CN105833141A - Chinese-western compound spray for treating canine demodicosis infection and preparation method of Chinese-western compound spray for treating canine demodicosis infection - Google Patents

Chinese-western compound spray for treating canine demodicosis infection and preparation method of Chinese-western compound spray for treating canine demodicosis infection Download PDF

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CN105833141A
CN105833141A CN201610382100.4A CN201610382100A CN105833141A CN 105833141 A CN105833141 A CN 105833141A CN 201610382100 A CN201610382100 A CN 201610382100A CN 105833141 A CN105833141 A CN 105833141A
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parts
infection
western
weight
powder
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伍中杰
刘高升
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武汉中博绿亚生物科技有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/04Sulfur, selenium or tellurium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538Schizonepeta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/904Stemonaceae (Stemona family), e.g. croomia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams

Abstract

The invention discloses Chinese-western compound spray for treating canine demodicosis infection. The Chinese-western compound spray comprises, by weight, 10-30 parts of alcohol, 0.0125-0.025 part of amitraz, 2-5 parts of pesticide adjuvant 885, 65-80 parts of traditional Chinese medicine composition extract and 2-10 parts of eugeno, wherein the traditional Chinese medicine composition extract is obtained by extracting, by weight, 5-20 parts of Radix Stemonae, 3-10 parts of Herba Schizonepetae, 5-10 parts of Fructus Xanthii, 5-10 parts of Fructus Quisqualis, 2-6 parts of sulphur and 5-10 parts of Fructus Meliae Azedarach. The Chinese-western compound spray for treating canine demodicosis infection is simple in preparation method, convenient to use, remarkably effective and high in safety. The invention further provides a preparation method of the Chinese-western compound spray for treating canine demodicosis infection.

Description

一种用于治疗犬蠕形螨体感染的中西复方的喷剂及其制备方法 Western a compound for treating infection in dogs Demodex sprays and preparation method

技术领域 FIELD

[0001]本发明涉及宠物寄生虫防治技术领域,尤其涉及一种用于治疗犬蠕形螨体感染的中西复方的喷剂及其制备方法。 [0001] The present invention relates to pet parasite control technology, and in particular relates to a method for preparing spray and Western compound for treating a canine infection of Demodex.

背景技术 Background technique

[0002]养宠物成为现在的时尚,随着社会进入老龄化和人们生活水平的提高,越来越多的人们喜欢饲养宠物作为伴侣和消磨休闲时光,而宠物疾病的防治却很空白,而且宠物的品种不同,易患的疾病也有差异,如沙皮犬、北京犬、腊肠犬、斗牛犬易感染蠕形螨,并常常继发感染细菌、真菌感染,而引起更为严重的皮肤病。 [0002] pet now become fashionable, with an aging society and improve people's living standards, more and more people like to keep pets as companions and spend leisure time, and the prevention and treatment of diseases of pet very blank, and pets different varieties, there are differences in susceptibility to disease, such as Shar-Pei, Beijing, Dachshunds, Bulldogs susceptible Demodex, and often secondary bacterial infections, fungal infections, and cause more serious skin diseases. 它不仅对动物造成直接损害,而且还能将病原体传播给人类。 It not only cause direct harm to the animals, but also the spread of pathogens to humans.

[0003]犬蠕形螨目前在治疗上一般采用伊维菌素类产品进行治疗,主要以针剂为主,配合药浴进行,疗程大约需一个月以上,因此一方面比较繁琐,另一方面存在柯利犬禁用伊维菌素类,稍有不慎,就导致柯利犬类中毒,柯利犬包括苏牧、喜乐蒂、边牧、澳大利亚牧羊犬等。 [0003] Canine Demodex currently commonly used in the treatment of ivermectin treatment products, mainly in the main injection, with the medicated bath, treatment takes about a month or more, more complicated on the one hand, on the other hand the presence of Collie disabled ivermectin class, the slightest mistake, has led to poisoning dogs Collie, Collie, including Su Mu, Shetland, a Border, Australian Shepherd and so on. 也有用纯中药提取物治疗的,但效果不是很理想。 Also useful for the treatment of pure herbal extracts, but the effect is not very satisfactory.

发明内容 SUMMARY

[0004]本发明的目的是提供一种制备方法简单,使用方便,疗效好,安全性高的用于治疗犬蠕形螨感染的喷剂,本发明还提供该喷剂的制备方法。 [0004] The object of the present invention is to provide a preparation method is simple, easy, effective and safe for the treatment of infection in dogs Demodex sprays, the present invention also provides a method for preparing the sprays.

[0005]本发明的技术方案为:一种用于治疗犬蠕形螨体感染的中西复方的喷剂,由以下重量组分组成:酒精10〜30份,双甲脒0.0125〜0.025份,885农药助剂2〜5份,中药组合物的提取物65〜80份,丁香酚2〜1份; [0005] aspect of the present invention is: compound of one kind of Western spray treatment of canine Demodex for infection, the following constituents by weight: 10~30 parts alcohol, amitraz 0.0125~0.025 parts, 885 pesticide adjuvant 2 ~ 5 parts of 65~80 parts of the herbal composition extract, 2~1 parts eugenol;

[0006]其中:所述的中药组合物由下述重量份的原料经过提取得到:百部5〜20份、荆芥3〜10份、苍耳子5〜10份、使君子5〜10份、硫磺2〜6份、苦楝子5〜10份。 [0006] wherein: the herbal composition extract obtained through the following parts by weight of the starting material: one hundred parts of 5~20, 3~10 parts Nepeta, Xanthium 5 to 10 parts, 5 to 10 parts by quisqualate , 2 ~ 6 parts of sulfur, neem child 5 to 10 copies.

[0007]在上述的用于治疗犬蠕形螨体感染的中西复方的喷剂中,由以下重量份组分组成:酒精8〜25份,双甲脒0.0125〜0.025份,885农药助剂2〜5份,中药组合物的提取物65〜80份,丁香酚3〜8份; [0007] In the spray Western compound for treating dogs infected Demodex, the parts by weight of the following constituents: 8~25 parts alcohol, amitraz 0.0125~0.025 parts, 885 pesticide adjuvant 2 ~ 5 parts, the herbal composition extract parts of 65~80, 3~8 parts eugenol;

[0008]其中:所述的中药组合物由下述重量份的原料经过提取得到:百部5〜20份、荆芥3〜10份、苍耳子5〜10份、使君子5〜10份、硫磺2〜6份、苦楝子5〜10份。 [0008] wherein: the herbal composition extract obtained through the following parts by weight of the starting material: one hundred parts of 5~20, 3~10 parts Nepeta, Xanthium 5 to 10 parts, 5 to 10 parts by quisqualate , 2 ~ 6 parts of sulfur, neem child 5 to 10 copies.

[0009]在上述的用于治疗犬蠕形螨体感染的中西复方的喷剂中,所述的酒精为体积百分数为85-95%的酒精溶液。 [0009] In the spray Western compound for treating dogs infected Demodex, said alcohol is 85-95% volume percent alcohol solution.

[0010]在上述的用于治疗犬蠕形螨体感染的中西复方的喷剂中,所述的中药组合物通过渗漉法进行提取得到。 [0010] In the spray Western compound for treating dogs infected Demodex, said Chinese medicine composition obtained was extracted by percolation.

[0011]同时,本发明还公开了一种如上述的用于治疗犬蠕形螨体感染的中西复方的喷剂的制备方法,酒精中加入丁香酚,搅拌均匀后,再加入885农药助剂,搅拌均匀后,加入中药组合物的提取物,搅拌均匀后,最后加入双甲脒,搅拌均匀即可; [0011] Meanwhile, the present invention also discloses a method as described above for the preparation of Compound Western sprays canine Demodex infection treatment, eugenol alcohol was added, stirred uniformly, added 885 pesticide adjuvant after stirring well, add the herbal composition extract, after stirring uniformly, added last amitraz, mix well;

[0012]中药组合物的提取方法是采用渗漉法进行提取: [0012] Extraction of the Chinese medicinal composition is extracted using percolation method:

[0013] I)首先将称取的中草药混合粉碎,过筛后,向药粉中加入体积分数为65〜75 %的乙醇溶液,乙醇的用量盖过药粉5-1 Omm; [0013] I) to said first take herbs mixed and pulverized, sieved, added to the volume fraction of powder 65~75% ethanol solution, the amount of ethanol overshadowed powder 5-1 Omm;

[0014] 2)渗漉筒底部装假底并铺垫适宜滤材,将已润湿膨胀的药粉分次装入渗漉筒,上部用滤纸或纱布覆盖,并加少量重物,以防加溶剂时药粉浮起; When the [0014] 2) the bottom of the percolator filter pretend appropriate substrate and bedding, the wetted expanded divided powder cartridge mounted infiltration glistening, with an upper portion of a filter paper or gauze, and add a small amount of weight, solubilizers to prevent powder float;

[0015] 3)排除气泡:打开渗漉液出口的活塞,从药粉上部添加溶剂至渗漉液从出口流出,溶剂浸没药粉表面数厘米,关闭渗漉液出口; [0015] 3) to remove air bubbles: opening the piston percolate outlet, solvent is added to the powder from the upper percolate out of the outlet, the solvent immersion powder surface few centimeters off percolate outlet;

[0016] 4)药粉浸渍:提渍24〜48h,使溶剂充分渗透扩散; [0016] 4) impregnating powder: mention stains 24~48h, sufficient solvent penetration and diffusion;

[0017] 5)渗漉:打开渗漉液出口接收漉液,漉液流出速度以100g药材计算,通常每分钟I〜3ml.渗漉过程中应不断补充溶剂。 [0017] 5) percolation: percolate outlet opening receiving glistening liquid, glistening liquid medicine outflow rate calculated to 100g, typically per minute I~3ml percolation process should continue to add a solvent.

[0018]本发明的有益效果如下: [0018] Advantageous effects of the present invention are as follows:

[0019] 1、本发明走中西结合的道路,所选的杀虫药双甲脒为蠕形螨的特效药,丁香酚具有杀虫、抑菌、抗真菌作用,一方面协助双甲脒,杀灭螨虫,另一方面可以阻止因螨虫感染引起的细菌和真菌的继发性感染;所选的中草药组合,是专一针对蠕形螨筛选的中药,与双甲脒、丁香酚一起杀灭蠕形螨,以达彻底消灭,并防止其抗药性的产生。 [0019] 1, the present invention take the Chinese and Western path, selected as insecticides amitraz Demodex cure, eugenol having insecticidal, antibacterial, antifungal action, on the one hand to assist amitraz, kill mites, on the other hand prevents secondary bacterial infections caused by mites and fungal infections; herbal combination selected, is the specificity of screening for Demodex medicine, and amitraz, eugenol together kill Demodex, to achieve complete elimination of, and to prevent its development of resistance. 经临床应用,具有见效快,治愈率高,在杀灭蠕形螨的同时也防止了细菌真菌的继发性感染。 Clinical application, has a quick, high cure rate, in killing Demodex also prevents secondary infection of bacteria and fungi.

[0020] 2、特别添加885农药助剂,在提高药物疗效的同时,又可促进药物到达皮肤深层,接触螨虫而发挥作用; [0020] 2, in particular 885 pesticide additives added, while improving the drug efficacy, but also to promote the drug reaches the deep skin contacting mites play a role;

[0021] 3、本品与常规伊维菌素疗法不产生矛盾,在使用针剂伊维菌素时,可同时使用本品,以提尚疗效和缩短疗程。 [0021] 3, the product with conventional therapy is not conflict ivermectin, ivermectin injection during use, the FDA may be simultaneously, yet to provide efficacy and shorten the course.

[0022] 4、本品适用于所有的犬种,无犬品种上的禁忌。 [0022] 4, this applies to all breeds, dog breeds not contraindicated.

[0023] 5、喷剂设计,使用方便。 [0023] 5, sprays designed, easy to use.

具体实施方式 Detailed ways

[0024]下面结合具体实施方式,对本发明的技术方案作进一步的详细说明,但不构成对本发明的任何限制。 [0024] Next, with reference to specific embodiments, the technical solutions of the present invention will be described in further detail, but do not constitute any limitation of the invention.

[0025] 实施例1 [0025] Example 1

[0026]本发明的一种用于治疗犬蠕形螨感染的喷剂,由下述重量份的组分组成:酒精(90vol% )25份,双甲脒0.0125份,885农药助剂2份,中药组合物的提取物65份,丁香酚8份; [0026] A spray of the present invention is the treatment of canine Demodex infection for the parts by weight of the following components: 2 parts of alcohol (90vol%) 25 parts, 0.0125 parts amitraz, 885 pesticide adjuvant , the herbal composition extract of 65 parts, 8 parts eugenol;

[0027]其中:所述的中药组合物由下述重量份的原料组成:百部10、荆芥6份、苍耳子7份、使君子8份、硫磺4份、苦楝子7份。 [0027] wherein: said Chinese medicine composition consists of the following parts by weight of raw material composition: 10 one hundred, Nepeta parts 6, 7 parts Xanthium, Quisqualis 8 parts, 4 parts of sulfur, neem 7 sub-parts.

[0028] 实施例2 [0028] Example 2

[0029]本发明的另一种用于治疗犬蠕形螨感染的喷剂,由下述重量份的组分组成:酒精(85vol% ) 1份,双甲脒0.0175份,885农药助剂5份,中药组合物的提取物80份,丁香酚5份; [0029] Another spray for treating infections in dogs Demodex the present invention, the following parts by weight of components: Alcohol (85vol%) 1 parts, 0.0175 parts amitraz, 885 pesticide adjuvant 5 parts, the herbal composition extract of 80 parts, 5 parts of eugenol;

[0030]其中:所述的中药组合物由下述重量份的原料组成:百部5份、荆芥10份、苍耳子5份、使君子1份、硫磺2份、苦楝子1份。 [0030] wherein: said Chinese medicine composition consists of the following parts by weight of raw material composition: one hundred parts 5, Nepeta 10 parts, 5 parts Xanthium, Quisqualis 1 part 2 parts of sulfur, 1 part neem child.

[0031] 实施例3 [0031] Example 3

[0032]本发明的还有一种用于治疗犬蠕形螨感染的喷剂,由下述重量份的组分组成:酒精(95vol % ) 15份,双甲脒0.02份,885农药助剂3份,中药组合物的提取物75份,丁香酚7份; [0032] The present invention is also a spray treatment of canine Demodex infection for the parts by weight of the following components: Alcohol (95vol%) 15 parts, 0.02 parts of amitraz, 885 pesticide adjuvant 3 parts, the herbal composition extract of 75 parts, 7 parts eugenol;

[0033]其中:所述的中药组合物由下述重量份的原料组成:百部20份、荆芥3份、苍耳子5份、使君子5份、硫磺6份、苦楝子1份。 [0033] wherein: said Chinese medicine composition consists of the following parts by weight of raw material composition: 20 parts of one hundred, Nepeta 3 parts, 5 parts Xanthium, Quisqualis 5 parts, 6 parts of sulfur, 1 part neem child.

[0034] 实施例4 [0034] Example 4

[0035]本发明还有一种用于治疗犬蠕形螨感染的喷剂,由下述重量份的组分组成:酒精(90vol% )20份,双甲脒0.0125份,885农药助剂5份,中药组合物的提取物72份,丁香酚3份; [0035] Another spray treatment of canine Demodex infection for the following parts by weight of component composition of the present invention: alcohol (90vol%) 20 parts, amitraz 0.0125 parts, 5 parts 885 pesticide adjuvant , the herbal composition extract of 72 parts, 3 parts of eugenol;

[0036]其中:所述的中药组合物由下述重量份的原料组成:百部15份、荆芥5份、苍耳子10份、使君子1份、硫磺2份、苦楝子5份。 [0036] wherein: said Chinese medicine composition consists of the following parts by weight of raw material composition: 15 parts of one hundred, Nepeta 5 parts, 10 parts of fruit, the gentleman part 1, 2 parts of sulfur, 5 parts of neem child.

[0037] 实施例5 [0037] Example 5

[0038]本发明的另一种用于治疗犬蠕形螨感染的喷剂,由下述重量份的组分组成:酒精(90vol% ) 1份,双甲脒0.025份,885农药助剂4份,中药组合物的提取物80份,丁香酚6份; [0038] Another treatment Demodex infection in dogs for the spray, the following parts by weight of the constituents of the present invention: alcohol (90vol%) 1 parts 0.025 parts amitraz, 885 pesticide chemicals 4 parts, the herbal composition extract of 80 parts, 6 parts eugenol;

[0039]其中:所述的中药组合物由下述重量份的原料组成:百部20份、荆芥3份、苍耳子10份、使君子5份、硫磺6份、苦楝子5份。 [0039] wherein: said Chinese medicine composition consists of the following parts by weight of raw material composition: 20 parts of one hundred, Nepeta 3 parts, 10 parts of fruit, the gentleman 5 parts, 6 parts of sulfur, 5 parts of neem child.

[0040]实施例1至5中一种用于治疗犬蠕形螨感染的喷剂的制备方法是: [0040] Preparation Examples 1 to 5 sprays for treating infections in dogs Demodex embodiment are:

[0041] I)按实施例1至5中任一一个所述的重量份称取各个组分; [0041] I) according to Examples 1 to 5 parts by weight of any one of one of the individual components were weighed;

[0042] 2)提取中药组合物; [0042] 2) herbal composition extract;

[0043] 3)向步骤I)称取的酒精中加入丁香酚,搅拌均匀后,再加入885农药助剂,搅拌均匀后,加入中药组合物的提取物,搅拌均匀后,最后加入双甲脒,搅拌均匀即可。 [0043] 3) was weighed in Step I) was added eugenol alcohol, stir, add 885 pesticide adjuvant, stirred uniformly, added to the composition of traditional Chinese medicine extracts, stir and finally amitraz , mix well.

[0044]其中:中药组合物的提取方法是采用渗漉法进行提取:I)首先将称取的中草药混合粉碎,过30目筛后,向药粉中加入乙醇(70 % ),乙醇的用量盖过药粉5-1 Om,使之充分膨胀,避免在渗漉筒中药粉膨胀而造成堵塞。 [0044] wherein: extracting Chinese medicinal compositions are employed Percolation extraction: the I) is first called herbs taken mixed and pulverized, after through a 30 mesh sieve, ethanol was added to the powder of (70%), an amount of ethanol cover Guo powder 5-1 Om, so that fully inflated, avoiding the powder percolator expansion cause clogging. 2)渗漉筒底部装假底并铺垫适宜滤材,将已润湿膨胀的药粉分次装入渗漉筒,应松紧适宜,均匀压平,上部用滤纸或纱布覆盖,并加少量重物,以防加溶剂时药粉浮起。 2) the bottom of percolator pretend bottom and bedding suitable medium, the wetted expanded divided powder cartridge mounted infiltration Luk, should be suitably elastic, homogeneous flattened upper portion covered with gauze or filter paper, and a small amount of weight added, when solubilizers to prevent floating powder. 3)排除气泡:打开渗漉液出口的活塞,从药粉上部添加溶剂至渗漉液从出口流出,溶剂浸没药粉表面数厘米,关闭渗漉液出口。 3) remove air bubbles: percolate outlet opening piston, a solvent is added to the powder from the upper percolate out of the outlet, the solvent immersion powder surface few centimeters off percolate outlet. 4)药粉浸渍:一般提渍24〜48h,使溶剂充分渗透扩散。 4) impregnating powder: Usually mentioned stains 24~48h, sufficient solvent penetration and diffusion. 5)渗漉:打开渗漉液出口接收漉液,漉液流出速度以100g药材计算,通常每分钟I〜3ml.渗漉过程中应不断补充溶剂。 5) percolation: percolate outlet opening receiving glistening liquid, glistening liquid medicine outflow rate calculated to 100g, typically per minute I~3ml percolation process should continue to add a solvent.

[0045]在具体使用时:喷嘴对准患处,将患部喷湿,尽量不让犬舔,待自然干燥。 [0045] The specific use of: aligning the affected area of ​​the nozzle, wet the affected part, as far as possible not to lick the dog, to be naturally dried. 每隔2天,喷湿一次。 Every 2 days, once jet wet. 注意每次用药不要超过体表面积的1/3。 Note that each drug should not exceed 1/3 of body surface area. 眼睛、嘴角等敏感部位使用棉签沾药擦拭。 The sensitive parts of the eye, mouth and the like using a cotton swab to wipe drug.

[0046]为了更好的说明本发明的优点所在,下面给出本发明的使用案例予以说明。 [0046] In order to better illustrate the advantages of the present invention, where, given use case of the present invention will be described.

[0047]案例 I [0047] Case I

[0048]患犬:沙皮犬,雌性,2岁 [0048] dogs suffering: Shar Pei, female, 2 years old

[0049]症状:局部脱毛严重,肘部、耳缘明显,皮肤发红,局部变厚多皱纹,有类似糠皮样鳞肩。 [0049] Symptoms: severe localized hair removal, elbow, ear significantly, skin redness, wrinkled locally thick, similar to the shoulder bran-like scales.

[0050] 化验:纟需形蝴+++ [0050] Tests: Si need butterfly shaped +++

[0051]分析病因:蠕形螨感染 [0051] Etiology: Demodex Infection

[0052]治疗方案:伊维菌素注射I次,使用本品直接喷洒严重患处,每隔2天I次。 [0052] Treatment: I ivermectin injection times, using this direct spray severely affected area, once every 2 days I. 一周后,脱毛减少,皮肤发红明显好转。 A week later, it reduces hair removal, skin redness significant improvement. 三周后基本康复。 Basically recovered after three weeks.

[0053]案例2 [0053] Case 2

[0054]患犬:金毛,雌性,I岁5个月 [0054] suffering Dog: Golden Retriever, female, I years, 5 months

[0055]症状:近10天陆续在口角周围出现圆斑状脱毛,皮肤增厚,形成褶皱,并有丘疹出现,无痒感,有向全身扩展的趋势。 [0055] Symptoms: Over the past 10 days start to appear around the mouth round patchy hair removal, skin thickening, formation of wrinkles, and there are papules, no itching, the trend has extended to the whole body.

[0056]镜验:刮患部皮肩,或脓汁镜检发现虫体。 [0056] The lens fitting: shoulder skin scraping affected, pus or parasites found microscopic examination.

[0057] 诊断结论:婦形螨感染 [0057] Conclusion Diagnosis: mite infection in women

[0058]治疗方案:清理患部皮肩和结痂等污物后,蠕螨清,I次/2天,连用4周;伊维菌素第一天0.lmg/kg体重肌注,第二天和第三天按0.2mg/kg体重肌肉注射,以后按每天增加 [0058] Treatment: After cleaning the affected area and the shoulder skin scabs and other contaminants, Demodex mite clear, once the I / 2 days for 4 weeks; Ivermectin first day of 0.lmg / kg body weight intramuscular injection, a second day by day and 0.2mg / kg of body weight by intramuscular injection, after the increase per day

0.lmg/kg用药至0.6mg/kg时止,再隔周注射伊维菌素,用量为0.08mg/kg,期间要注意是否有中毒现象。 0.lmg / kg medication to 0.6mg / kg stop, and then every other week ivermectin injection, an amount of 0.08mg / kg, if there is to be noted that during the poisoning. 辅助用卵磷脂或不饱和脂肪酸胶囊。 Auxiliary or unsaturated fatty acid with lecithin capsules. 7周后基本康复。 7 Zhou Houji recovery.

[0059]案例3 [0059] Case 3

[0060]患犬:拉布拉多犬,雄性,7个月 [0060] dogs suffering: Labrador dog, male, 7 months

[0061]症状:眼周围脱毛,并伴以皮肤轻度潮红和发生银白色具有粘性的皮肩,皮肤显得粗糙,有龟裂现象,散布有小的结节。 [0061] Symptoms: hair removal around the eyes, and with leather shoulder to mild skin flushing and silver sticky occur, the skin appears rough, cracking phenomenon, interspersed with small nodules.

[0062]检验:切破皮肤上的结节或脓疱,取内容物涂片镜检,发现虫体。 [0062] Test: broken cut nodules or pustules on the skin, to take the contents smear found parasites.

[0063]分析病因:蠕形螨感染 [0063] Etiology: Demodex Infection

[0064]治疗方案:伊维菌素0.2mg/kg肌肉注射,隔周I次,连用4周,蠕螨清喷剂,直接喷洒严重患处,I次/2天,连用4周,皮肩减少,丘疹、水泡明显减少。 [0064] Treatment: ivermectin 0.2mg / kg intramuscularly, I every other week, once every four weeks, Demodex mite clear spray, spray severely affected part directly, I-th / 2 days, 4 weeks, to reduce skin shoulder , pimples, blisters significantly reduced. 继续使用一个月后基本康复。 A month later continued use of basic rehabilitation.

[0065]以上所述的仅为本发明的较佳实施例,凡在本发明的精神和原则范围内所作的任何修改、等同替换和改进等,均应包含在本发明的保护范围之内。 [0065] The above are merely preferred embodiments of the present invention, any modifications can be made within the spirit and principle of the present invention, equivalent replacements, improvements, etc., should be included within the scope of the present invention.

Claims (5)

1.一种用于治疗犬蠕形螨体感染的中西复方的喷剂,其特征在于,由以下重量组分组成:酒精10〜30份,双甲脒0.0125〜0.025份,885农药助剂2〜5份,中药组合物的提取物65〜80份,丁香酸2〜10份; 其中:所述的中药组合物由下述重量份的原料经过提取得到:百部5〜20份、荆芥3〜10份、苍耳子5〜1份、使君子5〜1份、硫磺2〜6份、苦楝子5〜1份。 1. A compound Western sprays for treating dogs infected Demodex, characterized in that the weight consists of the following components: parts of 10~30 alcohol, amitraz 0.0125~0.025 parts, 885 pesticide adjuvant 2 ~ 5 parts, the herbal composition extract parts of 65~80, 2~10 parts eugenol; wherein: the herbal composition extract obtained through the following parts by weight of the starting material: one hundred parts of 5~20, Nepeta 3~10 parts, fruit 5~1 parts, so that a gentleman 5~1 parts 2 ~ 6 parts of sulfur, neem son 5~1 copies.
2.根据权利要求1所述的用于治疗犬蠕形螨体感染的中西复方的喷剂,其特征在于,由以下重量份组分组成:酒精8〜25份,双甲脒0.0125〜0.025份,885农药助剂2〜5份,中药组合物的提取物65〜80份,丁香酚3〜8份; 其中:所述的中药组合物由下述重量份的原料经过提取得到:百部5〜20份、荆芥3〜10份、苍耳子5〜1份、使君子5〜1份、硫磺2〜6份、苦楝子5〜1份。 The spray Western compound of claim 1 for the treatment of infected dogs Demodex claim, characterized by the following parts by weight of components: alcohol 8~25 parts, parts amitraz 0.0125~0.025 , 885 pesticide adjuvant 2 ~ 5 parts, the herbal composition extract parts of 65~80, 3~8 parts eugenol; wherein: said Chinese medicine composition obtained by the following parts by weight of material after extraction: one hundred 5 ~ 20 copies, Nepeta 3~10 parts, fruit 5~1 parts, so that a gentleman 5~1 parts 2 ~ 6 parts of sulfur, neem son 5~1 copies.
3.根据权利要求1或2所述的用于治疗犬蠕形螨体感染的中西复方的喷剂,其特征在于,所述的酒精为体积百分数为85-95%的酒精溶液。 The spray or the compound 1 for the treatment of canine Western Demodex infection claim, wherein said alcohol is 85-95% volume percent alcohol solution.
4.根据权利要求1或2所述的用于治疗犬蠕形螨体感染的中西复方的喷剂,其特征在于,所述的中药组合物通过渗漉法进行提取得到。 The spray or the compound 1 for the treatment of canine Western Demodex infection claim, wherein said traditional Chinese medicine composition obtained by extraction percolation.
5.—种权利要求1至4任一所述的用于治疗犬蠕形螨体感染的中西复方的喷剂的制备方法,其特征在于,具体为:酒精中加入丁香酚,搅拌均匀后,再加入885农药助剂,搅拌均匀后,加入中药组合物的提取物,搅拌均匀后,最后加入双甲脒,搅拌均匀即可; 中药组合物的提取方法是采用渗漉法进行提取: 1)首先将称取的中草药混合粉碎,过筛后,向药粉中加入体积分数为65〜75%的乙醇溶液,乙醇的用量盖过药粉5-1 Omm; 2)渗漉筒底部装假底并铺垫适宜滤材,将已润湿膨胀的药粉分次装入渗漉筒,上部用滤纸或纱布覆盖,并加少量重物,以防加溶剂时药粉浮起; 3)排除气泡:打开渗漉液出口的活塞,从药粉上部添加溶剂至渗漉液从出口流出,溶剂浸没药粉表面数厘米,关闭渗漉液出口; 4)药粉浸渍:提渍24〜48h,使溶剂充分渗透扩散; 5)渗漉:打开渗漉液出口接收 5.- kinds of claims 1 to 4 to any one of the method for the preparation of Compound Western sprays dogs infected Demodex treatment, characterized in that, in particular: eugenol alcohol was added, stirred uniformly, 885 pesticide additives added, stirred uniformly, added to the composition of traditional Chinese medicine extracts, stir and finally amitraz, mix well; extracting Chinese medicinal compositions is extracted using percolation: 1) said first take herbs mixed and pulverized, sieved, added ethanol solution of 65~75% volume fraction of the powder, the amount of ethanol overshadowed powder 5-1 Omm; bottom 2) percolator pretend suitable substrate and bedding filter, the wetted expanded divided powder cartridge mounted infiltration Luk, covered with the upper filter paper or gauze, and a small amount of weight added to prevent the powder when lifting solubilizers; 3) to remove air bubbles: percolate outlet opening piston, solvent is added from the upper portion to percolate from the powder outlet to a solvent submerged powder surface few centimeters off percolate outlet; 4) impregnating powder: mention stains 24~48h, sufficient solvent penetration and diffusion; 5) percolation : Opening reception percolate outlet 漉液,漉液流出速度以100g药材计算,通常每分钟I〜3ml.渗漉过程中应不断补充溶剂。 Glistening liquid, glistening liquid medicine outflow rate calculated to 100g, typically per minute I~3ml. Percolation process should continuously add the solvent.
CN201610382100.4A 2016-06-01 2016-06-01 Chinese-western compound spray for treating canine demodicosis infection and preparation method of Chinese-western compound spray for treating canine demodicosis infection CN105833141A (en)

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