CN105641102A - An oral liquid for treating chicken respiratory tract diseases and a preparing method thereof - Google Patents
An oral liquid for treating chicken respiratory tract diseases and a preparing method thereof Download PDFInfo
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- CN105641102A CN105641102A CN201410664460.4A CN201410664460A CN105641102A CN 105641102 A CN105641102 A CN 105641102A CN 201410664460 A CN201410664460 A CN 201410664460A CN 105641102 A CN105641102 A CN 105641102A
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Abstract
The invention relates to an oral liquid for treating chicken respiratory tract diseases and a preparing method thereof. The oral liquid comprises 10-15 parts by weight of a spine date seed extract product, 5-10 parts by weight of a baical skullcap root extract product, 1-2 parts by weight of sodium sulfite, 1-3 parts by weight of cane sugar and 1-2 parts by weight of Tween-80. The oral liquid has significant treating effects for the chicken respiratory tract diseases caused by pathogenic microorganisms and bacteria, and is capable of boosting body immunity, promoting animal growth and development and improving safe production performance of animals.
Description
Technical field
The invention belongs to field of veterinary, especially one treats respiratory disease of chicken oral liquid and its preparation method.
Background technology
The respiratory tract disease of chicken is a kind of disease based on respiratory symptom, mainly shows as the respiratory symptoms such as asthma, nasal obstruction, sneeze. Cause the reason also more complicated of respiratory disease of chicken, its major cause has (1) physiologic factor, owing to poultry carries out the physilogical characteristics of gaseous interchange with air bag, make poultry than the infringement being easier to be subject to extraneous obnoxious flavour, dust, microorganism etc., cause respiratory tract injury and fall ill. (2) cause pathogeny imcrobe infection, mainly because chicken bacteriosis (such as salmonellosis, infective rhinitis, colibacillosis etc.) and virus disease (such as newcastle disease, bird flu, fowl pox etc.) infect and cause. (3) environmental health and feeding and management are not good at, mainly because of damp and hot, improper ventilation, hen house density are excessive etc. stress the respiratory symptom that causes of reason. The morbidity of this disease is rapid, velocity of propagation is fast and difficulty prevents and treats mortality ratio height, brings serious loss to poultry large-scale cultivation, and this not only hinders the sound development of livestock industry, also result in the public health accident that comparison is serious. The respiratory tract disease of current chicken constantly increases, and clinical conventional antibiotic medicine is relatively more frequent owing to using, and defines resistance gradually, the usage quantity of medicine is also being increased, and this makes aquaculture cost raise, and drug residue is more serious. Therefore, the medicine of development of new high-efficiency prevention and control fowl respiratory disease is imperative.
Summary of the invention
It is an object of the invention to provide one and treat respiratory disease of chicken oral liquid, the respiratory tract disease of the chicken caused by multiple reason can effectively be treated by this oral liquid, and can improve the immunizing power of animal body.
Another object of the present invention is to provide a kind of preparation method treating respiratory disease of chicken oral liquid.
The present invention is achieved through the following technical solutions:
One treats respiratory disease of chicken oral liquid, and component and the ratio of weight and number thereof of its oral liquid are respectively:
And the component of this oral liquid and optimum ratio of weight and number thereof are:
Treating a preparation method for respiratory disease of chicken oral liquid, its step is as follows:
(1) take appropriate Spina Date Seed to pulverize, add the sherwood oil soak degreasing of 8 times of Spina Date Seed weight, the Spina Date Seed sediment obtained carries out soak extraction with 10 times of weight 80% ethanol, extract 3 times continuously, each 3 hours, merging filtrate, reclaimed ethanol, concentrated steaming is done to powder and is obtained Semen Ziziphi Spinosae extract, for subsequent use;
(2) take the appropriate root of large-flowered skullcap to pulverize, the ethanol adding 8 times of root of large-flowered skullcap weight 70% carries out refluxing extraction, extract 3 times continuously, each 2h, collects and filters, merging filtrate, with isopyknic petroleum ether extraction 3 times after concentrating under reduced pressure, and then use n-butanol extraction alcoholic solution, and concentrated for extraction liquid steaming is done to powder and obtain Radix Scutellariae extract, for subsequent use;
(3) step (1) is taken by weight ratio respectively and Spina Date Seed that step (2) obtains and Radix Scutellariae extract, and spray disintegrating apparatus with supersonic airstream and make super-fine powder, the particle diameter of two kinds of extract micropowders is less than 75um, obtains mixture A, for subsequent use;
(4) take sucrose, S-WAT, twen-80 respectively according to weight proportion, join respectively in step (3) gained mixture A, mix 25 minutes at normal temperatures with three-dimensional mixer, obtain mixture B, for subsequent use;
(5) being dissolved in the purified water of its 2 times amount volume by the mixture B of step (4) gained, abundant stirring and evenly mixing, after filtration, envelope filling, sterilizing, must treat respiratory disease of chicken oral liquid finished product.
The advantage of the present invention has:
(1) compared to traditional herbal medicine, oral liquid environmental protection of the present invention, having no side effect and drug residue and good palatability, bioavailability height, meanwhile, in prescription, the active constituent content of key agents is higher, and curative effect of medication is good.
(2) respiratory disease of chicken caused because of various reason is not only had result for the treatment of significantly by oral liquid of the present invention, and can improve animal body immunizing power, and effectively control chicken immune suppresses the generation of disease, enhancing development, raising production performance.
Embodiment
The present invention is described in further detail by following examples. It should be understood that following embodiment is explanation property, it not limited, protection scope of the present invention can not be limited with following embodiment.
Embodiment 1
Treating a respiratory tract disease oral liquid for chicken, its oral liquid component and weight thereof are respectively: Semen Ziziphi Spinosae extract 10g; Radix Scutellariae extract 5g; S-WAT 1g, sucrose 1g; Tween-80 1g.
(1) take appropriate Spina Date Seed to pulverize, add the sherwood oil soak degreasing of 8 times of Spina Date Seed weight, the Spina Date Seed sediment obtained carries out soak extraction with 10 times of weight 80% ethanol, extract 3 times continuously, each 3 hours, merging filtrate, reclaimed ethanol, concentrated steaming is done to powder and is obtained Semen Ziziphi Spinosae extract, for subsequent use;
(2) take the appropriate root of large-flowered skullcap to pulverize, the ethanol adding 8 times of root of large-flowered skullcap weight 70% carries out refluxing extraction, extract 3 times continuously, each 2h, collects and filters, merging filtrate, with isopyknic petroleum ether extraction 3 times after concentrating under reduced pressure, and then use n-butanol extraction alcoholic solution, and concentrated for extraction liquid steaming is done to powder and obtain Radix Scutellariae extract, for subsequent use;
(3) step (1) is taken by weight ratio respectively and Spina Date Seed that step (2) obtains and Radix Scutellariae extract, and spray disintegrating apparatus with supersonic airstream and make super-fine powder, the particle diameter of two kinds of extract micropowders is less than 75um, obtains mixture A, for subsequent use;
(4) take sucrose, S-WAT, twen-80 respectively according to weight proportion, join respectively in step (3) gained mixture A, mix 25 minutes at normal temperatures with three-dimensional mixer, obtain mixture B, for subsequent use;
(5) being dissolved in the purified water of its 2 times amount volume by the mixture B of step (4) gained, abundant stirring and evenly mixing, after filtration, envelope filling, sterilizing, must treat respiratory disease of chicken oral liquid finished product.
Embodiment 2
Treating a respiratory tract disease oral liquid for chicken, its oral liquid component and weight thereof are respectively: Semen Ziziphi Spinosae extract 15g; Radix Scutellariae extract 10g; S-WAT 2g, sucrose 3g; Tween-80 2g.
The step of its preparation method is with embodiment 1.
Embodiment 3
Treating a respiratory tract disease oral liquid for chicken, its oral liquid component and weight thereof are respectively: Semen Ziziphi Spinosae extract 13g;Radix Scutellariae extract 8g; S-WAT 1g, sucrose 2g; Tween-80 2g.
The step of its preparation method is with embodiment 1.
Clinical application is tested
In order to verify that oral liquid of the present invention is to the result for the treatment of of respiratory tract disease, we have carried out the test of manual-induced infection treatment of respiratory diseases in poulty house, Mare Tranquillitatis, Tianjin. In test, oral liquid of the present invention has carried out comparitive study with the conventional medicine for the treatment of respiratory disease of chicken, thus evaluates this oral liquid to the result for the treatment of of respiratory disease of chicken.
1 materials and methods
1.1 trial drug
Test oral liquid has our company to prepare.
Norfloxicin water solube powder, specification: 100g, purchased from Tianjin Jin Fa veterinary drug company limited;
Compound florfenicol, specification: 100g, purchased from Henan Sen Long veterinary drug company limited.
1.2 reagent
FM-4 substratum, prepares according to the culture method of FreyShi, illustratively prepares nutrient broth.
1.3 bacterial strain
Chicken virus mycoplasma S6 strain (MGS6) is provided by China's veterinary medicament supervision. By consulting document, by strong virus mycoplasma S6 bacterial strain through FM-4 substratum Secondary Culture 3 times, making unit is 109CCU/mL, inoculation mycoplasma liquid.
1.4 laboratory animal
Parts in Beijing opera spoken in Beijing dialect chick 100, aseptically raises routinely, does not add any antibacterials, raise to age on the 35th in feeding feed stuff and drinking-water.
1.5 test methods and packet transaction
To the preparation chicken in age on the 35th, select health from raising, 75 chick that body weight is suitable, it is divided into 5 groups at random, often organize 15, carrying out packet transaction the 1st group by table 1 is oral liquid treatment group of the present invention, 2nd group is norfloxacin in treatment group, 3rd group is compound florfenicol treatment group, and the 4th group is positive controls, and the 5th group is blank group; Except blank group, other are respectively organized and all inoculate mycoplasma bacterium liquid 0.5mL by chicken left and right torso bag, after there is clinical symptom in inoculation, 1-3 group presses 1mL/L, 1.0g/L, 1.2g/L drinking water administration respectively, twice daily, 4th, the 5th group does not process, and successive administration 5 days, administration observes clinical symptom and record after terminating.
1.6 curative effect judging standard
Curing: clinical symptom completely dissolve after medication is treated, the spiritual appetite of chicken recovers normal;
Effective: after medication is treated, sick chicken sheds tears, respiratory tract blocks, the sound of vomiting sound, sneeze, cough
Alleviating etc. symptom, spirit appetite obviously takes a turn for the better.
Invalid: the diseases such as after treatment, sick chicken sheds tears, respiratory tract blocks, the sound of vomiting sound, sneeze, cough chicken
Shape is not improved, and aggravation or death occurs, and test terminates rear statistical computation and cures
Rate, there are efficiency and inefficiency.
Average growth rate: rate of body weight gain (%)=(heavy-average just body weight of average opisthosoma)/average just body weight �� 100%
Body weight increase rate: body weight increase rate (%)=test group average growth rate/normal healthy controls group average growth rate �� 100%
1.7 data analysis
Data test of significance is carried out with statistical method.
2. test-results
2.1 clinical symptom and pathology
Each group test chicken after inoculation mycoplasma S6 germ the 4th day, start to occur the spiritual depressed, dispirited of not degree, the symptoms such as poor appetite, within the 5 to 6 day, most of chicken shows obvious respiratory symptom, as cough, have a running nose, sneeze and because respiratory tract blocking and have difficulty in breathing, breathing etc. of opening one's mouth. The dead visible face swelling of sick chicken, has eye conjunctivitis and oedema phenomenon, cuts open inspection and finds that nasal cavity and organ have mucus secretory product mucus exudate, and air bag wall thickening muddiness has the cheesy thing of yellow-white. Within latter 5 days, 12 are had because infecting mycoplasma and death to experiment end from attacking poison.Test each group of chicken the mental status and appetite all significantly better than infection control group, in 3 treatment groups, the chicken mental status of oral liquid group of the present invention and appetite level off to blank group, and result for the treatment of is best in each group.
2.2 clinical trial results
Oral liquid of the present invention, norfloxicin soluble powder and compound florfenicol to the result for the treatment of of test chicken respiratory tract disease in table 1.
Test efficacy result respectively organized by table 1
Through statistical analysis, artificial challenge is brought out there is efficiency and infecting control group comparing difference extremely significantly (P < 0.01) of respiratory disease of chicken by oral liquid group of the present invention and norfloxicin group; Artificial challenge is brought out there is efficiency and infecting control group comparing difference significantly (P < 0.05) of respiratory disease of chicken by compound florfenicol group; Oral liquid group of the present invention have efficiency and norfloxicin group and florfenicol group comparing difference significantly (P < 0.05).
Oral liquid group of the present invention and the body weight increase rate of norfloxicin group difference extremely remarkable (P < 0.01) compared with infecting control group; The body weight increase rate of compound florfenicol group is significant difference (P < 0.05) compared with infecting control group; Oral liquid group body weight increase rate of the present invention is significantly higher than norfloxicin group and florfenicol group (P < 0.05).
3. conclusion
Being shown by above test-results, treatment respiratory disease of chicken is had significant curative effect by oral liquid of the present invention.
Claims (3)
1. a treatment respiratory disease of chicken oral liquid, it is characterised in that, component and the ratio of weight and number thereof of this oral liquid are respectively:
2. treatment respiratory disease of chicken oral liquid according to claim 1, it is characterised in that: the component of this oral liquid and optimum ratio of weight and number thereof be:
3. treat the preparation method of respiratory disease of chicken oral liquid as claimed in claim 1 for one kind, it is characterised in that: the step of this preparation method is as follows:
(1) take appropriate Spina Date Seed to pulverize, add the sherwood oil soak degreasing of 8 times of Spina Date Seed weight, the Spina Date Seed sediment obtained carries out soak extraction with 10 times of weight 80% ethanol, extract 3 times continuously, each 3 hours, merging filtrate, reclaimed ethanol, concentrated steaming is done to powder and is obtained Semen Ziziphi Spinosae extract, for subsequent use;
(2) take the appropriate root of large-flowered skullcap to pulverize, the ethanol adding 8 times of root of large-flowered skullcap weight 70% carries out refluxing extraction, extract 3 times continuously, each 2h, collects and filters, merging filtrate, with isopyknic petroleum ether extraction 3 times after concentrating under reduced pressure, and then use n-butanol extraction alcoholic solution, and concentrated for extraction liquid steaming is done to powder and obtain Radix Scutellariae extract, for subsequent use;
(3) step (1) is taken by weight ratio respectively and Spina Date Seed that step (2) obtains and Radix Scutellariae extract, and spray disintegrating apparatus with supersonic airstream and make super-fine powder, the particle diameter of two kinds of extract micropowders is less than 75um, obtains mixture A, for subsequent use;
(4) take sucrose, S-WAT, twen-80 respectively according to weight proportion, join respectively in step (3) gained mixture A, mix 25 minutes at normal temperatures with three-dimensional mixer, obtain mixture B, for subsequent use;
(5) being dissolved in the purified water of its 2 times amount volume by the mixture B of step (4) gained, abundant stirring and evenly mixing, after filtration, envelope filling, sterilizing, must treat respiratory disease of chicken oral liquid finished product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410664460.4A CN105641102A (en) | 2014-11-19 | 2014-11-19 | An oral liquid for treating chicken respiratory tract diseases and a preparing method thereof |
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| CN201410664460.4A CN105641102A (en) | 2014-11-19 | 2014-11-19 | An oral liquid for treating chicken respiratory tract diseases and a preparing method thereof |
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| CN101401876A (en) * | 2008-11-10 | 2009-04-08 | 寇雪军 | Chinese medicinal composition for treating upper respiratory tract infection |
| CN101810820A (en) * | 2009-11-16 | 2010-08-25 | 天津瑞贝特科技发展有限公司 | Livestock and poultry traditional Chinese medicine composition with function of clearing heat and eliminating phlegm and preparation method thereof |
| CN102119977A (en) * | 2011-03-03 | 2011-07-13 | 天津瑞贝特科技发展有限公司 | Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof |
| CN102994231A (en) * | 2012-10-25 | 2013-03-27 | 罗瑞雪 | Preparation method of flavor for baicalin tobaccos |
| CN103494927A (en) * | 2013-09-23 | 2014-01-08 | 胡洪杰 | Traditional Chinese medicine composition for treating chicken respiratory disease and preparation method thereof |
| CN103656482A (en) * | 2012-09-25 | 2014-03-26 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition with functions of clearing heat and resolving phlegm for livestock and preparation method thereof |
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2014
- 2014-11-19 CN CN201410664460.4A patent/CN105641102A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401876A (en) * | 2008-11-10 | 2009-04-08 | 寇雪军 | Chinese medicinal composition for treating upper respiratory tract infection |
| CN101810820A (en) * | 2009-11-16 | 2010-08-25 | 天津瑞贝特科技发展有限公司 | Livestock and poultry traditional Chinese medicine composition with function of clearing heat and eliminating phlegm and preparation method thereof |
| CN102119977A (en) * | 2011-03-03 | 2011-07-13 | 天津瑞贝特科技发展有限公司 | Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof |
| CN103656482A (en) * | 2012-09-25 | 2014-03-26 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition with functions of clearing heat and resolving phlegm for livestock and preparation method thereof |
| CN102994231A (en) * | 2012-10-25 | 2013-03-27 | 罗瑞雪 | Preparation method of flavor for baicalin tobaccos |
| CN103494927A (en) * | 2013-09-23 | 2014-01-08 | 胡洪杰 | Traditional Chinese medicine composition for treating chicken respiratory disease and preparation method thereof |
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Application publication date: 20160608 |