CN100471510C - Combination of lmedication for treatig mastitis of cow and preparation method - Google Patents
Combination of lmedication for treatig mastitis of cow and preparation method Download PDFInfo
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- CN100471510C CN100471510C CNB2004100816251A CN200410081625A CN100471510C CN 100471510 C CN100471510 C CN 100471510C CN B2004100816251 A CNB2004100816251 A CN B2004100816251A CN 200410081625 A CN200410081625 A CN 200410081625A CN 100471510 C CN100471510 C CN 100471510C
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Abstract
A Chinese medicine for treating the mammitis of milk cow is prepared from 7 Chinese-medicinal materials including peach kernel, safflower, Chinese angelica root, Chuan-xiong rhizome, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of mammitis of cow, specifically, it is to be the veterinary medicine that feedstock production forms by Chinese crude drug, belongs to field of veterinary.
Background technology
Mammitis of cow is one of milch cow commonly encountered diseases, and sickness rate accounts for 20%～60% of cow in milk.Since this sick very difficult control, difficult again thoroughly elimination, and have certain popularity, this characteristic of disease complexity is various pathogens mixed infection, and the milk industry is produced harm seriously.The treatment mammitis of cow is always with antibiotic such as penicillin, streptomycin, soluble sulphathiazoles, and must be heavy dose of, life-time service or use these antibiotic repeatedly, certain effect is just arranged, these antibiotic very easily form drug resistance, thereby cause curative effect decline; Also might cause antibiotic residual in milk, cause that newborn matter product pollute, very harmful to health, next is heavy dose of life-time service antibiotic, though pathogenic bacteria is had inhibition or killing action, also can influence simultaneously the normal breeding of probiotics in the milch cow body, severe patient will cause dysbacteriosis in the milch cow body.The microbial ecological balance is destroyed, and hides and takes advantage of the occasion to breed in a large number in the intravital harmful pathogenic bacterium of milch cow, and then cause autogenous infection.Use antibiotic in addition, the treatment mammitis of cow is a kind of high cost in wide farmers.In raising peasant household scattered, be difficult at present promote, in the cattle farm or peasant household, also will consider the food sanitation safe of milch cow goods, therefore, should not promote antibiotics and be used for the treatment of mammitis of cow.
SIWU TANG (coming from " formulary of peaceful benevolent dispensary ") commonly used is made up of Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata four flavor Chinese medicines, is that to transfer blood to enrich blood be the prescription of main function, is described as " total sides of all disorders of blood ", " the special agent of Liver Channel accent blood ".Though the treatment mammitis of cow has certain curative effect, but cure rate is extremely low, only be 45-60%, Fa Bing probability is very big repeatedly, about 20-28% is though SIWU TANG is the classical side's medicine in the human medicine, because the difference of the physiological make-up of animals and human beings body, the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of Animal diseases is different with the human disease, to the effective medicine of people's medication and do not mean that animal tangible curative effect is just arranged on one's body.
Summary of the invention
Technical scheme of the present invention has provided a kind of pharmaceutical composition for the treatment of mammitis of cow, and another technical scheme of the present invention has provided this preparation of drug combination method.
The invention provides a kind of pharmaceutical composition for the treatment of mammitis of cow, it is by containing the preparation that following weight proportion raw material system respectively forms:
Semen Persicae 20-100 part, Flos Carthami 3-20 part, Radix Angelicae Sinensis 20-100 part, Rhizoma Chuanxiong 20-100 part, Radix Bupleuri 10-90 part, Herba Leonuri 20-200 part, Medulla Tetrapanacis 10-90 part.
Further, it is the preparation that is prepared from by the following weight proportion raw material:
Semen Persicae 20-100 part, Flos Carthami 3-20 part, Radix Angelicae Sinensis 20-100 part, Rhizoma Chuanxiong 20-100 part, Radix Bupleuri 10-90 part, Herba Leonuri 20-200 part, Medulla Tetrapanacis 10-90 part.
Further, it is the preparation that is prepared from by the following weight proportion raw material:
70 parts in Semen Persicae, 15 parts on Flos Carthami, 70 parts of Radix Angelicae Sinensis, 70 parts of Rhizoma Chuanxiongs, 60 parts of Radix Bupleuri, 100 parts of Herba Leonuris, 50 parts of Medulla Tetrapanaciss.
Pharmaceutical composition provided by the invention is that the water extract by Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Bupleuri, Herba Leonuri, Medulla Tetrapanacis is that active component mixes, and adds the preparation that adjuvant commonly used in the pharmacy or complementary composition are prepared from.
Wherein, described preparation is: decoction, tablet, powder, pill, granule, capsule.
The present invention also provides a kind of method for preparing this pharmaceutical composition, and it comprises the steps:
A, take by weighing the following weight proportion raw material:
Semen Persicae 20-100 part, Flos Carthami 3-20 part, Radix Angelicae Sinensis 20-100 part, Rhizoma Chuanxiong 20-100 part, Radix Bupleuri 10-90 part, Herba Leonuri 20-200 part, Medulla Tetrapanacis 10-90g;
B, with a step claim each materials of weight proportions through water extraction, concentrate after, add acceptable accessories or complementary composition, be prepared into preparation pharmaceutically commonly used.
The consumption of drug component of the present invention is to sum up by inventor's long-felt to draw, and raw material is made up of Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Bupleuri, Herba Leonuri, Medulla Tetrapanacis, wherein Semen Persicae, Flos Carthami, Radix Angelicae Sinensis and Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling.The merit of Radix Bupleuri ascending up spleen-Qi and Yang, detoxifcation, reducing swelling and alleviating pain, the detoxifcation of stimulating the menstrual flow of Herba Leonuri, Medulla Tetrapanacis.Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Herba Leonuri have stronger bactericidal effect to staphylococcus aureus; Rhizoma Chuanxiong, Radix Angelicae Sinensis, Flos Carthami streptococcus, bacillus pyocyaneus are quite strong, and Herba Leonuri also has the effect of streptococcus; Radix Angelicae Sinensis Chinese People's Anti-Japanese Military and Political College enterobacteria is apparent especially, and Rhizoma Chuanxiong can not only Chinese People's Anti-Japanese Military and Political College enterobacteria, and can do Bacillus proteus.Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong energy blood vessel dilating improve blood circulation, still can ease pain; Radix Angelicae Sinensis, Radix Bupleuri can also ooze out by anti-inflammatory, and the compatibility Semen Persicae has the dissipation of promotion effect to inflammatory hyperplasia.The analgesic function of Radix Bupleuri is also shown.Radix Angelicae Sinensis has the effect of hemopoietic, and Medulla Tetrapanacis can lactogenic.
Medicine of the present invention is used for the treatment of mammitis of cow, and is safe, effective, economical, and medicine do not have influence to the milk quality, can increase milk yield, and production technology is simple, and is easy to use.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1 medicine of the present invention
Semen Persicae 70kg, Flos Carthami 15kg, Radix Angelicae Sinensis 70kg, Rhizoma Chuanxiong 70kg, Radix Bupleuri 60kg, Herba Leonuri 100kg, Medulla Tetrapanacis 90kg.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, with ordinary water medical material is soaked (liquid level exceeds medicine and is as the criterion) after 1-2 hour, will decoct extracting juice (be heated to the medicinal liquid boiling, continue to decoct 20 minutes again, filter) then; Medicine is decocted three times as stated above.Merging filtrate; Filtrate is concentrated into 1230ml, (make that crude drug content reaches 0.5g/ml in the medicinal liquid, every 100ml concentrated solution adds the 0.1g sodium benzoate, prevents that medicine is putrid and deteriorated, with the pH to 4.5 of 0.1 molar concentration hydrochloric acid accent medicinal liquid, mixing).Be sub-packed in the 500ml bottle, sealing, standby.(this medicinal liquid can be guaranteed the quality under normal condition 2 years).
The preparation of embodiment 2 medicines of the present invention
A, take by weighing the raw material of following weight: Semen Persicae 20kg, Flos Carthami 3kg, Radix Angelicae Sinensis 20kg, Rhizoma Chuanxiong 20kg, Radix Bupleuri 10kg, Herba Leonuri 20kg, Medulla Tetrapanacis 10kg;
B, the method preparation of pressing embodiment 1.
The preparation of embodiment 3 medicines of the present invention
A, take by weighing the raw material of following weight: Semen Persicae 100kg, Flos Carthami 20kg, Radix Angelicae Sinensis 100kg, Rhizoma Chuanxiong 100kg, Radix Bupleuri 90kg, Herba Leonuri 200kg, Medulla Tetrapanacis 90kg;
B, the method preparation of pressing embodiment 1.
The preparation of embodiment 4 medicines of the present invention
Raw material: Semen Persicae 60kg, Flos Carthami 10kg, Radix Angelicae Sinensis 80kg, Rhizoma Chuanxiong 75kg, Radix Bupleuri 50kg, Herba Leonuri 120kg, Medulla Tetrapanacis 30kg, Herba Schizonepetae 59kg, Rhizoma Atractylodis Macrocephalae 40kg, Fructus Liquidambaris 60kg.
With ordinary water above-mentioned medical material immersion after 1-2 hour (liquid level exceeds medicine and is as the criterion), will be decocted extracting juice (be heated to the medicinal liquid boiling, continue to decoct 20 minutes again, filter) then; Medicine is decocted three times as stated above.Merging filtrate; Filtrate is concentrated into 1230ml, (make that crude drug content reaches 0.5kg/ml in the medicinal liquid, every 100ml concentrated solution adds the 0.1kg sodium benzoate, prevents that medicine is putrid and deteriorated, with the pH to 4.5 of 0.1 molar concentration hydrochloric acid accent medicinal liquid, mixing).Be sub-packed among the 500ml, sealing, standby.
Below further set forth the beneficial effect of medicine of the present invention by testing example, these experimental examples have comprised that the pharmacodynamics test of medicine of the present invention and clinical observation on the therapeutic effect test.
The safety experiment of experimental example 1 medicine of the present invention
Select 50 health, Kunming kind white mice.After under identical conditions, feeding 7, be divided into 5 groups at random, every group 10, with ready prepd medicine concentrated solution of the present invention or dilution press crude drug content 2.5kg/ only, 25kg/ only, 250kg/ only, 2500kg/ only, 25000kg/, respectively each group white mice is carried out the drug toxicology experiment, medication in continuous three days, the death condition of observing white mice.Its death condition is respectively 0,2,3,7 and 10.Obtain big characteristics.Medicine median lethal dose(LD 50) of the present invention (LD50) is 5005kg/, can judge that thus medicine of the present invention is used for the treatment of the milk cattle disease, and toxic and side effects is little, and safety coefficient is big, more can guarantee the safety of milk simultaneously.
The drug effect of experimental example 2 Drug therapy dairy cow breast inflammation of the present invention
The experimental control medicine:
Select penicillin sodium for use, animal drug factory of Soviet Union produces lot number: 971024, and specification: 800,000 units/; Streptomycin, animal health Pharmaceutical Co., Ltd in West China, Sichuan produces, lot number: 970416, specification 1,000,000 units/.
Select 3-5 year in Sichuan Institute of Animal Husbandry and Veterinary Medicine practice pasture, the cattle farm, Rongchang County, 100 of the Chinese Fresians of farrowing 1-2 tire are the test milch cow.In the selected milch cow earlier with the hospital physics inspection, that breast has is red, swollen, hot, bitterly and the milk amount less or do not have milk the person is a clinic mastitis; The latent mammitis clinical manifestation is not obvious, but carry out the inspection of milk basicity,, drip in vitro or in the milk on the slide with 0.5% bromine coal tar oleyl alcohol or bromothymol blue indicator number droplet, or on paper that dips in indicator or gauze, dripping several milk, purple or purple green appears; If no above-mentioned detection symptom, then this milch cow is negative.100 cow heads are divided into invention medicine group (50), and every gavages with medicine medicine concentrated solution 500ml of the present invention at every turn; Every of Western medicine group (50) is each with penicillin sodium 8,000,000 units and streptomycin 1,000 ten thousand units, mix with distilled water diluting, an intramuscular injection, respectively be administered once in 8 and following 3 of each mornings, logotype three days, after stopping administration, the 7th day and three month by the method for above-mentioned diagnosis mastitis to test Niu Jinhang check.
Result of the test: medication is after three days, 48 recoveries from illness of medicine group of the present invention.34 recoveries from illness of Western medicine group.After the medication seven days, medicine group recovery from illness of the present invention, cure rate 100%, 46 recoveries from illness of Western medicine group, cure rate reaches 92%.45 of medicine groups wherein of the present invention all have lactation amount to increase, and account for 90%, and normal amount was many before its milk amount was more ill, and increase 1kg average every day, and after three months, the state of an illness of medicine group of the present invention does not descend after its lactation amount increase not repeatedly yet; The Western medicine group has 5 characteristic of disease recurrences, and relapse rate accounts for 10%, and milk yield descends significantly and reaches 20-30%.
Yak milch cow and same method such as Russia Thomas township, Buddhist nun Xia Zhen in state, Ganzi Shiqu County squadron are treated 2400 of yak mammitis of cow, medicine group of the present invention (1200) cure rate reaches 100%, no case was recurrence, milk yield increases and reaches 20%, 1098 of Western medicine group (1200) recoveries from illness, cure rate 91.5% recurs 132, accounts for 11%.
Above-mentioned result of the test shows that medicine of the present invention has very definite and significant clinical efficacy, treatment milch cow 2450 examples, cure rate reaches 100%, no case was recurrence, do not see drug resistance and toxicity, pathogenic bacterium staphylococcus aureus, streptococcus, the bacillus pyocyaneus that causes mammitis of cow had suppress and killing action to have the effect of Chinese People's Anti-Japanese Military and Political College enterobacteria and Bacillus proteus simultaneously, to the prevention of mammitis of cow, increase breast and have more value, be very favourable to the development dairy.
The economic benefit of experimental example 3 medicines of the present invention and social benefit analysis
One cow head needs medicine concentrated solution 3000ml of the present invention, just can cure mastitis, produces this concentrated solution 3000ml and needs 10.8 yuan of market costs; Treat a cow head and need use penicillin 4,800 ten thousand units and streptomycin 6,000 ten thousand units, need be with regard to the existing market valency with 57 yuan.Therefore, medicine of the present invention is controlled mammitis of cow and is controlled 46.2 yuan of costs, economic science than the western medicine saving.
Drug therapy mammitis of cow of the present invention does not have influence to the milk quality, can effectively guarantee the milk safety; And can increase milk production, production technology is simple, and is easy to use, with low cost.
Claims (8)
1, a kind of pharmaceutical composition for the treatment of mammitis of cow is characterized in that: it is the preparation that is prepared from by the following weight proportion raw material:
Semen Persicae 20-100 part, Flos Carthami 3-20 part, Radix Angelicae Sinensis 20-100 part, Rhizoma Chuanxiong 20-100 part, Radix Bupleuri 10-90 part, Herba Leonuri 20-200 part, Medulla Tetrapanacis 10-90 part.
2, the pharmaceutical composition of treatment mammitis of cow according to claim 1 is characterized in that: it is the preparation that is prepared from by the following weight proportion raw material:
70 parts in Semen Persicae, 15 parts on Flos Carthami, 70 parts of Radix Angelicae Sinensis, 70 parts of Rhizoma Chuanxiongs, 60 parts of Radix Bupleuri, 100 parts of Herba Leonuris, 50 parts of Medulla Tetrapanaciss.
3, the pharmaceutical composition of treatment mammitis of cow according to claim 1 and 2, it is characterized in that: it is that water extract by Semen Persicae, Flos Carthami, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Bupleuri, Herba Leonuri, Medulla Tetrapanacis is that active component mixes, and adds the preparation that adjuvant commonly used in the pharmacy or complementary composition are prepared from.
4, the pharmaceutical composition of treatment mammitis of cow according to claim 3 is characterized in that: described preparation is: decoction, tablet, powder, pill, granule or capsule.
5, a kind of method for preparing the pharmaceutical composition of the described treatment mammitis of cow of claim 1, it comprises the steps:
A, take by weighing the following weight proportion raw material:
Semen Persicae 20-100 part, Flos Carthami 3-20 part, Radix Angelicae Sinensis 20-100 part, Rhizoma Chuanxiong 20-100 part, Radix Bupleuri 10-90 part, Herba Leonuri 20-200 part, Medulla Tetrapanacis 10-90 part;
B, with a step claim each materials of weight proportions through water extraction, concentrate after, add acceptable accessories or complementary composition, be prepared into preparation pharmaceutically commonly used.
6, the purposes of the described pharmaceutical composition of claim 1 in the medicine of preparation treatment mammitis of cow.
Priority Applications (1)
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| CNB2004100816251A CN100471510C (en) | 2004-12-29 | 2004-12-29 | Combination of lmedication for treatig mastitis of cow and preparation method |
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| CNB2004100816251A CN100471510C (en) | 2004-12-29 | 2004-12-29 | Combination of lmedication for treatig mastitis of cow and preparation method |
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| CN100471510C true CN100471510C (en) | 2009-03-25 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101134080B (en) * | 2006-08-30 | 2011-09-07 | 瑞普（天津）生物药业有限公司 | Compound traditional Chinese powder medicine for treating acute mastitis for cows |
| CN101507764B (en) * | 2009-03-28 | 2011-05-18 | 山西芮城亚宝兽药有限公司 | Chinese herbal medicine spraying agent for treating milking-stock mastitis and preparation method thereof |
| CN102188581B (en) * | 2011-05-11 | 2012-07-25 | 张亚东 | Traditional Chinese medicinal composition for treating bovine mastitis |
| CN103169817A (en) * | 2012-06-12 | 2013-06-26 | 北京伟嘉人生物技术有限公司 | External medicine for treating mastitis in dairy cattle |
| CN102772520B (en) * | 2012-08-16 | 2014-06-18 | 高利 | Traditional Chinese medicine composition for preventing or treating bovine mastitis and preparation method of composition |
| CN104435391A (en) * | 2014-12-29 | 2015-03-25 | 河南天纳图生物科技有限公司 | Fermentation traditional Chinese medicine for activating blood and increasing milk for livestock and preparation method thereof |
| CN115944675A (en) * | 2023-02-14 | 2023-04-11 | 长沙县自成养殖科技有限公司 | Chinese herbal medicine composition for promoting cow postpartum lochia discharge and lactation promotion and feeding method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491675A (en) * | 2002-10-22 | 2004-04-28 | 赵志敏 | Medicine for treating cow mammitis |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491675A (en) * | 2002-10-22 | 2004-04-28 | 赵志敏 | Medicine for treating cow mammitis |
Non-Patent Citations (4)
| Title |
|---|
| 中西医结合治疗母牛缺乳效果好. 张虎社.中国草食动物，第24卷第1期. 2004 |
| 中西医结合治疗母牛缺乳效果好. 张虎社.中国草食动物，第24卷第1期. 2004 * |
| 桃红散防治奶牛乳房炎效果试验. 贺永建，林义明.四川畜牧兽医学院学报，第13卷第2期. 1999 |
| 桃红散防治奶牛乳房炎效果试验. 贺永建，林义明.四川畜牧兽医学院学报，第13卷第2期. 1999 * |
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