CN107617081A - The Chinese medicine composition and its preparation and preparation method of a kind of hair growth - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition of hair growth and its pharmaceutical preparation, and it includes the bulk drug of following parts by weight：2.2~2.8 parts of the fleece-flower root, 1.2~1.8 parts of the Radix Astragali, even 1.2~1.8 parts of black drought, 0.8~1.2 part of the fruit of glossy privet, 1.5~2 parts of Ramulus Taxilli, 1.2~1.8 parts of the vine of multiflower knotweed, 1.8~2.2 parts of reticulate millettia, 1.2~1.8 parts of Common St.Paulswort Herb, 1.8~2.2 parts of ilex pubescens, 1.8~2.2 parts of serissa serissoide, 0.8~1.2 part of grass-leaved sweetflag, 0.8~1.2 part of fructus viticis, 0.8~1.2 part of psoralea corylifolia, 1.2~1.8 parts of the rhizome of davallia, 0.8~1.2 part of duckweed, 0.8~1.2 part of root tuber of aromatic turmeric, 0.8~1.2 part of cortex albiziae, 1.8~2.2 parts of mother-of-pearl.Each bulk drug in the Chinese medicine composition can act synergistically, and can not only effectively treat the illnesss such as alopecia areata, whole alopecia, general alopecia and postpartum, post disease alopecia, and effective relieving insomnia, stress etc. can merge symptom, evident in efficacy and Small side effects simultaneously.

Description

The Chinese medicine composition and its preparation and preparation method of a kind of hair growth

Technical field

The invention belongs to technical field of Chinese medicine, more particularly to one kind is treated alopecia areata, whole alopecia, general alopecia and postpartum, taken off after being ill Hair merges insomnia, nervous Chinese medicine composition, and its pharmaceutical preparation and preparation method.

Background technology

Alopecia areata is a kind of inflammatory chronic recurrent of non-cicatricial characterized by limitation circle alopecia occurred suddenly Hair loss disorders, the incidence of disease about 0.1%~0.2%.Alopecia areata can betide any age, and men and women's incidence of disease is without significant difference, and 1.7% ~2.0% people can undergo alopecia areata in life, and Most patients are younger, and 66% patient fell ill before 30 years old, only 20% patient is at 40 years old with sequela.

As economy develops rapidly, rhythm of life is increasingly accelerated, and the live and work pressure of people is huge, and environment is dirty in addition The factors such as dye exacerbation influence, and the alopecia areata incidence of disease improves year by year.Although alopecia areata is not disease that is fatal, disabling, to minimal invasive treatment Quality and psychiatric cause very big influence.Patients with alopecia areata not only poor image, or even cause psychological pressure, Chang Bingfa loses The symptoms such as dormancy, stress, normal work and life are influenceed, therefore controlled, treatment alopecia areata, have profound influence to patient.

At present, alopecia areata is considered as a kind of autoimmune disease of T cell mediateds, the immune privilege of normal hair follicle Function plays an important role by destroying during the occurrence and development of disease.Although research of the modern medicine to alopecia areata is more, But its etiology and pathogenesis, still indefinite so far, its cause of disease may be with inherent cause, immune dysfunction, psychoneural factor etc. Factor is relevant, while closely related with the factor such as the shortage of trace element and the obstacle of microcirculation.Clinically, take part more Injection glucocorticoid and outer the methods of putting immunodepressant on the skin.Although short term effect is pretty good, side effect is big, and because this disease is obstinate It is refractory, therefore recurrence rate is higher.

Traditional Chinese medicine has advantageous advantage in terms of alopecia areata is treated, and has more method, curative effect height, Small side effects, recurrence The advantages of rate is low.This disease is documented ancient Chinese medicine doctor and pathogenic analysis, can trace back to《The Yellow Emperor's Canon of Internal Medicine》With《It is difficult Through》In the epoch, such as exist《Interior warp》In have the names of disease such as " hair pulls out ", " hair de- ", " hair pendant ",《Hardly possible warp》Referred to as " hair falls ", such as Sui Dynasty's nest Member side《The General Treatise on the Cause and Symptoms of Diseases》Say：" people has ailment said due to cold or exposure, is head, has partially at void, then falls, and muscle is withered, or such as money is big, or such as Refer to greatly, hair is not given birth to, and is not also itched, therefore the alopecia seborrhoeica of meaning ".Ming Dynasty's Chen Shigong exists《Surgery is authentic》In initiate " alopecia areata " name, it is believed that This " is that the deficiency of blood can not be with the flourish foster skin of gas, therefore hair root is empty, departs from flakes, skin Lightening, formicant itching, all wind-heat is taken advantage of a weak point in opponent's defence for this Attack note and it is right." traditional Chinese medical science thinks blood stored in the liver, sends out as more than blood, Shen controls bone, its honor is being sent out, the deficiency of blood can not be with the foster skin of its honor, therefore hair Fall in flakes.Therefore it is clinical more using nourishing the liver and kidney, the regulation of qi and blood as main principle of reatment, more using kidney tonifying, blood-nourishing, promoting blood circulation and cool blood Chinese medicine and acupuncture, massage method, its mechanism of action may include regulation immunity of organism, improve microcirculation, regulation nerve point System etc. is secreted, this is consistent with doctor trained in Western medicine to the understanding of the sick pathogenesis and orientation treatment.Interior Zhiduo County from liver kidney, Qi and blood opinion control, control to tonify the liver and kidney, nourishing qi and blood, soothing liver-qi stagnation, method promoting blood circulation and removing blood stasis；Washed, made by oneself using medicinal fuming in outer Zhiduo County Tincture and external preparation smear affected part, medicine is directly acted on part；The complex treatment of the traditional Chinese medical science, by medicine oral administration and externally, pin Effective therapy conjunctive use of the different action pathway such as thorn, cave note and physical treatment, increases curative effect, reduces side effect.

Although traditional Chinese medicine existing many document records in terms of alopecia areata is treated, the alopecia areata improved year by year for the reply incidence of disease, The illness such as whole alopecia, general alopecia and postpartum, post disease alopecia, the specific mechanism of Chinese medicine alopecia areata and the screening of effective Chinese medicine still need Further further investigation, the effect of to provide more preferable therapeutic modality and Geng Gao, especially also need to take into account concurrent insomnia and essence The symptoms such as refreshing anxiety.

The content of the invention

The first object of the present invention is to provide a kind of curative effect height, treatment alopecia areata, whole alopecia, general alopecia and the production of Small side effects Afterwards, post disease alopecia merges insomnia, nervous Chinese medicine composition.The Chinese medicine composition includes the bulk drug of following parts by weight：

2.2~2.8 parts of the fleece-flower root (system), 1.2~1.8 parts of the Radix Astragali, ink drought connect 1.2~1.8 parts, the fruit of glossy privet 0.8~1.2 Part, 1.5~2 parts of Ramulus Taxilli, 1.2~1.8 parts of the vine of multiflower knotweed, 1.2~1.8 parts of the Fen, Common St.Paulswort Herbs of reticulate millettia 1.8~2.2, ilex pubescens 1.8~2.2 parts, 1.8~2.2 parts of serissa serissoide, 0.8~1.2 part of grass-leaved sweetflag, 0.8~1.2 part of fructus viticis, psoralea corylifolia 0.8~1.2 Part, 1.2~1.8 parts of the rhizome of davallia, 0.8~1.2 part of duckweed, 0.8~1.2 part of root tuber of aromatic turmeric, 0.8~1.2 part of cortex albiziae, mother-of-pearl 1.8 ~2.2 parts.

Preferably, the fleece-flower root (system) be 2.5 parts, the Radix Astragali be 1.5 parts, black drought be linked as 1.5 parts, the fruit of glossy privet be 1 part, Ramulus Taxilli Be 1.5 parts for 1.75 parts, the vine of multiflower knotweed, reticulate millettia be 2 Fen, Common St.Paulswort Herbs be 1.5 parts, ilex pubescens is 2 parts, serissa serissoide is 2 parts, stone Chang Pu is 1 part, fructus viticis is 1 part, psoralea corylifolia is 1 part, the rhizome of davallia is 1.5 parts, duckweed is 1 part, root tuber of aromatic turmeric is 1 part, cortex albiziae 1 Part, mother-of-pearl are 2 parts.

The second object of the present invention is to provide a kind of pharmaceutical preparation using described Chinese medicine composition as active ingredient (compound fleece-flower root germinal preparation).The pharmaceutical preparation is the conventional agent being prepared into using this area customary preparation methods in pharmacy Type.The pharmaceutical preparation can be water pill, granule, electuary, powder, glue oral liquid.

The third object of the present invention is the preparation method for providing described pharmaceutical preparation, including step：By each of prescription Bulk drug mixing after, using 5~10 times amount water carry out decoction 0.3~2.5 hour, Steam pressure control be 0.02MPa~ 0.15MPa, decoction can be filtered out after decoction.

In one preferred embodiment of the method for the invention, after each bulk drug is rinsed with water and soak more than 2 hours, often After pressure decocts 20 minutes, the decoction filtered out is the decoction that can be taken.

In another preferred embodiment of the method for the invention, using 7~10 times of amount water during decoction, it is small to decoct 1.5~2.5 When after the decoction that filters out be head juice；Add 4~8 times of amount water and carry out secondary decoction, the decoction filtered out after 1.5~2.5 hours is Two juice；After merging head juice and two juice then filtering and concentrating obtains to the clear cream that relative density is 1.08~1.12 after general ball, drying To water pill.

Further, during each bulk drug mixing, it is ground into after in advance mixing the fleece-flower root, the fruit of glossy privet, the rhizome of davallia, duckweed thin Powder crosses 100 mesh sieves and obtains mixed powder；Mixed powder and clear cream molding are used during general ball.

In another preferred embodiment of the method for the invention, each bulk drug is rinsed before decocting with water and to soak 2~4 small When, after normal pressure decocts 20~40 minutes, decoction is filtered out, dextrin and Icing Sugar are added after concentration, with 70% ethanol softwood, mistake after mixing No. 1 sieve series grain, 40~60 DEG C are dried to obtain granule.

Certainly, using this area customary preparation methods, using the Chinese medicine composition or with the mixture of its extraction such as The above-mentioned decoction filtered out, pharmaceutically acceptable carrier is added, other various different dosage forms can also be made.

The present invention is using nourishing the liver and kidney, the regulation of qi and blood this principle of reatment as foundation, there is provided pharmaceutical preparation can significantly change The clinical symptoms of kind patient, and toxic side effect is small, merges for alopecia areata, whole alopecia, general alopecia and postpartum, post disease alopecia and has a sleepless night, be spiritual tight A kind of more preferable therapeutic modality of offer opened.

In the prescription of the present invention, the fleece-flower root (system), the Radix Astragali, ink drought company, the fruit of glossy privet, Ramulus Taxilli are combined into monarch drug in a prescription, the vine of multiflower knotweed, Reticulate millettia, Common St.Paulswort Herbs, ilex pubescens, serissa serissoide, grass-leaved sweetflag, psoralea corylifolia, the rhizome of davallia, duckweed, cortex albiziae, mother-of-pearl are combined into minister Medicine, fructus viticis, duckweed, root tuber of aromatic turmeric, cortex albiziae synthesis adjutant.

The nature and flavor of every medicine, channel tropism and function are as follows in the prescription of the present invention：

The fleece-flower root (system)：Gas is micro-, taste micro-sweet and it is bitter.Return liver, the heart, kidney channel.Function filling liver kidney, benefiting essence-blood, black beard and hair, by force Muscles and bones effect.For blood deficiency chlorosis, dizziness and tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, under uterine bleeding band, chronic malaria body void.

The Radix Astragali：It is sweet, tepor.Return lung, spleen, liver and kidney channel.Function invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic.For the deficiency of vital energy The long disunion of weak, rush down prolapse of the anus for a long time, spontaneous perspiration, oedema, sub-official prolapses, chronic rephrilis protinuria, diabetes, the open sore part.

Black non-irrigated lotus：It is sweet, sour, tremble with fear.Return kidney, Liver Channel.Major function：It is nourishing liver and kidney, cooling blood and hemostasis.For tooth mobility, Poliosis, dizziness and tinnitus, soreness and weakness of waist and knees, YinXuXueRe, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, metrostaxis, traumatism and bleeding.

The fruit of glossy privet：It is cool in nature, it is sweet, bitter.Return kidney, Liver Channel.Major function：Nourishing liver and kidney, improving eyesight black hair.For dizziness ear Ring, soreness and weakness of waist and knees, poliosis, mesh are secretly failed to understand.

Ramulus Taxilli：Bitter but sweet flavor, put down.Return liver and kidney channel.Function filling liver kidney, strengthening the bones and muscles, curing rheumatism, degrading the channel are beneficial blood, antiabortive. For soreness of waist and knee joint, muscles and bones impotence is weak, hemiplegia, tinea pedis, wind-cold-dampness arthralgia, threatened abortion metrorrhagia, lack of lactation after delivery.It is vertical, dizzy to control chronic cough, tongue It is dizzy.

The vine of multiflower knotweed：Nature and flavor：Sweet slight bitter, put down.The thoughts of returning home, Liver Channel.Function nourishing heart, calm the nerves, dredging collateral, wind-dispelling.For insomnia, labor Wound, hidrosis, deficiency of blood bodily pain, ulcer, scrofula, wind sore scabies tinea.

Reticulate millettia：Bitter in taste, micro-sweet, it is warm-natured.The thoughts of returning home, the spleen channel.Function is activated blood and relaxed tendons, nourishing blood for regulating menstruation.For it is numb in every limb, Quadriplegia, arthralgia pain due to rheumatism, women have through uncomfortable, dysmenorrhoea, amenorrhoea.

Herba Siegesbeckiae：Acrid flavour, hardship, it is cold in nature, return liver and kidney channel.It is function remove rheumatism, strong muscles and bones, clearing heat and detoxicating.For mammary gland The diseases such as inflammation, wind cold diarrhea, gastric disorder causing nausea vomiting.

Ilex pubescens：Acrid flavour, cold in nature, function is clearing heat and detoxicating, promoting blood circulation, dampness removing.For anemopyretic cold, dyspnea and cough due to lung-heat, pharyngalgia, breast Moth, swelling and aching of gum, chest impediment and cardialgia, hemiplegia, erysipelas, burn and scald, ulcer.

Serissa serissoide：Lightly seasoned, micro-pungent, it is cool.Function liver soothing and depression relief is clearing heat and promoting diuresis, detumescence and drawing out poison, relieving cough and reducing sputum.For acute Hepatitis, lumbago, skelalgia of rheumatism, Carbuncle swells dislikes sore, snake bite, splenasthenic diarrhea, infantile malnutrition, vaginal discharge diseases, mesh screen, acute appendicitis, rabies.

Grass-leaved sweetflag：Acrid flavour, tepor, the thoughts of returning home, liver, the spleen channel.Function dampness elimination appetizing, slit phlegm of having one's ideas straightened out, inducing resuscitation intelligence development.For gastral cavity ruffian Not hungry, apnea, coma epilepsy, forgetfulness and deafness.

Fructus viticis：Acrid flavour, hardship, cold nature.Return lung, bladder, Liver Channel.Function dissipates wind, and be slightly cold heat-clearing, frivolous up, main to dissipate The heresy of head, there is the effect of wind-expelling pain-stopping.It is dim for affection of exogenous wind-heat, headache and dizzy, red eye, swell pain, the head.

Psoralea corylifolia：Acrid flavour；It is bitter；It is warm-natured.Return kidney, pericardium channel, the spleen channel, stomach, lung channel.Function tonifying kidney and strengthening yang, astringent sperm contracting urine. Relievingd asthma for lumbago due to the kidney deficiency, frequent urination, infantile enuresis, kidney leakage, warming spleen and stopping diarrha, gas of receiving.

The rhizome of davallia：Bitter, temperature.Return liver and kidney channel.Function kidney tonifying, promoting blood circulation, hemostasis.For kidney deficiency chronic diarrhea and pain in the back, rheumatism numbness Bitterly, dentalgia, tinnitus, the bruise sudden strain of a muscle, bone fracture, appendicitis, alopecia areata, corn.

Duckweed：It is cold in nature, acrid flavour.Return lung passes through.Function sweating, wind-dispelling, water-filling, heat-clearing, removing toxic substances.For when row hot carbuncle, macula Impermeable, wind-heat pain rash, pruitus, oedema, Amenorrhea, sore tinea, erysipelas, scald.

Root tuber of aromatic turmeric：Property is worked hard, cool.It is included into the heart, lung, Liver Channel.Function promoting qi circulation and removing obstruction in the collateral, cool blood broken stasis of blood.For all pains of chest and abdomen side of body rib, It is demented to lose the heart, pyreticosis coma, spits blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood strangury, women's vicarious menstruation, jaundice.

Cortex albiziae：Nature and flavor are sweet, flat.The thoughts of returning home, Liver Channel.Function resolving stagnation for tranquilization, activating blood circulation and reducing swelling.For controlling melancholy insomnia, the mind Uneasiness, inside and outside large carbuncle, injury from falling down.

Mother-of-pearl：Property is salty, cold.Return liver, the heart channel of Hang-Shaoyin.Function is calming the liver, clears liver and improve vision, tranquillizing the mind by relieving convulsion.For controlling dizzy a, ear Ring, palpitaition, insomnia, demented, frightened epilepsy, spit blood, bleeding from five sense organs or subcutaneous tissue, metrorrhagia.

Beneficial effects of the present invention：In prescription of the present invention, the fleece-flower root (system), the Radix Astragali, black non-irrigated lotus, the fruit of glossy privet, Ramulus Taxilli, head Black rattan etc. focuses on nourishing the liver and kidney, and the regulation of qi and blood, qi and blood is vigorous, flourish can support scalp, improve subcutaneous capillary, liver kidney reconciles, then The solid pool of hair is flourish.Root tuber of aromatic turmeric, cortex albiziae, mother-of-pearl medicine composition there is soothing liver-qi stagnation, tranquilizing and allaying excitement, can cooperate with mainly into Point, play and promote hair growth, improve the simultaneous phenomenon of the hair loss patients such as anxiety, uneasy sleeping at night.By the Chinese traditional medicine composition of the present invention Thing prepare pharmaceutical preparation there is the effect of nourishing the liver and kidney, regulation of qi and blood, can not only effectively treat alopecia areata, whole alopecia, general alopecia and The illnesss such as postpartum, post disease alopecia, and can the effective alopecia simultaneous phenomenon such as relieving insomnia, stress simultaneously, it is evident in efficacy and Small side effects, the treatment method with TCM Features is provided for kidney deficiency and liver type patients with alopecia areata.Clinical statisticses result show by Pharmaceutical preparation treatment whole alopecia, general alopecia and postpartum, post disease alopecia prepared by the Chinese medicine composition of the present invention, and merge insomnia, essence The total effective rate of the simultaneous phenomenons such as refreshing anxiety is up to more than 93%, and especially decoction effect is more notable, and total effective rate is up to 96.7%.

Embodiment

Below in conjunction with specific embodiment, the present invention is described in detail, but the implementation of the present invention is not only limited to this.

The experimental method of unreceipted actual conditions in the following example, generally according to normal condition, or according to manufacturer Proposed condition.Medicinal material used in the embodiment of the present invention is the prepared slices of Chinese crude drugs that are commercially available or buying post-processing except as otherwise indicating.

The preparation of the general ball of the traditional Chinese medicine composition water of embodiment 1 (compound fleece-flower root hair-growth ballet)

Prescription (parts by weight)：2.5 parts of the fleece-flower root (system), 1.5 parts of the Radix Astragali, even 1.5 parts of ink drought, 1 part of the fruit of glossy privet, Ramulus Taxilli 1.75 parts, 1.5 parts of the vine of multiflower knotweed, 1.5 parts of the Fen, Common St.Paulswort Herbs of reticulate millettia 2,2 parts of ilex pubescens, 2 parts of serissa serissoide, 1 part of grass-leaved sweetflag, fructus viticis 1 part, 1 part of psoralea corylifolia, 1.5 parts of the rhizome of davallia, 1 part of duckweed, 1 part of root tuber of aromatic turmeric, 1 part of cortex albiziae, 2 parts of mother-of-pearl.

By above-mentioned prescription, it is placed in pulverizer after the fleece-flower root (system), the fruit of glossy privet, the rhizome of davallia, duckweed are mixed and is ground into fine powder. Fine powder crosses 100 mesh sieves and obtains standby mixed powder by 15 minutes total mixed batch is carried out.

1st, decoct

A certain amount of above-mentioned mixed powder input is extracted in pot, then puts into remaining net medicinal material of 14 tastes of prescription corresponding amount, About 8 times of amount water are added, are decocted 2 hours, head juice is released, filtration, inputs storage tank, it is standby；Residue adds the water of about 6 times of amounts, decocts Boil 2 hours, release two juice, filtration, input storage tank, it is standby.Extraction operation Steam pressure control 0.02MPa~0.15MPa it Between.Merge head, two juice, filtration, filtrate is concentrated into the clear cream that relative density is 1.10 (80 DEG C).

2nd, general ball

Mixed powder above-mentioned a little is put into the direct molding of clear cream after appropriate dilution is used in coating pan, or mixed with a little Powder adds appropriate clear cream, 12~14 mesh sieves is crossed after mixing particle is made, be put into coating pan mistake when increasing to maximum gauge 3.5mm Sieve.Untill continuing to be increased to 3.5mm less than 3.5mm, after more than 3.5mm and particle is not made with 12~14 mesh sieves in the pill of rounding Again increase.Estimate ball mould dosage by mixed powder weight, unnecessary ball mould adds purified water slurrying to be used as increase after crossing 40 mesh sieves, no Foot is supplied by above-mentioned molding method.Ball mould uniform in size is poured into coating pan, with above-mentioned mixed powder and clear cream or slurrying water Sieved when increasing to maximum repeatedly to diameter 5.75mm.Untill continuing to be enlarged to diameter 5.75mm less than 5.75mm, excessive ball Medicine adds purified water slurrying to make adhesive or as tailing.

3rd, dry

The general uniform stall with goods spread out on the ground for sale of good pill is entered in drip pan, thickness about 2~3cm, hot air circulation drying room is put into and is dried, is done Dry temperature control is between 60 DEG C~80 DEG C, and Steam pressure control is between 0.1~0.4Mpa.It should be turned in drying process Disk.Go out baking oven after pill drying, fine powder is weeded out after cooling and is loaded in clean bucket.Qualified pill is examined to bottle standby.

The preparation of the Chinese medicine composition decoction of embodiment 2

Prescription (parts by weight)：2.5 parts of the fleece-flower root (system), 1.5 parts of the Radix Astragali, even 1.5 parts of ink drought, 1 part of the fruit of glossy privet, Ramulus Taxilli 1.75 parts, 1.5 parts of the vine of multiflower knotweed, 1.5 parts of the Fen, Common St.Paulswort Herbs of reticulate millettia 2,2 parts of ilex pubescens, 2 parts of serissa serissoide, 1 part of grass-leaved sweetflag, fructus viticis 1 part, 1 part of psoralea corylifolia, 1.5 parts of the rhizome of davallia, 1 part of duckweed, 1 part of root tuber of aromatic turmeric, 1 part of cortex albiziae, 2 parts of mother-of-pearl.

The net medicinal material of said ratio is rinsed after being soaked more than 2 hours in container with water, after normal pressure decocts 20 minutes, filtered Go out decoction, obtain the decoction of Chinese medicine composition of the present invention.

The preparation of the Chinese medicinal composition granules of embodiment 3

Prescription (parts by weight)：2.5 parts of the fleece-flower root (system), 1.5 parts of the Radix Astragali, even 1.5 parts of ink drought, 1 part of the fruit of glossy privet, Ramulus Taxilli 1.75 parts, 1.5 parts of the vine of multiflower knotweed, 1.5 parts of the Fen, Common St.Paulswort Herbs of reticulate millettia 2,2 parts of ilex pubescens, 2 parts of serissa serissoide, 1 part of grass-leaved sweetflag, fructus viticis 1 part, 1 part of psoralea corylifolia, 1.5 parts of the rhizome of davallia, 1 part of duckweed, 1 part of root tuber of aromatic turmeric, 1 part of cortex albiziae, 2 parts of mother-of-pearl.

The net medicinal material of said ratio is rinsed after being soaked more than 2 hours in container with water, after normal pressure decocts 30 minutes, filtered Go out decoction, obtain the water extract of Chinese medicine composition of the present invention, dextrin is added after concentration, Icing Sugar, is mixed, with appropriate 70% ethanol system Softwood, No. 1 sieve series grain is crossed, 50 DEG C of drying 2 hours, dry particle crosses 12~14 mesh sieve whole grains, dispenses, produces.

The clinical statisticses of effect example 1

Case source：Case collected from January, 2010 between in December, 2016, with alopecia areata, whole alopecia, general alopecia and postpartum, disease Alopecia merges insomnia, stress etc. and gone to a doctor in Baoshan District, Shanghai Song Nan towns community medical service center alopecia traditional Chinese medicine spy afterwards The hair loss patient of color disease that calls for specialized treatment outpatient service.

Inclusive criteria：Patient meets Western medicine diagnostic criteria and TCM syndrome diagnostic criteria simultaneously.

Reference《Clinical dermatology》、《Modern Chinese medicine skin cypridology》、《Tcm clinical practice diagnosis and treatment term-syndrome part》、 《Dermatology ＆ STD Dept. disease that calls for specialized treatment tcm clinical practice diagnosis and treatment》、《Surgery of Chinese Medicine》、《Skin cypridology》、《Hair follicle disease》Etc. drafting.

1st, doctor trained in Western medicine standard

(1) suddenly or hair flaking in a short time, single-shot or multiple, or even hair all it is bald fall (whole alopecia), eyebrow, armpit Hair, pubes, beard and fine hair on birds or animals hair come off (general alopecia)；

(2) alopecia area color of the leather is normal, without obvious inflammatory reaction；

(3) alopecia area skin has no atrophy and scar.

2nd, traditional Chinese medical science standard

Withered and yellowish hairs or greyish white usually, hair uniformly comes off in piece during morbidity, even whole body hair is de- to the greatest extent, after being ill, postpartum Or prolonged illness alopecia, or have alopecia family history.Be often accompanied by the lazy speech of spiritlessness and weakness, shortness of breath, dizzy, soreness and weakness of waist and knees, it is nervous, Dream of being insomnia is more, pale tongue with thin fur or tongue nature is light red, arteries and veins is thin or thin and delicate.

3rd, clinical stages diagnostic criteria

(1) progressive stage：Alopecia area edge hair loosens, and is drawn out easily, and light draw tests (+), extraction hair, visible under microscope Hair shaft near-end atrophy, in " exclamation mark " sample, as number increases, infringement continues to expand, and can merge into each other into irregular patch；

(2) resting stage：Alopecia spot edge hair no longer loosens, without emerging focus, most of patients alopecia static 3 to 4 Enter convalescence after month；

(3) convalescence：There is newborn hair in alopecia area, the shallow fine hair of soft color, gradual thickening initially occur, color becomes It is deep, finally recover normal.

4th, criterion of therapeutical effect：

Recovery from illness：Hair loss area whole hair growth

It is effective：Alopecia area black or the new hair tonic of white account for 70%

Effectively：The fine hair on birds or animals hair growth of alopecia area accounts for more than 20%

It is invalid：Alopecia area grows without fine hair on birds or animals hair, or even expands

Observation of curative effect：To 120 patients included by above-mentioned standard, male totally 58 people, women totally 62 people, the age 12~60 One full year of life, the course of disease<2 years, bald spot >=3 piece, diameter >=3 centimetre, each 60 of 120 patients were respectively adopted in the embodiment of the present invention 1 and 2 Water pill (A groups) and decoction (B groups) treat, A groups 60 (285 bald spots), B groups 60 (314 bald spots),

A group medications：The general ball of traditional Chinese medicine composition water, 2 times a day, each 6g, morning, supper half an hour after are oral.

B group medications：Chinese medicine composition decoction, daily 1 dose, it is decocted in water for oral dose, about 500mL divides early, evening to take twice.

Drug treatment：30 days as one therapeutic course, continuously take 3 courses for the treatment of.

Having 15 patients (62 bald spots) to miss the target in 120 patients, (wherein A groups 6 are missed the target 23 bald spots, and B groups 9 are missed the target 39 bald spots), observation of curative effect record is done because failing further consultation on time, therefore do not include curative effect statistics.Complete 105 trouble of clinical observation Person is before medication, January, no abnormal in the hepatic and renal function follow-up investigations after March.Sex, age, the disease of two groups of patients Journey, severity extent comparing difference are not statistically significant (P ＞ 0.05).

After treatment in 3 months, the hair growth situation for being finally completed two groups of patients of clinical observation uses SPSS18.0 Software carries out statistical analysis, and as a result as shown in table 1, ranked data use rank test, and P=0.001 (＜ 0.05), group is interior, group Between it is variant, it is statistically significant.

The traditional Chinese medicine composition for treating patients with alopecia areata curative effect of table 1 compares (example (%))

As shown in Table 1, Chinese medicine composition of the invention can effectively treat alopecia areata, whole alopecia, general alopecia and postpartum, take off after being ill Hair, and merge the simultaneous phenomenons such as insomnia, stress, the A groups treated using the general ball of the traditional Chinese medicine composition water of the embodiment of the present invention 1 Total effective rate is up to 93.2%, and uses the B group total effective rates of the Chinese medicine composition decoction of the embodiment of the present invention 1 higher, reachable 96.7%, and two groups have no adverse reaction.

2 classical case of effect example

【Case by】

X, female, 44 years old, the first visit date:On March 13rd, 2015

The a large amount of alopecias of patient, disc-shaped increasingly increase 2 months without hair area.

【First visit】

The a large amount of alopecias of patient, disc-shaped increasingly increase 2 months without hair area, and shaped like the coin shape to differ in size, come off place's scalp Smooth color is white, no itch, smell without exception, and hair loosens around alopecia area, voluntarily attempts not show using ginger rubbing outside effect.Suffer from Usually hair dries up person, lustreless complexion, insomnia and dreamful sleep, and mood is irritable, and soreness and weakness of waist and knees, two is just unobstructed, the few tongue of pink tongue, and arteries and veins is thin.

【Pathogenic analysis】

Blood stored in the liver, send out as more than blood, anemia is sent out withered.Kidney person, the congenital foundation, the source of essence and blood, its Hua Fa.Kidney deficiency and liver, essence Do not change blood, blood not hair care, the flesh natural fibre line of meat loses profit, and the long weary source of hair, hair root is hollow, deals with flakes.Asthenia of essence and blood, the mind, which is lost, supports, and liver depression is not Relax, therefore insomnia and dreamful sleep, mood are irritable；Caused by liver and kidney deficiency, muscles and bones, which is lost, supports, therefore soreness and weakness of waist and knees, spiritlessness and weakness；Essence and blood can not go up it is flourish in Face, therefore lustreless complexion；Pale tongue with thin fur is white, and arteries and veins is thin, be also asthenia of essence and blood as.

【Diagnosis】The traditional Chinese medical science：Alopecia areata disease；Doctor trained in Western medicine：Alopecia areata

【Differentiation of symptoms and signs for classification of syndrome】Deficiency of kidney-QI, liver depression are not relaxed, asthenia of essence and blood

【The rules for the treatment of】Tonifying Qi kidney-nourishing, soothing liver-qi stagnation, blood nourishing and hair

【By controlling】The Chinese medicine composition decoction of present example 2, is decocted in water for oral dose by daily 1 dose, and about 500mL divides early, evening to take twice With 30 days as one therapeutic course, continuously taking 3 courses for the treatment of.

【Diagnosis records】

11 days two April in 2015 examines：The soreness of waist is weak still to be had, and sleep is slightly stable, the few tongue of pink tongue, and arteries and veins is thin.Check liver kidney function Energy no abnormality seen, externally used compound safflower tincture have no adverse reaction.Alopecia area has no new hair tonic, alopecia area periphery hair pull out not See loosening.Continue former method opinion to control.

10 days three May in 2015 examines：Patient feels that spiritlessness and weakness, soreness and weakness of waist and knees substantially mitigate, and original fine hair on birds or animals hair adds at alopecia Close color palm fibre.Pink tongue tongue is thin, and arteries and veins is thin.Hepatic and renal function no abnormality seen is checked, former method is treated and advises it to shave off fine hair on birds or animals hair at alopecia.

The four methods of diagnosis on June 12 in 2015：Patient mental is good, receives the peace that can sleep, and two is just smooth, alopecia area new life dark hair into it is luxuriant it Gesture, pink tongue tongue is thin, and arteries and veins is thin.It is without exception to check hepatic and renal function.Clinical cure.

General principle, principal character and the advantages of the present invention of the present invention has been shown and described above.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the simply explanation described in above-described embodiment and specification is originally The principle of invention, various changes and modifications of the present invention are possible without departing from the spirit and scope of the present invention, these changes Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its Equivalent defines.

Claims (8)

1. a kind of treat alopecia areata, whole alopecia, general alopecia and postpartum, post disease alopecia merging insomnia, nervous Chinese medicine composition, it is special Sign is that it includes the bulk drug of following parts by weight：The non-irrigated company 1.2 of 2.2~2.8 parts of the fleece-flower root, 1.2~1.8 parts of the Radix Astragali, ink~ 1.8 parts, 0.8~1.2 part of the fruit of glossy privet, 1.5~2 parts of Ramulus Taxilli, 1.2~1.8 parts of the vine of multiflower knotweed, the Fen, pig Xian of reticulate millettia 1.8~2.2 1.2~1.8 parts of grass, 1.8~2.2 parts of ilex pubescens, 1.8~2.2 parts of serissa serissoide, 0.8~1.2 part of grass-leaved sweetflag, fructus viticis 0.8~ 1.2 parts, 0.8~1.2 part of psoralea corylifolia, 1.2~1.8 parts of the rhizome of davallia, 0.8~1.2 part of duckweed, 0.8~1.2 part of root tuber of aromatic turmeric, cortex albiziae 0.8~1.2 part, 1.8~2.2 parts of mother-of-pearl.

2. Chinese medicine composition as claimed in claim 1, it is characterised in that the fleece-flower root is 2.5 parts, the Radix Astragali is 1.5 parts, ink drought connects For 1.5 parts, the fruit of glossy privet be 1 part, Ramulus Taxilli is 1.75 parts, the vine of multiflower knotweed is 1.5 parts, reticulate millettia is that 2 Fen, Common St.Paulswort Herbs are 1.5 part, maos Chinese ilex is 2 parts, serissa serissoide is 2 parts, grass-leaved sweetflag is 1 part, fructus viticis is 1 part, psoralea corylifolia is 1 part, the rhizome of davallia is 1.5 parts, duckweed For 1 part, root tuber of aromatic turmeric be 1 part, cortex albiziae is 1 part, mother-of-pearl is 2 parts.

3. a kind of Chinese medicine composition using described in claim 1 or 2 is used as the pharmaceutical preparation of active ingredient.

4. pharmaceutical preparation as claimed in claim 3, it is characterised in that its be decoction, water pill, granule, electuary, powder or Glue oral liquid.

5. the preparation method of pharmaceutical preparation as claimed in claim 3, it is characterised in that including step：By each raw material of prescription After medicine mixing, decoction is carried out 0.3~2.5 hour using 5~10 times of amount water, Steam pressure control is 0.02MPa~0.15MPa, Decoction can be filtered out after decoction.

6. method as claimed in claim 5, it is characterised in that using 7~10 times of amount water during decoction, decoct 1.5~2.5 hours The decoction filtered out afterwards is head juice；Add 4~8 times of amount water and carry out secondary decoction, the decoction filtered out after 1.5~2.5 hours is two Juice；After merging head juice and two juice then filtering and concentrating obtains to the clear cream that relative density is 1.08~1.12 after general ball, drying Water pill.

7. method as claimed in claim 6, it is characterised in that during each bulk drug mixing, in advance by the fleece-flower root, the fruit of glossy privet, bone It is broken to mend, be ground into fine powder after duckweed mixing and cross 100 mesh sieves and obtain mixed powder；Mixed powder and clear cream molding are used during general ball.

8. method as claimed in claim 5, it is characterised in that each bulk drug is rinsed with water and soaked 2~4 hours before decocting, After normal pressure decocts 20~40 minutes, decoction is filtered out, dextrin and Icing Sugar are added after concentration, with 70% ethanol softwood after mixing, crosses No. 1 Sieve series grain, 40~60 DEG C are dried to obtain granule.