CN102670735A - Anti-dandruff Chinese medicinal composition and application thereof to anti-dandruff external application agent - Google Patents
Anti-dandruff Chinese medicinal composition and application thereof to anti-dandruff external application agent Download PDFInfo
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- CN102670735A CN102670735A CN2012101735947A CN201210173594A CN102670735A CN 102670735 A CN102670735 A CN 102670735A CN 2012101735947 A CN2012101735947 A CN 2012101735947A CN 201210173594 A CN201210173594 A CN 201210173594A CN 102670735 A CN102670735 A CN 102670735A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses an anti-dandruff Chinese medicinal composition and an application thereof to an anti-dandruff external application agent. The Chinese medicinal composition is prepared by milkwort roots, garden balsam stems, virgate wormwood herbs, fortune's drynaria rhizome, roots of straight ladybell and Chinese ivy stems. Extracts of the Chinese medicine composition are capable of greatly inhibiting fungi and bacteria of malassezia furfur, escherichia coli and the like, have a good anti-dandruff function, and can be used for preparing the anti-dandruff external application agent.
Description
Technical field
The present invention relates to a kind of composite Chinese medicine composition, the extract of said composition has the anti-dandruff function, can be applied to remove the external agent of the dandruff.
Background technology
Under normal circumstances, the epidermis cell at scalp place because the cell of those basal layeres ceaselessly breeds, and releases to the surface, at last these cell maturations, become the horny layer that does not have life and come off.When scalp was very healthy, the cell that comes off was the powder that we are difficult for discovering, and also just can't see the dandruff.But when scalp went wrong, epidermal area just can not be ripe well, so peel off large stretch ofly, and the dandruff that Here it is.
The reason that the dandruff produces mainly contains two aspects: the one, and microorganism (like fungus and antibacterials such as Malassezia furfurs) is infected and is caused the hypodermal cell division to be accelerated; The 2nd, sebum secretion is too vigorous, and sebum is attached on the scalp with the cell that comes off, and just becomes the dandruff in small, broken bits after the drying.So anti-dandruff the best way suppresses microbial growth exactly and suppresses sebum secretion.
Dandruff removing agent commonly used in the anti-dandruff external agent at present has salicylic acid, pyrithione zinc (ZPT), ketoconazole, climbazole (climbazole) and pyridone ethanolamine (Octopirox) etc.These dandruff removing agents mainly reach the anti-dandruff purpose through suppressing microorganism.These dandruff removing agents are the material of chemosynthesis, and are bigger to the zest of human body, are cosmetics and limit the use of material.Development along with society; The raising of people's living standard; Also increasingly high to the requirement of cosmetics safety property; Particularly many safety issues have appearred in cosmetic industry in recent years, impel people increasingly high to green, safe, healthy cry, thereby have advanced the Application and Development of natural dandruff removing agent.Patent of invention ZL200910094201.1 discloses a kind of Chinese medicine shampoo of antipruritic anti-dandruff, and Chinese medicine ingredients is made up of the Cacumen Platycladi of 0.25-8 weight portion, the Fructus Cnidii of 0.25-8 weight portion, the Semen Sapindi Delavayi of 0.25-8 weight portion, the Herba Rabdosiae glaucocalycis of 0.25-8 weight portion; Patent of invention CN201110398740.1 discloses a kind of Chinese medicine scurf removing shampoo water and preparation method thereof, and described Chinese medicine extract comprises following parts by weight of Chinese traditional medicine extract: 1～5 part of Radix Paeoniae Rubra microwave extraction thing, 1～5 part of Fructus Xanthii microwave extraction thing, 1～5 part of Semen Sesami Nigrum microwave extraction thing, 1～3 part of Folium Artemisiae Argyi sonicated extract, 1～3 part of Radix Paeoniae Rubra sonicated extract, 1～5 part of Fructus Xanthii sonicated extract.The present invention then adopts the Chinese medicine composition low to the human body zest, that toxicity is low as fungus and bacterial inhibitors such as Malassezia furfurs, reaches the purpose of anti-dandruff.
Summary of the invention
The objective of the invention is provides a kind of Chinese medicine composition in order to overcome the defective of chemosynthesis dandruff removing agent, and the extract of this Chinese medicine composition can suppress fungus and antibacterials such as Malassezia furfur, has the function of anti-dandruff.
For reaching the object of the invention, the present invention has adopted following technical scheme:
A kind of Chinese medicine composition with anti-dandruff function is characterized in that comprising following components in weight percentage:
For obtaining the extract of above-mentioned Chinese medicine composition, the present invention has adopted following technical scheme: the Radix Polygalae in the above-mentioned Chinese medicine composition, Herba speranskiae tuberculatae, Herba Artemisiae Scopariae, hair Rhizoma Zingiberis Recens, Radix Adenophorae (Radix Glehniae), Caulis Hederae Sinensis are pulverized, and the back mix homogeneously sieves; Add and extract solvent; Heating and refluxing extraction 1-3 time, merge extractive liquid, is with activated carbon decolorizing, filtration; Filtrating promptly gets through being evaporated to paste.The extraction solvent that uses among the present invention can adopt water, ethanol, ethanol water.
Second purpose of the present invention is that the extract with above-mentioned Chinese medicine composition is used for anti-dandruff external agent, makes stable in properties, respond well anti-dandruff external agent.
For realizing second purpose of the present invention; The present invention has adopted following technical scheme: the extract of above-mentioned Chinese medicine composition is used to prepare anti-dandruff external agent; It is characterized in that containing in the anti-dandruff external agent extract of above-mentioned Chinese medicine composition; Its consumption is 0.05-20%, and preferable amount is 0.5-10%.Except containing above-mentioned Chinese medicine composition extract, can suitably add the common composition that is fit to anti-dandruff external agent use as required, like matrix components such as wetting agent, hair care agent, water, surfactants.
The not special restriction of the dosage form of anti-dandruff external agent can be solution, emulsion, cream frost shape, spray etc.
Beneficial effect of the present invention: the extract of Chinese medicine composition of the present invention has very strong inhibition and suppresses fungus and bacterial actions such as Malassezia furfur, escherichia coli, has the dandruff of removal function.
The specific embodiment
Below come the present invention is further described through specific embodiment, but these embodiment are not limitations of the present invention just in order to explain.
The preparation of embodiment 1 Chinese medicine composition (I) and extract thereof
Get Radix Polygalae, Herba speranskiae tuberculatae, Herba Artemisiae Scopariae, hair Rhizoma Zingiberis Recens, Radix Adenophorae (Radix Glehniae), each 100g of Caulis Hederae Sinensis, pulverize, excessively mix homogeneously behind 40 mesh sieves; The adding mass fraction is 70% ethanol water 4.8kg, and heating and refluxing extraction 90min repeats to extract 2 times; Merge extractive liquid; With activated carbon decolorizing, filtration, filtrating promptly gets through being evaporated to paste.
The preparation of embodiment 2 Chinese medicine compositions (II) and extract thereof
Get Radix Polygalae 150g, Herba speranskiae tuberculatae 150g, Herba Artemisiae Scopariae 40g, hair Rhizoma Zingiberis Recens 60g, Radix Adenophorae (Radix Glehniae) 60g, Caulis Hederae Sinensis 40g, pulverize, excessively mix homogeneously behind 40 mesh sieves; The adding mass fraction is 30% ethanol water 5kg, and heating and refluxing extraction 60min repeats to extract 3 times; Merge extractive liquid; With activated carbon decolorizing, filtration, filtrating promptly gets through being evaporated to paste.
The preparation of embodiment 3 Chinese medicine compositions (III) and extract thereof
Get Radix Polygalae 100g, Herba speranskiae tuberculatae 120g, Herba Artemisiae Scopariae 80g, hair Rhizoma Zingiberis Recens 70g, Radix Adenophorae (Radix Glehniae) 50g, Caulis Hederae Sinensis 100g, pulverize, excessively mix homogeneously behind 40 mesh sieves; The adding mass fraction is 50% ethanol water 4.5kg, and heating and refluxing extraction 120min repeats to extract 2 times; Merge extractive liquid; With activated carbon decolorizing, filtration, filtrating promptly gets through being evaporated to paste.
Embodiment 4 minimal inhibitory concentrations (MIC) test
Get the culture dish that contains different extract concentrations gradients; Draw the corresponding confession examination bacterium of 0.1mL with aseptic straw and be added drop-wise in the above-mentioned culture dish, smoothen, cultivate 24h down at 37 ℃ with aseptic L type Glass rod; Compare the record observed result with sterilized water, blank extracting solution and extract diluent.With the least concentration that does not have thalli growth fully is the MIC of this extract.And with pyrithione zinc as positive control.The test procedure reference [Zheng Jiaqi, Li Jiahong. clinical bacteriology. Beijing: People's Health Publisher, 1986,11-12,367-368].Testing result is seen shown in the table 1.
The MIC of the various bacterium of table 1 (mg/L)
Can find out that by table 1 the Chinese medicine composition extract of the present invention preparation has the good restraining effect to various bacteria such as the Malassezia furfur that can cause the dandruff and escherichia coli and fungus.
Embodiment 5 treatment seborrheic alopecia effect assessment tests
Press the extract of embodiment 3 preparation Chinese medicine compositions (III), be dissolved in 10% the alcoholic solution, be made into 1% Chinese medicine composition extract solution, on probation sample.
Select 20-45 year dandruff patient 40 examples, wherein male 20 people, women 20 people, crowd on probation.
Therapeutic Method: the patient will try out sample and embrocate the affected part gently with absorbent cotton, kowtow gently at the coating place with finger and hit 2min, and morning every day, 7 was a course of treatment, treats 2 courses of treatment continuously with 1 time.Follow up a case by regular visits to record result, drug withdrawal post-evaluation curative effect before and after all patient treatments.
Curative effect determinate standard: recovery from illness (dandruff disappears, no scratchiness); Produce effects (dandruff obviously reduces, and pruritus disappears); Effectively (dandruff reduces, and pruritus alleviates); Invalid (dandruff slightly reduces or no change, and pruritus is slightly clear or the same).Efficacy result is seen shown in the table 2.
Table 2 therapeutic evaluation result
Table 1 is the result show, Chinese medicine composition of the present invention has very obvious effects to the treatment dandruff, and the above ratio of produce effects reaches 87.5%, and effectively above ratio reaches 95%.
Embodiment 6 dandruff control shampoos and preparation method thereof
Table 3 provides the dandruff control shampoo prescription that contains the Chinese medicine extraction compositions, and the consumption of each material is represented with mass fraction.
Table 3 anti-dandruff hair-care shampoo prescription
Anti-dandruff hair-care shampoo method for preparing: deionized water is heated to 80 ℃, adds cation guar gum, after the insulation dissolving evenly, add disodiumedetate, citric acid, sodium chloride, stirring and dissolving.Then, add lauryl alcohol sulfuric ester ammonium and lauryl alcohol polyethenoxy ether sodium sulfovinate, stirring and dissolving.Add pearlescent flake, 16 octadecanol, stirring and dissolving.Add lauric acid amide of ethanol, cocamido propyl betaine and Chinese medicine extraction compositions, stir, feed water quench to 50 ℃, add triumphant loose antiseptic, emulsified silicone oil and essence, when continuing to be cooled to 40 ℃, be the anti-dandruff hair-care shampoo.
Embodiment 7 anti-dandruff sprays and preparation method thereof
Table 3 provides the anti-dandruff spray prescription that contains the Chinese medicine extraction compositions, and the consumption of each material is represented with mass fraction.
Table 3 anti-dandruff is sent out the spray prescription
Anti-dandruff is sent out the spray method for preparing: all the components is dissolved in the deionized water in will filling a prescription, and stirs, and packs into to have in the bottle of shower nozzle, is anti-dandruff and sends out spray.
Claims (3)
1. the Chinese medicine composition with anti-dandruff function is characterized in that by weight percentage, and is composed of the following components:
2. contain the anti-dandruff external agent of the extract of the described Chinese medicine composition of claim 1, it is characterized in that containing in this anti-dandruff external agent the extract of the described Chinese medicine composition of claim 1, its consumption is 0.05-20%.
3. anti-dandruff external agent according to claim 2 is characterized in that: the not special restriction of the dosage form of this anti-dandruff external agent can be solution, emulsion, cream frost shape, spray etc.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101735947A CN102670735A (en) | 2012-05-28 | 2012-05-28 | Anti-dandruff Chinese medicinal composition and application thereof to anti-dandruff external application agent |
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| CN2012101735947A CN102670735A (en) | 2012-05-28 | 2012-05-28 | Anti-dandruff Chinese medicinal composition and application thereof to anti-dandruff external application agent |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751073A (en) * | 2014-02-26 | 2014-04-30 | 广东轻工职业技术学院 | Compound traditional Chinese medicine extract with function of removing dandruff, and application |
| CN104288042A (en) * | 2014-09-30 | 2015-01-21 | 郑通彪 | Anti-dandruff shampoo |
| CN111973641A (en) * | 2013-08-22 | 2020-11-24 | 卢卡斯迈耶化妆品加拿大公司 | Antidandruff compositions and methods of use thereof |
-
2012
- 2012-05-28 CN CN2012101735947A patent/CN102670735A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111973641A (en) * | 2013-08-22 | 2020-11-24 | 卢卡斯迈耶化妆品加拿大公司 | Antidandruff compositions and methods of use thereof |
| CN111973641B (en) * | 2013-08-22 | 2022-12-30 | 卢卡斯迈耶化妆品加拿大公司 | Antidandruff compositions and methods of use thereof |
| CN103751073A (en) * | 2014-02-26 | 2014-04-30 | 广东轻工职业技术学院 | Compound traditional Chinese medicine extract with function of removing dandruff, and application |
| CN103751073B (en) * | 2014-02-26 | 2015-04-22 | 广东轻工职业技术学院 | Compound traditional Chinese medicine extract with function of removing dandruff, and application |
| CN104288042A (en) * | 2014-09-30 | 2015-01-21 | 郑通彪 | Anti-dandruff shampoo |
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Application publication date: 20120919 |