CN103142908B - Spray for Killing Mites on Body Surface of Pet and Preparation Method of Spray - Google Patents
Spray for Killing Mites on Body Surface of Pet and Preparation Method of Spray Download PDFInfo
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Abstract
The invention discloses a spray for killing mites on the body surface of a pet and a preparation method of the spray. The spray is simple in preparation method, convenient to use, good in curative effect and high in safety. The spray for killing the mites on the body surface of the pet is technically characterized by comprising the following ingredients in parts by weight: 75-95 parts of alcohol, 0.1-1 part of flucycloxuron, 0.1-1 part of phoxim, 5-20 parts of traditional Chinese medicine combination extracts, and 0.1-1 part of eugenol, wherein a traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-20 parts of radix stemonae, 3-5 parts of fructus cnidii, 3-5 parts of sophora flavescens, 2-4 parts of cortex phellodendri, 3-5 parts of cortex dictamni, and 4-7 parts of fructus kochiae. The spray belongs to the technical field of animal medicines.
Description
Technical field
The present invention discloses a kind of spray and preparation method thereof, specifically, is a kind of for killing spray of house pet body surface acarid and preparation method thereof, belongs to animal medicine technical field.
Background technology
Along with the raising of people's living standard, the lifting of quality of life, increasing people like pet feeding to wear down lie Fallow Time, as pet dog, pet cat, pet rabbit etc.But, between the hair of the animals such as cat and dog, easily grow dirt demodicid mite, it not only causes direct infringement to animal, but also is the communication media of some disease pathogen, by pathogen propagation to the mankind.
At present, on house pet market, the medicine of killing house pet acarid has unguentum, tablet, powder, injection, liniment, and most of medicine can not be used for Collie strain.As, organophosphorus pesticide, chrysanthemum lipid pesticide, ivermectin, doractin etc.Organophosphorus pesticide toxicity is very strong, and the toxicity such as chrysanthemum lipid pesticide, ivermectin, doractin are all less.Doractin is obtained by the new strain fermentation of Avid kyowamycin of gene recombinaton, main component is 25-hexamethylene AVERMECTIN B1, belong to novel Macrolide anti-parasite medicine, nematicide, insecticide and demodicid mite are all had and efficiently kill effect, have efficiently, consumption is little, the feature that safety range is high, generally with dosage (once amount) subcutaneous injection of 0.2mg/kg body weight, but Collie class is to this quasi drugs, easily generation is poisoning clinically.In fact, it is seldom that this single virulence factor of acarid causes that animal suffers from when acariasis, and clinical secondary antibacterial and the fungal infection often wanted is therefore single by often poor effect of antiparasitic, also can delay treatment, make substantially to transfer to chronic.In the case, generally can only be aided with again the antibiotic (intramuscular injection such as clinical conventional lincomycin, baytril, cephalosporin etc. or oral cefalexin, clavulanic acid-amoxicillin, or erythromycin, metronidazole, gentamycin liquid, Mupirocin Ointment ointment etc. are outer is coated with) and antifungal drug (local application has clotrimazole, ketoconazole, tinea clean etc., choice drug is terbinafine HCl solution, general medication has fungus No. 1, the clean oral tablets of tinea etc., also tinea body lotion is killed in available antiinflammatory) controlled.But antibiotic and antifungal drug very easily develop immunity to drugs, the general administration time of antifungal drug is also grown (2-4 week), and long term administration obviously can cause damage to the body and mind of house pet, and easily recurrence after medication.
Summary of the invention
For above-mentioned deficiency, the object of the present invention is to provide a kind of preparation method simple, easy to use, good effect, safe for killing the spray of house pet body surface acarid, the present invention also provides the preparation method of this spray.
For solving the problems of the technologies described above, last technical scheme provided by the invention is such: this is used for killing the spray of house pet body surface acarid, component by following weight parts forms: 75～95 parts of ethanol, 0.1～1 part of flucycloxuron, 0.1～1 part of phoxim, 5～20 parts of the extracts of Chinese medicine composition, 0.1～1 part of eugenol;
Wherein: described Chinese medicine composition is made up of the raw material of following weight parts: 15～20 parts of the Radixs Stemonae, 3～5 parts of Fructus Cnidiis, 3～5 parts of Radix Sophorae Flavescentiss, 2～4 parts of Cortex Phellodendris, 3～5 parts of Cortex Dictamni, 4～7 parts of the Fructus Kochiae.
Further, above-mentioned for killing the spray of house pet body surface acarid, formed by the component of following weight parts: 80～90 parts of ethanol, 0.3～0.8 part of flucycloxuron, 0.3～0.8 part of phoxim, 10～15 parts of the extracts of Chinese medicine composition, 0.3～0.8 part of eugenol;
Wherein: described Chinese medicine composition is made up of the raw material of following weight parts: 15～20 parts of the Radixs Stemonae, 3～5 parts of Fructus Cnidiis, 3～5 parts of Radix Sophorae Flavescentiss, 2～4 parts of Cortex Phellodendris, 3～5 parts of Cortex Dictamni, 4～7 parts of the Fructus Kochiae.
Further, above-mentioned for killing the spray of house pet body surface acarid, described alcoholic strength is 90.
After provided by the invention, a technical scheme is such: the preparation method of this spray, comprise the steps: successively 1) take each component by following weight portion: 75～95 parts of ethanol, 0.1～1 part of flucycloxuron, 0.1～1 part of phoxim, 5～20 parts of the extracts of Chinese medicine composition, 0.1～1 part of eugenol;
Wherein: described Chinese medicine composition is made up of the raw material of following weight parts: 15～20 parts of the Radixs Stemonae, 3～5 parts of Fructus Cnidiis, 3～5 parts of Radix Sophorae Flavescentiss, 2～4 parts of Cortex Phellodendris, 3～5 parts of Cortex Dictamni, 4～7 parts of the Fructus Kochiae.
2) extract Chinese medicine composition;
3) in the ethanol taking to step 1), add flucycloxuron, stir and dissolve completely, then adding phoxim, stir after dissolving completely, add the extract of Chinese medicine composition, after stirring, finally add eugenol, stir.
Above-mentioned for killing the preparation method of spray of house pet body surface acarid, the extracting method of the extract of described Chinese medicine composition, by the Chinese herbal medicine co-grinding taking in step 1), crosses after 30 mesh sieves, adopt Chinese herbal medicine extracting method percolation to extract, to obtain final product.
Compared with prior art, technical scheme tool provided by the invention has the following advantages: 1, product provided by the invention kills demodicid mite composition containing two kinds of high-efficiency low-toxicities, coordinates the compound formulation of Chinese herbal medicine composition.Phoxim is a kind of efficient, wide spectrum, low toxicity organophosphorus insecticide, taking tag and stomach toxicity as main, without systemic action, the power of tagging is strong, residual period, is short; It is benzene methylurea class agent for killing mite and pest that fluorine is hidden urea from, belong to chitin synthesis inhibitor, there is the features such as efficient, low toxicity, environmental friendliness, add the booster action of the Chinese herbal medicine such as the Radix Stemonae, there is instant effect, cure rate is high, and worm's ovum is also had to good inhibition growth effect, uses two kinds of insecticidal materials simultaneously, overcoming acarid easily produces drug resistance to medicine and designs, the object that increases Chinese medicinal ingredients gets final product complementary parasite killing, can treat again some senses of discomfort that acarid causes, as Pruritus; 2 pairs of Collie dogs are suitable for, safe; 3, good stability, can coordinate ivermectin class injection to be suitable for, can cross reaction, and safe and reasonable combined therapy; 5, spray design, easy to use.
Detailed description of the invention
Below in conjunction with detailed description of the invention; claim of the present invention is described in further detail; but do not form any limitation of the invention, the amendment of anyone limited number of time making in claimed range of the present invention, still within claim protection domain of the present invention.
Embodiment 1
Of the present invention a kind of for killing the spray of house pet body surface acarid, formed by the component of following weight parts: 95 parts of ethanol, 0.1 part of flucycloxuron, 1 part of phoxim, 5 parts of the extracts of Chinese medicine composition, 1 part of eugenol;
Wherein: described Chinese medicine composition is made up of the raw material of following weight parts: 15 parts of the Radixs Stemonae, 5 parts of Fructus Cnidiis, 3 parts of Radix Sophorae Flavescentiss, 4 parts of Cortex Phellodendris, 3 parts of Cortex Dictamni, 7 parts of the Fructus Kochiae
Embodiment 2
Another kind of the present invention, for killing the spray of house pet body surface acarid, is made up of the component of following weight parts: alcoholic strength is 90%(V/V) 75 parts of ethanol, 0.3 part of flucycloxuron, 0.7 part of phoxim, 10 parts of the extracts of Chinese medicine composition, 0.6 part of eugenol;
Wherein: described Chinese medicine composition is made up of the raw material of following weight parts: 20 parts of the Radixs Stemonae, 3 parts of Fructus Cnidiis, 5 parts of Radix Sophorae Flavescentiss, 2 parts of Cortex Phellodendris, 5 parts of Cortex Dictamni, 4 parts of the Fructus Kochiae.
Embodiment 3
Of the present invention also have a kind ofly for killing the spray of house pet body surface acarid, is made up of: 95 parts of ethanol, 0.7 part of flucycloxuron, 0.1 part of phoxim, 12 parts of the extracts of Chinese medicine composition, 0.1 part of eugenol the component of following weight parts;
Wherein: described Chinese medicine composition is made up of the raw material of following weight parts: 50 parts of the Radixs Stemonae, 4 parts of Fructus Cnidiis, 4 parts of Radix Sophorae Flavescentiss, 3 parts of Cortex Phellodendris, 4 parts of Cortex Dictamni, 6 parts of the Fructus Kochiae.
Embodiment 4
The present invention also has a kind of for killing the spray of house pet body surface acarid, is made up of the component of following weight parts: 85 parts of ethanol, 0.5 part of flucycloxuron, 0.5 part of phoxim, 13 parts of the extracts of Chinese medicine composition, 0.8 part of eugenol;
Wherein: described Chinese medicine composition is made up of the raw material of following weight parts: 18 parts of the Radixs Stemonae, 4 parts of Fructus Cnidiis, 3 parts of Radix Sophorae Flavescentiss, 3 parts of Cortex Phellodendris, 4 parts of Cortex Dictamni, 7 parts of the Fructus Kochiae.
Embodiment 5
Another kind of the present invention, for killing the spray of house pet body surface acarid, is made up of the component of following weight parts: 80 parts of ethanol, 0.6 part of flucycloxuron, 0.4 part of phoxim, 14 parts of the extracts of Chinese medicine composition, 0.5 part of eugenol;
Wherein: described Chinese medicine composition is made up of the raw material of following weight parts: 19 parts of the Radixs Stemonae, 5 parts of Fructus Cnidiis, 3 parts of Radix Sophorae Flavescentiss, 3 parts of Cortex Phellodendris, 4 parts of Cortex Dictamni, 6 parts of the Fructus Kochiae.
In embodiment 1 to 5, a kind of preparation method for the spray of killing house pet body surface acarid is: 1) take each component by the weight portion described in arbitrary one of embodiment 1 to 5;
2) extract Chinese medicine composition;
3) in the ethanol taking to step 1), add flucycloxuron, stir and dissolve completely, then adding phoxim, stir after dissolving completely, add the extract of Chinese medicine composition, after stirring, finally add eugenol, stir.
Wherein: the extracting method of Chinese medicine composition is to adopt percolation to extract: 1) first by the Chinese herbal medicine co-grinding taking, cross after 30 mesh sieves, in medicated powder, add ethanol (70%), the consumption lid of ethanol is crossed medicated powder 5-10m, make it abundant expansion, avoid expanding and resulting in blockage at percolator Chinese medicine powder.2) end the suitable filter material of place mat are tried to give a false impression in percolator bottom, pack the medicated powder gradation that moistening is expanded into percolator, answer degree of tightness suitable, evenly flatten, and filter paper or gauze cover for top, and add a small amount of weight, in case medicated powder floats when solubilizer.3) get rid of bubble: open the piston of percolate outlet, add solvent flow out from outlet to percolate from medicated powder top, several centimetres, solvent submergence medicated powder surface, closes percolate outlet.4) medicated powder dipping: generally carry stain 24～48h, make the abundant diffusion of solvent.5) percolation: open percolate outlet and receive the liquid of filtering, the liquid rate of outflow of filtering is calculated with 1000g medical material, conventionally continuous supplementing solvent in 1～3ml. percolation process per minute.
In the time of concrete use: by nozzle alignment skin affected part spray medicine, moistening affected part.Systemic infection vertebra back reconnaissance 3 points, every sprays 2-3 time, within 7 days, is one-period.Or abide by veterinary and advise.Within the 3-10 acarid high-incidence season, suggestion was every 15 days vertebra back reconnaissance 3-5 points, and every some spray prevents for 2-3 time.
Provide advantage of the present invention place use case of the present invention below and be explained in order better to illustrate.
Case 1
Suffer from dog: Shelties dog, female, 3 years old
Symptom: alopecia universalis is serious, ancon, ear edge are obvious, skin rubefaction, local pimple, squama, gargalesthesia is strong.
Chemical examination: acaricide +++, antibacterial+, fungus ++
Analyze the cause of disease: acaricide secondary antibacterial fungal infection
Therapeutic scheme: demodicid mite is clear, 1 times/day, directly spray serious affected part, and along vertebra reconnaissance 3-5 point, every some 3-5 spray.Be used in conjunction 7 days.After one week, depilation reduces, and skin rubefaction and pimple obviously reduce, and no longer scratch.Demodicid mite transfers clearly two days to once, is used in conjunction two weeks.Basic rehabilitation after three weeks.
Case 2
Suffer from dog: Ha Shiqi dog, female, 2 years old 5 months
Symptom: near face, elbow joint, lose hair or feathers serious, pachyderma, erythema, squama, belly is shown in pustule.
Chemical examination: vermiform mite +++, antibacterial +++
Analyze the cause of disease: vermiform mite secondary antibacterial infect
Therapeutic scheme: demodicid mite is clear, 1 times/day, directly spray serious affected part, and along vertebra reconnaissance 3-5 point, every some 3-5 spray.After being used in conjunction 3 days, transfer 1 time/2 days to.After one week, erythema and pustule obviously reduce, local scaling.Within two weeks, squama is little, no longer scratches.Basic rehabilitation after three weeks, continues to use 7 days once, and along vertebra reconnaissance 3-5 point, every some 3-5 spray, is used in conjunction consolidation in 1 month.
Case 3
Suffer from dog: Labrador Retriever, male, 2 years old 7 months
, there is red little furuncle in symptom: skin of neck is rubescent, depilation, has blister.
Chemical examination: acaricide ++, fungus ++
Analyze the cause of disease: acaricide secondary fungal infections
Therapeutic scheme: demodicid mite is clear, 1 times/day, directly spray serious affected part, and along vertebra reconnaissance 3-5 point, every some 3-5 spray.After being used in conjunction 3 days, transfer 1 time/2 days to.After one week, blister obviously reduces.Basic rehabilitation after three weeks.
Case 4
Suffer from dog: Poodle, male, 1 years old 9 months
Symptom: eyelid and around, locate to lose hair or feathers between forehead, lip, neck bottom, ancon, toe etc., bald spot, and with the slight flushing of skin, have little furuncle with it.
Chemical examination: vermiform mite ++, antibacterial ++
Analyze the cause of disease: vermiform mite secondary antibacterial infect
Therapeutic scheme: demodicid mite is clear, 1 times/day, directly spray serious affected part, and along vertebra reconnaissance 3-5 point, every some 3-5 spray.After being used in conjunction 3 days, transfer 1 time/2 days to.After one week, skin rubefaction and pimple obviously reduce, and no longer scratch.Basic rehabilitation after three weeks.
Claims (5)
1. for killing a spray for house pet body surface acarid, it is characterized in that, formed by the component of following weight parts: 75～95 parts of ethanol, 0.1～1 part of flucycloxuron, 0.1～1 part of phoxim, 5～20 parts of the extracts of Chinese medicine composition, 0.1～1 part of eugenol;
Wherein: the extract of described Chinese medicine composition is to be extracted and obtained by the component of following weight parts: 15～20 parts of the Radixs Stemonae, 3～5 parts of Fructus Cnidiis, 3～5 parts of Radix Sophorae Flavescentiss, 2～4 parts of Cortex Phellodendris, 3～5 parts of Cortex Dictamni, 4～7 parts of the Fructus Kochiae.
2. according to claim 1ly it is characterized in that for killing the spray of house pet body surface acarid, formed by the component of following weight parts: 80～90 parts of ethanol, 0.3～0.8 part of flucycloxuron, 0.3～0.8 part of phoxim, 10～15 parts of the extracts of Chinese medicine composition, 0.3～0.8 part of eugenol;
Wherein: the extract of described Chinese medicine composition is to be extracted and obtained by the component of following weight parts: 15～20 parts of the Radixs Stemonae, 3～5 parts of Fructus Cnidiis, 3～5 parts of Radix Sophorae Flavescentiss, 2～4 parts of Cortex Phellodendris, 3～5 parts of Cortex Dictamni, 4～7 parts of the Fructus Kochiae.
3. arbitrary described for killing the spray of house pet body surface acarid according to claim 1 or 2, it is characterized in that, described alcoholic strength is 90 ethanol.
4. claim 1 or 2 is arbitrary described is characterized in that for killing the preparation method of spray of house pet body surface acarid, comprises the steps: successively
1) take each component by weight portion claimed in claim 1;
2) extract Chinese medicine composition;
3) in the ethanol taking to step 1), add flucycloxuron, stir and dissolve completely, then adding phoxim, stir after dissolving completely, add the extract of Chinese medicine composition, after stirring, finally add eugenol, stir.
5. according to claim 4 for killing the preparation method of spray of house pet body surface acarid, it is characterized in that, the extracting method of the extract of described Chinese medicine composition is by the Chinese herbal medicine co-grinding taking in step 1), cross after 30 mesh sieves, adopt Chinese herbal medicine extracting method percolation to extract, to obtain final product.
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| CN106434058A (en) * | 2016-08-28 | 2017-02-22 | 骆志明 | Pure traditional Chinese medicine pet caring rebatching soap |
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| CN103920079A (en) * | 2014-04-25 | 2014-07-16 | 西南大学 | Traditional Chinese medicine composition for treating canine demodicidosis and preparation as well as preparation method and application thereof |
| CN104027342A (en) * | 2014-04-27 | 2014-09-10 | 贝嘉美（天津）生物技术研发有限公司 | Medicinal composition for preventing and treating fur animal mites |
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| CN108969710A (en) * | 2018-10-10 | 2018-12-11 | 南通季德胜科技有限公司 | It is a kind of can the antipruritic strong skin water of anti-mite and method |
| CN109122739B (en) * | 2018-10-23 | 2021-02-09 | 中国农业科学院兰州兽医研究所 | Botanical tick-killing preparation and preparation method thereof |
| CN109172741B (en) * | 2018-11-07 | 2021-04-02 | 四川维尔康动物药业有限公司 | Chinese and western compound preparation silver isatis quinome spray for preventing and treating pyoderma of pets and preparation method thereof |
| CN113952428A (en) * | 2020-07-20 | 2022-01-21 | 彭华 | External mite removing gel |
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