CN104623503A - Traditional Chinese medicine preparation for treating hyperthyreosis and preparation process thereof - Google Patents
Traditional Chinese medicine preparation for treating hyperthyreosis and preparation process thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating hyperthyreosis and a preparation process thereof. The traditional Chinese medicine preparation is prepared from the following main medicinal raw materials in parts by weight: 10-20 parts of fructus amomi, 8-15 parts of eucommia ulmoides, 6-9 parts of herba fibraureae recisae, 5-10 parts of jews marro, 10-15 parts of raspberry, 10-20 parts of fermented soybean, 5-10 parts of fried nux prinsepiae, 15-20 parts of fried spina date seed, 9-16 parts of raw semen cuscutae, 8-12 parts of rhizoma pinelliae preparata, 8-12 parts of fritillary bulb, 8-12 parts of seaweed, 5-10 parts of raw oyster, 10-20 parts of angelica, 10-20 parts of yam, 9-16 parts of pericarpium citri reticulatae, 8-12 parts of safflower, 7-15 parts of dogwood, 10-20 parts of radix trichosanthis and 15-20 parts of semen boitae. The traditional Chinese medicine preparation disclosed by the invention is safe and effective, free of adverse reactions, and capable of avoiding recurrence, effectively eliminating or relieving clinical symptoms of hyperthyroidism and conditioning integral organism function.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine and the preparation technology thereof that treat hyperthyroidism.
Background technology
Hyperthyroidism (being called for short " hyperthyroidism ") is because the too much caused common endocrinopathy of one of thyroid hormone secretion.It is generally acknowledged that hyperthyroidism is a kind of autoimmune disease.The stress state such as direct stimulation, infection is the common inducement of primary disease, and Inheritance also has certain relation.Clinical based on thyromegaly, bulimia, lose weight, tachycardia, emotion are easy to exciting, To Be Protected from Heat symptoms such as hyperhidrosis, hand shaking, expophthalmos.Hyperthyroidism one is sick, very similar with " melancholy wart ", " goiter due to disorder of QI " in traditional Chinese medical science goiter.Sui Dynasty " General Treatise on the Cause and Symptoms of Diseases " points out: " wart person, melancholy Gui depressed give birth to, also drink husky water day, Sha Suiqi forms it under entering pulse neck." illustrate wart generation relevant with water and soil factor to feelings will internal injury.The Tang Dynasty Sun Simiao describes the square medicine and moxibustion therapy of controlling goiter in Prescriptions Worth Thousand Gold for Emergencies.The hyperthyroidism cause of disease mainly feelings will internal injury, physical factors, diet and water and soil is inappropriate.And stagnation of QI due to depression of the liver, QI-blood circulation is not normal, and phlegm-damp condenses, and stopping up knot throat is hyperthyroidism basic pathogenesis.Hyperthyroidism is from the beginning of how real, and how empty prolonged illness is.Expectorant: drinking and eating irregularly or because of water and soil inappropriate, affect transformation and transportation of the spleen and stomach, dysfunction of the spleen in transportation, accumulatively wet raise phlegm, multiple because of depression of liver-QI, QI-blood circulation is smooth, and expectorant, with depressed, stops up that to form wart in throat swollen.Evil: long-term angry strongly fragrant angry, feelings will is not relaxed, and causes stagnation of QI due to depression of the liver, and body fluid is not transported for it, is condensed into expectorant, mental disorder is handed over resistance and gradually becomes hyperthyroidism.If the stagnation of QI is with the passing of time, or patient's ferritic deficiency of YIN, be easy to the gesture that fire-transformation forms overabundant liver-fire; If expectorant knot with the passing of time, QI-blood circulation is not normal, causes qi depression to blood stasis, wart can be made to swell hard.Empty: overabundant liver-fire, burn bright Liver Channel, consumption impairment of YIN blood, the feature such as women's warp, band, tire, product, breast also easily causes deficiency of YIN-blood in addition, becomes the body of hyperactivity of fire caused by deficiency of YIN; Again because of " hyperactive fire wasting QI ", hyperactivity of fire is with the passing of time then felt frustrated, and causes the card of deficiency of both QI and YIN.Above etiology and pathogenesis connects each other often.
Treatment of Hyperthyroidism has three kinds of methods, Anti-thyroid Medicine, radioiodine therapy and operative treatments.Anti-thyroid Medicine wide accommodation, no matter child adult, male or women, mild or serious symptom hyperthyroidism, First episode or hyperthyroidism recurrence, anemia of pregnant woman or lactating female hyperthyroidism can use Drug therapy.Antithyroid drug has two kinds---and imidazoles and thiouracil class, represent medicine and be respectively thiamazole (also known as " thiamazole ") and propylthiouracil (also known as " third is phonetic ").Drug therapy is applicable to the patient of Hyperthyroidism Mothers, child, thyroid silght enlargement, and treatment is general needs 1 ~ 2 year, needs according to thyroid function situation increase and decrease drug dose in treatment.Drug therapy has some side effect, comprise granulocytopenia, drug allergy, liver function damage, arthralgia and vasculitis, the Drug therapy initial stage needs tightly to monitor side effects of pharmaceutical drugs, especially agranulocytosis, need to warn patient once there is heating and/or pharyngalgia, need to check granulocyte immediately clearly whether there is agranulocytosis, once occur.Drug withdrawal emergency treatment immediately.Another shortcoming of Drug therapy is that after drug withdrawal, relapse rate is high, greatly about about 50%.Radioiodine is applicable to the patient of thyroid moderate swelling or hyperthyroidism recurrence, and doctor calculates the radiological dose of each needs of patients according to the uptake ratio of patient's thyroid to radioiodine.Radioiodine is absolute contraindication to anemia of pregnant woman and nursing women.Effect due to radioiodine has a delay action, along with the time is with examining, and hyperthyroidism incidence rate annual 3% ~ 5%.Radioiodine therapy is not suitable for the hyperthyroid patient of thyroid eye diseas, because oculopathy may be aggravated after treatment.That operative treatment is applicable to those thyromegaly is remarkable, or strong suspicion thyroid malignancy, or thyromegaly has the tracheas suppressed person that causes dyspnea.Operation consent needs to control in normal range with medicine by thyroid function, and the preoperative oral administered compound iodine solution that also needs does Preoperative Method.
Application publication number CN 103505666 A(application number 201210199841.0) Chinese patent literature disclose a kind of Chinese medicine for the treatment of hyperthyroidism, described formula forms by following weight: Sargassum 28-32 gram, Thallus Laminariae (Thallus Eckloniae) 28-32 gram, Spica Prunellae 28-32 gram, Bulbus Fritillariae Thunbergii 18-22 gram, Rhizoma Sparganii 13-17 gram, Pericarpium Citri Reticulatae Viride 13-17 gram, Rhizoma Atractylodis Macrocephalae 18-22 gram, Herba Dendrobii 18-22 gram, Rhizoma Dioscoreae 18-22 gram, Radix Pseudostellariae 18-22 gram, Radix Rehmanniae Preparata 18-22 gram, Semen Sinapis Albae 10-14 gram.Application publication number CN 104013798 A(application number 201410281563.2) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of hyperthyroidism, the raw material of described medicine comprises Thallus Laminariae (Thallus Eckloniae), Pericarpium Citri Reticulatae, Rhizoma Coptidis, Fructus Tribuli, Radix Paeoniae Alba, Radix Glycyrrhizae, Radix Sophorae Flavescentis, Radix Ophiopogonis, Fructus Forsythiae, Caulis Polygoni Multiflori, the Radix Aucklandiae ten a herb.Application publication number CN 101897927 A(application number 201010219145.2) Chinese patent literature disclose a kind of pharmaceutical composition preventing and treating hyperthyroidism, this pharmaceutical composition is made up of active component and pharmaceutically acceptable adjuvant, described active component is made up of the crude drug of following percentage by weight: Spica Prunellae 5 ~ 25, Thallus Laminariae (Thallus Eckloniae) 5 ~ 25%, Fructus Forsythiae 15 ~ 30%, Bulbus Fritillariae Thunbergii 10 ~ 40%, Concha Ostreae 15 ~ 40%, Rhizoma Cyperi 5 ~ 25%, Radix Curcumae 5 ~ 25%, Pericarpium Citri Reticulatae 5 ~ 20%.
At present, Modern medical therapy hyperthyroidism mainly contains three kinds of method, i.e. Anti-thyroid Medicine, radioiodine therapy and operative treatments.But erious adverse reaction, patient can not tolerate.Western medicine also exists many untoward reaction, and relapse rate is high, and operation and radioiodine therapy may cause lifelong hypothyroidism.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine and the preparation technology thereof that treat hyperthyroidism.The present invention is safe and effective, has no adverse reaction, and not easily recurs, and effectively can eliminate or improve hyperthyroidism clinical symptoms, conditioning human body allomeric function.
Technical scheme of the present invention is:
The Chinese medicine for the treatment of hyperthyroidism, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Amomi 10-20, Cortex Eucommiae 8-15, Caulis Fibraureae 6-9, Flos kerriae japonicae 5-10, Fructus Rubi 10-15, Semen Sojae Preparatum 10-20, fry Nux Prinsepiae 5-10, Semen Ziziphi Spinosae (parched) 15-20, raw Semen Cuscutae 9-16, Rhizoma Pinelliae 8-12, Bulbus Fritillariae Thunbergii 8-12, Sargassum 8-12, Concha Ostreae 5-10, Radix Angelicae Sinensis 10-20, Rhizoma Dioscoreae 10-20, Pericarpium Citri Reticulatae 9-16, Flos Carthami 8-12, Fructus Corni 7-15, Radix Trichosanthis 10-20, Semen Platycladi 15-20.
The Chinese medicine for the treatment of hyperthyroidism, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Amomi 14-18, Cortex Eucommiae 10-13, Caulis Fibraureae 7-8.5, Flos kerriae japonicae 6-8, Fructus Rubi 11-14, Semen Sojae Preparatum 13-16, fry Nux Prinsepiae 6-8, Semen Ziziphi Spinosae (parched) 16-18, raw Semen Cuscutae 11-14, Rhizoma Pinelliae 9-11, Bulbus Fritillariae Thunbergii 9-11, Sargassum 9-11, Concha Ostreae 6.5-8, Radix Angelicae Sinensis 15-18, Rhizoma Dioscoreae 14-17, Pericarpium Citri Reticulatae 12-15, Flos Carthami 9-11, Fructus Corni 9-13, Radix Trichosanthis 12-17, Semen Platycladi 16-18.
The Chinese medicine for the treatment of hyperthyroidism, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Fructus Amomi 16, the Cortex Eucommiae 11, Caulis Fibraureae 7.5, Flos kerriae japonicae 7, Fructus Rubi 12, Semen Sojae Preparatum 14, fry Nux Prinsepiae 7, Semen Ziziphi Spinosae (parched) 17, raw Semen Cuscutae 12, Rhizoma Pinelliae 10, Bulbus Fritillariae Thunbergii 10, Sargassum 10, Concha Ostreae 7, Radix Angelicae Sinensis 16, Rhizoma Dioscoreae 15, Pericarpium Citri Reticulatae 14, Flos Carthami 10, Fructus Corni 11, Radix Trichosanthis 14, Semen Platycladi 17.
Present invention also offers the preparation method Chinese medicine of aforementioned therapies hyperthyroidism being made pharmaceutically acceptable pill, thick paste agent, granule and tablet.
The preparation method of described pill is:
(1) refined honey is got, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is the weight of the preferred refined honey of 1/4-1/2(of Bulbus Fritillariae Thunbergii weight is 1/3 of Bulbus Fritillariae Thunbergii weight), after moistening 1.5-3 hour (preferred moistening is after 2.5 hours), put in hot pot, heat with slow fire, fry to time tack-free, take out, cool, be ground into fine powder, cross No. five sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 18-32 hour (preferably Semen Platycladi 50 degree of rice wine being soaked 28 hours), the consumption of rice wine is 2.5-3.5 times (consumption of preferred rice wine is 3 times of Semen Platycladi weight) of Semen Platycladi weight, Semen Platycladi after soaking is leached, dry, be ground into fine powder, cross No. five sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, with the general ball of step (2) gained filtrate, make the pill (preferably making every ball weight is the pill of 0.2g) that every ball weight is 0.15-0.25g, adopt fluid bed airpillow-dry, temperature controls at 55-60 DEG C, and by the water content control of pill below 6%.
The preparation method of described thick paste agent is:
(1) refined honey is got, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is the weight of the preferred refined honey of 1/4-1/2(of Bulbus Fritillariae Thunbergii weight is 1/3 of Bulbus Fritillariae Thunbergii weight), after moistening 1.5-3 hour (preferred moistening is after 2.5 hours), put in hot pot, heat with slow fire, fry to time tack-free, take out, cool, be ground into fine powder, cross No. six sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 18-32 hour (preferably Semen Platycladi 50 degree of rice wine being soaked 28 hours), the consumption of rice wine is 2.5-3.5 times (consumption of preferred rice wine is 3 times of Semen Platycladi weight) of Semen Platycladi weight, Semen Platycladi after soaking is leached, dry, be ground into fine powder, cross No. six sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are put into marmite, decoct with water twice, amount of water is the 3.7-5.4 of 18 taste crude drug gross weights doubly (preferred amount of water is 4.5 times of 18 taste crude drug gross weights), first boil with high heat to boiling, after turn slow fire boiling 1.3-1.6 hour (preferably then turn slow fire boiling 1.5 hours), merge medicinal liquid, filter;
(4) step (2) gained filtrate and step (3) gained medicinal liquid are merged, be concentrated into the clear paste (being preferably concentrated into the clear paste of relative density 1.25) of relative density 1.23-1.27, add refined honey, every 100kg clear paste adds the preferred every 100kg clear paste of refined honey 155-175kg(and adds refined honey 160kg), finally add step (1) and step (2) gained fine powder is mixed well, be divided in the container of clean dried sterilizing, covered and enclosed after fully cooling.
The preparation method of described granule is:
(1) refined honey is got, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is the weight of the preferred refined honey of 1/4-1/2(of Bulbus Fritillariae Thunbergii weight is 1/3 of Bulbus Fritillariae Thunbergii weight), after moistening 1.5-3 hour (preferred moistening is after 2.5 hours), put in hot pot, heat with slow fire, fry to time tack-free, take out, cool, be ground into fine powder, cross No. five sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 18-32 hour (preferably Semen Platycladi 50 degree of rice wine being soaked 28 hours), the consumption of rice wine is 2.5-3.5 times (consumption of preferred rice wine is 3 times of Semen Platycladi weight) of Semen Platycladi weight, Semen Platycladi after soaking is leached, dry, be ground into fine powder, cross No. five sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, then make altogether with 15% starch slurry and step (2) gained filtrate, the weight of starch is 1.0-1.3 times (weight of preferred starch is 1.2 times of gained fine powder gross weight) of gained fine powder gross weight;
(5) by step (4) fashion of extrusion that is able to by 16-20 eye mesh screen (preferably by step (4) fashion of extrusion that is able to logical 18 eye mesh screens), make uniform granule;
(6) step (5) gained granule is adopted fluid bed airpillow-dry, temperature controls at 60-65 DEG C, the water content control of granule within 2%, granulate subpackage and get final product.
The preparation method of described tablet is:
(1) refined honey is got, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is the weight of the preferred refined honey of 1/4-1/2(of Bulbus Fritillariae Thunbergii weight is 1/3 of Bulbus Fritillariae Thunbergii weight), after moistening 1.5-3 hour (preferred moistening is after 2.5 hours), put in hot pot, heat with slow fire, fry to time tack-free, take out, cool, be ground into fine powder, cross No. five sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 18-32 hour (preferably Semen Platycladi 50 degree of rice wine being soaked 28 hours), the consumption of rice wine is 2.5-3.5 times (consumption of preferred rice wine is 3 times of Semen Platycladi weight) of Semen Platycladi weight, Semen Platycladi after soaking is leached, dry, be ground into fine powder, cross No. five sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, then make altogether with 15% starch slurry, the weight of starch is 1.0-1.3 times (weight of preferred starch is 1.2 times of gained fine powder gross weight) of gained fine powder gross weight;
(5) by step (4) fashion of extrusion that is able to by 16-20 eye mesh screen (preferably by step (4) fashion of extrusion that is able to by 18 eye mesh screens), make uniform granule;
(6) step (5) gained granule is adopted fluid bed airpillow-dry, temperature controls at 60-65 DEG C, and the water content control of granule, within 2%, adds step (2) gained filtrate, mixing, tabletting, and the heavy 0.2g of every sheet, to obtain final product.
The Chinese medicine for the treatment of hyperthyroidism provided by the invention is with traditional Chinese medical science traditional theory for instructing, and scientific formula is reasonable.In addition, excellent results of the present invention also shows:
1, safe and effective, have no adverse reaction;
2, treating both the principal and secondary aspects of a disease, not easily recurs;
3, effectively can eliminate or improve hyperthyroidism clinical symptoms, conditioning human body allomeric function;
4, medicine source is easy to get;
5, all medicines share, and play the strongly fragrant relieving restlessness of a surname, nourishing the liver and kidney, drying dampness to eliminate phlegm, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, work of enriching blood altogether
Effect of blood, regulating qi-flowing for strengthening spleen, tranquilizing by nourishing the heart, amounts to strengthening vital QI to eliminate pathogenic factors, the merit for the treatment of both the principal and the secondary aspects of a disease at the same time.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the Chinese medicine for the treatment of hyperthyroidism, the primary raw material medicine getting following weight parts is prepared from (every part is 85g): Fructus Amomi 10 parts, the Cortex Eucommiae 8 parts, Caulis Fibraureae 6 parts, Flos kerriae japonicae 5 parts, Fructus Rubi 10 parts, Semen Sojae Preparatum 10 parts, fries Nux Prinsepiae 5 parts, Semen Ziziphi Spinosae (parched) 15 parts, raw Semen Cuscutae 9 parts, Rhizoma Pinelliae 8 parts, Bulbus Fritillariae Thunbergii 8 parts, Sargassum 8 parts, Concha Ostreae 5 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Dioscoreae 10 parts, Pericarpium Citri Reticulatae 9 parts, 8 parts, Flos Carthami, Fructus Corni 7 parts, Radix Trichosanthis 10 parts, Semen Platycladi 15.
The preparation method of the Chinese medicine granule of above-mentioned treatment hyperthyroidism is:
(1) get refined honey, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is 1/4 of Bulbus Fritillariae Thunbergii weight, and moistening, after 1.5 hours, is put in hot pot, with slow fire heating, fries to time tack-free, takes out, cool, be ground into fine powder, cross No. five sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 18 hours, the consumption of rice wine is 2.5 times of Semen Platycladi weight, and leached by the Semen Platycladi after soaking, dry, be ground into fine powder, cross No. five sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, then make altogether with 15% starch slurry and step (2) gained filtrate, the weight of starch is 1.0 times of gained fine powder gross weight;
(5) by step (4) fashion of extrusion that is able to by 16 eye mesh screens, make uniform granule;
(6) step (5) gained granule is adopted fluid bed airpillow-dry, temperature controls at 60-65 DEG C, the water content control of granule within 2%, granulate subpackage and get final product.
The using method that the present invention treats the Chinese medicine granule of hyperthyroidism is: boiled water is taken after mixing it with water, every day three times, each 5g.
embodiment 2the Chinese medicine for the treatment of hyperthyroidism, the primary raw material medicine getting following weight parts is prepared from (every part is 85g): Fructus Amomi 20 parts, the Cortex Eucommiae 15 parts, Caulis Fibraureae 9 parts, Flos kerriae japonicae 10 parts, Fructus Rubi 15 parts, Semen Sojae Preparatum 20 parts, fries Nux Prinsepiae 10 parts, Semen Ziziphi Spinosae (parched) 20 parts, raw Semen Cuscutae 16 parts, Rhizoma Pinelliae 12 parts, Bulbus Fritillariae Thunbergii 12 parts, Sargassum 12 parts, Concha Ostreae 10 parts, Radix Angelicae Sinensis 20 parts, Rhizoma Dioscoreae 20 parts, Pericarpium Citri Reticulatae 16 parts, 12 parts, Flos Carthami, Fructus Corni 15 parts, Radix Trichosanthis 20 parts, Semen Platycladi 20.
The preparation method of the Chinese medicine pill of above-mentioned treatment hyperthyroidism is:
(1) get refined honey, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is 1/3 of Bulbus Fritillariae Thunbergii weight, and moistening, after 2.5 hours, is put in hot pot, with slow fire heating, fries to time tack-free, takes out, cool, be ground into fine powder, cross No. five sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 28 hours, the consumption of rice wine is 3 times of Semen Platycladi weight, and leached by the Semen Platycladi after soaking, dry, be ground into fine powder, cross No. five sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, with the general ball of step (2) gained filtrate, making every ball weight is the pill of 0.2g, adopts fluid bed airpillow-dry, temperature controls at 55-60 DEG C, and by the water content control of pill below 6%.
model case one:sieve XX, female, 38 years old.Main suit: cardiopalmus, hyperhidrosis 4 years, increases the weight of 3 months.There is cardiopalmus, hyperhidrosis without obvious inducement before 4 years in patient, does not pay attention to, and within nearly three months, above-mentioned symptom increases the weight of gradually, companion's insomnia, discomfort of neck area, anxious state of mind, body weight Progressive symmetric erythrokeratodermia declines about 4kg, once accepted anti-inflammatory treatment at local hospital, and had no and be clearly better, and then came to go to a doctor.Look into thyroid function five, FT3:11.52pg/mL, FT4:4.18ng/dL, TSH:0.025uTU/mL, T3:3.84nmol/L, T4:22.42ug/dL.Thyroid color ultrasound is shown: bilateral thyroid volume is bigger, interior diffuse lesion, and in thyroid, blood flow signal enriches.Routine blood test: leukocyte 3.8 × 10
9/ L, neutrophilic granulocyte percentage ratio 40.5%.Be diagnosed as hyperthyroidism.Take the Chinese medicine pill of the present embodiment gained treatment hyperthyroidism, every day three times, each 6 balls, warm water delivery service.Take 2 weeks, the symptom such as cardiopalmus, hyperhidrosis is comparatively before clearly better.Continue to take 2 weeks, all disease knowing disappear, and check thyroid function recovers normal.Follow up a case by regular visits to and do not recur.
embodiment 3the Chinese medicine for the treatment of hyperthyroidism, the primary raw material medicine getting following weight parts is prepared from (every part is 85g): Fructus Amomi 14 parts, the Cortex Eucommiae 10 parts, Caulis Fibraureae 7 parts, Flos kerriae japonicae 6 parts, Fructus Rubi 11 parts, Semen Sojae Preparatum 13 parts, fries Nux Prinsepiae 6 parts, Semen Ziziphi Spinosae (parched) 16 parts, raw Semen Cuscutae 11 parts, Rhizoma Pinelliae 9 parts, Bulbus Fritillariae Thunbergii 9 parts, Sargassum 9 parts, Concha Ostreae 6.5 parts, Radix Angelicae Sinensis 15 parts, Rhizoma Dioscoreae 14 parts, Pericarpium Citri Reticulatae 12 parts, 9 parts, Flos Carthami, Fructus Corni 9 parts, Radix Trichosanthis 12 parts, Semen Platycladi 16.
The preparation method of the Chinese medicine thick paste agent of above-mentioned treatment hyperthyroidism is:
(1) get refined honey, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is 1/3 of Bulbus Fritillariae Thunbergii weight, and moistening, after 2.5 hours, is put in hot pot, with slow fire heating, fries to time tack-free, takes out, cool, be ground into fine powder, cross No. six sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 28 hours, the consumption of rice wine is 3 times of Semen Platycladi weight, and leached by the Semen Platycladi after soaking, dry, be ground into fine powder, cross No. six sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are put into marmite, decoct with water twice, amount of water is 4.5 times of 18 taste crude drug gross weights, first boils with high heat to boiling, after turn slow fire boiling 1.5 hours, merge medicinal liquid, filter;
(4) step (2) gained filtrate and step (3) gained medicinal liquid are merged, be concentrated into the clear paste of relative density 1.25, add refined honey, every 100kg clear paste adds refined honey 160kg, finally add step (1) and step (2) gained fine powder is mixed well, be divided in the container of clean dried sterilizing, covered and enclosed after fully cooling.
model case two:king XX, female, 34 years old.Main suit: irritated, insomnia, hyperhidrosis, weak, xerostomia more than 2 years.Be diagnosed as hyperthyroidism on inspection at local hospital, long-term taking thiamazole, curative effect is not obvious, comes to go to a doctor.Examine and see that patient is except above-mentioned symptom, patient's red tongue, yellow fur is few, stringy and thready pulse and counting.Be diagnosed as hyperthyroidism.Take the Chinese medicine thick paste agent of the present embodiment gained treatment hyperthyroidism, every day three times, each 4g, warm boiled water.After taking 10 days, symptom is improved.Continue to take three weeks, above-mentioned symptom disappears, and check thyroid function recovers normal.Follow up a case by regular visits to and do not recur.
embodiment 4the Chinese medicine for the treatment of hyperthyroidism, the primary raw material medicine getting following weight parts is prepared from (every part is 85g): Fructus Amomi 18 parts, the Cortex Eucommiae 13 parts, Caulis Fibraureae 8.5 parts, Flos kerriae japonicae 8 parts, Fructus Rubi 14 parts, Semen Sojae Preparatum 16 parts, fries Nux Prinsepiae 8 parts, Semen Ziziphi Spinosae (parched) 18 parts, raw Semen Cuscutae 14 parts, Rhizoma Pinelliae 11 parts, Bulbus Fritillariae Thunbergii 11 parts, Sargassum 11 parts, Concha Ostreae 8 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Dioscoreae 17 parts, Pericarpium Citri Reticulatae 15 parts, 11 parts, Flos Carthami, Fructus Corni 13 parts, Radix Trichosanthis 17 parts, Semen Platycladi 18.
The preparation method of the Chinese medicine tablet of above-mentioned treatment hyperthyroidism is:
(1) get refined honey, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is 1/3 of Bulbus Fritillariae Thunbergii weight, and moistening, after 2.5 hours, is put in hot pot, with slow fire heating, fries to time tack-free, takes out, cool, be ground into fine powder, cross No. five sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 28 hours, the consumption of rice wine is 3 times of Semen Platycladi weight, and leached by the Semen Platycladi after soaking, dry, be ground into fine powder, cross No. five sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, then make altogether with 15% starch slurry, the weight of starch is 1.2 times of gained fine powder gross weight;
(5) by step (4) fashion of extrusion that is able to by 18 eye mesh screens, make uniform granule;
(6) step (5) gained granule is adopted fluid bed airpillow-dry, temperature controls at 60-65 DEG C, and the water content control of granule, within 2%, adds step (2) gained filtrate, mixing, tabletting, and the heavy 0.2g of every sheet, to obtain final product.
model case three:cui XX, man, 40 years old.Main suit: feed increases, hyperhidrosis, cardiopalmus seven months, double eyeball gives prominence to two weeks.Patient is easily hungry without obvious inducement before seven months, and feed increases, simultaneously with hyperhidrosis, and cardiopalmus, irritated symptom.Normal at local hospital chemical examination blood glucose, to tranquilizer treatment without taking a turn for the better.Nearly two weeks comes, and patient's double eyeball is given prominence to, normal depending on thing, comes to go to a doctor.Lose weight after disease 6kg.Have a medical check-up: T 37.2 DEG C, P 110 beats/min, R 22 beats/min, BP130/60mmHg.Grow normal, become thin, moist skin, superficial lymph knot is without enlargement, and double eyeball is given prominence to, and closed obstacle, lolled and carefully quivered, thyroid II degree of enlargement, matter is soft, and on two, pole can be touched and tremble, audible and vascular murmur.Lung (-), percussion heart circle is little, heart rate 110 beats/min, and rule is neat.Two lower limb pneumonedema, has stretched out one's hand and has carefully quivered.Lab testing: Hb 122g/L, WBC 6.8 × 10
9/ L, N 65%, L 3,5%, PLT 240 × 10
9/ L; Routine urinalysis (-), stool for routine (-).Be diagnosed as hyperthyroidism.Take the Chinese medicine tablet of the present embodiment gained treatment hyperthyroidism, every day three times, each 3, temperature is opened and is taken.After taking 1 week, symptom makes moderate progress.Continue to take two weeks, above-mentioned symptom disappears, and check thyroid function recovers normal.Follow up a case by regular visits to and do not recur.
embodiment 5the Chinese medicine for the treatment of hyperthyroidism, the primary raw material medicine getting following weight parts is prepared from (every part is 85g): Fructus Amomi 16, the Cortex Eucommiae 11, Caulis Fibraureae 7.5, Flos kerriae japonicae 7, Fructus Rubi 12, Semen Sojae Preparatum 14, fries Nux Prinsepiae 7, Semen Ziziphi Spinosae (parched) 17, raw Semen Cuscutae 12, Rhizoma Pinelliae 10, Bulbus Fritillariae Thunbergii 10, Sargassum 10, Concha Ostreae 7, Radix Angelicae Sinensis 16, Rhizoma Dioscoreae 15, Pericarpium Citri Reticulatae 14, Flos Carthami 10, Fructus Corni 11, Radix Trichosanthis 14, Semen Platycladi 17.
The preparation method of the Chinese medicine granule of above-mentioned treatment hyperthyroidism is:
(1) get refined honey, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is 1/3 of Bulbus Fritillariae Thunbergii weight, and moistening, after 2.5 hours, is put in hot pot, with slow fire heating, fries to time tack-free, takes out, cool, be ground into fine powder, cross No. five sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 28 hours, the consumption of rice wine is 3 times of Semen Platycladi weight, and leached by the Semen Platycladi after soaking, dry, be ground into fine powder, cross No. five sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, then make altogether with 15% starch slurry and step (2) gained filtrate, the weight of starch is 1.2 times of gained fine powder gross weight;
(5) by step (4) fashion of extrusion that is able to by 18 eye mesh screens, make uniform granule;
(6) step (5) gained granule is adopted fluid bed airpillow-dry, temperature controls at 60-65 DEG C, the water content control of granule within 2%, granulate subpackage and get final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Amomi: another name: the husky honey of contracting, contracting Fructus Amomi, Amomum xanthioides are mature fruit or the seed of zingiberaceous plant Fructus Amomi, green shell sand Renhe Fructus Amomi.The property of medicine: acrid in the mouth, warm in nature.Return spleen, stomach, kidney channel.Function cures mainly: removing dampness is whetted the appetite, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, warming spleen and stopping diarrha, antiabortive.Main retention of damp leading to blockage of QI, distension and fullness in the abdomen, anorexia, nausea and vomiting, pregnancy reactions of having loose bowels of suffering from abdominal pain, frequent fetal movement.
The Cortex Eucommiae: base is former: be the dry bark of the Eucommiaceae plant Cortex Eucommiae.The property of medicine: sweet, temperature.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement, hypertension.
Caulis Fibraureae: base is former: be rhizome or the leaf of menispermaceous plants Caulis Fibraureae.The property of medicine: bitter, cold in nature.GUIXIN, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, dampness removing.Main acute tonsillitis, pharyngolaryngitis, upper respiratory tract infection, conjunctivitis, jaundice, gastroenteritis, dysentery, infantile dyspepsia, food poisoning, salpingitis, acute and chronic endometritis, acute pelvic inflammatory disease, vaginitis, furuncle, burn and scald.
Flos kerriae japonicae: base is former: be flower or the branch and leaf of rosaceous plant Flos kerriae japonicae and polyphyll Flos kerriae japonicae.The property of medicine: bitter, puckery, flat.Return lung, stomach, spleen channel.Function cures mainly: preventing phlegm from forming and stopping coughing, inducing diuresis to remove edema, removing toxic substances.Main cough, rheumatic arthralgia, puerperal impairment caused by overstrain pain, edema, dysuria, dyspepsia, swollen ulcer drug, eczema, urticaria.
Fructus Rubi: base is former: be the dry fruit of Rosaceae rubus rubus chingii Hu.The property of medicine: sweet, sour, temperature.Return kidney, urinary bladder channel.Function cures mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea.
Semen Sojae Preparatum: base is former: for the mature seed of the black of legume soybean processes through steaming net for catching birds or fish fermentation etc.The property of medicine: bitter, pungent, flat.Return lung, stomach, the heart, bladder, small intestinal, tri-jiao channel.Function cures mainly: expelling pathogenic factors from muscles is delivered, and declares strongly fragrant relieving restlessness.Main diseases caused by exogenous pathogenic factor exterior syndrome, cold and heat are had a headache, vexed, uncomfortable in chest.
Nux Prinsepiae: base is former: be the kernel of rosaceous plant list flower Folium Prinsepiae Utilis.The property of medicine: sweet, cold, nontoxic.Return liver, the heart, spleen, lung meridian.Function cures mainly: wind and heat eliminating, and nourishing the liver to improve visual acuity is calmed the nerves.Main conjunctival congestion and swelling pain, dim photophobia, the rotten many tear of the corner of the eyes, uneasy sleeping at night.Frying Nux Prinsepiae is the processed product of Nux Prinsepiae.Fry Nux Prinsepiae kidney tonifying heat clearing and tranquillizing.
Jujube nucleus: another name Semen Ziziphi Spinosae, Fructus Choerospondiatis, Semen Ziziphi Spinosae are Rhamnaceae plant Ziziphi Spinosae dry mature seed.The property of medicine: sweet, sour, flat.Return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.Semen Ziziphi Spinosae (parched): get clean Semen Ziziphi Spinosae, put in pot to fry with slow fire and to heave to crust and be micro-yellow, taking-up, cools.Effect of Semen Ziziphi Spinosae (parched) and effect: nourishing the liver, mind calming, calms the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.
Raw Semen Cuscutae: base is former: be the dry mature seed of convolvulus cuscuta plant.The property of medicine: sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down, externally treating leucoderma.
The Rhizoma Pinelliae: base is former: be the tuber of the Araeceae Rhizoma Pinelliae.The property of medicine: pungent, temperature, poisonous.Return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For cough due to damp-phlegm, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus, gall subcutaneous nodule, swollen ulcer drug.Rhizoma Pinelliae is Rhizoma Pinelliae with 20% Alumen be that adjuvant obtains through concocting.Rhizoma Pinelliae, is longer than fresh breeze expectorant, dissipating fluid-retention, the loose feeling of stuffiness in chest, sending down the abnormal ascending QI cough-relieving.
Bulbus Fritillariae Thunbergii: base is former: be the bulb of liliaceous plant Bulbus Fritillariae Thunbergii.The property of medicine: bitter in the mouth, cold in nature.Return lung, heart channel.Function cures mainly: removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, mass dissipating and swelling eliminating.Main air heat or phlegm-heat cough, lung abscess vomiting pus, scrofula goiter, sore and toxic.
Sargassum: base is former: be the frond of Sargassaceae plant Sargassum fusiforme (Harv.) Setch and Sargassum.The property of medicine: bitter, salty, cold.Return lung, spleen, kidney, liver stomach warp.Function cures mainly: softening the hard mass, expectorant, diuretic, detumescent.Main scrofula, goiter, gathers, edema, beriberi, painful and swollen testis, (Epileptic is ruined) hernia.
Concha Ostreae: be the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.The property of medicine: salty, is slightly cold.Return liver, gallbladder, kidney channel.Function cures mainly: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, and hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule ， mass in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.
Radix Angelicae Sinensis: base is former: be the dry root of umbelliferae angelica.The property of medicine: sweet, acrid, warm.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, traumatic injury, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, traumatic injury.
Rhizoma Dioscoreae: base is former: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.The property of medicine: sweet, flat.Return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.
Pericarpium Citri Reticulatae: base is former: be the dry mature skin of rutaceae orange and variety thereof.The property of medicine: bitter, pungent, temperature.Return lung, spleen channel.Function cures mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Flos Carthami: base is former: be the dried floral of feverfew Flos Carthami.The property of medicine: pungent, temperature.GUIXIN, Liver Channel.Function cures mainly: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, traumatic injury, skin infection swells and ache.
Fructus Corni: base is former: be the sarcocarp of Cornaceae plant Fructus Corni.The property of medicine: sour, puckery, tepor.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed, and interior-heat is quenched one's thirst.
Radix Trichosanthis: base is former: be the root of cucurbitaceous plant Fructus Trichosanthis and Chinese Fructus Trichosanthis.The property of medicine: sweet in the mouth, micro-hardship, cold nature.Attach to the lung and stomach meridians.Function cures mainly: clearing away heat and promoting production of body fluid, moistening the lung and resolving phlegm, and row is dense in detumescence.Main calentura is thirsty, polydipsia of quenching one's thirst, lung-heat type cough, sore swollen toxin.
Semen Platycladi: base is former: be the kernel of Cupressaceae plant Cacumen Platycladi.Main component: containing significant quantities of fat oil and a small amount of volatile oil, and containing Saponin.The property of medicine: sweet, flat.GUIXIN, kidney, large intestine channel.Function cures mainly: tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, the diseases such as dryness of the intestine constipation.
test example 1the clinical practice of the Chinese medicine (embodiment 5) of gained treatment hyperthyroidism of the present invention: in February ,-2011 in February, 2009,272 routine patients with hyperthyroidisms are screened in 6 hospitals, wherein male 112 example, women 160 example, oldest 66 years old, minimum 21 years old of age, 38 years old mean age, the course of disease 5 months-8 years, average 3.5 years.Be divided into two groups at random, experimental group and matched group (often organizing 136 people).Experimental group male 56 example, women 80 example, oldest 66 years old, minimum 21 years old of age, 38 years old mean age, the course of disease 5 months-8 years, average 3.5 years.Matched group male 56 example, women 80 example, oldest 66 years old, minimum 21 years old of age, 38 years old mean age, the course of disease 5 months-8 years, average 3.5 years.Two groups of patients compare at age, sex, the course of disease and severe extent, and there are no significant for difference (P > 0.05), has comparability.
Diagnostic criteria
Draft with reference to the related standards in " new Chinese medicine guideline of clinical investigations ".Western medicine diagnose standard: clinical manifestation: anxiety, nervous, emotional, absent minded, To Be Protected from Heat, hyperhidrosis, skin hygropyrexia, fine tremor, and bulimia, becomes thin, and times of defecation increases, menoxenia.The enhancing of tachycardia, hear sounds, pulse pressure difference increase, premature beat, atrial fibrillation etc.Thyroid anthorisma, can there be fine tremor and vascular murmur in local.Can with or without exophthalmos, minority companion pretibial myxedema.Physico-chemical examination: TT
3, TT
4, FT
3, FT
4in raising in various degree, thyrotropin (TSH) level is normal or reduce; B ultrasonic supports thyroid diffusivity hypertrophy.
Tcm diagnosis standard: primary symptom: throat enlargement, palpitation and uneasiness, has a dizzy spell, order is swollen many tear, and irritable, finger trembles, bitter taste glossodynia, distending pain in the chest and hypochondrium.Secondary disease: polyphagia is become thin, aversion to heat hyperhidrosis, little sleep disturbed by dreams, fatigue and weakness, thirsty polydipsia.Red tongue, the few Tianjin of tongue fur BOHUANG, wiry and frequent pulse.
Exclusion standard
Gestation or women breast-feeding their children; Merge primary disease, the psychotics such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system; The person that has hyperthyroidism crisis; Thyroid remarkable enlargement compressing adjacent organs person; Long-term taking is correlated with Western medicine, can not drug withdrawal person; Various thyroiditis; Allergic constitution or (with) to multi-medicament allergy sufferers.
Therapeutic Method: experimental group uses gained of the present invention to treat the Chinese medicine of hyperthyroidism, and using method: boiled water is taken after mixing it with water, every day three times, each 5g seven days is a course for the treatment of, totally four courses for the treatment of.Matched group uses the medicine (as propylthiouracil enteric coatel tablets, carbimazole sheet, metoprolol tartrate tablets, Thiamazole tablets etc.) of conventional therapy hyperthyroidism, within seven days, is a course for the treatment of, totally four courses for the treatment of.
Curative effect situation criterion: cure: clinical symptom disappearance, goiter, expophthalmos and relevant sign recover normal substantially, thyroid function recovers normal.Effective: clinical symptoms disappears substantially, goiter, expophthalmos and relevant sign obviously alleviate, and thyroid function checks close to normal.Take a turn for the better: clinical symptoms is clearly better, and thyroid arsine, expophthalmos and relevant sign alleviate to some extent, and thyroid function inspection takes a turn for the better to some extent.Invalid: clinical symptoms and sign without improvement, T
3, T
4unchanged, thyroid function checks without changing.Total effectively comprising cures and effective.After treating four courses for the treatment of, result is as shown in table 1.
Table 1: the Chinese medicine compliance test result [example (%)] of gained treatment hyperthyroidism of the present invention
Therapeutic effect: in 136 routine patients of experimental group, cures 87 examples, accounts for 63.97%; Effective 46 examples, account for 33.82%; Take a turn for the better 2 examples, accounts for 1.47%; Invalid 1 example, account for 0.74%, total effective rate reaches 97.79%.In 136 routine patients of matched group, cure 43 examples, account for 31.62%; Effective 49 examples, account for 36.03%; Take a turn for the better 33 examples, accounts for 24.26%; Invalid 11 examples, account for 8.09%, total effective rate 67.65%.Experimental group total effective rate is obviously better than matched group, and two groups of comparing differences have significance.
The present invention for instructing, carries out scientific composition with traditional Chinese medical science traditional theory, selects the Chinese crude drugs such as Fructus Amomi, the Cortex Eucommiae, Caulis Fibraureae, Flos kerriae japonicae and Fructus Rubi to be primary raw material, makes the Chinese medicine for the treatment of hyperthyroidism.The wet appetizing of side's medium sand Renhua, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, warming spleen and stopping diarrha, antiabortive.Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Caulis Fibraureae heat-clearing and toxic substances removing, dampness removing.Flos kerriae japonicae preventing phlegm from forming and stopping coughing, inducing diuresis to remove edema, removing toxic substances.Fructus Rubi kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.Semen Sojae Preparatum expelling pathogenic factors from muscles is delivered, and declares strongly fragrant relieving restlessness.Fry Nux Prinsepiae kidney tonifying heat clearing and tranquillizing.Semen Ziziphi Spinosae (parched) nourishing the liver, mind calming, calms the nerves, arresting sweating.Raw Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.Rhizoma Pinelliae fresh breeze expectorant, dissipating fluid-retention, the loose feeling of stuffiness in chest, sending down the abnormal ascending QI cough-relieving.Bulbus Fritillariae Thunbergii removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, mass dissipating and swelling eliminating.Sargassum softening the hard mass, expectorant, diuretic, detumescent.Concha Ostreae tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, restrains astringent or styptic treatment for spontaneous sweating.Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Fructus Corni liver and kidney tonifying, essence astringing and desertion stemming.Radix Trichosanthis clearing away heat and promoting production of body fluid, moistening the lung and resolving phlegm, row is dense in detumescence.Semen Platycladi tranquilizing by nourishing the heart, loosening bowel to relieve constipation.All medicines share, play the strongly fragrant relieving restlessness of a surname, nourishing the liver and kidney, drying dampness to eliminate phlegm, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving altogether, enrich blood invigorate blood circulation, effect of regulating qi-flowing for strengthening spleen, tranquilizing by nourishing the heart, amount to strengthening vital QI to eliminate pathogenic factors, the merit for the treatment of both the principal and the secondary aspects of a disease at the same time.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat the Chinese medicine of hyperthyroidism, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Amomi 10-20, Cortex Eucommiae 8-15, Caulis Fibraureae 6-9, Flos kerriae japonicae 5-10, Fructus Rubi 10-15, Semen Sojae Preparatum 10-20, fry Nux Prinsepiae 5-10, Semen Ziziphi Spinosae (parched) 15-20, raw Semen Cuscutae 9-16, Rhizoma Pinelliae 8-12, Bulbus Fritillariae Thunbergii 8-12, Sargassum 8-12, Concha Ostreae 5-10, Radix Angelicae Sinensis 10-20, Rhizoma Dioscoreae 10-20, Pericarpium Citri Reticulatae 9-16, Flos Carthami 8-12, Fructus Corni 7-15, Radix Trichosanthis 10-20, Semen Platycladi 15-20.
2. the Chinese medicine for the treatment of hyperthyroidism as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Amomi 14-18, Cortex Eucommiae 10-13, Caulis Fibraureae 7-8.5, Flos kerriae japonicae 6-8, Fructus Rubi 11-14, Semen Sojae Preparatum 13-16, fries Nux Prinsepiae 6-8, Semen Ziziphi Spinosae (parched) 16-18, raw Semen Cuscutae 11-14, Rhizoma Pinelliae 9-11, Bulbus Fritillariae Thunbergii 9-11, Sargassum 9-11, Concha Ostreae 6.5-8, Radix Angelicae Sinensis 15-18, Rhizoma Dioscoreae 14-17, Pericarpium Citri Reticulatae 12-15, Flos Carthami 9-11, Fructus Corni 9-13, Radix Trichosanthis 12-17, Semen Platycladi 16-18.
3. the Chinese medicine for the treatment of hyperthyroidism as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Fructus Amomi 16, the Cortex Eucommiae 11, Caulis Fibraureae 7.5, Flos kerriae japonicae 7, Fructus Rubi 12, Semen Sojae Preparatum 14, fry Nux Prinsepiae 7, Semen Ziziphi Spinosae (parched) 17, raw Semen Cuscutae 12, Rhizoma Pinelliae 10, Bulbus Fritillariae Thunbergii 10, Sargassum 10, Concha Ostreae 7, Radix Angelicae Sinensis 16, Rhizoma Dioscoreae 15, Pericarpium Citri Reticulatae 14, Flos Carthami 10, Fructus Corni 11, Radix Trichosanthis 14, Semen Platycladi 17.
4. the Chinese medicine of the treatment hyperthyroidism as described in as arbitrary in claims 1 to 3, it is characterized in that, the Chinese medicine of this treatment hyperthyroidism is made pharmaceutically acceptable pill, and the preparation method of described pill is:
(1) refined honey is got, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is the weight of the preferred refined honey of 1/4-1/2(of Bulbus Fritillariae Thunbergii weight is 1/3 of Bulbus Fritillariae Thunbergii weight), after moistening 1.5-3 hour (preferred moistening is after 2.5 hours), put in hot pot, heat with slow fire, fry to time tack-free, take out, cool, be ground into fine powder, cross No. five sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 18-32 hour (preferably Semen Platycladi 50 degree of rice wine being soaked 28 hours), the consumption of rice wine is 2.5-3.5 times (consumption of preferred rice wine is 3 times of Semen Platycladi weight) of Semen Platycladi weight, Semen Platycladi after soaking is leached, dry, be ground into fine powder, cross No. five sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, with the general ball of step (2) gained filtrate, make the pill (preferably making every ball weight is the pill of 0.2g) that every ball weight is 0.15-0.25g, adopt fluid bed airpillow-dry, temperature controls at 55-60 DEG C, and by the water content control of pill below 6%.
5. the Chinese medicine of the treatment hyperthyroidism as described in as arbitrary in claims 1 to 3, it is characterized in that, the Chinese medicine of this treatment hyperthyroidism is made pharmaceutically acceptable thick paste agent, and the preparation method of described thick paste agent is:
(1) refined honey is got, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is the weight of the preferred refined honey of 1/4-1/2(of Bulbus Fritillariae Thunbergii weight is 1/3 of Bulbus Fritillariae Thunbergii weight), after moistening 1.5-3 hour (preferred moistening is after 2.5 hours), put in hot pot, heat with slow fire, fry to time tack-free, take out, cool, be ground into fine powder, cross No. six sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 18-32 hour (preferably Semen Platycladi 50 degree of rice wine being soaked 28 hours), the consumption of rice wine is 2.5-3.5 times (consumption of preferred rice wine is 3 times of Semen Platycladi weight) of Semen Platycladi weight, Semen Platycladi after soaking is leached, dry, be ground into fine powder, cross No. six sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are put into marmite, decoct with water twice, amount of water is the 3.7-5.4 of 18 taste crude drug gross weights doubly (preferred amount of water is 4.5 times of 18 taste crude drug gross weights), first boil with high heat to boiling, after turn slow fire boiling 1.3-1.6 hour (preferably then turn slow fire boiling 1.5 hours), merge medicinal liquid, filter;
(4) step (2) gained filtrate and step (3) gained medicinal liquid are merged, be concentrated into the clear paste (being preferably concentrated into the clear paste of relative density 1.25) of relative density 1.23-1.27, add refined honey, every 100kg clear paste adds the preferred every 100kg clear paste of refined honey 155-175kg(and adds refined honey 160kg), finally add step (1) and step (2) gained fine powder is mixed well, be divided in the container of clean dried sterilizing, covered and enclosed after fully cooling.
6. the Chinese medicine of the treatment hyperthyroidism as described in as arbitrary in claims 1 to 3, it is characterized in that, the Chinese medicine of this treatment hyperthyroidism is made pharmaceutically acceptable granule, and the preparation method of described granule is:
(1) refined honey is got, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is the weight of the preferred refined honey of 1/4-1/2(of Bulbus Fritillariae Thunbergii weight is 1/3 of Bulbus Fritillariae Thunbergii weight), after moistening 1.5-3 hour (preferred moistening is after 2.5 hours), put in hot pot, heat with slow fire, fry to time tack-free, take out, cool, be ground into fine powder, cross No. five sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 18-32 hour (preferably Semen Platycladi 50 degree of rice wine being soaked 28 hours), the consumption of rice wine is 2.5-3.5 times (consumption of preferred rice wine is 3 times of Semen Platycladi weight) of Semen Platycladi weight, Semen Platycladi after soaking is leached, dry, be ground into fine powder, cross No. five sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, then make altogether with 15% starch slurry and step (2) gained filtrate, the weight of starch is 1.0-1.3 times (weight of preferred starch is 1.2 times of gained fine powder gross weight) of gained fine powder gross weight;
(5) by step (4) fashion of extrusion that is able to by 16-20 eye mesh screen (preferably by step (4) fashion of extrusion that is able to logical 18 eye mesh screens), make uniform granule;
(6) step (5) gained granule is adopted fluid bed airpillow-dry, temperature controls at 60-65 DEG C, the water content control of granule within 2%, granulate subpackage and get final product.
7. the Chinese medicine of the treatment hyperthyroidism as described in as arbitrary in claims 1 to 3, it is characterized in that, the Chinese medicine of this treatment hyperthyroidism is made pharmaceutically acceptable tablet, and the preparation method of described tablet is:
(1) get refined honey, mix thoroughly with Bulbus Fritillariae Thunbergii, the weight of refined honey is the 1/4-1/2 of Bulbus Fritillariae Thunbergii weight, after moistening 1.5-3 hour, puts in hot pot, with slow fire heating, fries to time tack-free, takes out, cool, be ground into fine powder, cross No. five sieves;
(2) Semen Platycladi 50 degree of rice wine are soaked 18-32 hour, the consumption of rice wine is 2.5-3.5 times (consumption of preferred rice wine is 3 times of Semen Platycladi weight) of Semen Platycladi weight, is leached by the Semen Platycladi after soaking, dry, be ground into fine powder, cross No. five sieves, filtrate is for subsequent use;
(3) all the other the 18 taste crude drug except Bulbus Fritillariae Thunbergii and Semen Platycladi are ground into fine powder respectively, cross No. five sieves;
(4) step (1), step (2) and step (3) gained fine powder are fully mixed, then make altogether with 15% starch slurry, the weight of starch is 1.0-1.3 times (weight of preferred starch is 1.2 times of gained fine powder gross weight) of gained fine powder gross weight;
(5) by step (4) fashion of extrusion that is able to by 16-20 eye mesh screen (preferably by step (4) fashion of extrusion that is able to by 18 eye mesh screens), make uniform granule;
(6) step (5) gained granule is adopted fluid bed airpillow-dry, temperature controls at 60-65 DEG C, and the water content control of granule, within 2%, adds step (2) gained filtrate, mixing, tabletting, and the heavy 0.2g of every sheet, to obtain final product.
8. the preparation method of the Chinese medicine tablet for the treatment of hyperthyroidism as claimed in claim 7, it is characterized in that, in step (1), the weight of refined honey is 1/3 of Bulbus Fritillariae Thunbergii weight.
9. the preparation method of the Chinese medicine tablet for the treatment of hyperthyroidism as claimed in claim 7, it is characterized in that, in step (1), moistening is after 2.5 hours.
10. the preparation method of the Chinese medicine tablet for the treatment of hyperthyroidism as claimed in claim 7, is characterized in that, in step (2), Semen Platycladi 50 degree of rice wine are soaked 28 hours.
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| CN106822674A (en) * | 2017-01-06 | 2017-06-13 | 蚌埠丰原涂山制药有限公司 | The pharmaceutical composition of hyperthyroidism is treated, containing its preparation and preparation method and application |
| CN112138067A (en) * | 2020-10-12 | 2020-12-29 | 青岛大学附属医院 | Traditional Chinese medicine for treating iodine refractory differentiated thyroid cancer and application |
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| CN101152511A (en) * | 2007-09-17 | 2008-04-02 | 李广欣 | Medicament for treating hyperthyroidism disease and method of preparing the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106822674A (en) * | 2017-01-06 | 2017-06-13 | 蚌埠丰原涂山制药有限公司 | The pharmaceutical composition of hyperthyroidism is treated, containing its preparation and preparation method and application |
| CN106822674B (en) * | 2017-01-06 | 2020-04-07 | 蚌埠丰原涂山制药有限公司 | Pharmaceutical composition for treating hyperthyroidism, preparation containing pharmaceutical composition, preparation method and application of pharmaceutical composition |
| CN112138067A (en) * | 2020-10-12 | 2020-12-29 | 青岛大学附属医院 | Traditional Chinese medicine for treating iodine refractory differentiated thyroid cancer and application |
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