CN104983817A - Tincture for treating seborrheic alopecia and preparation method of tincture - Google Patents
Tincture for treating seborrheic alopecia and preparation method of tincture Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating seborrheic alopecia. The traditional Chinese medicine composition comprises paniculate swallowwort root, chloranthus spicatus, agastache, densefruit pittany root-bark, rosemary, root of hollyhock, vernonia, carthamus tinctorius, seed cowherb, ginseng leaves, sanchi flowers, semen nigellae, fructus psoraleae, black bean, peppermint camphor, borneol and kaoliang spirit. The traditional Chinese medicine composition is in the form of tincture which is formed by conducting extraction on pure traditional Chinese medicine, is fastidious and mild in formula, and simple and easy in preparation, and is mainly used for hair holding, hair regrowing, oil controlling, fat removing, acarus killing, detoxifying, dandruff removing, wind-evil dispelling and itching relieving. The tincture is high in hair regrowth efficiency and lasting in curative effect, and has the advantages that the 'ecological environment' of scalp can be improved synchronously while the purpose of hair regrowth is realized; the symptoms such as greasy scalp, too much dandruff, pruritus, epifolliculitis and seborrheic dermatitis can be treated effectively; the rebound possibilities of the symptoms are low after a user stops taking the traditional Chinese medicine composition; toxic or/and side effects are avoided; the use is safe; the traditional Chinese medicine composition can be used in preparation of medicine for treating seborrheic alopecia.
Description
Technical field
The invention belongs to pharmaceutical field, that one is mainly used in the multiple alopecia symptoms such as treatment seborrheic alopecia, alopecia areata, alopecia generalisata, simultaneously can improve and treat the Chinese herbal medicine for external use tincture that scalp is greasy, consider the symptoms such as many prurituss, folliculitis, seborrheic dermatitis to be worth doing, particularly relate to and a kind ofly treat tincture of seborrheic alopecia and syndrome thereof and preparation method thereof.
Background technology
Everybody has a love of beauty.U.S. is the target that mankind itself constantly pursues forever.Hair, as one of the important symbol of mankind U.S., just enjoys people self to pay close attention to since ancient times.
But along with the development of society, the quickening of people's rhythm of life and the stress from each side, make depilation phenomenon more and more serious and general, and in cumulative year after year and rejuvenation trend.And modal be exactly seborrheic alopecia, also known as " the property alopecia of androgen source ", be commonly called as " getting a bit thin on top ", account for alopecia crowd's about 90%.In China adult, alopecia crowd probability is about 37%, and the white race group National Adult alopecia probability such as some America and Europe are more than 65%, and alopecia problem becomes the puzzlement of a lot of people according to relevant statistics!
For many years, people attempt to treat this " world-famous puzzle " by how various method, comprise medicine and take therapy, external application therapy, surgical operation therapy (comprising hair grafting, scalp flap Transfer etc.) and Chinese physical therapy therapy etc. orally.But because alopecia etiology and pathogenesis is complicated, especially seborrheic alopecia, easily examines and not easily controls, and is listed in for a long time " worldwide difficult disease " always.
Doctor trained in Western medicine commonly uses therapy to be had outside finasteride (protect method only) interior oral administration or minoxidil (Man Di) and puts method on the skin.But these two kinds of Western medicine take effect comparatively slow, and life cycle is longer, and are easy to bounce-back, and its side effect is also obvious.Chinese traditional treatment method is multifarious, varied especially, have for oral administration, put on the skin outward, also the multiple therapy such as acupuncture, massage is had, but treat the checking of the tcm product of seborrheic alopecia according to me to current and investigate, generally lack enough rationales, and hello, and picture all have ignored the application of Chinese medicine " Overall View " and " treatment is basic " theory, have ignored the attention to whole " ecological environment " of hair and improvement, great majority just bias toward the nutritional supplementation of hair or emphasize that hair follicle activates, and therapeutic scheme is more unilateral.So although the product for the treatment of seborrheic alopecia is in the market a feast for the eyes, many shortage rationales and textual criticism, produce effects also very micro-, this " global problem " not yet has breakthrough progress at present.
The composition of tincture of the present invention comes from inventor's medical book handed down from one's ancestors " clear spring side wants " it " close disperse ", and this ancient prescription altogether for fine powder forms, specially controls the alopecia symptom such as " alopecia seborrheica " (i.e. seborrheic alopecia) and " alopecia areata " (i.e. alopecia areata) by tens taste Chinese herbal medicine.Its using method is originally: first wash hair before use, after dry, medicated powder is evenly sprinkling upon alopecia place scalp, then repeatedly rub until scalp heating, use double-edged fine-toothed comb (a kind of toothcomb) by scalp combing repeatedly again, until medicated powder combing is clean, every day one to twice, " three days; white scales does not have again, scalp is not itched again; Seven days, the not multiple oil of scalp, hair does not answer; More than month, fine new life; One hundred days, black hair cloudlike ".But, because modern's life and work rhythm are accelerated, the using method of " close disperse " ancient prescription has inconvenience more, I am through repeatedly to probe into for many years and verify, " close disperse " is modified into the external-use tincture that can directly smear, be suitable for the alopecia symptoms such as seborrheic alopecia (the property alopecia of androgen source), alopecia areata, meanwhile, can the therapeutic effect also highly significant of, the syndrome such as the dandruff increase, scalp itch, folliculitis, seborrheic dermatitis greasy to hair cream.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of seborrheic alopecia, the weight proportion of this Chinese medicine composition is:
Radix Cynanchi Paniculati 3-9 part, chu lan tree 3-9 part, Herba Pogostemonis 3-9 part, Cortex Dictamni 3-9 part, Herba Rosmarini Officinalis 3-9 part, Radix althaeae roseae 3-9 part, Herba Vernonia esculenta 3-9 part, Flos Carthami 3-9 part, Semen Vaccariae 3-9 part, Folium Ginseng 3-9 part, flower of Radix Notoginseng 3-9 part, Semen Nigellae 3-9 part, Fructus Psoraleae 3-9 part, Semen sojae atricolor 3-9 part, Mentholum 1-3 part, Borneolum Syntheticum 1-3 part, jowar wine (alcohol concentration is 40-75 degree) 100-1000 part.
Another object of the present invention is to provide described a kind of preparation method for the treatment of the Chinese medicine composition of seborrheic alopecia, is realized by following steps:
(1) get raw material of Chinese medicine mixing in proportion, make 20 order coarse powder;
(2) getting step (1) raw material of Chinese medicine coarse powder loads in container;
(3) getting jowar wine 100-1000 part slowly pours in the container that raw material of Chinese medicine coarse powder is housed, and limit bevelling stirs, then sealed container;
(4) soak more than seven days under room temperature, every day period fully stirs once, stirs and terminates rear sealed container;
(5) be placed in extraction pot, extract 3 hours at 50-60 DEG C continuously with water bath reflux method, then filter waste, reconcentration, obtain a kind of brown Traditional Chinese medicine tincture preparation.
using method of the present invention:
Get it filled the appropriate uniform application of tincture in alopecia size skin, every day 2-3 time according to alopecia area.
feature of the present invention
Tincture of the present invention is formed by pure Chinese medicine extraction, and formula is fastidious and gentle, makes simple.Main Function
behair strengthening hair growth promoting, controls oily fat eliminating, parasite killing acaricide, and toxin expelling is anti-dandruff, dispelling wind for relieving itching.The hair regrowth instant effect of tincture of the present invention and curative effect is lasting, while hair growth promoting, synchronously can improve " ecological environment " of scalp, effectively treatment scalp greasy, consider the symptoms such as many prurituss, folliculitis, seborrheic dermatitis to be worth doing.
Another object of the present invention is to provide the application of described Chinese medicine composition in the medicine of preparation treatment seborrheic alopecia.Described medicine is Traditional Chinese medicine tincture preparation, and described seborrheic alopecia also comprises its syndrome.
rationale of the present invention
Alopecia etiology and pathogenesis is complicated, alopecia type is various, common are seborrheic alopecia (being called for short " seborrheic alopecia "), is commonly called as " getting a bit thin on top ", account for alopecia crowd's about 90%, its main manifestations is the symptoms such as hair tinyization, scalp and hair are greasy, the dandruff increases, scalp itch.This disease is easily examined and is not easily controlled, and is listed in worldwide difficult disease.
Modern medicine is thought, seborrheic alopecia main with heredity, diet thick greasy pungent, do not have enough sleep, hormone disorder etc. is relevant.Its etiology and pathogenesis is complicated, main alopecia district pathological change is: in alopecia district raw coal bunker and dermal papilla, 5a-reductase level increases, smegma function is vigorous, addicted to fat antibacterial and microbial growth, blood capillary number reduces, the atrophy of hair follicle degeneration, cortex degeneration is thinning, the natural on-off cycles of hair growth cycle shortens gradually, and hair is tinyization gradually, finally causes alopecia.
The traditional Chinese medical science claims seborrheic alopecia to be " sending out moth " or " alopecia seborrheica ", caused by the factors such as its cause of disease is mainly the hepatic and renal YIN deficiency, noxious dampness is stifling, worm demodicid mite moth is invaded, hair key stasis blocking.The traditional Chinese medical science advocates " controlling outer with interior ", and the outer rule for the treatment of is when to moisten, foster fur, dampness fat eliminating, dispelling wind are antipruritic, parasite killing acaricide, tonneau hair key etc.
The present invention selects the Chinese medicines such as Radix Cynanchi Paniculati, chu lan tree, Herba Pogostemonis with dampness fat eliminating, and modern pharmacology confirms, these three kinds of Chinese medicines all have and suppress the effect of smegma, in order to the symptom such as improve scalp and hair is greasy.Select Cortex Dictamni, Herba Rosmarini Officinalis, Radix althaeae roseae, Herba Vernonia esculenta, Borneolum Syntheticum etc. are antipruritic with dispelling wind, it is anti-dandruff to kill demodicid mite, can improve scalp itch, the symptom such as dandruff increases, folliculitis, mite infection.Select Flos Carthami, Semen Vaccariae etc. with promoting the circulation of blood treating blood disorders, disperse blood stasis and dredge collateral, modern pharmacology proves that these two kinds of Chinese medicines can not only promote scalp blood microcirculation, increase scalp capillary network, and there is estrogen-like effects, to resist the androgen around hair follicle root sheath and scalp true nipple, and according to proving that Semen Vaccariae also has the effect suppressing 5a-reductase.Select Folium Ginseng, flower of Radix Notoginseng contain abundant Saponin, flavonoid glycoside, several amino acids and volatilization wet goods composition, give the nutrition that scalp and hair follicle are abundant, have and significantly delay hair follicle cell aging, extend growth cycle of hair, and there is conciliation skin and the multiple efficacies such as hair follicle water, oil balance.Select three kinds of black plant black seeds such as Semen Nigellae, Fructus Psoraleae, Semen sojae atricolor, should with the theory of the traditional Chinese medical science " black enter kidney, send out as China of kidney "; Modern pharmacology also confirms, these three kinds of black medical materials all containing abundant phytoestrogen, effectively to resist hair follicle androgen; Simultaneously containing various trace elements and phytomelanes such as copper, ferrum, selenium, zinc, needed for supplementary hair follicle healthy growth, and still there is effect of supplementary hair follicle melanocyte.Mentholum, jowar wine etc. is selected to have the effects such as sterilization and anticorrosion, tonneau hair key, short Transdermal absorption.All medicines are collaborative above makes a concerted effort, and plays hair strengthening hair growth promoting altogether, controls oily fat eliminating, parasite killing acaricide, the effect of removing scurf and relieving itching.
Pharmaceutical composition of the present invention have solid in, doctor trained in Western medicine about the theories integration of alopecia pathology and disease mechanism, reasonable mixture ratio of components; Hair growth of the present invention is realized by number of ways, therefore quick result and lasting, not easily rebounds after drug withdrawal; Tincture of the present invention, while hair strengthening hair growth promoting, synchronously can improve " ecological environment " of hair, effectively treats the attendant symptoms that scalp is greasy, consider the seborrheic alopecia such as many prurituss, folliculitis, seborrheic dermatitis to be worth doing.Pharmaceutical composition clinical efficacy of the present invention is definite, and has no side effect, use safety.
Detailed description of the invention
The present invention is further described in conjunction with the embodiments.
embodiment 1
A kind of Chinese medicine composition and weight proportion thereof for the treatment of seborrheic alopecia of the present invention:
Radix Cynanchi Paniculati 3 parts, chu lan tree 3 parts, Herba Pogostemonis 3 parts, Cortex Dictamni 3 parts, Herba Rosmarini Officinalis 3 parts, Radix althaeae roseae 3 parts, Herba Vernonia esculenta 3 parts, 6 parts, Flos Carthami, Semen Vaccariae 6 parts, Folium Ginseng 3 parts, flower of Radix Notoginseng 3 parts, Semen Nigellae 3 parts, Fructus Psoraleae 3 parts, 3 parts, Semen sojae atricolor, Mentholum 0.5 part, Borneolum Syntheticum 1 part, jowar wine (alcohol concentration is 40-75 degree) 100-1000 part.
The preparation method of described Chinese medicine composition, is realized by following steps:
(1) get raw material of Chinese medicine mixing in proportion, make 20 order coarse powder altogether;
(2) getting step (1) raw material of Chinese medicine coarse powder loads in container;
(3) getting jowar wine 100-1000 part slowly pours in the container that raw material of Chinese medicine coarse powder is housed, and limit bevelling stirs, then sealed container;
(4) soak more than seven days under room temperature, every day period fully stirs once, stirs and terminates rear sealed container;
(5) be placed in extraction pot, extract 3 hours continuously with " water bath reflux method " at middle temperature 50-60 DEG C, then filter waste, reconcentration obtains a kind of brown Traditional Chinese medicine tincture preparation.
using method of the present invention:
Get it filled the appropriate uniform application of tincture in alopecia size skin, every day 2-3 time according to alopecia area.
embodiment 2
A kind of Chinese medicine composition and weight proportion thereof for the treatment of seborrheic alopecia and syndrome thereof:
Radix Cynanchi Paniculati 5 parts, chu lan tree 5 parts, Herba Pogostemonis 5 parts, Cortex Dictamni 3 parts, Herba Rosmarini Officinalis 5 parts, Radix althaeae roseae 5 parts, Herba Vernonia esculenta 5 parts, 5 parts, Flos Carthami, Semen Vaccariae 5 parts, Folium Ginseng 3 parts, flower of Radix Notoginseng 3 parts, Semen Nigellae 5 parts, Fructus Psoraleae 5 parts, 5 parts, Semen sojae atricolor, Mentholum 0.3 part, Borneolum Syntheticum 0.5 part, jowar wine (alcohol concentration is 40-75 degree) 100-1000 part.
The preparation method of described Chinese medicine composition is with embodiment 1.
Using method is with embodiment 1.
embodiment 3
A kind of Chinese medicine composition and weight proportion thereof for the treatment of seborrheic alopecia and syndrome thereof:
Radix Cynanchi Paniculati 6 parts, chu lan tree 6 parts, Herba Pogostemonis 6 parts, Cortex Dictamni 3 parts, Herba Rosmarini Officinalis 3 parts, Radix althaeae roseae 3 parts, Herba Vernonia esculenta 3 parts, 3 parts, Flos Carthami, Semen Vaccariae 3 parts, Folium Ginseng 3 parts, flower of Radix Notoginseng 3 parts, Semen Nigellae 3 parts, Fructus Psoraleae 3 parts, 3 parts, Semen sojae atricolor, Mentholum 0.2 part, Borneolum Syntheticum 0.5 part, jowar wine (alcohol concentration is 40-75 degree) 100-1000 part.
The preparation method of described Chinese medicine composition is with embodiment 1.
Using method of the present invention is with embodiment 1.
embodiment 4
A kind of Chinese medicine composition and weight proportion thereof for the treatment of seborrheic alopecia and syndrome thereof:
Radix Cynanchi Paniculati 9 parts, chu lan tree 9 parts, Herba Pogostemonis 9 parts, Cortex Dictamni 3 parts, Herba Rosmarini Officinalis 3 parts, Radix althaeae roseae 3 parts, Herba Vernonia esculenta 3 parts, 5 parts, Flos Carthami, Semen Vaccariae 5 parts, Folium Ginseng 3 parts, flower of Radix Notoginseng 3 parts, Semen Nigellae 5 parts, Fructus Psoraleae 5 parts, 5 parts, Semen sojae atricolor, Mentholum 0.2 part, Borneolum Syntheticum 0.5 part, jowar wine (alcohol concentration is 40-75 degree) 100-1000 part.
The preparation method of described Chinese medicine composition is with embodiment 1.
Using method is with embodiment 1.
embodiment 5
Observe finasteride (protect method only) treatment seborrheic alopecia 6 example, when wherein 4 people use six months continuously, alopecia symptom is controlled substantially, has a small amount of tiny fine hair to occur; Wherein 2 people use more than 12 continuously, before after drug withdrawal, in 4 weeks, treatment is arrived in basic bounce-back.Sum up finasteride effect major embodiment and control alopecia symptom, and hair-growing effects is relatively slower, effect " equivocal ".Its side effect is mainly manifested in male's sexual and goes down in various degree.
embodiment 6
Observe 5% minoxidil treatment seborrheic alopecia (Man Di) 7 example, wherein 4 people hair-growing effects when treatment 8 weeks is obvious, there is obvious hair-growing effects when treatment 10 weeks in 3 people, but 7 people all when treatment 12 weeks alopecia amount increase suddenly, 15-16 almost all made it back during week; Continue medication to continue again after 8 weeks to occur comparatively significantly hair-growing effects, but drug withdrawal follows up a case by regular visits to 4 weeks, in succession starts again to occur alopecia.Sum up the curative effect that minoxidil is used for the treatment of alopecia to mostly occur 2 ~ 3 months treatment initial stages.Analyze this mainly due to minoxidil external curing seborrheic alopecia, be merely able to impel the hair growth number of microminiaturization to increase severely, but the growth cycle of alopecia can not be extended.The side reaction of minoxidil external, mainly irritative response, namely there is drying, desquamation, to itch and rubescent in application site.Life-time service can cause hirsutism in addition.
embodiment 7
Tracing observation alopecia person totally 275 examples over nearly 20 years, wherein:
(1) observe seborrheic alopecia patient totally 249 examples, use Traditional Chinese medicine tincture preparation of the present invention, with 6 months for the observation period, point
Be three criterions: cure (basic recovery is normal), effective (hair showed increased, hair can hide scalp completely), effective (have obvious visual effect, but hair hiding scalp not yet completely).Observed result is as follows:
Slight de-originator 106 example, cures 98 examples, effective 8 examples, effective percentage 100%; Moderate takes off originator 115 example, basic healing 96 example, effective 18 examples, effective 1 example, effective percentage 100%; Severe takes off originator 28 example, cures 0 example, effective 20 examples, effective 8 examples, effective percentage 100%.The greasy scalp attendant symptoms that waits of all de-originator scalps all disappeared at 7-15 days, and alopecia attendant symptoms cure rate is 100%.
(2) observe patients with alopecia areata totally 26 examples, use Traditional Chinese medicine tincture preparation of the present invention, with six months for the observation period: wherein cure 24 examples, effective 1 example (for alopecia totalis patient), invalid 1 example (stopping external tincture of the present invention because of alcohol intolerance), effective percentage 96%.
Hair growth of the present invention is realized by number of ways, general use within 3-7 days, can obviously improve scalp greasy, consider the symptoms such as many prurituss to be worth doing; Use within 7-15 days, can obviously improve or cure the symptom such as folliculitis, seborrheic dermatitis; Use month visible new sending out to regenerate, originally soft hair is more sturdy; Namely can see after using three months and significantly visually improving.In the de-originator of above 275 example, except a routine alcohol intolerance, do not find other toxic and side effects.
The foregoing is only section Example of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (4)
1. treat a Chinese medicine composition for seborrheic alopecia, it is characterized in that, the composition of this Chinese medicine composition and weight proportion are:
Radix Cynanchi Paniculati 3-9 part, chu lan tree 3-9 part, Herba Pogostemonis 3-9 part, Cortex Dictamni 3-9 part, Herba Rosmarini Officinalis 3-9 part, Radix althaeae roseae 3-9 part, Herba Vernonia esculenta 3-9 part, Flos Carthami 3-9 part, Semen Vaccariae 3-9 part, Folium Ginseng 3-9 part, flower of Radix Notoginseng 3-9 part, Semen Nigellae 3-9 part, Fructus Psoraleae 3-9 part, Semen sojae atricolor 3-9 part, Mentholum 1-3 part, Borneolum Syntheticum 1-3 part, 40-70 degree jowar wine 100-1000 part.
2. a kind of preparation method for the treatment of the Chinese medicine composition of seborrheic alopecia according to claim 1, be is characterized in that, realized by following steps:
(1) get raw material of Chinese medicine mixing in proportion, make 20 order coarse powder;
(2) getting step (1) raw material of Chinese medicine coarse powder loads in container;
(3) getting jowar wine 100-1000 part slowly pours in the container that raw material of Chinese medicine coarse powder is housed, and limit bevelling stirs, then sealed container;
(4) soak more than seven days under room temperature, every day period fully stirs once, stirs and terminates rear sealed container;
(5) be placed in extraction pot, extract 3 hours at 50-60 DEG C continuously with water bath reflux method, then filter waste, reconcentration, obtain a kind of brown Traditional Chinese medicine tincture preparation.
3. the application of Chinese medicine composition according to claim 1 in the medicine of preparation treatment seborrheic alopecia.
4. application according to claim 3, is characterized in that, described medicine is Traditional Chinese medicine tincture preparation, and described seborrheic alopecia comprises its syndrome.
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| CN105434727A (en) * | 2015-12-29 | 2016-03-30 | 青岛昌安达药业有限公司 | Traditional Chinese medicine preparation for treating neurodermatitis |
| CN109793696A (en) * | 2019-03-22 | 2019-05-24 | 广州韩金靓化妆品有限公司 | A kind of anti-dandruff plant composition and its preparation method and application |
| CN115337351A (en) * | 2022-06-10 | 2022-11-15 | 浙江工业大学 | Traditional Chinese medicine compound essential oil |
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| CN1706437A (en) * | 2005-05-27 | 2005-12-14 | 王家军 | Combined Chinese and Western medicine liniment for treating seborrheic baldness |
| CN101181362A (en) * | 2007-11-28 | 2008-05-21 | 汤家英 | Chinese medicine exterior wiping preparations for growing and blacking hair |
| CN101254274A (en) * | 2008-03-27 | 2008-09-03 | 李洪元 | Nano chinese medicinal composition for curing white hair alopecia and preparation |
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| CN1706437A (en) * | 2005-05-27 | 2005-12-14 | 王家军 | Combined Chinese and Western medicine liniment for treating seborrheic baldness |
| CN101181362A (en) * | 2007-11-28 | 2008-05-21 | 汤家英 | Chinese medicine exterior wiping preparations for growing and blacking hair |
| CN101254274A (en) * | 2008-03-27 | 2008-09-03 | 李洪元 | Nano chinese medicinal composition for curing white hair alopecia and preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105434727A (en) * | 2015-12-29 | 2016-03-30 | 青岛昌安达药业有限公司 | Traditional Chinese medicine preparation for treating neurodermatitis |
| CN109793696A (en) * | 2019-03-22 | 2019-05-24 | 广州韩金靓化妆品有限公司 | A kind of anti-dandruff plant composition and its preparation method and application |
| CN115337351A (en) * | 2022-06-10 | 2022-11-15 | 浙江工业大学 | Traditional Chinese medicine compound essential oil |
| CN115337351B (en) * | 2022-06-10 | 2024-01-30 | 广州古茶匠生物科技有限公司 | Traditional Chinese medicine compound essential oil |
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