CN102119977A - Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof - Google Patents
Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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Abstract
The invention relates to a Chinese medicinal infusion solution for treating bovine mastitis. The Chinese medicinal infusion solution comprises the following components in parts by weight: 1 to 10 parts of dark plum extract, 1 to 10 parts of wild jujube seed extract, 1 to 10 parts of houttuynia herb extract, 5 to 30 parts of absolute alcohol, and 10 to 50 parts of purified water. The infusion solution has high response speed, no toxic or side effect, no medicament residue, convenience in use, saving of culture cost, simplified operation and high bioavailability, and is a Chinese medicinal infusion solution for according with a safe veterinary medicament, ensuring the safety requirement of animal-derived food and treating the bovine mastitis.
Description
Technical field
The invention belongs to field of veterinary, especially a kind of Chinese medicinal perfusion liquid for the treatment of mammitis of cow and preparation method thereof.
Background technology
Mammitis of cow is one of milch cow common frdquently encountered disease, and this sick pathogen has kind more than 80～130, and wherein main cause of disease is streptococcus agalactiae, streptococcus dysgalactiae, staphylococcus aureus, Mycoplasma, streptococcus uberis, escherichia coli etc.Mammitis of cow generally is divided into two kinds: 1, latent mammitis, the self-defense mechanism of its their early stage body and cause of disease are carried out the fierceness fight, redness, burning pain performance do not appear in the mammary gland outside, the quality of milk does not have ANOMALOUS VARIATIONS from seeing in appearance yet, but can see that the somatic cell quantity in the milk exceeds 500,000/mL during lab analysis; 2, clinical property mastitis, its mammary gland and milk all have unusual performance: cotton-shaped milk slag, grumeleuse and water sample milk surum appear in milk.The infected breast unexpected swelling in district when acute mastitis takes place, little red, the heating of skin, hardening.Fervescence, more than the body temperature rise to 41 ℃, pulse is accelerated sometimes, rapid breathing, spirit depressing, inappetence, along with the course of disease development skeletonize, do not rise with crouching.When serious, enophthalmos, foul defecation, in the flue, dead because of septicemia at last.The U.S. according to the prosperity of data statistics dairy has 1,100 ten thousand cows in milk now, suffer from reaching about 50% of latent mammitis, the investigation of ground such as China Beijing, Shanghai finds that the bovine subclinical mastitis sickness rate is about 60%, because annual 1526.25 yuan of every ill cattle of the loss that causes of mammitis of cow, being not difficult to analyze mammitis of cow has been one of major reason that causes milch cow production economic loss in China.At present generally adopt antibiotic for the treatment of mammitis of cow, though can play certain therapeutic effect, drug residue and pollution animal-derived food problem are serious, and stimulate injury bigger to cultivated animals, and stress is strong.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicinal perfusion liquid for the treatment of mammitis of cow, this infusion liquid onset speed is fast, have no side effect, drug residue free, and is easy to use, saves aquaculture cost, simplifies the operation the bioavailability height.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicinal perfusion liquid of mammitis of cow.
The present invention is achieved by the following technical solutions:
A kind of Chinese medicinal perfusion liquid for the treatment of mammitis of cow, the component of its Chinese medicine infusion liquid and ratio of weight and number thereof are:
Fructus Mume extract 1-10 part;
Semen Ziziphi Spinosae extracts 1-10 part;
Herba Houttuyniae extract 1-10 part;
Dehydrated alcohol 5-30 part;
Purified water 10-50 part.
A kind of preparation method for the treatment of the Chinese medicinal perfusion liquid of mammitis of cow, the step of its preparation method is as follows:
(1). take by weighing Semen Ziziphi Spinosae and pulverize, then with the petroleum ether soak degreasing of 6-8 times of Semen Ziziphi Spinosae weight, the Semen Ziziphi Spinosae sediment that obtains uses 6-10 times of weight 60-80% ethanol to soak extraction, 3-4 time continuously, each 3-5 hour, collect filtrate, reclaim ethanol, the concentrate drying ointment, it is standby both to have got Semen Ziziphi Spinosae extract;
(2). take by weighing Fructus Mume and pulverize,, obtain the Fructus Mume sediment and use 1-4 times of n-butyl alcohol to soak extraction then with the petroleum ether soak degreasing of 6-8 times of Fructus Mume weight, 1-4 time continuously, each 1-4 hour, collect filtrate, reclaim n-butyl alcohol, the concentrate drying ointment, it is standby both to have got Fructus Mume extract;
(3). take by weighing Herba Houttuyniae and pulverize, then with the petroleum ether soak degreasing of 6-8 times of Herba Houttuyniae weight, obtaining the Herba Houttuyniae sediment uses 6-10 times of 60-80% ethanol to soak extraction, 3-4 time continuously, each 3-5 hour, collect filtrate, reclaim ethanol, the concentrate drying ointment, it is standby both to have got Herba Houttuyniae extract;
(4). take by weighing Semen Ziziphi Spinosae extract, Fructus Mume extract and Herba Houttuyniae extract respectively according to weight proportion and pulverize, cross mix homogeneously behind the 80-100 mesh sieve, be dissolved in dehydrated alcohol by weight ratio, add the purified water dilution more by weight ratio, packing both must be treated the Chinese medicinal perfusion liquid finished product of mammitis of cow behind steam sterilization.
Advantage of the present invention and beneficial effect are:
1, the Chinese medicinal perfusion liquid of this treatment mammitis of cow adopts Fructus Mume extract, Semen Ziziphi Spinosae extract and Herba Houttuyniae as effective Chinese medicinal ingredients, has good heat-clearing and toxic substances removing, anti-inflammation, the analgesic activity of calming the nerves.As the natural Chinese medicines extract, do not have any poisonous and harmful substance simultaneously, can not produce toxic and side effects, more can not exert an influence health to animal body.
2, the Chinese medicinal perfusion liquid of this treatment mammitis of cow is introduced perfusion technique in into this pharmaceutical preparation cleverly, when expecting that dosing mode can't play, traditional companion does the time spent, this Chinese medicinal perfusion liquid can make the dispensing treatment more handy, save a large amount of manpower and materials, effective ingredient in the medicine is dissolved rapidly and uniformly, be convenient to domestic animal and absorb, improve bioavailability, can significantly improve the clinical efficacy of medicine.
3, onset speed of the present invention fast, have no side effect, drug residue free, easy to use, save aquaculture cost, simplify the operation, the bioavailability height is a kind of Chinese medicinal perfusion liquid that meets the treatment mammitis of cow of safe veterinary drug, guarantee animal-derived food safety requirements.
The specific embodiment
The present invention is described in further detail by following examples.Need to prove: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
A kind of Chinese medicinal perfusion liquid for the treatment of mammitis of cow, the component and the weight thereof of its Chinese medicine infusion liquid are respectively: Fructus Mume extract 1kg; Semen Ziziphi Spinosae extracts 1kg; Herba Houttuyniae extract 1kg; Dehydrated alcohol 5kg; Purified water 10kg.
A kind of preparation method for the treatment of the Chinese medicinal perfusion liquid of mammitis of cow, the step of its preparation method is as follows:
(1). take by weighing Semen Ziziphi Spinosae and pulverize, use the petroleum ether soak degreasing of 6 times of Semen Ziziphi Spinosae weight then, the Semen Ziziphi Spinosae sediment that obtains uses 6 times of weight 60% ethanol to soak extraction, continuous 3 times, each 3 hours, collect filtrate, reclaim ethanol, the concentrate drying ointment, it is standby both to have got Semen Ziziphi Spinosae extract;
(2). take by weighing Fructus Mume and pulverize, use the petroleum ether soak degreasing of 6 times of Fructus Mume weight then, obtain the Fructus Mume sediment and use 1 times of n-butyl alcohol to soak extraction, continuous 1 time, each 1 hour, collect filtrate, reclaim n-butyl alcohol, the concentrate drying ointment, it is standby both to have got Fructus Mume extract;
(3). take by weighing Herba Houttuyniae and pulverize,, obtain the Herba Houttuyniae sediment and use 6 times of 60% ethanol to soak extraction then with the petroleum ether soak degreasing of 6-8 times of Herba Houttuyniae weight, continuous 3 times, each 3 hours, collect filtrate, reclaim ethanol, the concentrate drying ointment, it is standby both to have got Herba Houttuyniae extract;
(4). take by weighing Semen Ziziphi Spinosae extract, Fructus Mume extract and Herba Houttuyniae extract respectively according to weight proportion and pulverize, cross mix homogeneously behind 80 mesh sieves, be dissolved in dehydrated alcohol by weight ratio, add the purified water dilution more by weight ratio, packing both must be treated the Chinese medicinal perfusion liquid finished product of mammitis of cow behind steam sterilization.
Embodiment 2
A kind of Chinese medicinal perfusion liquid for the treatment of mammitis of cow, the component and the weight thereof of its Chinese medicine infusion liquid are respectively: Fructus Mume extract 10kg; Semen Ziziphi Spinosae extracts 10kg; Herba Houttuyniae extract 10kg; Dehydrated alcohol 30kg; Purified water 50kg
A kind of preparation method for the treatment of the Chinese medicinal perfusion liquid of mammitis of cow, the step of its preparation method is as follows:
(1). take by weighing Semen Ziziphi Spinosae and pulverize, use the petroleum ether soak degreasing of 8 times of Semen Ziziphi Spinosae weight then, the Semen Ziziphi Spinosae sediment that obtains uses 10 times of weight 80% ethanol to soak extraction, continuous 4 times, each 5 hours, collect filtrate, reclaim ethanol, the concentrate drying ointment, it is standby both to have got Semen Ziziphi Spinosae extract;
(2). take by weighing Fructus Mume and pulverize, use the petroleum ether soak degreasing of 8 times of Fructus Mume weight then, obtain the Fructus Mume sediment and use 4 times of n-butyl alcohol to soak extraction, continuous 4 times, each 4 hours, collect filtrate, reclaim n-butyl alcohol, the concentrate drying ointment, it is standby both to have got Fructus Mume extract;
(3). take by weighing Herba Houttuyniae and pulverize, use the petroleum ether soak degreasing of 8 times of Herba Houttuyniae weight then, obtain the Herba Houttuyniae sediment and use 10 times of 80% ethanol to soak extraction, continuous 4 times, each 5 hours, collect filtrate, reclaim ethanol, the concentrate drying ointment, it is standby both to have got Herba Houttuyniae extract;
(4). take by weighing Semen Ziziphi Spinosae extract, Fructus Mume extract and Herba Houttuyniae extract respectively according to weight proportion and pulverize, cross mix homogeneously behind 100 mesh sieves, be dissolved in dehydrated alcohol by weight ratio, add the purified water dilution more by weight ratio, packing both must be treated the Chinese medicinal perfusion liquid finished product of mammitis of cow behind steam sterilization.
Embodiment 3
A kind of Chinese medicinal perfusion liquid for the treatment of mammitis of cow, the component and the weight thereof of its Chinese medicine infusion liquid are respectively: Fructus Mume extract 5kg; Semen Ziziphi Spinosae extracts 5kg; Herba Houttuyniae extract 5kg; Dehydrated alcohol 20kg; Purified water 25kg.
The step of its preparation method is with embodiment 1.
Embodiment 4
A kind of Chinese medicinal perfusion liquid for the treatment of mammitis of cow, the component and the weight thereof of its Chinese medicine infusion liquid are respectively: Fructus Mume extract 3kg; Semen Ziziphi Spinosae extracts 6kg; Herba Houttuyniae extract 6kg; Dehydrated alcohol 25kg; Purified water 30k
The step of its preparation method is with embodiment 2.
The clinical practice experiment
In order to verify that the present invention treats the therapeutic effect of the Chinese medicinal perfusion liquid of mammitis of cow to the mammitis of cow natural cases, we have carried out the mammitis of cow therapeutic test in Wuqing District milk cattle cultivating base, Tianjin.In the test, every group of filling agent is divided into different dosing dosage, carried out curative effect relatively with the routine medication of cattle farm mastitis, thereby estimated this filling agent at mammitis of cow therapeutic effect and optimum amount.
Material and method
1.1 experimental animal
Select 20 of mastitis morbidity milch cows, 4 every group.Milch cow is raised according to normal feeding and management program.
1.2 trial drug
The test infusion liquid is prepared by our company.
Swelling of the breast health injection: 20ml/ props up, Heilongjiang Province Beian Feilong Animal Drugs Factory, product batch number 080104
1.3 test method
Check breast and milk character and detecting when the mastitis case is mainly operated by milker cooperates the BMT method to detect simultaneously, by the veterinary case random packet treated then.
1.4 mastitis diagnostic criteria
Clinic mastitis is to be characteristics with the swelling to some extent of milk degeneration, breast tissue, warm and pain, possesses that following symptom or partial symptoms person are diagnosable to be clinic mastitis: breast volume increase, heating, quality hardening; Skin of breast is rubescent, and palpation has pain; Each breast district is not of uniform size, the enlargement of breast superior gluteal lymph node; Milk variable color, thickness, floccule, ziega, clot etc. to occur unusual.
1.5 grouping medication
Each case is included into trial drug group of the present invention at random respectively, and it is as follows that its dosage difference is divided into A, B, four groups of C, D and swelling of the breast health injection matched group:
A: through the Ipsilateral nipple in mammary gland is injected in newborn pond, each 10ml, every day 1 time, 5 days courses of treatment.
B: through the Ipsilateral nipple in mammary gland is injected in newborn pond, each 20ml, every day 1 time, 5 days courses of treatment.
C: through the Ipsilateral nipple in mammary gland is injected in newborn pond, each 30ml, every day 1 time, 5 days courses of treatment.
D: through the Ipsilateral nipple in mammary gland is injected in newborn pond, each 40ml, every day 1 time, 5 days courses of treatment.
Swelling of the breast health injection matched group: through the Ipsilateral nipple in mammary gland is injected in newborn pond, each 150ml, every day 1 time, 5 days courses of treatment.
Each is organized and all gently pinches the nipple mouth after medicine injects the nipple mouth with milch cow lactogenesis pin with medicine, leniently massages breast, and medicine is pushed to mammary gland top.
1.6 therapeutic effect decision method
Cure: clinical symptom disappearance, milk directly perceived is no abnormal, and milk yield recovers substantially, and BMT method testing result is lower than " ++ " for curing.
Effectively: clinical symptom relief or disappearance, a small amount of floccule is arranged in the milk, but the milk color and luster is no abnormal, it is normal that output fails to recover, and the BMT testing result still is higher than " ++ ".
Invalid: each clinical symptoms in the criterion does not alleviate or aggravates.
1.7 statistical analysis
Through the X2 check, A group cure rate and total effective rate significantly are lower than other each group (P＜0.05) other each group differences not remarkable (P＞0.05).
2 result of the tests
2.1 filling agent treatment back is to the influence of fertility performance
The results are shown in Table 1. mastitis appears and after, give the filling agent morbidity mammitis of cow clinical symptom relief of various dose respectively, the level of giving milk is recovered, breast inflammation is alleviated to some extent.But A group therapeutic effect is not obvious, still occur a spot of blood in the milk, and the milk viscosity increases; Swelling of the breast health treatment of control group rear udder attachment inflammation is alleviated, but milk yield descends.
Table 1 observation of curative effect
2.2 the influence that the treatment back is alleviated mastitis
The results are shown in Table 2.
Table 2
3 interpretations of result
Analyze from clinical symptoms, the treatment of giving milk, the alleviation of mastitis inflammation, four aspects of cure rate, the therapeutic effect that C, D are two groups is apparently higher than the other treatment group.Matched group has certain therapeutic effect, but the treatment back milch cow restore cycle is longer, and economic loss is bigger.
4 conclusions
Infusion liquid of the present invention is by each 30ml, every day 1 time, clinical type mastitis treated in continuous 5 days, to mammitis of cow therapeutic effect the best.
Claims (2)
1. Chinese medicinal perfusion liquid for the treatment of mammitis of cow, it is characterized in that: the component of this Chinese medicinal perfusion liquid and ratio of weight and number thereof are:
Fructus Mume extract 1-10 part;
Semen Ziziphi Spinosae extracts 1-10 part;
Herba Houttuyniae extract 1-10 part;
Dehydrated alcohol 5-30 part;
Purified water 10-50 part.
2. the preparation method of the Chinese medicinal perfusion liquid of a treatment mammitis of cow as claimed in claim 1, it is characterized in that: the step of this preparation method is as follows:
(1). take by weighing Semen Ziziphi Spinosae and pulverize, then with the petroleum ether soak degreasing of 6-8 times of Semen Ziziphi Spinosae weight, the Semen Ziziphi Spinosae sediment that obtains uses 6-10 times of weight 60-80% ethanol to soak extraction, 3-4 time continuously, each 3-5 hour, collect filtrate, reclaim ethanol, the concentrate drying ointment, it is standby both to have got Semen Ziziphi Spinosae extract;
(2). take by weighing Fructus Mume and pulverize,, obtain the Fructus Mume sediment and use 1-4 times of n-butyl alcohol to soak extraction then with the petroleum ether soak degreasing of 6-8 times of Fructus Mume weight, 1-4 time continuously, each 1-4 hour, collect filtrate, reclaim n-butyl alcohol, the concentrate drying ointment, it is standby both to have got Fructus Mume extract;
(3). take by weighing Herba Houttuyniae and pulverize, then with the petroleum ether soak degreasing of 6-8 times of Herba Houttuyniae weight, obtaining the Herba Houttuyniae sediment uses 6-10 times of 60-80% ethanol to soak extraction, 3-4 time continuously, each 3-5 hour, collect filtrate, reclaim ethanol, the concentrate drying ointment, it is standby both to have got Herba Houttuyniae extract;
(4). take by weighing Semen Ziziphi Spinosae extract, Fructus Mume extract and Herba Houttuyniae extract respectively according to weight proportion and pulverize, cross mix homogeneously behind the 80-100 mesh sieve, be dissolved in dehydrated alcohol by weight ratio, add the purified water dilution more by weight ratio, packing both must be treated the Chinese medicinal perfusion liquid finished product of mammitis of cow behind steam sterilization.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110051427A CN102119977B (en) | 2011-03-03 | 2011-03-03 | Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof |
| AU2011101378A AU2011101378A4 (en) | 2011-03-03 | 2011-04-01 | Traditional Chinese medicine perfusate for the treatment of dairy cow mastitis and a preparation method thereof |
| PCT/CN2011/072369 WO2012116507A1 (en) | 2011-03-03 | 2011-04-01 | Traditional chinese medicine perfusate for treating cow mastitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110051427A CN102119977B (en) | 2011-03-03 | 2011-03-03 | Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN102119977A true CN102119977A (en) | 2011-07-13 |
| CN102119977B CN102119977B (en) | 2011-12-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201110051427A Expired - Fee Related CN102119977B (en) | 2011-03-03 | 2011-03-03 | Chinese medicinal infusion solution for treating bovine mastitis and preparation method thereof |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN102119977B (en) |
| AU (1) | AU2011101378A4 (en) |
| WO (1) | WO2012116507A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102580068A (en) * | 2012-03-20 | 2012-07-18 | 宁夏职业技术学院 | Compound perfusate for treating mammitis of dairy cattle and preparation method thereof |
| CN103007022A (en) * | 2012-11-22 | 2013-04-03 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating mastitis of dairy cows and preparation method of composition |
| CN103263523A (en) * | 2013-05-31 | 2013-08-28 | 挑战（天津）动物药业有限公司 | Breast perfusion agent for preventing and treating mastitis and preparation method of breast perfusion agent |
| CN105641102A (en) * | 2014-11-19 | 2016-06-08 | 天津嘉创生物科技有限公司 | An oral liquid for treating chicken respiratory tract diseases and a preparing method thereof |
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2011
- 2011-03-03 CN CN201110051427A patent/CN102119977B/en not_active Expired - Fee Related
- 2011-04-01 AU AU2011101378A patent/AU2011101378A4/en not_active Ceased
- 2011-04-01 WO PCT/CN2011/072369 patent/WO2012116507A1/en active Application Filing
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| CN1751596A (en) * | 2004-09-24 | 2006-03-29 | 江西本草天工科技有限责任公司 | Health-care food and its soft capsule for improving immunity of anti alimentary canal infection, and its prepn. method |
| CN101596246A (en) * | 2009-07-02 | 2009-12-09 | 北京中农普康生物科技有限公司 | Fructus Mume extract and wild jujube seed extractive compound preparation and its production and application |
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Cited By (7)
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|---|---|---|---|---|
| CN102580068A (en) * | 2012-03-20 | 2012-07-18 | 宁夏职业技术学院 | Compound perfusate for treating mammitis of dairy cattle and preparation method thereof |
| CN102580068B (en) * | 2012-03-20 | 2014-02-12 | 宁夏职业技术学院 | Compound perfusate for treating mammitis of dairy cattle and preparation method thereof |
| CN103007022A (en) * | 2012-11-22 | 2013-04-03 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating mastitis of dairy cows and preparation method of composition |
| CN103007022B (en) * | 2012-11-22 | 2014-12-31 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating mastitis of dairy cows and preparation method of composition |
| CN103263523A (en) * | 2013-05-31 | 2013-08-28 | 挑战（天津）动物药业有限公司 | Breast perfusion agent for preventing and treating mastitis and preparation method of breast perfusion agent |
| CN103263523B (en) * | 2013-05-31 | 2015-10-28 | 天津市中升挑战生物科技有限公司 | A kind of for breast perfusion preparation preventing and treating mastitis and preparation method thereof |
| CN105641102A (en) * | 2014-11-19 | 2016-06-08 | 天津嘉创生物科技有限公司 | An oral liquid for treating chicken respiratory tract diseases and a preparing method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102119977B (en) | 2011-12-28 |
| WO2012116507A1 (en) | 2012-09-07 |
| AU2011101378A4 (en) | 2011-11-24 |
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