CN110339337A - One kind taking off black, the gel combination of nourishing for vagina relaxation - Google Patents
One kind taking off black, the gel combination of nourishing for vagina relaxation Download PDFInfo
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- CN110339337A CN110339337A CN201810283464.6A CN201810283464A CN110339337A CN 110339337 A CN110339337 A CN 110339337A CN 201810283464 A CN201810283464 A CN 201810283464A CN 110339337 A CN110339337 A CN 110339337A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The present invention provides one kind for vagina relaxation, takes off black, the gel combination of nourishing is made of the raw material of following weight ratio: propolis, frutus cnidii, kuh-seng, olibanum, honeysuckle, safflower, Radix Angelicae Sinensis, chitosan, sodium hyaluronate, biological peptide, bioprotein;Product of the invention enters after vagina, uncomfortable place can be diffused to rapidly, go deep into skin texture, promote cell metabolism by the drug effect that pharmaceutical composition plays, to enhance cell absorption of drugs ability, improves intravaginal epidermal cell living environment, promote the secretion of hyaluronic acid, collagen, it complements each other with effective ingredient, the intravaginal elasticity of muscle is further promoted to enhance, achieve the purpose that improve relaxation, nourish lubrication;By the combination of biological peptide, bioprotein and effective component of chinese medicine, enhance drug molecule penetrability, go deep into capillary, alleviates melanin deposition, to achieve the purpose that take off black.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to one kind takes off black, the gel group of nourishing for vagina relaxation
Close object.
Background technique
Vaginal relaxation is a kind of physiological signs that women gradually generates with age, female as female age increases
Sex hormone secretion, which is reduced, will lead to the decline of vagina contraction power;Pelvic muscle group restores bad after pregnancy spontaneous labor, and tension is impaired
And lead to the major reason of vaginal relaxation, in addition there are because of vaginal relaxation caused by gynecological disease obstinate.Private parts blackening
It is after sexual stimulus, local capillary stretching attenuates, and blood oxygen exchange has little time the hemochrome returned deposition, and aging is in addition black
Gradually centrality deposits pigment, and labia color is more and more obscure.Vaginal relaxation is always to perplex the most tired gynaecology of female friend to ask
One of topic, vaginal relaxation inevitably result in the self-cleaning ability decline of vagina, and vaginal relaxation will lead to vagina peculiar smell, leucorrhea increasing,
A series of problems, such as to further bring gynaecological imflammation, the numerous female friends' physical and mental health of this strong influence and normal
Family life.Mainly pass through operation and drug therapy for the treatment of vaginal relaxation at present, operative treatment risk is big, cure rate
Lowly, the risk that body is accompanied by recurrence is not only injured;Drug therapy is mainly vaginal injection, and the methods of oral drugs pass through
Drug absorption, which diffuses to, reaches therapeutic purposes at skin texture, but to there is absorptivity lower for existing drug, and side effect is big and nothing
The problem of method is eradicated.
Summary of the invention
According to above-mentioned elaboration, the present invention based on the pathogenesis and treatment principle to vaginal relaxation, compatibility rationally, section
Learn, it is without any toxicity and side effects, and it is an object of the present invention to provide a kind of for vagina relaxation through a large amount of clinical verifications, take off it is black, nourishing it is solidifying
Glue composition.
Technical solution provided by the invention: one kind for vagina relaxation, take off black, the gel combination of nourishing, be by
The raw material of following weight ratio is made:
Propolis 1%~3%, frutus cnidii 8%~15%, kuh-seng 1%~3%, olibanum 1%~3%, honeysuckle 1%~
3%, safflower 4%~6%, Radix Angelicae Sinensis 1%~6%, chitosan 1%~3%, sodium hyaluronate 2%~4%, biological peptide 1%~3%,
Bioprotein 1%~3%, remaining be purified water.
In above-mentioned technical proposal, propolis 1%, frutus cnidii 8%, kuh-seng 1%, olibanum 1%, honeysuckle 1%, safflower 4%,
Radix Angelicae Sinensis 1%, chitosan 1%, sodium hyaluronate 2%, biological peptide 1%, bioprotein 1%, remaining be purified water.
In above-mentioned technical proposal, propolis 2%, frutus cnidii 10%, kuh-seng 2%, olibanum 2%, honeysuckle 1.5%, safflower
4.5%, Radix Angelicae Sinensis 3%, chitosan 1.5%, sodium hyaluronate 3%, biological peptide 1.5%, bioprotein 2%, remaining be purified water.
In above-mentioned technical proposal, propolis 2.5%, frutus cnidii 12%, kuh-seng 3%, olibanum 3%, honeysuckle 3%, safflower
5%, Radix Angelicae Sinensis 5%, chitosan 2%, sodium hyaluronate 3%, biological peptide 2%, bioprotein 2%, remaining be purified water.
Provided by the invention kind, for vagina relaxation, takes off black, the preparation method of the gel combination of nourishing is: by institute
State raw material: chitosan, sodium hyaluronate, biological peptide, bioprotein and parts by weight propolis, frutus cnidii, kuh-seng, olibanum, gold
Honeysuckle flower, safflower, Radix Angelicae Sinensis mixing, are added purified water and mix gel.
The extraction of Chinese medicine uses aqueous solvent extracting mode, the effective component of extraction.
For the present invention based on pathogenesis and treatment principle to vaginal relaxation, compatibility is reasonable, scientific, tests through a large amount of clinics
Card, without any toxicity and side effects, product of the invention enters after vagina, can diffuse to uncomfortable place rapidly, go deep into skin texture, pass through drug
The drug effect that combination plays promotes cell metabolism, to enhance cell absorption of drugs ability, it is thin to improve vagina endepidermis
Born of the same parents' living environment promotes the secretion of hyaluronic acid, collagen, complements each other with effective ingredient, further promote vagina
Interior elasticity of muscle enhancing achievees the purpose that improve relaxation, nourishes lubrication;Pass through biological peptide, bioprotein and effective component of chinese medicine
Combination, enhance drug molecule penetrability, go deep into capillary, alleviate melanin deposition, to achieve the purpose that take off black.
Specific embodiment
Technical solution of the present invention is clearly and completely described below, it is clear that described embodiment is only this
Invention a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art exist
Every other embodiment obtained under the premise of creative work is not made, shall fall within the protection scope of the present invention.
Compatibility of drugs of the invention is reasonable, and component effect is:
Propolis has the effect of moisturizing myogenic, anti-inflammatory analgetic.
Frutus cnidii, warm-natured, bitter return kidney channel, and the present invention utilizes antibacterial, antimycotic, anti-inflammatory effect.
Kuh-seng, bitter is cold in nature, return heart, liver, stomach, large intestine, bladder meridian, has heat-clearing, eliminating dampness, and the effect of desinsection can control drop
Worm property vaginitis.
Olibanum, acrid flavour, hardship are warm-natured.Return heart, liver, the spleen channel, the present invention utilize olibanum promoting blood circulation analgesic therapy, the function of detumescence and promoting granulation.
Honeysuckle, it is cold in nature, it is sweet in flavor, enter lung, the heart, stomach meridian, the present invention function clearing heat and detoxicating, anti-inflammatory using honeysuckle.
Radix Angelicae Sinensis, property is sweet, acrid flavour, temperature, returns liver, the heart, the spleen channel, effect of the Radix Angelicae Sinensis in antibacterial anti-inflammatory of the present invention.
The effect of safflower, function of promoting blood circulation to disperse blood clots is strong, and the present invention utilizes safflower activating microcirculation and removing stasis medicinal, swelling and pain relieving.
The benefits of sodium hyaluronate plays lubrication moisturizing and nourishing, restores epidermis smooth resilient.
Biological peptide adjusts the physiological function of internal cell, activates related enzyme system in vivo, promotes the permeability of intermediate supersession film
The effect of.
Bioprotein, enhancing is immune, hormone control, antibacterial, it is antiviral the effect of.
Chitosan is the effect of thickening.
According to above-mentioned component and compatibility principle analysis, the present invention, following embodiment is disclosed.
Embodiment:
Take: kind takes off black, the gel combination of nourishing is to be made from the following raw materials in parts by weight for vagina relaxation:
Common cnidium fruit P.E 80g that propolis 10g that propolis effective content is 10%, frutus cnidii effective content are 10%, hardship
Join the shrubby sophora extract 10g that alkali effective content is 98%, the olibanum seed extract 10g that olibanum effective content is 10%, honeysuckle
Safranine flower extract 40g that Honegsukle flower P.E 10g that effective content is 10%, safflower effective content are 10%, Radix Angelicae Sinensis have
Imitate the angelica extract 10g that content is 10%, chitosan 10g, sodium hyaluronate 20g, biological peptide 10g, bioprotein 10g plus purifying
Water stirs evenly gelled, the last weight of mixture is 1000g to 1000g.
In use, Chinese medicine composition gel is injected intravaginal by patient.
To show that improvement relaxing effect of the invention, the embodiment of the present invention do improvement relaxation test:
One, material and method
Experimental animal provides the big ear various schools of thinkers rabbit 8 of Japan (produce) by Xi'an Jiaotong University Medical College's Experimental Animal Center,
Female, 2.0-2.5kg of weight, primary animal, credit number: SCXK (Shan) 2014-003, the Xi'an traffic of feed padding source
University Medical College Experimental Animal Center provides.
Animal room environmental: 23-26 DEG C of temperature, relative humidity: 40%-50%.
Two, vaginal relaxation test method
1,2002 editions 2.1.8 of test basis " disinfection technology standard " test.
2, tested material dosage: 1.5g/ is only.
4, observation index: started to observe the variation of rabbit vagina volume using the 7th day after drug.
3, test method: the big ear various schools of thinkers rabbit of 8 estrus Japan (produce) label 1-8, supine is fixed when test,
Plastic catheter with sacculus is inserted by anesthesia by introitus, is slowly injected into physiological saline from conduit until air is arranged in sacculus
Out and it to be close to vaginal walls, records balloon volume (ml) at this time, this is the vagina normal volume before medication, after drug 7 days,
According to above-mentioned measurement method, intravaginal balloon volume is measured, vagina volume changes before and after measuring medication with this.
Three, test result
Influence of 1 gel of table to rabbit (produce) vagina
As shown in Table 1, obviously become smaller to drug of the present invention 7 days later vagina volumes of rabbit vagina, shrinking percentage is steady
It is scheduled between 30%~40%, illustrates that drug of the present invention has apparent effect to vaginal relaxation.
To show clinical application effect of the invention, the present invention is proved through clinical and experimental study: to the composition of embodiment,
Test effect is carried out through the crowd of age groups and different degrees of vaginal relaxation, through testing, is obtained after using 5-7 days
Biggish improvement.
This product when in use, after need to cleaning vulva, takes this product one, first removes the front cover of gel boost motor, and by institute
It takes front cover insertion boost motor rear end to use as push rod, slowly injects gel after lying low to vagina discomfort position, once a day,
One every time.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (4)
1. one kind takes off black, the gel combination of nourishing, it is characterised in that: be by following weight ratio for vagina relaxation
Raw material is made: propolis 1%~3%, frutus cnidii 8%~15%, kuh-seng 1%~3%, olibanum 1%~3%, honeysuckle 1%~
3%, safflower 4%~6%, Radix Angelicae Sinensis 1%~6%, chitosan 1%~3%, sodium hyaluronate 2%~4%, biological peptide 1%~3%,
Bioprotein 1%~3%, remaining be purified water.
By the raw material: chitosan, sodium hyaluronate, biological peptide, the propolis of bioprotein and parts by weight, frutus cnidii, kuh-seng,
Olibanum, honeysuckle, safflower, Radix Angelicae Sinensis mixing, are added purified water and mix gel.
2. according to claim 1 a kind of for vagina relaxation, take off black, the gel combination of nourishing, feature exists
In: propolis 1%, frutus cnidii 8%, kuh-seng 1%, olibanum 1%, honeysuckle 1%, safflower 4%, Radix Angelicae Sinensis 1%, chitosan 1%, glass
Uric acid 2%, biological peptide 1%, bioprotein 1%, remaining be purified water.
3. according to claim 1 a kind of for vagina relaxation, take off black, the gel combination of nourishing, feature exists
In: propolis 2%, frutus cnidii 10%, kuh-seng 2%, olibanum 2%, honeysuckle 1.5%, safflower 4.5%, Radix Angelicae Sinensis 3%, chitosan
1.5%, sodium hyaluronate 3%, biological peptide 1.5%, bioprotein 2%, remaining be purified water.
4. according to claim 1 a kind of for vagina relaxation, take off black, the gel combination of nourishing, feature exists
In: propolis 2.5%, frutus cnidii 12%, kuh-seng 3%, olibanum 3%, honeysuckle 3%, safflower 5%, Radix Angelicae Sinensis 5%, chitosan
2%, sodium hyaluronate 3%, biological peptide 2%, bioprotein 2%, remaining be purified water.
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CN201810283464.6A CN110339337A (en) | 2018-04-02 | 2018-04-02 | One kind taking off black, the gel combination of nourishing for vagina relaxation |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111000932A (en) * | 2020-01-02 | 2020-04-14 | 刘学林 | Traditional Chinese medicine for improving elasticity of vaginal mucosa |
CN111588783A (en) * | 2020-07-01 | 2020-08-28 | 北京心军生物科技股份有限公司 | Traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation and preparation method thereof |
CN111759969A (en) * | 2020-07-17 | 2020-10-13 | 贵州松桃信仁苗药有限公司 | Traditional Chinese medicine composition for treating vaginal relaxation |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111000932A (en) * | 2020-01-02 | 2020-04-14 | 刘学林 | Traditional Chinese medicine for improving elasticity of vaginal mucosa |
CN111588783A (en) * | 2020-07-01 | 2020-08-28 | 北京心军生物科技股份有限公司 | Traditional Chinese medicine combined antibacterial paste for treating gynecological inflammation and preparation method thereof |
CN111759969A (en) * | 2020-07-17 | 2020-10-13 | 贵州松桃信仁苗药有限公司 | Traditional Chinese medicine composition for treating vaginal relaxation |
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