CN105596742B - A topical Chinese medicinal ointment for treating burn and scald, and its preparation method - Google Patents

A topical Chinese medicinal ointment for treating burn and scald, and its preparation method Download PDF

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CN105596742B
CN105596742B CN201511033470.9A CN201511033470A CN105596742B CN 105596742 B CN105596742 B CN 105596742B CN 201511033470 A CN201511033470 A CN 201511033470A CN 105596742 B CN105596742 B CN 105596742B
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chinese medicine
burn
oil
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CN105596742A (en
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周汉功
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739Sanguisorba (burnet)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses an external traditional Chinese medicine ointment for treating burns and scalds and a preparation method thereof, wherein the ointment is composed of raw materials and auxiliary materials, wherein the raw materials are composed of the following traditional Chinese medicine components in parts by weight: 40-60 parts of catechu, 40-60 parts of bletilla striata, 40-60 parts of garden burnet, 80-120 parts of scutellaria baicalensis, 80-120 parts of pubescent holly root, 4-6 parts of borneol and 750-850 parts of chicken oil. The invention is a folk prescription based on the theory of traditional Chinese medicine, has the efficacies of clearing away heat and toxic material, astringing and relieving pain, and detumescence and promoting granulation, can effectively relieve burn pain, and promotes wound healing and regeneration, and has simple preparation process, low production cost and convenient use. Has obvious clinical curative effect on I-degree burn and superficial II-degree burn and scald (boiled water scald, fire burn, electric burn, drug irritation, etc.).

Description

A topical Chinese medicinal ointment for treating burn and scald, and its preparation method
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an external traditional Chinese medicine ointment for treating burns and scalds and a preparation method thereof.
Background
Burn and scald are common diseases in daily life, and are extremely complex traumatic diseases caused by the action of a plurality of factors such as physics, chemistry, radioactive rays and the like on the body. China has no complete statistical report on the incidence probability, treatment method and the like, and 0.5-1% of people suffer from the injury every year. At present, the research work of preventing and treating the burn in China is greatly developed, but the research work is far from the advanced level in the world, and the big sample statistics shows that the death rate of burn patients in China is still maintained at 2.25-5.41%.
At present, external medicines for treating burns and scalds are various, patch and tincture medicines with the functions of diminishing inflammation, relieving pain and promoting tissue regeneration are generally used, main components of western medicines are more, the western medicines generally contain antibiotic components, even if the external medicines are treated by injection and surgical operation, the external medicines have the advantages of high treatment cost, long period and a plurality of defects in the aspects of effectiveness, safety, convenience and the like.
In China, the burn of Chinese medicine has a long research history and accumulates abundant experience. The traditional Chinese medicine theory considers that burn is caused by invasion of fire toxin into human body, fire heat damages yin, causes imbalance of yin and yang, damages viscera, and has toxin-accumulating slough. The traditional Chinese medicine treatment is based on the principles of clearing heat, nourishing yin, detoxifying, astringing, relieving pain, removing necrotic tissue and promoting granulation. As early as in the jin dynasty, ancient books record that the external traditional Chinese medicine prescription for treating burns and scalds is prepared from lard, and later south-aligned ancient books and Ming dynasty records that the traditional Chinese medicine preparation for treating burns and scalds is prepared from traditional Chinese medicines such as golden cypress, coptis chinensis, scutellaria baicalensis, borneol, radix angelicae, gardenia jasminoides, rheum officinale, fructus forsythiae, liquorice and the like.
In order to overcome the defects of western medicines, patent No. cn201310173189.x is prepared by drying and crushing giant knotweed rhizome, garden burnet root and baical skullcap root, decocting, purifying by distillation, adding snake oil, borneol and musk, decocting, and decocting to obtain a Chinese medicinal preparation for treating burns and scalds, cold wounds, diabetic feet, eye cornea burns, inhalation lung injuries, bedsores and other diseases. Although the invention has certain treatment effect on burns and scalds, the invention has the following defects: the snake oil is adopted as an oil agent, the adopted snake oil is not subjected to pickling treatment, the snake oil is used as an oil agent auxiliary material, and the preparation obtained by the invention cannot be attached to a sore for a long time, so that the sore is not healed in time.
In patent CN201310022028.0, cortex albiziae, radix sanguisorbae, radix angelicae sinensis, pedicellus cucurbitae, gypsum and chicken fat are used as raw materials to prepare a paste. The invention has the following defects: the invention mixes the chicken oil and the ground gypsum powder, and the final product has the advantages of hard paste, difficult push-open, easy tearing of the sore, reduced air permeability and easy ulceration of the sore. Meanwhile, the chicken oil in the invention is not subjected to pretreatment such as pickling and water steaming, the oil components are mixed and disordered, the glyceride is more harmful to human blood vessels, the saturated fatty acid is more contained, and the effective components of the traditional Chinese medicine decoction pieces are not easy to be dissolved in the chicken oil, so that the traditional Chinese medicine components of the final preparation are greatly reduced.
In conclusion, how to provide a traditional Chinese medicine ointment with good effects of relieving pain and swelling, fast wound healing and dampness astringing and strong medicine synergistic effect for treating burns and scalds is a technical problem which needs to be solved urgently by people in the field.
Disclosure of Invention
The invention aims to provide an external traditional Chinese medicine ointment for treating burns and scalds, which is a folk prescription based on the theory of traditional Chinese medicine, is reasonably compatible under the guidance of the theory of modern traditional Chinese medicine, has the effects of clearing heat and removing toxicity, astringing and relieving pain, and reducing swelling and promoting granulation, can be firmly adhered to skin, has quick drug effect penetration, effectively relieves burn pain, promotes wound healing and regeneration, prevents scars, and has the advantages of simple prescription, simple preparation process, low production cost and convenient use.
Therefore, the invention adopts the following technical scheme:
a traditional Chinese medicine ointment for external use for treating burns and scalds consists of raw materials and auxiliary materials, wherein the raw materials consist of the following traditional Chinese medicine components in parts by weight: 40-60 parts of catechu, 40-60 parts of bletilla striata, 40-60 parts of garden burnet, 80-120 parts of scutellaria baicalensis, 80-120 parts of pubescent holly root, 4-6 parts of borneol and 750-850 parts of chicken oil.
Preferably, the raw materials comprise the following traditional Chinese medicine components in parts by weight: 50 parts of catechu, 50 parts of bletilla striata, 50 parts of garden burnet, 100 parts of scutellaria baicalensis, 100 parts of pubescent holly root, 5 parts of borneol and 800 parts of chicken oil.
Preferably, the chicken oil in the raw materials is pretreated oil, and the pretreatment method comprises the following steps: salting fresh chicken oil, steaming in water, and collecting upper layer oil.
The invention also provides a preparation method of the external traditional Chinese medicine ointment for treating burns and scalds, which comprises the following steps: (1) mixing and feeding decoction pieces containing bletilla striata, garden burnet, scutellaria baicalensis and pubescent holly root according to the formula amount, adding 10-15 times of water by weight, heating, refluxing and extracting for 2-3 times, extracting for 1-2 hours each time, filtering, combining and concentrating until the relative density is about 1.20-1.30, and performing spray drying to obtain an extract for later use; (2) adding a proper amount of salt into fresh chicken oil according to the formula amount by weight, pickling for 2-3 days, steaming for 2-3 hours in a water-proof manner, completely melting the chicken oil, and taking upper-layer grease for later use; (3) adding a proper amount of ethylparaben, vaseline and beeswax into the grease obtained in the step (2), heating to 70 ℃, melting and stirring uniformly, and cooling to room temperature; and (2) adding the extract obtained in the step (1) and the catechu and borneol in the prescription amount, uniformly stirring, finely filtering, filling and sealing to obtain the external traditional Chinese medicine ointment.
Preferably, in the step (1), the water addition amount is 12 times, the reflux extraction times are 2 times, the extraction time is 1 hour each time, and the relative density of the concentrated liquid is about 1.25.
Preferably, in the step (2), the chicken oil is pickled for 2 days and steamed for 2.5 hours in a water-proof way.
Preferably, in the step (3), the catechu is added in a powder form.
The raw material effects and the pharmacological activity of the traditional Chinese medicine components of the invention are as follows:
chicken oil: the chicken fat (namely the upper layer fat) is prepared by salting and steaming in a water-proof way, contains various high-grade unsaturated fatty acids, is less greasy, and has the effects of healing sore, astringing dampness, reducing swelling and lubricating. Is used for closing the superficial skin trauma wound, repairing the skin, preventing scar and protecting and softening the skin tissue. Compared with the chicken fat which is not pretreated, the chicken fat pretreated by the method has better antibacterial effect and can be stored for a long time.
Catechu: is dried soft extract of peeled branch and dried of Acacia catechu (L.f.) Willci of Leguminosae. Collecting branches and trunks in winter, removing the outer skin, cutting into large blocks, adding water, decocting, concentrating, and drying. Has the effects of promoting blood circulation, relieving pain, stopping bleeding, promoting granulation, astringing dampness, promoting wound healing, clearing lung-heat and eliminating phlegm. Can be used for treating traumatic injury, traumatic hemorrhage, hematemesis, epistaxis, unhealing pyocutaneous disease, eczema, and cough due to lung heat.
Bletilla striata: is a dried tuber of the plant Bletilla striata (Thunb.) reichb.f. of the family Orchidaceae. Bletilla striata has wide medicinal value and garden value. It is mainly used for astringing to stop bleeding, eliminating swelling and promoting granulation.
Garden burnet root: latin learning name: sanguisorba officinalis L, a perennial herb of the genus Ulmus of the family Rosaceae. Cold in nature, bitter in acid and non-toxic; it enters liver, lung, kidney and large intestine meridians. Has the effects of cooling blood, stopping bleeding, clearing away heat and toxic materials, nourishing yin, relieving swelling and healing wound.
Scutellaria baicalensis: latin learning name: scutellaria basilica Georgi, also known as root of Camellia japonica or root of Thymelaeaceae, is a perennial herb of the genus Scutellaria of the family Labiatae. The root of scutellaria is bitter in taste and cold in nature, and has the effects of clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding, preventing miscarriage and the like. It can be used for treating epidemic febrile disease, upper respiratory infection, cough due to lung heat, yellow gallbladder due to damp-heat, pneumonia, dysentery, hemoptysis, conjunctival congestion, threatened abortion, hypertension, carbuncle, furuncle, and sore. The clinical antibacterial property of scutellaria is better than that of coptis, and the scutellaria does not produce drug resistance.
Pubescent holly root: the name learning: ilex pubescens, a plant of the genus Ilex of the family Aquifoliaceae. Mainly used for clearing away heat and toxic material; promoting blood circulation and removing obstruction in channels. Mainly treating wind-heat type common cold; cough and asthma due to lung heat; sore throat; a latex moth; swelling and aching of gum; chest stuffiness and pain; stroke hemiplegia; thromboangiitis obliterans; erysipelas; burns and scalds; carbuncle and deep-rooted carbuncle; central retinitis. Preliminary bacteriostatic tests show that staphylococcus aureus is extremely sensitive to pubescent holly root; bacillus pyocyaneus is also sensitive to deformity, dysentery and pyocyanea.
Borneol: also called borneol, orange slice, blumea balsamifera, borneol, tomatillo castanoca, borneol, plum ice, etc., is prepared from stems and leaves of blumea balsamifera of Compositae or branches and leaves of camphor of Lauraceae through steam distillation and recrystallization. It can be used for treating block pattern of coma, conjunctival congestion with swelling and pain, pharyngitis, aphtha, sore and ulcer with swelling and pain, and unhealed ulcer.
In a word, the chicken fat is used as a monarch drug in the formula, so that the chicken fat has good effects of healing sore, astringing dampness, reducing swelling and lubricating; the four traditional Chinese medicines of bletilla striata, garden burnet, scutellaria baicalensis and pubescent holly root are taken as ministerial medicines, so that the traditional Chinese medicine has good effects of clearing heat and removing toxicity, inhibiting bacteria and diminishing inflammation; catechu is added as adjuvant drug, and has effects of astringing sore, promoting granulation and relieving itching; borneol is a guiding drug, and is cool and bacteriostatic. The ointment prepared by the synergistic effect of the components has golden appearance and color, can be stored for a long time and has good clinical curative effect.
The external traditional Chinese medicine ointment for treating burns and scalds provided by the invention has the following beneficial effects:
1. the adopted chicken oil is the grease obtained by pickling fresh chicken oil and steaming in a water-proof way, and after pretreatment, glyceride components harmful to human blood vessels are discarded, and more glyceride components which do not contain fatty acid are left; compared with common vegetable oil and other animal oil (such as snake oil and lard oil), the chicken oil has higher oleic acid content and stearic acid content, and has the effects of accelerating wound closure, softening skin tissue and preventing scar.
Oleic acid, a monounsaturated Omega-9 fatty acid, is present in animals and plants, has a certain effect of softening phospholipid layers (such as blood vessel walls, skin, etc.), and can promote metabolism of human and animals. The oleic acid content in the chicken oil is relatively high, the diffusion coefficient and activity coefficient of the medicine can be improved, the transdermal speed of the medicine is increased, the medicine is not easy to accumulate at the sore, the medicine absorption by human bodies is facilitated, and the healing acceleration effect on the superficial burn and scald sore is particularly realized.
Stearic acid is widely present in the natural world, and almost all fats and oils contain various amounts of stearic acid, and the content thereof in animal fat is high, and it is a white or off-white powder or crystalline hard block having a greasy feeling in a natural state. Stearic acid has an emulsifying effect in common pasty and milky products (such as medicinal ointment, cosmetics and the like), so that the products become stable white paste. The chicken oil contains higher stearic acid content, so that the paste is easier to reach a stable state in the paste preparation process, is not easy to disperse and flow in a high-temperature environment (such as summer), and is easier to attach to the sore.
2. Clinical tests prove that the external traditional Chinese medicine ointment provided by the invention is reasonable in compatibility, the components of all the components are synergistic, the external traditional Chinese medicine ointment has the effects of reducing swelling, stopping bleeding, astringing dampness, expelling pus, healing sore and removing scars on superficial skin burns and scalds, particularly on I-degree burns and superficial II-degree burns and scalds, the effect of reducing pain can be achieved within a few seconds, and the red swelling can be removed within half a day after the external traditional Chinese medicine ointment is used most quickly.
3. The preparation process provided by the invention adopts fresh chicken oil, is convenient to obtain and has low cost. After the chicken oil is pickled and steamed by water, the chicken oil is pure in components, does not contain glyceride, contains more higher unsaturated fatty acid, and can effectively dissolve active ingredients in other traditional Chinese medicines. Meanwhile, the burn and scald traditional Chinese medicine ointment prepared by the invention has long storage time and better economic value.
Detailed Description
The following examples are presented to further illustrate and describe the present invention, but are not meant to limit the invention thereto.
Example 1:
the formula is as follows: according to the weight portion, 800 portions of chicken oil, 50 portions of bletilla striata, 50 portions of sanguisorba, 100 portions of scutellaria baicalensis, 100 portions of pubescent holly root, 50 portions of catechu and 5 portions of borneol.
The preparation steps are as follows: weighing decoction pieces of rhizoma Bletillae, radix Sangusorbae, Scutellariae radix, and radix Ilicis Pubescentis according to formula ratio, mixing, adding 12 times of water, heating, reflux-extracting for 2 times (each time for 1 hr), filtering, mixing, concentrating to relative density of 1.25, and spray drying to obtain extract; adding a proper amount of salt into 800 parts of fresh chicken oil, pickling for 2 days, steaming for 2.5 hours in a water-proof manner, completely melting the chicken oil, and taking upper-layer oil for later use; adding appropriate amount of ethylparaben, vaseline and Cera flava into the above oil, heating to 70 deg.C, melting, stirring, and cooling to room temperature; adding the extract, 50 parts of catechu (powder) and 5 parts of borneol, stirring uniformly, fine filtering, filling and sealing to obtain the external traditional Chinese medicine ointment.
Example 2:
the formula is as follows: 750 parts of chicken oil, 40 parts of bletilla striata, 40 parts of garden burnet root, 80 parts of scutellaria baicalensis, 80 parts of pubescent holly root, 40 parts of catechu and 4 parts of borneol.
The preparation steps are as follows: weighing decoction pieces of rhizoma Bletillae, radix Sangusorbae, Scutellariae radix, and radix Ilicis Pubescentis according to formula ratio, mixing, adding 10 times of water, heating, reflux-extracting for 2 times (each for 1 hr), filtering, mixing, concentrating to relative density of 1.20, and spray drying to obtain extract; adding a proper amount of salt into fresh chicken oil, pickling for 2 days, steaming for 2 hours in a water-proof way, completely melting the chicken oil, and taking upper-layer oil for later use; adding appropriate amount of ethylparaben, vaseline and Cera flava into the above oil, heating to 70 deg.C, melting, stirring, and cooling to room temperature; adding the extract, catechu (powder) and borneol, stirring uniformly, fine filtering, filling and sealing to obtain the external traditional Chinese medicine ointment.
Example 3:
the formula is as follows: 850 parts of chicken oil, 60 parts of bletilla striata, 60 parts of garden burnet root, 120 parts of scutellaria baicalensis, 120 parts of pubescent holly root, 60 parts of catechu and 6 parts of borneol.
The preparation steps are as follows: weighing decoction pieces of rhizoma Bletillae, radix Sangusorbae, Scutellariae radix, and radix Ilicis Pubescentis according to formula ratio, mixing, adding 15 times of water, heating, reflux-extracting for 3 times (2 hr each time), filtering, mixing, concentrating to relative density of 1.30, and spray drying to obtain extract; adding a proper amount of salt into fresh chicken oil, pickling for 3 days, steaming for 3 hours in a water-proof way, completely melting the chicken oil, and taking upper-layer oil for later use; adding appropriate amount of ethylparaben, vaseline and Cera flava into the above oil, heating to 70 deg.C, melting, stirring, and cooling to room temperature; adding the extract, catechu (powder) and borneol, stirring uniformly, fine filtering, filling and sealing to obtain the external traditional Chinese medicine ointment.
Example 4: clinical efficacy study
The scheme is as follows: patients with clinical burns and scalds of I degree, II degree (including shallow/deep degree) and III degree (including boiled water scald, fire burn, electric burn, chemical burn and the like) are selected. Treatment groups were as follows:
observation group: 45 cases, externally applying the traditional Chinese medicine ointment prepared by the invention;
control group a: 20 cases of external snake oil burn ointment (snake oil, giant knotweed rhizome, borneol, sanguisorba, baical skullcap root and musk in a prescription, namely the technical scheme of the patent CN201310173189. X);
control group B: 20 cases of external-use adeps Sus Domestica paste (prescription adeps Sus Domestica, cortex Salicis Babylonicae Radicis, calx);
control group C: 20 cases of topical wet burn cream (prescription: Coptidis rhizoma, cortex Phellodendri, Scutellariae radix, Lumbricus, and plantula Papaveris);
control group D: vaseline was externally applied to 20 cases.
The administration scheme is as follows: each group is renewed every 4-6 hours, and the medicine and liquefied substance remained on the wound surface are wiped off before the dressing change, so that the wound surface is exposed for medication. For large-scale blister with intolerable distending pain and difficulty in self-absorption, sterilizing, collecting blister liquid, and externally applying ointment. After two consecutive weeks of administration for each group, the efficacy was observed and the mean time to the significant reduction or disappearance of the pain sensation (mean time to onset) was recorded.
The treatment results are as follows:
and (3) burn of I degree: the average onset time of an observation group is shortest; the control group B contains lime, so the ointment is hard, and the skin is pulled when the ointment is applied to a sore, and the onset time is obviously prolonged; the control group C and the group D have no chicken fat effect, and the onset time is far longer than that of the observation group. The total effective rate of the observed group is 100%, the recovery rate is 94.44%, the total effective rate of the control group A is 87.50%, and the recovery rate is 75.00%; the total effective rate of the control B, C, D group was 62.50%, 75.00% and 12.50%, respectively. The onset time, total effective rate and cure rate of the observation group are significantly different from those of the four groups of controls (P is less than 0.01).
II degree burn: the average effect time of an observation group is shortest, the total effective rate is 93.33%, and the cure rate is 80.00%; the total effective rate of the control group A is 83.33 percent, and the cure rate is 16.67 percent; the total effective rates of the control B, C, D three groups were 66.67%, and 33.33%, respectively. The total effective rate and cure rate of the observation groups are obviously different from each group (P is less than 0.01).
And (3) III degree burn: the degree of this burn is severe, and some patients have injured nerves and cannot perceive the sensation of pain, so the onset time cannot be recorded. Under the burn degree, 5 groups of medicines are not cured, the effective rates of an observation group and each control group are close, and no significant difference exists.
Typical cases are:
1. when a woman burns the skin of the thigh part due to the fact that the hot water bag is broken and leaks water, the skin of the thigh part is scalded, the red and swollen area is the whole thigh part, no water bubbles exist, the skin is diagnosed as superficial II degree burn, exposure and moistening therapy is adopted, self-repairing is carried out without skin grafting, the beneficial effect is achieved after the hot water bag is used for treating the burn for 1 day, and the burn is healed after 5 days.
2. If a woman needs to be treated, the water drops splash to the back of the right hand when the boiled water is poured, a small range of scald erythema is generated, the plot is light, and the burn of degree I is diagnosed. After the ointment is used, the pain of the patient is immediately relieved, and the erythema disappears after the ointment is smeared for two times within 10 hours and is cured.
3. Jia somewhere, man, scald the index finger when smoking carelessly, and produce a small range of scald erythema. The pain feeling disappears immediately after the medicine is used immediately, and the erythema disappears after the medicine is smeared once, so that the disease is cured.
4. If a male touches his hand on the metal hot water pipe carelessly in a boiler heating plant, the palm of the hand is scalded, the area of the erythema is large, a plurality of bubbles exist, the skin is not broken, and the scald of shallow II degrees is diagnosed. When the Chinese medicinal composition is directly applied to the surfaces of the blisters and the erythema without treating the blisters for a while, the pain of a patient is relieved after the patient feels self for 3s, the erythema is removed after the patient is applied for three times in one day, the blisters shrink dry after the patient is used for 3 days, and the patients are healed after 8 days without scars.
5. In Wangzhi, men are exposed to sunlight to cause sunburn, the back of the men is red and swollen, and the patients describe that they have been sunburned to produce blisters and then get dry when they come into the hospital, but leave a layer of dead skin with dark color. After the invention is used for 1 day, the red swelling subsides, and after the invention is used for 3 days, the dead skin fades without leaving scars.
6. Wu and women carelessly sprinkle concentrated sulfuric acid to the right lower leg due to self operation, adopt NaOH solution to wash the right lower leg immediately, and then use clear water to wash the right lower leg, but still leave a burn trace with darker color on the right lower leg, and the pain feeling is not disappeared all the time, so the diagnosis is light II degree burn. The invention is directly applied to the splashing part, the pain of a patient is relieved, the color of the burnt part is gradually lightened after the patient uses the ointment for 4 days, and the color difference between the part and the undamaged part is not observable by naked eyes after 9 days.
7. After the high-temperature steam health care of eyes of a certain forest and a woman, the self-induced eyes and eyes of the woman are difficult to endure, and the eyes of the patient are red and swollen and are scalded at the I degree without water bubbles after inspection. When the eye cream is applied to the periphery of eyes, the pain of a patient disappears immediately, and the red swelling condition of the eyes disappears after 3 days of use, so that the eye cream is cured.
And (4) test conclusion: clinical tests prove that the externally applied traditional Chinese medicine ointment prepared by the invention has obvious effect of treating burns and scalds, especially has obvious effect on I-degree and shallow II-degree burns, and has quick response and short cure time. Tests prove that the traditional Chinese medicine composition has the effects of quickly diminishing swelling and relieving pain and short curing time on I degrees and shallow II degrees, and has the effects of diminishing swelling and stopping bleeding, astringing dampness and expelling pus, healing sore and removing scars.
TABLE 1 results of clinical trials
Figure BDA0000899240390000071

Claims (1)

1. A traditional Chinese medicine ointment for external use for treating burns and scalds consists of raw materials and auxiliary materials, wherein the raw materials consist of the following traditional Chinese medicine components in parts by weight: 50 parts of catechu, 50 parts of bletilla striata, 50 parts of sanguisorba officinalis, 100 parts of scutellaria baicalensis, 100 parts of pubescent holly root, 5 parts of borneol and 800 parts of pretreated chicken oil;
the external traditional Chinese medicine ointment is prepared by the following method:
(1) mixing decoction pieces of rhizoma Bletillae, radix Sangusorbae, Scutellariae radix, and radix Ilicis Pubescentis in proportion, adding 12 times of water, heating, reflux-extracting for 2 times (1 hr each time), filtering, mixing, concentrating to relative density of 1.20, and spray drying to obtain extract;
(2) adding a proper amount of salt into fresh chicken oil according to the formula amount by weight, pickling for 2 days, steaming for 2.5 hours in a water-proof way, completely melting the chicken oil, and taking upper-layer oil for later use;
(3) adding a proper amount of ethylparaben, vaseline and beeswax into the grease obtained in the step (2), heating to 70 ℃, melting and stirring uniformly, and cooling to room temperature; and (2) adding the extract obtained in the step (1), and the catechu and the borneol in the prescribed amount, wherein the catechu is in a powder shape, stirring uniformly, performing fine filtration, filling and sealing to obtain the tea.
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