CN106728630B

CN106728630B - Antibacterial and anti-inflammatory composition and private care product

Info

Publication number: CN106728630B
Application number: CN201611199041.3A
Authority: CN
Inventors: 魏坤; 王晓慧; 秦烨芝; 胡露; 谢水林
Original assignee: Guangzhou Rui Sen Biotechnology Co ltd
Current assignee: Guangzhou Rui Sen Biotechnology Co ltd
Priority date: 2016-12-22
Filing date: 2016-12-22
Publication date: 2020-11-03
Anticipated expiration: 2036-12-22
Also published as: CN106728630A

Abstract

The invention provides an antibacterial and anti-inflammatory composition, which comprises the following components: a broad spectrum antimicrobial agent selected from chlorhexidine acetate and/or triclosan; the traditional Chinese medicine extract is selected from one or more of a first traditional Chinese medicine extract, a pomegranate bark extract and a coptis chinensis extract, and the first traditional Chinese medicine extract is selected from a cactus extract and/or an aloe extract. Compared with the prior art, the antibacterial and anti-inflammatory composition provided by the invention contains the broad-spectrum antibacterial agent and the traditional Chinese medicine extract with specific components, and the broad-spectrum antibacterial agent and the traditional Chinese medicine extract are matched to generate a synergistic effect, so that the composition has good antibacterial and anti-inflammatory effects; moreover, the antibacterial and anti-inflammatory composition provided by the invention contains traditional Chinese medicine components, and is safe, mild and non-irritant. The invention also provides a personal care product.

Description

Antibacterial and anti-inflammatory composition and private care product

Technical Field

The invention relates to the technical field of antibacterial care products, in particular to an antibacterial and anti-inflammatory composition and a private care product.

Background

The social responsibility and the living pressure of modern women are increased sharply, so that the modern women have to face a fast-paced life style, are in offices, on the way to work and on business trip most of the time, and are easily infected by bacteria in public places. The female external genitalia organ has a complex structure, is adjacent to the urethra and the anus, and the weak private parts are easy to be infected with various germs to cause gynecological diseases such as vaginitis, cervicitis, pelvic inflammation and the like. The gynecological diseases threaten the health of women in China and are in a trend of youth, relevant data of health departments in China show that the incidence rate of the gynecological diseases of women of childbearing age is over 70 percent, the morbidity rate is in an obvious rising trend, almost 100 percent of women have vaginitis with different degrees in life, and more than 4 hundred million women in China need gynecological medicines. The special physiological structure of the private parts of the male also can easily store dirt and lead to various symptoms such as skin diseases, tumor itching, inflammation and the like. The inflammation of private parts seriously affects the daily work and life of people, endangers the physical and mental health of people, and even causes some women to be infertility, so the daily cleaning and nursing of the private parts cannot be ignored.

Many women are convenient to figure, and when the vulva is cleaned, the acidic environment of the vulva can be damaged by using common cleaning products such as bath cream or perfumed soap, the pH value of the vagina can be changed, the flora imbalance can be caused, the local resistance can be reduced, and gynecological diseases can be induced. Therefore, the private care product is an essential article for female life, and can be used by men to prevent diseases. The existing private care products can play a cleaning role, but have poor effects on inhibiting and killing harmful bacteria and balancing private physiological environment.

Disclosure of Invention

In view of the above, the invention aims to provide an antibacterial and anti-inflammatory composition and a private care product, and the private care product prepared from the antibacterial and anti-inflammatory composition provided by the invention has good cleaning, sterilizing and anti-inflammatory effects.

The invention provides an antibacterial and anti-inflammatory composition, which comprises the following components:

a broad spectrum antimicrobial agent selected from chlorhexidine acetate and/or triclosan;

the traditional Chinese medicine extract is selected from one or more of a first traditional Chinese medicine extract, a pomegranate bark extract and a coptis chinensis extract, and the first traditional Chinese medicine extract is selected from a cactus extract and/or an aloe extract.

Preferably, the herbal extract is selected from the group consisting of cactus extract, pomegranate rind extract and coptis chinensis extract.

Preferably, the water chestnut peel extract, the prinsepia utilis royle extract and the blackberry lily extract are also included.

Preferably, the composition also comprises one or more of a polygonum hydropiper extract, a spreading hedyotis herb extract and a poplar flower extract.

Preferably, the composition also comprises a polygonum hydropiper extract, a spreading hedyotis herb extract and a poplar flower extract.

Preferably, the antibacterial and anti-inflammatory composition comprises:

chlorhexidine acetate, cactus extract, pomegranate bark extract, coptis extract, water chestnut bark extract, prinsepia utilis royle extract, blackberry lily extract, polygonum hydropiper extract, oldenlandia diffusa extract and poplar flower extract.

The invention provides a private care product, which comprises the antibacterial and anti-inflammatory composition in the technical scheme.

Preferably, the method further comprises the following steps: one or more of film forming agent, pH regulator, humectant, solubilizer, foaming agent and algefacient.

Preferably, the liquid soap also comprises a film forming agent, a pH value regulator, a humectant, a solubilizer, a foaming agent, a freshener and water.

Compared with the prior art, the antibacterial and anti-inflammatory composition provided by the invention contains the broad-spectrum antibacterial agent and the traditional Chinese medicine extract with specific components, and the broad-spectrum antibacterial agent and the traditional Chinese medicine extract are matched to generate a synergistic effect, so that the composition has good antibacterial and anti-inflammatory effects; moreover, the antibacterial and anti-inflammatory composition provided by the invention contains traditional Chinese medicine components, and is safe, mild and non-irritant.

The antibacterial and anti-inflammatory composition provided by the invention is used for a private care product, and the private care product can effectively clean private parts, inhibit the growth and reproduction of pathogenic bacteria in the private parts, and play a good role in sterilizing, diminishing inflammation, relieving itching and removing peculiar smell. The private part care product provided by the invention can balance acid-base and flora environments, effectively prevent private part diseases from generating and relapse, and can be used for daily cleaning and can be used by both men and women. In addition, the private part care product provided by the invention is safe, mild and non-irritant, and has the efficacy of assisting in beautifying the private part after long-term use.

The invention preferably prepares the private care product into the no-clean mousse product, and the no-clean mousse product can be directly sprayed when in use, does not need to be diluted and washed by water and is convenient to use.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the present invention, the broad spectrum antimicrobial agent is preferably chlorhexidine acetate. In the present invention, the chinese herbal medicine extract is preferably selected from the group consisting of a first chinese herbal medicine extract, a pomegranate bark extract and a coptis chinensis extract. In the present invention, the first herbal extract is preferably a cactus extract. In the present invention, the antibacterial and anti-inflammatory composition preferably includes chlorhexidine acetate, cactus extract, pomegranate bark extract, and coptis extract. The broad-spectrum antibacterial agent and the traditional Chinese medicine extract in the antibacterial and anti-inflammatory composition provided by the invention have a synergistic effect when used together, preferably the synergistic effect of chlorhexidine acetate, cactus extract, pomegranate bark extract and coptis chinensis extract, so that the antibacterial and anti-inflammatory composition has good antibacterial and anti-inflammatory effects.

In the invention, the mass ratio of the broad-spectrum antibacterial agent to the traditional Chinese medicine extract is preferably (0.1-0.3): (2.6-6.5), more preferably (0.15-0.25): (3-6), most preferably 0.2: (4-5). In the invention, the mass ratio of the first traditional Chinese medicine extract to the pomegranate bark extract to the coptis chinensis extract is preferably (0.6-1): (1-2.5): (1-3), more preferably (0.7-0.9): (1.5-2): (1.5 to 2.5), most preferably 0.8: (1.7-1.8) 2.

In the invention, the antibacterial and anti-inflammatory composition preferably further comprises one or more of a water chestnut peel extract, a prinsepia utilis royle extract and a blackberry lily extract, and more preferably further comprises a water chestnut peel extract, a prinsepia utilis royle extract and a blackberry lily extract. In the present invention, the antibacterial and anti-inflammatory composition preferably includes: chlorhexidine acetate, cactus extract, pomegranate bark extract, coptis extract, water chestnut bark extract, prinsepia utilis royle extract and blackberry lily extract. In the invention, the water chestnut peel extract, the prinsepia utilis royle extract and the blackberry lily extract can generate a synergistic effect with the spectral antibacterial agent and the traditional Chinese medicine extract in the technical scheme, so that the antibacterial and anti-inflammatory effects of the antibacterial and anti-inflammatory composition are further improved.

In the invention, the mass ratio of the broad-spectrum antibacterial agent to the water chestnut peel extract is preferably (0.1-0.3): (1-3), more preferably (0.15-0.25): (1.5 to 2.5), and most preferably 0.2:2. In the invention, the mass ratio of the broad-spectrum antibacterial agent to the prinsepia utilis royle extract is preferably (0.1-0.3): (1-2.5), more preferably (0.15-0.25): (1.5-2), most preferably 0.2 (1.7-1.8). In the invention, the mass ratio of the broad spectrum antibacterial agent to the blackberry lily extract is preferably (0.1-0.3): (1-3), more preferably (0.15-0.25): (1.5 to 2.5), and most preferably 0.2:2.

In the invention, the antibacterial and anti-inflammatory composition preferably further comprises one or more of a polygonum hydropiper extract, a spreading hedyotis herb extract and a poplar flower extract, and more preferably further comprises the polygonum hydropiper extract, the spreading hedyotis herb extract and the poplar flower. In the present invention, the antibacterial and anti-inflammatory composition preferably includes: chlorhexidine acetate, cactus extract, pomegranate bark extract, coptis extract, water chestnut bark extract, prinsepia utilis royle extract, blackberry lily extract, polygonum hydropiper extract, oldenlandia diffusa extract and poplar flower extract. In the invention, the polygonum hydropiper extract, the spreading hedyotis herb extract and the poplar flower extract can generate synergistic effect with the spectral antibacterial agent and the traditional Chinese medicine extract, the water chestnut peel extract, the prinsepia utilis royle extract and the blackberry lily extract in the technical scheme, so that the antibacterial and anti-inflammatory effects of the antibacterial and anti-inflammatory composition are further improved.

In the invention, the mass ratio of the broad-spectrum antibacterial agent to the polygonum hydropiper extract is preferably (0.1-0.3): (0.5-2), more preferably (0.15-0.25): (1-1.5), and most preferably 0.2 (1.2-1.3). In the present invention, the mass ratio of the broad spectrum antibacterial agent to the oldenlandia diffusa extract is preferably (0.1-0.3): (0.5-2), more preferably (0.15-0.25): (1-1.5), and most preferably 0.2 (1.2-1.3). In the invention, the mass ratio of the broad-spectrum antibacterial agent to the poplar flower extract is preferably (0.1-0.3): (1-4), more preferably (0.15-0.25): (2-3), and most preferably 0.2: 2.5.

The invention provides a personal care product, which comprises the antibacterial and anti-inflammatory composition in the technical scheme, preferably further comprises one or more of a film forming agent, a pH value regulator, a humectant, a solubilizer, a foaming agent and a freshener, and more preferably further comprises the film forming agent, the pH value regulator, the humectant, the solubilizer, the foaming agent, the freshener and water. The invention preferably prepares the personal care product into a no-clean mousse formulation, generates foam without friction when in use, sprays the foam immediately, does not need to be diluted and washed by water, and is convenient to use.

In the invention, the mass content of the antibacterial and anti-inflammatory composition in the personal care product is preferably 7.7-23.3%, more preferably 10-20%, more preferably 12-18%, and most preferably 14-16%. In the invention, the mass content of the film forming agent in the personal care product is preferably 0.1-0.3%, more preferably 0.15-0.25%, and most preferably 0.2%. In the invention, the mass content of the pH value regulator in the personal care product is preferably 2.4-4.4%, more preferably 3-4%, more preferably 3.2-3.8%, and most preferably 3.4-3.6%. In the invention, the mass content of the moisturizer in the personal care product is preferably 3-7%, more preferably 4-6%, and most preferably 5%. In the invention, the mass content of the solubilizer in the personal care product is preferably 2.3-8.9%, more preferably 3-8%, more preferably 4-7%, and most preferably 5-6%. In the invention, the mass content of the foaming agent in the personal care product is preferably 3-8%, more preferably 4-7%, and most preferably 5-6%. In the present invention, the cooling agent is preferably present in the personal care product in an amount of 0.03 to 0.07%, more preferably 0.04 to 0.06%, and most preferably 0.05% by mass. In the present invention, the amount of water is: the total mass content of the personal care product is 100%, and the residual mass content is the mass content of water after the sum of the mass contents of the antibacterial and anti-inflammatory composition, the film forming agent, the pH value regulator, the humectant, the solubilizer, the foaming agent and the freshener in the personal care product is removed.

In the invention, the film forming agent is preferably selected from one or more of methyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose and xanthan gum, more preferably methyl cellulose, and can form a protective film on the surface of the skin of the personal care product. In the invention, the pH value regulator is preferably selected from one or more of triethanolamine, lactic acid, citric acid, phosphoric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium lactate and sodium citrate, and more preferably triethanolamine, lactic acid and sodium citrate, and can enable the private care product to form a weakly acidic buffer solution, help to maintain an acidic environment, promote the growth of beneficial bacteria, inhibit harmful bacteria, and enable the film forming agent to be better dissolved in an alkaline environment in the process of preparing the private care solution. In the invention, the mass ratio of the triethanolamine to the lactic acid to the sodium citrate is preferably (1-1.8): (1-2): (0.4-0.6), more preferably (1.2-1.6): (1.2-1.8): (0.45-0.55), most preferably (1.4-1.5): (1.4-1.6): 0.5.

in the present invention, the humectant is preferably selected from one or more of glycerin, propylene glycol, butylene glycol, sorbitol, tremella polysaccharide, panthenol, niacinamide, and ceramide, and more preferably glycerin and tremella polysaccharide. In the invention, the mass ratio of the glycerol to the tremella polysaccharide is preferably (3-7): (0.5 to 1), more preferably (4 to 6): (0.6 to 0.9), most preferably 5: (0.7-0.8).

In the present invention, the solubilizer is preferably selected from one or more of ethanol, butyether and hydrogenated castor oil, more preferably from one or more of ethanol, PPG-26-butyether-26 and PEG-40 hydrogenated castor oil, and most preferably from ethanol, PPG-26-butyether-26 and PEG-40 hydrogenated castor oil, and the solubilizer enables the bactericide and the cooling agent to be more easily dissolved in the aqueous phase. In the invention, the mass ratio of the ethanol to the PPG-26-butanol polyether-26 to the PEG-40 hydrogenated castor oil is preferably (2-8): (0.1-0.3): (0.2 to 0.6), more preferably (3 to 7): (0.15-0.25): (0.3 to 0.5), most preferably (4 to 6): 0.2: 0.4.

in the invention, the foaming agent is selected from one or more of phosphate ester salt, alkyl glycoside, sarcosinate, cocamidopropyl betaine, sodium lauroyl glutamate, soapberry fruit extract and soapbark extract, and is more preferably sodium lauroyl glutamate and soapberry fruit extract. In the invention, the mass ratio of the sodium lauroyl glutamate to the soapberry fruit extract is preferably (2-4): (1-4), more preferably (2.5-3.5): (2-3), and most preferably 3: 2.5.

In the present invention, the cooling agent is preferably selected from menthol and/or borneol, more preferably menthol.

In the present invention, the intimate care product preferably comprises: methyl cellulose, triethanolamine, glycerol, chlorhexidine acetate, ethanol, menthol, PPG-26-butanol polyether-26, PEG-40 hydrogenated castor oil, lactic acid, sodium citrate, sodium lauroyl glutamate, soapberry fruit extract, cactus extract, polygonum hydropiper extract, pomegranate rind extract, oldenlandia diffusa extract, eleocharis tuberosa peel extract, prinsepia utilis royle extract, coptis chinensis extract, poplar flower extract, blackberry lily extract and water. In the present invention, the intimate care product more preferably comprises: 0.1 to 0.3 wt% of methyl cellulose; 1-1.8 wt% triethanolamine; 3-7% by weight of glycerol 3-7%; 0.1-0.3 wt% of chlorhexidine acetate; 2-8 wt% ethanol; 0.03-0.07 wt% of menthol; 0.1-0.3 wt% of PPG-26-butanol polyether-26; 0.2-0.6 wt% of PEG-40 hydrogenated castor oil; 1-2 wt% of lactic acid; 0.4-0.6 wt% of sodium citrate; 2-4 wt% of sodium lauroyl glutamate; 1-4 wt% of soapberry fruit extract; 0.6-1 wt% of cactus extract; 0.5-2 wt% of polygonum hydropiper extract, 1-2.5 wt% of pomegranate peel extract, 0.5-2 wt% of oldenlandia diffusa extract, 1-3 wt% of water chestnut peel extract, 1-2.5 wt% of prinsepia utilis royle extract, 1-3 wt% of coptis chinensis extract, 1-4 wt% of poplar flower extract, 1-3 wt% of blackberry lily extract and the balance of deionized water.

In the invention, the sodium lauroyl glutamate has strong foaming performance, mild cleaning and moistening effects, safe use and no influence on the environment. Sapindus mukurossi extract has effects of clearing heat, eliminating phlegm, removing food stagnation and killing parasites, and is mainly used for treating dyspepsia, leucorrhea, malnutritional stagnation, sore tinea and pyogenic infections. Contains soapberry saponin, is a natural surfactant, has rich foam, fine hand feeling, strong detergency and environmental protection, and has the effects of resisting bacteria, beautifying, sterilizing, diminishing inflammation, removing dandruff, relieving itching, tendering skin, whitening, removing spots, removing acne, preventing and treating skin diseases and the like. Chlorhexidine acetate, also called chlorhexidine acetate, has extremely strong broad-spectrum antibacterial and bactericidal effects and low toxicity, can be used for treating various inflammations such as vaginitis, cervical erosion, leukorrhagia and the like caused by pathogens such as gonorrhea, trichomonas, and the like, is also used for cleaning and health-care medicines before reinspection, before and after abortion, before and after sexual intercourse and after childbirth, and is often reasonably matched with traditional Chinese medicine extracts to prepare a female lotion or a care solution. The cactus extract has the effects of clearing away heat and toxic materials, removing blood stasis, relieving swelling, invigorating stomach, relieving pain, relieving cough, resisting inflammation, resisting allergy, lowering blood sugar, reducing blood lipid, lowering blood pressure, resisting oxidation, resisting tumor, and enhancing immunity. Herba Polygoni Hydropiperis extract has effects of removing toxic substance, eliminating dampness, stopping bleeding, activating stagnancy, dispelling pathogenic wind, relieving itching and detumescence, and can be used for treating acute filthy disease abdominal pain, vomiting and diarrhea, spasm, diarrhea, dysentery, rheumatism, loempe, carbuncle, scabies, and traumatic injury. Pomegranate rind extract has the functions of relieving diarrhea with astringents, stopping bleeding and expelling parasites. It is commonly used for chronic diarrhea, chronic dysentery, hematochezia, rectocele, metrorrhagia, leukorrhagia, abdominal pain due to parasitic infestation. Mainly contains tannin, flavonoid and glucoside thereof, alkaloid, organic acid and the like, and has the functions of resisting virus, broad-spectrum bacteria, tumors, oxidation, cardiovascular and cerebrovascular diseases, regulating immunity and protecting stomach. Herba Hedyotidis Diffusae extract has effects of clearing heat, promoting diuresis, and removing toxic substance, and can be used for treating lung heat cough and asthma, tonsillitis, pharyngolaryngitis, appendicitis, dysentery, jaundice, pelvic inflammatory disease, adnexitis, carbuncle, furuncle, etc. The water chestnut peel extract can clear heat, promote salivation, eliminate dampness, dispel cold, stimulate appetite, promote digestion, improve eyesight, clear voice and sober up, is suitable for symptoms such as phlegm-heat cough, fever polydipsia, sore throat, aphtha of the mouth and tongue, scanty and brownish urine, dyspepsia and the like, contains the antibacterial component water chestnut English, and has the effects of resisting oxidation, bacteria, tumors, promoting bowel movement, relaxing bowels, inducing diuresis, discharging stranguria and the like. The Prinsepia utilis Royle extract has effects of clearing heat, removing toxic substances, promoting blood circulation, removing blood stasis, tonifying deficiency, relieving inflammation, detumescence, relieving pain, resolving food stagnation, invigorating stomach, etc. The coptis extract has the effects of clearing heat and drying dampness, purging fire and removing toxicity, and is used for treating damp-heat fullness, vomiting and acid regurgitation, dysentery, jaundice, high fever and coma, hyperactivity of heart-fire, vexation and insomnia, blood heat and hematemesis and epistaxis, conjunctival congestion, toothache, thirst, carbuncle swelling and furuncle and the like, and can be externally used for treating eczema, eczema and pyorrhea in ear canals. The poplar flower extract has the functions of clearing away heat and toxic material, eliminating dampness, strengthening spleen and nourishing stomach, eliminating dampness and relieving dysentery, and has the functions of resisting bacteria, resisting tumor, relieving fever and pain, resisting inflammation, resisting rheumatism and the like. Belamcanda chinensis extract has effects of clearing heat and detoxicating, removing toxic substance and relieving sore throat, clearing heat and eliminating phlegm, and clearing heat and resolving hard mass, and is mainly used for treating pharyngitis and pharyngalgia, cough and adverse rising of qi, excessive phlegm, scrofula tuberculosis, malarial malaria, amenorrhea of women, carbuncle swelling and sore toxicity. Has antiinflammatory, dermatophytosis inhibiting, antibacterial, antiviral, cholagogue, and antiallergic effects.

In the present invention, the method of preparing the intimate care product preferably comprises the steps of:

(1) adding a film forming agent and a pH value regulator (alkaline) into hot water for mixing to obtain a first mixed solution;

(2) mixing the humectant, the broad-spectrum antibacterial agent, the solubilizer and the freshener to obtain a second mixed solution;

(3) adding the second mixed solution into the first mixed solution to obtain a first mixture;

(4) adding a pH value regulator (acidity) into the mixture and mixing to obtain a second mixture;

(5) and adding a foaming agent and the traditional Chinese medicine extract into the second mixture in sequence, and mixing to obtain the personal care product.

In the invention, in the step (1), preferably, the film forming agent is added into hot water at 90 ℃, stirred until the film forming agent is clear and bright, and then the alkaline pH value regulator is added and stirred uniformly to obtain a first mixed solution.

In the present invention, the mixing in the step (2) is preferably stirred until complete dissolution. In the present invention, the mixing in the step (4) is preferably stirred uniformly. In the present invention, the mixing in the step (5) is preferably stirred uniformly.

In the present invention, the film forming agent, pH adjuster, humectant, broad-spectrum antibacterial agent, solubilizer, freshener, foaming agent, and herbal extract and their amounts are the same as those of the above technical solutions, and are not repeated herein.

In the invention, the preparation methods of the polygonum hydropiper extract, the pomegranate bark extract and the oldenlandia diffusa extract are preferably as follows:

crushing dried polygonum hydropiper, pomegranate rind and oldenlandia, weighing the medicinal powder, adding 50-80% ethanol water solution with the mass concentration of 6-10 times of the mass of the medicinal powder, and soaking for 30-60 min; then refluxing for 2-3 times at 60-75 ℃ for 2-3 h each time, combining the extracting solutions, recovering ethanol, concentrating under reduced pressure to 1-1.05 g (crude drug)/mL to obtain each medicinal material extracting solution, and refrigerating at 4 ℃ for later use.

In the invention, the preparation method of the water chestnut peel extract is preferably as follows:

crushing dried water chestnut peels, weighing the medicinal powder, adding 50-90% ethanol aqueous solution which is 6-10 times of the weight of the medicinal powder, leaching for 10-14 hours at 35-40 ℃, filtering to obtain supernatant, then carrying out reduced pressure distillation, concentrating to 1-1.05 g (crude drug)/mL, and refrigerating at 4 ℃ for later use.

In the invention, the preparation method of the prinsepia utilis royle extract, the coptis chinensis extract, the poplar flower extract and the blackberry lily extract is preferably as follows:

crushing dried prinsepia utilis royle, coptis chinensis, poplar flowers and blackberrykiky rhizome, weighing the medicinal material powder, adding distilled water with the mass 6-10 times of that of the medicinal material powder, soaking for 30-60 min, decocting for 2-3 times at 60-85 ℃, filtering for 1-2 h each time, combining filtrates, concentrating under reduced pressure to 1-1.05 g (crude drug)/mL to obtain each medicinal material extracting solution, and refrigerating at 4 ℃ for later use.

The invention preferably prepares the private part care product into the no-clean type pudendum cleaning mousse according to the method of the technical scheme, the no-clean type pudendum cleaning mousse is safe, mild and non-irritant, can effectively clean private parts, balance acid-base and flora environments, inhibit the growth and reproduction of pathogenic bacteria at the private parts, simultaneously has the functions of cooling, refreshing, sterilizing, diminishing inflammation, relieving itching and removing peculiar smell, is convenient to use, can be sprayed, and does not need to be diluted and washed by water. The invention has the efficacy of assisting in beautifying the private parts and can effectively prevent the occurrence and recurrence of private diseases after being used for a long time, and is suitable for both men and women.

The starting materials used in the following examples of the present invention are all commercially available products.

Example 1

The preparation method of the polygonum hydropiper extract, the pomegranate bark extract and the oldenlandia diffusa extract comprises the following steps: pulverizing dried herba Polygoni Hydropiperis, pericarpium Granati, and herba Hedyotidis Diffusae, respectively weighing 100g of the above medicinal materials powder, adding 65% ethanol water solution 8 times the weight of the medicinal materials powder, soaking for 45min, refluxing at 70 deg.C for 2 times, each time for 3 hr, mixing extractive solutions, recovering ethanol, concentrating under reduced pressure to 1g (crude drug)/mL to obtain each medicinal material extractive solution, and refrigerating at 4 deg.C for use.

The preparation method of the water chestnut peel extracting solution comprises the following steps: pulverizing dried corm Eleocharitis peel, weighing 100g of medicinal powder, adding 50% ethanol water solution 10 times of the medicinal powder, extracting at 40 deg.C for 14 hr, filtering to obtain supernatant, distilling under reduced pressure, concentrating to 1.03g (crude drug)/mL, and refrigerating at 4 deg.C for use.

The preparation method of the prinsepia utilis royle extract, the coptis chinensis extract, the poplar flower extract and the blackberry lily extract comprises the following steps: pulverizing dried Prinsepia utilis Royle, Coptidis rhizoma, poplar flower, and rhizoma Belamcandae, respectively weighing 100g of the above medicinal materials powder, adding 6 times of distilled water, soaking for 60min, decocting at 60 deg.C for 3 times, each for 1 hr, filtering, mixing filtrates, concentrating under reduced pressure to 1.03g (crude drug)/mL to obtain medicinal material extractive solution, and refrigerating at 4 deg.C for use.

Formula of the personal care product: 0.1 wt% of methylcellulose, 1.8 wt% of triethanolamine, 7 wt% of glycerol, 0.3 wt% of chlorhexidine acetate, 2 wt% of ethanol, 0.07 wt% of menthol, 0.3 wt% of PPG-26-butyl polyether-260.3 wt% of PEG-40 hydrogenated castor oil, 2 wt% of lactic acid, 0.4 wt% of sodium citrate, 4 wt% of sodium lauroyl glutamate, 1 wt% of soapberry fruit extract, 1 wt% of cactus extract, 0.5 wt% of polygonum hydropiper extract, 2.5 wt% of pomegranate peel extract, 2 wt% of oldenlandia diffusa extract, 1 wt% of chufa peel extract, 2.5 wt% of prinsepia utilis royle extract, 1 wt% of coptis chinensis extract, 1 wt% of poplar flower extract, 3 wt% of blackberry lily extract and the balance of water.

The preparation method of the personal care product comprises the following steps:

1) adding methyl cellulose into hot water with the temperature of more than 90 ℃, continuously stirring until the mixture is clear and transparent, then adding triethanolamine, and uniformly stirring;

2) mixing glycerol, chlorhexidine acetate, ethanol, menthol, PPG-26-butanol polyether-26 and PEG-40 hydrogenated castor oil, stirring until completely dissolved, and transferring into the water solution obtained in the step 1);

3) adding lactic acid and sodium citrate, and stirring uniformly;

4) sequentially adding sodium lauroyl glutamate, fructus Sapindi Mukouossi extract, radix et caulis Opuntiae Dillenii extractive solution, herba Polygoni Hydropiperis extractive solution, pericarpium Granati extractive solution, herba Hedyotidis Diffusae extractive solution, corm Eleocharitis bark extractive solution, fructus Prinsepiae utilis extractive solution, Coptidis rhizoma extractive solution, poplar flower extractive solution, and rhizoma Belamcandae extractive solution, and stirring.

Example 2

The preparation method of the polygonum hydropiper extract, the pomegranate bark extract and the oldenlandia diffusa extract comprises the following steps: pulverizing dried herba Polygoni Hydropiperis, pericarpium Granati, and herba Hedyotidis Diffusae, respectively weighing 100g of the above medicinal materials powder, adding 80% ethanol water solution 6 times the weight of the medicinal materials powder, soaking for 60min, refluxing at 75 deg.C for 2 times, each time for 2 hr, mixing extractive solutions, recovering ethanol, concentrating under reduced pressure to 1.05g (crude drug)/mL to obtain each medicinal material extractive solution, and refrigerating at 4 deg.C for use.

The preparation method of the water chestnut peel extracting solution comprises the following steps: pulverizing dried corm Eleocharitis peel, weighing 100g of medicinal powder, adding 70% ethanol water solution 8 times the weight of the medicinal powder, extracting at 35 deg.C for 12 hr, filtering to obtain supernatant, distilling under reduced pressure, concentrating to 1g (crude drug)/mL, and refrigerating at 4 deg.C for use.

The preparation method of the prinsepia utilis royle extract, the coptis chinensis extract, the poplar flower extract and the blackberry lily extract comprises the following steps: pulverizing dried Prinsepia utilis Royle, Coptidis rhizoma, poplar flower, and rhizoma Belamcandae, respectively weighing 100g of the above medicinal powder, adding distilled water 8 times the weight of the medicinal powder, soaking for 45min, decocting at 85 deg.C for 2 times, each for 2 hr, filtering, mixing filtrates, concentrating under reduced pressure to 1g (crude drug)/mL to obtain medicinal extractive solution, and refrigerating at 4 deg.C for use.

The formula of the private part care product is as follows: 0.2 wt% of methylcellulose, 1.4 wt% of triethanolamine, 5 wt% of glycerol, 0.2 wt% of chlorhexidine acetate, 5 wt% of ethanol, 0.05 wt% of menthol, 0.2 wt% of PPG-26-butanol polyether-260.2 wt% of PEG-40 hydrogenated castor oil, 1.5 wt% of lactic acid, 0.5 wt% of sodium citrate, 3 wt% of sodium lauroyl glutamate, 2.5 wt% of soapberry extract, 0.8 wt% of cactus extract, 1.25 wt% of polygonum hydropiper extract, 1.75 wt% of pomegranate bark extract, 1.25 wt% of spreading hedyotis herb extract, 2 wt% of water chestnut bark extract, 1.75 wt% of prinsepia utilis royle extract, 2 wt% of coptis chinensis extract, 2.5 wt% of poplar extract, 2 wt% of blackberry lily extract and the balance of water.

The personal care product was prepared as in example 1.

Example 3

The preparation method of the polygonum hydropiper extract, the pomegranate bark extract and the oldenlandia diffusa extract comprises the following steps: pulverizing dried herba Polygoni Hydropiperis, herba Hedyotidis Diffusae, and pericarpium Granati, respectively weighing 100g of the above medicinal materials powder, adding 10 times of 50% ethanol water solution, soaking for 30min, refluxing at 60 deg.C for 3 times, each time for 2 hr, mixing extractive solutions, recovering ethanol, concentrating under reduced pressure to 1.03g (crude drug)/mL to obtain each medicinal material extractive solution, and refrigerating at 4 deg.C for use.

The preparation method of the water chestnut extracting solution comprises the following steps: pulverizing dried corm Eleocharitis peel, weighing 100g of medicinal powder, adding 90% ethanol water solution 6 times the weight of the medicinal powder, extracting at 35 deg.C for 10 hr, filtering to obtain supernatant, distilling under reduced pressure, concentrating to 1.05g (crude drug)/mL, and refrigerating at 4 deg.C for use.

The preparation method of the prinsepia utilis royle extract, the coptis chinensis extract, the poplar flower extract and the blackberry lily extract comprises the following steps of: pulverizing dried Prinsepia utilis Royle, Coptidis rhizoma, poplar flower, and rhizoma Belamcandae, respectively weighing 100g of the above medicinal materials powder, adding 10 times of distilled water, soaking for 30min, decocting at 75 deg.C for 3 times, each for 2 hr, filtering, mixing filtrates, concentrating under reduced pressure to 1.05g (crude drug)/mL to obtain medicinal material extractive solution, and refrigerating at 4 deg.C for use.

The formula of the private part care product is as follows: 0.3 wt% of methylcellulose, 1 wt% of triethanolamine, 3 wt% of glycerol, 0.1 wt% of chlorhexidine acetate, 8 wt% of ethanol, 0.03 wt% of menthol, 0.1 wt% of PPG-26-butyl polyether, 0.2 wt% of PEG-40 hydrogenated castor oil, 1 wt% of lactic acid, 0.6 wt% of sodium citrate, 2 wt% of sodium lauroyl glutamate, 4 wt% of soapberry fruit extract, 0.6 wt% of cactus extract, 0.5 wt% of polygonum hydropiper extract, 1 wt% of pomegranate peel extract, 0.5 wt% of oldenlandia diffusa extract, 3 wt% of chufa peel extract, 1 wt% of prinsepia utilis royle extract, 3 wt% of coptis chinensis extract, 4 wt% of poplar flower extract, 1 wt% of blackberry lily extract and the balance of water.

The personal care product was prepared as in example 1.

Example 4

The formula and preparation method of the private part care product are the same as those in example 3, except that no polygonum hydropiper extract, oldenlandia diffusa extract, water chestnut peel extract, prinsepia utilis royle extract, poplar flower extract and blackberry lily extract are used, and the amount of the cactus extract is 4.6 wt%, the amount of the pomegranate peel extract is 5 wt%, and the amount of the coptis extract is 5 wt%.

Example 5

The formula and preparation method of the private part care product are the same as those in example 3, except that no polygonum hydropiper extract, oldenlandia diffusa extract and poplar flower extract are used, and the amount of the cactus extract is 2.6 wt%, the amount of the pomegranate peel extract is 2.4 wt%, the amount of the coptis chinensis extract is 2.4 wt%, the amount of the water chestnut peel extract is 2.4 wt%, the amount of the prinsepia utilis royle extract is 2.4 wt%, and the amount of the blackberry lily extract is 2.4 wt%.

Comparative example 1

The formula and preparation method of the personal care product were the same as in example 3 except that the herbal extract was not used and the amount of the broad-spectrum antimicrobial agent was 0.3 wt%.

Example 6 in vitro antibacterial Performance test

Clinical isolated strains of staphylococcus aureus, escherichia coli and candida albicans are respectively cultured in a culture medium, the private care products prepared in examples 1-5 and comparative example 1 are taken as test objects, the operation is carried out according to the national standard GB15979-2002, the results are shown in table 1, and the table 1 is the in vitro antibacterial performance test results of the private care products prepared in examples 1-5 and comparative example 1 of the invention.

TABLE 1 in vitro antibacterial Performance test results for Care in private parts products prepared according to examples 1-5 of the present invention and comparative example 1

As can be seen from Table 1, the product for caring private parts provided by the invention has significant antibacterial activity against common pathogenic bacteria of private parts, such as Staphylococcus aureus, Escherichia coli and Candida albicans, and can maintain the balance of private flora.

Example 7 irritation test on vaginal mucosa

12 common-grade female New Zealand rabbits with the weight of 2-2.5 kg are randomly divided into 4 groups, the experimental group is the private care product prepared in the embodiment 1-3 of the invention, the control group is sterilized normal saline, 3 animals are respectively used, and the vaginal orifice of the animal is checked for secretion, congestion, edema and other conditions before the experiment. Fixing the animal on the back, exposing the vaginal opening, wetting the catheter with normal saline, gently inserting the catheter into the vagina (4-5 cm), slowly injecting 2mL of test object with an injector, and withdrawing the catheter to finish the contamination. After 24 hours, the animals were sacrificed by air embolism, the vagina was completely cut off and longitudinally incised, and the presence of congestion, edema and the like was visually observed. The results show that: the vaginal mucosa of each group of experimental animals has no congestion, edema and erosion, and the irritation index of the vaginal mucosa is less than 1, so that the private care product provided by the invention has no irritation to the vaginal mucosa.

Example 8 clinical efficacy testing

360 women are selected and divided into 4 groups at the age of 25-55, wherein each group comprises 30 bacterial vaginosis, 30 trichomonas vaginalis and 30 comprehensive vaginalis, and 3 groups respectively use the private care products prepared in the embodiments 1-3, the using method comprises the steps of pumping a proper amount of the private care products to be gentle for 1-3 minutes, the other group uses metronidazole cleaning solution as a control group and is continuously used for 30 days, the test results are shown in a table 2, and the table 2 is the clinical effect test result of the private care products prepared in the embodiments 1-3.

TABLE 2 clinical results of testing the efficacy of the personal care products prepared in examples 1-3 of the present invention

As can be seen from Table 2, the effect of the product for caring private parts provided by the invention is remarkable and is obviously higher than that of a control group, and the product can effectively prevent the occurrence and recurrence of private diseases.

As can be seen from the above examples, the present invention provides an antibacterial and anti-inflammatory composition comprising: a broad spectrum antimicrobial agent selected from chlorhexidine acetate and/or triclosan; the traditional Chinese medicine extract is selected from one or more of a first traditional Chinese medicine extract, a pomegranate bark extract and a coptis chinensis extract, and the first traditional Chinese medicine extract is selected from a cactus extract and/or an aloe extract. The antibacterial and anti-inflammatory composition provided by the invention is used for a private care product, and the private care product can effectively clean private parts, inhibit the growth and reproduction of pathogenic bacteria in the private parts, and play a good role in sterilizing, diminishing inflammation, relieving itching and removing peculiar smell. The private part care product provided by the invention can balance acid-base and flora environments, effectively prevent private part diseases from generating and relapse, and can be used for daily cleaning and can be used by both men and women. In addition, the private part care product provided by the invention is safe, mild and non-irritant, and has the efficacy of assisting in beautifying the private part after long-term use. The invention preferably prepares the private care product into the no-clean mousse product, and the no-clean mousse product can be directly sprayed when in use, does not need to be diluted and washed by water and is convenient to use.

Claims

1. An antimicrobial and anti-inflammatory personal care product comprising the following components:

0.1 to 0.3 wt% of methyl cellulose; 1-1.8 wt% triethanolamine; 3-7% by weight of glycerol 3-7%; 0.1-0.3 wt% of chlorhexidine acetate; 2-8 wt% ethanol; 0.03-0.07 wt% of menthol; 0.1-0.3 wt% of PPG-26-butanol polyether-26; 0.2-0.6 wt% of PEG-40 hydrogenated castor oil; 1-2 wt% of lactic acid; 0.4-0.6 wt% of sodium citrate; 2-4 wt% of sodium lauroyl glutamate; 1-4 wt% of soapberry fruit extract; 0.6-1 wt% of cactus extract; 0.5-2 wt% of polygonum hydropiper extract, 1-2.5 wt% of pomegranate peel extract, 0.5-2 wt% of oldenlandia diffusa extract, 1-3 wt% of water chestnut peel extract, 1-2.5 wt% of prinsepia utilis royle extract, 1-3 wt% of coptis chinensis extract, 1-4 wt% of poplar flower extract, 1-3 wt% of blackberry lily extract and the balance of deionized water.