CN109010529A - A kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing - Google Patents

A kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing Download PDF

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Publication number
CN109010529A
CN109010529A CN201810854734.4A CN201810854734A CN109010529A CN 109010529 A CN109010529 A CN 109010529A CN 201810854734 A CN201810854734 A CN 201810854734A CN 109010529 A CN109010529 A CN 109010529A
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CN
China
Prior art keywords
vagina
chinese medicine
traditional chinese
sodium hyaluronate
chitosan oligosaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810854734.4A
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Chinese (zh)
Inventor
王正军
张琳
刘燕玲
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Suzhou Meishi Biological Technology Co Ltd
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Suzhou Meishi Biological Technology Co Ltd
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Priority to CN201810854734.4A priority Critical patent/CN109010529A/en
Publication of CN109010529A publication Critical patent/CN109010529A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

The present invention provides a kind of Traditional Chinese medicine bacteriostatic gelling agents for vagina nursing, are made of the raw material of following weight ratio: frutus cnidii, kuh-seng, olibanum, honeysuckle, safflower, Radix Angelicae Sinensis, biological peptide, Cranberry, chitosan oligosaccharide, sodium hyaluronate, borneol, carbomer, remaining be purified water；Product of the invention enters after vagina, affected part can be diffused to rapidly, destroy the living environment of harmful bacteria, adjust the colony balance and acid-base balance of intravaginal, effective component of chinese medicine is combined with the composition of the macromolecular structures such as biological peptide, chitosan oligosaccharide, sodium hyaluronate, and vaginal mucosa is goed deep into easily infiltration, repairs disrupted tissue and then gradually clears up bacterium, the fungi for being attached to intravaginal, the autoimmunity of vagina is set gradually to be restored, while moist vagina that can also be fabulous.

Description

A kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing.
Background technique
The vagina of female reproductive system, due to various reasons, vagina can be by pathogenic infections, or because of the colony balance of vagina Cause vaginal environment to change with acid-base balance problem, leads to colporrhagia or various gynaecological diseases, in terms of Chinese medicine angle, fungoid The etiology and pathogenesis of vaginopathy is mostly because of insufficiency of the spleen resulting in production of dampness, damp flowing downward to lower-JIAO；The etiology and pathogenesis of trichomonas vaginitis mainly because of stagnated heat of liver channel, Caused by intrinsic heat adult；The etiology and pathogenesis main mechanism of senile vahinitis is the deficiency of liver-yin and kidney-yin, and damp invasion of lower energizer is mainly thought in doctor trained in Western medicine Caused by virus or germ infection, vaginitis brings long-term health, life to perplex to women, or even seriously affects psychological strong Health.
Summary of the invention
According to above-mentioned elaboration, the purpose of the present invention is to provide a kind of Chinese medicine composition gels, for inhibiting vaginal mucosa Infection, the effect with activating microcirculation and removing stasis medicinal, antibacterial anti-inflammatory.
Technical solution provided by the invention: a kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing, is by following heavy The raw material of amount ratio is made:
Frutus cnidii 1%-10%, kuh-seng 1%-15%, olibanum 1%-10%, honeysuckle 1%-10%, safflower 1%, when Return 1%-5%, biological peptide 1%-2%, Cranberry 0.1%-0.2%, chitosan oligosaccharide 0.1%-0.2%, sodium hyaluronate 0.1%- 0.2%, borneol 1%-2%, carbomer 1%-2%, remaining be purified water；
In above-mentioned technical proposal, frutus cnidii 10%, kuh-seng 15%, olibanum 10%, honeysuckle 10%, safflower 1%, Radix Angelicae Sinensis 5%, biological peptide 1%, Cranberry 0.1%, chitosan oligosaccharide 0.1%, sodium hyaluronate 0.1%, borneol 2%, carbomer 1%, remaining be pure Change water.
A kind of preparation method of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing provided by the invention is: will be described heavy Measure part raw material: biological peptide, Cranberry, chitosan oligosaccharide, the frutus cnidii of sodium hyaluronate and parts by weight, kuh-seng, olibanum, honeysuckle, safflower, Radix Angelicae Sinensis, Borneolum Syntheticum extract, mix with carbomer, and purified water is added and mixes gel.
The extraction of Chinese medicine uses aqueous solvent extracting mode, the effective component of extraction.
For the present invention based on pathogenesis and treatment principle to gynecological disease, compatibility is reasonable, scientific, tests through a large amount of clinics Card, without any toxicity and side effects, product of the invention enters after vagina, can diffuse to affected part rapidly, destroys the existence ring of harmful bacteria Border adjusts the colony balance and acid-base balance of intravaginal, and it is big that effective component of chinese medicine is combined with biological peptide, chitosan oligosaccharide, sodium hyaluronate etc. The composition of molecular structure, easily infiltration go deep into vaginal mucosa, and repairing disrupted tissue, then gradually cleaning is attached to the thin of intravaginal Bacterium, fungi make the autoimmunity of vagina gradually be restored, while moist vagina that can also be fabulous.
Specific embodiment
Technical solution of the present invention is clearly and completely described below, it is clear that described embodiment is only this Invention a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art exist Every other embodiment obtained under the premise of creative work is not made, shall fall within the protection scope of the present invention.
Compatibility of drugs of the invention is reasonable, and component effect is:
Frutus cnidii, warm-natured, bitter return kidney channel, and the present invention utilizes antibacterial, antiinflammation.
Kuh-seng, bitter is cold in nature, return heart, liver, bladder meridian, has heat-clearing, and the effect of eliminating dampness can control trichomonas vaginitis.
Olibanum, acrid flavour, hardship are warm-natured.Return heart, liver, the spleen channel have promoting blood circulation analgesic therapy, the function of detumescence and promoting granulation.
Honeysuckle, cold in nature, sweet in flavor, channel tropism lung, stomach meridian, the present invention using honeysuckle resisting pathogenic microbes, it is anti-inflammatory, antipyretic, Anti-allergic effects.
Safflower, it is sweet in flavor mild-natured, activating microcirculation and removing stasis medicinal is used in the present invention.
Radix Angelicae Sinensis, it is sweet in flavor, pungent, bitter, it is warm-natured, enter liver, the heart, the spleen channel, it can be with blood-nourishing and blood, tonifying blood and regulating menstruation, promoting blood circulation and stopping pain.
Biological peptide adjusts the physiological function of internal cell, activates related enzyme system in vivo, promotes the permeability of intermediate supersession film The effect of.
The benefits of sodium hyaluronate plays lubrication moisturizing and nourishing, restores epidermis smooth resilient.
Cranberry, cool, sweet, sour, return heart, kidney channel can prevent urethral infection.
Borneol, acrid flavour, hardship, cold nature, return heart, spleen, lung channel have the effect of heat-clearing dissipates poison.
Chitosan oligosaccharide, good water solubility, function is big, is easily absorbed by the body, bioactivity height.
Carbomer is the effect of thickening.
According to above-mentioned component and compatibility principle analysis, the present invention, following embodiment is disclosed.
Embodiment:
Take: a kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing, is to be made from the following raw materials in parts by weight:
The kuh-seng that common cnidium fruit P.E 100g that frutus cnidii effective content is 10%, matrine effective content are 98% extracts The honeysuckle that olibanum seed extract 100g that object 150g, olibanum effective content are 10%, honeysuckle effective content are 10% is extracted The angelica extract that safranine flower extract 10g that object 100g, safflower effective content are 10%, Radix Angelicae Sinensis effective content are 10% 5g, biological peptide 10g, the Cranberry extract 1g that Cranberry effective content is 10%, chitosan oligosaccharide 1g, borneol 20g, carbomer 10g, Add purified water to 1000g, stirs evenly gelled, the last weight of mixture is 1000g.
In use, Chinese medicine composition gel is injected intravaginal by patient.
To show fungistatic effect of the invention, the embodiment of the present invention does bacteriostatic test:
One, equipment
1, test strain: Escherichia coli (8099) are cultivated 9 generations, Candida albicans (ATCC10231), culture 9 generations, golden yellow Color staphylococcus (ATCC6538) cultivated for 9 generations, is provided by Chinese Culture Collection Center.
2, sabouraud's agar is provided by Beijing road and bridge technology Co., Ltd.
3/0.03mol/L phosphate buffer solution (PBS)
4, carrier: filter paper (2.0cm × 3.0cm), sterile measuring pipette, sterilized petri dishes, sterile test tube, constant incubator Deng
Two, sample is the present embodiment 5g, is put into sterile mortar grinding, crushes, mixes, is put into sterilized petri dishes and is directly pressed down Bacterium test.
Three, method is according to GB15979-200 " Disposable Sanitary Accessory sanitary standard " appendix C 4, " disinfection technology rule Model " 2002 editions 2.1.8 test.
Bacteriostatic test is carrier test, and 20 DEG C ± 1 DEG C of test temperature, test is repeated 5 times.
Four, result
Under conditions of 20 DEG C ± 2 DEG C of test temperature, embodiment is to Escherichia coli, Candida albicans, Staphylococcus aureus Bacterium inhibitory effect.
The embodiment of the present invention is shown in Table 1 to the inhibitory effect inspection of staphylococcus aureus；
The inhibitory effect of 1 staphylococcus aureus of table
The embodiment of the present invention is shown in Table 2 for the inhibitory effect inspection of Candida albicans.
The inhibitory effect of 2 Candida albicans of table
The embodiment of the present invention is shown in Table 3 to the inhibitory effect inspection of Escherichia coli；
The inhibitory effect of 3 Escherichia coli of table
The conclusion tested above, for embodiment to Escherichia coli, Candida albicans, staphylococcus aureus inhibiting rate are reachable 90% or more.
To show clinical application effect of the invention, the present invention is proved through clinical and experimental study: to the composition of embodiment Crowd through age groups and different gynaecological diseases carries out test effect, and through testing, this product is for bacterial vaginitis, trichomonad Property the vaginal diseases such as vaginitis, monilial vaginitis, purulent vaginitis, colpitis simplex there is good effect, such as Patient there are leucorrhea increasing or has vulva to have itch, scorching hot before use, and the symptoms such as vaginal relaxation must after using 7-15 days To biggish improvement, when use after cleaning vulva, 5 grams of this product is taken, gel is slowly injected to vagina discomfort position.Daily 1-2 It is secondary, 5 grams every time.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain Lid is within protection scope of the present invention.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (2)

1. a kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing, it is characterised in that: be by the raw material system of following weight ratio At: frutus cnidii 1%-10%, kuh-seng 1%-15%, olibanum 1%-10%, honeysuckle 1%-10%, safflower 1%, Radix Angelicae Sinensis 1%- 5%, biological peptide 1%-2%, Cranberry 0.1%-0.2%, chitosan oligosaccharide 0.1%-0.2%, sodium hyaluronate 0.1%-0.2%, borneol 1%-2%, carbomer 1%-2%, remaining be purified water；
By the raw material: biological peptide, Cranberry, chitosan oligosaccharide, sodium hyaluronate and parts by weight frutus cnidii, kuh-seng, olibanum, gold Honeysuckle flower, safflower, Radix Angelicae Sinensis, Borneolum Syntheticum extract, mix with carbomer, and purified water is added and mixes gel.
2. it is according to claim 1 it is a kind of for vagina nursing Traditional Chinese medicine bacteriostatic gelling agent, it is characterised in that: be by The raw material of following weight ratio is made: frutus cnidii 10%, kuh-seng 15%, olibanum 10%, honeysuckle 10%, safflower 1%, Radix Angelicae Sinensis 5%, biological peptide 1%, Cranberry 0.1%, chitosan oligosaccharide 0.1%, sodium hyaluronate 0.1%, borneol 2%, carbomer 1%, remaining be pure Change water.
CN201810854734.4A 2018-07-30 2018-07-30 A kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing Pending CN109010529A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810854734.4A CN109010529A (en) 2018-07-30 2018-07-30 A kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810854734.4A CN109010529A (en) 2018-07-30 2018-07-30 A kind of Traditional Chinese medicine bacteriostatic gelling agent for vagina nursing

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110464832A (en) * 2019-09-20 2019-11-19 北京希也技术发展有限公司 A kind of polypeptide nursing bacteriostatic gel
CN112807419A (en) * 2020-09-28 2021-05-18 臻锦生物科技(武汉)有限公司 Pharmaceutical composition, preparation method thereof, external medicine and application
CN113244287A (en) * 2021-05-10 2021-08-13 广州天恩药业科技有限公司 Traditional Chinese medicine preparation formula for treating female vaginitis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110464832A (en) * 2019-09-20 2019-11-19 北京希也技术发展有限公司 A kind of polypeptide nursing bacteriostatic gel
CN112807419A (en) * 2020-09-28 2021-05-18 臻锦生物科技(武汉)有限公司 Pharmaceutical composition, preparation method thereof, external medicine and application
CN113244287A (en) * 2021-05-10 2021-08-13 广州天恩药业科技有限公司 Traditional Chinese medicine preparation formula for treating female vaginitis

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