CN104324301A - Anti-coccidiosis traditional Chinese medicine extract - Google Patents

Abstract

The invention provides an anti-coccidiosis traditional Chinese medicine extract, wherein the traditional Chinese medicine extract comprises the following components: 50-80g of antifeverile dichroa root, 50-80g of sessile stemona root, 50-80g of Chinese pulsatilla root, 40-60g of lightyellow sophora root, 40-60g of sweet wormwood herb, 40-60g of lalang grass rhizome, 40-60g of java brucea fruits, 30-50g of baical skullcap root, 30-50g of ash bark, 30-50g of pilose asiabell root, 30-50g of bletilla striata and 30-50g of bunge corydalis herb, and further comprises 100-120g of pomegranate rind, 100-120g of slenderstyle acanthopanax bark, 80-100g of Chinese usnea, 80-100g of dark plum fruits, 80-100g of swamp mahogany leaves, 80-100g of fistular onion stalks, 60-80g of pine needles, 60-80g of areca seeds, 5-10g of alum and 5-10g of fourstamen stephania root. The anti-coccidiosis traditional Chinese medicine extract provided by the invention has the advantages that the anti-coccidiosis traditional Chinese medicine extract is simple in preparation method and convenient to use, and can effectively inhibit the incidence rate of coccidiosis, increase the cure rate of the coccidiosis, prevent the coccidiosis from harming farmers during the chicken raising process and reduce the loss caused by the coccidiosis.

Description

A kind of Chinese medicine extract of anticoccidial

technical field:

The present invention relates to chicken fowl cultural technique field, particularly relate to a kind of Chinese medicine extract of anticoccidial.

 

background technology:

In the breeding process of chicken fowl, often causing chicken fowl dead because suffering from various disease, bringing about great losses to raiser, so defending and fighting against diseases is the key of cultivation.But along with drug dependence, the Drug resistance of chicken fowl is more and more stronger, causes prevention effect low, with coccidiosis, in fact causes one of principal element of chicken fowl death.The biocycle of coccidiosis is short, and 4 ~ 7 days incubation periods, reproductive capacity is very powerful, but each stage polypide of coccidiosis is only limited to intestinal mucosa and adjacent tissue thereof, and chicken once eats a small amount of egg capsule can't produce large harm.It is 20 DEG C ~ 28 DEG C that coccidiosis carries out sporiparous preference temperature, and humidity is greater than 20%, and oxygen is sufficient, and all chicken houses provide such condition just.Coccidiosis can be summarized as three aspects to the harm that chicken group causes: the morbidity in enormous quantities and the death that cause chicken; Hinder the normal growth promoter of chicken; Reduce the price of deed.It is pathogenic different that the chicken of coccidiosis to different cultivars, age, sex shows.Generally speaking, the susceptibility of young bird is comparatively large, and it is that male young susceptibility is higher than female young, and the purer susceptibility to coccidiosis of strain is higher because it obtains reliable immunity when children's age by low dose of repeated infection that large chicken falls ill less.。Coccidiosis and other cause of diseases have collaborative pathogenic effects in addition, and intestinal bacteria such as the pathogenicity to coccidiosis such as escherichia coli, Salmonella has potentiation, after coccidium infection, body also can be made to raise the susceptibility of the disease such as newcastle, fabricius bursa.

At present, coccidiosis age in days is changed in advance.Poultry in current China market with sterile products all to coccidiosis low effort.Conventional sky house disinfectant program can not kill the coccidian oocyst in hen house.Be thermokalite water and alcohol blast burner flame disinfection to the effective disinfectant measure of coccidian oocyst, such disinfectant measure can not carry out Continuous disinfection, and because corrosivity is strong and easily to implement damage, also seldom use in the sterilization of sky house.The resistance of coccidian oocyst is very strong, and generally can survive in soil 4 ~ 9 months, in the soil under tree shade, vitality reaches 15 ~ 18 months.Simultaneously in season and the area of warm moist, Development of Oocysts is very fast, and outside air temperature, 20 DEG C ~ 35 DEG C time, only needs just can form Sporulated in 18 ~ 36 hours.Therefore, in hen house, coccidian oocyst is difficult to remove clean, thus make chickling enter hen house first day rise just be in coccidium infection threat among.Clinical signs is, the chicken group lower than 7 ~ 9 ages in days will break out coccidiosis.Along with the deterioration of broiler breeding environment, the phenomenon of low Day-old Broiler Chickens morbidity is more and more common.Morbidity long-termization.The coccidiosis of past broiler multiple season being born in warm moist, but broiler is based on airtight raising at present, and brood time temperature is higher, deficiency in draught causes humidity too high, makes the pathogenetic seasonality of coccidiosis no longer obvious.Drug resistance generalizes.For many years, broiler coccidiosis mainly relies on medicine to control.Because cultivation level is low, lacks the medication guide of science, cause coccidiosis to produce general drug resistance.Investigation finds, in conventional aborning coccidiostat (QIUJING, diclazuril, clopidol, the spirit of ball dysentery, amprolium hydrochloride, robenidine hydrochloride, Maduramicin, draw arenomycin, Salinomycin etc.), worm strain over half is only to a kind of medicaments insensitive, worm strain more than 80% is to a kind or 2 kinds of medicaments insensitives, and some worm strain is all insensitive to all medicines.As can be seen here, the drug resistance of coccidiosis is very general, and the leeway of effective medicine can be selected more and more less, and this is also the unmanageable main causes of a lot of regional coccidiosis.

The symptom of broiler coccidiosis and pathological changes, clinical symptoms.Ground flat poultry morbidity is early stage discharges band bloody stool just once in a while, and quickening of searching for food at short notice, along with PD bloody stool increases, spirit is depressed, disorderly, loss of appetite, drinks for increasing feather pine, two wings are sagging, cockscomb, wattle color are pale, close one's eyes and seemingly sleep, shrink into oneself, near thermal source or squat in wall limit, mortality rate increases gradually.Cage bird, online flat poultry, normal infection small intestinal coccidiosis, in chronic process, sick chicken becomes thin, intermittent dysentery, and disorderly, eye closing shrink into oneself, feed intake declines feather pine, and feces is mixed with color filament or granulation shape thing, Radix Dauci Sativae sample thing.Pathological change.Caecum coccidiosis sees the remarkable enlargement of both sides caecum, and increase thick, outward appearance is kermesinus or atropurpureus, and interior is kermesinus blood clot or blood and slime, and is mixed with the downright bad material of intestinal mucosa, visible canescence fleck on the serosal surface of intestinal wall.The middle leading portion of small intestinal coccidiosis major determinant small intestinal, intestinal tube increases thick, and intestinal wall thickens, and cuts off and turns up, and intestinal wall is furnished with needle point size petechia, intestinal serous coat has obvious pale speckle.Chronic coccidiosis sees the slightly large chicken of age in days, and mainly small intestinal intestinal tube increases thick, and intestinal wall thickens, intestinal mucosa inflammatory swelling.

Problems existing in treating and preventing coccidiosis: too rely on medicine.Find that sulfa drugs can since anticoccidial since the forties in 20th century, develop more than 50 kind of coccidiostat, these medicines major part are applied in China, but owing to relying on medicine excessively, the problem that coccidiostat is caused aborning gets more and more.Abuse coccidiostat, accelerates the generation of coccidiosis drug resistance, shortens the drug use cycle; Anticoccidial drug residues in Carnis Gallus domesticus, reduces meat quality, threatens human health; Add the medication expense of raiser, reduce culture benefit.Disinfectant measure defect.Current domestic nothing is exclusively used in the disinfectant of coccidiosis, and flame disinfection and thermokalite water sterilization are difficult to be applied because there is too much shortcoming, so become the key of domestic effective control coccidiosis for the disinfectant measure of coccidiosis.Therapeutic regimen is chaotic.Rotation and medication of shuttling back and forth prevent and treat the ideal therapeutic regimen of coccidiosis, effectively can avoid the generation of drug resistance, but the program does not obtain popularity application in raiser.A part raiser can talk without therapeutic regimen at all, and a kind of drug use is effective, and with regard to life-time service, no longer rotation, does not shuttle back and forth.Also there are some veterinary drug producers, in order to improve the therapeutic effect of oneself product, expand market share amount, blindly multiple coccidiostat being carried out prescription, as easy as rolling off a logly make coccidiosis produce multi-drug resistant.

For the prior art of the control of coccidiosis, as Chinese patent application 20,091,009 35520 discloses Chinese medicine of a kind of coccidiosis and its production and use, composition is Rhizmoa Dryopteris Crassirhizomatis, Pericarpium Granati, Radix Dichroae, Radix Sophorae Flavescentis, Herba Cirsii.It also can mix water use by spike.As Chinese patent application 2009101578179 discloses a kind of chicken coccidia powder and preparation method thereof, component is Radix Dichroae, Herba Artemisiae Annuae, Herba Verbenae, Pulvis Talci, Radix Sophorae Flavescentis, dextrin.As Chinese patent application 2010800253541 discloses a kind of coccidiosis control agent and the feedstuff containing this coccidiosis control agent, it contains the cashew shell oil and/or Cardanol that there are heating.As Chinese patent application 2011101713623 discloses a kind of medicine preventing and treating coccidiosis, it consists of: sulfamonomethoxine 450 ~ 600 parts, NSC 408735 110 ~ 130 parts, metronidazole 145 ~ 180 parts, etamsylate 80 ~ 160 parts.For another example Chinese patent application 2013101118152 discloses a kind of medicine preventing and treating coccidiosis, component: Radix Dichroae 5-15 part, Herba Artemisiae Annuae 5-15 part, Cortex Phellodendri 5-15 part, Herba Violae 5-15 part, Cortex Lycii 4-12 part, Rhizoma Picrorhizae 4-12 part, Radix Sophorae Flavescentis 4-12 part, Radix Paeoniae Rubra 4-12 part, Semen Plantaginis 3-10 part, Radix Rehmanniae 3-10 part, Fructus Kochiae 3-10 part, Herba Dianthi 3-10 part, Radix Notoginseng 2-6 part, Radix Cyathulae 2-6 part.And for example, paper " Chinese herbal compound preparation is on the impact of Eimeria tenella infected chicken blood parameters " it discloses the Chinese medicine compounds such as Radix Phytolaccae, the Radix Pulsatillae, Radix Dichroae has good therapeutic effect to coccidiosis.And for example paper " applied research of Chinese herb prevention coccidiosis " it discloses some Chinese herbal medicine and has certain effect to coccidiosis, as Radix Dichroae, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Caryophylli, Cordyceps militaris (L.) Link., black, the Radix Pulsatillae, Fructus Bruceae, Bulbus Allii, these medicines of Herba Artemisiae Annuae can folk prescription or configuration compound recipe use, mainly because of its containing alkaloid to coccidiosis generation effect.Fructus Forsythiae, Radix Bupleuri, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Radix Et Rhizoma Rhei, Herba Patriniae, Herba Portulacae, Radix Isatidis, Herba Euphorbiae Humifusae, Herba Ecliptae have antibacterial and anti-inflammation functions, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Imperatae, Herba Cirsii, Flos Sophorae have anastalsis, said medicine all can be used as the accessory drugs of coccidiosis, but, for how composite then without statement.For another example disclosed " status and prospectives of Chinese medicine compound control chicken coccidiosis " discloses the Chinese medicine kind preventing chicken coccidiosis " Chinese veterinary pharmaceutical magazine " 4 phases in 2005, and anthelmintic class is as Radix Dichroae, Fructus Quisqualis, Fructus Bruceae, Herba Agrimoniae, the Radix Stemonae, Borneolum Syntheticum, Realgar etc.Heat clearing and damp drying class: Radix Sophorae Flavescentis, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the Radix Pulsatillae, Cortex Fraxini etc., antipyretic and antidotal type is as Herba Artemisiae Annuae, Herba Portulacae, Radix Bupleuri, Rhizoma Imperatae, Herba Taraxaci, Herba Euphorbiae Humifusae, Herba Andrographis, Herba Patriniae; Drugs for tonifying Qi and blood is as Radix Codonopsis, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Astragali, Radix Glycyrrhizae etc., and promoting blood circulation and hemostasis medicine is as Radix Salviae Miltiorrhizae, Semen Persicae, charred Radix Sanguisorbae, Herba Agrimoniae, the Pseudobulbus Bletillae (Rhizoma Bletillae) etc.According to theory of Chinese medical science, it is evil that coccidiosis belongs to diseases caused by exogenous pathogenic factor worm, and be mainly in warm moist season, the evil impairment of blood and body fluid of worm, retention of damp-heat in the interior is stranded spleen, therefore the few god of sick chicken food is idle, arranges thin excrement, has mucus just, the blood streak, thirst and liking drink, fear of cold flocks together, and cockscomb turns white, and body is become thin, and exhaustion is dead.Therefore treatment should kill worm heresy, reducing phlegm and internal heat dries is main, tonification vim and vigour, and cooling blood for hemostasis is auxiliary.

Based on above-mentioned prior art, purport of the present invention provides a kind of method simple on the basis of existing technology, easy to use, can effectively suppress coccidiosis sickness rate, increase coccidiosis cure rate, in poultry process, avoid coccidiosis to endanger raiser, reduce the Chinese medicine extract of a kind of anticoccidial of the therefore sick loss caused.

 

summary of the invention:

The object of the invention is to overcome the shortcoming existed in prior art, there is provided a kind of method simple, easy to use, can effectively suppress coccidiosis sickness rate, increase coccidiosis cure rate, in poultry process, avoid coccidiosis to endanger raiser, reduce the Chinese medicine extract of a kind of anticoccidial of the therefore sick loss caused.

In order to solve this technical problem, the invention discloses a kind of Chinese medicine extract of anticoccidial, it is characterized in that, operate in accordance with the following steps:

A, spice: Chinese medicine extract mixes feedstuff, Chinese medicine extract with quality of the fodder ratio is, summer 2:100, spring and autumn 1:100, winter 0.5:100; Use one week and stop using one week, so repeatedly;

B, drinking-water: Chinese medicine extract is mixed in water and quotes for chicken fowl, is allocated as mass percent 8% summer, is allocated as mass percent 5% spring and autumn, be allocated as mass percent 2% winter; Use one week and stop using one week, so repeatedly;

C, sprinkling cage house: Chinese medicine extract is mixed in water, sprays cage house and chicken body, is allocated as mass percent 35% summer, is allocated as mass percent 20% spring and autumn, be allocated as mass percent 15% winter; Use one week and stop using one week, so repeatedly;

Steps A, B, C interval intersect or operate simultaneously;

So-called interval, for operating B after operation A, operates C after operation B, then continues from A, so repeatedly.

The while that so-called intersection being for operation A and B; Then operate C, or B and C simultaneously; Then operate A, or A and C simultaneously, then operates B;

Simultaneously so-called, refer to that ABC operates simultaneously, after stopping one week, continue ABC and operate simultaneously.

The component of described Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 50-80g of the Radix Pulsatillae, the each 40-60g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 30-50g of Herba Violae, comprise further: each 100-120g of Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, each 80-100g of Bulbus Allii Fistulosi, Folium Pini, each 60-80g of Semen Arecae, Alumen, Radix Stephaniae Tetrandrae 5-10g.

Time prepared by Chinese medicine extract, Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;

By Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, Bulbus Allii Fistulosi, Folium Pini, Semen Arecae, Alumen, Radix Stephaniae Tetrandrae, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 0.2-0.4% of powder quality, obtains powder after mix homogeneously;

Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.

Advantage of the present invention is: method is simple, easy to use, can effectively suppress coccidiosis sickness rate, increases coccidiosis cure rate, avoids coccidiosis to endanger raiser in poultry process, reduces the therefore sick loss caused, is specially:

The present invention (Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae) on the basis of the common drug of control coccidiosis, further interpolation (Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, Bulbus Allii Fistulosi, Folium Pini, Semen Arecae, Alumen, Radix Stephaniae Tetrandrae), to strengthen the prevention effect of coccidiosis of going out.

Radix Dichroae, the Radix Stemonae, Fructus Bruceae, Radix Sophorae Flavescentis drive insect medicine for conventional in conventional coccidiosis medicine, the Radix Pulsatillae, Radix Scutellariae, Cortex Fraxini are dampness medicine conventional in conventional coccidiosis medicine, Herba Artemisiae Annuae, Rhizoma Imperatae, Herba Violae are heat and toxic materials clearing away medicine conventional in conventional coccidiosis medicine, Radix Codonopsis is drugs for tonifying Qi and blood conventional in conventional coccidiosis medicine, the Pseudobulbus Bletillae (Rhizoma Bletillae) is promoting blood circulation and hemostasis medicine conventional in conventional coccidiosis medicine

Tannin anthelmintic in Pericarpium Granati, anti-bacteria and anti-virus, Cortex Acanthopancis total saponins and polysaccharide are then improved the effect of body's immunity, resisting pathogenic microbes effect: experiment in vitro shows: Radix Et Caulis Acanthopanacis Senticosi water decoction has inhibitory action to Staphylococcus albus. also there is certain antibacterial effect to Neisseria, escherichia coli. and Radix Et Caulis Acanthopanacis Senticosi polysaccharide has tubercle bacillus affection certain resists effect.Radix Stephaniae Tetrandrae contains Aristolochic Acid, reduces its dosage, and Radix Stephaniae Tetrandrae A prime, B prime all have pest-resistant effect.Usnic acid has antibacterial action, has inhibitory action to insects, especially protozoon.The acids especially hydrocyanic acid of Fructus Mume, has resisting pathogenic microbes effect, has inhibitory action to insects.The volatile oil eliminating inflammation and expelling toxin analgesia of Folium Eucalypti Robustae is antibacterial presses down worm, and the phlegmatic temperament of Bulbus Allii Fistulosi is containing volatile oil (allicin, two allyl thioethers), and suppress pathogenic microorganism, phlegmatic temperament has protective effect to mucosa, has anthelmintic action.Folium Pini contains and enriches aminoacid, blood circulation promoting, improves the function of blood capillary, improves immunity, increases hormonal secretion.Alumen, Semen Arecae volatile oil have anthelmintic action.The interior hemostasis of Alumen, Radix Stephaniae Tetrandrae, antibacterial, external parasite killing.

detailed description of the invention:

The Chinese medicine extract of anticoccidial of the present invention, wherein, operates in accordance with the following steps:

A, spice: Chinese medicine extract mixes feedstuff, Chinese medicine extract with quality of the fodder ratio is, summer 2:100, spring and autumn 1:100, winter 0.5:100; Use one week and stop using one week, so repeatedly;

B, drinking-water: Chinese medicine extract is mixed in water and quotes for chicken fowl, is allocated as mass percent 8% summer, is allocated as mass percent 5% spring and autumn, be allocated as mass percent 2% winter; Use one week and stop using one week, so repeatedly;

C, sprinkling cage house: Chinese medicine extract is mixed in water, sprays cage house and chicken body, is allocated as mass percent 35% summer, is allocated as mass percent 20% spring and autumn, be allocated as mass percent 15% winter; Use one week and stop using one week, so repeatedly;

Steps A, B, C interval intersect or operate simultaneously;

So-called interval, for operating B after operation A, operates C after operation B, then continues from A, so repeatedly.

The while that so-called intersection being for operation A and B; Then operate C, or B and C simultaneously; Then operate A, or A and C simultaneously, then operates B;

Simultaneously so-called, refer to that ABC operates simultaneously, after stopping one week, continue ABC and operate simultaneously.

The component of described Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 50-80g of the Radix Pulsatillae, the each 40-60g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 30-50g of Herba Violae, comprise further: each 100-120g of Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, each 80-100g of Bulbus Allii Fistulosi, Folium Pini, each 60-80g of Semen Arecae, Alumen, Radix Stephaniae Tetrandrae 5-10g.

Time prepared by Chinese medicine extract, Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;

By Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, Bulbus Allii Fistulosi, Folium Pini, Semen Arecae, Alumen, Radix Stephaniae Tetrandrae, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 02-0.4% of powder quality, obtains powder after mix homogeneously;

Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.

 

Object lesson 1:

Zhou Jia plant 7000 chickens cultivate in a cage house, start to delivering for sale from chicken.Make with the following method:

A, spice: Chinese medicine extract mixes feedstuff, Chinese medicine extract with quality of the fodder ratio is, summer 2:100, spring and autumn 1:100, winter 0.5:100; Use one week and stop using one week, so repeatedly;

B, drinking-water: Chinese medicine extract is mixed in water and quotes for chicken fowl, is allocated as mass percent 8% summer, is allocated as mass percent 5% spring and autumn, be allocated as mass percent 2% winter; Use one week and stop using one week, so repeatedly;

C, sprinkling cage house: Chinese medicine extract is mixed in water, sprays cage house and chicken body, is allocated as mass percent 35% summer, is allocated as mass percent 20% spring and autumn, be allocated as mass percent 15% winter; Use one week and stop using one week, so repeatedly;

Steps A, B, C intermittently operated;

So-called interval, for operating B after operation A, operates C after operation B, then continues from A, so repeatedly.

The component of Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 80g of the Radix Pulsatillae, the each 60g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 50g of Herba Violae, comprise further: each 120g of Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, each 100g of Bulbus Allii Fistulosi, Folium Pini, each 80g of Semen Arecae, Alumen, Radix Stephaniae Tetrandrae 10g.

Time prepared by Chinese medicine extract, Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;

By Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, Bulbus Allii Fistulosi, Folium Pini, Semen Arecae, Alumen, Radix Stephaniae Tetrandrae, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 0.2-0.4% of powder quality, obtains powder after mix homogeneously;

Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.

Young chicken period coccidium infection rate 2.3%, in large chicken stage coccidium infection rate 2.1%, become chicken stage coccidium infection rate 1.8%.

 

Object lesson 2:

Great Xin town Ma Jia plant 6000 chickens, start to delivering for sale from chicken.Make with the following method:

A, spice: Chinese medicine extract mixes feedstuff, Chinese medicine extract with quality of the fodder ratio is, summer 2:100, spring and autumn 1:100, winter 0.5:100; Use one week and stop using one week, so repeatedly;

B, drinking-water: Chinese medicine extract is mixed in water and quotes for chicken fowl, is allocated as mass percent 8% summer, is allocated as mass percent 5% spring and autumn, be allocated as mass percent 2% winter; Use one week and stop using one week, so repeatedly;

C, sprinkling cage house: Chinese medicine extract is mixed in water, sprays cage house and chicken body, is allocated as mass percent 35% summer, is allocated as mass percent 20% spring and autumn, be allocated as mass percent 15% winter; Use one week and stop using one week, so repeatedly;

Steps A, B, C interlace operation;

The while that so-called intersection being for operation A and B; Then operate C, or B and C simultaneously; Then operate A, or A and C simultaneously, then operates B; (invention be preferably steps A+B carry out simultaneously, A+B stop using one week time, operating procedure C)

The component of described Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 70g of the Radix Pulsatillae, the each 50g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 40g of Herba Violae, comprise further: each 110g of Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, each 90g of Bulbus Allii Fistulosi, Folium Pini, each 70g of Semen Arecae, Alumen, Radix Stephaniae Tetrandrae 8g.

Time prepared by Chinese medicine extract, Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;

By Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, Bulbus Allii Fistulosi, Folium Pini, Semen Arecae, Alumen, Radix Stephaniae Tetrandrae, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 02-0.4% of powder quality, obtains powder after mix homogeneously;

Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.

Young chicken period coccidium infection rate 2.1%, in large chicken stage coccidium infection rate 2.0%, become chicken stage coccidium infection rate 1.7%.

 

Example 3

Plant of Mao San village, Duan Bolan town 6000 chickens, make with the following method from chicken to delivering for sale:

A, spice: Chinese medicine extract mixes feedstuff, Chinese medicine extract with quality of the fodder ratio is, summer 2:100, spring and autumn 1:100, winter 0.5:100; Use one week and stop using one week, so repeatedly;

B, drinking-water: Chinese medicine extract is mixed in water and quotes for chicken fowl, is allocated as mass percent 8% summer, is allocated as mass percent 5% spring and autumn, be allocated as mass percent 2% winter; Use one week and stop using one week, so repeatedly;

C, sprinkling cage house: Chinese medicine extract is mixed in water, sprays cage house and chicken body, is allocated as mass percent 35% summer, is allocated as mass percent 20% spring and autumn, be allocated as mass percent 15% winter; Use one week and stop using one week, so repeatedly;

Steps A, B, C operate simultaneously;

Simultaneously so-called, refer to that ABC operates simultaneously, after stopping one week, continue ABC and operate simultaneously.

The component of described Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 50-80g of the Radix Pulsatillae, the each 40-60g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 30-50g of Herba Violae, comprise further: each 100-120g of Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, each 80-100g of Bulbus Allii Fistulosi, Folium Pini, each 60-80g of Semen Arecae, Alumen, Radix Stephaniae Tetrandrae 5-10g.

Time prepared by Chinese medicine extract, Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;

By Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, Bulbus Allii Fistulosi, Folium Pini, Semen Arecae, Alumen, Radix Stephaniae Tetrandrae, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 02-0.4% of powder quality, obtains powder after mix homogeneously;

Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.

Young chicken period coccidium infection rate 2.0%, in large chicken stage coccidium infection rate 1.8%, become chicken stage coccidium infection rate 1.4%.

 

The experiment that Chinese medicine extract improves immunity is compared:

Example 1, example 2, example 3 respectively select each 30 of the chicken of identical age in days (60 age in days), as experimental group one, experimental group two, experimental group three.

Select the chicken of 60 ages in days of 30 common daily rations of feeding as a control group.The body weight gap of the chicken of three experimental grouies and matched group is less than 10g.

Relatively 1 is as follows: matched group and three each Stochastic choice of experimental group 10, be placed in dark environment and exposure environment, discovery for three days on end respectively repeatedly:

Relatively 2 is as follows: remaining experimental group and matched group each 20 are merely hit, more often organize Stochastic choice 10, carries out labelling, be then placed in same environment, then drop into the sick chicken 5 suffering from coccidiosis, carries out infecting experiment, observe after 3 days.

Relatively 3 is as follows: after above-mentioned twice contrast, matched group and three experimental grouies respectively remain 10, carry out labelling, are then placed in same environment, drop into the sick chicken 5 suffering from coccidiosis again, carry out infecting experiment, after 5 days, experimental group one has 3 to catch an illness, and experimental group two has 2 to catch an illness, experimental group three has 2 to catch an illness, matched group has 7 to catch an illness, and is dissected by the sick chicken of three experimental grouies and matched group, observes, detects intestinal.

By above-mentioned contrast, can find, the incidence of three experimental grouies is obviously lighter than matched group, and matched group incidence is serious.

 

Get chicken fowl 440 plumage of 40 ages in days, weight differences is less than 10g, and be divided into 11 groups at random, often group carries out labelling, then only carries out nature with the sick chicken 100 of coccidiosis and raises together with and infect (time-division in summer)

Feed by the embodiment of the present invention 1 for 1 group, last 14 days,

Feed by the embodiment of the present invention 2 for 2 groups, last 14 days,

Feed by the embodiment of the present invention 3 for 3 groups, last 14 days,

Feed according to steps A feeding patterns in summer drinking-water of the present invention, last 14 days for 4 groups,

Feed according to step B feeding patterns in summer spice of the present invention, last 14 days for 5 groups,

6 groups are sprayed according to step C feeding patterns in summer cage house of the present invention, last 14 days,

7 groups use medicated powder of the present invention (Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae to be mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, and after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder; ), water mixing is drunk, and lasts 14 days, mass percent 8%;

8 groups use medicated powder of the present invention, and medicated powder and feeding quality are than 2:100, and feeding, lasts 14 days,

9 groups use medicated powder of the present invention, the modulation quality that adds water percentage ratio 45%, spray cage house, last 14 days,

10 groups use background technologies 2013101118152 technical scheme, feeding, lasts 14 days,

11 groups use common daily forage feed, last 14 days, as a control group

Above-mentioned each group in morning on the 15th on an empty stomach, record experimental session mortality rate, all chicken fowl killed again all carries out intestinal lesion score, collects feces and carries out coccidiosis counting, weight when slaughtering.

Data target:

Mortality rate=(often group infects chicken sum in the lethal chicken number/group of coccidiosis) × 100%

Rate of body weight gain=(average weight gain of the average weight gain/matched group of each infected group) × 100%

The order of severity cuing open the intestinal of inspection after lesion score=pathological changes is scored respectively

Pathological changes value=often organizes average × 10 of experimental group lesion score

Egg capsule counting=often organize in the feces of the 7th day infecting sick chicken, multiple spot chooses fresh excreta 5g, add 10ml normal saline, stir, put into test tube with a scale and deposit 30 minutes, then add saturated aqueous common salt, do 10 times of dilutions, counting (counting is observed in Stochastic choice 5 visuals field, then averages) after mixing

Egg capsule ratio=(experimental group egg sac number/matched group egg sac number) × 100%

Egg capsule value: egg capsule is than numerical digit 0-1%, and egg capsule value is 0.

Be 5 during 2-25%

26-50% is 10

Be 20 during 51-75%

Be 40 during 76-100%

Anticoccidial Index A CI:(percentage weight increase+survival rate)-(pathological changes value+egg capsule value)

It is 120 invalid that ACI is less than or equal to,

ACI is effectively medium at 120-160

ACI is good at 160-180

ACI is outstanding when being greater than 180.

 

The results list is as follows:

Group	Average weight gain	The relative weight gain	Survival rate	Enteropathy variate	Egg capsule value	ACI
							1	212	95.1	100	8.8	5	181.3
2	220	95.6	100	8.5	5	182.1
							3	205	95.0	100	8.4	5	181.6
4	192	89.3	100	10.2	10	169.1
							5	198	90.5	100	11.0	10	169.5
6	175	83.6	98	12.9	10	158.7
							7	152	77.3	86	17.6	20	125.7
8	159	78.6	87	16.9	20	128.7
							9	134	59.8	67	26.7	20	80.1
10	167	78.4	82	18.6	10	131.8
							Contrast	237	100	100	0	0	200

By above-mentioned comparison, can find, the ACI of embodiment 1-3 is greater than 180, excellent,

Independent employing steps A, adopts separately step B, ACI to be positioned at 160-180, respond well

Independent employing step C, ACI are close to 160, effectively medium

As the medicated powder part of prior art, drinking-water and spice ACI are positioned at 120-160 interval, effectively medium.Spraying operation is less than 120, invalid.

As 2013101118152 technical schemes of prior art, ACI is positioned at 120-160 interval, effectively medium.

 

Select Chinese medicine extract of the present invention, do the experiment of toxicity to rat:

Acute oral (LD50) > 500mg/kg,

Acute percutaneous (LD50) > 2000mg/kg,

Belong to low toxicity.

 

The corresponding feed used in the present invention, in embodiment, in experimental group, matched group is as follows: (for unified experimental standard)

The field corn 55.3% of chickling, bean cake 38%, calcium hydrogen phosphate 1.4%, stone powder 1%, Sal 0.3%, oil 3%, additive 1%.The field corn 58.2% of middle chicken, bean cake 35%, calcium hydrogen phosphate 1.4%, stone powder 1.1%, Sal 0.3%, oil 3%, additive 1%.The field corn 59.2% of large chicken, Testa Tritici 2%, bean cake 22.5%, rapeseed cake 9.5%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, oil 3%, additive 1%.

 

Advantage of the present invention is: method is simple, easy to use, can effectively suppress coccidiosis sickness rate, increases coccidiosis cure rate, avoids coccidiosis to endanger raiser in poultry process, reduces the therefore sick loss caused, is specially:

The present invention (Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae) on the basis of the common drug of control coccidiosis, further interpolation (Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, Bulbus Allii Fistulosi, Folium Pini, Semen Arecae, Alumen, Radix Stephaniae Tetrandrae), to strengthen the prevention effect of coccidiosis of going out.

Radix Dichroae, the Radix Stemonae, Fructus Bruceae, Radix Sophorae Flavescentis drive insect medicine for conventional in conventional coccidiosis medicine, the Radix Pulsatillae, Radix Scutellariae, Cortex Fraxini are dampness medicine conventional in conventional coccidiosis medicine, Herba Artemisiae Annuae, Rhizoma Imperatae, Herba Violae are heat and toxic materials clearing away medicine conventional in conventional coccidiosis medicine, Radix Codonopsis is drugs for tonifying Qi and blood conventional in conventional coccidiosis medicine, the Pseudobulbus Bletillae (Rhizoma Bletillae) is promoting blood circulation and hemostasis medicine conventional in conventional coccidiosis medicine

Tannin anthelmintic in Pericarpium Granati, anti-bacteria and anti-virus, Cortex Acanthopancis total saponins and polysaccharide are then improved the effect of body's immunity, resisting pathogenic microbes effect: experiment in vitro shows: Radix Et Caulis Acanthopanacis Senticosi water decoction has inhibitory action to Staphylococcus albus. also there is certain antibacterial effect to Neisseria, escherichia coli. and Radix Et Caulis Acanthopanacis Senticosi polysaccharide has tubercle bacillus affection certain resists effect.Radix Stephaniae Tetrandrae contains Aristolochic Acid, reduces its dosage, and Radix Stephaniae Tetrandrae A prime, B prime all have pest-resistant effect.Usnic acid has antibacterial action, has inhibitory action to insects, especially protozoon.The acids especially hydrocyanic acid of Fructus Mume, has resisting pathogenic microbes effect, has inhibitory action to insects.The volatile oil eliminating inflammation and expelling toxin analgesia of Folium Eucalypti Robustae is antibacterial presses down worm, and the phlegmatic temperament of Bulbus Allii Fistulosi is containing volatile oil (allicin, two allyl thioethers), and suppress pathogenic microorganism, phlegmatic temperament has protective effect to mucosa, has anthelmintic action.Folium Pini contains and enriches aminoacid, blood circulation promoting, improves the function of blood capillary, improves immunity, increases hormonal secretion.Alumen, Semen Arecae volatile oil have anthelmintic action.The interior hemostasis of Alumen, Radix Stephaniae Tetrandrae, antibacterial, external parasite killing.

Claims (1)

1. a Chinese medicine extract for anticoccidial, is characterized in that,

The component of described Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 50-80g of the Radix Pulsatillae, the each 40-60g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 30-50g of Herba Violae, comprise further: each 100-120g of Pericarpium Granati, Cortex Acanthopancis, Usnea, Fructus Mume, Folium Eucalypti Robustae, each 80-100g of Bulbus Allii Fistulosi, Folium Pini, each 60-80g of Semen Arecae, Alumen, Radix Stephaniae Tetrandrae 5-10g.