 0th, 7,14,21 and 28 days, calculate the worm's ovum number (e.p.g) in its every gram ight soil by Mai Kemasiteshi method (McMaster ' s method).When egg capsule density is too large, count after stepwise dilution.
Effect of drugs judges
By clinical observation and analyse observation, with egg sac number, daily gain for index, medicine group and control group are carried out t inspection, and judges effect of drugs.
4th group started to occur 4 phenomenons of having loose bowels on 7th, 6 occur that appetite declines, feed intake reduces, and within 13rd, occurs dead 3, gets ight soil and gall-bladder plate coating checking, visible many coccidian oocysts, 14th to the 28th, occur that group is searched for food decline, spirit was depressed, phenomenon of having loose bowels all is had to occur, to off-test dead 16 altogether.Second group of whole process only has 1 rabbit to have loose bowels, and do not occur death, microscopy does not find encephalitozoon cuniculi, and the 3rd group occurs 5 phenomenons of having loose bowels, and do not occur death, microscopy does not find encephalitozoon cuniculi, and total result is in table 1.
Table 1 is fallen ill death condition
| Group | Test number | The incidence of disease | The death rate |
| First group | 30 | 0 | 0 |
| Second group | 30 | 0 | 0 |
| 3rd group | 30 | 16.7％(5/30) | 0 |
| 4th group | 30 | 100％(30/30) | 53.3％(16/30) |
Anticoccidial effect, the results are shown in Table 2.
Table 2 coccidian oocyst discharges situation of change (egg sac number e.p.g × 10
5/ g ight soil)
| Group | 0 day | 7 days | 14 days | 21 days | 28 days |
| First group | Do not detect | Do not detect | Do not detect | Do not detect | Do not detect |
| Second group | Do not detect | 1.39±0.11 | Do not detect | Do not detect | Do not detect |
| 3rd group | Do not detect | 3.92±0.17 | 1.76±0.13 | 0.05±0.01 | Do not detect |
| 4th group | Do not detect | 17.39±1.59 | 59.26±2.10 | 37.93±1.03 | 29.61±2.72 |
Duration of test, carry out 5 ight soil Coccidians, the worm egg sac number result of table 2 shows, adopts drug powder provided by the invention, worm egg sac number is similar to blank group, what change does not occur, and prevention effect clearly, adopts diclazuril group when the 7th day detects, worm egg sac number comparatively blank group significantly increases, sharply decline subsequently, inhibition is fine, does not use the infected group worm's ovum capsule digital display work of any medicine to rise.
Daily gain situation, the results are shown in Table 3.
Table 3 daily gain situation compares g
| Group | An average starting weight | Average end is heavy | Average day increment |
| First group | 993.19±46.17 | 1347.31±79.83 | 12.6±3.1 |
| Second group | 971.60±57.56 | 1898.71±63.51 | 33.1±4.3 |
| 3rd group | 986.35±20.17 | 1763.31±52.39 | 27.7±6.3 |
| 4th group | 996.19±39.53 | 1356.29±57.29 | 12.9±2.5 |
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. for preventing a feed for coccidiosis of rabbit, it is characterized in that: comprise the drug powder for preventing coccidiosis of rabbit, corn, rice chaff, dregs of beans, wheat bran, fish meal, bone meal and salt.
2. feed as claimed in claim 1, is characterized in that: the weight of each raw material is respectively drug powder 0.8kg ~ 1.2kg, corn 45kg ~ 55kg, rice chaff 27kg ~ 33kg, dregs of beans 12kg ~ 18kg, wheat bran 8kg ~ 12kg, fish meal 2kg ~ 4kg, bone meal 1kg ~ 3kg, salt 0.5kg ~ 1.5kg.
3. feed as claimed in claim 1 or 2, is characterized in that: the weight of each raw material is respectively drug powder 1kg, corn 50kg, rice chaff 20kg, dregs of beans 15kg, wheat bran 10kg, fish meal 3kg, bone meal 2kg, salt 1kg.
4. the feed as described in claims 1 to 3, is characterized in that: the bulk drug of described drug powder comprises the Chinese bulbul, garden burnet, honeysuckle, Radix Glycyrrhizae, bush, curcuma zedoary, the bark of official magnolia, Centipeda minima, sweet wormwood, asafoetide, Gaultheria, bog starwort herb, Conyza japonica, sargentodoxa cuneata, tuber of stemona, pivot store, the coptis, bark of tree of heaven, garlic, sweetberry jointfir, Spondias axillaris, folium panacis japonici cum caule, nutmeg, notopterygium root, folium isatidis and tabasheer.
5. the feed as described in Claims 1-4, it is characterized in that: in described drug powder, the weight of each raw material is respectively Chinese bulbul 15g ~ 25g, garden burnet 15g ~ 25g, honeysuckle 35g ~ 45g, Radix Glycyrrhizae 15g ~ 25g, bush 15g ~ 25g, curcuma zedoary 5g ~ 15g, bark of official magnolia 5g ~ 15g, Centipeda minima 5g ~ 15g, sweet wormwood 15g ~ 25g, asafoetide 5g ~ 15g, Gaultheria 15g ~ 25g, bog starwort herb 5g ~ 15g, Conyza japonica 5g ~ 15g, sargentodoxa cuneata 5g ~ 15g, tuber of stemona 15g ~ 25g, pivot stores 15g ~ 25g, coptis 35g ~ 45g, bark of tree of heaven 15g ~ 25g, garlic 15g ~ 25g, sweetberry jointfir 15g ~ 25g, Spondias axillaris 15g ~ 25g, folium panacis japonici cum caule 15g ~ 25g, nutmeg 15g ~ 25g, notopterygium root 5g ~ 15g, folium isatidis 25g ~ 35g and tabasheer 5g ~ 15g.
6. the feed as described in claim 1 to 5, it is characterized in that: in described drug powder, the weight of each raw material is respectively Chinese bulbul 18g ~ 22g, garden burnet 18g ~ 22g, honeysuckle 38g ~ 42g, Radix Glycyrrhizae 18g ~ 22g, bush 18g ~ 22g, curcuma zedoary 8g ~ 12g, bark of official magnolia 8g ~ 12g, Centipeda minima 8g ~ 12g, sweet wormwood 18g ~ 22g, asafoetide 8g ~ 12g, Gaultheria 18g ~ 22g, bog starwort herb 8g ~ 12g, Conyza japonica 8g ~ 12g, sargentodoxa cuneata 8g ~ 12g, tuber of stemona 18g ~ 22g, pivot stores 18g ~ 22g, coptis 38g ~ 42g, bark of tree of heaven 18g ~ 22g, garlic 18g ~ 22g, sweetberry jointfir 18g ~ 22g, Spondias axillaris 18g ~ 22g, folium panacis japonici cum caule 18g ~ 22g, nutmeg 18g ~ 22g, notopterygium root 8g ~ 12g, folium isatidis 28g ~ 32g and tabasheer 8g ~ 12g.
7. the feed as described in claim 1 to 6, is characterized in that: in described drug powder, the weight of each raw material is respectively Chinese bulbul 20g, garden burnet 20g, honeysuckle 40g, Radix Glycyrrhizae 20g, bush 20g, curcuma zedoary 10g, bark of official magnolia 10g, Centipeda minima 10g, sweet wormwood 20g, asafoetide 10g, Gaultheria 20g, bog starwort herb 10g, Conyza japonica 10g, sargentodoxa cuneata 10g, tuber of stemona 20g, pivot store 20g, coptis 40g, bark of tree of heaven 20g, garlic 20g, sweetberry jointfir 20g, Spondias axillaris 20g, folium panacis japonici cum caule 20g, nutmeg 20g, notopterygium root 10g, folium isatidis 30g and tabasheer 10g.
8. the preparation method of feed described in claim 1 to 7, is characterized in that, comprising:
The first step, pulverizes each bulk drug in described drug powder respectively, mixes in proportion, mixture loads in percolator, and every 500g adds the white wine 800g ~ 1000g of 50 degree ~ 55 degree, soaks 20 hours ~ 30 hours under the condition of 30 DEG C ~ 40 DEG C, regulate percolator valve, white wine liquid is slowly oozed, and the speed of oozing is 2 ~ 4mL per minute, to the color oozed is transparent, collects the drip oozed, obtain percolate, concentrated, removing white wine, dry, pulverize, obtain dry drug powder;
Second step, the drug powder each for all the other in described feed component and the first step prepared is sent in mixer, stirs 30 minutes ~ 1 hour at normal temperatures, obtains feed.
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| CN104222631A (en) * | 2014-09-10 | 2014-12-24 | 青岛华仁技术孵化器有限公司 | Feed for treating coccidiosis of rabbits |
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