CN104784311A - Combined medicament for preventing and treating aftosa of animals and preparation method thereof - Google Patents
Combined medicament for preventing and treating aftosa of animals and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a combined medicament for preventing and treating aftosa of animals. The combined medicament comprises the following raw material medicines in part by weight: 1 to 2 parts of radices trichosanthis, 1 to 2 parts of aristolochiae lignum, 2 to 3 parts of scutellaria baicalensis, 2 to 3 parts of the rhizome of Chinese goldthread, 1 to 2 parts of fructus forsythiae, 1 to 2 parts of poria cocos, 1 to 2 parts of golden cypress, 1 to 2 parts of platycodon grandiflorum, 1 to 2 parts of angelica root, 1 to 2 parts of cape jasmine, 1 to 2 parts of the root of kudzu vine, 1 to 2 parts of cicada slough, 2 to 3 parts of fructus arctii, 1 to 2 parts of indigo naturalis and 1 to 2 parts of libanotus. The invention provides a uniform medicament formula; the combined medicament can be used for dealing with diseases of aftosa of a large group of animals and is simple to operate; when prepared powder and iodine glycerin are used together for 2 to 3 days, the diseases of aftosa of the animals can be healed. The invention provides a preparation method and application of the combined medicament for preventing and treating aftosa of the animals.
Description
Technical field
The invention belongs to veterinary drug clinical practice field.More particularly, the present invention relates to a kind of composition of medicine for preventing and treating animal aphtha hoof Huang and preparation method thereof.
Background technology
In recent years, the disease incidence probability of animal aphtha hoof Huang aspect is higher, and the disease of animal aphtha hoof Huang aspect comprises the stomatitis of pig, cattle and sheep, the diseases such as swine pox, sheep pox, infectiousness aphtha and Bauhinia variegata Linn festers, vesiculovirus rash.Domestic at Chinese veterinarian's clinicing aspect, have accumulated many experiences, wherein boil on the nape opposite the mouth, hoof Huang have very strong Chinese veterinarian's theoretical basis, find that pathogenic main cause is diseases caused by exogenous pathogenic factor six climate exopathogens dryness-fire, internal organs internal injury, its important pathomechanism is that heat heap soil or fertilizer over and around the roots stasis, combination of phlegm and heat and heat in the heart are got angry, leak in lip, skin, Bauhinia variegata Linn, its heat is sent out in table to festering.Be actually the fire of interior-heat to lead off in outer performance.Especially " tiger spot heart " that show artiodactyl which illustrates this point.At present, adopt liquid Acupuncture therapy more, but can only reach antipyretic, antibacterial, analgesic effect, and in Chinese medicine, because clinical syndrome differentiation is complicated, jumpbogroup morbidity cannot be tackled, its prescription is various, cannot unify, and is difficult to the shortcomings such as operation.Therefore provide a kind of unified Chinese prescription and for the solution of jumpbogroup medication be need the problem of solution badly.
Summary of the invention
An object of the present invention is to solve at least the problems referred to above and defect, and the advantage will illustrated at least is below provided.
In order to realize according to these objects of the present invention and other advantage, provide a kind of composition of medicine for preventing and treating animal aphtha hoof Huang, comprise the crude drug of following parts by weight: Radix Trichosanthis 1-2 part, Caulis Akebiae 1-2 part, Radix Scutellariae 2-3 part, Rhizoma Coptidis 2-3 part, Fructus Forsythiae 1-2 part, Poria 1-2 part, Cortex Phellodendri 1-2 part, Radix Platycodonis 1-2 part, Radix Angelicae Dahuricae 1-2 part, Fructus Gardeniae 1-2 part, Radix Puerariae 1-2 part, Periostracum Cicadae 1-2 part, Fructus Arctii 2-3 part, Indigo Naturalis 1-2 part, Olibanum 1-2 part, wherein Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the logical fire rushing down three Jiao of Fructus Gardeniae, heat conduction is descending, is principal agent; Be aided with Fructus Forsythiae and help principal agent eliminating fire and detoxication; Fructus Arctii, Radix Angelicae Dahuricae reducing swelling and alleviating pain, Poria cum Radix Pini's tranquilizing mind, Radix Trichosanthis clearing away heat and promoting production of body fluid, Caulis Akebiae clearing away heart-fire, diuresis, Radix Puerariae Periostracum Cicadae separates evil poison thoroughly, is all adjuvant drug; Radix Platycodonis, Indigo Naturalis, Olibanum evacuation of pus detumescence, granulation promoting pain relieving, and medicine carrying reaches disease institute, for making medicine.All medicines share, and play eliminating fire and detoxication altogether, the effect of dissipating blood stasis for subsidence of swelling.
Preferably, wherein, described crude drug is Radix Trichosanthis 1 part, Caulis Akebiae 1 part, Radix Scutellariae 2 parts, Rhizoma Coptidis 2 parts, Fructus Forsythiae 1 part, 1 part, Poria, Cortex Phellodendri 1 part, Radix Platycodonis 1 part, the Radix Angelicae Dahuricae 1 part, Fructus Gardeniae 1 part, Radix Puerariae 1 part, Periostracum Cicadae 1 part, Fructus Arctii 2 parts, Indigo Naturalis 1 part and Olibanum 1 part with parts by weight respectively, adopt unified prescription medicine, easily operate.
Preferably, wherein, its dosage form is powder, this kind of method improves the quality of Chinese medicine, improve the utilization rate of Chinese medicine, in use, micro-powder of Chinese herbs rapid dispersion suspending in water, normally drink for poultry through automatic drinking water apparatus, effective solve drug precipitation and the uneven and problem that causes drug effect to reduce of dosage.
Preferably, wherein, the preparation method of described powder: each raw material will be made 80-200 object powder after mixing, nanon ball-mill is used to make superfine powder in described powder again, superfine communication technique refers to and to combine with Chinese medicine theory, by Chinese crude drug, Chinese medicine extract, Chinese medicine preparation, the micronizations such as Chinese medicine formula, directly the cell of Chinese crude drug is smashed, due to plant amedica, the active ingredient of animal drugs is mainly distributed in cell and intercellular substance, based in cell, therefore comminution process for the purpose of Chinese crude drug cell will be broken be called " cellular level pulverizing " of Chinese medicine, the micro-powder of Chinese herbs adopting cellular level pulverizing method to obtain is called " cell grade micro-powder of Chinese herbs ", the Chinese medicine made based on cell grade micro-powder of Chinese herbs is called " cell grade ultrafine Chinese herb ", is called for short " ultrafine Chinese herb ", effective solves drug precipitation and the uneven and problem that causes drug effect to reduce of dosage.
Preferably, wherein, described ultra-micro powder diameter is less than 10 microns, is convenient to animal reaches drug administration object by drinking-water, makes the performance that superfine powder is conducive to herbal medicine efficacy, reach good therapeutic effect.
Preferably, wherein, for preventing and treating the preparation method of the composition of medicine of animal aphtha hoof Huang, comprise the following steps:
Step one, dry described crude drug to crisp, being mixed evenly is ground into 80-120 object powder;
Step 2, the powder obtained by step one is mixed into the saccharin sodium being equivalent to described powder weight 0.1%-0.3%, uses nanon ball-mill to make superfine powder; The diameter of wherein said superfine powder is less than 10 μm.
Preferably, wherein, for prevention and therapy animal aphtha hoof Huang; Its using method is as follows:
A, when promptly preventing, uses in drinking-water, and every 10L water adds preparation Chinese medicine 50g, freely drinks.
When b, treatment, adopt every 1L water to add preparation Chinese medicine 100g, often only gavage 50ml, once a day, be used in conjunction 2-3 days.
Described powder, adds that a small amount of saccharin sodium animal is acceptant to take, and easily absorbs, convenient operation after taking, and is applicable to the prevention and therapy for large animal population animal aphtha hoof Huang.
Preferably, wherein, when being in a bad way, coordinate and embrocate iodine glycerol, described iodine glycerol adopts following steps to make: potassium iodide 3 grams, adding distil water 3 milliliters, 1-3 gram of iodine is added in described liquor kalii iodide, then add glycerol to 100 milliliter mix homogeneously, heat in the heart cause outer sick aphtha of the mouth and tongue, wound that hoof casket festers, be subject to external environment infected by microbes, wound not easily heals, make iodine glycerol to work in coordination with described powder and nurse use altogether, skin wound can be made to restrain healing, reach good therapeutic effect.
The present invention at least comprises following beneficial effect:
1, the present invention have developed the composition of medicine for preventing and treating animal aphtha hoof Huang, provides unified medicament composing prescription, can deal with the disease of jumpbogroup animal aphtha hoof Huang, simple to operate.
2, described crude drug is made powder by the present invention, realizes jumpbogroup medication, and can realize suitability for industrialized production.
3, powder of the present invention is added to the water and drinks for animal, and convenient operation, therapeutic effect is remarkable.
4, powder of the present invention and iodine glycerol use jointly, within 2-3 days, can cure the aphtha hoof Huang disease of animal.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
The present invention is described in further detail below, can implement according to this with reference to description word to make those skilled in the art.
Should be appreciated that used hereinly such as " to have ", other element one or more do not allotted in " comprising " and " comprising " term or the existence of its combination or interpolation.
For preventing and treating the composition of medicine of animal aphtha hoof Huang, comprise the crude drug of following parts by weight: Radix Trichosanthis 1-2 part, Caulis Akebiae 1-2 part, Radix Scutellariae 2-3 part, Rhizoma Coptidis 2-3 part, Fructus Forsythiae 1-2 part, Poria 1-2 part, Cortex Phellodendri 1-2 part, Radix Platycodonis 1-2 part, Radix Angelicae Dahuricae 1-2 part, Fructus Gardeniae 1-2 part, Radix Puerariae 1-2 part, Periostracum Cicadae 1-2 part, Fructus Arctii 2-3 part, Indigo Naturalis 1-2 part, Olibanum 1-2 part, wherein Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the logical fire rushing down three Jiao of Fructus Gardeniae, heat conduction is descending, is principal agent; Be aided with Fructus Forsythiae and help principal agent eliminating fire and detoxication; Fructus Arctii, Radix Angelicae Dahuricae reducing swelling and alleviating pain, Poria cum Radix Pini's tranquilizing mind, Radix Trichosanthis clearing away heat and promoting production of body fluid, Caulis Akebiae clearing away heart-fire, diuresis, Radix Puerariae Periostracum Cicadae separates evil poison thoroughly, is all adjuvant drug; Radix Platycodonis, Indigo Naturalis, Olibanum evacuation of pus detumescence, granulation promoting pain relieving, and medicine carrying reaches disease institute, for making medicine.All medicines share, and play eliminating fire and detoxication altogether, the effect of dissipating blood stasis for subsidence of swelling.
In another kind of example, described crude drug is Radix Trichosanthis 1 part, Caulis Akebiae 1 part, Radix Scutellariae 2 parts, Rhizoma Coptidis 2 parts, Fructus Forsythiae 1 part, 1 part, Poria, Cortex Phellodendri 1 part, Radix Platycodonis 1 part, the Radix Angelicae Dahuricae 1 part, Fructus Gardeniae 1 part, Radix Puerariae 1 part, Periostracum Cicadae 1 part, Fructus Arctii 2 parts, Indigo Naturalis 1 part and Olibanum 1 part with parts by weight respectively.
In another kind of example, in the above-described embodiment, the dosage form that described crude drug is made is powder, this kind of method improves the quality of Chinese medicine, improve the utilization rate of Chinese medicine, in use, micro-powder of Chinese herbs rapid dispersion suspending in water, normally drink for poultry through automatic drinking water apparatus, effective solve drug precipitation and the uneven and problem that causes drug effect to reduce of dosage.。
In another kind of example, in the above-described embodiment, the preparation method of described powder: each raw material will be made 80-200 object powder after mixing, nanon ball-mill is used to make superfine powder in described powder again, use nanon ball-mill model for wi94924, superfine communication technique refers to and to combine with Chinese medicine theory, by Chinese crude drug, Chinese medicine extract, Chinese medicine preparation, the micronizations such as Chinese medicine formula, directly the cell of Chinese crude drug is smashed, due to plant amedica, the active ingredient of animal drugs is mainly distributed in cell and intercellular substance, based in cell, therefore comminution process for the purpose of Chinese crude drug cell will be broken be called " cellular level pulverizing " of Chinese medicine, the micro-powder of Chinese herbs adopting cellular level pulverizing method to obtain is called " cell grade micro-powder of Chinese herbs ", the Chinese medicine made based on cell grade micro-powder of Chinese herbs is called " cell grade ultrafine Chinese herb ", is called for short " ultrafine Chinese herb ", effective solves drug precipitation and the uneven and problem that causes drug effect to reduce of dosage.
In another kind of example, in the above-described embodiment, described ultra-micro powder diameter is less than 10 microns, is convenient to animal reaches drug administration object by drinking-water, makes the performance that superfine powder is conducive to herbal medicine efficacy, reach good therapeutic effect.
In another kind of example, in the above-described embodiment, for preventing and treating the preparation method of the composition of medicine of animal aphtha hoof Huang, comprise the following steps:
Step one, dry described crude drug to crisp, being mixed evenly is ground into 80-120 object powder;
Step 2, the powder obtained by step one is mixed into the saccharin sodium being equivalent to described powder weight 0.1%-0.3%, uses nanon ball-mill to make superfine powder; The diameter of wherein said superfine powder is less than 10 μm.
In another kind of example, in the above-described embodiment, for prevention and therapy animal aphtha hoof Huang; Its using method is as follows:
A, when promptly preventing, uses in drinking-water, and every 10L water adds preparation Chinese medicine 50g, freely drinks.
When b, treatment, adopt every 1L water to add preparation Chinese medicine 100g, often only gavage 50ml, once a day, be used in conjunction 2-3 days.
Described powder, adds that a small amount of saccharin sodium animal is acceptant to take, and easily absorbs, convenient operation after taking, and is applicable to the prevention and therapy for large animal population animal aphtha hoof Huang.
In another kind of example, in the above-described embodiment, when being in a bad way, coordinate and embrocate iodine glycerol, described iodine glycerol adopts following steps to make: potassium iodide 3 grams, adding distil water 3 milliliters, 1-3 gram of iodine is added in described liquor kalii iodide, then add glycerol to 100 milliliter mix homogeneously, heat in the heart cause outer sick aphtha of the mouth and tongue, wound that hoof casket festers, be subject to external environment infected by microbes, wound not easily heals, make iodine glycerol to work in coordination with described powder and nurse use altogether, skin wound can be made to restrain healing, reach good therapeutic effect.
Wherein in an embodiment, the present invention is for preventing and treating composition of medicine of animal aphtha hoof Huang and preparation method thereof:
(1), by its equal portions Radix Trichosanthis 1 part, Caulis Akebiae 1 part, Radix Scutellariae 2 parts, Rhizoma Coptidis 2 parts, Fructus Forsythiae 1 part, 1 part, Poria, Cortex Phellodendri 1 part, Radix Platycodonis 1 part, the Radix Angelicae Dahuricae 1 part, Fructus Gardeniae 1 part, Radix Puerariae 1 part, Periostracum Cicadae 1 part, Fructus Arctii 2 parts, Indigo Naturalis 1 part, Olibanum 1 part first dry crude drug to crisp, being mixed evenly is ground into 80 ~ 120 object powder.
(2) above-mentioned powder and appropriate saccharin sodium are added super micron mill to carry out shattering into superfine powder.Diameter is less than the industrial technology of the high-tech content of 10 μm of powder body, has that speed is fast, the time is short, particle diameter is thin, is evenly distributed, the feature such as conservation.
(3) potassium iodide 3 grams in proportion, adds aquae destillata 3 milliliters, add after dissolving iodine 1-3 gram fully dissolve after add glycerol to 100 milliliter and mix and obtain for subsequent use.
In order to effect of the present invention is described, it is as follows that inventor provides clinical practice to test:
Experiment 1
In the clinical practice of oof disease
On March 13rd, 2014, eruption and prevalence oof sick its in Mianyang City sheep raising family, Sichuan Province is characterized in that the skin at the places such as lip, bicker, nostril periphery and mucosa form pimple, blister and even pus bubble, last ulceration forms the thick crust of excipuliform, there is rubbing by force mouth after taking crust off, to search for food time serious difficulty, lassitude, body temperature raise, search for food and ruminate minimizing, and last exhaustion is dead.Especially lamb falls ill even more serious the most.According to clinical setting, determine to use this method.
(1) use in drinking-water, every 10L water adds preparation Chinese medicine 50g, freely drinks.
(2) adopt every 1L water to add preparation Chinese medicine 100g to the serious milkfed lamb of morbidity, often only gavage 50ml.Once a day, be used in conjunction 2-3 days,
(3) place's fingernail such as pimple, blister and even pus bubble and incrustation blackout is formed to the skin at the places such as lip, bicker, nostril periphery and mucosa and scratch the new ulcer surface of formation, embrocate above-mentioned special iodine glycerol, once a day.
Medication the 3rd day, the state of an illness does not further develop, and face convergence healing of festering, healing is good.
Experiment 2
In the clinical practice of pig aphtha hoof anthrax
On January 15th, 2014,35, raiser pig farm, Fuxin, Liaoning sow (8 sucklings), 135 growing and fattening pigs, have 80 nursery pig, a night gets up, and sees that the heating of indivedual pig is not eaten, be reluctant to move, the dead several head of suckling piglet, next day checks discovery further, lip has blister, red swelling of gingiva, tongue limit bubble, swelling between hoof, eat while stop, feed intake declines, and seems very painful appearance.The burning hot aphtha hoof anthrax of heart channel is diagnosed as according to clinical symptoms.Carried out to the whole audience dispensing treatment of drinking water, using dosage water per ton adds this product 5KG, gavages suckling piglet, is coated with puts special iodine glycerol on the skin to Bauhinia variegata Linn rotten position, and medication basic rehabilitation afterwards on the three, between oral cavity and hoof, swelling disappears.Maintain medication one week, except dead 16 of suckling piglet, other whole rehabilitations are normally eaten food.In in October, 2013 and in April, 2014 and May successively in several areas such as Liaoning new people, Liaozhong, Black Hills, the 3800 bull pigs on ten Yu Jia pig farms have carried out trying to control, as long as within 3 days, just use medicine of the present invention at premorbid, do not go out three after medication, get final product basic rehabilitation.
Experiment 3
At the control and application of sheep pox
Sheep pox its feature sick: incubation period is 6 ~ 8 days, sick sheep heating, body temperature raises and reaches 40 ~ 42 DEG C, lassitude, loss of appetite or do not eat, sick just nostril is inaccessible, P&R is accelerated, occasionally there is cough, some goat stream serosity or mucus nasal mucus, eyelid swelled, conjunctival congestion, there is serosity secretions, after 1 ~ 2 day, without hair position such as nares, face, ear, back, thorax abdomen, extremity are without hair-fields, there are two points to the block rash of a yuan coin-size, after rash block ulceration, weak yellow liquid is had to flow out, after 3 ~ 4 days, the pustule of ulceration is not had gradually to be absorbed, drying shrinkage, form brown crust.In a few days, decrustation, namely the cicatrix leaving over color lighter heals, and overall process is 3 ~ 4 weeks.Goatpox can concurrent respiratory tract, digestive tract disease and arthritis, can cause pyaemia septica and dead time serious.In November, 2013, Sichuan Guangyuan city puts flock of sheep in a suitable place to breed and occurs that this is sick, the effect of the good control of getting in the same way.
Although embodiment of the present invention are open as above, it is not restricted to listed in description and embodiment utilization.It can be applied to various applicable the field of the invention completely.For those skilled in the art, can easily realize other amendment.Therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details.
Claims (8)
1. one kind for preventing and treating the composition of medicine of animal aphtha hoof Huang, it is characterized in that, comprise the crude drug of following parts by weight: Radix Trichosanthis 1-2 part, Caulis Akebiae 1-2 part, Radix Scutellariae 2-3 part, Rhizoma Coptidis 2-3 part, Fructus Forsythiae 1-2 part, Poria 1-2 part, Cortex Phellodendri 1-2 part, Radix Platycodonis 1-2 part, Radix Angelicae Dahuricae 1-2 part, Fructus Gardeniae 1-2 part, Radix Puerariae 1-2 part, Periostracum Cicadae 1-2 part, Fructus Arctii 2-3 part, Indigo Naturalis 1-2 part, Olibanum 1-2 part.
2. the composition of medicine of prevention and therapy animal aphtha hoof Huang as claimed in claim 1, it is characterized in that, described crude drug is Radix Trichosanthis 1 part, Caulis Akebiae 1 part, Radix Scutellariae 2 parts, Rhizoma Coptidis 2 parts, Fructus Forsythiae 1 part, 1 part, Poria, Cortex Phellodendri 1 part, Radix Platycodonis 1 part, the Radix Angelicae Dahuricae 1 part, Fructus Gardeniae 1 part, Radix Puerariae 1 part, Periostracum Cicadae 1 part, Fructus Arctii 2 parts, Indigo Naturalis 1 part and Olibanum 1 part with parts by weight respectively.
3. the composition of medicine of prevention and therapy animal aphtha hoof Huang as claimed in claim 2, it is characterized in that, its dosage form is powder.
4. the composition of medicine of prevention and therapy animal aphtha hoof Huang as claimed in claim 3, it is characterized in that, the preparation method of described powder: each raw material will be made 80-200 object powder after mixing, then use nanon ball-mill to make superfine powder in described powder.
5. the composition of medicine of prevention and therapy animal aphtha hoof Huang as claimed in claim 4, it is characterized in that, described ultra-micro powder diameter is less than 10 microns.
6. a preparation method for the composition of medicine for preventing and treating animal aphtha hoof Huang as described in claim 1-5 any one, is characterized in that, comprise the following steps:
Step one, dry described crude drug to crisp, being mixed evenly is ground into 80-120 object powder;
Step 2, the powder obtained by step one is mixed into the saccharin sodium being equivalent to described powder weight 0.1%-0.3%, uses nanon ball-mill to make superfine powder; The diameter of wherein said superfine powder is less than 10 μm.
7. a purposes for the composition of medicine for preventing and treating animal aphtha hoof Huang as described in claim 1-5 any one, is characterized in that, for prevention and therapy animal aphtha hoof Huang; Its using method is as follows:
A, during prevention, uses in drinking-water, and every 10L water adds preparation Chinese medicine 50g, freely drinks.
When b, treatment, adopt every 1L water to add preparation Chinese medicine 100g, often only gavage 50ml, once a day, be used in conjunction 2-3 days.
8. the purposes of the composition of medicine of prevention and therapy animal aphtha hoof Huang as claimed in claim 7, it is characterized in that, when being in a bad way, coordinate and embrocate iodine glycerol, described iodine glycerol adopts following steps to make: potassium iodide 3 grams, adding distil water 3 milliliters, adds 1-3 gram of iodine in described liquor kalii iodide, then adds glycerol to 100 milliliter mix homogeneously.
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Cited By (1)
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| CN108567864A (en) * | 2016-04-01 | 2018-09-25 | 重庆市畜牧科学院 | Chinese medicine preparation for treating sore mouth virus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104415184A (en) * | 2013-08-28 | 2015-03-18 | 杜淑卿 | Compound aphtha powder |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104415184A (en) * | 2013-08-28 | 2015-03-18 | 杜淑卿 | Compound aphtha powder |
Non-Patent Citations (2)
| Title |
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| 范开: "《中兽医方剂辩证应用及解析》", 31 January 2006, 化学工业出版社 * |
| 陈绍辉等: "中西医结合治疗山羊口疮病例", 《中国兽医杂志》 * |
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| CN108567864A (en) * | 2016-04-01 | 2018-09-25 | 重庆市畜牧科学院 | Chinese medicine preparation for treating sore mouth virus |
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