CN107375012A - A kind of skin barrier remediation composition and preparation - Google Patents
A kind of skin barrier remediation composition and preparation Download PDFInfo
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- CN107375012A CN107375012A CN201710685213.6A CN201710685213A CN107375012A CN 107375012 A CN107375012 A CN 107375012A CN 201710685213 A CN201710685213 A CN 201710685213A CN 107375012 A CN107375012 A CN 107375012A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a kind of skin barrier remediation composition and agent is prepared, the composition is made up of following raw materials by weight percentage：Trehalose 0.05% 10%, Sodium Polyacrylate 0.1% 10%, surplus is glycerine.Experiment proves, formulation made of the skin barrier remediation composition of the present invention passes through to skin moisture-keeping, supplement oil content, effectively remissive treatment it can change redness after the beauty means such as skin caused by skin, heat pain via laser beautifying, tartaric acid, take off the symptoms such as skin, itch, assimilation effect is good, can also improve sensitive skin.Preparation method is simple, with short production cycle, and prescription is simplified, and cost is low.
Description
Technical field
The invention belongs to biomedicine technical field, is specifically related to a kind of skin barrier remediation composition and containing this
The preparation of composition.
Background technology
Two during the last ten years, and with deepening continuously for China's reform and opening-up, medical shaping and beauty industry is a dark horse, and development is fast
Speed, market is vigorous not to wane.21 century beauty is already required into the life of young women.2014, beauty mechanism of China
The overall market capacity has reached 553,000,000,000 yuan, wherein medical shaping and beauty market accounts for 3.8% share, i.e. medical shaping in 2014
Beauty industry whole nation total quantity consumed breaks through 21,000,000,000 yuan.Recent years, Chinese people are more and more stronger to beautiful and fashion pursuit
Strong, China's beauty industry will also persistently keep rapid growth situation.
The cardinal principle of laser beautifying employ it is beneficial to human body, through ability compared with it is strong, tissue absorptivity is high
Light-wave band, the stimulation using weak laser to biological tissue, facial meridian point is effectively stimulated, accelerates blood circulation,
Improve the supply condition of skin, increase skin tissue's nutrition, promote the anabolism and tissue repair of human body, so as to improve face
The colour of skin is dark and gloomy, pigmentation, cutis laxa, wrinkle, pouch are sagging, livid ring around eye, the thick, pachylosis of pore etc., makes facial skin
The ruddy gloss of skin, elasticity strengthen, the aging of delaying skin, play the effect of skin maintenance.But it can go out after laser beautifying sometimes
Existing skin barrier damaged phenomenon, and then there are the symptoms such as red, swollen, hot, pain, annoying these people to like to be beautiful.
The content of the invention
The purpose of the present invention is overcome the deficiencies in the prior art, there is provided a kind of skin barrier remediation composition.
Second object of the present invention is to provide a kind of preparation of remediation composition containing skin barrier.
Technical scheme is summarized as follows：
A kind of skin barrier remediation composition, is made up of following raw materials by weight percentage：Trehalose 0.05%-10%,
Sodium Polyacrylate 0.1%-10%, surplus are glycerine.
Preferably, trehalose 0.5%-1%, Sodium Polyacrylate 0.5%-0.9%, surplus are glycerine.
Comprising a kind of preparation of skin barrier remediation composition, by weight percentage by 6.5%~30% skin barrier
Remediation composition and surplus are made up of pharmaceutic adjuvant.
The formulation of above-mentioned preparation is preferably gel, aqua, ointment or cream.
It is demonstrated experimentally that formulation made of the skin barrier remediation composition of the present invention is by skin moisture-keeping, supplementing oil
Content, can effectively remissive treatment via laser beautifying, tartaric acid change redness after the beauty means such as skin caused by skin, heat pain, take off skin,
The symptoms such as itch, assimilation effect is good, can also improve sensitive skin.Preparation method is simple, with short production cycle, and prescription is simplified, cost
It is low.
Embodiment
With reference to specific embodiment, the present invention is further illustrated.
Embodiment 1
A kind of skin barrier remediation composition, by weight percentage by 10% trehalose, 10% Sodium Polyacrylate and 80%
Glycerine forms.
Embodiment 2
A kind of skin barrier remediation composition, by weight percentage by 0.05% trehalose and 0.1% Sodium Polyacrylate and
99.85% glycerine forms.
Embodiment 3
A kind of skin barrier remediation composition, by weight percentage by 1% trehalose and 0.9% Sodium Polyacrylate and
98.1% glycerine forms.
Embodiment 4
A kind of skin barrier remediation composition, by weight percentage by 0.5% trehalose and 0.5% Sodium Polyacrylate and
99% glycerine forms.
Embodiment 5
Comprising a kind of gel of skin barrier remediation composition, it is made up of following methods：
(1) a kind of skin barrier remediation composition, 3g niacinamide, 1g carbomers, the 1g tri- of the preparation of 30g embodiments 1 are weighed
Monoethanolamine and 65g water；
(2) niacinamide, carbomer, triethanolamine are well mixed, heating water bath adds a kind of skin barrier and repaiied to 80 DEG C
Compound composition and water, stir, be well mixed, be cooled to 40 DEG C, sterilizing, produce.
Embodiment 6
Comprising a kind of gel of skin barrier remediation composition, it is made up of following methods：
(1) a kind of skin barrier remediation composition, 2g niacinamide, 0.8g carbomers, the 1g of the preparation of 20g embodiments 2 are weighed
Triethanolamine and 76.2g water；
(2) niacinamide, carbomer, triethanolamine are well mixed, heating water bath adds a kind of skin barrier and repaiied to 80 DEG C
Compound composition and water, stir, be well mixed, be cooled to 40 DEG C, sterilizing, produce.
Embodiment 7
Comprising a kind of gel of skin barrier remediation composition, it is made up of following methods：
(1) weigh 23g embodiments 3 preparation a kind of skin barrier remediation composition, 2g niacinamide, 0.8g carbomers,
0.8g triethanolamines and 73.4g water；
(2) niacinamide, carbomer, triethanolamine are well mixed, heating water bath adds a kind of skin barrier and repaiied to 80 DEG C
Compound composition and water, stir, be well mixed, be cooled to 40 DEG C, sterilizing, produce.
Embodiment 8
Comprising a kind of gel of skin barrier remediation composition, it is made up of following methods：
(1) a kind of skin barrier remediation composition, 3g niacinamide, 0.8g carbomers, the 1g of the preparation of 6.5g embodiments 4 are weighed
Triethanolamine and 88.7g water；
(2) niacinamide, carbomer, triethanolamine are well mixed, heating water bath adds a kind of skin barrier and repaiied to 80 DEG C
Compound composition and water, stir, be well mixed, be cooled to 40 DEG C, sterilizing, produce.
Embodiment 9
Comprising a kind of cream of skin barrier remediation composition, it is made up of following methods：
(1) a kind of skin barrier remediation composition, 10g olive oil, 3g propane diols, the 3g ten of the preparation of 30g embodiments 1 are weighed
Eight alcohol, 4g mixed fatty glycerides and 50g water；
(2) olive oil, propane diols, octadecyl alcolol, mixed fatty glycerides are well mixed, heating water bath obtains to 70 DEG C
To mixture 1；
(3) take another container to be well mixed a kind of skin barrier remediation composition and water, be heated to 70 DEG C, mixed
Thing 2, mixture 1 is added in mixture 2 under processing condition, homogeneous 5-10 minutes, is cooled to 30-40 DEG C, sterilized, i.e.,
.
Embodiment 10
Comprising a kind of ointment of skin barrier remediation composition, it is made up of following methods：
(1) a kind of skin barrier remediation composition, 0.8g carbomers, the ethanol of 0.8g tri- of the preparation of 20g embodiments 1 are weighed
Amine, 3.4g cera albas and 75g water；
(2) carbomer, triethanolamine and cera alba are well mixed, heating water bath adds a kind of skin barrier to 80 DEG C
Remediation composition and water, stir, and are cooled to 40 DEG C, sterilizing, produce.
Embodiment 11
Comprising a kind of aqua of skin barrier remediation composition, it is made up of following methods：
(1) weigh 6.5g embodiments 1 preparation a kind of skin barrier remediation composition, 15g maltose, 15g niacinamide and
63.5g water is made；
(2) by a kind of skin barrier remediation composition, maltose, niacinamide and water, it is well mixed, is heated to 80 DEG C, protects
Warm 20min, 40 DEG C are cooled to, sterilizing, is produced.
Compare 1 group：Embodiment 11 in Chinese patent 201410588132.0.
According to a kind of formula (wound repair hydrocolloid, by quality by trehalose 5%, sodium carboxymethylcellulose of embodiment 3
6%th, 1,3 butanediols 20% and purified water 69% form), trehalose, sodium carboxymethylcellulose, NMF and purified water are heated
To 85 DEG C, make it well mixed with 20rpm speed stirring during heating；It is continuously heating to open vacuum at 90 DEG C, vacuum-
0.05-0Mpa, homogeneous rotating speed 4000rpm, homogeneous 8 minutes, 40 minutes are incubated at 70 DEG C after homogeneous, then are cooled to room temperature, obtained
Hydrocolloid intermediate, it is filling after intermediate detection is qualified, canned hydrocolloid is subjected to sterilization treatment, finished product detection, bag
Dress.
Compare 2 groups：Embodiment 8 in Chinese patent 201610214919.X
(1) by embodiment 3, (a kind of sebum film maintenance composition, is made up of following raw materials by mass percentage：Hyaluronic acid
Sodium 0.3%, trehalose 2%, (glycerine and butanediol mass ratio are 2 to NMF:3) 10%, grease (Butyrospermum parkii fruit fat and breast wood
The mass ratio of fruit oil is 1:1) 3%, Sodium Polyacrylate 0.8% and sodium-chloride water solution 83.9%, (the quality of sodium-chloride water solution
0.9%) concentration is.
Compare 3 groups：The compound method of the prescription of embodiment 8 and embodiment 14 in Chinese patent 201410588382.4.
Prescription is：
Comprising a kind of paste of skin barrier remediation composition, by weight percentage by a kind of (the skin screen of 25% embodiment 1
Hinder remediation composition, be made up of by weight percentage 10% trehalose and 90% sodium carboxymethylcellulose.) prepare a kind of skin
Skin barrier remediation composition, 25% glycerine, 25% propane diols and 25%PEG 400 are made.
Preparation method：
By pharmaceutically acceptable auxiliary material heating water bath to 80 DEG C, make it well mixed, then add composition skin barrier and repair
The trehalose and sodium carboxymethylcellulose of compound composition, stirring make its suspended dispersed.40 DEG C are cooled to, is filled and is encapsulated in closed appearance
Sterilizing chamber is sent into device and carries out 60Coradiation sterilizing, is provided according to medicine after completing irradiation sterilization, that is, is made and includes a kind of skin
The paste of barrier remediation composition.
Embodiment 12
Skin surface moisture after the invention is used via skinanalysis apparatus measurement.
The people of volunteer 130 is chosen, is divided into 13 groups, every group of 10 people, a diameter of 3cm circle is drawn on arm inside skin,
Each group embodiment product, reference product 0.05ml are smeared, basic number is tested using German CK skinanalysis apparatus MC760 moisturizings probe
Value (using preceding humidity), 4 hours humidity of skin (using rear humidity) data such as following tables.
Table 1, compared using front and rear humidity of skin
| Group | Use preceding humidity | Use rear humidity |
| 5 groups of embodiment | 31.57±3.85 | 75.74±4.31* |
| 6 groups of embodiment | 32.41±4.38 | 76.48±4.43* |
| 7 groups of embodiment | 31.58±3.87 | 74.87±4.28* |
| 8 groups of embodiment | 32.05±5.38 | 75.22±5.34* |
| 9 groups of embodiment | 32.09±4.29 | 75.69±4.39* |
| 10 groups of embodiment | 33.68±4.67 | 74.38±5.08* |
| 11 groups of embodiment | 33.95±5.98 | 75.41±4.06* |
| Trehalose | 32.05±4.92 | 39.67±5.98 |
| Sodium Polyacrylate | 30.91±5.61 | 35.47±6.34 |
| Glycerine | 34.67±5.39 | 42.59±3.52 |
| Compare 1 group | 31.52±3.94 | 49.53±3.82 |
| Compare 2 groups | 32.07±4.98 | 70.59±4.18 |
| Compare 3 groups | 31.82±3.87 | 48.57±4.54 |
* with compareing 2 groups than P ＜ 0.05
Embodiment 13
140 Balb/c male mices are taken, back depilation, are cleaned out with physiological saline.1% yellow Jackets of mouse
After intraperitoneal injection of anesthesia, dorsal injection epirubicin (2mg/ml).The mouse for forming the exedens surface of a wound is randomly divided into 14 groups, sky
White control group does not make any processing, and each group is first cleaned a wound, with sterile after smearing before corresponding experiment product is smeared with physiological saline
Gauze is fixed and bound up a wound, and every dressing in 2 days 1 time, observes wound healing situation.
Do not heal Wound healing rate=(original surface of a wound area-surface of a wound area)/original surface of a wound area.For the original surface of a wound and
Do not heal the method that the surface of a wound draws surface of a wound shape with transparent graph paper, with image J software processing pictures, calculates wound healing
Rate.
The surface of a wound situation table of table 2
* with compareing 2 groups than P ＜ 0.05
Embodiment 14
Clinical test
It is chosen at that hospital changes skin via tartaric acid, crystallite grinding, laser anti-acne, laser are dispelled skin caused by the beauty means such as melanin
Red and swollen heat pain of skin etc..Totally 400, wherein male 85, women 315, age 18-52 year, average age (28.6 ± 7.1)
Year.It is divided into 10 groups.
Treatment method：Product of the present invention is given by treatment group；Control group is divided into 3 groups and uses corresponding product respectively.To prescription
Method is：After cleaning cutaneous lesion, use, the 1st day to the 10th day, daily using 1 time, the 10th day to 20 days, every other day using 1 time,
Each coating time is 20 minutes.
Evaluation index：With reference to《New Chinese medicine guideline of clinical investigations》, carry out clinical evaluation.Carried out by same observer
The observation of skin severity scale and adverse events.
Clinical performance symptom and sign is evaluated and grade scale
Symptom score is carried out with reference to the sensitive dermatitis standard of face:Erythema, oedema, ooze out, shouting pain, pigmentation respectively by
Without, it is light, in, restatement be 0-3 points.
Specially：
Erythema：Erythema color it is scarlet or it is dark red meter 3 points；Obvious erythema meter 2 divides；Light red spot meter 1 divides；Without color change meter 0
Point.
Oedema：3 points of corium oedema infiltration meter occurs for extensive region；Many places occur clear and definite corium oedema meter 2 and divided；Partial zones
Domain corium oedema is not easy to be touched 1 point of meter；Divide without oedema meter 0.
Ooze out：Ooze out it is obvious that the scope matter of fundamental importance 3 is divided；Ooze out more apparent, scope is divided compared with subtotal 2；Point-like is seen after examining
Ooze out 1 point of meter；0 point is counted without oozing out.
Shouting pain：Continue tingling sensation, 3 points of meter can not be endured；Continue or be interrupted tingling sensation, 2 points of meter can be endured；Once in a while, slightly
Shouting pain meter 1 divides；Divide without tingling sensation meter 0.
Pigmentation：Pigmentation is it is obvious that scope is divided compared with the matter of fundamental importance 3；Pigmentation is more apparent, and scope is divided compared with subtotal 2；It is young
Visible slight pigmentation meter 1 divides after thin observation；Calm 0 point of the meter of non-pigment.
Curative effect evaluation standard：According to recovery from illness, effective, effective, invalid four standards.
Therapeutic index=[being integrated before (being integrated before treatment after integration-treatment) ÷ treatments] × 100%
Recovery from illness:Therapeutic index >=95%；It is effective:70%≤therapeutic index ＜ 95%；Effectively:30%≤therapeutic index ＜
70%；It is invalid:Therapeutic index ＜ 30%.Total effective rate=(recovery from illness number of cases+effective number of cases+effective number of cases) ÷ total number of cases ×
100%.
Safety evaluatio：The appearance that has no adverse reaction has been examined during Clinical practice, has conscientiously been recorded, and has followed the trail of sight
Examine, if finding, patient has uncomfortable reaction, should interrupt treatment immediately, and actively take symptomatic treatment.To there is clinical meaning
Adverse events, need follow-up to symptom to disappear, and record.
Table 3, each group therapeutic evaluation
| Group | Cure | It is effective | Effectively | It is invalid | It is efficient |
| 5 groups of embodiment | 34 | 2 | 1 | 3 | 92.5% |
| 6 groups of embodiment | 31 | 4 | 3 | 2 | 95% |
| 7 groups of embodiment | 29 | 5 | 4 | 2 | 95% |
| 8 groups of embodiment | 30 | 5 | 2 | 3 | 92.5% |
| 9 groups of embodiment | 32 | 2 | 3 | 3 | 92.5% |
| 10 groups of embodiment | 31 | 3 | 4 | 2 | 95% |
| 11 groups of embodiment | 31 | 5 | 2 | 2 | 95% |
| Compare 1 group | 18 | 7 | 7 | 8 | 80% |
| Compare 2 groups | 18 | 9 | 8 | 5 | 87.5% |
| Compare 3 groups | 10 | 12 | 6 | 12 | 70% |
Skin barrier function detects：Using German CK companies Multi probe skin measurement system MPA9, CM825 (moisture measurement
Probe) and TM300 (water loss test probe) detection water content of stratum corneum and transepidermal water loss amount (TEWL).In constant temperature and humidity
Under the conditions of be measured, 20-25 DEG C of room temperature, relative humidity 40%-60%, testee cleans skin to be measured simultaneously before detection
30min enters quiet to be measured in test environment in advance, detects the non-cutaneous lesion of cheek respectively.
Table 4, skin transepidermal water loss amount (TEWL) and water content of stratum corneum compare
| Group | Transepidermal water loss amount | Water content of stratum corneum |
| 5 groups of embodiment | 6.57±3.57* | 39.51±5.37* |
| 6 groups of embodiment | 7.21±2.37* | 36.95±6.57* |
| 7 groups of embodiment | 8.57±3.21* | 37.06±5.22* |
| 8 groups of embodiment | 7.69±2.53* | 38.20±6.07* |
| 9 groups of embodiment | 7.32±2.06* | 37.26±5.42* |
| 10 groups of embodiment | 7.15±2.41* | 37.91±5.49* |
| 11 groups of embodiment | 7.48±2.59* | 38.75±5.56* |
| Compare 1 group | 12.62±4.93 | 32.47±5.23 |
| Compare 2 groups | 11.67±6.86 | 31.72±4.31 |
| Compare 3 groups | 14.40±2.35 | 30.27±4.08 |
*With compareing 2 groups than P ＜ 0.05
Comparison (the ug/cm of table 5, pretherapy and post-treatment skin oil and fat amount2)
| Group | Before treatment | After treatment |
| 5 groups of embodiment | 81.72±6.12 | 112.84±6.27* |
| 6 groups of embodiment | 82.97±5.87 | 113.57±7.28* |
| 7 groups of embodiment | 81.87±6.31 | 114.26±5.38* |
| 8 groups of embodiment | 82.58±5.07 | 112.67±6.37* |
| 9 groups of embodiment | 80.39±5.39 | 113.40±5.84* |
| 10 groups of embodiment | 81.26±5.41 | 114.29±5.49* |
| 11 groups of embodiment | 80.61±5.60 | 115.59±6.08* |
| Compare 1 group | 81.67±4.91 | 95.27±5.37 |
| Compare 2 groups | 81.25±5.36 | 94.79±6.28 |
| Compare 3 groups | 80.86±5.34 | 94.79±6.36 |
*With compareing 2 groups than P ＜ 0.05.
Claims (4)
- A kind of 1. skin barrier remediation composition, it is characterized in that being made up of by weight percentage following raw materials：Trehalose 0.05%- 10%, Sodium Polyacrylate 0.1%-10%, surplus is glycerine.
- A kind of 2. skin barrier remediation composition according to claim 1, it is characterized in that the trehalose is 0.5%- 1%, Sodium Polyacrylate 0.5%-0.9%, surplus is glycerine.
- 3. comprising claim 1 or 2 a kind of skin barrier remediation composition preparation, it is characterized in that by weight percentage by 6.5%~30% skin barrier remediation composition and surplus is made up of pharmaceutic adjuvant.
- A kind of 4. preparation of skin barrier remediation composition according to claim 3, it is characterized in that the agent of described preparation Type is gel, aqua, ointment or cream.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476647A (en) * | 2021-08-17 | 2021-10-08 | 上海迪派生物科技有限公司 | Trehalose gel dressing and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726366A (en) * | 2016-04-07 | 2016-07-06 | 天津嘉氏堂医美科技有限公司 | Skin surface lipid film healing composition |
| CN106511220A (en) * | 2016-12-30 | 2017-03-22 | 广东国方医药科技有限公司 | Dendrobium officinale moisturizing and repair sleeping mask and preparation method thereof |
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2017
- 2017-08-11 CN CN201710685213.6A patent/CN107375012A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726366A (en) * | 2016-04-07 | 2016-07-06 | 天津嘉氏堂医美科技有限公司 | Skin surface lipid film healing composition |
| CN106511220A (en) * | 2016-12-30 | 2017-03-22 | 广东国方医药科技有限公司 | Dendrobium officinale moisturizing and repair sleeping mask and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113476647A (en) * | 2021-08-17 | 2021-10-08 | 上海迪派生物科技有限公司 | Trehalose gel dressing and preparation method thereof |
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Application publication date: 20171124 |