CN103385927A - Traditional Chinese medicine composition for the treatment of animal acariasis - Google Patents
Traditional Chinese medicine composition for the treatment of animal acariasis Download PDFInfo
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- CN103385927A CN103385927A CN201310297335XA CN201310297335A CN103385927A CN 103385927 A CN103385927 A CN 103385927A CN 201310297335X A CN201310297335X A CN 201310297335XA CN 201310297335 A CN201310297335 A CN 201310297335A CN 103385927 A CN103385927 A CN 103385927A
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Abstract
The present invention provides a traditional Chinese medicine composition for the treatment of animal acariasis, and the composition includes the following ingredients, by weight: 180-250 parts of adonis coerulea, 220-300 parts of clove, 180-250 parts of pseudolaricis cortex, and 120-200 parts of sophora flavescens. The traditional Chinese medicine composition of the present invention has the characteristics of being safe, effective, low-toxic and non-polluting in the treatment of animal acariasis; and can also promote the recovery of damage fur of animals, reduceing economic losses; has no residue in use, ensuring the safety of food of animal origin; has a simple preparation process, low costs, and can be prepared in a variety of preparations; is convenient to use by being directly applied or sprayed on affected areas; and has a cure rate up to 80%, and an effective rate up to 90%.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, be specifically related to a kind of Chinese medicine composition for the treatment of the animal acaricide and its preparation method and application.
Background technology
The animal acaricide is acarid zooparasite body surface and the chronic epizootic disease of a kind of animal that causes; its cause of disease is acaricide, itch mite; mainly betide autumn end, winter and the early spring; by infected animal and the direct or indirect contact infection of healthy animal; extensively betide the animals such as cattle, sheep, horse, dog, rabbit, chicken; also can infect to the people, in pastoral area, farming and pastoral area and large-scale cultivation field infection rate and sickness rate all higher.Animal occur this disease main manifestations be appetite depression or useless absolutely, become thin, by hair, come off etc., have a strong impact on fertility performance and the economic worth of animal, restriction animal husbandry sound development and economic benefit.At present, the medicine that is used for the treatment of the animal acaricide is mainly chemosynthesis and antibiotics, and is as clean in ivermectin, demodicid mite etc., and this type of medicine is in effective control animal acaricide,, due to the generation of drug residue and drug resistance, the problems such as public health, food safety and ecological environment have been caused.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of the animal acaricide and preparation method thereof, said composition has therapeutic effect to the animal acaricide, has killing parasites for relieving itching, promotes damaged skin to recover, drug residue free, the advantage that toxic and side effects is little.
A kind of Chinese medicine composition for the treatment of the animal acaricide provided by the invention comprises each component of following mass fraction: 180 ~ 250 parts, blue flower side gold small cup, 220 ~ 300 parts of Flos Caryophyllis, 180 ~ 250 parts of Cortex Pseudolariciss, 120 ~ 200 parts of Radix Sophorae Flavescentiss.
The traditional Chinese medicine composition for treating animal acaricide that is combined to form in this scope all has certain effect.
Further, described Chinese medicine composition comprises each component of following mass fraction: 250 parts, blue flower side gold small cup, 300 parts of Flos Caryophyllis, 250 parts of Cortex Pseudolariciss, 200 parts of Radix Sophorae Flavescentiss; Or blue 180 parts, side gold small cup, 220 parts of Flos Caryophyllis, 180 parts of Cortex Pseudolariciss, 120 parts of the Radix Sophorae Flavescentiss spent; Or blue 220 parts, side gold small cup, 250 parts of Flos Caryophyllis, 220 parts of Cortex Pseudolariciss, 160 parts of the Radix Sophorae Flavescentiss spent.
At this moment, the best results for the treatment of animal acaricide, cure rate is 80%, effective percentage is 90%.
Second purpose of the present invention is to provide a kind of medicine, and it comprises Chinese medicine composition described above.
Further, the dosage form of described medicine is powder, ointment, spray.
The 3rd purpose of the present invention is to provide a kind of preparation method of Chinese medicine composition of above-mentioned treatment animal acaricide, and step is as follows:
(1), take by weight ratio each medicine material;
(2), will claim each medicine material pulverize, sieve after, extract, concentrate with the mixed liquor of the arbitrary proportion of alcohol through water or alcohol or water, be prepared from.
Further, also comprise the step that adds adjuvant commonly used after described step (2).
The 4th purpose of the present invention is to provide the application of Chinese medicine composition in the medicine of preparation treatment animal acaricide.
In the present invention, as traditional Tibetan medicine, blue flower side gold small cup has significant acaricidal action; And modern study proof Flos Caryophylli has good insecticidal action; Cortex Pseudolaricis has the killing pests and suppressing bacteria effect, promotes the recovery of damaged skin microenvironment when killing acarid; In this medicine, but Radix Sophorae Flavescentis is when killing acarid, and it can also promote the recovery of the impaired fur of animal, reduces the economic loss of being brought by acarid.
The invention has the advantages that: Chinese medicine composition of the present invention aspect treatment animal acaricide, has safety, effective, low, the free of contamination characteristics of toxicity; Simultaneously, can also promote the recovery of the impaired fur of animal, reduce economic loss; Medicine is noresidue in use, has guaranteed the safety of animal derived food; Preparation technology is simple, and cost is low, can conveniently be prepared into various preparations; Easy to use, directly be coated with to put affected part on the skin or spray affected part and get final product; Cure rate is up to 80%, and effective percentage is up to 90%.
The specific embodiment
Following embodiment is convenient to understand better the present invention, but does not limit the present invention.Experimental technique in following embodiment, if no special instructions, be conventional method.
The Preparation Example 1 of Chinese medicine composition of the present invention
Take 220 parts, dry indigo plant flower side gold small cup, 250 parts of Flos Caryophyllis, 220 parts of Cortex Pseudolariciss, 160 parts of Radix Sophorae Flavescentiss, pulverize, and with 50% soak with ethanol, spends the night, hot bath refluxed 1～5 hour, extracted each 1～4 hour 1～4 time, merge extractive liquid,, sucking filtration, use the Rotary Evaporators evaporation and concentration, freeze-drying, extractum is pulverized, crossed the 80-100 mesh sieve, mix the Chinese medicine composition composition powders that both must treat the animal acaricide.
The outer used time, with plant rusting heat, the Chinese medicine composition composition powders furnishing runny plaste shape with above-mentioned preparation, be coated with and put affected part on the skin, gets final product.
The Preparation Example 2 of Chinese medicine composition of the present invention
(1), take 250 parts, dry blue flower side gold small cup, 300 parts of Flos Caryophyllis, 250 parts of Cortex Pseudolariciss, 200 parts of Radix Sophorae Flavescentiss, pulverize, and with 50% soak with ethanol, spends the night, hot bath refluxed 1～5 hour, extracted each 1～4 hour 1～4 time, merge extractive liquid,, sucking filtration, use the Rotary Evaporators evaporation and concentration, freeze-drying, extractum is pulverized, be put in dry ventilation standby.
(2), stearic acid 120g, glyceryl monostearate 35g, liquid Paraffin 60g, lanoline 50g are placed in container, heating in water bath is to fusing;
(3), separately the medical material of getting in glycerol 40g, triethanolamine 4g, distilled water and step (1) after pulverizing is placed in another beaker, heating for dissolving together;
(4), azone 30g is joined in the melt that step (2) prepares, simultaneously while the product that adds step (3) to prepare, stir and make it even, adding distil water, to 1000ml, is cooled to room temperature, must prevent and treat the Chinese medicine composition ointment of animal acaricide.
The outer used time, be coated with medicine to put affected part on the skin, gets final product.
The Preparation Example 3 of Chinese medicine composition of the present invention
Take 180 parts, dry blue flower side gold small cup, 220 parts of Flos Caryophyllis, 180 parts of Cortex Pseudolariciss, 120 parts of Radix Sophorae Flavescentiss, pulverize, and with 50% soak with ethanol, spends the night, hot bath refluxed 1～5 hour, extracted each 1～4 hour 1～4 time, merge extractive liquid,, sucking filtration, use the Rotary Evaporators evaporation and concentration to the 300ml left and right, add azone 30g, adding distil water, to 1000ml, is made spray liquid, fill in the spray bottle, is put in dry ventilation standby, obtains Chinese medicine composition spray of the present invention.
The outer used time, herbal sprinkling, to affected part, is got final product., for toy or house pet, also medicine can be dissolved in large water gaging and carry out dipping or bathing.
The Application Example of Chinese medicine composition of the present invention
1. experimental animal
The rabbit of natural infection acarid, body weight 1.8～2.2 kg, Lanzhou Institute of Biological Products's Experimental Animal Center provides.
2. test grouping and administration
50 rabbits that infect acarid are divided into five groups at random, and first group of powder that adopts embodiment 1 preparation,, with plant rusting heat,, with powder furnishing runny plaste shape, be coated with and put affected part on the skin, every three days, smears once, smears altogether three times; Second group of ointment that adopts embodiment 2 preparations, smeared medicine every three days to rabbit external auditory meatus affected part, smears altogether three times; The 3rd group of spray that adopts embodiment 3 preparations,, smeared three times to rabbit external auditory meatus affected part spraying medicine altogether every three days; The 4th group of employing " wiping scabies side " powder, it constitutes 120 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 120 parts of Fructus Gleditsiae Abnormalis, 30 parts of Fructus Crotonis, 9 parts of Realgars, 6 parts of Calomelass, pulverizes, and, with plant rusting heat,, with powder furnishing runny plaste shape, is coated with and puts affected part on the skin, every three days, smears once, smears altogether three times; The 5th group as the blank group, every three days, to rabbit external auditory meatus affected part, smears glycerol, smears three times.Observed altogether 15 days for above-mentioned two groups.
4. curative effect determinate standard
Recovery from illness: rabbit external auditory meatus has no crust, scrapes the skin that takes a morsel and examines under a microscope and have no polypide.
Take a turn for the better: rabbit external auditory meatus crust obviously reduces, and the scraping crust is examined under a microscope polypide quantity and reduced.
Invalid: rabbit external auditory meatus crust has no minimizing, examines under a microscope polypide quantity and has no minimizing.
5 results
Applying Chinese medicine composition of the present invention smears treatment to suffer from the rabbit result as follows: the cure rate of test 1 group (powder) is 80%, total effective rate 90%; Test the cure rate 80% of 2 groups, total effective rate 90%; Test the cure rate 70% of 3 groups, total effective rate 90%; Test simultaneously in 1 group to 3 groups, suffering from the rabbit skin of external auditory canal, to recover to wipe scabies side's group good.The cure rate 60% of " wiping scabies side ", total effective rate 80%; The blank group has no recovery from illness and takes a turn for the better.Traditional Chinese medicine composition for treating rabbit acaricide of the present invention has good effect as can be seen from the results, sees table 1 for details.
It should be noted that finally: the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment, the present invention is had been described in detail, for a person skilled in the art, it still can be modified to the technical scheme that aforementioned each embodiment puts down in writing, and perhaps part technical characterictic wherein is equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (7)
1. Chinese medicine composition for the treatment of the animal acaricide, comprise each component of following mass fraction: 180 ~ 250 parts, blue flower side gold small cup, 220 ~ 300 parts of Flos Caryophyllis, 180 ~ 250 parts of Cortex Pseudolariciss, 120 ~ 200 parts of Radix Sophorae Flavescentiss.
2. the Chinese medicine composition for the treatment of according to claim 1 animal acaricide, it is characterized in that: described Chinese medicine composition comprises each component of following mass fraction:
250 parts, blue flower side gold small cup, 300 parts of Flos Caryophyllis, 250 parts of Cortex Pseudolariciss, 200 parts of Radix Sophorae Flavescentiss; Or
180 parts, blue flower side gold small cup, 220 parts of Flos Caryophyllis, 180 parts of Cortex Pseudolariciss, 120 parts of Radix Sophorae Flavescentiss; Or
220 parts, blue flower side gold small cup, 250 parts of Flos Caryophyllis, 220 parts of Cortex Pseudolariciss, 160 parts of Radix Sophorae Flavescentiss.
3. medicine, it comprises the described Chinese medicine composition of claim 1 or 2.
4. medicine according to claim 3, it is characterized in that: the dosage form of described medicine is powder, ointment, spray.
5. the preparation method of the Chinese medicine composition of the described treatment of a claim 1 or 2 animal acaricide, step is as follows:
(1), take by weight ratio each medicine material;
(2), will claim each medicine material pulverize, sieve after, extract, concentrate with the mixed liquor of the arbitrary proportion of alcohol through water or alcohol or water, be prepared from.
6. preparation method according to claim 5, it is characterized in that: described step also comprises the step that adds adjuvant commonly used after (2).
7. the application of the described Chinese medicine composition of claim 1 or 2 in the medicine of preparation treatment animal acaricide.
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Cited By (3)
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| CN103960315A (en) * | 2014-05-15 | 2014-08-06 | 蒋国琴 | Anti-mite Chinese medicinal herb bag |
| CN105726625A (en) * | 2016-02-04 | 2016-07-06 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition used for treating dog and cat acariasis and preparation method and application thereof |
| CN107158211A (en) * | 2017-06-29 | 2017-09-15 | 阿保地 | A kind of desinsection Chinese medicine composition and preparation method thereof |
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| CN107158211A (en) * | 2017-06-29 | 2017-09-15 | 阿保地 | A kind of desinsection Chinese medicine composition and preparation method thereof |
| CN107158211B (en) * | 2017-06-29 | 2020-08-11 | 阿保地 | Traditional Chinese medicine composition for killing ticks and preparation method thereof |
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Application publication date: 20131113 |