CN103212030A - Traditional Chinese medicine for treating liver depression type hyperplasia of mammary glands and preparation method thereof - Google Patents
Traditional Chinese medicine for treating liver depression type hyperplasia of mammary glands and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for treating liver depression type hyperplasia of mammary glands and a preparation method thereof. The traditional Chinese medicine comprises the following raw herbal materials: akebiae fructus, rhizoma cyperi, szechwan chinaberry fruit, elecampane, cortex albiziae, algae, radix curcumae, green malt, radix paeoniae rubra, radix bupleuri, fructus aurantii, curcuma zedoary, pericarpium citri reticulatae viride, immature bitter orange, ligusticum wallichii, spina gleditsiae, thunberg fritillary bulb, tangerine leaf, fructus psoraleae and centipede. According to the treatment principle based on depression resolution and stasis dissolution, the traditional Chinese medicine provided by the invention is capable of well treating the liver depression type hyperplasia of mammary glands by using medicines which function in soothing the liver to resolve the depression, promoting the qi circulation to relieve the pain, relieving the stagnant qi to remove the qi stagnation and dissolving the phlegm to remove the stasis, so that the shackle that the traditional Western therapies such as traditional operations, antibiotics and the like only simply eliminate the lumps is broken, the defect of easy relapse is overcome, the defect that the Chinese patent drugs cannot suit the remedy to the case is overcome, and the advantages of strong pertinence, short course of treatment, rapid effect and difficult relapse are provided.
Description
Technical field
The present invention relates to the Chinese medicine field of engineering technology, relate in particular to a kind of Chinese medicine and preparation method for the treatment of the liver energy stagnation type cyclomastopathy.
Background technology
Add up according to World Health Organization (WHO): 20～45 years old reproduction age the female mammary gland proliferation sickness rate up to 50%, global cyclomastopathy patient surpasses 1,000,000,000, owing to lack unified treatment standard and scientific and effective Therapeutic Method at present, the canceration rate of cyclomastopathy is growing, dies from nearly 200,000,000 people of women of cyclomastopathy every year.The international expert of breast disease association (SIS) the NGO particular study mechanism that calls upon States for a long time, and strengthen input to curing mammary gland hyperplasia method and drug research, the early settlement cyclomastopathy is cured a difficult problem.
Cyclomastopathy is the modal cystic hyperplasia of breast of women, and its sickness rate accounts for the first place of mastopathy.Should be the trend that rises year by year by the disease sickness rate in the last few years, the age also more and more becomes younger.In adolescence or young women, warp before has distending pain of the breast, pain can involve the shoulder back sometimes, through the spontaneous remission gradually of rear udder attachment pain, only can contact mammary gland and thicken a bit, not have obvious tuberosity, these are that physiological changes, not disease, do not need treatment yet, belong to physiological hypertrophy.Cyclomastopathy is normal breast lobule physiological hypertrophy and subinvolution, and the mammary gland normal configuration gets muddled, and belongs to pathological proliferation, and it is neither an inflammation class disease of non-tumor again.Be mainly in 30-50 year women, onset peak is 35-40 year.
At present, think that cyclomastopathy and endocrine disturbance and spirit, environmental factors etc. are relevant more.
1, endocrine disturbance.The lutein secretion reduces, and it is the major reason of cyclomastopathy morbidity that estrogen increases relatively., menoxenia unsound, thyroid disease and hepatic insufficiency etc. as the development of ovary.
2. the influence of Nervous and Mental Factors such as emotion.Psychentonia, bad Nervous and Mental Factors such as excited form cyclomastopathy easily, and often stay up late, do not have enough sleep etc. also can be caused cyclomastopathy, and these undesirable elements also can increase the weight of existing cyclomastopathy symptom.
3. anthropic factor or bad life habits: reasons such as sterile, sexual life imbalance at women advanced age, artificial abortion, man and wife's discord, not suckling, cause that mammary gland can not have normally, periodic physiological activity.Wear the medicated bra of tension or pass tight underwear or the like.
4. dietary structure is unreasonable, causes fatty Excessive Intake as high fat, high-energy diet, drinks and bad life habits such as smoking can be brought out breast disease.In addition, people's diet has been got well now, has the people of hypertension, hyperglycemia also a lot, and these also make the women endocrine disturbance occur easily, cause cyclomastopathy.
5. take for a long time and contain estrogenic health product, contraceptive.The long-term excessive absorption estrogen of human body will cause the incretion balance imbalance, and also hormone compositions that contain in the feedstuff that some fast foods, artificial breeding's Aquatic product and poultry are used eat the generation that also can cause mastopathy for a long time now.
At present, doctor trained in Western medicine is to primary disease more perfect Therapeutic Method and the medicine of neither one also, mainly be to adopt hormone to come to treatment-resistant and surgical removal, medicine commonly used has 5% potassium iodide and tamoxifen etc., the pain severe patient can be tried out methyl testosterone or tamoxifen, generally need be in menstruation the last week beginning oral, in order to avoid further upset trickle balance between the human hormone, because of primary disease is a chronic disease, take hormone medicine for a long time, can only play analgesic effect, and side effect is big, if perform an operation, damage surface is big, cures the symptoms, not the disease, again recurrence easily, patient is difficult to accept; Chang Yong medicine majority is a Chinese patent medicine clinically, have effects such as blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating, hard masses softening and resolving, compensate qi and blood, therapeutic effect is also comparatively desirable, such as ease pill, little gold plaque, nodules of the breast ball, Xi Huan Wan, LIUWEI DIHUANG WAN, ERZHI WAN, XIAOJIN DAN, eliminating stagnation spirit, RUKUAIXIAO capsule, RUZENGNING PIAN, RUKUAIXIAO PIAN, eliminating stagnation nodules of the breast cream etc., but because Chinese patent medicine prescription and content are fixed, can't suitably adjust composition or content in the prescription, can't realize suiting the remedy to the case according to every patient's concrete condition.
Cyclomastopathy can be subdivided into phlegm-damp type, liver energy stagnation type, blood-deficiency type and renal deficiency type again on the traditional Chinese medical science
Phlegm-damp type: patient's body is how fat, or many diseases, or asthenia is drowsiness, and the patient skin grease that has is more, body odour obviously, or leucorrhea is many and yellow slightly partially, stool thickness and freely not suitable, or often cough up phlegm, red tongue, tongue fur slightly Huang are thick, breast has a dull ache during menstrual onset.Treatment is worked as wet to reduce phlegm, diffusing breast and is become the master.
Liver energy stagnation type: disease is seen menstruation time of tide in the future, distending pain of the breast, hypertrophy lobule pain is obvious especially, when angry then distending pain of the breast more very, easily disgruntled usually, body of the tongue is dark and gloomy partially, or it is not good enough to sleep.It is main that treatment is worked as with the resolving depression eliminating stagnation.
Blood-deficiency type: pale complexion is matt or sallow, fatigue and asthenia, and lip, fingernail are light white, and the menstruation color is light red, and the cyclomastopathy district has a dull ache when passing through, and pulse is thin and unable.Treatment is worked as based on the eliminating stagnation of enriching blood.
Renal deficiency type: disease is seen soreness of the waist and knees, and lower limb are weak, or tinnitus, night many urine, hyposexuality, forgetful, or clear and thin leucorrhea, during menstrual onset, breast has a dull ache, pale tongue, pulse heavy thin (promptly slightly heavily can touch by beginning with finger).Treatment is worked as based on the kidney invigorating eliminating stagnation.
So, with the traditional western medical treatment method and the Therapeutic Method and the medicine of single Chinese patent medicine, treat, can only play the effect of pain relieving and relief of symptoms in early days temporarily, can not tackle the problem at its root, thereby cause the outbreak repeatedly of disease, chronic disease of easily examining refractory really of cyclomastopathy, but,, can cure fully as long as can seek a good method and drug effect well.Though disease one, method of treatment is different, though be both cyclomastopathy, the clinical symptoms that every patient showed is also different, the individual difference difference of stopping, can not thousand people, one side, no matter ten thousand people, one medicine is Zhang San, Li Si is fixedly medication merely, effect is poor like this, not only controls bad disease, on the contrary recurrence easily, must be when the treatment primary disease according to the ultimate principle of differentiation of tcm, in conjunction with the different characteristics of patient's morbidity, adopt systematicness, personalized, best occasion for the treatment is grasped in the concrete concrete medication of the state of an illness, the science diagnosis, could find out the disease root accurately and effectively like this, treatment is avoided detours the patient targetedly, spend less, reach a cure.
Summary of the invention
Technical problem to be solved by this invention is, utilize the traditional theory of Chinese medical science of China, a kind of Chinese medicine of novel treatment liver energy stagnation type cyclomastopathy is provided, according to Therapeutic Principle based on the resolving depression eliminating stagnation, medicine with dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, dispelling the stagnated QI removing food stagnancy, vanishing sputum and dispelling knot is well treated the liver energy stagnation type cyclomastopathy, the only yoke of simple property elimination lump of traditional western medicine therapies such as operation, antibiotic that breaks traditions is eliminated the defective of easily recurrence and is overcome Chinese patent medicine and can not realize the shortcoming of suiting the remedy to the case.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of the liver energy stagnation type cyclomastopathy, wherein, comprise following raw medicinal material in the described Chinese medicine: Fructus Akebiae, Rhizoma Cyperi, Fructus Toosendan, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Sargassum, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Rhizoma Chuanxiong, Spina Gleditsiae, Bulbus Fritillariae Thunbergii, Folium Citri tangerinae, Fructus Psoraleae and Scolopendra.
The ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can be preferably: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine is: Fructus Akebiae 20～45 weight portions, Rhizoma Cyperi 10～25 weight portions, Fructus Toosendan 20～35 weight portions, the Radix Aucklandiae 15～25 weight portions, Cortex Albiziae 15～25 weight portions, Radix Curcumae 20～30 weight portions, Sargassum 20～40 weight portions, Fructus Hordei Germinatus 25～40 weight portions, Radix Paeoniae Rubra 10～20 weight portions, Radix Bupleuri 10～25 weight portions, Fructus Aurantii 15～25 weight portions, Rhizoma Curcumae 10～30 weight portions, Pericarpium Citri Reticulatae Viride 10～15 weight portions, Fructus Aurantii Immaturus 15～35 weight portions, Rhizoma Chuanxiong 5～15 weight portions, Spina Gleditsiae 10～20 weight portions, Bulbus Fritillariae Thunbergii 15～30 weight portions, Folium Citri tangerinae 10～25 weight portions, Fructus Psoraleae 25～40 weight portions and Scolopendra 6～15 weight portions.
The ratio of weight and number of the various raw medicinal materials in the described Chinese medicine also can be preferably: Fructus Akebiae 20～35 weight portions, Rhizoma Cyperi 10～20 weight portions, Fructus Toosendan 20～30 weight portions, the Radix Aucklandiae 20～25 weight portions, Cortex Albiziae 15～20 weight portions, Radix Curcumae 25～30 weight portions, Sargassum 30～40 weight portions, Fructus Hordei Germinatus 25～30 weight portions, Radix Paeoniae Rubra 10～15 weight portions, Radix Bupleuri 15～25 weight portions, Fructus Aurantii 15～20 weight portions, Rhizoma Curcumae 20～30 weight portions, Pericarpium Citri Reticulatae Viride 10～12 weight portions, Fructus Aurantii Immaturus 15～25 weight portions, Rhizoma Chuanxiong 10～15 weight portions, Spina Gleditsiae 10～15 weight portions, Bulbus Fritillariae Thunbergii 20～30 weight portions, Folium Citri tangerinae 10～20 weight portions, Fructus Psoraleae 25～30 weight portions and Scolopendra 8～12 weight portions.
The ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can also be preferably: Fructus Akebiae 30 weight portions, Rhizoma Cyperi 12 weight portions, Fructus Toosendan 25 weight portions, the Radix Aucklandiae 22 weight portions, Cortex Albiziae 18 weight portions, Radix Curcumae 25 weight portions, Sargassum 32 weight portions, Fructus Hordei Germinatus 28 weight portions, Radix Paeoniae Rubra 14 weight portions, Radix Bupleuri 20 weight portions, Fructus Aurantii 16 weight portions, Rhizoma Curcumae 25 weight portions, Pericarpium Citri Reticulatae Viride 12 weight portions, Fructus Aurantii Immaturus 20 weight portions, Rhizoma Chuanxiong 12 weight portions, Spina Gleditsiae 10 weight portions, Bulbus Fritillariae Thunbergii 30 weight portions, Folium Citri tangerinae 16 weight portions, Fructus Psoraleae 28 weight portions and Scolopendra 10 weight portions.
When the dosage form of described Chinese medicine was powder, its preparation method may further comprise the steps:
The first step is mixed in proportion described raw medicinal material, is ground into powder;
Second step obtained powder with the first step and adds in the cold water and soaked 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains first filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtains of the first step;
In the 3rd step, the filtering residue that second step filter was obtained adds in the cold water once more, with slow fire boiling 2 hours～4 hours, filters and obtains second filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtained in second step;
The 4th step, first filtrate of second step acquisition and second filtrate of the 3rd step acquisition are mixed, concentrating under reduced pressure removes and anhydrates, and drying is ground into powder, and granularity is 80～120 orders;
The 5th step in the powder that obtains in described the 4th step, added starch, and the percentage by weight of described starch in described powder is 15%～30%, and with pouch or packing box packing, per 5～10 grams are one bag or a box packing with the material behind the mixing.
When the dosage form of described Chinese medicine is an oral solutions, its preparation method may further comprise the steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, with determining alcohol is that 70%～80% methanol is as solvent, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that is added is 3～5 times of first step mixture quality;
Second step was mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, was ground into powder;
The 3rd step added the distilled water of 3～6 times of the powder qualities that obtain with respect to second step, decocted filtration 2～4 hours, obtain first filtrate,, decocted 1～2 hour the distilled water of filtering residue adding with respect to 2～4 times of its quality, filter, obtain second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, the adding determining alcohol is 90～95% ethanol, makes determining alcohol reach 70%～80%, left standstill 12～24 hours, and filtered concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;
In the 4th step, the powder mixes with second step and the acquisition of the 3rd step adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilization promptly obtains oral liquid.
In order to solve the problems of the technologies described above, the present invention provides a kind of above-mentioned prescription preparation method of Chinese medicine again, and the dosage form of described Chinese medicine is a powder, and it may further comprise the steps:
The first step is mixed in proportion described raw medicinal material, is ground into powder;
Second step obtained powder with the first step and adds in the cold water and soaked 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains first filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtains of the first step;
In the 3rd step, the filtering residue that second step filter was obtained adds in the cold water once more, with slow fire boiling 2 hours～4 hours, filters and obtains second filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtained in second step;
The 4th step, first filtrate of second step acquisition and second filtrate of the 3rd step acquisition are mixed, concentrating under reduced pressure removes and anhydrates, and drying is ground into powder, and granularity is 80～120 orders;
The 5th step in the powder that obtains in described the 4th step, added starch, and the percentage by weight of described starch in described powder is 15%～30%, and with pouch or packing box packing, per 5～10 grams are one bag or a box packing with the material behind the mixing.
In order to solve the problems of the technologies described above, the present invention provides a kind of above-mentioned prescription preparation method of Chinese medicine again, and the dosage form of described Chinese medicine is an oral solutions, and it may further comprise the steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, with determining alcohol is that 70%～80% methanol is as solvent, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that is added is 3～5 times of first step mixture quality;
Second step was mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, was ground into powder;
The 3rd step added the distilled water of 3～6 times of the powder qualities that obtain with respect to second step, decocted filtration 2～4 hours, obtain first filtrate,, decocted 1～2 hour the distilled water of filtering residue adding with respect to 2～4 times of its quality, filter, obtain second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, the adding determining alcohol is 90～95% ethanol, makes determining alcohol reach 70%～80%, left standstill 12～24 hours, and filtered concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;
In the 4th step, the powder mixes with second step and the acquisition of the 3rd step adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilization promptly obtains oral liquid.
Beneficial effect of the present invention:
Chinese medicine provided by the invention, according to Therapeutic Principle based on the resolving depression eliminating stagnation, medicine with dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, dispelling the stagnated QI removing food stagnancy, vanishing sputum and dispelling knot is well treated the liver energy stagnation type cyclomastopathy, the yoke of the only simple property elimination lump of the traditional western medicine therapies such as operation, antibiotic that break traditions, the easy defective of recurrence and overcome Chinese patent medicine and can not realize the shortcoming of suiting the remedy to the case, pointed strong, short treating period, instant effect and be difficult for the advantage of recurrence.
The specific embodiment
The invention provides a kind of Chinese medicine for the treatment of the liver energy stagnation type cyclomastopathy, it comprises: Fructus Akebiae, Rhizoma Cyperi, Fructus Toosendan, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Sargassum, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Rhizoma Chuanxiong, Spina Gleditsiae, Bulbus Fritillariae Thunbergii, Folium Citri tangerinae, Fructus Psoraleae and Scolopendra.
Wherein, Fructus Akebiae, Rhizoma Cyperi, Fructus Toosendan, the Radix Aucklandiae, Radix Bupleuri, Rhizoma Curcumae, Rhizoma Chuanxiong, Cortex Albiziae and Radix Curcumae liver-smoothing, qi-regulating, dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, calming nerves and activating blood circulation; Fructus Aurantii, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus dispelling the stagnated QI removing food stagnancy; The Fructus Hordei Germinatus invigorating the spleen and regulating the stomach, soothing the liver circulation of qi promoting; Radix Paeoniae Rubra, Radix Bupleuri, Spina Gleditsiae dissipating blood stasis for subsidence of swelling; Sargassum, Bulbus Fritillariae Thunbergii, Folium Citri tangerinae, Fructus Psoraleae and Scolopendra eliminating stagnation, expectorant; All medicines share, and realize the function of dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, dispelling the stagnated QI removing food stagnancy, vanishing sputum and dispelling knot.
Various raw medicinal material pharmacology are as follows:
Fructus Akebiae: the wooden ratan of Lardizabalaceae plant threeleaf akebia Akebia trifoliata (Thunb.) Koidz..Bitter in the mouth, cold in nature; Return liver, spleen channel.Liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, dysentery, lumbago, costalgia, hernia, dysmenorrhea, uterus tenesmus.(" Chinese medicine voluminous dictionary ")
Rhizoma Cyperi: acrid in the mouth, little hardship, sweet, property is flat.Dispersing the stagnated live-QI to relieve the stagnation of QI, menstruction regulating and pain relieving is in the accent of regulating the flow of vital energy.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast." detailed outline " carries it: the cold epidemic disease of the seasonal epidemic pathogens that looses, and sharp three warmers are separated six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi is ended trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood, hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in preceding puerperal.
Fructus Toosendan: claim chinaberry reality, Fructus Toosendan, core Fructus Jujubae, Fructus Toosendan, chinaberry, the stone Fructus Evodiae, Fructus Toosendan tree, Fructus Toosendan reality etc. again.Cold in nature, bitter in the mouth; Slightly poisonous.Return liver, small intestinal, urinary bladder channel.The energy soothing liver-QI, promoting the circulation of QI to relieve pain, anthelmintic.Be used for the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.
The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature, return spleen, stomach, large intestine, liver, lung, tri-jiao channel has promoting the circulation of QI to relieve pain, and the effect of strengthening the spleen to promote digestion cures mainly the stagnation of QI in spleen and stomach card, the dysentery tenesmus, the thoracic obstruction, object for appreciation abdominal distention and pain, food stagnation do not disappear cards such as anorexia.
Cortex Albiziae: be the dry bark of pulse family (LeguminOsae) plant Herba Albiziae.Another name: close confused skin (Thousand Golden Prescriptions), CORTEX ALBIZIAE (" side of walking alone "), Herba Albiziae veneer (" detailed outline ").Sweet in the mouth, property are put down.GUIXIN, liver, lung meridian.Resolving stagnation for tranquilization, the eliminating carbuncle of invigorating blood circulation, reuniting the fractured tendons and bones.Cure mainly: irritability, melancholy, sleeplessness, inside and outside carbuncle and ulcer, traumatic injury, blood stasis swells and ache etc.
Radix Curcumae: hot, bitter, cold.Return liver, the heart, lung meridian.Promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.Be used for the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, the amenorrhea dysmenorrhea, distending pain of the breast, the calentura coma, epilepsy is gone mad, and heat in blood is told nosebleed, the jaundice dark coloured urine.
Sargassum: be the dry frond of Sargassaceae plant Sargassum Sargassum pallidum (Turn.) C.Ag. or Sargassum fusiforme (Harv.) Setch Sargassum fusiforme (Harv.) Setch..The former practises title " Da Ye Sargassum ", and the latter practises title " lobule Sargassum ".Summer, Qiu Erji fish, and remove impurity, clean, and dry.Bitter in the mouth, one-tenth, cold in nature.Return liver, stomach, kidney channel.Hard masses softening and resolving, expectorant, diuretic.Be used for goiter, scrofula, painful and swollen testis, phlegm retention edema.
Fructus Hordei Germinatus: sweet, flat.Return spleen, stomach warp.Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite moves back newborn relieving distension.Be used for food stagnation and do not disappear, abdominal distention, insufficiency of the spleen lack of appetite, milk smoulders, distending pain of the breast, women's ablactation.Fructus Hordei Germinatus: invigorating the spleen and regulating the stomach, soothing the liver circulation of qi promoting.Be used for insufficiency of the spleen lack of appetite, milk smoulders.Fructus Hordei Germinatus (parched): promote qi circulation digestion promoting galactopoiesis.Be used for food stagnation and do not disappear, women's ablactation.Fructus Hordei Germinatus (parched to brown): relieving dyspepsia.Be used for food stagnation and do not disappear, abdominal distention.
Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for heat and go into nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, abdominal mass abdominal mass stomachache, injury from falling down, carbuncle skin infection.
Radix Bupleuri: another name: Asia puecon recklessly, smoke Shennong's Herbal, mountain dish, eat grass " WU Pu Bencao ", faggot " product converge smart will ".Cold nature, bitter in the mouth, suffering; GUIXIN bag, liver, gallbladder, tri-jiao channel.Evacuation is brought down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Be used for fever caused by exogenous pathogens, diseases such as the internal organs prolapsus of collapse of QI.Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the uterus comes off, menoxenia.
Fructus Aurantii: bitter, hot, sour, temperature.Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Be used for the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion stops in the phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.
Rhizoma Curcumae: Rhizoma Curcumae original name Rhizoma Curcumae.Beginning is carried " property of medicine opinion ", has another name called PengCurcuma Mao, paulin cowherb, fluffy art, Qiang seven, wide art, evil mind Rhizoma Zingiberis Recens, Rhizoma Curcumae, radix zedoariae, green Rhizoma Zingiberis Recens.Acrid in the mouth, hardship, warm in nature.Return liver, spleen channel.The circulation of qi promoting removing blood stasis, the removing food stagnancy pain relieving.Be used for Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.Cure mainly 1) the removing blood stasis promoting the circulation of QI to relieve pain: this product effect is similar to rhizoma sparganic, but warm concerted effort is bigger, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.2) long-pending eliminating stagnation: this product can the pain relieving of circulation of qi promoting removing food stagnancy, is used for eating accumulation, the breast abdominal distention is vexed has a pain.3) removing blood stasis, women's amenorrhea, or the phlegm-damp congestion lump in the abdomen addiction piece that condenses and form.4) promoting the circulation of QI to relieve pain: be suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever all can.
Pericarpium Citri Reticulatae Viride: bitter, hot, temperature.Return liver, gallbladder, stomach warp.Soothing the liver dispelling the stagnated QI, removing food stagnancyization stagnates.Be used for distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.
Fructus Aurantii Immaturus: bitter, hot, sour, temperature.Return spleen, stomach warp.The dispelling the stagnated QI removing food stagnancy, the diffusing painful abdominal mass of reducing phlegm.Be used for stopping in stagnant, the feeling of fullness distending pain, heavy behind the dysentery, constipation, the expectorant vapour lock thoracic obstruction that stagnates, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.
Rhizoma Chuanxiong: suffering, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Spina Gleditsiae: suffering, temperature.Return liver, stomach warp.The detumescence poison holding, evacuation of pus, parasite killing.Be used for carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.
Bulbus Fritillariae Thunbergii: hardship, cold.Return lung, heart channel.The heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing is used for wind-heat invading the lung, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.
Folium Citri tangerinae: for the leaf of rutaceae orange Citrus reticulata Blanco, can adopt at any time, dry or using fresh herb.Hardship, flat.。Be used for mastitis, hypochondriac pain.
Fructus Psoraleae: hot, bitter, temperature.Return kidney, spleen channel.。Be used for impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness is suffered from a deficiency of the kidney and is done to breathe heavily, and has loose bowels just before dawn; The external curing vitiligo, alopecia areata.
Scolopendra: suffering, temperature; Poisonous.Return Liver Channel.。Be used for infantile convulsion, the tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
Wherein, the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can be preferably: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine is: Fructus Akebiae 20～45 weight portions, Rhizoma Cyperi 10～25 weight portions, Fructus Toosendan 20～35 weight portions, the Radix Aucklandiae 15～25 weight portions, Cortex Albiziae 15～25 weight portions, Radix Curcumae 20～30 weight portions, Sargassum 20～40 weight portions, Fructus Hordei Germinatus 25～40 weight portions, Radix Paeoniae Rubra 10～20 weight portions, Radix Bupleuri 10～25 weight portions, Fructus Aurantii 15～25 weight portions, Rhizoma Curcumae 10～30 weight portions, Pericarpium Citri Reticulatae Viride 10～15 weight portions, Fructus Aurantii Immaturus 15～35 weight portions, Rhizoma Chuanxiong 5～15 weight portions, Spina Gleditsiae 10～20 weight portions, Bulbus Fritillariae Thunbergii 15～30 weight portions, Folium Citri tangerinae 10～25 weight portions, Fructus Psoraleae 25～40 weight portions and Scolopendra 6～15 weight portions.
Wherein, the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine also can be preferably: Fructus Akebiae 20～35 weight portions, Rhizoma Cyperi 10～20 weight portions, Fructus Toosendan 20～30 weight portions, the Radix Aucklandiae 20～25 weight portions, Cortex Albiziae 15～20 weight portions, Radix Curcumae 25～30 weight portions, Sargassum 30～40 weight portions, Fructus Hordei Germinatus 25～30 weight portions, Radix Paeoniae Rubra 10～15 weight portions, Radix Bupleuri 15～25 weight portions, Fructus Aurantii 15～20 weight portions, Rhizoma Curcumae 20～30 weight portions, Pericarpium Citri Reticulatae Viride 10～12 weight portions, Fructus Aurantii Immaturus 15～25 weight portions, Rhizoma Chuanxiong 10～15 weight portions, Spina Gleditsiae 10～15 weight portions, Bulbus Fritillariae Thunbergii 20～30 weight portions, Folium Citri tangerinae 10～20 weight portions, Fructus Psoraleae 25～30 weight portions and Scolopendra 8～12 weight portions.
Wherein, the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine can also be preferably: Fructus Akebiae 30 weight portions, Rhizoma Cyperi 12 weight portions, Fructus Toosendan 25 weight portions, the Radix Aucklandiae 22 weight portions, Cortex Albiziae 18 weight portions, Radix Curcumae 25 weight portions, Sargassum 32 weight portions, Fructus Hordei Germinatus 28 weight portions, Radix Paeoniae Rubra 14 weight portions, Radix Bupleuri 20 weight portions, Fructus Aurantii 16 weight portions, Rhizoma Curcumae 25 weight portions, Pericarpium Citri Reticulatae Viride 12 weight portions, Fructus Aurantii Immaturus 20 weight portions, Rhizoma Chuanxiong 12 weight portions, Spina Gleditsiae 10 weight portions, Bulbus Fritillariae Thunbergii 30 weight portions, Folium Citri tangerinae 16 weight portions, Fructus Psoraleae 28 weight portions and Scolopendra 10 weight portions.
When the dosage form of described Chinese medicine was powder, its preparation method may further comprise the steps:
The first step is mixed in proportion described raw medicinal material, is ground into powder;
Second step obtained powder with the first step and adds in the cold water and soaked 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains first filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtains of the first step;
In the 3rd step, the filtering residue that second step filter was obtained adds in the cold water once more, with slow fire boiling 2 hours～4 hours, filters and obtains second filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtained in second step;
The 4th step, first filtrate of second step acquisition and second filtrate of the 3rd step acquisition are mixed, concentrating under reduced pressure removes and anhydrates, and drying is ground into powder, and granularity is 80～120 orders;
The 5th step in the powder that obtains in described the 4th step, added starch, and the percentage by weight of described starch in described powder is 15%～30%, and with pouch or packing box packing, per 5～10 grams are one bag or a box packing with the material behind the mixing.
When the dosage form of described Chinese medicine is an oral solutions, its preparation method may further comprise the steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, with determining alcohol is that 70%～80% methanol is as solvent, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that is added is 3～5 times of first step mixture quality;
Second step was mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, was ground into powder;
The 3rd step added the distilled water of 3～6 times of the powder qualities that obtain with respect to second step, decocted filtration 2～4 hours, obtain first filtrate,, decocted 1～2 hour the distilled water of filtering residue adding with respect to 2～4 times of its quality, filter, obtain second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, the adding determining alcohol is 90～95% ethanol, makes determining alcohol reach 70%～80%, left standstill 12～24 hours, and filtered concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;
In the 4th step, the powder mixes with second step and the acquisition of the 3rd step adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilization promptly obtains oral liquid.
The present invention provides a kind of above-mentioned prescription preparation method of Chinese medicine again, and the dosage form of described Chinese medicine is a powder, and it may further comprise the steps:
The first step is mixed in proportion described raw medicinal material, is ground into powder;
Second step obtained powder with the first step and adds in the cold water and soaked 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains first filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtains of the first step;
In the 3rd step, the filtering residue that second step filter was obtained adds in the cold water once more, with slow fire boiling 2 hours～4 hours, filters and obtains second filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtained in second step;
The 4th step, first filtrate of second step acquisition and second filtrate of the 3rd step acquisition are mixed, concentrating under reduced pressure removes and anhydrates, and drying is ground into powder, and granularity is 80～120 orders;
The 5th step in the powder that obtains in described the 4th step, added starch, and the percentage by weight of described starch in described powder is 15%～30%, and with pouch or packing box packing, per 5～10 grams are one bag or a box packing with the material behind the mixing.
The present invention provides a kind of above-mentioned prescription preparation method of Chinese medicine again, and the dosage form of described Chinese medicine is an oral solutions, and it may further comprise the steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, with determining alcohol is that 70%～80% methanol is as solvent, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that is added is 3～5 times of first step mixture quality;
Second step was mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, was ground into powder;
The 3rd step added the distilled water of 3～6 times of the powder qualities that obtain with respect to second step, decocted filtration 2～4 hours, obtain first filtrate,, decocted 1～2 hour the distilled water of filtering residue adding with respect to 2～4 times of its quality, filter, obtain second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, the adding determining alcohol is 90～95% ethanol, makes determining alcohol reach 70%～80%, left standstill 12～24 hours, and filtered concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;
In the 4th step, the powder mixes with second step and the acquisition of the 3rd step adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilization promptly obtains oral liquid.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
Embodiment 1: the powder 1 of the present invention's preparation
The weight of the various raw medicinal materials in the Chinese medicine is: Fructus Akebiae 30g, Rhizoma Cyperi 12g, Fructus Toosendan 25g, Radix Aucklandiae 22g, Cortex Albiziae 18g, Radix Curcumae 25g, Sargassum 32g, Fructus Hordei Germinatus 28g, Radix Paeoniae Rubra 14g, Radix Bupleuri 20g, Fructus Aurantii 16g, Rhizoma Curcumae 25g, Pericarpium Citri Reticulatae Viride 12g, Fructus Aurantii Immaturus 20g, Rhizoma Chuanxiong 12g, Spina Gleditsiae 10g, Bulbus Fritillariae Thunbergii 30g, Folium Citri tangerinae 16g, Fructus Psoraleae 28g and Scolopendra 10g;
Its preparation method may further comprise the steps:
The first step is mixed in proportion the above-mentioned raw materials medical material, is ground into powder;
Second step obtained powder with the first step and adds in the cold water and soaked 12 hours, and with slow fire boiling, decocting time is 3 hours, and decoction liquor is filtered, and obtains first filtrate, and the quality of the water that is added is 4 times of the powder quality that obtains of the first step;
In the 3rd step, the filtering residue that second step filter was obtained adds in the cold water once more, with slow fire boiling 3 hours, filters and obtains second filtrate, and the quality of the water that is added is 4 times of the powder quality that obtained in second step;
The 4th step, first filtrate of second step acquisition and second filtrate of the 3rd step acquisition are mixed, concentrating under reduced pressure removes and anhydrates, and drying is ground into powder, and granularity is 100 orders;
The 5th step in the powder of the 4th step acquisition, added starch, and the percentage by weight of starch in powder is 25%, and with the pouch packing of the material behind the mixing, per 10 grams are one bag.
Embodiment 2: the powder 2 of the present invention's preparation
The weight of the various raw medicinal materials in the Chinese medicine is: Fructus Akebiae 35g, Rhizoma Cyperi 18g, Fructus Toosendan 20g, Radix Aucklandiae 20g, Cortex Albiziae 20g, Radix Curcumae 28g, Sargassum 36g, Fructus Hordei Germinatus 25g, Radix Paeoniae Rubra 12g, Radix Bupleuri 25g, Fructus Aurantii 18g, Rhizoma Curcumae 22g, Pericarpium Citri Reticulatae Viride 11g, Fructus Aurantii Immaturus 15g, Rhizoma Chuanxiong 15g, Spina Gleditsiae 14g, Bulbus Fritillariae Thunbergii 25g, Folium Citri tangerinae 12g, Fructus Psoraleae 25g and Scolopendra 12g;
Its preparation method may further comprise the steps:
The first step is mixed in proportion the above-mentioned raw materials medical material, is ground into powder;
Second step obtained powder with the first step and adds in the cold water and soaked 10 hours, and with slow fire boiling, decocting time is 4 hours, and decoction liquor is filtered, and obtains first filtrate, and the quality of the water that is added is 4 times of the powder quality that obtains of the first step;
In the 3rd step, the filtering residue that second step filter was obtained adds in the cold water once more, with slow fire boiling 3 hours, filters and obtains second filtrate, and the quality of the water that is added is 3 times of the powder quality that obtained in second step;
The 4th step, first filtrate of second step acquisition and second filtrate of the 3rd step acquisition are mixed, concentrating under reduced pressure removes and anhydrates, and drying is ground into powder, and granularity is 120 orders;
The 5th step in the powder of the 4th step acquisition, added starch, and the percentage by weight of starch in powder is 20%, and with the pouch packing of the material behind the mixing, per 10 grams are one bag.
Embodiment 3: the oral solutions 1 of the present invention's preparation
The weight of the various raw medicinal materials in the Chinese medicine is: Fructus Akebiae 25g, Rhizoma Cyperi 13g, Fructus Toosendan 25g, Radix Aucklandiae 23g, Cortex Albiziae 20g, Radix Curcumae 30g, Sargassum 38g, Fructus Hordei Germinatus 26g, Radix Paeoniae Rubra 15g, Radix Bupleuri 22g, Fructus Aurantii 15g, Rhizoma Curcumae 26g, Pericarpium Citri Reticulatae Viride 10g, Fructus Aurantii Immaturus 23g, Rhizoma Chuanxiong 14g, Spina Gleditsiae 11g, Bulbus Fritillariae Thunbergii 29g, Folium Citri tangerinae 16g, Fructus Psoraleae 27g and Scolopendra 11g;
Its preparation method may further comprise the steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, with determining alcohol is that 80% methanol is as solvent, adopt percolation with the speed of per minute 2ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that is added is 4 times of first step mixture quality;
Second step was mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, was ground into powder;
The 3rd step added the distilled water of 5 times of the powder qualities that obtain with respect to second step, decocted filtration 3 hours, obtain first filtrate,, decocted 2 hours the distilled water of filtering residue adding with respect to 3 times of its quality, filter, obtain second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, the adding determining alcohol is 95% ethanol, makes determining alcohol reach 70%～80%, left standstill 24 hours, and filtered concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;
In the 4th step, the powder mixes with second step and the acquisition of the 3rd step adds the distilled water with respect to 4 times of amounts of powder quality, 0.2 times sucrose, and 0.01 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilization promptly obtains oral liquid.
Embodiment 4: the oral solutions 2 of the present invention's preparation
The weight of the various raw medicinal materials in the Chinese medicine is: Fructus Akebiae 40g, Rhizoma Cyperi 22g, Fructus Toosendan 22g, Radix Aucklandiae 17g, Cortex Albiziae 23g, Radix Curcumae 27g, Sargassum 36g, Fructus Hordei Germinatus 34g, Radix Paeoniae Rubra 18g, Radix Bupleuri 24g, Fructus Aurantii 23g, Rhizoma Curcumae 14g, Pericarpium Citri Reticulatae Viride 14g, Fructus Aurantii Immaturus 31g, Rhizoma Chuanxiong 9g, Spina Gleditsiae 16g, Bulbus Fritillariae Thunbergii 24g, Folium Citri tangerinae 22g, Fructus Psoraleae 36g and Scolopendra 14g;
Its preparation method may further comprise the steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, with determining alcohol is that 75% methanol is as solvent, adopt percolation with the speed of per minute 1ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that is added is 5 times of first step mixture quality;
Second step was mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, was ground into powder;
The 3rd step added the distilled water of 4 times of the powder qualities that obtain with respect to second step, decocted filtration 2 hours, obtain first filtrate,, decocted 1.5 hours the distilled water of filtering residue adding with respect to 3 times of its quality, filter, obtain second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, the adding determining alcohol is 90% ethanol, makes determining alcohol reach 70%～80%, left standstill 18 hours, and filtered concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;
In the 4th step, the powder mixes with second step and the acquisition of the 3rd step adds the distilled water with respect to 3 times of amounts of powder quality, 0.1 times sucrose, and 0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilization promptly obtains oral liquid.
Acute toxicity test
With the powder 1 of the embodiment of the invention 1 preparation, the powder 2 of embodiment 2 preparations, the oral solutions 1 of embodiment 3 preparations and the oral solutions 2 of embodiment 4 preparations, powder 1 and powder 2 are dissolved in the distilled water respectively, give 4 groups of white mice feedings dispensings respectively with 140 times, 200 times, 160 times of clinical consumption per day and 220 times, observed 7; All white mice are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, do not see toxic reaction.Irritation test is carried out in white mouse oral cavity and damaged skin, and not seeing has irritative response and other untoward reaction.
Long term toxicity test
Powder 1 with the embodiment of the invention 1 preparation, 2 pairs of mices of powder of embodiment 2 preparations are by 7.81,18.34 and 40.11g crude drug/kg is dissolved in the water, the oral solutions 1 of the embodiment of the invention 3 preparations and 2 pairs of mices of oral solutions of embodiment 4 preparations are pressed 8.15,19.25 and 40.34g crude drug/kg, to 4 groups of mices difference 12 weeks of continuous use, every day 2 times, and after 4 weeks of drug withdrawal, the result shows: Chinese medicine of the present invention is to the hair of 4 groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, indexs such as blood fat all do not have obvious influence, the internal organs naked eyes do not find that difference changes and the histological examination result shows, after 12 weeks of medication and 4 weeks of drug withdrawal, each internal organs of mice all do not have obvious change.Illustrate that toxicity is little after Chinese medicine of the present invention is to the mice long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.
Clinical data:
Select outpatient's 127 examples of liver energy stagnation type cyclomastopathy, be divided into two treatment groups and two matched groups according to the random table method.
One 37 examples are organized in treatment, 24～49 years old age, average 35 years old; The course of disease 5 months～6 years, one-sided breast 17 examples of falling ill, bilateral breast 20 examples of falling ill;
2 33 examples are organized in treatment, 22～48 years old age, average 34 years old; The course of disease 4 months～5 years, one-sided breast 14 examples of falling ill, bilateral breast 19 examples of falling ill;
Matched group one 29 examples, 22～50 years old age, average 36 years old, the course of disease 3 months～6 years, one-sided breast 13 examples of falling ill, bilateral breast 16 examples of falling ill;
Matched group 2 28 examples, 20～52 years old age, average 36 years old, the course of disease 6 months～7 years, one-sided breast 14 examples of falling ill, bilateral breast 14 examples of falling ill;
It is similar substantially that four groups of data distribute on age, the course of disease, the state of an illness, has comparability.
Diagnostic criteria is with reference to the diagnostic criteria of " surgery " cyclomastopathy: 1) pain appears in one-sided or bilateral breast, and majority has periodically, and it is relevant with menstrual cycle to show effect, and menstruation a few days ago pain increases the weight of, and alleviates behind the menstrual onset or disappears; 2) side or bilateral breast body of gland limitation or diffuse thickening are found in health check-up, and lump is graininess, and is not of uniform size, and matter is tough and not hard, and buildup area is unclear with normal galactophore tissue's boundary on every side; 3) the primary disease course of disease is longer, slower development, good sending out in middle-aged women; 4) small number of patients can be associated with nipple discharge, for serosity or slurry courage and uprightness, if any above-mentioned two above persons, can confirm as primary disease.Utilize auxiliary detection means such as molybdenum target x line, B ultrasonic, thermal image figure in case of necessity, or pin suction cytolgical examination of row lump and local living tissue pathologic finding, to get rid of other good, malignant disease such as breast carcinoma, mammary gland fibroma.
Criterion of therapeutical effect is drafted according to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " that the State Administration of Traditional Chinese Medicines works out.Clinical cure: pain and lump all disappear, and nipple does not have discharge and keeps 6 months persons; Produce effects: pain disappears, and the lump that thickens softens and scatters, and lump dwindles greater than 50%; Effectively: pain is obviously alleviated, the lump deliquescing, and lump dwindles less than 50%; Invalid: pain does not have alleviation, and lump size, quality do not have change.
Therapeutic Method:
The powder agent medicine of an oral embodiment of the invention 1 is organized in treatment, and morning every day, evening are respectively taken each 2 bags 1 time.One month is a course of treatment, takes 2 courses of treatment.Period in a medicine fasting raw food, irritable food such as greasy, pungent.
The oral solutions medicine of the two oral embodiment of the invention 4 is organized in treatment, and morning every day, evening respectively take 1 time, each 15ml.One month is a course of treatment, takes 2 courses of treatment.Fasting raw food during applying medicinal lotion or ointment, irritable food such as greasy, pungent.
Matched group one is taken 5% potassium iodide, and every day 3 times is oral, each 10ml, and 2 months is 1 course of treatment, takes 1 course of treatment.
Matched group two is taken the Chinese patent medicine ease pill, and every day 2 times is oral, and each 10,1 month is 1 course of treatment, takes 2 courses of treatment.Period in a medicine fasting raw food, irritable food such as greasy, pungent.
Therapeutic outcome:
One 37 examples are organized in treatment, clinical cure 27 examples (73%), produce effects 5 examples (13.5%), effective 4 examples (10.8%), invalid 1 example (2.7%), total effective rate 97.3%; Check in 3-6 month does not have recurrence after the drug withdrawal.
2 33 examples are organized in treatment, clinical cure 23 examples (69.7%), produce effects 4 examples (12.1%), effective 6 examples (15.2%), invalid 1 example (3%), total effective rate 97%; Check in 3-6 month does not have recurrence after the drug withdrawal.
Matched group one 29 examples, clinical cure 10 examples (34.5%), produce effects 5 examples (17.2%), effective 7 examples (24.1%), invalid 7 examples (24.1%), total effective rate 75.9%; Check in 3-6 month is recurred 6 people, relapse rate 20.1% after the drug withdrawal.
Matched group 2 28 examples, clinical cure 12 examples (42.9%), produce effects 7 examples (25%), effective 5 examples (17.9%), invalid 4 examples (14.3%), total effective rate 85.7%; Check in 3-6 month is recurred 4 people, relapse rate 14.3% after the drug withdrawal.
Analyze through Ridit, treatment group curative effect is better than matched group (P＜0.05), promptly adopts Chinese medicine of the present invention to treat, and its curative effect will be significantly better than matched group, and is difficult for recurrence.
In addition, the example of 27 in the treatment group one is cured among the patient, and 16 examples were cured in 1 month, and 11 examples were cured in 2nd month;
In the treatment group two 23 example is cured among the patient, and 14 examples were cured in 1 month, and 9 examples were cured in 2nd month;
In the matched group one 10 example is cured among the patient, and 3 examples were cured in 1 month, and 7 examples were cured in 2nd month;
In the matched group two 12 example is cured among the patient, and 5 examples were cured in 1 month, and 7 examples were cured in 2nd month.
By foregoing as can be known, adopt Chinese medicine of the present invention to treat, its treatment time will be significantly shorter than the treatment time of matched group, and it is shorter promptly to treat the course of treatment.
Model case:
Mrs Zhao, 29 years old.Found two breasts enclosed mass lump that all differs in size before patient's readme half a year, come two mammary swellings pains of the time of tide at each menstrual cycle, and enclosed mass has increase, through back pain disappearance, but enclosed mass only dwindles.When excited, when angry especially then distending pain of the breast more very, irritability.The outer quadrant of the left and right breast enclosed mass that all differs in size, hard in the matter, smooth surface, mobility is good, and tenderness is obvious.Bilateral breast skin is normal, and nipple does not have depression and discharge.Ultrasound diagnosis: bilateral breast lobule fibroid hypertrophy.Ru Fang Molybdenum target X ray examination: two cyclomastopathy.The gonadal hormone inspection is unusual.Diagnosis: cyclomastopathy.Be judged to be the liver energy stagnation type cyclomastopathy that the traditional Chinese medical science is thought, take the powder of the embodiment of the invention 1, morning every day, evening respectively take 1 time, each 2 bags, mixing in water for oral taking, the 2 all rear udder attachment pain reliefs of taking medicine, it is comparatively steady that emotion becomes, 4 all rear udder attachment pain and menstrual period distending pain obviously alleviate, anxious state of mind and body of the tongue take a favorable turn, and continue to take to 7 weeks, two swelling of the breast pieces and menstrual period pain all disappear,, the B ultrasonic body of gland is clear, and the gonadal hormone inspection is normal, all the other all diseases all disappear or are clearly better, after continuing to take 1 week, all transference cures are followed up a case by regular visits to not recurrence in 1 year.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment did, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (8)
1. Chinese medicine for the treatment of the liver energy stagnation type cyclomastopathy, it is characterized in that, comprise following raw medicinal material in the described Chinese medicine: Fructus Akebiae, Rhizoma Cyperi, Fructus Toosendan, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Sargassum, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii Immaturus, Rhizoma Chuanxiong, Spina Gleditsiae, Bulbus Fritillariae Thunbergii, Folium Citri tangerinae, Fructus Psoraleae and Scolopendra.
2. Chinese medicine according to claim 1, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine is: Fructus Akebiae 20～45 weight portions, Rhizoma Cyperi 10～25 weight portions, Fructus Toosendan 20～35 weight portions, the Radix Aucklandiae 15～25 weight portions, Cortex Albiziae 15～25 weight portions, Radix Curcumae 20～30 weight portions, Sargassum 20～40 weight portions, Fructus Hordei Germinatus 25～40 weight portions, Radix Paeoniae Rubra 10～20 weight portions, Radix Bupleuri 10～25 weight portions, Fructus Aurantii 15～25 weight portions, Rhizoma Curcumae 10～30 weight portions, Pericarpium Citri Reticulatae Viride 10～15 weight portions, Fructus Aurantii Immaturus 15～35 weight portions, Rhizoma Chuanxiong 5～15 weight portions, Spina Gleditsiae 10～20 weight portions, Bulbus Fritillariae Thunbergii 15～30 weight portions, Folium Citri tangerinae 10～25 weight portions, Fructus Psoraleae 25～40 weight portions and Scolopendra 6～15 weight portions.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine is: Fructus Akebiae 20～35 weight portions, Rhizoma Cyperi 10～20 weight portions, Fructus Toosendan 20～30 weight portions, the Radix Aucklandiae 20～25 weight portions, Cortex Albiziae 15～20 weight portions, Radix Curcumae 25～30 weight portions, Sargassum 30～40 weight portions, Fructus Hordei Germinatus 25～30 weight portions, Radix Paeoniae Rubra 10～15 weight portions, Radix Bupleuri 15～25 weight portions, Fructus Aurantii 15～20 weight portions, Rhizoma Curcumae 20～30 weight portions, Pericarpium Citri Reticulatae Viride 10～12 weight portions, Fructus Aurantii Immaturus 15～25 weight portions, Rhizoma Chuanxiong 10～15 weight portions, Spina Gleditsiae 10～15 weight portions, Bulbus Fritillariae Thunbergii 20～30 weight portions, Folium Citri tangerinae 10～20 weight portions, Fructus Psoraleae 25～30 weight portions and Scolopendra 8～12 weight portions.
4. as Chinese medicine as described in the claim 1 to 3, it is characterized in that: the ratio of weight and number of the various raw medicinal materials in the described Chinese medicine is: Fructus Akebiae 30 weight portions, Rhizoma Cyperi 12 weight portions, Fructus Toosendan 25 weight portions, the Radix Aucklandiae 22 weight portions, Cortex Albiziae 18 weight portions, Radix Curcumae 25 weight portions, Sargassum 32 weight portions, Fructus Hordei Germinatus 28 weight portions, Radix Paeoniae Rubra 14 weight portions, Radix Bupleuri 20 weight portions, Fructus Aurantii 16 weight portions, Rhizoma Curcumae 25 weight portions, Pericarpium Citri Reticulatae Viride 12 weight portions, Fructus Aurantii Immaturus 20 weight portions, Rhizoma Chuanxiong 12 weight portions, Spina Gleditsiae 10 weight portions, Bulbus Fritillariae Thunbergii 30 weight portions, Folium Citri tangerinae 16 weight portions, Fructus Psoraleae 28 weight portions and Scolopendra 10 weight portions.
5. as Chinese medicine as described in the claim 1 to 4, it is characterized in that when the dosage form of described Chinese medicine was powder, its preparation method may further comprise the steps:
The first step is mixed in proportion described raw medicinal material, is ground into powder;
Second step obtained powder with the first step and adds in the cold water and soaked 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains first filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtains of the first step;
In the 3rd step, the filtering residue that second step filter was obtained adds in the cold water once more, with slow fire boiling 2 hours～4 hours, filters and obtains second filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtained in second step;
The 4th step, first filtrate of second step acquisition and second filtrate of the 3rd step acquisition are mixed, concentrating under reduced pressure removes and anhydrates, and drying is ground into powder, and granularity is 80～120 orders;
The 5th step in the powder that obtains in described the 4th step, added starch, and the percentage by weight of described starch in described powder is 15%～30%, and with pouch or packing box packing, per 5～10 grams are one bag or a box packing with the material behind the mixing.
6. as Chinese medicine as described in the claim 1 to 4, it is characterized in that: when the dosage form of described Chinese medicine is an oral solutions, its preparation method may further comprise the steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, with determining alcohol is that 70%～80% methanol is as solvent, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that is added is 3～5 times of first step mixture quality;
Second step was mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, was ground into powder;
The 3rd step added the distilled water of 3～6 times of the powder qualities that obtain with respect to second step, decocted filtration 2～4 hours, obtain first filtrate,, decocted 1～2 hour the distilled water of filtering residue adding with respect to 2～4 times of its quality, filter, obtain second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, the adding determining alcohol is 90～95% ethanol, makes determining alcohol reach 70%～80%, left standstill 12～24 hours, and filtered concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;
In the 4th step, the powder mixes with second step and the acquisition of the 3rd step adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilization promptly obtains oral liquid.
7. as preparation method of Chinese medicine as described in the claim 1 to 4, it is characterized in that: the dosage form of described Chinese medicine is a powder, and it may further comprise the steps:
The first step is mixed in proportion described raw medicinal material, is ground into powder;
Second step obtained powder with the first step and adds in the cold water and soaked 6 hours～12 hours, and with slow fire boiling, decocting time is 3 hours～5 hours, and decoction liquor is filtered, and obtains first filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtains of the first step;
In the 3rd step, the filtering residue that second step filter was obtained adds in the cold water once more, with slow fire boiling 2 hours～4 hours, filters and obtains second filtrate, and the quality of the water that is added is 2～4 times of the powder quality that obtained in second step;
The 4th step, first filtrate of second step acquisition and second filtrate of the 3rd step acquisition are mixed, concentrating under reduced pressure removes and anhydrates, and drying is ground into powder, and granularity is 80～120 orders;
The 5th step in the powder that obtains in described the 4th step, added starch, and the percentage by weight of described starch in described powder is 15%～30%, and with pouch or packing box packing, per 5～10 grams are one bag or a box packing with the material behind the mixing.
8. as preparation method of Chinese medicine as described in the claim 1 to 4, it is characterized in that: the dosage form of described Chinese medicine is an oral solutions, and it may further comprise the steps:
The first step, Fructus Akebiae, Rhizoma Cyperi, the Radix Aucklandiae, Cortex Albiziae, Radix Curcumae, Fructus Hordei Germinatus, Radix Paeoniae Rubra, Radix Bupleuri, Fructus Aurantii, Fructus Aurantii Immaturus and Rhizoma Chuanxiong are mixed in proportion, with determining alcohol is that 70%～80% methanol is as solvent, adopt percolation with the speed of per minute 1～3ml percolation slowly, collect percolate, concentrating under reduced pressure is also dry, obtains to get dry extract, be ground into powder, the quality of the methanol that is added is 3～5 times of first step mixture quality;
Second step was mixed in proportion Fructus Toosendan, Folium Citri tangerinae, Spina Gleditsiae, Sargassum, Bulbus Fritillariae Thunbergii, Rhizoma Curcumae, Pericarpium Citri Reticulatae Viride, Fructus Psoraleae and Scolopendra, was ground into powder;
The 3rd step added the distilled water of 3～6 times of the powder qualities that obtain with respect to second step, decocted filtration 2～4 hours, obtain first filtrate,, decocted 1～2 hour the distilled water of filtering residue adding with respect to 2～4 times of its quality, filter, obtain second filtrate, merge filtrate, concentrate away the water of 2/3～3/4 volume, the adding determining alcohol is 90～95% ethanol, makes determining alcohol reach 70%～80%, left standstill 12～24 hours, and filtered concentrating under reduced pressure, drying obtains and gets dry extract, and is ground into powder;
In the 4th step, the powder mixes with second step and the acquisition of the 3rd step adds the distilled water with respect to 3～5 times of amounts of powder quality, 0.1～0.3 times sucrose, and 0.01～0.02 times sodium benzoate stirs, and boils, and cooling is filtered, packing, sterilization promptly obtains oral liquid.
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| CN105726915A (en) * | 2016-04-27 | 2016-07-06 | 郑耀玲 | Traditional Chinese medicine composition for treating liver-qi stagnation type mastitis |
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| CN101732528A (en) * | 2010-02-10 | 2010-06-16 | 李蕴 | Chinese medicament for treating of hyperplasia of mammary gland |
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| CN102949631A (en) * | 2012-11-08 | 2013-03-06 | 王玉青 | Traditional prescription for treating mammary gland hyperplasia |
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| CN101732528A (en) * | 2010-02-10 | 2010-06-16 | 李蕴 | Chinese medicament for treating of hyperplasia of mammary gland |
| CN102716417A (en) * | 2012-06-15 | 2012-10-10 | 祁连明 | Traditional Chinese medicine preparation for treating gynaecopathia and preparation method of preparation |
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| CN104258219A (en) * | 2014-09-10 | 2015-01-07 | 王力力 | Traditional Chinese medicine decoction for treating hyperplasia of mammary glands |
| CN105726915A (en) * | 2016-04-27 | 2016-07-06 | 郑耀玲 | Traditional Chinese medicine composition for treating liver-qi stagnation type mastitis |
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