CN106994137A - Uygur medicine composition for treating hyperuricemia and gout and its preparation method and application - Google Patents
Uygur medicine composition for treating hyperuricemia and gout and its preparation method and application Download PDFInfo
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Abstract
The invention provides Uygur medicine composition for treating hyperuricemia and gout and its preparation method and application.The present composition is with witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, fennel seeds, foreign fennel, the Uygur such as fennel seeds root skin and celery seed oil medicinal material is raw material, can effectively treat the symptoms such as hyperuricemia and gout, new selection is provided for clinical application.Meanwhile, in the inventive method, by the way that with mixing and adding auxiliary agent prepared by extracts active ingredients into different dosage forms medicine, have the advantages that processing step is easy.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, in particular to the Uygur for treating hyperuricemia and gout
Drug composition and its preparation method and application.
Background technology
Hyperuricemia (Hyperur icemi a, HUA) refers under normal diet state, by purine metabolic disturbance, urine
Acid generation increases and/or drains reduction, and caused uric acid is accumulated in vivo, and causes the elevated shape of uric acid concentration in blood
State.Uric acid is the final product of purine catabolism, and it is excreted by kidney with urine.Uric acid has two kinds of existence forms, one
It is enol form for keto-acid, one.The alcohol of formula structure of uric acid has acidity, is often drained with salt forms such as its sodium, potassium in urine.It is strong
Uric acid content is about 1.1g in health adult body, wherein about 15% is present in blood, uric acid in blood is through glomerulus mistake
It is most of by reabsorption after filter.Uric acid is one of important component of nonprotein nitrogen in internal blood plasma, is seriously damaged in kidney
During evil, uric acid in blood can be raised significantly, and reason is that Patients With Kidney Diseases, due to renal failure, metabolic disorder, cause blood urine
Acid increases.In addition, causing the reason for uric acid in blood is raised to also have：The kidney trouble of excretory function decline, starvation, medicine are indiscriminate
With, excessive drinking and use of some drugses etc..
Uric acid change is little in body when kidney is slightly damaged, thus, changes of serum uric acid is to diagnose the impaired sensitivity of kidney severe
Index.Internal blood uric acid, which increases, can cause fat metabolism, glycometabolism and disorder of amino acid metabolism, and cause Endothelial Dysfunction or
The increase of inflammatory factor；Meanwhile, hyperuricemia is extremely closely related with general metabolism, is also angiocardiopathy, diabetes, kidney
The high risk factor of property disease.Thus, based on metabonomic technology the characteristics of and advantage, hyperuricemia metabonomic analysis just by
Step embodies increasing clinical value, and uric acid level rise can make cardiovascular disease incidence rate and death rate increase.
Traditional anti-trioxypurine medicine mainly reduces uric acid level in blood by suppressing uric acid synthesis or promoting uric acid excretion,
So as to reduce calmness of the uric acid in tissue, therapeutic action is played.Numerous studies since half a century show that hyperuricemia is
Major Risk Factors in the disease developments such as hypertension, dyslipidemia, obesity, insulin resistance and diabetes.High lithemia
Level, is to predict one of important indicator of Index for diagnosis of metabolic syndrome.Metabolic Syndrome Patients redox is lacked of proper care, and high
Uric acid level can promote metabolic syndrome oxidative stress.Although the important function that uric acid is played in Antioxidative Defense System, together
When uric acid level rise also have inoxidizability protective effect, still, metabolic syndrome occur evolution in, oxidation should
Sharp toxic action is still in the highest flight.
Hyperuricemia (hyperur icemia) is the pathologic basis of gout, when internal uric acid concentration is higher than saturated concentration
417 μm of ol/L, will form crystallization deposition to tissue, joint and kidney, form gout.((gout) is throat cry of certain animals class material to gout
Metabolic disorder, serum Uric Acid Concentration persistently increases, one group of metabolic disease caused by urate crystal deposition soft tissue.Clinical upper table
Now for hyperuricemia (Hyperur icemia), gouty acute arthritis, tophaceous deposition, characteristic chornic arthritis and
Arthritis deformans, often involve kidney, cause arteriosclerotic kidney and kidney calculus urate, and urarthritis is often the syndrome
First presentation.
Seriously, long-term gout repeatedly breaking-out, can caused by joint tissue fibrosis and tophus articular cartilage,
The deposition of synovial membrane, ligament, makes lesion joint gradually damaged deformation, loses motor function, and with multiple complications, it is also possible to draw
Send out the ill effects such as renal failure.The normal recurrent exerbation of the state of an illness, does not recover for a long time, and has certain difficulty in the treatment yet.Gout can
It is divided into primary and the major class of Secondary cases two.Secondary gout is due to that some diseases or medicine cause underexcretion, so that
The gout formed caused by hyperuricemia.Primary gout pathogenic factors mainly has underexcretion and generation to increase two sides
Face, primary gout is generally divided into asymptomatic stage, acute arthritis phase, intermittent phase and chornic arthritis phase.
In recent years, with the improvement of people ' s living standards, the change of dietary structure and habits and customs, gout and antihyperuricemic
The incidence of disease of disease constantly rises, and age of onset becomes younger, especially in developed regions, and the gout incidence of disease in China's affluence city is obvious
Higher than rural area, huge burden is brought to society.The therapeutic purposes of hyperuricemia are to avoid occurring acute gouty arthritis,
Infringement of the hyperuricemia to internal organs such as heart and brain is eliminated, recovers the normal interior environment of body, it, which is treated, mainly includes diet and medicine
Thing.Meanwhile, degree and the serum uric acid level increasing of the possibility and lesion that also occur evidence suggests hyperuricemia complication
High degree is proportional, and complication is often lifelong disease.Thus, the early stage of blood uric acid and strict control seem very
It is important.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is a kind of Uygur medicine composition for being used to treat hyperuricemia and gout of offer,
The present composition can effectively treat the symptoms such as hyperuricemia and gout, and new selection is provided for clinical application.
The second object of the present invention is to provide a kind of Uygur medicine group for being used to treat hyperuricemia and gout
In the preparation method of compound, this method, by by extracts active ingredients and mix and add auxiliary agent to prepare different dosage forms medicine,
Have the advantages that processing step is easy.
Third object of the present invention be to provide I your drug composition prepare treatment hyperuricemia and
Application in gout medicine.The present composition can effectively treat the symptoms such as hyperuricemia and gout, it is thus possible to be used for
Prepare corresponding disease therapeuticing medicine.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
It is a kind of to be used to treating the Uygur medicine composition of hyperuricemia and gout, the Uygur medicine composition it is main by
Following raw material is made：
Witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, fennel seeds, foreign fennel, fennel seeds root skin and celery seed
Oil.
Optionally, in the present invention, in parts by weight, the Uygur medicine composition is mainly made up of following raw material：
1~100 part of witloof seed, 1~100 part of cichory root, 1~100 part of celery seed, 1~100 part of Herba Apii graveolentis root, Semen Cuscutae 1~
100 parts, 1~100 part of fennel seeds, 1~100 part of foreign fennel, 1~100 part of fennel seeds root skin, and 1~10 part of celery seed oil.
Optionally, in the present invention, in parts by weight, the Uygur medicine composition is mainly made up of following raw material：
1~50 part of witloof seed, 1~90 part of cichory root, 1~50 part of celery seed, 1~50 part of Herba Apii graveolentis root, Semen Cuscutae 1~30
Part, 1~50 part of fennel seeds, 1~50 part of foreign fennel, 1~50 part of fennel seeds root skin, and 1~8 part of celery seed oil.
Optionally, in the present invention, in parts by weight, the Uygur medicine composition is mainly made up of following raw material：
1~45 part of witloof seed, 1~35 part of cichory root, 1~15 part of celery seed, 1~30 part of Herba Apii graveolentis root, Semen Cuscutae 1~15
Part, 1~15 part of fennel seeds, 1~10 part of foreign fennel, 1~15 part of fennel seeds root skin, and 1~5 part of celery seed oil.
Optionally, in the present invention, it is clinical or pharmaceutically acceptable any formulation that the Uygur medicine composition, which is,；
It is preferred that, the Uygur medicine composition be suppository, gel, capsule, effervescent tablet, patch, pill, powder, pulvis,
Lotion, oral disintegrating tablet, film, emulsion, emulsifiable paste, ointment, enema, or spray.
Meanwhile, present invention also offers the preparation method of the Uygur medicine composition, methods described comprises the following steps：
By witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, and fennel seeds root skin grinding and sieving, then return
Stream is extracted, and is evaporated after filtering, is obtained dry extract；
Fennel seeds and foreign fennel volatile oil are extracted, is then mixed with celery seed oil, it is dry with medicinal extract after beta-cyclodextrin inclusion compound
Powder is mixed, and then adds auxiliary material and clinical or pharmaceutically acceptable any formulation is made；
It is preferred that, the formulation be granule, tablet, capsule, effervescent tablet, oral liquid, pill, powder, pulvis, honey ointment,
Or massecuite.
Optionally, in the present invention, the refluxing extraction is the refluxing extraction that adds water, and extraction time is 4~6h, and is extracted 2 times；
It is preferred that, the quality of water used is by witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, and fennel seeds
10 times of root skin quality.
Optionally, in the present invention, the refluxing extraction is addition ethanol water refluxing extraction；
It is preferred that, the concentration of the ethanol water is 30~90vol%.
Likewise, preparing treatment hyperuricemia and gout medicine present invention also offers the Uygur medicine composition
In application.
Further, present invention provides the medicine comprising Uygur medicine composition of the present invention or pharmaceutical composition.
Compared with prior art, beneficial effects of the present invention are：
(1) composition of the present invention is with natural plants/extract, and the main method with physics carries out active ingredient and carried
Take and raw material mixing and the preparation of corresponding formulation, it is thus possible to be effectively retained the natural constituent in raw material, and for
Hyperuricemia and gout have good therapeutic effect；Meanwhile, for synthetic drug, Uygur medicine group of the present invention
Compound Small side effects, it is adaptable to the crowd in all ages and classes stage, will not also occur antagonism with other drugs.
(2) preparation method step of the present invention is easy, and preparation technology flow is simple, suitable for industrial-scale production.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or the unreceipted production firm person of instrument, be
The conventional products that can be obtained by commercially available purchase.
Uygur medicine composition of the present invention is made up of following raw material：Witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Tu thread
Son, fennel seeds, foreign fennel, fennel seeds root skin, and celery seed oil；
It is preferred that, in parts by weight, each raw material dosage is as follows：1~100 part of witloof seed, for example can be, but do not limit
In 2,5,10,15,20,30,40,45,50,60,70,80, or 90 parts etc.；1~100 part of cichory root, for example can be, but not
It is limited to 2,10,15,20,30,35,50,60,70,80, or 90 parts etc.；1~100 part of celery seed, for example can be, but do not limit
In 2,5,10,15,20,30,40,50,60,70,80, or 90 parts etc.；1~100 part of Herba Apii graveolentis root, for example can be, but do not limit
In 2,5,10,15,20,30,40,50,60,70,80, or 90 parts etc.；1~100 part of Semen Cuscutae, for example can be, but do not limit
In 2,5,10,15,20,30,40,50,60,70,80, or 90 parts etc.；1~100 part of fennel seeds, for example can be, but do not limit
In 2,10,15,30,40,50,60,70,80, or 90 parts etc.；1~100 part of foreign fennel, for example can be, but be not limited to 2,
10th, 20,30,40,50,60,70,80, or 90 parts etc.；1~100 part of fennel seeds root skin, for example can be, but be not limited to 2,
10th, 15,30,40,50,60,70,80, or 90 parts etc.；1~10 part of celery seed oil, for example can be, but be not limited to 2,3,4,
5th, 6,7,8, or 9 parts etc..
Wherein, witloof seed:It is dry cold, 1.《Visit according to medicine book》:" dry, fever and chills are flat.”2.《Crude drug pandect):" two grades are done
It is cold, it is believed that fever and chills are flat.Raw dry raw cold, dysregulation blood matter opens liver resistance, and heat clearing and inflammation relieving eliminates jaundice, diuresis
Detumescence.Humid or blood matter disease are cured mainly, such as liver blocks, and humid hepatitis, icterepatitis, anasarca is small
Just it is unfavorable etc..1.《Visit according to medicine book》:" bile matter typhoid fever is eliminated, liver resistance is opened, eliminates typhoid fever etc..Bile matter typhoid fever is controlled,
Liver resistance jaundice etc..”2.《Medicine it is secret》:" Sheng bile matter and blood matter were reduced, leads to resistance diuresis, treats various liver diseases etc..Control
Take liquid matter and blood matter is superfluous, liver resistance ascites, hepatitis, the chronic typhoid fever of liver void complexity etc..”3.《Crude drug pandect》:" open arteries and veins
Resistance, tonneau urine, clearing away heat to and alleviating pain is calmed the nerves except throbbing with fear, brings down a fever and quench the thirst, and is detoxified, hypnosis etc.；Control sering life resistance, difficult urination, hot head
Bitterly, palpitaition is had palpitation, thirsty, various poisonings of having a fever, with the passing of time insomnia etc..
Cichory root:It is raw, bitter.Raw humidogene is trembled with fear, dysregulation bile matter, reduces irascibility, and the heat of clearing stomach eliminates jaundice,
Diuresis detumescence.Cure mainly xeothermic property or bile matter disease, heating property hepatitis, gastritis, splenomegaly, jaundice, renal shutdown oedema.1.《In vain
Color palace》:" heat-clearing bushing, except calming the nerves unbearably, anti-inflammatory detumescence etc..Hot palpitaition is controlled, has palpitation, has a guilty conscience, sphagitis swells, eye is red and swollen
Deng.”2.《Visit according to medicine book》:" regression typhoid fever, opens liver and hinders, clearing heat and detoxicating etc..Typhoid fever is controlled, liver has retardance, drug poisoning, poison
Insect bite etc..
Celery seed:Two grades of xeothermic, bitters.Raw dry heat, dispelling cold diuresis is led to and prevents pain, and stomach strengthening and digestion promoting grasps wet stimulate the menstrual flow.It is main
Raw property or lymphatic temperament disease are controlled, such as cold difficult urination, raw property cures mainly raw property or lymphatic temperament disease, such as cold
Difficult urination, wet abdominal pain due to cold, hypochondriac pain, indigestion, anorexia, irregular menstruation.1.《Visit according to medicine book》:" enhancing sexual desire.
Control hyposexuality.”2.《The garden of medicine》:" warm lung is relievingd asthma, and drop check is told, and dispelling wind and arresting itching, nti-freckle blazes.Cold asthma is controlled, is disliked
The heart is vomitted, various scalls, flat wart, blackspot etc..”
Herba Apii graveolentis root:Three-level is xeothermic.1.《Visit according to medicine book》:" two grades xeothermic.”2.《The garden of medicine》:" two grades of head are xeothermic.It is raw
Dry heat, leads to resistance diuresis, and cold-dispelling pain-relieving removes abnormal humour.Raw property or lymphatic temperament disease are cured mainly, such as cold urine not
Profit, the raw various pain of property, internal abnormal humour increases.1.《Visit according to medicine book》:" softening organ opens arteries and veins resistance, cold removing profit
Urine, eliminates Dian Epilepsy, hysteria etc..Control organ sclerosis, sering life resistance, cold renal shutdown , Dian Epilepsy, hysteria etc..”2.《The garden of medicine》:" disappear
Scorching improving eyesight, relieving asthma, warm waist analgesic, more cancer is stopped blooding, and establishing-Yang of whetting the appetite improves cathartic effect, opens the resistance of liver and spleen, stimulate the menstrual flow and fall
Tire, calculus dissolving and excreting, regression measles, cold removing, which stops, to be trembled, removing toxic substances, wind-dispelling detumescence etc..
Semen Cuscutae:One-level does three-level heat, and slight bitter is puckery, ripe abnormal savda, calms the nerves except strongly fragrant, relieving restlessness solution is insane, leads to and prevents pain,
Regulating menstruation, hemostasis.The black various diseases of courage matter are cured mainly, such as depression, liver resistance yellow subcutaneous ulcer, the hard pain of stomach resistance is had sore throat, abdomen gastral cavity inflatable, the moon
Through excessive, visceral hemorrhage etc..《Visit according to medicine book》:" liver resistance is opened, the morbid substance of taste is removed, sering abnormal humour is removed,
Clear up and discharge complicated typhoid fever, drop check oh, mends stomach antidiarrheal, and diuresis is stimulated the menstrual flow, eliminating dampness stops band, wind-expelling pain-stopping etc.；Raw resistance in liver is controlled, taste are caused
Disease substance increases, and sering abnormal humour increases, lymphatic temperament and bile matter typhoid fever, hiccup, stomach void diarrhoea, difficult urination, warp
Water is not smooth, leucorrhea increasing, arthralgia etc..
Fennel seeds:Two grades xeothermic.Stomach invigorating, improving eyesight.Anorexia caused by hyperchylia is cured mainly, stomach cold abdominal distension is nauseous, oh
Inverse, visual impairment caused by brain void liver is empty, urethra caused by kidney deficiency is obstructed etc..1.《Note doctor's allusion quotation》:" obstruction is opened, improving eyesight is urged
Breast, only nauseous, diuresis is stimulated the menstrual flow, and is detoxified.”2.《White palace》:" improving eyesight, lactagogue, diuresis, stimulate the menstrual flow, only nausea, eliminate gastral cavilty not
Relax；Wild survivor can change kidney stone and vesical calculus.”3.《Visit according to medicine book》:" obstruction is opened, improving eyesight, which increases, to be regarded, lactagogue, removing toxic substances, profit
Urine, stimulates the menstrual flow, and dissipates gas, eliminates various typhoid fever, only nausea, eliminates gastritis, changes kidney stone and vesical calculus, warm stomach eliminating dampness.”4.《Medicine
Wu Zhi gardens》:" and lead to the obstruction of the organs such as chest, liver,spleen,kidney, bladder, cold pain is eliminated, strengthens eyesight, gastral cavilty is nourished, dissipated
Dense gas and dense property body fluid, lactogenesis increase breast, and diuresis is led to urine, detoxified, eliminating dampness, convergence, and calming heart revival is relieving cough and asthma, drops check
Rush down.”
Fennel seeds root skin:Two grades xeothermic, raw dry heat, and ripe exception lymphatic temperament dissipates gas detumescence, leads to and prevent pain, stimulate the menstrual flow logical
Urine, soft stool leads to intestines.Raw property or lymphatic temperament disease are cured mainly, such as raw property is various scorching swollen, the cold pain of two sides of body, aching pain in waist and back, amenorrhoea,
Close urine, old intestinal obstruction etc..《The garden of medicine》:" morbid substance is distributed, tonifying liver benefit spleen opens obstruction, and cold-dispelling pain-relieving mends stomach
Increasing is regarded, removing toxic substances etc.；Liver and spleen disease is controlled, liver,spleen,kidney, bladder life resistance, the cold pain of liver,spleen,kidney, bladder, gastral cavilty are weak, eyesight
Reduction, poisonous insect stings wound etc..”
Celery seed oil:Fat content enriches in celery seed, containing a variety of pharmacological components, with scattered gas, detumescence, profit
The effects such as urine, antitumor, anti-aging.
Meanwhile, the need for actual use, Uygur medicine composition can be clinical or pharmaceutically acceptable any
Formulation, for example, suppository, gel, capsule, effervescent tablet, patch, pill, powder, pulvis, lotion, oral disintegrating tablet, film, emulsion, breast
Cream, ointment, enema, or any of spray formulation.
The preparation method of Uygur medicine composition of the present invention mainly comprises the following steps：By witloof seed, cichory root, celery
Son, Herba Apii graveolentis root, Semen Cuscutae, and fennel seeds root skin grinding and sieving, then add distilled water or ethanol water are flowed back
Extract, it is preferred that the consumption of distilled water is treat refluxing extraction material quality ten times, the concentration of ethanol water used for 30~
90vol%；The control of the time of extraction preferably is in 4~6h, and preferred extraction 2 times.After gained extract solution suction filtration, preferably
It is evaporated by the way of water-bath, the temperature control of water-bath obtains dry extract at≤75 DEG C, further through drying and crushing
Afterwards, extract dry powder is obtained；
Fennel seeds and foreign fennel volatile oil are extracted, is then mixed with celery seed oil, it is dry with medicinal extract after beta-cyclodextrin inclusion compound
Powder is sufficiently mixed uniformly, then adds auxiliary material, and obtain granule, tablet, capsule, effervescent tablet, oral liquid, pill, powder, powder
Agent, honey ointment, or massecuite etc. be clinical or pharmaceutically acceptable any formulation, as drug target.
Because Uygur medicine composition of the present invention has good therapeutic action and effect for hyperuricemia and gout,
It can thus be further used as in hyperuricemia and gout medicine.
Further, Uygur medicine composition of the present invention can be used alone, and to treat hyperuricemia and pain
The relevant diseases such as wind；Or Uygur medicine composition of the present invention can be used cooperatively with other drugs, and for relevant disease
Treatment in.
Embodiment 1
According to parts by weight, 30 parts of witloof seeds are weighed respectively, 30 parts of cichory roots, 15 parts of celery seeds, 30 parts of Herba Apii graveolentis roots, 15 parts
Semen Cuscutae, 15 portions of fennel seeds, 10 parts of foreign fennels, 15 parts of fennel seeds root skins, and 5 parts of celery seed oils.
Then, it is prepared as follows pharmaceutical composition：
By witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, and fennel seeds root skin grinding and sieving, Ran Houjia
10 times of water 4~6h of refluxing extraction, and extract 2 times；It is evaporated after filtering at≤75 DEG C, obtains dry extract, then do dry extract
It is dry to crush, obtain extract dry powder；
Fennel seeds and foreign fennel volatile oil are extracted, is then mixed with celery seed oil, it is dry with medicinal extract after beta-cyclodextrin inclusion compound
Powder is mixed, and then adds auxiliary material and granule is made.
Embodiment 2
According to parts by weight, 45 parts of witloof seeds, 35 parts of cichory roots, 10 parts of celery seeds, 5 parts of Herba Apii graveolentis roots, 10 parts are weighed respectively
Semen Cuscutae, 5 portions of fennel seeds, 5 parts of foreign fennels, 10 parts of fennel seeds root skins, and 2 parts of celery seed oils.
Then, it is prepared as follows pharmaceutical composition：
By witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, and fennel seeds root skin grinding and sieving, Ran Houjia
10 times of water 4~6h of refluxing extraction, and extract 2 times；It is evaporated after filtering at≤75 DEG C, obtains dry extract, then do dry extract
It is dry to crush, obtain extract dry powder；
Fennel seeds and foreign fennel volatile oil are extracted, is then mixed with celery seed oil, it is dry with medicinal extract after beta-cyclodextrin inclusion compound
Powder is mixed, and then adds auxiliary material and oral liquid is made.
Embodiment 3
According to parts by weight, 50 parts of witloof seeds, 70 parts of cichory roots, 50 parts of celery seeds, 50 parts of Herba Apii graveolentis roots, 30 parts are weighed respectively
Semen Cuscutae, 50 portions of fennel seeds, 50 parts of foreign fennels, 50 parts of fennel seeds root skins, and 8 parts of celery seed oils.
Then, it is prepared as follows pharmaceutical composition：
By witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, and fennel seeds root skin grinding and sieving, Ran Houjia
10 times of 75%vol ethanol water 4~6h of refluxing extraction, and extract 2 times；It is evaporated after filtering at≤75 DEG C, obtains dry extract,
Then by dry extract drying and crushing, extract dry powder is obtained；
Fennel seeds and foreign fennel volatile oil are extracted, is then mixed with celery seed oil, it is dry with medicinal extract after beta-cyclodextrin inclusion compound
Powder is mixed, and then adds auxiliary material and tablet is made.
Embodiment 4
According to parts by weight, 80 parts of witloof seeds, 100 parts of cichory roots, 10 parts of celery seeds, 10 parts of Herba Apii graveolentis roots, 10 are weighed respectively
Part Semen Cuscutae, 80 portions of fennel seeds, 10 parts of foreign fennels, 60 parts of fennel seeds root skins, and 10 parts of celery seed oils.
Then, it is prepared as follows pharmaceutical composition：
By witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, and fennel seeds root skin grinding and sieving, Ran Houjia
10 times of water 4~6h of refluxing extraction, and extract 2 times；It is evaporated after filtering at≤75 DEG C, obtains dry extract, then do dry extract
It is dry to crush, obtain extract dry powder；
Fennel seeds and foreign fennel volatile oil are extracted, is then mixed with celery seed oil, it is dry with medicinal extract after beta-cyclodextrin inclusion compound
Powder is mixed, and then adds auxiliary material and granule is made.
Embodiment 5
According to parts by weight, 10 parts of witloof seeds, 10 parts of cichory roots, 80 parts of celery seeds, 80 parts of Herba Apii graveolentis roots, 70 parts are weighed respectively
Semen Cuscutae, 10 portions of fennel seeds, 70 parts of foreign fennels, 10 parts of fennel seeds root skins, and 2 parts of celery seed oils.
Then, it is prepared as follows pharmaceutical composition：
By witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, and fennel seeds root skin grinding and sieving, Ran Houjia
10 times of water 4~6h of refluxing extraction, and extract 2 times；It is evaporated after filtering at≤75 DEG C, obtains dry extract, then do dry extract
It is dry to crush, obtain extract dry powder；
Fennel seeds and foreign fennel volatile oil are extracted, is then mixed with celery seed oil, it is dry with medicinal extract after beta-cyclodextrin inclusion compound
Powder is mixed, and then adds auxiliary material and effervescent tablet is made.
Experimental example 1
Chronic gout and height are suffered to 5 groups using each dosage form composition prepared in 1-5 of the embodiment of the present invention respectively
(it is 60~70 years old to randomly select from the age to hematuria acid disease patient, after diagnosing with chronic gout and the sour disease patient of high hematuria, often
Group 50) (contained effectively component dose is identical in the daily institute's drug administration of each group patient) is treated, in the treatment of 12 weeks
Between after, the serum uric acid level of patient all significantly decreases, and the experimental results are shown inthe following table：
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
Many other changes and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of Uygur medicine composition for being used to treat hyperuricemia and gout, it is characterised in that the Uygur medicine group
Compound is mainly made up of following raw material：
Witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, fennel seeds, foreign fennel, fennel seeds root skin, and celery seed oil.
2. Uygur medicine composition according to claim 1, it is characterised in that in parts by weight, the Uygur
Drug composition is mainly made up of following raw material：
1~100 part of witloof seed, 1~100 part of cichory root, 1~100 part of celery seed, 1~100 part of Herba Apii graveolentis root, Semen Cuscutae 1~100
Part, 1~100 part of fennel seeds, 1~100 part of foreign fennel, 1~100 part of fennel seeds root skin, and 1~10 part of celery seed oil.
3. Uygur medicine composition according to claim 2, it is characterised in that in parts by weight, the Uygur
Drug composition is mainly made up of following raw material：
1~50 part of witloof seed, 1~90 part of cichory root, 1~50 part of celery seed, 1~50 part of Herba Apii graveolentis root, 1~30 part of Semen Cuscutae is small
1~50 part of fennel, 1~50 part of foreign fennel, 1~50 part of fennel seeds root skin, and 1~8 part of celery seed oil.
4. Uygur medicine composition according to claim 3, it is characterised in that in parts by weight, the Uygur
Drug composition is mainly made up of following raw material：
1~45 part of witloof seed, 1~35 part of cichory root, 1~15 part of celery seed, 1~30 part of Herba Apii graveolentis root, 1~15 part of Semen Cuscutae is small
1~15 part of fennel, 1~10 part of foreign fennel, 1~15 part of fennel seeds root skin, and 1~5 part of celery seed oil.
5. the Uygur medicine composition according to any one of claim 1-4, it is characterised in that the Uygur medicine combination
Thing is clinical or pharmaceutically acceptable any formulation；
It is preferred that, the Uygur medicine composition is suppository, gel, capsule, effervescent tablet, patch, pill, powder, pulvis, washed
Agent, oral disintegrating tablet, film, emulsion, emulsifiable paste, ointment, enema, or spray.
6. the preparation method of Uygur medicine composition any one of claim 1-5, it is characterised in that methods described includes
Following steps：
By witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, and fennel seeds root skin grinding and sieving, it is then refluxed for carrying
Take, be evaporated after filtering, obtain dry extract；
Fennel seeds and foreign fennel volatile oil are extracted, is then mixed with celery seed oil, it is mixed with extract dry powder after beta-cyclodextrin inclusion compound
Close, then add auxiliary material and clinical or pharmaceutically acceptable any formulation is made；
It is preferred that, the formulation be granule, tablet, capsule, effervescent tablet, oral liquid, pill, powder, pulvis, honey ointment, or
Massecuite.
7. preparation method according to claim 6, it is characterised in that the refluxing extraction is the refluxing extraction that adds water, extraction
Time is 4~6h, and is extracted 2 times；
It is preferred that, the quality of water used is by witloof seed, cichory root, celery seed, Herba Apii graveolentis root, Semen Cuscutae, and fennel seeds root skin
10 times of quality.
8. preparation method according to claim 6, it is characterised in that the refluxing extraction flows back to add ethanol water
Extract；
It is preferred that, the concentration of the ethanol water is 30~90vol%.
9. Uygur medicine composition any one of claim 1-5 is in treatment hyperuricemia and gout medicine is prepared
Using.
10. include the medicine or pharmaceutical composition of Uygur medicine composition any one of claim 1-5.
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| CN107495340A (en) * | 2017-08-11 | 2017-12-22 | 安徽中森生物技术有限公司 | A kind of anti-trioxypurine diuretic compositions and preparation method thereof |
| CN109511984A (en) * | 2019-01-09 | 2019-03-26 | 丁强 | A kind of special dietary seafood with the alleviation gout that celery seed, potassium citrate etc. are primary raw material preparation |
| CN111658577A (en) * | 2020-07-28 | 2020-09-15 | 英丽(中山)生物科技有限公司 | Antibacterial volatile oil and preparation method thereof, antibacterial volatile oil freeze-dried powder, antibacterial agent and application |
| CN112353764A (en) * | 2020-06-15 | 2021-02-12 | 新疆维吾尔药业有限责任公司 | Bozuri hot granules and extraction method and application thereof |
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| CN105535048A (en) * | 2016-01-04 | 2016-05-04 | 中国科学院昆明植物研究所 | Application of celery seed extract to preparation of medicine or health-care food for resisting to hyperuricemia and gout |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107495340A (en) * | 2017-08-11 | 2017-12-22 | 安徽中森生物技术有限公司 | A kind of anti-trioxypurine diuretic compositions and preparation method thereof |
| CN109511984A (en) * | 2019-01-09 | 2019-03-26 | 丁强 | A kind of special dietary seafood with the alleviation gout that celery seed, potassium citrate etc. are primary raw material preparation |
| CN112353764A (en) * | 2020-06-15 | 2021-02-12 | 新疆维吾尔药业有限责任公司 | Bozuri hot granules and extraction method and application thereof |
| CN111658577A (en) * | 2020-07-28 | 2020-09-15 | 英丽(中山)生物科技有限公司 | Antibacterial volatile oil and preparation method thereof, antibacterial volatile oil freeze-dried powder, antibacterial agent and application |
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