CN103494927A - Traditional Chinese medicine composition for treating chicken respiratory disease and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chicken respiratory disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating a chicken respiratory disease. The traditional Chinese medicine composition is prepared from the following raw herbal materials in parts by weight: 5-15 parts of scutellaria baicalensis, 3-18 parts of ephedra, 3-10 parts of perilla nankinensis, 4-17 parts of houttuynia cordata, 2-10 parts of cortex phellodendri, 3-14 parts of fructus forsythiae, 2-14 parts of dandelion, 2-17 parts of cyrtomium fortunei, 3-22 parts of radix isatidis, 3-18 parts of folium isatidis and 4-16 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention has the following beneficial effects: the traditional Chinese medicine composition can be used for preventing and treating the infectious chicken respiratory disease, enhancing the disease resistance of chicken, and improving the survival rate of the chicken, and is low in price and worthy of promotion and application.
Description
Technical field
The present invention relates to contain the veterinary who derives from plant, animal or mineral component and use preparation, particularly a kind of Chinese medicine composition that is used for the treatment of respiratory disease of chicken and preparation method thereof.
Background technology
The bacterial respiratory tract disease of the kind of respiratory disease of chicken: a..Chronic respiratory tract disease (septic mycoplasma), aspergillosis; B. the respiratory tract disease that virus causes.As newcastle (N D), infectious bronchitis (IB), infectious laryngotracheitis (ILT), influenza (AI); C. the respiratory tract disease that parasite causes.As cryptosporidiosis, leucocyte protozoon disease, endotracheal suction parasitosis.The epidemic characteristic 1. of respiratory disease of chicken is along with the fast development of poultry husbandry, and the kind of chicken respiratory tract disease is more and more.Chicken respiratory tract disease presents old complaint continuation generation at present, the new sick constantly characteristics of appearance, and as newcastle, infectious bronchitis, infectious laryngotracheitis, Frustrate blood and mycoplasma disease, colibacillosis, infective rhinitis etc., chronic illness occurs constantly all the year with popular.Meanwhile, many new sick successively generations, as chicken influenza, Glandular Stomach Type Infections Bronchitis etc.In these emerging epidemic diseases, to pay attention to especially at present the prevention and control of chicken influenza epidemic disease, prevent this disease generation and popular be the task of top priority.2. the case that cause of disease variation, immunosuppressant, atypia disease occur increases.In recent years, each chicken house is all being used various vaccine immunities, but a lot of common vaccines are more and more difficult at some aspect of respiratory disease of prevention and control at present, causes the chicken group after immunity not necessarily all can produce strong protection.When running into when external environment has wild poison to pollute, will make the chicken mass-sending sick.3. the harm of some bacterial disease and parasitic disease is on the rise.Along with increasing and the continuous expansion of scale of feeding chicken in largely scale field, environmental pollution is also more and more serious.Bacterial disease and parasitic disease showed increased, wherein many cause of diseases extensively are present in the poultry environment, can propagate by number of ways, and these pathogenic microorganisms have become the cause of disease of being everlasting in chicken farm.More chief reason is blindly heavy dose of Domain of Abuse Antibiotics of poultry family, makes some common bacterias produce stronger drug resistance, once, after morbidity, many medicines all are difficult to prove effective.4. the case of mixed infection and secondary infection increases.In production practices, along with epidemic disease increases, cultivation density strengthens, add the factors such as environment disinfected is not tight, preventive measure is ineffective, single cause of disease is rare clinically at fowl disease, and a lot of cases are by two or more cause of disease, same chicken body is produced to pathogenic effects, and the case of accompanying infection, secondary infection and mixed infection rises.
The current complexity due to the chicken respiratory disease, therefore specific medicament is not used for treating, and Chinese medicine in line with the principle that consolidates righting the disease for above-mentioned complexity, there is fine therapeutical effect and application prospect, the invention provides a kind of Chinese medicine composition for the treatment of chicken respiratory tract disease, effectively treat the chicken respiratory disease, increased survival rate.
Summary of the invention
The object of the present invention is to provide a kind of instant effect and side effect little be used for the treatment of Chinese medicine composition of respiratory disease of chicken and preparation method thereof.
In order to realize the foregoing invention purpose, the invention provides a kind of Chinese medicine composition that is used for the treatment of respiratory disease of chicken, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Radix Scutellariae 5-15 part, Herba Ephedrae 3-18 part, Folium Perillae 3-10 part, Herba Houttuyniae 4-17 part, Cortex Phellodendri 2-10 part, Fructus Forsythiae 3-14 part, Herba Taraxaci 2-14 part, Rhizoma Osmundae 2-17 part, Radix Isatidis 3-22 part, Folium Isatidis 3-18 part and Radix Glycyrrhizae 4-16 part.
Described Chinese medicine composition also comprises: Semen Lepidii (Semen Descurainiae), Rhizoma Polygoni Cuspidati and Bulbus Fritillariae Cirrhosae; In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Radix Scutellariae 5-15 part, Herba Ephedrae 4-18 part, Folium Perillae 3-10 part, Herba Houttuyniae 5-16 part, Cortex Phellodendri 3-9 part, Fructus Forsythiae 4-12 part, Herba Taraxaci 3-14 part, Rhizoma Osmundae 3-15 part, Radix Isatidis 5-20 part, Folium Isatidis 5-17 part, Radix Glycyrrhizae 5-15 part, Semen Lepidii (Semen Descurainiae) 1-9 part, Rhizoma Polygoni Cuspidati 1-10 part and Bulbus Fritillariae Cirrhosae 2-9 part.
In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is preferably: Radix Scutellariae 8-15 part, Herba Ephedrae 4-12 part, Folium Perillae 5-10 part, Herba Houttuyniae 5-12 part, Cortex Phellodendri 3-6 part, Fructus Forsythiae 4-7 part, Herba Taraxaci 8-14 part, Rhizoma Osmundae 9-15 part, Radix Isatidis 11-20 part, Folium Isatidis 9-17 part, Radix Glycyrrhizae 5-11 part, Semen Lepidii (Semen Descurainiae) 1-5 part, Rhizoma Polygoni Cuspidati 6-10 part and Bulbus Fritillariae Cirrhosae 5-9 part.
In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can also be preferably: Radix Scutellariae 5-11 part, Herba Ephedrae 9-18 part, Folium Perillae 3-8 part, Herba Houttuyniae 8-16 part, Cortex Phellodendri 5-9 part, Fructus Forsythiae 6-12 part, Herba Taraxaci 3-11 part, Rhizoma Osmundae 3-11 part, Radix Isatidis 5-14 part, Folium Isatidis 5-11 part, Radix Glycyrrhizae 8-15 part, Semen Lepidii (Semen Descurainiae) 4-9 part, Rhizoma Polygoni Cuspidati 1-7 part and Bulbus Fritillariae Cirrhosae 2-7 part.
In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can be preferably again: Radix Scutellariae 7-13 part, Herba Ephedrae 6-16 part, Folium Perillae 4-8 part, Herba Houttuyniae 7-13 part, Cortex Phellodendri 3-9 part, Fructus Forsythiae 4-12 part, Herba Taraxaci 3-12 part, Rhizoma Osmundae 3-15 part, Radix Isatidis 5-20 part, Folium Isatidis 5-15 part, Radix Glycyrrhizae 5-15 part, Semen Lepidii (Semen Descurainiae) 3-7 part, Rhizoma Polygoni Cuspidati 3-6 part and Bulbus Fritillariae Cirrhosae 4-7 part.
In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material can also be preferably: 5 parts of 10 parts of Radix Scutellariaes, 12 parts, Herba Ephedrae, 6 parts of Folium Perillaes, 10 parts of Herba Houttuyniae, 6 parts of Cortex Phellodendris, 8 parts of Fructus Forsythiaes, 7 parts of Herba Taraxacis, 9 parts of Rhizoma Osmundae, 12 parts of Radix Isatidis, 10 parts of Folium Isatidiss, 10 parts, Radix Glycyrrhizae, 5 parts of Semen Lepidii (Semen Descurainiae)s, 5 parts of Rhizoma Polygoni Cuspidati and Bulbus Fritillariae Cirrhosaes.
In order better to realize the foregoing invention purpose, the invention provides a kind of preparation method that is used for the treatment of the Chinese medicine composition of respiratory disease of chicken, the dosage form of described Chinese medicine composition is powder, described preparation method comprises the following steps:
(1) take all raw medicinal materials according to ratio of weight and number, after pulverizing, drop into blender and stir 40-60 minute, fully mix to obtain mixture;
(2) add the water with respect to 2～4 times of mixture qualities in mixture, decoct 2～4 hours, filter, add the water with respect to 1～2 times, mixture in filtering residue, again decoct 1～2 hour, filter, twice filtrate is mixed, concentrating under reduced pressure is removed moisture, obtain dry mastic, further and pulverizing dry with spray dryer, sieve and obtain 50～100 order fine powders, obtains powder.
The dosage form of described Chinese medicine composition is decoct, and its preparation method comprises the following steps:
(1) take all raw medicinal materials, pulverize after mix homogeneously, obtain mixture;
(2) add the water with respect to 2～4 times of described mixture qualities in the mixture after pulverizing, decoct 2～4 hours, filter, in filtering residue, add the water with respect to 1～2 times, described mixture again to decoct 1～2 hour, filter, twice filtrate is mixed, and being evaporated to crude drug concentration is 1g/ml～3g/ml.
The present invention also provides a kind of feedstuff, and described feedstuff comprises feed additive and feed vector, and described feed additive comprises that described Chinese medicine composition is as feed additive; With respect to the feed additive of 100 weight portions, the addition of described Chinese medicine additive is the 10-20 weight portion.
The beneficial effect that technical scheme provided by the invention is brought is: Chinese medicine composition of the present invention has the effect of prevention and treatment to avian infectious respiratory tract disease, can strengthen the chicken premunition and improve the chicken survival rate, cheap, have and the advantage such as apply.
The specific embodiment
Embodiment 1 powder
The embodiment of the present invention 1 provides a kind of Chinese medicine composition that is used for the treatment of respiratory disease of chicken, and dosage form is powder, and preparation method comprises the following steps:
(1) take Radix Scutellariae 1000g, Herba Ephedrae 1200g, Folium Perillae 600g, Herba Houttuyniae 1000g, Cortex Phellodendri 600g, Fructus Forsythiae 800g, Herba Taraxaci 700g, Rhizoma Osmundae 900g, Radix Isatidis 1200g, Folium Isatidis 1000g, Radix Glycyrrhizae 1000g, Semen Lepidii (Semen Descurainiae) 500g, Rhizoma Polygoni Cuspidati 500g and Bulbus Fritillariae Cirrhosae 500g, after pulverizing, drop into blender and stir 60 minutes, fully mix to obtain mixture;
(2) add the water with respect to 3 times of mixture qualities in mixture, decoct 3 hours, filter, add the water with respect to 2 times, mixture in filtering residue, again decoct 2 hours, filter, twice filtrate is mixed, concentrating under reduced pressure is removed moisture, obtain dry mastic, further and pulverizing dry with spray dryer, sieve and obtain 80 order fine powders, obtains powder.
Embodiment 2 powder
The embodiment of the present invention 2 provides a kind of Chinese medicine composition that is used for the treatment of respiratory disease of chicken, dosage form is powder, preparation method comprises the following steps: take Radix Scutellariae 1000g, Herba Ephedrae 1100g, Folium Perillae 700g, Herba Houttuyniae 1100g, Cortex Phellodendri 600g, Fructus Forsythiae 600g, Herba Taraxaci 700g, Rhizoma Osmundae 900g, Radix Isatidis 1300g, Folium Isatidis 1100g and Radix Glycyrrhizae 1000g, after pulverizing, drop into blender and stir 55 minutes, fully mix to obtain mixture;
(2) add the water with respect to 4 times of mixture qualities in mixture, decoct 2 hours, filter, add the water with respect to 2 times, mixture in filtering residue, again decoct 2 hours, filter, twice filtrate is mixed, concentrating under reduced pressure is removed moisture, obtain dry mastic, further and pulverizing dry with spray dryer, sieve and obtain 80 order fine powders, obtains powder.
Embodiment 3 decocts
The embodiment of the present invention 3 provides a kind of Chinese medicine composition that is used for the treatment of respiratory disease of chicken, and dosage form is decoct, and its preparation method comprises the following steps:
(1) take Radix Scutellariae 1200g, Herba Ephedrae 800g, Folium Perillae 700g, Herba Houttuyniae 800g, Cortex Phellodendri 500g, Fructus Forsythiae 500g, Herba Taraxaci 1100g, Rhizoma Osmundae 1200g, Radix Isatidis 1600g, Folium Isatidis 1300g, Radix Glycyrrhizae 800g, Semen Lepidii (Semen Descurainiae) 300g, Rhizoma Polygoni Cuspidati 800g and Bulbus Fritillariae Cirrhosae 700g, pulverize after mix homogeneously, obtain mixture;
(2) add the water with respect to 3 times of described mixture qualities in the mixture after pulverizing, decoct 3 hours, filter, add the water with respect to 1 times, described mixture in filtering residue, again decoct 1 hour, filter, twice filtrate is mixed, and being evaporated to crude drug concentration is 2g/ml.
Embodiment 4 feedstuffs
The embodiment of the present invention 4 provides a kind of feedstuff that is used for the treatment of respiratory disease of chicken, the Chinese medicine composition that the feed vector that is 85% by percentage by weight and percentage by weight are 15% forms, and wherein Chinese medicine composition is comprised of the raw medicinal material of following ratio of weight and number: 7 parts of 12 parts of Radix Scutellariaes, 8 parts, Herba Ephedrae, 7 parts of Folium Perillaes, 8 parts of Herba Houttuyniae, 6 parts of Cortex Phellodendris, 6 parts of Fructus Forsythiaes, 11 parts of Herba Taraxacis, 12 parts of Rhizoma Osmundae, 15 parts of Radix Isatidis, 13 parts of Folium Isatidiss, 8 parts, Radix Glycyrrhizae, 3 parts of Semen Lepidii (Semen Descurainiae)s, 8 parts of Rhizoma Polygoni Cuspidati and Bulbus Fritillariae Cirrhosaes.
The preparation method of Chinese medicine composition comprises the following steps:
(1) take Radix Scutellariae 1200g, Herba Ephedrae 800g, Folium Perillae 700g, Herba Houttuyniae 800g, Cortex Phellodendri 600g, Fructus Forsythiae 600g, Herba Taraxaci 1100g, Rhizoma Osmundae 1200g, Radix Isatidis 1500g, Folium Isatidis 1300g, Radix Glycyrrhizae 800g, Semen Lepidii (Semen Descurainiae) 300g, Rhizoma Polygoni Cuspidati 800g and Bulbus Fritillariae Cirrhosae 700g, after pulverizing, drop into blender and stir 55 minutes, fully mix to obtain mixture;
(2) add the water with respect to 4 times of mixture qualities in mixture, decoct 4 hours, filter, add the water with respect to 1 times, mixture in filtering residue, again decoct 1.5 hours, filter, twice filtrate is mixed, concentrating under reduced pressure is removed moisture, obtain dry mastic, further and pulverizing dry with spray dryer, sieve and obtain 50 order fine powders, obtains powder.
Wherein, feed vector is comprised of the raw material of following ratio of weight and number: acorn nut powder 2-7 part, wheat bran 10-20 part, Semen Maydis powder 10-30 part, soybean cake powder 10-20 part, gluten flour 5-15 part, sodium carbonate 1-3 part, sodium bicarbonate 1-3 part, fish flour 5-10 part and rice-chestnut powder 1-5 part.
The preparation method of feedstuff comprises the following steps:
(1) prepare according to the method described above the Chinese medicine composition medicinal powder;
(2) take raw material according to following ratio of weight and number: 3 parts of 4.5 parts, acorn nut powder, 15 parts of wheat brans, 20 parts of Semen Maydis powder, 15 parts of soybean cake powder, 10 parts of gluten flour, 2 parts of sodium carbonate, 2 parts of sodium bicarbonate, 7 parts of fish flour and rice-chestnut powders, gluten flour, sodium carbonate and sodium bicarbonate are added to the water modulation, refining temperature is 55-60 ℃, pour into after stirring in spraying machine and dry, pulverize the acquisition fine powder;
(3) acorn nut powder, wheat bran, Semen Maydis powder, soybean cake powder, fish flour and rice-chestnut powder are mixed to rear the pulverizing, grinding particle size is 350-600mm, makes fine powder amount reach more than 95% of total material, with the fine powder that step (2) obtains, mixs homogeneously, and obtains feed vector;
(4) powder step (1) obtained and step (3) obtain feed vector and mix; putting into multiplex mixer stirs 60 minutes～110 minutes; put into the ring mode bulking machine after taking-up expanded; control the temperature of bulking machine between 80 ℃～95 ℃; the expanded time is 1～2 hour, and the aridity of controlling material to be extruded is 90%～95%, proceeds to after taking-up in ring mode grit machine and is produced into precipitation hard particles feedstuff; then sieve by 10 meshes, obtain described feedstuff.
Wherein, the pharmacology of each raw medicinal material is as follows:
Radix Scutellariae: heat clearing and damp drying is arranged, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.The characteristics that we are strong by broad-spectrum antibacterial action, be used in the fungal culture miscellaneous bacteria and infect special severity, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from pursuing, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: the acute scleritis person, the fire of moxibustion blood trouble also, the removing heat from blood heat extraction, spontaneous recovery also.
Herba Ephedrae: hot, micro-hardship, temperature.Enter lung, urinary bladder channel.Function with cure mainly: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chest breathing with cough, edema due to wind pathogen edema; Bronchial asthma.Honey Herba Ephedrae nourishing the lung to arrest cough.Multiplex in the table disease separate, asthma and cough.Pharmacological research: diaphoresis: 1. effective ingredient volatile oil, ephedrine.2. condition decoction being taken warmly, thermal condition.3. the mechanism of action: hinder sudoriferous duct to the heavily absorption → sweat gland secretion of sodium ion ↑; Excited maincenter, the peripheral alpha receptor.Relieving asthma: 1. effective ingredient ephedrine,d-pseudo-ephedrine, volatile oil, in addition, 2，3，5，6-tetramethylpyrazine L-α-terpinenol.2. mechanism: promote the release of NA and Adr.Exciting β-R → activation Ac → promotion cAMP own produces.Stop the release of Anaphylactic mediator.Promote the release of PGE.Direct excited alpha-2-adrenoceptor → vasoconstriction → mucosa swelling alleviates.Suppressing antibody produces.3. the characteristics that act on are slow, gentle, lasting, can be oral.Diuresis: 1. effective ingredient d-pseudo-ephedrine.2. effect: the urine amount increases.3. mechanism: nephrectasia blood vessel → increase renal blood flow.Hinder the heavily absorption of renal tubules to sodium ion.Antiinflammatory, antiallergic: 1. effective ingredient pseudoephedrine, methylephedrine, ephedrine.2. the mechanism of action: suppress irritated mediator and discharge; Hemolysin reduces, and is anticomplementary action.Antitussive, eliminate the phlegm: 1. action intensity is codeine 1/20.2. effective ingredient terpinenol, Herba Ephedrae volatile oil.Analgesic, antibiotic, antiviral: 1. effective ingredient volatile oil.2. antibiotic staphylococcus aureus, first, beta hemolysis streptococcus, hemophilus influenza, Diplococcus pneumoniae, anthrax bacillus, diphtheria corynebacterium, escherichia coli, neisser's diplococcus.3. antiviral influenza virus.
Folium Perillae: suffering, temperature; Return lung, spleen channel.There is relieving the exterior syndrome by diaphoresis, regulating the flow of QI to ease the stomach, the effect of solving toxin of fish and crab.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen, the fish Eriocheir sinensis is poisoning." book on Chinese herbal medicine converge with speech ": Folium Perillae, cold expelling gas, lung heat clearing gas, alleviating distention in middle-JIAO gas, antiabortive gas, lower stagnation of QI, the gas that reduces phlegm, be control gas refreshing medicine also.Here one thing has three use: as the cold typhoid fever, and the headache osteodynia, fever with aversion to cold, podomere is unfavorable, or the beriberi hernia, and evil strongly fragrant the table person, Folium Perillae can fall apart heresy and induce sweat; Stagnation of QI knot and fullness in the epigastrium and abdomen painful abdominal mass plug, chest is unfavorable, or forces on nausea, abdomen side of body distending pain person, Caulis Perillae can be pleasant and alleviating distention in middle-JIAO; If or dyspnea due to adverse flow of lung-QI is contrary, Fructus Perillae can Dingchuan and the therapeutic method to keep the adverse QI flowing downwards, and phlegm-fire is run quickly and compeled, and Fructus Perillae can pathogenic fire reducing and clearing away phlegm, and three see difference used, method when in detail it.Water decoction with antibiotic effect Folium Perillae has inhibitory action to staphylococcus aureus; To all unrestraint effects such as bacillus pyocyaneus, Bacillus typhi, escherichia coli, paracolon, Song's Shigella flexneri and bacterium flexneri, anthrax bacillus. Folium Perillae extractum has bacteriostasis to fungus, wherein contained perillaldehyde, citral play main bacteriostasis, both also have mutual synergism, this is that its site of action is also similar because two kinds of compounds are all that monoterpene is aldehyde material.Perilla oil obviously is better than ethyl hydroxybenzoate to the mycete restraint of inoculation and natural pollution.
Herba Houttuyniae: acrid in the mouth, cold nature, enter lung, urinary bladder channel, has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, the effect of inducing diuresis for treating stranguria syndrome, for the lung abscess vomiting pus, the expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, the pyretic toxicity carbuncle sore, snakeworm is wanted first-class card.
Cortex Phellodendri: heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency." Chinese pharmacopoeia is carried the power of Cortex Phellodendri heat clearing and damp drying, similar to Radix Scutellariae, Rhizoma Coptidis, but take damp and hot as good except the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.
Fructus Forsythiae: hardship is slightly cold.Return lung, the heart, gallbladder meridian.Fructus Forsythiae has broad-spectrum antibacterial action, and staphylococcus aureus, Hayes dysentery bacterium are had to very strong inhibitory action, and other pathogenic bacterium, influenza virus, fungus are had to certain inhibitory action.Antiinflammatory action is arranged.The contained oleanolic acid of this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, prevents haemolysis.Decoct has the town effect of telling, anti-liver injury effect.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Cure mainly carbuncle sore tumefacting virus, the sucutaneous nodule scrofula, affection due to external wind and heat, epidemic febrile disease is from the beginning of, puckery pain of pyretic stranguria etc.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction, clearing away heart-fire.1. " herbal classic ": main cold and heat, Mus flaccidity, scrofula, carbuncle malignant boil, goiter, stagnation of pathogenic heat.2. " not Lu ": remove tapeworm.3. " property of medicine opinion ": main tonneau five types of stranguria, urinary obstruction, except heart man exopathogenic heat.4. " Japan hanako materia medica ": logical small intestinal, evacuation of pus.Control furuncle, pain relieving, logical menstruation.5. Li Gao: loose all menses stagnation of QI are poly-; Detumescence.6. Wang Haogu: control deaf Hun Hun Jun Jun.
Herba Taraxaci: the effect with resisting pathogenic microbes, Dandelion Injectable Solution has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus in vitro, and Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, Bacillus proteus, dysentery bacterium, Bacillus typhi etc. and micrococcus catarrhalis are also had to certain bactericidal action.Herba Taraxaci extract (1:400) can suppress tulase in vitro.Herba Taraxaci water decoction (1:80) can delay ECHO11 virocyte pathological changes.Taraxol extract 31mg/kg can kill leptospira.The water logging agent has inhibitory action to the various skin fungus.Decoct, to Oral Administration in Rats, absorbs well, in urine, can keep certain antibacterial action.Also have protect the liver, the effect of function of gallbladder promoting, by Herba Taraxaci decoct gavage or with the Dandelion Injectable Solution injection, the Glutamate pyruvate transaminase rises that carbon tetrachloride is caused has obvious inhibitory action; Can significantly alleviate the Histological change that the carbon tetrachloride liver damage causes.Have report to point out, Herba Taraxaci has choleretic effect in animals.Herba Taraxaci liquid gavage can make gallbladder contraction, and oddi's sphincter is lax, is conducive to bile and enters in intestinal.Effective to chronic gallbladder spasmolytic and calculosis clinically.Also there is immunologic function, the Herba Taraxaci decoct can significantly improve peripheral blood lymphocyte blast transformation rate in vitro, Taraxacum Polysaccharides can significantly strengthen ehrlich carcinoma and MM46 tumor-cell antigen induced mice callosity delayed hypersensitivity intensity, and administration time more effective characteristics are more backward arranged, i.e. administration on the 11st～20th after antigenic stimulus or 2～20 the next day administration obvious effect is arranged.The Taraxacum Polysaccharides lumbar injection can significantly strengthen the cytotoxicity of mouse antibodies dependency macrophage.
Rhizoma Osmundae: heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing cures mainly 1, anemopyretic cold, maculae caused by violent heat pathogen.This product bitter cold, the excess-heat can clearing heat in QI system divided, have the pyretic toxicity that can separate blood system, the card due to all warm malicious heresies all available it, often with Rhizoma Coptidis, Folium Isatidis, Radix Glycyrrhizae, be equal to use, as Rhizoma Osmundae fall apart (" Prescriptions for Universal Relief ").Single product or join Folium Mori, Flos Lonicerae etc. and can prevent and treat anemopyretic cold; If, with compatibilities such as Radix Isatidis, Folium Isatidis, Radix Arnebiae (Radix Lithospermi)s, can be used for again the diseases such as mumps, maculae caused by violent heat pathogen, dermexanthesis.2, heat in blood is hemorrhage.This product bitter in the mouth is slightly cold, and main enters Liver Channel, and the merit of cooling blood for hemostasis is arranged, and cures mainly epistaxis due to heat in blood, spits blood, has blood in stool, the disease such as metrorrhagia, the outstanding kind metrostaxis of controlling.As " Bencao Tujing " controls epistaxis, but single is ground into powder and is taken after mixing with liquid; If associate with Rhizoma Coptidis, grind the Oryza glutinosa drink into powder and be taken after mixing with liquid, can control haematemesis, as Rhizoma Osmundae loose (" Shengji Zonglu "); But treating hematochezia compatibility Cacumen Platycladi; Controlling metrostaxis can be with Oletum Trogopterori with using.3, worm disease.This product has the merit of parasite killing.For multiple Enterozoas such as killing and expelling tenia, ancylostome, pinworm, ascarids.Can use with the anthelmintic compatibility.4, this product also can be used for treating burn and scald and injures the married woman and be with inferior disease.
Radix Isatidis: the resisting pathogenic microbes effect: Radix Isatidis has inhibitory action to various bacteria.Infusion has inhibitory action in various degree to bacillus subtilis, staphylococcus aureus, sarcine, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery (will he, Fu Shi) bacillus, bacillus enteritidis etc.; The acetone leachate also has similar effect, and to Hemolytic streptococcus effective (all using agar aperture flat band method).Similar to the bacteriostasis of A type meningococcus and Bulbus Allii, Flos Lonicerae. infected by influenza PR8 strain and Jing Ke 68-1 strain have obvious inhibitory action.In vitro Radix Isatidis is killed leptospiral effect.To cardiovascular effect: these product can make the in vitro rabbit ear and rat lower limb perfusion flow increase, and improve the Rabbit Mesentery microcirculation, reduce the blood pressure of Anaesthetic Rabbits, reduce capillary permeability, and the mouse cardiac muscle oxygen consumption is descended.The Platelet Aggregation in Rabbits that anticoagulant effect Radix Isatidis is induced ADP has remarkable inhibitory action.Get the Platelet Aggregation in Rabbits that uridnine, hypoxanthine, pyrimidine, salicylic acid etc. induce ATP and also all show certain inhibition activity from Radix Isatidis, when 0.21mg/kg concentration, its suppression ratio is respectively 18.2%, 24.2%, 10.8% and 20%.Detoxication: for dog, Radix Isatidis, Rhizoma Coptidis powder and Rhizoma et radix veratri (Radix Rhizoma Veratri), with clothes (each 2.0g/kg), can be separated the Rhizoma et radix veratri (Radix Rhizoma Veratri) poison, reduce mortality rate; If use again it after veratrum poisoning, invalid; The alone Radix Isatidis powder of difference or Rhizoma Coptidis powder, effect is also bad." book on Chinese herbal medicine is stated ": hardship, cold, nontoxic." book on Chinese herbal medicine is just read ": enter liver, stomach blood system." China's book on Chinese herbal medicine ": return liver; The stomach warp.There is heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving effect.The treatment maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.
Folium Isatidis: be mainly used in pyretic toxicity and send out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.This medicine extensive use clinically in recent years, control above-mentioned all diseases except available, can be used for again expectorant heat stagnation lung, cough up phlegm yellow thick; Especially be usually used in popular second encephalitis, but both single was applied to prevention, can coordinate Radix Bupleuri, Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Radix Scrophulariae, the Radix Rehmanniae etc. again, can removing summer-heat the pyretic toxicity of edema caused by disorder of QI, battalion minute, availablely control various encephalitis b, and comparatively suitable with the partial heat type." detailed outline ": " main pyrotoxic dysentery, jaundice, sore throat, erysipelas." " LANYE juice is separated Mylabris, Yuan green grass or young crops, tree of heaven chicken, Cinnabaris, arsenicum sablimatum poison." " book on Chinese herbal medicine is just ": " and control the pestilence pyretic toxicity and go mad, the wind heat macule, carbuncle and ulcer swells and ache, relieving thirst and restlessness, only epistaxis, haematemesis, kill infantile malnutrition erosion, incised wound curare.All with the heat malicious person that holds concurrently, all should LANYE smash juice and use it.”
Radix Glycyrrhizae: property is flat, and sweet in the mouth, return 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong removing toxic substances arranged, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer, Radix Glycyrrhizae has blood fat reducing, antioxidative effect.
Semen Lepidii (Semen Descurainiae): suffering; Bitter; Cold.Return lung meridian; Heart channel; Liver Channel; The stomach warp; Urinary bladder channel.Function: eliminating the pathogens from the lung sending down the abnormal ascending QI; Eliminating phlegm and relieving asthma; Inducing diuresis to remove edema; Let out by evil.Cure mainly: sputum is stopped up the dyspnea and cough with excessive sputum of lung; Lung abscess; Edema; Breast abdomen hydrops; Dysuria; Chronic pulmonary heart disease; Breathing heavily of heart failure is swollen; Scrofula tuberculosis.
Rhizoma Polygoni Cuspidati: micro-hardship is slightly cold.Return liver, gallbladder, lung meridian.The function heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus." medical center bun will " carries it: hard kidney, and strong Yang yi Jing, strengthening bone and muscle, increase strength.Apply to get injured by a fall and lose place, but reunion of fractured tendons and bones.
Bulbus Fritillariae Cirrhosae: cool in nature, sweet flat.Enter lung meridian, stomach warp.Effect: nourishing the lung to arrest cough resolving phlegm and relieving asthma, removing heat-phlegm.1. effect (1) the antitussive effect Bulbus Fritillariae Cirrhosae of respiratory system had to antitussive effect.The experiment of employing ammonia induced cough in mice, tissue culture's Bulbus Fritillariae Cirrhosae and wild Bulbus Fritillariae Cirrhosae, the 3.0g/kg gavage, in the time of 30 minutes, antitussive effect is the strongest, and after the cough-relieving rate is greater than 50%, 1 hour, effect starts to descend, until within 2 hours, still have remarkable effect; Press 1.5g/kg and 3.0g/kg administration, cough suppressing effect strengthens and strengthens with dosage.Tissue culture's Bulbus Fritillariae Cirrhosae has similar relieving cough and resolving phlegm effect to commodity Bulbus Fritillariae Cirrhosae.Bulbus Fritillariae Cirrhosae total alkaloids and non-alkaloid part, oral administration, every Mus 0.25～0.5mg, all have obvious antitussive effect.In the dark violet Bulbus Fritillariae Uninbracteatae of and cultivation wild from the Northwest, river, the total alkaloids that proposes and Bulbus Fritillariae Uninbracteatae saponin I, II, III number, adopt mice sulfur dioxide to draw and cough the method experiment, and alkaloid has no antitussive effect; Bulbus Fritillariae Uninbracteatae Saponin II 0.2g/kg gavage, can obviously extend incubation period of mouse cough, performance antitussive effect.Separately there is the scholar to mix intraperitoneal anesthesia with pentobarbital sodium 15mg/kg and sodium phenobarbital 75mg/kg to cat, the electricity irritation superior laryngeal nerve is drawn the typical case and stable cough reaction, through the ethanol extract 4g/kg of lumbar injection Anhui shellfish (crude drug), pressed old terms stimulated every 20 minutes.The result demonstration, after medication, the cough intensity of cat and cough number of times all are subject to inhibition in various degree, within 60 minutes, produce significant antitussive effect, continue 2～3 hours.Relatively, both antitussive effects are without significant difference for Anhui shellfish and Bulbus Fritillariae Cirrhosae; And Anhui shellfish and Bulbus Fritillariae Thunbergii are relatively, the former antitussive effect obviously is better than the latter.Therefore the Anhui Becquerel is made the succedaneum of Bulbus Fritillariae Cirrhosae.(2) the phlegm-dispelling functions experimentation shows, family plants, Bulbus Fritillariae Cirrhosae wild, tissue culture all has obvious phlegm-dispelling functions.Adopt the phenol red excretion method experiment of mice, family plants and wild Bulbus Fritillariae Cirrhosae 200% fluid extract 25ml/kg, and Bulbus Fritillariae Cirrhosae alkaloid 11.3mg/kg and Bulbus Fritillariae Uninbracteatae saponin I～III 0.5mg/kg, all have more obvious expectorant effect, wherein stronger with the effect of alkaloid and Saponin III number.To mouse peritoneal injection 3.9g/kg group training Bulbus Fritillariae Cirrhosae and wild Bulbus Fritillariae Uninbracteatae water preparation, there is too phlegm-dispelling functions, after administration, 1 hour is the effect peak value, and after 2 hours, effect descends, and presses 1.5g/kg and 3.0g/kg administration, and its expectorant effect strengthens and strengthens with dosage.Give rat Anhui shellfish ethanol extract 15g/kg (crude drug) gavage or general glycoside 26mg/kg oral, result shows, after administration, the respiratory tract secretory volume significantly increases, and the general glycoside least effective dose (LED) is 12mg/kg, maximal effective dose is 59mg/kg, in this scope effect of eliminating the phlegm, with the increase of dosage, strengthens.2. to the effect of blood circulation, fritimine has hypotensive effect.Can produce the persistency blood pressure drops and accompany by of short duration respiration inhibition to cat intravenous injection fritimine 4.2mg/kg; Kashmirine also has hypotensive effect to anesthetized dog; Can make increased blood pressure when peimine and the peaceful minute quantity of peimine.But large number of biological alkali hyperamization drops.3. antibacterial action, Bulbus Fritillariae Cirrhosae has certain antibacterial action.During 2mg/l concentration, can suppress the growth and breeding of escherichia coli and staphylococcus aureus.Fritimine water logging agent (1: 25) has inhibitory action to star nocardia in vitro.4. toxic and side effects, (1) acute toxicity Anhui Bulbus Fritillariae Uninbracteatae ethanol extract 0.12mg/kg, to the cat lumbar injection, observes breathing, blood pressure and electrocardiogram all without change extremely.Give large and small Mus Anhui shellfish ethanol extract (or Anhui shellfish powder suspension is equivalent to 120 times of clinical amount) 12g/kg gavage, observe 7 days, the large and small Mus whole show of result is as usual, and hair color, feed are all in normal range.Mice Anhui shellfish ethanol extract gavage minimum lethal dose is 40g/kg, is more than 300 times of clinical application amount.(2) the long term toxicity test Cavia porcellus is 9,4 of rabbit, by the continuous gavage of Anhui shellfish ethanol extract 6g/kg 20 days, trachea, the heart, liver, lung, kidney, brain, esophagus, gastrointestinal, pancreas and adrenal gland etc. are done to the routine pathology cut sections for microscopic examination, see a large amount of hypertrophys of goblet cell in trachea and bronchial mucosa, secretions in tube chamber is obviously thin, and other organs is showed no ANOMALOUS VARIATIONS.
Toxicity test:
Select the SD rat, give the decoct of Chinese medicine composition of the embodiment of the present invention 3 of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, after the last administration, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half), and all the other 1/2 animals continue observation and live and kill after 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, and after administration, the index checkings such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology are carried out in 90 days and drug withdrawal in 2 weeks.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain all change without abnormal; Three dosage groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, between group without significant difference; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, connecting administration in 90 days according to result of the test Chinese medicine preparation of the present invention at high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) has no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, the convalescent period observation also has no the retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.
Clinical experiment
(1) material is prepared
Buy 400 of 21 aa broiler chicken from Jining of Shandong Province city Mou Ji plant, for prevention and therapeutic test.
Individual raiser provides 1105 of 20 Day-old Broiler Chickens of natural infection infectious bronchitis of chicken, picks out 300 of the sick chickens of manifest symptom, does therapeutic test.Gather the typical cytopathic tissues such as larynx, trachea, bronchus the chicken that dies of illness of this chicken group by the morbidity chicken group from doubtful infectious bronchitis, use conventional Embryo Gallus domesticus virus separation method, be separated to the virus of doubtful infectious bronchitis.Be diagnosed as the sick chicken of infectious bronchitis by the serological test such as AGP, ILT neutralization test and the test of viral physicochemical property and ILTV diagnosis of molecular biology method again.
(2) medicine
Chinese medicine is selected the Chinese medicine composition of embodiment 1-3, and wherein powder is dissolved in water into the oral liquid of 0.2mg/ml; Hydrochloric acid sarafloxacin reaches logical Pharmaceutical by Zhejiang to be provided, and is dissolved in water into the oral liquid of making 0.2mg/ml.
Chicken standard infectious laryngotracheitis kind poison is provided by Qingdao Hai Bo Bioisystech Co., Ltd, after multiple shape, uses.
(3) plant malicious rejuvenation
Get 20 SPF Embryo Gallus domesticus, laboratory is hatched to 10 ages in days.By sterile saline dilution in 1: 100 for the infectious bronchitis of chicken standard strain, through allantocherion vaccination, every embryo 0.2 mL, the chorioallantoic membrane of aseptic collection pathological changes and allantoic fluid after 72 h, chorioallantoic membrane is placed in tissue grinder, add gradually allantoic fluid, fully grind, after-20 ℃ of multigelations 4 times, add the 4000IU/mL penicillin and streptomycin, with centrifugal 15 min of the speed of 3 000 r/min, get supernatant, standby as kind of poison.
(4) prevention experimental technique
400 21 Day-old Broiler Chickens are raised to 35 ages in days in animal housing, select uniform 200 of health, body weight, be divided at random four groups of prophylactic counteracting toxic substances group 1, prophylactic counteracting toxic substances group 2, prophylactic counteracting toxic substances group 3, counteracting toxic substances matched group and blank groups, every group each 50, male and female ratio equalization, prophylactic counteracting toxic substances group 1-3 is respectively the oral liquid that gavages embodiment 1,2 and the decoct of embodiment 3, and the counteracting toxic substances matched group gavages the hydrochloric acid sarafloxacin prepared, and the blank group gavages normal saline.Every group of broiler gavages twice every day, gavage 5ml at every turn, for three days on end after, prophylactic counteracting toxic substances group 1-3 and counteracting toxic substances matched group are diluted to respectively the rejuvenation virus liquid of 10 ~ 5 concentration with sterile saline, every chicken tracheal instillation 0.2 mL carries out the artificial challenge, observes 6 d.
After counteracting toxic substances, chicken engenders rhinorrhea, sheds tears, and sneeze, hear obviously hoarse cry night, and drop-head closes order subsequently, lassitude, and the wing that hangs down squeezes heap, inappetence, the drink wish increases, and the phenomenon of indivedual chicken death is arranged.Through dead chicken is cutd open to inspection, in nasal cavity, trachea, bronchus, faint yellow translucent serosity, mucus exudate are arranged as seen, the air bag muddiness, enlargement appears in bronchus, bronchus and trachea intersection have the symptoms such as hemorrhage, be diagnosed as morbidity, otherwise for to prevent successfully.Record morbidity number, death toll, calculate sickness rate, mortality rate and protective rate.
(5) treatment experimental technique
300 of the sick chickens of natural infection infectious laryngotracheitis of chicken, be divided into three groups for the treatment of group A, treatment group B and matched groups, and treatment group A gavages the decoct of embodiment 3 by every of every day, every day 2 times; Treatment group B is by the feedstuff of every feeding embodiment 4 every day; Matched group gavages the hydrochloric acid sarafloxacin prepared, and every day 2 times, the treatment phase is 6 days, then observes 9 days, all cuts open afterwards inspection.
The clinical efficacy criterion: after treatment, sick chicken spirit, appetite recover normal, shed tears, the symptoms such as rhinorrhea, sneeze disappear fully, cut open the pathological change of inspection atypism, are recovery from illness, calculate cure rate.In therapeutic process, because infecting death, though during off-test dead cut open inspection still visible larynx and trachea pathological change hemorrhage, that ooze out is arranged, count and fail to respond to any medical treatment, account for the total ratio for the treatment of according to invalid number and calculate inefficiency.
(6) feeding and management of experimental animal
Broiler adopts online flat supporting, and respectively organizes the conditionally completes such as feedstuff, drinking-water, illumination and feeding and management at whole duration of test identical, and carries out conventional environment disinfected.The sick chicken of natural infection is for raising in cages, the same premorbid of feeding and management during treatment.
(7) result
A, prevention experimental result
Table 1 prevention experimental result
| Group | Chicken sum (only) | Morbidity number (only) | Sickness rate (%) | Death toll (only) | Mortality rate (%) | Protective rate (%) |
| Prevention counteracting toxic substances group 1 | 40 | 1 | 2.5 | 0 | 0 | 97.5 |
| Prevention counteracting toxic substances group 2 | 40 | 3 | 7.5 | 0 | 0 | 92.5 |
| Prevention counteracting toxic substances group 3 | 40 | 2 | 5 | 0 | 0 | 95 |
| The counteracting toxic substances matched group | 40 | 40 | 100 | 17 | 42.5 | 0 |
| The blank group | 40 | 0 | 0 | 0 | 0 | - |
From table 1, can find out, the morbidity sum of prophylactic counteracting toxic substances group 1-3 is well below the counteracting toxic substances matched group, without dead.The protective rate of prophylactic counteracting toxic substances group 1-3 is 97.5%, 92.5% and 95%.And the morbidity of counteracting toxic substances matched group adds up to 40, sickness rate is 100%, and death toll is 17, and sick chicken death rate is 42.5%.The blank group is without the morbidity chicken.Chinese medicine composition of the present invention is described, the respiratory tract disease of chicken especially infectiousness larynx bronchitis is had to good preventive effect, protective rate is very high.
B, treatment experimental result
Table 2 treatment natural infection infectious bronchitis chicken situation
| Group | Chicken sum (only) | Death toll (only) | Mortality rate (%) | Inefficiency (%) | Recovery from illness number (only) | Cure rate (%) |
| Treatment group 1 | 100 | 3 | 3 | 9 | 91 | 91 |
| Treatment group 2 | 100 | 2 | 2 | 7 | 93 | 93 |
| Matched group | 100 | 18 | 18 | 41 | 59 | 59 |
From table 2, can find out, the natural infection chicken is with in traditional Chinese medicine composition for treating process of the present invention, and rhinorrhea, the symptom such as shed tears alleviate gradually or disappear; Spirit, search for food, drink water gradually and to recover normal or normal; Appetite obviously strengthens, and feces also transfers to normally.By the 15th day after medication, all ill chickens are basic all cured, and cure rate reaches 91%, and body weight also rises gradually.By therapeutic test, prove, Chinese medicine composition of the present invention has good curative effect to infectious bronchitis of chicken.
To sum up, the Chinese medicine composition of employing embodiment of the present invention 1-3 and the feedstuff of embodiment 4, can be good at especially infectious bronchitis of chicken of prevention and treatment respiratory disease of chicken, improves chicken autoimmunity, safe and effective, can reach the purpose of the strong body that gets rid of illness.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (9)
1. the Chinese medicine composition that is used for the treatment of respiratory disease of chicken, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Radix Scutellariae 5-15 part, Herba Ephedrae 3-18 part, Folium Perillae 3-10 part, Herba Houttuyniae 4-17 part, Cortex Phellodendri 2-10 part, Fructus Forsythiae 3-14 part, Herba Taraxaci 2-14 part, Rhizoma Osmundae 2-17 part, Radix Isatidis 3-22 part, Folium Isatidis 3-18 part and Radix Glycyrrhizae 4-16 part.
2. the Chinese medicine composition that is used for the treatment of respiratory disease of chicken according to claim 1, is characterized in that, described Chinese medicine composition also comprises: Semen Lepidii (Semen Descurainiae), Rhizoma Polygoni Cuspidati and Bulbus Fritillariae Cirrhosae; In described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Radix Scutellariae 5-15 part, Herba Ephedrae 4-18 part, Folium Perillae 3-10 part, Herba Houttuyniae 5-16 part, Cortex Phellodendri 3-9 part, Fructus Forsythiae 4-12 part, Herba Taraxaci 3-14 part, Rhizoma Osmundae 3-15 part, Radix Isatidis 5-20 part, Folium Isatidis 5-17 part, Radix Glycyrrhizae 5-15 part, Semen Lepidii (Semen Descurainiae) 1-9 part, Rhizoma Polygoni Cuspidati 1-10 part and Bulbus Fritillariae Cirrhosae 2-9 part.
3. the Chinese medicine composition that is used for the treatment of respiratory disease of chicken according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Radix Scutellariae 8-15 part, Herba Ephedrae 4-12 part, Folium Perillae 5-10 part, Herba Houttuyniae 5-12 part, Cortex Phellodendri 3-6 part, Fructus Forsythiae 4-7 part, Herba Taraxaci 8-14 part, Rhizoma Osmundae 9-15 part, Radix Isatidis 11-20 part, Folium Isatidis 9-17 part, Radix Glycyrrhizae 5-11 part, Semen Lepidii (Semen Descurainiae) 1-5 part, Rhizoma Polygoni Cuspidati 6-10 part and Bulbus Fritillariae Cirrhosae 5-9 part.
4. according to the described Chinese medicine composition that is used for the treatment of respiratory disease of chicken of claim 1-3 any one, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Radix Scutellariae 5-11 part, Herba Ephedrae 9-18 part, Folium Perillae 3-8 part, Herba Houttuyniae 8-16 part, Cortex Phellodendri 5-9 part, Fructus Forsythiae 6-12 part, Herba Taraxaci 3-11 part, Rhizoma Osmundae 3-11 part, Radix Isatidis 5-14 part, Folium Isatidis 5-11 part, Radix Glycyrrhizae 8-15 part, Semen Lepidii (Semen Descurainiae) 4-9 part, Rhizoma Polygoni Cuspidati 1-7 part and Bulbus Fritillariae Cirrhosae 2-7 part.
5. according to the described Chinese medicine composition that is used for the treatment of respiratory disease of chicken of claim 1-4 any one, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Radix Scutellariae 7-13 part, Herba Ephedrae 6-16 part, Folium Perillae 4-8 part, Herba Houttuyniae 7-13 part, Cortex Phellodendri 3-9 part, Fructus Forsythiae 4-12 part, Herba Taraxaci 3-12 part, Rhizoma Osmundae 3-15 part, Radix Isatidis 5-20 part, Folium Isatidis 5-15 part, Radix Glycyrrhizae 5-15 part, Semen Lepidii (Semen Descurainiae) 3-7 part, Rhizoma Polygoni Cuspidati 3-6 part and Bulbus Fritillariae Cirrhosae 4-7 part.
6. according to the described Chinese medicine composition that is used for the treatment of respiratory disease of chicken of claim 1-5 any one, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: 5 parts of 10 parts of Radix Scutellariaes, 12 parts, Herba Ephedrae, 6 parts of Folium Perillaes, 10 parts of Herba Houttuyniae, 6 parts of Cortex Phellodendris, 8 parts of Fructus Forsythiaes, 7 parts of Herba Taraxacis, 9 parts of Rhizoma Osmundae, 12 parts of Radix Isatidis, 10 parts of Folium Isatidiss, 10 parts, Radix Glycyrrhizae, 5 parts of Semen Lepidii (Semen Descurainiae)s, 5 parts of Rhizoma Polygoni Cuspidati and Bulbus Fritillariae Cirrhosaes.
7. a preparation method that is used for the treatment of the Chinese medicine composition of respiratory disease of chicken as described as claim 1-6 any one, is characterized in that, the dosage form of described Chinese medicine composition is powder, and described preparation method comprises the following steps:
(1) take all raw medicinal materials according to ratio of weight and number, after pulverizing, drop into blender and stir 40-60 minute, fully mix to obtain mixture;
(2) add the water with respect to 2～4 times of mixture qualities in mixture, decoct 2～4 hours, filter, add the water with respect to 1～2 times, mixture in filtering residue, again decoct 1～2 hour, filter, twice filtrate is mixed, concentrating under reduced pressure is removed moisture, obtain dry mastic, further and pulverizing dry with spray dryer, sieve and obtain 50～100 order fine powders, obtains powder.
8. a feedstuff, is characterized in that, described feedstuff comprises feed additive and feed vector, and described feed additive comprises that the described Chinese medicine composition of claim 1-7 any one is as feed additive.
9. feedstuff according to claim 8, is characterized in that, with respect to the feed additive of 100 weight portions, the addition of described Chinese medicine additive is the 10-20 weight portion.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641102A (en) * | 2014-11-19 | 2016-06-08 | 天津嘉创生物科技有限公司 | An oral liquid for treating chicken respiratory tract diseases and a preparing method thereof |
| CN106138665A (en) * | 2015-04-15 | 2016-11-23 | 沈阳伟嘉牧业技术有限公司 | A kind of Chinese medicine composition for treating chicken pneumonia |
| CN106138322A (en) * | 2015-04-08 | 2016-11-23 | 汤晓芳 | A kind of medicine treating infectious bronchitis of chicken |
| CN107981090A (en) * | 2017-12-14 | 2018-05-04 | 阜阳市玉琪农业科技有限公司 | A kind of feed for preventing chicken respiratory tract disease and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332256A (en) * | 2007-06-28 | 2008-12-31 | 保定冀中药业有限公司 | Traditional Chinese medicine composition for infectious bursal disease and preparation method thereof |
| CN101804116A (en) * | 2010-04-22 | 2010-08-18 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine for preventing and treating nephropathogenic infectious bronchitis in chicken and preparation method thereof |
| KR20120032312A (en) * | 2010-09-28 | 2012-04-05 | 한국 한의학 연구원 | Composition for drinking water or feed additive |
| CN102836290A (en) * | 2012-09-15 | 2012-12-26 | 广西嘉进药业有限公司 | Chinese herbal tea for preventing and treating flu |
-
2013
- 2013-09-23 CN CN201310434108.7A patent/CN103494927B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332256A (en) * | 2007-06-28 | 2008-12-31 | 保定冀中药业有限公司 | Traditional Chinese medicine composition for infectious bursal disease and preparation method thereof |
| CN101804116A (en) * | 2010-04-22 | 2010-08-18 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine for preventing and treating nephropathogenic infectious bronchitis in chicken and preparation method thereof |
| KR20120032312A (en) * | 2010-09-28 | 2012-04-05 | 한국 한의학 연구원 | Composition for drinking water or feed additive |
| CN102836290A (en) * | 2012-09-15 | 2012-12-26 | 广西嘉进药业有限公司 | Chinese herbal tea for preventing and treating flu |
Non-Patent Citations (3)
| Title |
|---|
| 朱连勤等: "中药防治鸡传染性呼吸道疾病的研究现况与展望", 《中兽医学杂志》, no. 4, 31 December 2003 (2003-12-31) * |
| 李邦模等: "《养鸡秘诀》", 30 April 2004, article "鸡呼吸道疾病" * |
| 苗明三等: "《对药的化学、药理与临床》", 30 April 2002, article "苏子 葶苈子", pages: 224 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105641102A (en) * | 2014-11-19 | 2016-06-08 | 天津嘉创生物科技有限公司 | An oral liquid for treating chicken respiratory tract diseases and a preparing method thereof |
| CN106138322A (en) * | 2015-04-08 | 2016-11-23 | 汤晓芳 | A kind of medicine treating infectious bronchitis of chicken |
| CN106138665A (en) * | 2015-04-15 | 2016-11-23 | 沈阳伟嘉牧业技术有限公司 | A kind of Chinese medicine composition for treating chicken pneumonia |
| CN107981090A (en) * | 2017-12-14 | 2018-05-04 | 阜阳市玉琪农业科技有限公司 | A kind of feed for preventing chicken respiratory tract disease and preparation method thereof |
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| CN103494927B (en) | 2014-12-03 |
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Address after: No. 1, Jiuxu Avenue, Suining Economic Development Zone, Xuzhou City, Jiangsu Province, 221200 Patentee after: Xuzhou Tianyi Animal Pharmaceutical Co.,Ltd. Address before: 221000 Area A, South Ring Road Industrial Park, Suining County, Xuzhou, Jiangsu Province (Zhouzhuang Group, Huyuan Village, Suicheng Town) Patentee before: XUZHOU TIANYI ANIMAL PHARMACEUTICAL CO.,LTD. |