CN104367746A - Compound traditional Chinese medicine perfusion agent used for treating endometritis of dairy cow and preparation method of compound traditional Chinese medicine perfusion agent - Google Patents

Compound traditional Chinese medicine perfusion agent used for treating endometritis of dairy cow and preparation method of compound traditional Chinese medicine perfusion agent Download PDF

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CN104367746A
CN104367746A CN201410608448.1A CN201410608448A CN104367746A CN 104367746 A CN104367746 A CN 104367746A CN 201410608448 A CN201410608448 A CN 201410608448A CN 104367746 A CN104367746 A CN 104367746A
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chinese medicine
traditional chinese
radix
perfusion agent
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王连民
郭群
刘睿芬
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Tianjin Shengji Group Co Ltd
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Tianjin Shengji Group Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
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    • A61K9/00Medicinal preparations characterised by special physical form
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    • A61K9/0041Mammary glands, e.g. breasts, udder; Intramammary administration
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a compound traditional Chinese medicine perfusion agent used for treating endometritis of a dairy cow. The compound traditional Chinese medicine perfusion agent used for treating the endometritis of the dairy cow is prepared from the following medicinal materials: 5-9 parts of Chinese angelica, 5-8 parts of radix paeoniae alba, 4-7 parts of szechwan Chinaberry fruit, 4-7 parts of motherwort, 3-6 parts of peach kernel, 3-6 parts of ligusticum wallichii, 2-5 parts of rhizoma cyperi, 2-5 parts of cortex lycii radicis, 1-3 parts of radix bupleuri and 1-3 parts of mint. The invention provides a traditional Chinese medicine veterinary drug perfusion agent mainly used for preventing and treating the endometritis of the dairy cow and has the characteristics of quick effect, real curative effect, no drug residue and no need for withdrawal time.

Description

A kind of herbal mixture filling agent being used for the treatment of cow endometritis and preparation method thereof
Technical field
The present invention relates to veterinary drug technical field, particularly relate to a kind of herbal mixture filling agent being used for the treatment of cow endometritis and preparation method thereof.
Background technology
Cow endometritis is one of the most common disease of milch cow, can be divided into acute, chronic and a few class of recessiveness according to clinical symptoms.It is reported, 40% of childbirth number of cows is accounted in national milch cow Endometrial inflammation, if generally mostly be to treat not in time because bacteriological infection Uterus wall causes, inflammation just easily diffuses to form myometritis parametritis etc., and transfer chronic inflammatory disease to, become the one of the main reasons that milch cow Repeat breeding breeding potential is low.This disease badly influences milch cow conception rate and development of dairy industry, adds cow culling rate, brings about great losses to aquaculture.
In clinical position, the treatment of cow uteri inflammation, generally adopts antibiotic etc, but widely uses along with antibiotic is a large amount of for a long time, creates the problem of antibiotic remains in bacterial drug resistance and milk.Along with people's improving constantly and the national requirement stricter to quality of dairy products food safety requirements, the antibiotic of clinical conventional control mastitis will be limited the use of gradually owing to there is drug residue.And Chinese medicine has safe, efficient and not easily produces drug resistance, in recent years, be more and more subject to people's attention.
Summary of the invention
The object of the invention is the technological deficiency for existing in prior art, and a kind of herbal mixture filling agent being used for the treatment of cow endometritis and preparation method thereof is provided.
The technical scheme adopted for realizing object of the present invention is: a kind of herbal mixture filling agent being used for the treatment of cow endometritis, it is characterized in that, with weight parts, being made up of following medicinal materials: Radix Angelicae Sinensis 5 ~ 9 parts, the Radix Paeoniae Alba 5 ~ 8 parts, Fructus Toosendan 4 ~ 7 parts, Herba Leonuri 4 ~ 7 parts, 3 ~ 6 parts, Semen Persicae, Rhizoma Chuanxiong 3 ~ 6 parts, Rhizoma Cyperi 2 ~ 5 parts, Cortex Lycii 2 ~ 5 parts, Radix Bupleuri 1 ~ 3 part and Herba Menthae 1 ~ 3 part.
Preferably, above-mentioned traditional Chinese medicine perfusion agent, with weight parts, is made up of following medicinal materials: Radix Angelicae Sinensis 7 parts, the Radix Paeoniae Alba 7 parts, Fructus Toosendan 7 parts, Herba Leonuri 7 parts, 3 parts, Semen Persicae, Rhizoma Chuanxiong 3 parts, Rhizoma Cyperi 2 parts, Cortex Lycii 2 parts, Radix Bupleuri 1 part and Herba Menthae 1 part.
Be used for the treatment of a preparation method for the herbal mixture filling agent of cow endometritis, it is characterized in that comprising the following steps:
(1) following medicinal materials is taken by weight: Radix Angelicae Sinensis 5 ~ 9 parts, the Radix Paeoniae Alba 5 ~ 8 parts, Fructus Toosendan 4 ~ 7 parts, Herba Leonuri 4 ~ 7 parts, 3 ~ 6 parts, Semen Persicae, Rhizoma Chuanxiong 3 ~ 6 parts, Rhizoma Cyperi 2 ~ 5 parts, Cortex Lycii 2 ~ 5 parts, Radix Bupleuri 1 ~ 3 part and Herba Menthae 1 ~ 3 part;
(2) in raw material components, add whole medical material 10 times of water gagings, decoct 2 times, be respectively 2 hours and 1.5 hours, merge decoction liquor, filter, filtrate is concentrated in right amount, adds ethanol and makes alcohol content be 75%, leaves standstill, filter, filtrate recycling ethanol, add water standardize solution, adds the sodium benzoate of 3 ‰;
(3) bottle, sealing, sterilizing.
Described Chinese medicinal material all meets " Chinese veterinary pharmacopoeia " version two ministerial standard in 2010.
Chinese herbal medicine belongs to natural product, containing multiple biological effective components, there is antibacterial, antiinflammatory, not easily produce that bacterial drug resistance, internal metabolism are very fast, high-efficiency low-toxicity, the feature such as noresidue or low-residual, generally do not need the off-drug period after the treatment, alternative chemical synthetic drug, both can bacteriostasis and sterilization, strengthen the immunologic function of animal body, can be used as again the metabolism that Specialty bio active additive regulates body, promote the absorption of nutrient substance.Composition principle of the present invention is: Chinese angelica blood supplementing regulating menstruation in side, promoting blood circulation and stopping pain; The Radix Paeoniae Alba is nourished blood yin fluid astringing, easing the affected liver to relieve pain, suppressing liver-YANG; Fructus Toosendan promoting the circulation of QI to relieve pain, parasite killing; Herba Leonuri promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing; Semen Persicae blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma; Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping; Rhizoma Cyperi dispersing the stagnated live-QI to relieve the stagnation of QI, menstruction regulating and pain relieving, regulates the flow of vital energy in adjusting; Cortex Lycii removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing; Radix Bupleuri induces sweat and brings down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy; Herba Menthae dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.All medicines share, and play heat-clearing and toxic substances removing altogether, pain of enriching blood, blood circulation promoting and blood stasis dispelling, effect of anti-inflammation.
Beneficial effect of the present invention: for milk cow production provides a kind of being mainly used in prevent and treat the herbal medicine filling agent of cow endometritis, have instant effect, curative effect really, no drug residue, do not need the feature of off-drug period.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Embodiment 1
Be used for the treatment of a herbal mixture filling agent for cow endometritis, be made up of following raw materials according component: Radix Angelicae Sinensis 50g, Radix Paeoniae Alba 50g, Fructus Toosendan 40g, Herba Leonuri 40g, Semen Persicae 60g, Rhizoma Chuanxiong 40g, Rhizoma Cyperi 30g, Cortex Lycii 30g, Radix Bupleuri 20g, Herba Menthae 20g.
Radix Angelicae Sinensis 70g, Radix Paeoniae Alba 70g, Fructus Toosendan 70g, Herba Leonuri 70g, Semen Persicae 30g, Rhizoma Chuanxiong 30g, Rhizoma Cyperi 20g, Cortex Lycii 20g, Radix Bupleuri 10g, Herba Menthae 10g.
The above-mentioned preparation method being used for the treatment of the herbal mixture filling agent of cow endometritis, carries out as follows: in raw material components, add whole medical material 10 times of water gagings, decocts 2 times, be respectively 2 hours, 1.5 hours, merge decoction liquor, filter, filtrate is concentrated in right amount, adds ethanol and makes alcohol content be 75%, leaves standstill, filter, filtrate recycling ethanol, add water standardize solution, adds the sodium benzoate of 3 ‰.Bottling, sealing, sterilizing.
Embodiment 2
Be used for the treatment of a herbal mixture filling agent for cow endometritis, be made up of following raw materials according component: Radix Angelicae Sinensis 90g, Radix Paeoniae Alba 80g, Fructus Toosendan 60g, Herba Leonuri 60g, Semen Persicae 50g, Rhizoma Chuanxiong 60g, Rhizoma Cyperi 50g, Cortex Lycii 50g, Radix Bupleuri 30g, Herba Menthae 30g.
Above-mentioned herbal mixture filling agent its preparation method, is undertaken by embodiment 1.
Embodiment 3
Be used for the treatment of a herbal mixture filling agent for cow endometritis, be made up of following raw materials according component: Radix Angelicae Sinensis 5 ~ 9 parts, the Radix Paeoniae Alba 5 ~ 8 parts, Fructus Toosendan 4 ~ 7 parts, Herba Leonuri 4 ~ 7 parts, 3 ~ 6 parts, Semen Persicae, Rhizoma Chuanxiong 3 ~ 6 parts, Rhizoma Cyperi 2 ~ 5 parts, Cortex Lycii 2 ~ 5 parts, Radix Bupleuri 1 ~ 3 part and Herba Menthae 1 ~ 3 part;
Above-mentioned herbal mixture filling agent its preparation method, is undertaken by embodiment 1.
Clinical trial:
Test example: in 225 of Jinghai dairy farm raising in 2014, the milch cow in 40 80 days puerperal suffers from cow endometritis.
Clinical symptoms: suffer from cattle uterus secretions muddiness, color and luster is unclear, is mixed with purulent secretion, and with bad smell, two angles, examination per rectum uterus are loose or asymmetric, and quality sense is poor.
Result of the test: the traditional Chinese medicine perfusion agent obtained by the embodiment of the present invention 3, by every each nipple perfusion 30 ~ 40ml, administration every day 2 times, continuous use after 5 days examination per rectum cornua uteri contractile response good, quality is soft, secretions without muddiness, without bad smell.Through statistics, traditional Chinese medicine perfusion agent is 85.4% for the effective percentage of cow endometritis.
Above-mentioned detailed description of herbal mixture filling agent liquid being used for the treatment of cow endometritis and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore; in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.

Claims (4)

1. one kind is used for the treatment of the herbal mixture filling agent of cow endometritis, it is characterized in that, with weight parts, being made up of following medicinal materials: Radix Angelicae Sinensis 5 ~ 9 parts, the Radix Paeoniae Alba 5 ~ 8 parts, Fructus Toosendan 4 ~ 7 parts, Herba Leonuri 4 ~ 7 parts, 3 ~ 6 parts, Semen Persicae, Rhizoma Chuanxiong 3 ~ 6 parts, Rhizoma Cyperi 2 ~ 5 parts, Cortex Lycii 2 ~ 5 parts, Radix Bupleuri 1 ~ 3 part, Herba Menthae 1 ~ 3 part.
2. a kind of herbal mixture filling agent being used for the treatment of cow endometritis according to claim 1, it is characterized in that described traditional Chinese medicine perfusion agent is with weight parts, is made up of following medicinal materials: Radix Angelicae Sinensis 7 parts, the Radix Paeoniae Alba 7 parts, Fructus Toosendan 7 parts, Herba Leonuri 7 parts, 3 parts, Semen Persicae, Rhizoma Chuanxiong 3 parts, Rhizoma Cyperi 2 parts, Cortex Lycii 2 parts, Radix Bupleuri 1 part, Herba Menthae 1 part.
3. a kind of preparation method being used for the treatment of the herbal mixture filling agent of cow endometritis according to claim 1, is characterized in that comprising the following steps:
(1) following medicinal materials is taken by weight: Radix Angelicae Sinensis 5 ~ 9 parts, the Radix Paeoniae Alba 5 ~ 8 parts, Fructus Toosendan 4 ~ 7 parts, Herba Leonuri 4 ~ 7 parts, 3 ~ 6 parts, Semen Persicae, Rhizoma Chuanxiong 3 ~ 6 parts, Rhizoma Cyperi 2 ~ 5 parts, Cortex Lycii 2 ~ 5 parts, Radix Bupleuri 1 ~ 3 part, Herba Menthae 1 ~ 3 part;
(2) in raw material components, add whole medical material 10 times of water gagings, decoct 2 times, be respectively 2 hours and 1.5 hours, merge decoction liquor, filter, filtrate is concentrated in right amount, adds ethanol and makes alcohol content be 75%, leaves standstill, filter, filtrate recycling ethanol, add water standardize solution, adds the sodium benzoate of 3 ‰;
(3) bottle, sealing, sterilizing.
4. a kind of preparation method being used for the treatment of the herbal mixture filling agent of cow endometritis according to claim 3, is characterized in that medical material that described step (1) takes is with weight parts: Radix Angelicae Sinensis 7 parts, the Radix Paeoniae Alba 7 parts, Fructus Toosendan 7 parts, Herba Leonuri 7 parts, 3 parts, Semen Persicae, Rhizoma Chuanxiong 3 parts, Rhizoma Cyperi 2 parts, Cortex Lycii 2 parts, Radix Bupleuri 1 part, Herba Menthae 1 part.
CN201410608448.1A 2014-11-03 2014-11-03 Compound traditional Chinese medicine perfusion agent used for treating endometritis of dairy cow and preparation method of compound traditional Chinese medicine perfusion agent Pending CN104367746A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104998047A (en) * 2015-06-30 2015-10-28 太仓市爱农奶牛专业合作社 Traditional Chinese medicine used for treating dairy cow endometritis
CN105287763A (en) * 2015-11-20 2016-02-03 重庆光大(集团)有限公司 Traditional Chinese medicine composition capable of being used to treat endometritis of cows and preparation method of preparation thereof
CN115337357A (en) * 2022-09-30 2022-11-15 吉林医药学院 Saponaria officinalis-caulis et folium piperis soup and preparation method and application thereof
CN116870080A (en) * 2023-05-17 2023-10-13 宁夏农林科学院动物科学研究所(宁夏草畜工程技术研究中心) Traditional Chinese medicine compound preparation for treating beef cattle endometritis

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KR20130112490A (en) * 2012-04-04 2013-10-14 이규담 An vegetable absorber using psyllium husk and the use thereof

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104998047A (en) * 2015-06-30 2015-10-28 太仓市爱农奶牛专业合作社 Traditional Chinese medicine used for treating dairy cow endometritis
CN105287763A (en) * 2015-11-20 2016-02-03 重庆光大(集团)有限公司 Traditional Chinese medicine composition capable of being used to treat endometritis of cows and preparation method of preparation thereof
CN105287763B (en) * 2015-11-20 2019-07-05 重庆光大(集团)有限公司 A kind of Chinese medicine composition and its formulation method can be used for preventing and treating cow endometritis
CN115337357A (en) * 2022-09-30 2022-11-15 吉林医药学院 Saponaria officinalis-caulis et folium piperis soup and preparation method and application thereof
CN115337357B (en) * 2022-09-30 2024-01-26 吉林医药学院 Quillaja saponaria stem soup and preparation method and application thereof
CN116870080A (en) * 2023-05-17 2023-10-13 宁夏农林科学院动物科学研究所(宁夏草畜工程技术研究中心) Traditional Chinese medicine compound preparation for treating beef cattle endometritis

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Application publication date: 20150225