CN106580791B - Antibacterial composition and private care product - Google Patents
Antibacterial composition and private care product Download PDFInfo
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- CN106580791B CN106580791B CN201611207178.9A CN201611207178A CN106580791B CN 106580791 B CN106580791 B CN 106580791B CN 201611207178 A CN201611207178 A CN 201611207178A CN 106580791 B CN106580791 B CN 106580791B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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Abstract
The present invention provides an antimicrobial composition comprising: cactus extract, coptis root extract and angelica extract. The invention provides a personal care product comprising the antimicrobial composition. The effective components of the antibacterial composition provided by the invention are traditional Chinese medicine extracts, and the antibacterial composition is mild and non-irritant, and the cactus extract, the coptis extract and the angelica extract are mutually matched to have a synergistic effect, so that the antibacterial composition has a good bactericidal effect. The antibacterial composition provided by the invention is used for preparing the private part care product, and the antibacterial composition does not contain a chemical bactericide and has a good bactericidal effect, so that the prepared private part care product is safe, mild and non-irritant, can effectively clean private parts, balance acid-base and flora environments, inhibit the growth and reproduction of pathogenic bacteria in the private parts, and simultaneously has the effects of sterilizing, diminishing inflammation, relieving itching and removing peculiar smell.
Description
Technical Field
The invention relates to the technical field of skin care, in particular to an antibacterial composition and a private care product.
Background
The social responsibility and the living pressure of modern women are increased sharply, and people have to face a fast-paced life style, most of the time is in offices, on the way to work and on business, and more of the time is in public places. Moreover, the female external genitalia organ has a complex structure, is adjacent to the urethra and the anus, and the weak private parts are easy to be infected with various germs, so that gynecological diseases such as vaginitis, cervicitis, pelvic inflammation and the like are caused. The gynecological diseases threaten the health of women in China and are in a trend of youth, and relevant data of health departments in China show that the incidence rate of the gynecological diseases of women in childbearing age in China is over 70 percent, the morbidity rate is in an obvious rising trend, almost 100 percent of women in lifetime have vaginitis with different degrees, and more than 4 hundred million women in China need gynecological medicines. The special physiological structure of the private parts of the male also can easily store dirt and lead to various symptoms such as skin diseases, tumor itching, inflammation and the like. The inflammation of private parts seriously affects the daily work and life of people and endangers the physical and mental health of people, and even some women are infertility, so the daily cleaning and nursing of the private parts cannot be ignored.
Many women are convenient in drawing, and when the vulva is cleaned, the acidic environment of the vulva is damaged by using common cleaning products such as bath cream or perfumed soap, the pH value of the vagina is changed, the flora is disordered, the local resistance is reduced, and gynecological diseases are induced. Therefore, the private care product is an indispensable cleaning product for female life, and the male can also use the product to prevent the occurrence of diseases. At present, the sterilization function of private articles is mainly realized by adding chemical bactericides, such as dodecyl dimethyl benzyl ammonium bromide or 2,4,4 '-trichloro-2' -hydroxydiphenyl ether, and the like, the chemical products have large irritation to the skin of the female private part, can generate drug resistance after long-term use, easily damage the physiological environment of the female private part, cause bacterial colony disorder and generate focus. Therefore, the development of a cleaning and nursing product which is mild and non-irritant, can effectively clean the private parts, inhibits and kills harmful bacteria and balances the physiological environment of the private parts has important significance.
Disclosure of Invention
In view of the above, the invention aims to provide an antibacterial composition, and a private care product prepared from the antibacterial composition provided by the invention does not contain a chemical bactericide, is mild and non-irritant, and can effectively inhibit and kill harmful bacteria.
The present invention provides an antimicrobial composition comprising:
cactus extract, coptis root extract and angelica extract.
Preferably, the method further comprises the following steps:
one or more of herba Hedyotidis Diffusae extract, herba Polygoni Hydropiperis extract and Perillae herba extract.
Preferably, the method further comprises the following steps:
herba Hedyotidis Diffusae extract, herba Polygoni Hydropiperis extract and Perillae herba extract.
Preferably, the method further comprises the following steps:
one or more of radix Isatidis extract, Prinsepia utilis Royle extract and herba Violae extract.
Preferably, the method further comprises the following steps:
radix Isatidis extract, Prinsepia utilis Royle extract, and herba Violae extract.
Preferably, the antimicrobial composition comprises:
cactus extract, coptis chinensis extract, angelica sinensis extract, oldenlandia diffusa extract, polygonum hydropiper extract, perilla extract, isatis root extract, prinsepia utilis royle extract and Chinese violet extract.
The invention provides a personal care product, which comprises the antibacterial composition in the technical scheme.
Preferably, the method further comprises the following steps:
thickening agent, solvent, surfactant, foam stabilizer, preservative, stabilizer and/or acidity regulator.
Preferably, the surfactant is an amino acid surfactant.
Preferably, the method further comprises the following steps: pearlescent flakes and/or preservative enhancers.
Compared with the prior art, the effective components of the antibacterial composition provided by the invention are traditional Chinese medicine extracts, do not contain chemical bactericides, are mild and have no stimulation, and the cactus extract, the coptis extract and the angelica extract are matched with each other to have a synergistic effect, so that the antibacterial composition has a good bactericidal effect.
The antibacterial composition provided by the invention is used for preparing the private part care product, and the antibacterial composition does not contain a chemical bactericide and has a good bactericidal effect, so that the prepared private part care product is safe, mild and non-irritant, can effectively clean private parts, balance acid-base and flora environments, inhibit the growth and reproduction of pathogenic bacteria in the private parts, and simultaneously has the effects of sterilizing, diminishing inflammation, relieving itching and removing peculiar smell.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The present invention provides an antimicrobial composition comprising:
cactus extract, coptis root extract and angelica extract.
In the invention, the mass ratio of the cactus extract to the coptis root extract to the angelica sinensis extract is preferably (0.5-2): (1-3): (1-4), more preferably (1-1.5): (1.5-2.5): (2-3), most preferably (1.2-1.3): 2: 2.5.
the antibacterial composition provided by the invention preferably further comprises one or more of a ophioglossum extract, a polygonum hydropiper extract and a perilla extract, more preferably further comprises several of the ophioglossum hydropiper extract, the polygonum hydropiper extract and the perilla extract, and most preferably further comprises the ophioglossum hydropiper extract, the polygonum hydropiper extract and the perilla extract. In the invention, the mass ratio of the ophioglossus niveus extract to the polygonum hydropiper extract to the perilla frutescens extract is preferably (0.5-2) to (0.5-2): (1-2.5), more preferably (1-1.5) and (1-1.5): (1.5-2), most preferably (1.2-1.3) and (1.2-1.3): (1.7-1.8). In the invention, the mass ratio of the cactus extract to the oldenlandia diffusa extract is preferably (0.5-2): (0.5-2), more preferably (1-1.5): (1-1.5), most preferably (1.2-1.3): (1.2-1.3). In the present invention, the antibacterial composition preferably includes: cactus extract, coptis root extract, angelica extract, oldenlandia diffusa extract, polygonum hydropiper extract and perilla extract. According to the invention, the hedyotis diffusa extract, the polygonum hydropiper extract and the perilla extract can further generate a synergistic effect with the cactus extract, the coptis extract and the angelica extract in the technical scheme, so that the sterilization effect of the antibacterial composition is improved.
The antibacterial composition provided by the invention preferably further comprises one or more of radix isatidis extract, prinsepia utilis royle extract and Chinese violet extract, more preferably further comprises several of radix isatidis extract, prinsepia utilis royle extract and Chinese violet extract, and most preferably further comprises radix isatidis extract, prinsepia utilis royle extract and Chinese violet extract. In the invention, the mass ratio of the isatis root extract, the prinsepia utilis royle extract and the philippine violet herb extract is preferably (1-3) to (1-2.5): (1 to 3), more preferably (1.5 to 2.5) to (1.5 to 2): (1.5-2.5), most preferably 2 (1.7-1.8): 2. in the invention, the mass ratio of the cactus extract to the isatis root extract is preferably (0.5-2): (1-3), more preferably (1-1.5): (1.5-2.5), most preferably (1.2-1.3): 2. in the invention, the radix isatidis extract, the prinsepia utilis royle extract and the Chinese violet extract can further generate synergistic effect with the cactus extract, the coptis chinensis extract, the Chinese angelica extract, the ophiorrhiza pumila extract, the polygonum hydropiper extract and the perilla extract in the technical scheme, so that the sterilization effect of the antibacterial composition is further improved.
In the present invention, the antibacterial composition more preferably comprises: cactus extract, coptis chinensis extract, angelica sinensis extract, oldenlandia diffusa extract, polygonum hydropiper extract, perilla extract, isatis root extract, prinsepia utilis royle extract and Chinese violet extract. In the invention, the mass ratio of the cactus extract, the coptis chinensis extract, the angelica sinensis extract, the oldenlandia diffusa extract, the polygonum hydropiper extract, the perilla extract, the isatis root extract, the prinsepia utilis royle extract and the philippine violet herb extract is preferably (0.5-2): (1-3): (1-4): (0.5-2) and (0.5-2): (1-2.5): (1-3) in (1-2.5): (1-3), more preferably (1-1.5): (1.5-2.5): (2-3): (1-1.5) in (1-1.5): (1.5-2): (1.5-2.5) in the following ratio (1.5-2): (1.5-2.5), most preferably (1.2-1.3): 2: 2.5: (1.2-1.3) in the following ratio (1.2-1.3): (1.7-1.8): 2, (1.7-1.8): 2.
the invention provides a personal care product, which comprises the antibacterial composition in the technical scheme. In the present invention, the intimate care product preferably further comprises one or more of a thickener, a solvent, a surfactant, a foam stabilizer, a preservative, a stabilizer, and an acidity regulator, more preferably further comprises several of a thickener, a solvent, a surfactant, a foam stabilizer, a preservative, a stabilizer, and an acidity regulator, and most preferably further comprises a thickener, a solvent, a surfactant, a foam stabilizer, a preservative, a stabilizer, and an acidity regulator. In the present invention, the intimate care product preferably further comprises a pearlescent flake and/or a preservative synergist, more preferably further comprises a pearlescent flake and a preservative synergist.
In the present invention, the intimate care product preferably comprises: the antibacterial composition comprises an antibacterial composition, a thickening agent, a solvent, a surfactant, a foam stabilizer, a preservative, a stabilizer, an acidity regulator, a pearlescent sheet, a preservative synergist and water.
In the invention, the mass content of the antibacterial composition in the personal care product is preferably 7.5-24%, more preferably 10-20%, more preferably 12-18%, and most preferably 14-16%. In the present invention, the antibacterial composition is the same as the antibacterial composition in the above technical scheme, and is not described herein again.
In the invention, the mass content of the thickening agent in the personal care product is preferably 1-3%, more preferably 1.5-2.5%, and most preferably 2%. In the present invention, the thickener has a thickening effect, and can grow a surfactant micelle and increase the viscosity. In the present invention, the thickener is preferably selected from sodium chloride and/or potassium chloride, more preferably sodium chloride.
In the invention, the mass content of the solvent in the personal care product is preferably 6-12%, more preferably 8-10%, and most preferably 9%. In the present invention, the solvent is preferably selected from glycerol and/or sorbitol, more preferably glycerol.
In the present invention, the surfactant is preferably present in the personal care product in an amount of 20 to 35% by mass, more preferably 25 to 30% by mass, most preferably 27 to 28% by mass. In the present invention, the surfactant is preferably an amino acid surfactant, more preferably sodium lauroyl glutamate and/or cocamidopropyl betaine, most preferably sodium lauroyl glutamate and cocamidopropyl betaine. In the invention, the mass ratio of the sodium lauroyl glutamate to the cocamidopropyl betaine is preferably (8-19): (10-16), more preferably (10-16): (12-14), most preferably 18:10, 19:16 or 8: 12.
In the invention, the mass content of the foam stabilizer in the personal care product is preferably 1.5-2.5%, more preferably 1.8-2.2%, and most preferably 2%. In the present invention, the foam stabilizer is preferably one or more selected from lauric acid, myristic acid, palmitic acid and stearic acid, and more preferably lauric acid.
In the invention, the mass content of the preservative in the personal care product is preferably 0.2-0.5%, and more preferably 0.3-0.4%. In the invention, the preservative is preferably one or more selected from phenoxyethanol, chlorphenesin, caprylhydroxamic acid, p-hydroxyacetophenone and hydroxyphenylpropionamide benzoic acid, and is more preferably phenoxyethanol and chlorphenesin. In the invention, the mass ratio of phenoxyethanol to chlorphenesin is preferably (0.1-0.3): (0.1 to 0.2), more preferably (0.15 to 0.25): (0.12 to 0.18), most preferably 0.2: (0.14-0.16).
In the invention, the mass content of the stabilizer in the personal care product is preferably 0.5-2.5%, more preferably 1-2%, more preferably 1.2-1.8%, and most preferably 1.4-1.6%. In the present invention, the stabilizer has a suspension stabilizing effect. In the present invention, the stabilizer is preferably an acrylic copolymer, which is a copolymer of acrylic acid, methacrylic acid and/or one or more simple esters thereof, is a commonly used additive in the art for preparing skin care products, and is commercially available.
In the invention, the content of the acidity regulator in the personal care product is preferably 0.4-0.8% by mass, more preferably 0.5-0.7% by mass and most preferably 0.6% by mass. In the present invention, the acidity regulator is preferably citric acid or lactic acid.
In the invention, the mass content of the pearly-lustre sheet in the personal care product is preferably 1-3%, more preferably 1.5-2.5%, and most preferably 2%. In the invention, the pearly-lustre sheet can generate obvious pearly-lustre effect for private care products. In the invention, the pearlized sheet is preferably one or more of ethylene glycol distearate and ethylene glycol monostearate, and is more preferably ethylene glycol distearate.
In the invention, the content of the preservative synergist in the personal care product is preferably 0.1-0.3%, more preferably 0.15-0.25%, and most preferably 0.2%. In the invention, the antiseptic synergist is preferably selected from one or more of ethylhexyl glycerol, octyl glycol, 1, 2-pentanediol and 1, 2-hexanediol, and is more preferably ethylhexyl glycerol.
The water is not particularly limited in the present invention, and is preferably deionized water. In the invention, the water is used in an amount of 100% of the total mass content of the components in the personal care product, and the mass content of the antibacterial composition, the thickening agent, the solvent, the surfactant, the foam stabilizer, the preservative, the stabilizer, the acidity regulator, the pearlescent sheet and the preservative synergist is the sum of the mass contents of the antibacterial composition, the thickening agent, the solvent, the surfactant, the foam stabilizer, the preservative, the acidity regulator, the pearlescent sheet and the preservative synergist.
In the present invention, the intimate care product preferably comprises: sodium chloride, glycerol, amino acid surfactant, ethylene glycol distearate, lauric acid, acidity regulator, acrylic acid (ester) copolymer, cactus extract, polygonum hydropiper extract, perilla extract, oldenlandia diffusa extract, isatis root extract, prinsepia utilis royle extract, coptis chinensis extract, angelica sinensis extract, philippine violet herb extract, ethylhexyl glycerol, phenoxyethanol, chlorphenesin and water; more preferably, it comprises: 1-3 wt% of sodium chloride, 6-12 wt% of glycerol, 20-35 wt% of amino acid surfactant, 2 wt% of ethylene glycol distearate, 1.5-2.5 wt% of lauric acid, 0.4-0.8 wt% of acidity regulator, 0.5-2.5 wt% of acrylic acid (ester) copolymer, 0.5-2 wt% of cactus extract, 0.5-2 wt% of polygonum hydropiper extract, 1-2.5 wt% of perilla extract, 0.5-2 wt% of oldenlandia diffusa extract, 1-3 wt% of isatis root extract, 1-2.5 wt% of prinsepia utilis royle extract, 1-3 wt% of coptis chinensis extract, 1-4 wt% of angelica sinensis extract, 1-3 wt% of philippine violet herb extract, 0.1-0.3 wt% of ethylhexyl glycerol, 0.1-0.3 wt% of phenoxyethanol, 0.1-0.2 wt% of chlorphenesin and the balance of water.
The preparation method of the personal care product is not particularly limited, and the person skilled in the art can prepare the required dosage form of the personal care product by adding appropriate components by adopting the antibacterial composition as an antibacterial component according to actual needs. In the present invention, the method of preparing the intimate care product preferably comprises the steps of:
(1) mixing water, a surfactant, a thickening agent and a solvent to obtain a first mixture;
(2) mixing a surfactant, a pearlescent sheet, a stabilizer, an acidity regulator and the first mixture to obtain a second mixture;
(3) mixing the antimicrobial composition with the second mixture to obtain a mixed solution;
(4) dissolving a stabilizer in water, and mixing with the mixed solution to obtain a third mixture;
(5) and mixing the third mixture with a preservative synergist and a preservative to obtain the personal care product.
In the present invention, the antibacterial composition, the thickener, the solvent, the surfactant, the foam stabilizer, the preservative, the stabilizer, the acidity regulator, the pearlescent sheet, the preservative synergist and water and the amounts thereof are the same as those of the antibacterial composition, the thickener, the solvent, the surfactant, the foam stabilizer, the preservative, the stabilizer, the acidity regulator, the pearlescent sheet, the preservative synergist and water and the amounts thereof in the above technical solutions, and are not described herein again.
In the invention, the mixing temperature in the step (1) is preferably 80-85 ℃, and the time is preferably 10-15 min. In the present invention, the surfactant in the step (1) is preferably sodium lauroyl glutamate. In the present invention, the surfactant in the step (2) is preferably cocamidopropyl betaine. In the present invention, the mixing temperature in the step (3) is preferably 60 to 65 ℃. In the present invention, the mixing temperature in the step (5) is preferably 40 to 45 ℃.
In the invention, the preparation methods of the polygonum hydropiper extract, the oldenlandia diffusa extract, the angelica sinensis extract and the Chinese violet herb extract are preferably as follows:
crushing dried polygonum hydropiper, oldenlandia diffusa, angelica sinensis and Chinese violet, respectively weighing the medicinal material powder, adding 50-80% ethanol water solution with the mass concentration of 6-10 times of the mass of the medicinal material powder, soaking for 30-60 min, refluxing for 2-3 times at 60-75 ℃, 2-3 h each time, combining extracting solutions, recovering ethanol, concentrating under reduced pressure to 1-1.05 g (crude drug)/mL to obtain each medicinal material extract, and refrigerating at 4 ℃ for later use.
In the invention, the preparation methods of the perilla extract, the isatis root extract, the prinsepia utilis royle extract and the coptis extract comprise the following steps:
crushing dried perilla, isatis root, prinsepia utilis royle and coptis, weighing the medicinal material powder, adding distilled water with the mass 6-10 times of that of the medicinal material powder, soaking for 30-60 min, decocting for 2-3 times at 60-85 ℃ for 1-2 h each time, filtering, combining filtrates, concentrating under reduced pressure to 1-1.05 g (crude drug)/mL to obtain each medicinal material extract, and refrigerating at 4 ℃ for later use.
In the invention, the sodium lauroyl glutamate has strong foaming performance, mild cleaning and moistening effects, safe use and no influence on the environment. The cocamidopropyl betaine has the advantages of small irritation, biodegradability, good cleaning, foaming and conditioning effects, excellent compatibility and thickening performance, and certain antibacterial and antibacterial effects. The cactus extract has the effects of clearing away heat and toxic materials, removing blood stasis, relieving swelling, invigorating stomach, relieving pain, relieving cough, resisting inflammation, resisting allergy, lowering blood sugar, reducing blood lipid, lowering blood pressure, resisting oxidation, resisting tumor, and enhancing immunity. Herba Polygoni Hydropiperis extract has effects of removing toxic substance, eliminating dampness, stopping bleeding, activating stagnancy, dispelling pathogenic wind, relieving itching and detumescence, and can be used for treating acute filthy disease abdominal pain, vomiting and diarrhea, spasm, diarrhea, dysentery, rheumatism, loempe, carbuncle, scabies, and traumatic injury. Perilla extract has effects of relieving exterior syndrome, dispelling cold, descending qi, eliminating phlegm, moistening lung, relieving constipation, promoting urination, stopping cholera, resolving stagnation, preventing miscarriage, regulating blood lipid, resisting oxidation, and resisting bacteria. The herba Hedyotidis Diffusae extract has effects of clearing heat, promoting diuresis, and removing toxic substance, and can be used for treating lung heat cough and asthma, tonsillitis, pharyngolaryngitis, appendicitis, dysentery, jaundice, pelvic inflammatory disease, adnexitis, carbuncle, furuncle, etc. The isatis root extract has the effects of clearing away heat and toxic materials, cooling blood and relieving sore throat, and is used for treating diseases such as warm-toxicity spots, deep-red dark, mumps, pharyngitis, erysipelas, major head plague, erysipelas, carbuncle and the like. The Prinsepia utilis Royle extract has effects of clearing heat, removing toxic substances, promoting blood circulation, removing blood stasis, tonifying deficiency, relieving inflammation, detumescence, relieving pain, resolving food stagnation, invigorating stomach, etc. The coptis extract has the effects of clearing heat and drying dampness, purging fire and removing toxicity, and is used for treating damp-heat fullness, vomiting and acid regurgitation, dysentery, jaundice, high fever and coma, hyperactivity of heart-fire, vexation and insomnia, blood heat and hematemesis and epistaxis, conjunctival congestion, toothache, thirst, carbuncle swelling and furuncle and the like, and can be externally used for treating eczema, eczema and pyorrhea in ear canals. The angelica extract has the effects of enriching blood and activating blood, regulating menstruation and relieving pain, relaxing bowel, blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, amenorrhea and dysmenorrheal, deficiency cold and abdominal pain, intestinal dryness and constipation, rheumatic arthralgia, traumatic injury, carbuncle, cellulitis, sore and ulcer and the like, is commonly used by doctors and is called as 'ten prescriptions and nine guizi', and the angelica has the effects of reducing blood pressure, easing pain, resisting inflammation, resisting bacteria, resisting radiation, resisting injury, enhancing immune function, resisting oxidation, clearing free radicals and the like. The herba violae extract has the effects of clearing away heat and toxic materials, cooling blood, relieving swelling and diminishing inflammation, and is used for treating furuncle pyogenic infections, carbuncle, cellulitis, carbuncle on the back, erysipelas, venomous snake bite, damp-heat jaundice and other diseases.
The invention selects the mild amino acid surfactant and the traditional Chinese medicine extract to prepare the private part care product by reasonable matching, the private part care product can effectively clean the private part, is safe and non-irritant, can not damage the skin mucous membrane of the private part, can adjust the environmental balance of acid, alkali and flora of the private part, inhibits the breeding of staphylococcus aureus, escherichia coli and candida albicans, has the functions of sterilizing, diminishing inflammation, relieving itching and removing peculiar smell, can not generate drug resistance after being used for a long time, not only has the effect of assisting in beautifying the private part, but also can effectively prevent the occurrence and the recurrence of private part diseases. The invention preferably prepares the private part care product into a paste preparation, is convenient to use, can be used for daily private part cleaning, and can be used by both men and women.
The raw materials used in the following examples of the present invention are all commercially available products, and the acrylic acid (ester) copolymer was purchased from Guangzhou Megay trade development Co., Ltd.
Example 1
The preparation method of the polygonum hydropiper extract, the oldenlandia diffusa extract, the angelica sinensis extract and the Chinese violet extract comprises the following steps: pulverizing dried herba Polygoni Hydropiperis, herba Hedyotidis Diffusae, radix Angelicae sinensis, and herba Violae, respectively weighing 100g of the above medicinal materials powder, adding 65% ethanol water solution 8 times the weight of the medicinal materials powder, soaking for 45min, refluxing at 70 deg.C for 2 times, each time for 3 hr, mixing extractive solutions, recovering ethanol, concentrating under reduced pressure to 1g (crude drug)/mL to obtain each medicinal material extract, and refrigerating at 4 deg.C for use.
The preparation method of the perilla extract, the isatis root extract, the prinsepia utilis royle extract and the coptis extract comprises the following steps: pulverizing dried Perillae herba, radix Isatidis, Prinsepia utilis Royle and Coptidis rhizoma, weighing 100g of the above medicinal materials respectively, adding distilled water 6 times the weight of the medicinal materials, soaking for 60min, decocting at 60 deg.C for 3 times, each for 1 hr, filtering, mixing filtrates, concentrating under reduced pressure to 1.03g (crude drug)/mL to obtain each medicinal material extract, and refrigerating at 4 deg.C for use.
Formula of the personal care product: 2 wt% of sodium chloride, 9 wt% of glycerol, 18 wt% of sodium lauroyl glutamate, 10 wt% of cocamidopropyl betaine, 2 wt% of ethylene glycol distearate, 2 wt% of lauric acid, 0.4 wt% of lactic acid, 2 wt% of acrylic acid (ester) copolymer, 1.25 wt% of cactus extract, 1.25 wt% of polygonum hydropiper extract, 1.75 wt% of perilla extract, 1.25 wt% of spreading hedyotis herb extract, 2 wt% of isatis root extract, 1.75 wt% of prinsepia utilis royle extract, 2 wt% of coptis chinensis extract, 2.5 wt% of angelica sinensis extract, 2 wt% of philippine violet herb extract, 0.2 wt% of ethylhexyl glycerol, 0.2 wt% of phenoxyethanol, 0.15 wt% of chlorphenesin and the balance of.
The preparation method comprises the following steps: 1) mixing 34.3 wt% of water, sodium lauroyl glutamate, sodium chloride and glycerol, heating to 80 deg.C, stirring, and keeping the temperature for 15min to obtain a first mixture; 2) adding cocamidopropyl betaine, ethylene glycol distearate, lauric acid and citric acid into the first mixture, uniformly stirring, and cooling to obtain a second mixture; 3) when the temperature is reduced to 60 ℃, adding the cactus extract, the polygonum hydropiper extract, the perilla extract, the spreading hedyotis herb extract, the isatis root extract, the prinsepia utilis royle extract, the coptis chinensis extract, the angelica sinensis extract and the Chinese violet extract into the second mixture, and uniformly stirring to obtain a mixed solution; 4) dissolving the acrylic acid (ester) copolymer into the rest water in advance, then adding the acrylic acid (ester) copolymer into the mixed solution obtained in the step 3), uniformly stirring, and cooling to obtain a third mixture; 5) when the temperature is reduced to 40 ℃, adding ethylhexyl glycerol, phenoxyethanol and chlorphenesin to the third mixture, and stirring uniformly to obtain the personal care product.
Example 2
The preparation method of the polygonum hydropiper extract, the oldenlandia diffusa extract, the angelica sinensis extract and the Chinese violet extract comprises the following steps: pulverizing dried herba Polygoni Hydropiperis, herba Hedyotidis Diffusae, radix Angelicae sinensis, and herba Violae, respectively weighing 100g of the above medicinal materials powder, adding 80% ethanol water solution 6 times the weight of the medicinal materials powder, soaking for 60min, refluxing at 75 deg.C for 2 times, each time for 2 hr, mixing extractive solutions, recovering ethanol, concentrating under reduced pressure to 1.05g (crude drug)/mL to obtain each medicinal material extract, and refrigerating at 4 deg.C for use.
The preparation method of the perilla extract, the isatis root extract, the prinsepia utilis royle extract and the coptis extract comprises the following steps: pulverizing dried Perillae herba, radix Isatidis, Prinsepia utilis Royle and Coptidis rhizoma, weighing 100g of the above medicinal materials respectively, adding distilled water 8 times the weight of the medicinal materials, soaking for 45min, decocting at 85 deg.C for 2 times, each for 2 hr, filtering, mixing filtrates, concentrating under reduced pressure to 1g (crude drug)/mL to obtain extracts, and refrigerating at 4 deg.C for use.
The formula of the private part care product is as follows: 1 wt% of sodium chloride, 12 wt% of glycerol, 19 wt% of sodium lauroyl glutamate, 16 wt% of cocoyl propyl betaine, 3 wt% of ethylene glycol distearate, 1.5 wt% of lauric acid, 0.8 wt% of citric acid, 0.5 wt% of acrylic acid (ester) copolymer, 0.5 wt% of cactus extract, 2 wt% of polygonum hydropiper extract, 1 wt% of perilla extract, 2 wt% of oldenlandia diffusa extract, 1 wt% of isatis root extract, 1 wt% of prinsepia utilis royle extract, 3 wt% of coptis chinensis extract, 1 wt% of angelica sinensis extract, 1 wt% of philippine violet herb extract, 0.3 wt% of ethylhexyl glycerol, 0.1 wt% of phenoxyethanol, 0.2 wt% of chlorphenesin and the balance of.
The preparation method of the private care product comprises the following steps: 1) mixing 32.1 wt% of water, sodium lauroyl glutamate, sodium chloride and glycerol, heating to 85 deg.C, stirring, and keeping the temperature for 10min to obtain a first mixture; 2) adding cocamidopropyl betaine, ethylene glycol distearate, lauric acid and citric acid into the first mixture, uniformly stirring, and cooling to obtain a second mixture; 3) when the temperature is reduced to 65 ℃, adding the cactus extract, the polygonum hydropiper extract, the perilla extract, the spreading hedyotis herb extract, the isatis root extract, the prinsepia utilis royle extract, the coptis chinensis extract, the angelica sinensis extract and the Chinese violet herb extract into the second mixture, and uniformly stirring to obtain a mixed solution; 4) dissolving the acrylic acid (ester) copolymer into the rest water in advance, then adding the acrylic acid (ester) copolymer into the mixed solution obtained in the step 3), uniformly stirring, and cooling to obtain a third mixture; 5) when the temperature is reduced to 40 ℃, adding ethylhexyl glycerol, phenoxyethanol and chlorphenesin to the third mixture, and stirring uniformly to obtain the personal care product.
Example 3
The preparation method of the polygonum hydropiper extract, the oldenlandia diffusa extract, the angelica sinensis extract and the Chinese violet extract comprises the following steps: pulverizing dried herba Polygoni Hydropiperis, herba Hedyotidis Diffusae, radix Angelicae sinensis, and herba Violae, respectively weighing 100g of the above medicinal materials powder, adding 50% ethanol water solution 10 times the weight of the medicinal materials powder, soaking for 30min, refluxing at 60 deg.C for 3 times, each time for 2 hr, mixing extractive solutions, recovering ethanol, concentrating under reduced pressure to 1.03g (crude drug)/mL to obtain each medicinal material extract, and refrigerating at 4 deg.C for use.
The preparation method of the perilla extract, the isatis root extract, the prinsepia utilis royle extract and the coptis extract comprises the following steps: pulverizing dried Perillae herba, radix Isatidis, Prinsepia utilis Royle and Coptidis rhizoma, weighing 100g of the above medicinal materials respectively, adding distilled water 10 times the weight of the medicinal materials, soaking for 30min, decocting at 75 deg.C for 3 times, each for 2 hr, filtering, mixing filtrates, concentrating under reduced pressure to 1.05g (crude drug)/mL to obtain each medicinal material extract, and refrigerating at 4 deg.C for use.
The formula of the private part care product is as follows: 3 wt% of sodium chloride, 6 wt% of glycerol, 8 wt% of sodium lauroyl glutamate, 12 wt% of cocoyl propyl betaine, 1 wt% of ethylene glycol distearate, 2.5 wt% of lauric acid, 0.6 wt% of lactic acid, 2.5 wt% of acrylic acid (ester) copolymer, 2 wt% of cactus extract, 0.5 wt% of polygonum hydropiper extract, 2.5 wt% of perilla extract, 0.5 wt% of oldenlandia diffusa extract, 3 wt% of isatis root extract, 2.5 wt% of prinsepia utilis royle extract, 1 wt% of coptis chinensis extract, 4 wt% of angelica sinensis extract, 3 wt% of philippine violet herb extract, 0.1 wt% of ethylhexyl glycerol, 0.3 wt% of phenoxyethanol, 0.1 wt% of chlorphenesin and the balance.
The preparation method of the private care product comprises the following steps: 1) mixing 39.4 wt% of water, sodium lauroyl glutamate, sodium chloride and glycerol, heating to 85 deg.C, stirring, and keeping the temperature for 10min to obtain a first mixture; 2) adding cocamidopropyl betaine, ethylene glycol distearate, lauric acid and citric acid into the first mixture, uniformly stirring, and cooling to obtain a second mixture; 3) when the temperature is reduced to 65 ℃, adding the cactus extract, the polygonum hydropiper extract, the perilla extract, the spreading hedyotis herb extract, the isatis root extract, the prinsepia utilis royle extract, the coptis chinensis extract, the angelica sinensis extract and the Chinese violet herb extract into the second mixture, and uniformly stirring to obtain a mixed solution; 4) dissolving the acrylic acid (ester) copolymer into the rest water in advance, then adding the acrylic acid (ester) copolymer into the mixed solution obtained in the step 3), uniformly stirring, and cooling to obtain a third mixture; 5) when the temperature is reduced to 40 ℃, adding ethylhexyl glycerol, phenoxyethanol and chlorphenesin to the third mixture, and stirring uniformly to obtain the personal care product.
Example 4
The formula and preparation method of the personal care product are the same as those in example 1, except that no oldenlandia diffusa extract, polygonum hydropiper extract, perilla extract, isatis root extract, prinsepia utilis royle extract and philippine violet herb extract are used, and the amount of cactus extract is 4.25 wt%, the amount of coptis extract is 5.5 wt%, and the amount of angelica extract is 6 wt%.
Example 5
The formula and preparation method of the personal care product are the same as example 1, except that the radix isatidis extract, the prinsepia utilis royle extract and the viola yedoensis extract are not used, and the content of the cactus extract is 2.25 wt%, the content of the coptis chinensis extract is 3 wt%, the content of the angelica sinensis extract is 3.5 wt%, the content of the oldenlandia diffusa extract is 2.25 wt%, the content of the polygonum hydropiper extract is 2.25 wt%, and the content of the perilla extract is 2.5 wt%.
Comparative example 1
The formula and preparation method of the personal care product were the same as in example 4 except that the cactus extract and the coptis root extract were not used and the angelica extract was used in an amount of 15.75 wt%.
Comparative example 2
The formula and preparation method of the personal care product were the same as in example 4 except that the angelica extract and the coptis extract were not used and the cactus extract was used in an amount of 15.75 wt%.
Comparative example 3
The formula and preparation method of the personal care product were the same as in example 4 except that the angelica extract and the cactus extract were not used and the coptis extract was used in an amount of 15.75 wt%.
Example 6 in vitro antibacterial Performance test
Clinical isolated strains of staphylococcus aureus, escherichia coli and candida albicans are respectively cultured in a culture medium, the private care products prepared in examples 1-5 and comparative examples 1-3 are used as test objects, operation is carried out according to national standard GB15979-2002, the detection results are shown in table 1, and table 1 is the in-vitro antibacterial performance test result of the private care product prepared in the embodiment of the invention.
TABLE 1 in vitro antibacterial Performance test results for Care products prepared according to the examples of the invention
As can be seen from Table 1, the product for caring private parts provided by the invention has significant antibacterial activity against Staphylococcus aureus, Escherichia coli and Candida albicans, which are common pathogenic bacteria in private parts, and can maintain the balance of the flora in private parts.
Example 7 irritation test on vaginal mucosa
12 common-grade female New Zealand rabbits with the weight of 2-2.5 kg are randomly divided into 4 groups, the experimental group is the private care product prepared in the embodiment 1-3 of the invention, the control group is sterilized normal saline, 3 animals are respectively used, and the vaginal orifice of the animal is checked for secretion, congestion, edema and other conditions before the test. Fixing the animal on the back, exposing the vaginal opening, wetting the catheter with normal saline, gently inserting the catheter into the vagina (4-5 cm), slowly injecting 2mL of test object with an injector, and withdrawing the catheter to finish the contamination. After 24 hours, the animals were sacrificed by air embolism, the vagina was completely cut off and longitudinally incised, and the presence of congestion, edema and the like was visually observed. The detection result is as follows: the vaginal mucosa of each group of experimental animals has no congestion, edema and erosion, and the stimulation index of the vaginal mucosa is less than 1, so that the private care product provided by the invention has no stimulation to the vaginal mucosa.
Example 8 clinical efficacy testing
360 women are selected and divided into 4 groups at the age of 25-55, wherein each group comprises 30 people suffering from bacterial vaginitis, 30 people suffering from trichomonas vaginitis and 30 people suffering from comprehensive vaginitis, and the 4 groups respectively use the private part care products prepared in the embodiments 1-3 of the invention.
TABLE 2 clinical results of testing the efficacy of the personal care products prepared in accordance with the present invention
As can be seen from Table 2, the effect of the product for caring private parts provided by the invention is remarkable and is obviously higher than that of a control group, and the product can effectively prevent the occurrence and recurrence of private diseases.
As can be seen from the above examples, the present invention provides an antimicrobial composition comprising: cactus extract, coptis root extract and angelica extract. The invention provides a personal care product comprising the antimicrobial composition. The effective components of the antibacterial composition provided by the invention are traditional Chinese medicine extracts, and the antibacterial composition is mild and non-irritant, and the cactus extract, the coptis extract and the angelica extract are mutually matched to have a synergistic effect, so that the antibacterial composition has a good bactericidal effect. The antibacterial composition provided by the invention is used for preparing the private part care product, and the antibacterial composition does not contain a chemical bactericide and has a good bactericidal effect, so that the prepared private part care product is safe, mild and non-irritant, can effectively clean private parts, balance acid-base and flora environments, inhibit the growth and reproduction of pathogenic bacteria in the private parts, and simultaneously has the effects of sterilizing, diminishing inflammation, relieving itching and removing peculiar smell.
Claims (4)
1. A intimate care product comprising:
cactus extract, coptis chinensis extract, angelica sinensis extract, oldenlandia diffusa extract, polygonum hydropiper extract, perilla extract, isatis root extract, prinsepia utilis royle extract and Chinese violet extract;
the mass ratio of the cactus extract to the coptis chinensis extract to the angelica sinensis extract to the oldenlandia diffusa extract to the polygonum hydropiper extract to the perilla extract to the isatis root extract to the prinsepia utilis royle extract to the philippine violet herb extract is (0.5-2): (1-3): (1-4): (0.5-2) and (0.5-2): (1-2.5): (1-3) in (1-2.5): (1-3);
the preparation method of the polygonum hydropiper extract, the oldenlandia diffusa extract, the angelica sinensis extract and the Chinese violet extract comprises the following steps:
crushing dried polygonum hydropiper, oldenlandia diffusa, angelica sinensis and Chinese violet, respectively weighing the medicinal material powder, adding 50-80% ethanol water solution with the mass concentration 6-10 times of the mass of the medicinal material powder, soaking for 30-60 min, refluxing for 2-3 times at 60-75 ℃, each time for 2-3 h, combining extracting solutions, recovering ethanol, and concentrating under reduced pressure to 1-1.05 g/mL to prepare each medicinal material extract;
the preparation method of the perilla extract, the isatis root extract, the prinsepia utilis royle extract and the coptis extract comprises the following steps:
crushing dried perilla, isatis root, prinsepia utilis royle and coptis, weighing the medicinal material powder, adding distilled water with the mass 6-10 times of that of the medicinal material powder, soaking for 30-60 min, decocting for 2-3 times at 60-85 ℃ for 1-2 h each time, filtering, combining filtrates, and concentrating under reduced pressure to 1-1.05 g/mL to prepare each medicinal material extract.
2. The intimate care product of claim 1, further comprising:
thickening agent, solvent, surfactant, foam stabilizer, preservative, stabilizer and/or acidity regulator.
3. The personal care product of claim 2, wherein said surfactant is an amino acid surfactant.
4. The intimate care product of claim 2, further comprising: pearlescent flakes and/or preservative enhancers.
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| CN107260637A (en) * | 2017-07-24 | 2017-10-20 | 北京正德个人护理用品科技有限公司 | Secret nurses shower cream |
| CN109666545B (en) * | 2018-12-28 | 2020-10-02 | 中山市天图精细化工有限公司 | Efficient toilet cleaning foam aerosol and preparation method thereof |
| CN111658600B (en) * | 2020-07-31 | 2022-09-16 | 山东元核生物工程有限公司 | Biological nursing lotion and preparation method thereof |
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Denomination of invention: An antibacterial composition and a private care product Effective date of registration: 20201125 Granted publication date: 20200609 Pledgee: Guangzhou Development Zone sub branch of Huaxia Bank Co.,Ltd. Pledgor: GUANGZHOU RUI SEN BIOTECHNOLOGY Co.,Ltd. Registration number: Y2020440000368 |
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