CN104324300A - Preparation method of traditional Chinese medicine extract for farming chicken poultry - Google Patents

Preparation method of traditional Chinese medicine extract for farming chicken poultry Download PDF

Info

Publication number
CN104324300A
CN104324300A CN201410574361.7A CN201410574361A CN104324300A CN 104324300 A CN104324300 A CN 104324300A CN 201410574361 A CN201410574361 A CN 201410574361A CN 104324300 A CN104324300 A CN 104324300A
Authority
CN
China
Prior art keywords
radix
coccidiosis
powder
chinese medicine
root
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410574361.7A
Other languages
Chinese (zh)
Inventor
曲田桂
赵永涛
吴德专
王海丽
马丕云
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qingdao Tianrui Poultry Equipment Co Ltd
Original Assignee
Qingdao Tianrui Poultry Equipment Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qingdao Tianrui Poultry Equipment Co Ltd filed Critical Qingdao Tianrui Poultry Equipment Co Ltd
Priority to CN201410574361.7A priority Critical patent/CN104324300A/en
Publication of CN104324300A publication Critical patent/CN104324300A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/86—Violaceae (Violet family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Abstract

The invention provides a preparation method of a traditional Chinese medicine extract for farming chicken poultry, wherein the preparation method is operated according to the following steps: mixing antifeverile dichroa root, sessile stemona root, Chinese pulsatilla root, lightyellow sophora root, sweet wormwood herb, lalang grass rhizome, java brucea fruits, baical skullcap root, ash bark, pilose asiabell root, bletilla striata and bunge corydalis herb together, so as to obtain medicine powder by a petroleum ether reflux method; mixing densefruit pittany root-bark, levant cotton root, mexican tea herb, swordlike atractylodes rhizome, largetrifoliolious bugbane rhizome, purpleflower holly leaves, clematis root, pine needles, alum and pricklyash peel together, and extracting by a water extraction method to obtain a powder agent; and mixing the medicine powder and the powder agent according to the mass ratio of 3: 1, and uniformly mixing to obtain the traditional Chinese medicine extract. The preparation method provided by the invention has the advantages that the method is simple and convenient to use, and the traditional Chinese medicine extract can effectively inhibit the incidence rate of coccidiosis, increase the cure rate of the coccidiosis, prevent the coccidiosis from harming farmers during the chicken raising process and reduce the loss caused by the coccidiosis.

Description

A kind of preparation method of chicken fowl cultivation Chinese medicine extract
technical field:
The present invention relates to chicken fowl cultural technique field, particularly relate to a kind of preparation method of chicken fowl cultivation Chinese medicine extract.
 
background technology:
In the breeding process of chicken fowl, often causing chicken fowl dead because suffering from various disease, bringing about great losses to raiser, so defending and fighting against diseases is the key of cultivation.But along with drug dependence, the Drug resistance of chicken fowl is more and more stronger, causes prevention effect low, with coccidiosis, in fact causes one of principal element of chicken fowl death.The biocycle of coccidiosis is short, and 4 ~ 7 days incubation periods, reproductive capacity is very powerful, but each stage polypide of coccidiosis is only limited to intestinal mucosa and adjacent tissue thereof, and chicken once eats a small amount of egg capsule can't produce large harm.It is 20 DEG C ~ 28 DEG C that coccidiosis carries out sporiparous preference temperature, and humidity is greater than 20%, and oxygen is sufficient, and all chicken houses provide such condition just.Coccidiosis can be summarized as three aspects to the harm that chicken group causes: the morbidity in enormous quantities and the death that cause chicken; Hinder the normal growth promoter of chicken; Reduce the price of deed.It is pathogenic different that the chicken of coccidiosis to different cultivars, age, sex shows.Generally speaking, the susceptibility of young bird is comparatively large, and it is that male young susceptibility is higher than female young, and the purer susceptibility to coccidiosis of strain is higher because it obtains reliable immunity when children's age by low dose of repeated infection that large chicken falls ill less.。Coccidiosis and other cause of diseases have collaborative pathogenic effects in addition, and intestinal bacteria such as the pathogenicity to coccidiosis such as escherichia coli, Salmonella has potentiation, after coccidium infection, body also can be made to raise the susceptibility of the disease such as newcastle, fabricius bursa.
At present, coccidiosis age in days is changed in advance.Poultry in current China market with sterile products all to coccidiosis low effort.Conventional sky house disinfectant program can not kill the coccidian oocyst in hen house.Be thermokalite water and alcohol blast burner flame disinfection to the effective disinfectant measure of coccidian oocyst, such disinfectant measure can not carry out Continuous disinfection, and because corrosivity is strong and easily to implement damage, also seldom use in the sterilization of sky house.The resistance of coccidian oocyst is very strong, and generally can survive in soil 4 ~ 9 months, in the soil under tree shade, vitality reaches 15 ~ 18 months.Simultaneously in season and the area of warm moist, Development of Oocysts is very fast, and outside air temperature, 20 DEG C ~ 35 DEG C time, only needs just can form Sporulated in 18 ~ 36 hours.Therefore, in hen house, coccidian oocyst is difficult to remove clean, thus make chickling enter hen house first day rise just be in coccidium infection threat among.Clinical signs is, the chicken group lower than 7 ~ 9 ages in days will break out coccidiosis.Along with the deterioration of broiler breeding environment, the phenomenon of low Day-old Broiler Chickens morbidity is more and more common.Morbidity long-termization.The coccidiosis of past broiler multiple season being born in warm moist, but broiler is based on airtight raising at present, and brood time temperature is higher, deficiency in draught causes humidity too high, makes the pathogenetic seasonality of coccidiosis no longer obvious.Drug resistance generalizes.For many years, broiler coccidiosis mainly relies on medicine to control.Because cultivation level is low, lacks the medication guide of science, cause coccidiosis to produce general drug resistance.Investigation finds, in conventional aborning coccidiostat (QIUJING, diclazuril, clopidol, the spirit of ball dysentery, amprolium hydrochloride, robenidine hydrochloride, Maduramicin, draw arenomycin, Salinomycin etc.), worm strain over half is only to a kind of medicaments insensitive, worm strain more than 80% is to a kind or 2 kinds of medicaments insensitives, and some worm strain is all insensitive to all medicines.As can be seen here, the drug resistance of coccidiosis is very general, and the leeway of effective medicine can be selected more and more less, and this is also the unmanageable main causes of a lot of regional coccidiosis.
The symptom of broiler coccidiosis and pathological changes, clinical symptoms.Ground flat poultry morbidity is early stage discharges band bloody stool just once in a while, and quickening of searching for food at short notice, along with PD bloody stool increases, spirit is depressed, disorderly, loss of appetite, drinks for increasing feather pine, two wings are sagging, cockscomb, wattle color are pale, close one's eyes and seemingly sleep, shrink into oneself, near thermal source or squat in wall limit, mortality rate increases gradually.Cage bird, online flat poultry, normal infection small intestinal coccidiosis, in chronic process, sick chicken becomes thin, intermittent dysentery, and disorderly, eye closing shrink into oneself, feed intake declines feather pine, and feces is mixed with color filament or granulation shape thing, Radix Dauci Sativae sample thing.Pathological change.Caecum coccidiosis sees the remarkable enlargement of both sides caecum, and increase thick, outward appearance is kermesinus or atropurpureus, and interior is kermesinus blood clot or blood and slime, and is mixed with the downright bad material of intestinal mucosa, visible canescence fleck on the serosal surface of intestinal wall.The middle leading portion of small intestinal coccidiosis major determinant small intestinal, intestinal tube increases thick, and intestinal wall thickens, and cuts off and turns up, and intestinal wall is furnished with needle point size petechia, intestinal serous coat has obvious pale speckle.Chronic coccidiosis sees the slightly large chicken of age in days, and mainly small intestinal intestinal tube increases thick, and intestinal wall thickens, intestinal mucosa inflammatory swelling.
Problems existing in treating and preventing coccidiosis: too rely on medicine.Find that sulfa drugs can since anticoccidial since the forties in 20th century, develop more than 50 kind of coccidiostat, these medicines major part are applied in China, but owing to relying on medicine excessively, the problem that coccidiostat is caused aborning gets more and more.Abuse coccidiostat, accelerates the generation of coccidiosis drug resistance, shortens the drug use cycle; Anticoccidial drug residues in Carnis Gallus domesticus, reduces meat quality, threatens human health; Add the medication expense of raiser, reduce culture benefit.Disinfectant measure defect.Current domestic nothing is exclusively used in the disinfectant of coccidiosis, and flame disinfection and thermokalite water sterilization are difficult to be applied because there is too much shortcoming, so become the key of domestic effective control coccidiosis for the disinfectant measure of coccidiosis.Therapeutic regimen is chaotic.Rotation and medication of shuttling back and forth prevent and treat the ideal therapeutic regimen of coccidiosis, effectively can avoid the generation of drug resistance, but the program does not obtain popularity application in raiser.A part raiser can talk without therapeutic regimen at all, and a kind of drug use is effective, and with regard to life-time service, no longer rotation, does not shuttle back and forth.Also there are some veterinary drug producers, in order to improve the therapeutic effect of oneself product, expand market share amount, blindly multiple coccidiostat being carried out prescription, as easy as rolling off a logly make coccidiosis produce multi-drug resistant.
For the prior art of the control of coccidiosis, as Chinese patent application 20,091,009 35520 discloses Chinese medicine of a kind of coccidiosis and its production and use, composition is Rhizmoa Dryopteris Crassirhizomatis, Pericarpium Granati, Radix Dichroae, Radix Sophorae Flavescentis, Herba Cirsii.It also can mix water use by spike.As Chinese patent application 2009101578179 discloses a kind of chicken coccidia powder and preparation method thereof, component is Radix Dichroae, Herba Artemisiae Annuae, Herba Verbenae, Pulvis Talci, Radix Sophorae Flavescentis, dextrin.As Chinese patent application 2010800253541 discloses a kind of coccidiosis control agent and the feedstuff containing this coccidiosis control agent, it contains the cashew shell oil and/or Cardanol that there are heating.As Chinese patent application 2011101713623 discloses a kind of medicine preventing and treating coccidiosis, it consists of: sulfamonomethoxine 450 ~ 600 parts, NSC 408735 110 ~ 130 parts, metronidazole 145 ~ 180 parts, etamsylate 80 ~ 160 parts.For another example Chinese patent application 2013101118152 discloses a kind of medicine preventing and treating coccidiosis, component: Radix Dichroae 5-15 part, Herba Artemisiae Annuae 5-15 part, Cortex Phellodendri 5-15 part, Herba Violae 5-15 part, Cortex Lycii 4-12 part, Rhizoma Picrorhizae 4-12 part, Radix Sophorae Flavescentis 4-12 part, Radix Paeoniae Rubra 4-12 part, Semen Plantaginis 3-10 part, Radix Rehmanniae 3-10 part, Fructus Kochiae 3-10 part, Herba Dianthi 3-10 part, Radix Notoginseng 2-6 part, Radix Cyathulae 2-6 part.And for example, paper " Chinese herbal compound preparation is on the impact of Eimeria tenella infected chicken blood parameters " it discloses the Chinese medicine compounds such as Radix Phytolaccae, the Radix Pulsatillae, Radix Dichroae has good therapeutic effect to coccidiosis.And for example paper " applied research of Chinese herb prevention coccidiosis " it discloses some Chinese herbal medicine and has certain effect to coccidiosis, as Radix Dichroae, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Caryophylli, Cordyceps militaris (L.) Link., black, the Radix Pulsatillae, Fructus Bruceae, Bulbus Allii, these medicines of Herba Artemisiae Annuae can folk prescription or configuration compound recipe use, mainly because of its containing alkaloid to coccidiosis generation effect.Fructus Forsythiae, Radix Bupleuri, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Radix Et Rhizoma Rhei, Herba Patriniae, Herba Portulacae, Radix Isatidis, Herba Euphorbiae Humifusae, Herba Ecliptae have antibacterial and anti-inflammation functions, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Imperatae, Herba Cirsii, Flos Sophorae have anastalsis, said medicine all can be used as the accessory drugs of coccidiosis, but, for how composite then without statement.For another example disclosed " status and prospectives of Chinese medicine compound control chicken coccidiosis " discloses the Chinese medicine kind preventing chicken coccidiosis " Chinese veterinary pharmaceutical magazine " 4 phases in 2005, and anthelmintic class is as Radix Dichroae, Fructus Quisqualis, Fructus Bruceae, Herba Agrimoniae, the Radix Stemonae, Borneolum Syntheticum, Realgar etc.Heat clearing and damp drying class: Radix Sophorae Flavescentis, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, the Radix Pulsatillae, Cortex Fraxini etc., antipyretic and antidotal type is as Herba Artemisiae Annuae, Herba Portulacae, Radix Bupleuri, Rhizoma Imperatae, Herba Taraxaci, Herba Euphorbiae Humifusae, Herba Andrographis, Herba Patriniae; Drugs for tonifying Qi and blood is as Radix Codonopsis, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Astragali, Radix Glycyrrhizae etc., and promoting blood circulation and hemostasis medicine is as Radix Salviae Miltiorrhizae, Semen Persicae, charred Radix Sanguisorbae, Herba Agrimoniae, the Pseudobulbus Bletillae (Rhizoma Bletillae) etc.According to theory of Chinese medical science, it is evil that coccidiosis belongs to diseases caused by exogenous pathogenic factor worm, and be mainly in warm moist season, the evil impairment of blood and body fluid of worm, retention of damp-heat in the interior is stranded spleen, therefore the few god of sick chicken food is idle, arranges thin excrement, has mucus just, the blood streak, thirst and liking drink, fear of cold flocks together, and cockscomb turns white, and body is become thin, and exhaustion is dead.Therefore treatment should kill worm heresy, reducing phlegm and internal heat dries is main, tonification vim and vigour, and cooling blood for hemostasis is auxiliary.
Based on above-mentioned prior art, purport of the present invention provides a kind of method simple on the basis of existing technology, easy to use, can effectively suppress coccidiosis sickness rate, increase coccidiosis cure rate, in poultry process, avoid coccidiosis to endanger raiser, reduce the preparation method of a kind of chicken fowl cultivation Chinese medicine extract of the therefore sick loss caused.
 
summary of the invention:
The object of the invention is to overcome the shortcoming existed in prior art, there is provided a kind of method simple, easy to use, can effectively suppress coccidiosis sickness rate, increase coccidiosis cure rate, in poultry process, avoid coccidiosis to endanger raiser, reduce the preparation method of a kind of chicken fowl cultivation Chinese medicine extract of the therefore sick loss caused.
In order to solve this technical problem, the invention discloses a kind of preparation method of chicken fowl cultivation Chinese medicine extract, it is characterized in that, operate in accordance with the following steps:
A, spice: Chinese medicine extract mixes feedstuff, Chinese medicine extract with quality of the fodder ratio is, summer 2:100, spring and autumn 1:100, winter 0.5:100; Use one week and stop using one week, so repeatedly;
B, drinking-water: Chinese medicine extract is mixed in water and quotes for chicken fowl, is allocated as mass percent 8% summer, is allocated as mass percent 5% spring and autumn, be allocated as mass percent 2% winter; Use one week and stop using one week, so repeatedly;
C, sprinkling cage house: Chinese medicine extract is mixed in water, sprays cage house and chicken body, is allocated as mass percent 35% summer, is allocated as mass percent 20% spring and autumn, be allocated as mass percent 15% winter; Use one week and stop using one week, so repeatedly;
Steps A, B, C interval intersect or operate simultaneously;
So-called interval, for operating B after operation A, operates C after operation B, then continues from A, so repeatedly.
The while that so-called intersection being for operation A and B; Then operate C, or B and C simultaneously; Then operate A, or A and C simultaneously, then operates B;
Simultaneously so-called, refer to that ABC operates simultaneously, after stopping one week, continue ABC and operate simultaneously.
The component of described Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 50-80g of the Radix Pulsatillae, the each 40-60g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 30-50g of Herba Violae, comprise further: each 100-120g of Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, each 80-100g of Radix Clematidis, Folium Pini, each 60-80g of Pericarpium Zanthoxyli, Alumen 5-10g.
Time prepared by Chinese medicine extract, Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;
By Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Clematidis, Folium Pini, Alumen, Pericarpium Zanthoxyli, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 0.2-0.4% of powder quality, obtains powder after mix homogeneously;
Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.
Advantage of the present invention is: method is simple, easy to use, can effectively suppress coccidiosis sickness rate, increases coccidiosis cure rate, avoids coccidiosis to endanger raiser in poultry process, reduces the therefore sick loss caused, is specially:
The present invention (Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae) on the basis of the common drug of control coccidiosis, further interpolation (Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Clematidis, Folium Pini, Alumen, Pericarpium Zanthoxyli), to strengthen the prevention effect of coccidiosis of going out.
Radix Dichroae, the Radix Stemonae, Fructus Bruceae, Radix Sophorae Flavescentis drive insect medicine for conventional in conventional coccidiosis medicine, the Radix Pulsatillae, Radix Scutellariae, Cortex Fraxini are dampness medicine conventional in conventional coccidiosis medicine, Herba Artemisiae Annuae, Rhizoma Imperatae, Herba Violae are heat and toxic materials clearing away medicine conventional in conventional coccidiosis medicine, Radix Codonopsis is drugs for tonifying Qi and blood conventional in conventional coccidiosis medicine, the Pseudobulbus Bletillae (Rhizoma Bletillae) is promoting blood circulation and hemostasis medicine conventional in conventional coccidiosis medicine
Active substance Shi fraxinellone main in Cortex Dictamni, has insecticidal action.The composition gossypol of Radix Gossypii has insecticidal action.The composition Chenopodium Oil of Herba Chenopodii has anthelmintic action.The atractylol of Rhizoma Atractylodis has deinsectization effect.Cimicifugine in Rhizoma Cimicifugae has deinsectization effect.The composition of Ilex purpurea Hassk.[I.chinensis Sims is Ilicis Purpureae Triterpene Glycosides, the Anemonin of Radix Clematidis or anemonol anthelmintic deinsectization, and Folium Pini contains and enriches aminoacid, blood circulation promoting, improves the function of blood capillary, improves immunity, increases hormonal secretion.The interior hemostasis of Alumen, antibacterial, external parasite killing, Pericarpium Zanthoxyli volatile oil have anthelmintic action.
detailed description of the invention:
The preparation method of chicken fowl cultivation Chinese medicine extract of the present invention, wherein, operates in accordance with the following steps:
A, spice: Chinese medicine extract mixes feedstuff, Chinese medicine extract with quality of the fodder ratio is, summer 2:100, spring and autumn 1:100, winter 0.5:100; Use one week and stop using one week, so repeatedly;
B, drinking-water: Chinese medicine extract is mixed in water and quotes for chicken fowl, is allocated as mass percent 8% summer, is allocated as mass percent 5% spring and autumn, be allocated as mass percent 2% winter; Use one week and stop using one week, so repeatedly;
C, sprinkling cage house: Chinese medicine extract is mixed in water, sprays cage house and chicken body, is allocated as mass percent 35% summer, is allocated as mass percent 20% spring and autumn, be allocated as mass percent 15% winter; Use one week and stop using one week, so repeatedly;
Steps A, B, C interval intersect or operate simultaneously;
So-called interval, for operating B after operation A, operates C after operation B, then continues from A, so repeatedly.
The while that so-called intersection being for operation A and B; Then operate C, or B and C simultaneously; Then operate A, or A and C simultaneously, then operates B;
Simultaneously so-called, refer to that ABC operates simultaneously, after stopping one week, continue ABC and operate simultaneously.
The component of described Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 50-80g of the Radix Pulsatillae, the each 40-60g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 30-50g of Herba Violae, comprise further: each 100-120g of Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, each 80-100g of Radix Clematidis, Folium Pini, each 60-80g of Pericarpium Zanthoxyli, Alumen 5-10g.
Time prepared by Chinese medicine extract, Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;
By Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Clematidis, Folium Pini, Alumen, Pericarpium Zanthoxyli, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 02-0.4% of powder quality, obtains powder after mix homogeneously;
Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.
 
Object lesson 1:
Zhong Tai plant 10000 chickens cultivate in a cage house, start to delivering for sale from chicken.Make with the following method:
A, spice: Chinese medicine extract mixes feedstuff, Chinese medicine extract with quality of the fodder ratio is, summer 2:100, spring and autumn 1:100, winter 0.5:100; Use one week and stop using one week, so repeatedly;
B, drinking-water: Chinese medicine extract is mixed in water and quotes for chicken fowl, is allocated as mass percent 8% summer, is allocated as mass percent 5% spring and autumn, be allocated as mass percent 2% winter; Use one week and stop using one week, so repeatedly;
C, sprinkling cage house: Chinese medicine extract is mixed in water, sprays cage house and chicken body, is allocated as mass percent 35% summer, is allocated as mass percent 20% spring and autumn, be allocated as mass percent 15% winter; Use one week and stop using one week, so repeatedly;
Steps A, B, C intermittently operated;
So-called interval, for operating B after operation A, operates C after operation B, then continues from A, so repeatedly.
The component of Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 80g of the Radix Pulsatillae, the each 60g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 50g of Herba Violae, comprise further: each 120g of Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, each 100g of Radix Clematidis, Folium Pini, each 80g of Pericarpium Zanthoxyli, Alumen 10g.
Time prepared by Chinese medicine extract, Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;
By Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Clematidis, Folium Pini, Alumen, Pericarpium Zanthoxyli, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 0.2-0.4% of powder quality, obtains powder after mix homogeneously;
Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.
Young chicken period coccidium infection rate 2.3%, in large chicken stage coccidium infection rate 2.1%, become chicken stage coccidium infection rate 1.8%.
 
Object lesson 2:
Kowloon, Jiangzhou Zhen Lijia plant 8000 chickens, start to delivering for sale from chicken.Make with the following method:
A, spice: Chinese medicine extract mixes feedstuff, Chinese medicine extract with quality of the fodder ratio is, summer 2:100, spring and autumn 1:100, winter 0.5:100; Use one week and stop using one week, so repeatedly;
B, drinking-water: Chinese medicine extract is mixed in water and quotes for chicken fowl, is allocated as mass percent 8% summer, is allocated as mass percent 5% spring and autumn, be allocated as mass percent 2% winter; Use one week and stop using one week, so repeatedly;
C, sprinkling cage house: Chinese medicine extract is mixed in water, sprays cage house and chicken body, is allocated as mass percent 35% summer, is allocated as mass percent 20% spring and autumn, be allocated as mass percent 15% winter; Use one week and stop using one week, so repeatedly;
Steps A, B, C interlace operation;
The while that so-called intersection being for operation A and B; Then operate C, or B and C simultaneously; Then operate A, or A and C simultaneously, then operates B; (invention be preferably steps A+B carry out simultaneously, A+B stop using one week time, operating procedure C)
The component of described Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 70g of the Radix Pulsatillae, the each 50g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 40g of Herba Violae, comprise further: each 110g of Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, each 90g of Radix Clematidis, Folium Pini, each 70g of Pericarpium Zanthoxyli, Alumen 8g.
Time prepared by Chinese medicine extract, Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;
By Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Clematidis, Folium Pini, Alumen, Pericarpium Zanthoxyli, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 02-0.4% of powder quality, obtains powder after mix homogeneously;
Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.
Young chicken period coccidium infection rate 2.1%, in large chicken stage coccidium infection rate 2.0%, become chicken stage coccidium infection rate 1.7%.
 
Example 3
Jimo Duan Bolan town cultivation basic point Mao Jia plant 6000 chickens, make with the following method from chicken to delivering for sale:
A, spice: Chinese medicine extract mixes feedstuff, Chinese medicine extract with quality of the fodder ratio is, summer 2:100, spring and autumn 1:100, winter 0.5:100; Use one week and stop using one week, so repeatedly;
B, drinking-water: Chinese medicine extract is mixed in water and quotes for chicken fowl, is allocated as mass percent 8% summer, is allocated as mass percent 5% spring and autumn, be allocated as mass percent 2% winter; Use one week and stop using one week, so repeatedly;
C, sprinkling cage house: Chinese medicine extract is mixed in water, sprays cage house and chicken body, is allocated as mass percent 35% summer, is allocated as mass percent 20% spring and autumn, be allocated as mass percent 15% winter; Use one week and stop using one week, so repeatedly;
Steps A, B, C operate simultaneously;
Simultaneously so-called, refer to that ABC operates simultaneously, after stopping one week, continue ABC and operate simultaneously.
The component of described Chinese medicine extract comprises Radix Dichroae, the Radix Stemonae, each 50-80g of the Radix Pulsatillae, the each 40-60g of Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), each 30-50g of Herba Violae, comprise further: each 100-120g of Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, each 80-100g of Radix Clematidis, Folium Pini, each 60-80g of Pericarpium Zanthoxyli, Alumen 5-10g.
Time prepared by Chinese medicine extract, Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;
By Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Clematidis, Folium Pini, Alumen, Pericarpium Zanthoxyli, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 02-0.4% of powder quality, obtains powder after mix homogeneously;
Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.
Young chicken period coccidium infection rate 2.0%, in large chicken stage coccidium infection rate 1.8%, become chicken stage coccidium infection rate 1.4%.
 
The experiment that Chinese medicine extract improves immunity is compared:
Example 1, example 2, example 3 respectively select each 30 of the chicken of identical age in days (60 age in days), as experimental group one, experimental group two, experimental group three.
Select the chicken of 60 ages in days of 30 common daily rations of feeding as a control group.The body weight gap of the chicken of three experimental grouies and matched group is less than 10g
Relatively 1 is as follows: matched group and three each Stochastic choice of experimental group 10, be placed in dark environment and exposure environment, discovery for three days on end respectively repeatedly:
Relatively 2 is as follows: remaining experimental group and matched group each 20 are merely hit, more often organize Stochastic choice 10, carries out labelling, be then placed in same environment, then drop into the sick chicken 5 suffering from coccidiosis, carries out infecting experiment, observe after 3 days.
Relatively 3 is as follows: after above-mentioned twice contrast, matched group and three experimental grouies respectively remain 10, carry out labelling, are then placed in same environment, drop into the sick chicken 5 suffering from coccidiosis again, carry out infecting experiment, after 5 days, experimental group one has 3 to catch an illness, and experimental group two has 2 to catch an illness, experimental group three has 2 to catch an illness, matched group has 7 to catch an illness, and is dissected by the sick chicken of three experimental grouies and matched group, observes, detects intestinal.
By above-mentioned contrast, can find, the incidence of three experimental grouies is obviously lighter than matched group, and matched group incidence is serious.
 
Get chicken fowl 440 plumage of 40 ages in days, weight differences is less than 10g, and be divided into 11 groups at random, often group carries out labelling, then only carries out nature with the sick chicken 100 of coccidiosis and raises together with and infect (time-division in summer)
Feed by the embodiment of the present invention 1 for 1 group, last 14 days,
Feed by the embodiment of the present invention 2 for 2 groups, last 14 days,
Feed by the embodiment of the present invention 3 for 3 groups, last 14 days,
Feed according to steps A feeding patterns in summer drinking-water of the present invention, last 14 days for 4 groups,
Feed according to step B feeding patterns in summer spice of the present invention, last 14 days for 5 groups,
6 groups are sprayed according to step C feeding patterns in summer cage house of the present invention, last 14 days,
7 groups use medicated powder of the present invention (Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae to be mixed, 120 orders are pulverized, add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, and after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder; ), water mixing is drunk, and lasts 14 days, mass percent 8%;
8 groups use medicated powder of the present invention, and medicated powder and feeding quality are than 2:100, and feeding, lasts 14 days,
9 groups use medicated powder of the present invention, the modulation quality that adds water percentage ratio 45%, spray cage house, last 14 days,
10 groups use background technologies 2013101118152 technical scheme, feeding, lasts 14 days,
11 groups use common daily forage feed, last 14 days, as a control group
Above-mentioned each group in morning on the 15th on an empty stomach, record experimental session mortality rate, all chicken fowl killed again all carries out intestinal lesion score, collects feces and carries out coccidiosis counting, weight when slaughtering.
Data target:
Mortality rate=(often group infects chicken sum in the lethal chicken number/group of coccidiosis) × 100%
Rate of body weight gain=(average weight gain of the average weight gain/matched group of each infected group) × 100%
The order of severity cuing open the intestinal of inspection after lesion score=pathological changes is scored respectively
Pathological changes value=often organizes average × 10 of experimental group lesion score
Egg capsule counting=often organize in the feces of the 7th day infecting sick chicken, multiple spot chooses fresh excreta 5g, add 10ml normal saline, stir, put into test tube with a scale and deposit 30 minutes, then add saturated aqueous common salt, do 10 times of dilutions, counting (counting is observed in Stochastic choice 5 visuals field, then averages) after mixing
Egg capsule ratio=(experimental group egg sac number/matched group egg sac number) × 100%
Egg capsule value: egg capsule is than numerical digit 0-1%, and egg capsule value is 0.
Be 5 during 2-25%
26-50% is 10
Be 20 during 51-75%
Be 40 during 76-100%
Anticoccidial Index A CI:(percentage weight increase+survival rate)-(pathological changes value+egg capsule value)
It is 120 invalid that ACI is less than or equal to,
ACI is effectively medium at 120-160
ACI is good at 160-180
ACI is outstanding when being greater than 180.
 
The results list is as follows:
By above-mentioned comparison, can find, the ACI of embodiment 1-3 is greater than 180, excellent,
Independent employing steps A, adopts separately step B, ACI to be positioned at 160-180, respond well
Independent employing step C, ACI are close to 160, effectively medium
As the medicated powder part of prior art, drinking-water and spice ACI are positioned at 120-160 interval, effectively medium.Spraying operation is less than 120, invalid.
As 2013101118152 technical schemes of prior art, ACI is positioned at 120-160 interval, effectively medium.
 
Select Chinese medicine extract of the present invention, do the experiment of toxicity to rat:
Acute oral (LD50) > 500mg/kg,
Acute percutaneous (LD50) > 2000mg/kg,
Belong to low toxicity.
 
The corresponding feed used in the present invention, in embodiment, in experimental group, matched group is as follows: (for unified experimental standard)
The field corn 55.3% of chickling, bean cake 38%, calcium hydrogen phosphate 1.4%, stone powder 1%, Sal 0.3%, oil 3%, additive 1%.The field corn 58.2% of middle chicken, bean cake 35%, calcium hydrogen phosphate 1.4%, stone powder 1.1%, Sal 0.3%, oil 3%, additive 1%.The field corn 59.2% of large chicken, Testa Tritici 2%, bean cake 22.5%, rapeseed cake 9.5%, calcium hydrogen phosphate 1.3%, stone powder 1.2%, Sal 0.3%, oil 3%, additive 1%.
 
Advantage of the present invention is: method is simple, easy to use, can effectively suppress coccidiosis sickness rate, increases coccidiosis cure rate, avoids coccidiosis to endanger raiser in poultry process, reduces the therefore sick loss caused, is specially:
The present invention (Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae) on the basis of the common drug of control coccidiosis, further interpolation (Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Clematidis, Folium Pini, Alumen, Pericarpium Zanthoxyli), to strengthen the prevention effect of coccidiosis of going out.
Radix Dichroae, the Radix Stemonae, Fructus Bruceae, Radix Sophorae Flavescentis drive insect medicine for conventional in conventional coccidiosis medicine, the Radix Pulsatillae, Radix Scutellariae, Cortex Fraxini are dampness medicine conventional in conventional coccidiosis medicine, Herba Artemisiae Annuae, Rhizoma Imperatae, Herba Violae are heat and toxic materials clearing away medicine conventional in conventional coccidiosis medicine, Radix Codonopsis is drugs for tonifying Qi and blood conventional in conventional coccidiosis medicine, the Pseudobulbus Bletillae (Rhizoma Bletillae) is promoting blood circulation and hemostasis medicine conventional in conventional coccidiosis medicine
Active substance Shi fraxinellone main in Cortex Dictamni, has insecticidal action.The composition gossypol of Radix Gossypii has insecticidal action.The composition Chenopodium Oil of Herba Chenopodii has anthelmintic action.The atractylol of Rhizoma Atractylodis has deinsectization effect.Cimicifugine in Rhizoma Cimicifugae has deinsectization effect.The composition of Ilex purpurea Hassk.[I.chinensis Sims is Ilicis Purpureae Triterpene Glycosides, the Anemonin of Radix Clematidis or anemonol anthelmintic deinsectization, and Folium Pini contains and enriches aminoacid, blood circulation promoting, improves the function of blood capillary, improves immunity, increases hormonal secretion.The interior hemostasis of Alumen, antibacterial, external parasite killing, Pericarpium Zanthoxyli volatile oil have anthelmintic action.

Claims (1)

1. a preparation method for chicken fowl cultivation Chinese medicine extract, is characterized in that, operates in accordance with the following steps:
Radix Dichroae, the Radix Stemonae, the Radix Pulsatillae, Radix Sophorae Flavescentis, Herba Artemisiae Annuae, Rhizoma Imperatae, Fructus Bruceae, Radix Scutellariae, Cortex Fraxini, Radix Codonopsis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae are mixed, 120 orders are pulverized, and add the petroleum ether reflux, extract, 3 times of 3 volume multiples, each 1 hour, filter while hot, reduced-pressure backflow petroleum ether obtains extractum, and extractum adds 8 volume multiple mass percent 80% ethanol hot melts, mass percent 2.5% active carbon reflux decolour 1 hour, be concentrated into extractum, extract dry is powder, and after sieving, ultra-vioket radiation sterilization in 5 seconds, obtains medicated powder;
By Cortex Dictamni, Radix Gossypii, Herba Chenopodii, Rhizoma Atractylodis, Rhizoma Cimicifugae, Ilex purpurea Hassk.[I.chinensis Sims, Radix Clematidis, Folium Pini, Alumen, Pericarpium Zanthoxyli, mix, with water extract method lixiviate three times, after three times lixiviating solution merges, steaming and decocting obtains mixture of viscous form, adds hydroxy methocel and correctives; The mass ratio of hydroxy methocel, correctives is 2:1, the quality of hydroxy methocel and correctives and be the 2-3% of mixture of viscous form quality, powder is obtained after drying, powder is after ultra-vioket radiation is sterilized 10 seconds, add multivitamin, the quality of the multivitamin added is the 0.2-0.4% of powder quality, obtains powder after mix homogeneously;
Medicated powder mixes according to mass ratio 3:1 with powder, obtains Chinese medicine extract after mix homogeneously.
CN201410574361.7A 2014-10-24 2014-10-24 Preparation method of traditional Chinese medicine extract for farming chicken poultry Pending CN104324300A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410574361.7A CN104324300A (en) 2014-10-24 2014-10-24 Preparation method of traditional Chinese medicine extract for farming chicken poultry

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410574361.7A CN104324300A (en) 2014-10-24 2014-10-24 Preparation method of traditional Chinese medicine extract for farming chicken poultry

Publications (1)

Publication Number Publication Date
CN104324300A true CN104324300A (en) 2015-02-04

Family

ID=52399190

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410574361.7A Pending CN104324300A (en) 2014-10-24 2014-10-24 Preparation method of traditional Chinese medicine extract for farming chicken poultry

Country Status (1)

Country Link
CN (1) CN104324300A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106561741A (en) * 2016-11-03 2017-04-19 铜陵桂生生态养殖有限公司 Disinfection spray for scorpion nests in scorpion culture

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106561741A (en) * 2016-11-03 2017-04-19 铜陵桂生生态养殖有限公司 Disinfection spray for scorpion nests in scorpion culture

Similar Documents

Publication Publication Date Title
CN102845637B (en) Chicken feed capable of preventing and treating avian influenza and Chinese herbal additive used therein
CN102150764B (en) Feed for meat ducks aged 0-21 days and preparation method thereof
CN102940155B (en) Duckling feed for cherry valley duck and preparation method thereof
CN102845638B (en) Duck feed capable of preventing and treating avian influenza and Chinese herbal additive used therein
CN104256168B (en) One boar functional feed and preparation method thereof
CN101836691B (en) Chinese medicinal herb feed additive
CN102805275B (en) Feed and traditional Chinese medicine compound used for treating colibacillosis of chicken and preparation method of feed and traditional Chinese medicine compound
CN104187172B (en) Functional feed for treating enterogastritis diseases of turtles and preparation method of functional feed
CN102961640A (en) Medicine for preventing swine foot and mouth disease and preparation method thereof
CN105166544A (en) Pig mixed feed and preparation method thereof
CN105410346A (en) Cultured penaeus vannamei survival rate improving traditional Chinese medicine preparation and preparation method thereof
CN104322891A (en) Anti-coccidiosis chicken raising method
CN104013678A (en) Traditional Chinese medicine composition for controlling avian flu and Newcastle disease and fryer culture method by using the composition
CN107998313A (en) A kind of Chinese medicine ferment for treating goat and preparation method thereof
CN104256166A (en) Functional feed for treating bovine bluetongue and preparation method thereof
CN104887890A (en) Medicine composition for treating white scour of chicken and preparation method thereof
CN104322445A (en) Broiler chicken raising method
CN106511675A (en) Medicine for preventing and treating poultry diseases and preparation method of medicine
CN104324301A (en) Anti-coccidiosis traditional Chinese medicine extract
CN104324302A (en) Preparation method of anti-coccidiosis traditional Chinese medicine extract
CN104381201A (en) Breeding method of chickens
CN104324300A (en) Preparation method of traditional Chinese medicine extract for farming chicken poultry
CN104324304A (en) Preparation method of traditional Chinese medicine extract for farming broilers
CN106071242A (en) Galenical of prevention animal (piglet) dysentery and preparation method thereof
CN106213029A (en) Broiler fodder

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150204