CN105726366A - Skin surface lipid film healing composition - Google Patents
Skin surface lipid film healing composition Download PDFInfo
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- CN105726366A CN105726366A CN201610214951.8A CN201610214951A CN105726366A CN 105726366 A CN105726366 A CN 105726366A CN 201610214951 A CN201610214951 A CN 201610214951A CN 105726366 A CN105726366 A CN 105726366A
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- trehalose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention discloses a skin surface lipid film healing composition.The skin surface lipid film healing composition is prepared from, by mass, 0.1-1% of sodium hyaluronate, 0.2-4% of trehalose, 2-15% of glycerinum, 1-10% of at least one of shea butter and avocado butter, 0.1-0.5% of sodium polyacrylate and 69.5-96.6% of water.An experiment proves that the skin surface lipid film healing composition can effectively relieve symptoms such as redness, swollenness, heat pain, skin peeling and pruritus caused after beautifying means such as laser beautifying and chemical peeling are performed on skin, and is good in absorption effect; no emulsifying agent is added in gel, the skin surface lipid film healing composition belongs to a non-emulsification system, the sensitized risk is lowered, the preparation method is simple, the production period is short, the formula is simple, and the cost is low.
Description
Technical field
The invention belongs to biomedicine technical field, be specifically related to a kind of sebum film remediation composition and containing this compositions
Preparation.
Background technology
Two during the last ten years, and along with deepening continuously of China's reform and opening-up, medical treatment shaping and beauty industry is a dark horse, and quickly grows,
Market is vigorous not to wane.21 century beauty treatment has become the life of young women required already.2014, beauty treatment mechanism of China market
Total capacity has reached 553,000,000,000 yuan, and wherein medical treatment shaping and beauty market accounts for the share of 3.8%, medical shaping and beauty in i.e. 2014
Industry whole nation total quantity consumed breaks through 21,000,000,000 yuan.Recent years, Chinese people are increasingly stronger to beautiful and fashion pursuit, I
State's beauty industry also will persistently keep quick growing trend.
The cardinal principle of laser beautifying be have employed useful to human body, through ability compared with the light wave-wave strong, tissue absorbance is high
Section, utilizes the weak laser stimulation to biological tissue, the effective face meridian point that stimulates, and acceleration blood circulation improves skin
The supply condition of skin, increases skin tissue's nutrition, promotes anabolism and the tissue repair of human body, thus it is dark to improve blee
Secretly, pigmentation, cutis laxa, wrinkle, eye pouch be sagging, black eye, corse sweat pore, pachylosis etc., makes skin of face
Ruddy gloss, elastic enhancing, the aging of delaying skin, play the effect of skin maintenance.But thing followed problem, also exists
Annoying these women liked to be beautiful compatriot, cause skin barrier impaired after laser beautifying, and then the diseases such as red, swollen, hot, pain occur
Shape annoyings these women compatriot.
The patent No. 200510042021.0 " for the trehalose of cosmetics and hyaluronic acid compositions and preparation method thereof " discloses
A kind of trehalose that can be used for cosmetics and the compositions of hyaluronic acid, and only explanation said composition has the effect of replenishing water and preserving moisture,
Said composition most preferably use ratio, the hyaluronate sodium effect of which kind of molecular weight more preferably and said composition other effects the most not
Open.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, it is provided that a kind of sebum film remediation composition.
Second object of the present invention is to provide a kind of gel containing sebum film remediation composition.
Technical scheme is summarized as follows:
Sebum film maintenance compositions, is made up of following raw material by mass percentage: hyaluronate sodium 0.1%-1%, trehalose 0.2%-4%,
At least one 1%-10% in glycerol 2%-15%, shea butter and Butyrospermum parkii fruit fat, sodium polyacrylate 0.1%-0.5% and water
69.5%-96.6%.
Preferably, hyaluronate sodium is 1:(2～5 by mass ratio): the molecular weight ranges of (5～30) is 1000000～2000000
Macromolecule hyaluronate sodium, the Middle molecule hyaluronate sodium of molecular weight ranges 100000～400000 and molecular weight ranges exist
The micromolecule hyaluronic acid sodium composition of 5000～10000.
Containing the gel of above-mentioned sebum film maintenance compositions, make by following method:
(1) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(2) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(3) mixture step (1) prepared adds in aqueous trehalose solution, is heated to 80-90 DEG C, adds shea butter and cattle
At least one in oil fruit tree fruit fat, stirs 10-30 minute；
(4) it is cooled to 30-40 DEG C, to obtain final product.
It is demonstrated experimentally that the sebum film remediation composition of the present invention, it is possible to effectively remissive treatment changes skin etc. via laser beautifying, fruit acid
The symptom such as redness caused by skin, burning pain, desquamation, pruritus after beauty treatment means, assimilation effect is good, and the gel of the present invention is not added with
Emulsifying agent, belongs to non-emulsified system, reduces the risk of sensitization, and preparation method is simple, and with short production cycle, prescription is simplified,
Low cost.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
A kind of sebum film remediation composition, is made up of following component by quality: hyaluronate sodium 0.1%, trehalose 0.2%, glycerol
2%, shea butter 1%, sodium polyacrylate 0.1% and water 96.6%.
The hyaluronic acid of the present embodiment by the molecular weight ranges that mass ratio is 1:2:30 1000000～1200000 macromolecule
Hyaluronic acid, the Middle molecule hyaluronic acid of molecular weight ranges 300000～400000 and molecular weight ranges 5000～7000 little
Molecular weight hyaluronic acid forms.
Embodiment 2
A kind of sebum film remediation composition, is made up of following component by quality: hyaluronate sodium 1%, trehalose 4%, glycerol 15%,
Butyrospermum parkii fruit fat in 10%, sodium polyacrylate 0.5% and water 69.5%.
The hyaluronic acid of the present embodiment by the molecular weight ranges that mass ratio is 1:5:5 1800000～2000000 macromolecule saturating
Bright matter acid, molecular weight ranges 100000～200000 Middle molecule hyaluronic acid and molecular weight ranges 8000～10000 little
Molecular weight hyaluronic acid forms.
Embodiment 3
A kind of sebum film remediation composition, is made up of following component by quality: hyaluronate sodium 0.3%, trehalose 2%, glycerol
10%, Butyrospermum parkii fruit fat and shea butter totally 3% (Butyrospermum parkii fruit fat is 1:1 with shea butter mass ratio), polyacrylic acid
Sodium 0.1% and water 84.6%.
The hyaluronic acid of the present embodiment by the molecular weight ranges that mass ratio is 1:4:15 1400000～1600000 macromolecule
Hyaluronic acid, molecular weight ranges 200000～300000 Middle molecule hyaluronic acid and molecular weight ranges 7000～8000
Micromolecule hyaluronic acid forms.
Embodiment 4
A kind of sebum film remediation composition, is made up of following component by quality: hyaluronate sodium 0.5%, trehalose 1%, glycerol
7%, Butyrospermum parkii fruit fat and shea butter totally 7% (Butyrospermum parkii fruit fat is 2:3 with shea butter mass ratio), polyacrylic acid
Sodium 0.2% and water 84.3%.
The hyaluronic acid of the present embodiment by the molecular weight ranges that mass ratio is 1:3:22 1700000～1800000 macromolecule
Hyaluronic acid, the Middle molecule hyaluronic acid of molecular weight ranges 200000～400000 and molecular weight ranges 6000～8000 little
Molecular weight hyaluronic acid forms.
Embodiment 5
Containing the gel of sebum film remediation composition, make by following method:
(1) each raw material is taken by embodiment 1；
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 80 DEG C, adds shea butter, stirs
Mix 10 minutes；
(5) it is cooled to 40 DEG C, to obtain final product.
Embodiment 6
Containing the gel of sebum film remediation composition, make by following method:
(1) each raw material is taken by embodiment 2；
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 90 DEG C, adds Butyrospermum parkii fruit fat,
Stir 10 minutes；
(5) it is cooled to 30 DEG C, to obtain final product.
Embodiment 7
Containing the gel of sebum film remediation composition, make by following method:
(1) each raw material is taken by embodiment 3；
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 85 DEG C, adds shea butter and cattle
Oil fruit tree fruit fat, stirs 20 minutes；
(5) it is cooled to 35 DEG C, to obtain final product.
Embodiment 8
Containing the gel of sebum film remediation composition, make by following method:
(1) each raw material is taken by embodiment 4；
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 82 DEG C, adds shea butter and cattle
Oil fruit tree fruit fat, stirs 30 minutes；
(5) it is cooled to 32 DEG C, to obtain final product.
Test:
Comparison liquid used in following test and preparation method thereof is as follows:
Compare 1 group: in Chinese patent ZL200510042021.0 as a example by embodiment 1, by trehalose 1.5g, hyaluronate sodium
0.2g (inventor finds through retrieval, 2005 and in the past, and the molecular weight of hyaluronate sodium is between 500000 to 2000000,
The hyaluronate sodium of this molecular weight section is chosen in the preparation of this comparison liquid), tween 0.2g, ethyl hydroxybenzoate 0.03g be dissolved in 98g water
In, obtain solution.
Compare 2 groups:
(1) take: 0.3g hyaluronic acid is (by the molecular weight ranges that mass ratio is 1:4:15 at big point of 1400000～1600000
Son amount hyaluronic acid, the Middle molecule hyaluronic acid of molecular weight ranges 200000～300000 and molecular weight ranges are 7000～8000
Micromolecule hyaluronic acid composition), 10g glycerol, Butyrospermum parkii fruit fat and shea butter 3g altogether (Butyrospermum parkii fruit fat and Butyrospermum Parkii
Oil quality ratio is 1:1), sodium polyacrylate 0.1g and water 86.6g.
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) mixture prepared by step (2) is added to the water, is heated to 85 DEG C, add shea butter and Butyrospermum parkii fruit fat,
Stir 20 minutes；
(4) it is cooled to 35 DEG C, to obtain final product.
Compare 3 groups
(1) trehalose 2g, glycerol 10g, Butyrospermum parkii fruit fat and shea butter 3g altogether (Butyrospermum parkii fruit fat and Butyrospermum Parkii are taken
Oil quality ratio is 1:1), sodium polyacrylate 0.1g and water 84.9g.
(2) sodium polyacrylate is mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 85 DEG C, adds shea butter and cattle
Oil fruit tree fruit fat, stirs 20 minutes；
(5) it is cooled to 35 DEG C, to obtain final product.
Compare 4 groups
(1) take: 0.3g molecular weight is the hyaluronate sodium of 1400000～1600000,2g trehalose, 10g glycerol, Adeps Bovis seu Bubali
Fruit tree fruit fat and shea butter 3g altogether (Butyrospermum parkii fruit fat is 1:1 with shea butter mass ratio), sodium polyacrylate 0.1g and
Water 84.6g；
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 85 DEG C, adds shea butter and cattle
Oil fruit tree fruit fat, stirs 20 minutes；
(5) it is cooled to 35 DEG C, to obtain final product.
Compare 5 groups
(1) take: 0.3g molecular weight is the hyaluronate sodium of 200000～300000,2g trehalose, 10g glycerol, shea
Tree fruit fat and shea butter 3g altogether (Butyrospermum parkii fruit fat is 1:1 with shea butter mass ratio), sodium polyacrylate 0.1g and water
84.6g；
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 85 DEG C, adds shea butter and cattle
Oil fruit tree fruit fat, stirs 20 minutes；
(5) it is cooled to 35 DEG C, to obtain final product.
Compare 6 groups
(1) take: 0.3g molecular weight is the hyaluronate sodium of 6000～8000,2g trehalose, 10g glycerol, Butyrospermum parkii fruit
Fat and shea butter 3g altogether (Butyrospermum parkii fruit fat is 1:1 with shea butter mass ratio), sodium polyacrylate 0.1g and water 84.6g；
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 85 DEG C, adds shea butter and cattle
Oil fruit tree fruit fat, stirs 20 minutes；
(5) it is cooled to 35 DEG C, to obtain final product.
Compare 7 groups
(1) take: (middle-molecular-weihydroxyethyl hyaluronate sodium is 3:1 with the mass ratio of macromolecule hyaluronate sodium to 0.3g hyaluronate sodium
, the molecular weight of middle-molecular-weihydroxyethyl hyaluronate sodium is 300,000 400000, and the molecular weight of macromolecule hyaluronate sodium is
1000000 1200000), 2g trehalose, 17g glycerol, Butyrospermum parkii fruit fat and shea butter 3g altogether (Butyrospermum parkii fruit fat with
Shea butter mass ratio is 1:1), sodium polyacrylate 0.1g and water 80.6g；
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 85 DEG C, adds shea butter and cattle
Oil fruit tree fruit fat, stirs 20 minutes；
(5) it is cooled to 35 DEG C, to obtain final product.
Compare 8 groups
(1) take: 0.3g hyaluronate sodium (macromolecule hyaluronate sodium is 4:13 with the mass ratio of small-molecular-weight hyaluronate sodium,
The molecular weight of macromolecule hyaluronate sodium is 1,200,000 1400000, and the molecular weight of small-molecular-weight hyaluronate sodium is
5000 6000), 2g trehalose, 10g glycerol, Butyrospermum parkii fruit fat and shea butter 3g altogether (Butyrospermum parkii fruit fat and Butyrospermum Parkii
Oil quality ratio is 1:1), sodium polyacrylate 0.1g and water 84.6g；
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 85 DEG C, adds shea butter and cattle
Oil fruit tree fruit fat, stirs 20 minutes；
(5) it is cooled to 35 DEG C, to obtain final product.
Compare 9 groups
(1) take: 0.3g hyaluronate sodium (middle-molecular-weihydroxyethyl hyaluronate sodium is 2:7 with the mass ratio of small-molecular-weight hyaluronate sodium,
The molecular weight of middle-molecular-weihydroxyethyl hyaluronate sodium is 200,000 300000, and the molecular weight of small-molecular-weight hyaluronate sodium is
6000 7000), 2g trehalose, 10g glycerol, Butyrospermum parkii fruit fat and shea butter 3g altogether (Butyrospermum parkii fruit fat and Butyrospermum Parkii
Oil quality ratio is 1:1), sodium polyacrylate 0.1g and water 84.6g
(2) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(3) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(4) mixture step (2) prepared adds in aqueous trehalose solution, is heated to 85 DEG C, adds shea butter and cattle
Oil fruit tree fruit fat, stirs 20 minutes；
(5) it is cooled to 35 DEG C, to obtain final product.
Embodiment 9
Skin permeation test in vitro
Take the Kunming mouse that quality is 18-22g, slough abdominal part and the back of the body with the sodium sulfide solution that mass concentration is 0.08g/mL
Portion is by hair, and de-neck is put to death, and cuts skin of abdomen respectively, removes the fat on skin and subcutaneous tissue, the most with normal saline
Secondary flushing, filter paper blots surface moisture, and with the repeated multiple times flushing of normal saline, filter paper blots surface moisture, is placed in normal saline
In, 4 DEG C of Refrigerator stores are standby.
Transdermal Absorption tester temperature chamber adds water, sets in temperature chamber water temperature as (37 ± 0.1) DEG C, setting reception tank
The magnetic agitation speed of rotor is 40r/min, is fixed on by the skin clip of mice between confession medicine pond and the reception tank of diffusion,
Upwards, skin corium faces down stratum corneum side, drains bubble.
Taking 0.5mL experiment product (facial mask liquid prepared by each embodiment and comparison liquid) and drop on mouse skin, area is about 1cm2,
Respectively at 1h, 2h, 4h, 6h, take the liquid 1ml in reception tank, and supply by purified water in reception tank.
According to method HPLC of " Chinese Pharmacopoeia (the 4th) " (2015 editions), the content of trehalose is measured.Calculate tired
Meter transdermal absorption factor.
This experiment has a following experimental group: embodiment 5 groups, embodiment 6 groups, embodiment 7 groups, embodiment 8 groups, compare 1 group,
Compare 2 groups, compare 3 groups, compare 4 groups, compare 5 groups, compare 6 groups, compare 7 groups, compare 8 groups, compare 9 groups.
Table 1, skin permeation test in vitro trehalose transmitance
| 1h | 2h | 4h | 6h | |
| Compare 1 group | 1.25% | 8.75% | 15.39% | 21.42% |
| Compare 2 groups | 1.36% | 17.64% | 28.68% | 40.38% |
| Compare 3 groups | 1.26% | 17.39% | 27.46% | 40.29% |
| Compare 4 groups | 1.93% | 17.84% | 27.91% | 41.09% |
| Compare 5 groups | 1.42% | 17.39% | 27.13% | 41.62% |
| Compare 6 groups | 1.39% | 17.46% | 27.39% | 41.71% |
| Compare 7 groups | 1.72% | 17.69% | 26.39% | 41.21% |
| Compare 8 groups | 1.38% | 17.38% | 26.84% | 41.48% |
| Compare 9 groups | 1.58% | 17.01% | 26.34% | 41.09% |
| Embodiment 5 groups | 7.26% | 21.27% | 39.16% | 52.48% |
| Embodiment 6 groups | 6.38% | 21.39% | 39.49% | 53.41% |
| Embodiment 7 groups | 8.71% | 22.04% | 40.16% | 54.17% |
| Embodiment 8 groups | 7.39% | 21.18% | 39.52% | 52.80% |
As can be seen from the above table, the compositions that the sebum film of the present invention is repaired, energy preferably percutaneous absorbtion, and time the longest effect
The best, accumulative transit dose is the highest, though and compare 1-9 group and have a transdermal absorption of hyaluronic acid, but inhale from the transdermal of any time period
The compositions transmitance all not having the present invention from the point of view of yield is high.
Embodiment 10
CK skinanalysis apparatus is used to measure skin moisture-keeping degree.
Select volunteer 260 people, be randomly divided into 13 groups, often organize 20 people, clean arm, dry, measure the basis of now skin
Value, takes experiment product (facial mask liquid prepared by each embodiment and comparison liquid) 0.05mL uniform application in 1cm2Skin on, measure 0h,
1h, 2h, 4h skin moisture-keeping.
Table 2, moistening effect result of the test
*Compare with compareing 1 group, P ＜ 0.01
△ with compare 2 groups of ratios, P ＜ 0.05
By the present invention it can be seen that comparison 1 group instant moistening effect after smearing is the best, comparison 4-9 group selects different molecular weight
Hyaluronate sodium also can reach good moistening effect, but embodiment 5-8 group is an advantage over compareing 4-9 group from data
's.
Embodiment 11
The clinical verification of the present invention be chosen at the beautifying medical mechanism people such as hospital through face laser, that fruit acid changes skin, micro-shaping etc. is micro-
Create postoperative skin and damaged skin that the reason such as sensitive skin, dermatitis causes.In 260 clinical example sufferers, women
212 examples, male 48 example, the age is 18-60 year.It is randomly divided into 13 groups, often organizes 20 people.
This experiment has a following experimental group: embodiment 5 groups；Embodiment 6 groups；Embodiment 7 groups；Embodiment 8 groups；Compare 1 group；
Compare 2 groups；Compare 3 groups；Compare 4 groups；Compare 5 groups；Compare 6 groups；Compare 7 groups；Compare 8 groups；Compare 9 groups.
Using method: (1) based process: cleaning cutaneous lesion.(2) use product, uniform application in cutaneous lesion, very thin one
Layer, three times a day, can be increased or decreased consumption according to patient's practical situation.It within 20 days, it was 1 course for the treatment of.
Health giving quality index: carry out with reference to the sensitive dermatitis standard of face[1,2]Symptom score: pruritus, erythema, edema, ooze out, be dried
Desquamation, twinge, pigmentation respectively by without, light, in, restatement be 03 points.
Note: [1] jade. the clinical research [D] of antipruritic skin gels treatment facial dermatitis. Shandong Traditional Chinese Medicine University, 2012. [2] Liu Dongmei, Shen Weilu, Wang Kun,
Deng. face is through changing skin and the clinical treatment [J] of skin care postoperative skin sensitivity. China's combination of Chinese and Western medicine skin cypridology magazine, and 2012,11 (6): 365-367.
According to symptom, somatic feature score before and after treatment, with reference to " new Chinese medicine guideline of clinical investigations ", treat by following standard
Effect is evaluated:
Recovery from illness: symptom, somatic feature score reduce >=95%.
Effective: pain symptom, somatic feature score reduce>=70%,<95%.
Effective: symptom, somatic feature score reduce>=30%,<70%.
Invalid: symptom, sign reduce less than 30%.
Recovery from illness+effective+effective number of cases calculates total effective rate.
Computing formula is: [integration before (integration after integration-treatment before treatment)/treatment] × 100%.
Safety evaluatio:
In normal conditions of use, by the clinical practice of experimenter, it is determined that with or without the generation of adverse events, and according to bad thing
The degree of part, and vital sign checks for exception, is evaluated Product Safety.
I level: safety, without any adverse events, vital sign checks without exception.
II grade: compare safety, have slight adverse events, be not required to do any process can continual cure, vital sign checks without exception.
III grade: have safety issue, there is moderate adverse events, can continual cure or vital sign inspection have after processing
Mile abnormality.
IV grade: because serious adverse events stops test, or vital sign checks the most abnormal.
Table 3 experimental result
| Use medicine | Case load | Recovery from illness | Effective | Effectively | Invalid | Effective percentage | Safety evaluatio |
| Compare 1 group | 20 | 3 | 5 | 6 | 6 | 35.00% | II grade |
| Compare 2 groups | 20 | 2 | 3 | 5 | 10 | 50.00% | II grade |
| Compare 3 groups | 20 | 2 | 3 | 4 | 11 | 45.00% | II grade |
| Compare 4 groups | 20 | 4 | 3 | 5 | 8 | 60.00% | II grade |
| Compare 5 groups | 20 | 6 | 4 | 3 | 7 | 65.00% | I level |
| Compare 6 groups | 20 | 7 | 3 | 3 | 7 | 65.00% | I level |
| Compare 7 groups | 20 | 5 | 4 | 6 | 7 | 65.00% | I level |
| Compare 8 groups | 20 | 6 | 4 | 4 | 6 | 70.00% | I level |
| Compare 9 groups | 20 | 6 | 5 | 3 | 6 | 70.00% | I level |
| Embodiment 5 groups | 20 | 16 | 2 | 0 | 2 | 90.00% | I level |
| Embodiment 6 groups | 20 | 16 | 1 | 1 | 2 | 90.00% | I level |
| Embodiment 7 groups | 20 | 17 | 0 | 2 | 1 | 95.00% | I level |
| Embodiment 8 groups | 20 | 16 | 1 | 1 | 2 | 90.00% | I level |
By above-mentioned clinical trial it can be seen that the product effective percentage of the present invention is more than 90.00%, achieve certain curative effect, its
The using effect of middle embodiment 5-8 group is more effective than matched group, and embodiment 7 (optimum trehalose and hyaluronate sodium
Ratio) effect is best, illustrates that the sebum film remediation composition of the present invention changes skin, micro-whole for people through face laser, fruit acid
The damaged skin that skin after the invasive surgeries such as shape and the reason such as sensitive skin, dermatitis cause has good effect.
Safety evaluatio result: embodiment 5-8 group, all there is not adverse events in comparison 5-9 group, vital sign checks without exception,
Compare 1 group have 3 example patients to occur there is punctation in red and swollen aggravation or face, take a turn for the better after drug withdrawal；Compare 2 groups and have 1 example patient
Occur being dried desquamation symptom, take a turn for the better after treatment；Compareing 3 groups has 2 example patients facial red heat occur, and pain is the best
Turn；Compareing 4 groups has 1 example patient facial swelling occur, takes a turn for the better after drug withdrawal.
Above example only have expressed the detailed description of the invention of the present invention, and it describes more concrete and in detail, but can not therefore and
It is interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that, for the person of ordinary skill of the art, do not taking off
On the premise of present inventive concept, it is also possible to make some deformation and improvement, these broadly fall into protection scope of the present invention.
Claims (3)
1. sebum film maintenance compositions, is characterized in that being made up of following raw material by mass percentage: hyaluronate sodium 0.1%-1%, Sargassum
At least one 1%-10% in sugar 0.2%-4%, glycerol 2%-15%, shea butter and Butyrospermum parkii fruit fat, sodium polyacrylate
0.1%-0.5% and water 69.5%-96.6%.
Sebum film maintenance compositions the most according to claim 1, is characterized in that described hyaluronate sodium is 1:(2～5 by mass ratio):
The molecular weight ranges of (5～30) 1000000～2000000 macromolecule hyaluronate sodium, molecular weight ranges 100000～
The Middle molecule hyaluronate sodium of 400000 and molecular weight ranges form at the micromolecule hyaluronic acid sodium of 5000～10000.
3. the gel containing claim 1 or 2 sebum film maintenance compositions, is characterized in that making by following method:
(1) hyaluronate sodium, sodium polyacrylate are mixed homogeneously with glycerol；
(2) trehalose is mixed with water, make trehalose dissolve, obtain aqueous trehalose solution；
(3) mixture step (1) prepared adds in aqueous trehalose solution, is heated to 80-90 DEG C, adds shea butter and cattle
At least one in oil fruit tree fruit fat, stirs 10-30 minute；
(4) it is cooled to 30-40 DEG C, to obtain final product.
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| CN106389139A (en) * | 2016-11-22 | 2017-02-15 | 河南工业大学 | Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof |
| CN107375032A (en) * | 2017-08-11 | 2017-11-24 | 天津嘉氏堂科技有限公司 | A kind of composition and preparation method for repairing skin barrier |
| CN107375012A (en) * | 2017-08-11 | 2017-11-24 | 天津嘉氏堂科技有限公司 | A kind of skin barrier remediation composition and preparation |
| CN107412255A (en) * | 2017-08-11 | 2017-12-01 | 天津嘉氏堂科技有限公司 | Skin barrier remediation composition and preparation |
| CN114732844A (en) * | 2021-11-09 | 2022-07-12 | 西安润玉医疗科技有限公司 | Immediate allergy-relieving bionic membrane composition and preparation method thereof |
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| CN105726366B (en) | 2018-03-27 |
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Effective date of registration: 20211210 Address after: 300480 No. 453 Hengshan Road, modern industrial zone, economic and Technological Development Zone, Binhai New Area, Tianjin Patentee after: TIANJIN CACHET TECHNOLOGY CO.,LTD. Address before: 300457 east of Hengshan Road, south of Changhong street and west of PUFA Xingye project, Hangu modern industrial zone, economic and Technological Development Zone, Binhai New Area, Tianjin Patentee before: TIANJIN JIASHITANG MEDICAL TECHNOLOGY CO.,LTD. |