CN102772585B - Medicinal composition for treating appendicitis as well as preparation method and application thereof - Google Patents

Abstract

The invention discloses a medicinal composition for treating appendicitis, which is a preparation prepared from the following bulk drugs in parts by weight: 8-16 parts of rheum officinale, 5-11 parts of mirabilite, 8-16 parts of peach seed, 8-16 parts of tree peony bark, 10-20 parts of mangnolia officinalis, 8-16 parts of immature bitter orange, 21-39 parts of white gourd kernel, 7-13 parts of radix angelicae, 21-39 parts of sargent gloryvine, 21-39 parts of patrinia scaniosaefolia and 21-39 parts of herba violae. The invention also discloses a preparation method and application of the medicinal composition. The medicinal composition disclosed by the invention can effectively eliminate or greatly relieve acute attack of various acute appendicitis and chronic appendicitis, has a certain healing effect on appendicitis, dispenses with appendectomy for patients, has no obvious toxic or side effect, and is a new, safe and effective medicine for clinically treating appendicitis.

Description

A kind of typhlitic pharmaceutical composition and its production and use for the treatment of

Technical field

The present invention relates to a kind of typhlitic pharmaceutical composition and its production and use for the treatment of.

Background technology

Appendicitis, refers to that vermiform appendix is because the inflammatory that many factors forms changes, Abdominal Surgery.It is a kind of commonly encountered diseases, and whether its prognosis is depended on and diagnosed timely and treat.Early stage diagnosis and treatment, the many rehabilitations in a short time of patient, mortality rate is 0.1%-0.2%; If delay diagnosis and treatment can cause serious complication, even cause death.Often there are clinically the performances such as right lower abdomen pain, fervescence, vomiting and neutrophilic leukocytosis.How appendicitis is divided into acute appendicitis and chronic appendicitis at present.

The typical clinical performance of acute appendicitis be epigastrium or umbilicus around gradually significantly or the dull pain increasing the weight of, after a few hours, stomachache is transferred to right lower abdomen.Often with inappetence, n or V, their early stage except low grade fever, weak, many without obvious General Symptoms.Chronic appendicitis refers to the vermiform appendix chronic inflammatory disease pathological changes of leaving over after vermiform appendix acute inflammation subsides, such as tube wall fibrous connective tissue hypertrophy, luminal stenosis or obturation, torsion of appendix, with surrounding tissue adhesion etc.Chronic appendicitis can be negligent of the various complicated reason acute attacks such as conditioning because of malpractice, environmental factors, patient self.

Doctor trained in Western medicine generally all advocates to implement appendectomy to appendicitis.Yet, the result of study that contemporary science constantly manifests, especially modern immunologic progress is thought: vermiform appendix has abundant lymphoid tissue, participates in the immunologic function of body.According to its research, mankind's vermiform appendix has bone-marrow-derived lymphocyte and T lymphocyte, is equivalent to the bursa of Fabricius's of birds structure, and central immune organ is due to being undertaken cellular immunization and the large exceptional function of humoral immunization two of body.Its newest research results also confirms, vermiform appendix still has secretory cell, can secrete many kinds of substance and digestive enzyme, the hormone that impels intestinal tube hyperperistalsis and the hormone relevant with growth etc.In addition, the development of spare-part surgery, the doctor of Ye Gei Clinical Surgery prompting: vermiform appendix has complete interior circular muscle and outer longitudinal muscle, there are certain length and caliber, development along with microsurgery, utilize autologous some pipeline of vermiform appendix transplantation substitute as increasingly extensive in the damaged and narrow operation of ureter, urethra, therefore should strictly grasp indication and the crowd of appendectomy, to subsidiary appendectomy, more will hold very prudent attitude.

China is used the outbreak of Chinese medicinal formulae treatment appendicitis, has had the accumulation of 2,000 years above mature experiences and a large amount of side's medicine, case.In order to avoid appendectomy as far as possible, from Chinese traditional treatment, start with, find the medicine of effectively treating acute appendicitis or chronic appendicitis acute epilepsy, seem particularly necessary.

Summary of the invention

The object of the present invention is to provide the pharmaceutical composition of a kind of effective treatment acute appendicitis or chronic appendicitis acute epilepsy.Another object of the present invention is to provide preparation method and the purposes of this pharmaceutical composition.

The invention provides a kind of typhlitic pharmaceutical composition for the treatment of, it is the preparation that the crude drug by following weight proportion is prepared from:

8 ~ 16 parts of Radix Et Rhizoma Rhei, 5 ~ 11 parts, Natrii Sulfas, 8 ~ 16 parts, Semen Persicae, 8 ~ 16 parts of Cortex Moutans, 10 ~ 20 parts of Cortex Magnoliae Officinalis, 8 ~ 16 parts of Fructus Aurantii Immaturuss, 21 ~ 39 parts of Semen Benincasaes, 7 ~ 13 parts of the Radixs Angelicae Dahuricae, 21 ~ 39 parts of Caulis Sargentodoxaes, 21 ~ 39 parts of Herba Patriniaes, 21 ~ 39 parts of Herba Violaes.

Further, it is the preparation that the crude drug by following weight proportion is prepared from:

10 ~ 14 parts of Radix Et Rhizoma Rhei, 6 ~ 10 parts, Natrii Sulfas, 10 ~ 14 parts, Semen Persicae, 10 ~ 14 parts of Cortex Moutans, 13 ~ 17 parts of Cortex Magnoliae Officinalis, 10 ~ 14 parts of Fructus Aurantii Immaturuss, 26 ~ 34 parts of Semen Benincasaes, 8 ~ 12 parts of the Radixs Angelicae Dahuricae, 26 ~ 34 parts of Caulis Sargentodoxaes, 26 ~ 34 parts of Herba Patriniaes, 26 ~ 34 parts of Herba Violaes.

Further preferably, it is the preparation that the crude drug by following weight proportion is prepared from:

12 parts of Radix Et Rhizoma Rhei, 8 parts, Natrii Sulfas, 12 parts, Semen Persicae, 12 parts of Cortex Moutans, 15 parts of Cortex Magnoliae Officinalis, 12 parts of Fructus Aurantii Immaturuss, 30 parts of Semen Benincasaes, 10 parts of the Radixs Angelicae Dahuricae, 30 parts of Caulis Sargentodoxaes, 30 parts of Herba Patriniaes, 30 parts of Herba Violaes.

Wherein, described Radix Et Rhizoma Rhei is Radix et Rhizoma Rhei (processed with wine).

Wherein, described preparation is oral formulations.

Further, described oral formulations is oral liquid, capsule, tablet, granule, powder or pill.

Further, described oral formulations is drop pill or soft capsule.

The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises the steps:

(1) by proportioning weighting raw materials;

(2) get other crude drug except Radix Et Rhizoma Rhei, Natrii Sulfas, after decocting with water, rear lower Radix Et Rhizoma Rhei, after having decocted, merges decocting liquid, then adds Natrii Sulfas, by pharmaceutically conventional method, is prepared into common dosage forms.

The present invention also provides the purposes of aforementioned pharmaceutical compositions in the medicine of preparation treatment acute appendicitis or chronic appendicitis acute epilepsy.

Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the most scientific the most several large advantages of the traditional Chinese medical science, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arrayed troops for battle in traditional Chinese medical science prescription is its effective means that is better than Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism regulating, to acute appendicitis and chronic appendicitis acute epilepsy bear down menacingly like this, the disease of hurt like hell regulates and controls, can obtain better than Western medicine, more comprehensively, therapeutic effect more thoroughly, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, prescription of the present invention is just being followed this principle.

In traditional Chinese medical science traditional theory, acute appendicitis and chronic appendicitis acute epilepsy belong to the FU QI being obstructed in traditional Chinese medical science internal organs theory, control when falling internal organs gas for greatly to lead to, and the concrete rule for the treatment of is foul for washing away, lead to and falls internal organs gas, promoting the circulation of blood removing blood stasis, all methods of heat-clearing and toxic substances removing in conjunction with utilization.In Traditional Chinese Medicine yin-yang theory and internal organs meridian theory, dirty genus " clearly " is sun, it is cloudy that internal organs belongs to " turbid ", vermiform appendix is subordinate to the internal organs of large intestine, admittedly be " ground of turbid yin ", the heresy that very easily causes water paddy instituteization waste matter in large intestine is offended, and it is stagnant to cause the foul heresy of waste matter, the heat-dissipating of accumulating in the course of time, " heat " is very " fire " (two " fire " are doctor trained in Western medicine it " inflammation "), burning hot sufferer affect normal physiological function, and normally mechanism of qi is obstructed, therefore the stagnation of QI and blood stasis, blood stasis is congestive edema, congestive edema fire (inflammation) is more very vehement, and vehement very congestive edema further, forms vicious cycle.On the other hand, the traditional Chinese medical science has a well-known saying " stagnation of QI and blood may bring about pain, pain is obstructed ", otherwise " general rule is not bitterly ".Affected part congestive edema red-hot (inflammation), therefore alluvial is obstructed, and obstructed event pain, so patient's pain is hard to bear.

In pharmaceutical composition of the present invention, take Radix Et Rhizoma Rhei, Natrii Sulfas is monarch, washes away intestinal internal organs foul, directly drives primary symptom (the strong patient of the disease that minority is extremely heavy can use Radix Et Rhizoma Rhei, and generally all uses Radix et Rhizoma Rhei (processed with wine)).Because causing, congestive edema (inflammation) has an intense pain, therefore blood circulation promoting and blood stasis dispelling is also a urgent ring, therefore in pharmaceutical composition of the present invention, with Semen Persicae, Cortex Moutan, serve as ministerial drug, promoting blood circulation and cooling blood repercussive, solve second largest problem outside monarch drug effect (the Radix Et Rhizoma Rhei effect of also invigorating blood circulation is used in we the also merit of receipts double gain).Theory of Chinese medical science thinks " qi being the governor of blood " to only have gas capable, and blood could move better; In addition, it is dirty that the " RUN " effect of the medicine of circulation of qi promoting also can help Radix Et Rhizoma Rhei, Natrii Sulfas is cleansed internal organs, therefore assist a ruler in governing a country Semen Persicae, the Cortex Moutan logical stasis of blood of invigorating blood circulation better with the product that two kinds of Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus are arrogated to oneself circulation of qi promoting most, assist a ruler in governing a country Radix Et Rhizoma Rhei, Natrii Sulfas and cleanse better the filth in intestinal internal organs, be one group of adjuvant drug for " Road ".Semen Benincasae, the Radix Angelicae Dahuricae have the effect of evacuation of pus, therefore assist Radix Et Rhizoma Rhei, Natrii Sulfas to wash dirty evacuation of pus with it; In addition, traditional Chinese medical science internal organs theory is also thought " the lung and the large intestine being interior-exteriorly related ", open lung qi dispersing gas and can make intestinal internal organs more unobstructed, and the Radix Angelicae Dahuricae is except evacuation of pus, just has the effect of lung qi dispersing, therefore be used in we also for killing two birds with one stone.Semen Benincasae, the Radix Angelicae Dahuricae are " left road " one group of adjuvant drug.Appendicitis also claims " acute appendicitis " in the traditional Chinese medical science, suitable heat-clearing and toxic substances removing is with subduing inflammation, and the product of Effect of Chinese Medicine Qing thermal detoxification are numerous, must select the most applicable, the most effective two or three good merchantable brands be use, and two kinds of Caulis Sargentodoxaes, Herba Patriniae are the first-selected kinds of doctor in 1,100 the most applicable treatment acute appendicitis of generally acknowledging, Caulis Sargentodoxae be more longer than be used in firm one-tenth soon and pus few in, Herba Patriniae be more longer than be used in formed pus or pus a lot of after, the two shares with choosing, complements each other, and pus does not become Cheng Jun to have special effect.Herba Violae and Herba Taraxaci are also the quality goods of heat-clearing and toxic substances removing eliminating carbuncle, but it is swollen that Herba Taraxaci is longer than the inflammation that the training the body body first half divides, Herba Violae is longer than and is treated inflammation that the health first half divides and swell, therefore select Herba Violae, serving as clearing heat, releasing toxin, removing swelling (antiinflammatory) important task together with Caulis Sargentodoxae, Herba Patriniae, is to be " right wing " another group adjuvant drug.Above three road adjuvant drugs, assist a ruler in governing a country principal agent, inferior principal agent (the monarch and his subjects) from different perspectives, " deploy forces " and have more reasonability, science, effectiveness in the side of making, and greatly strengthen the curative effect of pharmaceutical composition of the present invention.

In Chinese medicinal formulae, medicine is generally served as with Radix Glycyrrhizae, Fructus Jujubae or Rhizoma Zingiberis Recens and so on.But Radix Glycyrrhizae, Fructus Jujubae have the effect of " delaying ", the primary disease oncoming force is fierce anxious, treatment driving under also should pressing with the gesture of thunderclap thousand an ancient unit of weight swing it, therefore do not select the Radix Glycyrrhizae, Fructus Jujubae of " easing up " for making.Rhizoma Zingiberis Recens acrid in the mouth is hot in nature, is used in the primary disease of the hot fiery stasis of blood more non-institute suitable, therefore also do not select.

Various acute appendicitiss and chronic appendicitis acute epilepsy can effectively be eliminated or greatly alleviate to pharmaceutical composition of the present invention, appendicitis is had to certain healing effect, can allow patient exempt appendectomy, and, this pharmaceutical composition is without obvious toxic-side effects, for clinical treatment appendicitis provides a kind of safe and effective novel drugs.

The specific embodiment

The preparation of embodiment 1 pharmaceutical composition of the present invention

Get 12 grams of Radix et Rhizoma Rhei (processed with wine), 8 grams, Natrii Sulfas, 12 grams, Semen Persicae, 12 grams of Cortex Moutans, 15 grams of Cortex Magnoliae Officinalis, 12 grams of Fructus Aurantii Immaturuss, 30 grams of Semen Benincasaes, 10 grams of the Radixs Angelicae Dahuricae, 30 grams of Caulis Sargentodoxaes, 30 grams of Herba Patriniaes, 30 grams of Herba Violaes;

Each flavour of a drug take according to quantity, and Radix Et Rhizoma Rhei, Natrii Sulfas separately wrap, and Natrii Sulfas is ground as superfine end.After Semen Persicae peeling point, still protect the dosage of 12 grams of parts of foot, break.Mix with enough water purification, intense fire other kinds except Radix Et Rhizoma Rhei, Natrii Sulfas of being decocted first, change slow fire and decoct about 20 minutes again after boiling, the lower Radix Et Rhizoma Rhei that continues, then decoct 5 minutes～8 minutes, obtain.Natrii Sulfas powder is divided into 3 parts～6 parts, the medicinal liquid of decocting in order to take after mixing it with water.

Pharmaceutical composition of the present invention, takes once for 4 hours～6 hours.The strong person of seriously ill or body, medicinal liquid and Natrii Sulfas all take for 3 times, can within every 4 hours, just take once.Slow weak or the old or weakling of disease, can take the circumstances into consideration to take once for 5 hours or 6 hours, and medicinal liquid and Natrii Sulfas are divided into 5 times or 6 times and take after mixing it with water.Within 12 years old, above patient can take by the slow adult's instructions about how to take medicine weak or old or weakling of disease; 7 years old～11 years old child reduces by half and takes, and below 6 years old, within 3 years old, takes the circumstances into consideration above to take 1/3rd or 1/4th; Within 2 years old, more subtract below.Appendicitis borer is not suitable for pharmaceutical composition of the present invention.

Semen Benincasae described in the present invention, has another name called Semen Benincasae, is the seed of Cucurbitaceae Benincasa plant Fructus Benincasae Benincasa hispida (THunb.) Cogn.;

Caulis Sargentodoxae, has another name called Caulis Sargentodoxae, is the dry rattan of plants of Lardizabalaceae Sargentodoxa cuneata (Oliv.) Rehd.et Wils.;

Herba Patriniae is Valerianaceae plant Patrinia scabiosaefolia Fisch Patrinia scabiosae folia Fisch.exTrev. and patrima villosa P.villosa (Thunb.) Juss.[Valeriana villosa Thunb.] herb.

The preparation of embodiment 2 pharmaceutical compositions of the present invention

With embodiment 1, only Radix et Rhizoma Rhei (processed with wine) is made into, with Radix Et Rhizoma Rhei, by embodiment 1, to be prepared into medicinal liquid.Owing to using raw product Radix Et Rhizoma Rhei, its efficacy of a drug is more specially violent, the extremely heavy or athletic patient for the minority state of an illness.

The preparation of embodiment 3 pharmaceutical compositions of the present invention

Get the medicinal liquid of embodiment 1 preparation, after concentrating, after adding Natrii Sulfas and appropriate amount of starch, dextrin to mix, granulate.

By test example, illustrate beneficial effect of the present invention below.

Clinical (outpatient service) treatment situation of test example pharmaceutical composition of the present invention

(1) accept patient's situation for medical treatment

Gender and the range of age: contain men and women, old and young, possess following symptom feature, accept altogether 391 examples for medical treatment.

Symptom feature:

Around gradually significantly or the dull pain increasing the weight of, after a few hours, stomachache is transferred to right lower abdomen for epigastrium or umbilicus.Or with inappetence, n or V, or there is low grade fever, weak in their early stage, or without obvious General Symptoms.

Or show as:

(1) abdominal pain: be mainly positioned at right lower abdomen, be characterized in discontinuity dull pain or distending pain, time light when heavy, position is more fixing.Most of patients, after heavy meal, motion or standing for a long time, is brought out stomachache and is occurred.

(2) gastrointestinal reaction: patient or have anorexia, dyspepsia in various degree.The course of disease is compared with elder or occur becoming thin, weight loss.General absence of nausea and vomiting, also without abdominal distention, but small number of patients occasionally can occur; Old age and part middle-young patients or with constipation.

(3) abdominal tenderness: tenderness is vital sign, is mainly positioned at right lower abdomen, and general range is less, and position is constant, could occur during weight.Without muscle tonus and rebound tenderness, generally without abdominal mass, or the caecum of the contacted flatulence having.

Medical diagnosis on disease: patient is carried out after inspect by instrument, determine that above-mentioned 391 routine patients suffer from respectively acute appendicitis or chronic appendicitis (acute attack).

(2) treatment standard

Recovery from illness: above-mentioned symptom feature disappears completely, it is abnormal that check has no index of correlation.

Evident in efficacy: above-mentioned symptom obviously alleviates, test rating has certain degree to improve simultaneously.

Curative effect is obvious: the above-mentioned one (patient's symptom and test rating) of getting.

There is certain effect: patient's symptom alleviates to some extent, or index is slightly improved.

Invalid: symptom still, do not improve by index.

(3) Therapeutic Method

1, the made medicinal liquid of embodiment 1, take advantage of when warm at every turn and take 200 to 400ml, or daily 1 bowl, the rice bowl used of having a meal (child is by the preceding method dosing of cutting down according to the circumstance, but need to drink to add and day take number of times), every 4 hours to 6 hours, take once, take according to quantity, if temporarily withdraw while having compared with heavy cold or other new trouble diseases on time.

2, by following points for attention, noted, and science conditioning daily life:

(1) suffer from abdominal pain and can not at will use analgesic before not clarifying a diagnosis, in order to avoid covered the state of an illness after pain relieving, cause delay diagnosis and cause serious consequence.

(2) taking medicine will be in time, on time, thoroughly.In symptom, sign, after disappearing, must continue to take, to consolidate curative effect, reduce recurrence.

(3) should eat liquid diet, as milk, bean milk, rice water, meat soup etc.Or semi-liquid diet, as medicated porridge, rare soft noodles etc.

(4) do not drink, do not smoke, diet is raw, cold, spicy food.Few fried, greasy or stodgy food of edible oil.For the animal flesh of warm character, should control to some extent as sheep, cattle, Carnis Canitis.

(5) be a vegetarian as far as possible more, have a meat diet less; Eat softly more, eat less hard; Eat freshly more, eat less old food; Polyphagia vegetable and fruit.

(6) drinking-water in right amount, water both can in and gastric acid, alleviate the stimulation of gastric juice to ulcer surface, also can supplement the health mild dehydration causing because of diarrhoea simultaneously.

Extenuate and stage of attack not, should note:

(1) be cautious use of chemicals, particularly some antipyretic analgesic and antibiotic medicine, larger to gastrointestinal irritation, also can cause that digestive tract hemorrhage even bores a hole when serious, preferably uses no or little.

(2) avoid eating and drinking without temperance, eating and drinking too much at one meal is not had more meals a day but less food at each as far as possible, does not carry out after meal strenuous exercise etc. at once.

(3) treat in time constipation and Enterozoa.

(4) regulate cold temperature, do not suffer from cold.Note season, climate change, in time regulate self body and natural relation, day heat subtracts clothing, day trembles with fear to add clothing, especially guarantees that abdominal part avoids cold stimulation, safeguards gastrointestinal normal function state.

(5) prevent overtired because overwork can make human body resistance against diseases decline and cause morbidity or aggravation.

(6) spirit and happy emotion keep pleasant.The bad feelings will such as worried, gloomy, angry, sad stimulates, and emotion changes, easily breaks neural balance, causes nervous disorder, especially autonomic nervous dysfunction.Autonomic nervous dysfunction can have many-sided performance, and gastrointestinal function is not normal is one of its common manifestation.Under direct stimulation effect, gastrointestinal tract generation spasm or relax, causes dyspepsia, constipation, diarrhoea etc., can bring out appendicitis.Therefore, should keep the good mental status, optimism, avoids violent emotion changes.

(7) strengthen mild exercise, health invigorating, attention to hygiene, will cultivate good health habits at ordinary times.

(4) therapeutic outcome

Between many decades, with embodiment 1 medicine composite for curing primary disease men and women, old and young patient 391 examples (in the majority with the young and the middle aged), obtained good curative effect.Treatment time, difference according to the difference of the concrete conditions such as each conditions of patients weight, age size, physical strength and to some extent, the effect generally just having clearly at 1 day to 2 days, can finish to treat for about 1 week～3 weeks, uses above-mentioned conditioning instead and receives merit.By above-mentioned treatment standard, in 391 routine patients, there are 238 example recoveries from illness, cure rate reaches 61%; 76 routine effects are remarkable, reach 19.4%; 43 routine successfuls, account for 11%; 32 examples have certain effect, account for 8.1%; 2 routine DeGrains (invalid), account for 0.5%.Total effective rate reaches 99.5%.

One of model case

Patient, man, 32 years old, body was strong, burst epigastrium pain, after a few hours, pain is transferred to right lower abdomen, decreased food intake, 37 degrees Celsius of body temperature, hospital examines as acute appendicitis.The pharmaceutical composition that gives the embodiment of the present invention 2 preparations gives clothes, owing to being the special and violent Radix Et Rhizoma Rhei of exerting oneself, only takes potion, and defecation is foul, and every day, pain die-offed for several times.Take potion, pain i.e. basic disappearance again, and tripe abdomen is pleasant, and appetite increases.Excessive for anti-drastic purgation, also for consolidating curative effect, then advise it to continue to take four doses, but use the pharmaceutical composition into embodiment 1 instead, no longer with Radix Et Rhizoma Rhei, use Radix et Rhizoma Rhei (processed with wine) instead.Four doses take after, warn patient by " points for attention " science conditioning daily life of above-mentioned " Therapeutic Method " they " 2 ", after January, patient fully recovers.So far more than 10 years, patient had no recurrence.

Two of model case

Patient, female, 24 years old, certain spinner of cotton printing and dyeing mill, conceived nearly July, patient's pain under xiphoid-process that happens suddenly, after a few hours, pain is transferred to right lower abdomen, and loss of appetite is felt sick, 37.5 degrees Celsius of body temperature.With the pharmaceutical composition administration of the embodiment of the present invention 1 preparation, because it has pregancy, each pharmaceutical quantities reduces to 2/3rds, does not cause abnormal fetal movement after taking, and takes medicine continuously 3, and defecation is foul, and every day, pain symptom alleviated gradually for several times, finally disappeared.Due to pregnancy, curative effect is not consolidated in administration again.

Time spend February about, due to its eating and drinking without temperance, cause again Right Lower Abdomen pain, and increase the weight of gradually.Consider its closely Confinement Time (only poor January is remaining), be then hospitalized for treatment, doctor trained in Western medicine is examined as appendicitis acute attack, inform and must immediate surgery excise vermiform appendix, but this operation is larger on fetus impact.Anemia of pregnant woman can not use the antibiotic such as penicillin, gentamycin because of susceptibility, and requires to keep fetus, and through consulting, determining first to adopt erythromycin antiinflammatory is main non-operative treatment, and agrees to pharmaceutical composition interventional therapy of the present invention.In the case, by embodiment 1 pharmaceutical compositions, and full dose gives patient and takes, every 4 hours clothes once.After taking medicine, patient's defecation is foul, and every day for several times, pain relief, takes medicine once so change 6 hours into, and take medicine 3 times (24 hours) after 3 days, to change to one, pain constantly alleviates, fetus there is no unusual fluctuation, adheres to taking according to quantity Chinese medicine every day, until the 9th day on time, pain disappears entirely, mental status recovers as before, leaves hospital latter 10 days, gives birth to healthy girl baby.So far 25 years, this patient had no recurrence.

In sum, various acute appendicitiss and chronic appendicitis acute epilepsy can effectively be eliminated or greatly alleviate to pharmaceutical composition of the present invention, appendicitis is had to certain healing effect, can allow patient exempt appendectomy, and, this pharmaceutical composition is without obvious toxic-side effects, for clinical treatment appendicitis provides a kind of safe and effective novel drugs.

Claims (7)

1. the typhlitic pharmaceutical composition for the treatment of, is characterized in that: it is the preparation that the crude drug by following weight proportion is prepared from:

12 parts of Radix Et Rhizoma Rhei, 8 parts, Natrii Sulfas, 12 parts, Semen Persicae, 12 parts of Cortex Moutans, 15 parts of Cortex Magnoliae Officinalis, 12 parts of Fructus Aurantii Immaturuss, 30 parts of Semen Benincasaes, 10 parts of the Radixs Angelicae Dahuricae, 30 parts of Caulis Sargentodoxaes, 30 parts of Herba Patriniaes, 30 parts of Herba Violaes.

2. the typhlitic pharmaceutical composition for the treatment of according to claim 1, is characterized in that: described Radix Et Rhizoma Rhei is Radix et Rhizoma Rhei (processed with wine).

3. the typhlitic pharmaceutical composition for the treatment of according to claim 1 and 2, is characterized in that: described preparation is oral formulations.

4. the typhlitic pharmaceutical composition for the treatment of of stating according to claim 3, is characterized in that: described oral formulations is oral liquid, granule, pill, capsule, tablet or powder.

5. the typhlitic pharmaceutical composition for the treatment of according to claim 3, is characterized in that: described oral formulations is drop pill or soft capsule.

6. the preparation method of pharmaceutical composition described in claim 1, is characterized in that: it comprises the steps:

(1) by proportioning weighting raw materials;

(2) get other crude drug except Radix Et Rhizoma Rhei, Natrii Sulfas, after decocting with water, rear lower Radix Et Rhizoma Rhei, after having decocted, merges decocting liquid, then adds Natrii Sulfas, by pharmaceutically conventional method, is prepared into common dosage forms.

7. the purposes of the pharmaceutical composition described in claim 1-5 any one in the medicine of preparation treatment acute appendicitis or chronic appendicitis acute epilepsy.