CN101152511A - Medicament for treating hyperthyroidism disease and method of preparing the same - Google Patents
Medicament for treating hyperthyroidism disease and method of preparing the same Download PDFInfo
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- CN101152511A CN101152511A CNA2007101896685A CN200710189668A CN101152511A CN 101152511 A CN101152511 A CN 101152511A CN A2007101896685 A CNA2007101896685 A CN A2007101896685A CN 200710189668 A CN200710189668 A CN 200710189668A CN 101152511 A CN101152511 A CN 101152511A
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Abstract
The invention relates to a medicine for curing hyperthyroidism and a method of preparing the medicine. The medicine is composed of 10 to 40 portion of fresh yam, 10 to 40 portion of raw oyster, 10 to 40 portion of fortune's drynaria rhizome, 10 to 40 portion of milkvetch root, 10 to 40 portion of pumice, 10 to 40 portion of climbing groundsel herb, 10 to 40 portion of spicaprunellae, 10 to 40 portion of sargassum, 10 to 40 portion of thallus eckloniae, 10 to 40 portion of white mustard seed, 5 to 20 portion of thunberg fritillary bulb, 5 to 20 portion of tuber pinelliak, 5 to 20 portion of angelica, 5 to 20 portion of ampelopsis japonica, 5 to 20 portion of pipewort, 5 to 20 portion of tangshen, 5 to 20 portion of trigone, 5 to 20 portion of rhizoma zedoariae, 2 to 8 portion of cyclophosphamide and 0.3 to 1 portion of tapazole by the weight percent, which are processed through a series of procedures, including medicine selection, drying arrow crushing, sifting arrow sterilization arrow preparation and packaging. The invention is characterized by quick effect, short period of treatment, high therapeutic effect, little toxicity and side effect, convenience in being taken and prevention of recurrence, etc.
Description
Technical field
The invention belongs to field of medicine preparing technology, especially a kind of medicine and preparation method that is used for the treatment of hyperthyroidism disease.
Background technology
Hyperthyroidism is hyperthyroidism just, and it is a kind of more common clinically endocrinopathy, surplus in the of nearly 10 year over its sickness rate tangible ascendant trend is arranged.Diffuse toxic goiter claims the Graves disease again, account for whole hyperthyroidism patients' 90%, it is a kind of organ specificity autoimmune disease, owing to due to the immune dysfunction, can cause to produce multiple thyroid autoantibody in the body, as thyroid stimulating antibody (TsAb), it stimulates the thyroid hypertrophy, increased functionality, thyroid hormone secretion is too much, thereby causes body multisystem hypermetabolism syndrome and high excited symptom.Because hyperthyroidism can cause organ injury such as the heart, liver, kidney, eye and bring out multiple complications that very big to patient body harm, hyperthyroidism should adopt reasonable method to treat once making a definite diagnosis immediately.
The medicine for the treatment of hyperthyroidism at present clinically mainly contains internal medicine Western medicine, Chinese medicine, iodine
131, surgical operation therapy.Though surgical operation is cured very fast, expense is higher, excises very few easy recurrence, and excision too much can cause hypothyroidism, and complication such as operation easy damaged recurrent laryngeal nerve.Iodine
131The isotope therapy method is simple, economy, cure rate height, but also easily causes hypothyroidism or recurrence, and it is just right that concrete dosage is difficult to grasp.
Treatment by Chinese herbs hyperthyroidism side effect is little, but effective percentage, cure rate is still unsatisfactory.Therefore, hyperthyroid patient still adopts the internal medicine conservative treatment mostly at present, and medical treatment now is mainly antithyroid drug, its effect is suppress thyroxin synthetic, common drug is thiamazole, carbimazole, propylthiouracil, though effective percentage is higher, onset is slow, the course of treatment is long, be difficult to remove thyroid antibody, drug withdrawal is recurred easily, and takes easy generation toxic and side effects for a long time.
In view of the present situation urgent need is a kind of efficiently, Time of Administration is short, toxic and side effects is little, be difficult for the new medicine and the preparation method of recurrence.
Summary of the invention
For addressing the above problem, the invention provides a kind of medicine and preparation method that is used for the treatment of hyperthyroidism disease, utilize the medicine of the made treatment hyperthyroidism disease of this preparation method, it is little to have an instant effect, short treating period, curative effect height, toxic and side effects, taking convenience, is difficult for characteristics such as recurrence.
In order to realize the foregoing invention purpose, the present invention has adopted following technical scheme:
The described drug component that is used for the treatment of hyperthyroidism disease is constructed as follows by weight:
Rhizoma Dioscoreae: 10-40 part; Concha Ostreae: 10-40 part; Rhizoma Drynariae: 10-40 part; The Radix Astragali: 10-40 part; Pumex: 10-40 part; Herba Senecionis Scandentis: 10-40 part; Spica Prunellae: 10-40 part; Sargassum: 10-40 part; Thallus Laminariae (Thallus Eckloniae): 10-40 part; Semen Sinapis Albae: 10-40 part; Bulbus Fritillariae Thunbergii: 5-20 part; The Rhizoma Pinelliae: 5-20 part; Radix Angelicae Sinensis: 5-20 part; Radix Ampelopsis: 5-20 part; Flos Eriocauli: 5-20 part; Radix Codonopsis: 5-20 part; Rhizoma sparganic: 5-20 part; Rhizoma Curcumae: 5-20 part; Cyclophosphamide: 2-8 part; Thiamazole: 0.3-1 part.
The described process for preparing medicine that is used for the treatment of hyperthyroidism disease is with Rhizoma Dioscoreae 10-40 part, Concha Ostreae 10-40 part, Rhizoma Drynariae 10-40 part, Radix Astragali 10-40 part, Pumex 10-40 part, Herba Senecionis Scandentis 10-40 part, Spica Prunellae 10-40 part, Sargassum 10-40 part, Thallus Laminariae (Thallus Eckloniae) 10-40 part, Semen Sinapis Albae 10-40 part, Bulbus Fritillariae Thunbergii 5-20 part, Rhizoma Pinelliae 5-20 part, Radix Angelicae Sinensis 5-20 part, Radix Ampelopsis 5-20 part, Flos Eriocauli 5-20 part, Radix Codonopsis 5-20 part, rhizoma sparganic 5-20 part, Rhizoma Curcumae 5-20 part, cyclophosphamide 2-8 part, thiamazole 0.3-1 part is carried out component by this weight ratio, and through selecting medicine, drying → pulverizing, sieve → sterilization → the preparation package processing forms, wherein:
One. select medicine, drying:
1. the Semen Sinapis Albae in the such scheme is chosen decontamination sieve dust, gone into the interior moderate heat of iron pan and constantly stir stir-fry to yellow, little have fragrance to get final product, and cools standby;
2. Rhizoma Drynariae: fine sand put in the pot make popular, high-quality Rhizoma Drynariae decoction pieces is gone into to stir in the pot to bubbling, take out sieve and remove fine sand, wipe hair, clean that to go into about 80 ℃ bakings of baking box 4-6 hour after drying standby to water content≤0.5%;
3. the Radix Astragali, Bulbus Fritillariae Thunbergii, Radix Angelicae Sinensis, Radix Ampelopsis, Radix Codonopsis, Rhizoma Pinelliae Preparata, rhizoma sparganic, Rhizoma Curcumae clean twice with clear water respectively, take out that to go into about 80 ℃ bakings of baking box 4-6 hour after drying standby to water content≤0.5%;
4. Concha Ostreae is broken into fritter or coarse powder shape to go into about 80 ℃ bakings of baking box 8-10 hour standby to water content≤0.5%;
5. Spica Prunellae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Herba Senecionis Scandentis, Flos Eriocauli are gone into clear water respectively and are cleaned secondary, take out to dry the same Rhizoma Dioscoreae in back, Pumex and go into about 60 ℃ bakings of baking box 4-6 hour to water content≤0.5% respectively and take out standby;
Two. pulverize, sieve:
The above-mentioned whole raw material of Chinese medicine that made are gone into pulverizer by described weight ratio mix homogeneously pulverize twice, cross 100 mesh sieves and be combined as composition A;
The cyclophosphamide powder of purity 〉=99.8% and purity 〉=99.6% thiamazole powder is crossed 100 mesh sieves, by described weight ratio take by weighing behind the two medicated powder mix homogeneously composition B;
Three. sterilization:
Composition A is carried out ripening, sterilization treatment 10-20 minute at 100-105 ℃; With composition B disinfection by ultraviolet light sterilization 1 hour;
Four. the preparation packing:
Composition A and composition B after the sterilization are carried out mix homogeneously under aseptic condition, encapsulated, bottling sealing at last.
Owing to take technical scheme as mentioned above, the present invention has following superiority:
1. start with from the hyperthyroidism pathogeny, creationary adding, used the immunosuppressant cyclophosphamide, fundamentally corrected hyperthyroidism patient's immunologic function disorder, suppressed the generation of multiple thyroid autoantibody, thereby shortened the course of treatment greatly, taking medicine from the several years in past is reduced to 4-6 month, and curative effect greatly improves, and also can reduce the consumption of antithyroid drug such as thiamazole.
2. keep away the weak point of doctor trained in Western medicine with the length of the traditional Chinese medical science, improve curative effect and reduce the Western medicine toxic and side effects: use hard masses softening and resolving, removing heat-phlegm, the clots absorbing Chinese medicine of regulating the flow of vital energy correction dysthyroid, endocrine regulation is to improve curative effect.Use QI invigorating kidney tonifying, the Chinese medicine of invigorating blood circulation enhancing body immunity, reduce the various toxic and side effects of thiamazole, cyclophosphamide.From practical application, effect is remarkable really, and the serious side effects such as leukopenia, hepatic injury and bone marrow depression of over one hundred routine hyperthyroid patient of controlling are rare.
3. the property of medicine is stable, easily preserves, and is difficult for going mouldy and rotten.
4. curative effect height, be difficult for recurrence: the present invention is because Chinese medicine preparation is reasonable, the grand effect work of Western medicine power, treating both the principal and secondary aspects of a disease, thoroughly removed the paathogenic factor of hyperthyroidism, not only efficient, quick-acting, and seldom recurrence after curing, having solved an in the past thorny recurrence difficult problem, is that the healing of hyperthyroidism becomes simple and light.
5. general hyperthyroid patient gets final product with compound recipe hyperthyroidism capsule, and serious symptom or obstinate patient Ke Jia hormone prednisone can be cured in 4-6 month, cure rate 98%, and relapse rate 10% obviously is better than existing various treatment.
The specific embodiment
Embodiment 1: the drug component that is used for the treatment of hyperthyroidism disease is by weight specifically being constructed as follows:
40 parts of Rhizoma Dioscoreae, 40 parts of Concha Ostreae, 40 parts of Rhizoma Drynariae, 40 parts of the Radixs Astragali, 40 parts of Pumexs, 40 parts of Herba Senecionis Scandentiss, 40 parts of Spica Prunellaes, 40 parts of Sargassums, 40 parts of Thallus Laminariae (Thallus Eckloniae)s, 40 parts of Semen Sinapis Albaes, 20 parts of Radix Angelicae Sinensis, 20 parts of Bulbus Fritillariae Thunbergiis, 20 parts of the Rhizoma Pinelliaes, 20 parts of Radix Ampelopsis, 20 parts of Flos Eriocaulis, 20 parts of Radix Codonopsis, 20 parts of rhizoma sparganic, 20 parts of Rhizoma Curcumae, 8 parts of cyclophosphamide, 1 part of thiamazole.
Embodiment 2: the drug component that is used for the treatment of hyperthyroidism disease is by weight specifically being constructed as follows:
30 parts of Rhizoma Dioscoreae, 30 parts of Concha Ostreae, 40 parts of Rhizoma Drynariae, 40 parts of the Radixs Astragali, 20 parts of Pumexs, 20 parts of Herba Senecionis Scandentiss, 20 parts of Spica Prunellaes, 20 parts of Sargassums, 20 parts of Thallus Laminariae (Thallus Eckloniae)s, 20 parts of Semen Sinapis Albaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Bulbus Fritillariae Thunbergiis, 15 parts of the Rhizoma Pinelliaes, 15 parts of Radix Ampelopsis, 15 parts of Flos Eriocaulis, 15 parts of Radix Codonopsis, 10 parts of rhizoma sparganic, 10 parts of Rhizoma Curcumae, 4 parts of cyclophosphamide, 0.5 part of thiamazole.
Embodiment 3: the drug component that is used for the treatment of hyperthyroidism disease is by weight specifically being constructed as follows:
10 parts of Rhizoma Dioscoreae, 10 parts of Concha Ostreae, 15 parts of Rhizoma Drynariae, 15 parts of the Radixs Astragali, 10 parts of Pumexs, 10 parts of Herba Senecionis Scandentiss, 10 parts of Spica Prunellaes, 10 parts of Sargassums, 10 parts of Thallus Laminariae (Thallus Eckloniae)s, 10 parts of Semen Sinapis Albaes, 10 parts of Radix Angelicae Sinensis, 10 parts of Bulbus Fritillariae Thunbergiis, 10 parts of the Rhizoma Pinelliaes, 10 parts of Radix Ampelopsis, 10 parts of Flos Eriocaulis, 10 parts of Radix Codonopsis, 6 parts of rhizoma sparganic, 6 parts of Rhizoma Curcumae, 2 parts of cyclophosphamide, 0.3 part of thiamazole.
In sum, the Semen Sinapis Albae among above-mentioned 3 kinds of embodiment is chosen decontamination sieve dust, go into the interior moderate heat of iron pan and constantly stir stir-fry to yellow, little have fragrance to get final product, and cools standby.
Rhizoma Drynariae: fine sand put in the pot make popular, the Rhizoma Drynariae decoction pieces is gone into to stir in the pot to bubbling, take out sieve and remove fine sand, the sassafras unhairing cleans that to go into about 80 ℃ bakings of baking box 4-6 hour after drying standby to water content≤0.5%.
The Radix Astragali, Bulbus Fritillariae Thunbergii, Radix Angelicae Sinensis, Radix Ampelopsis, Radix Codonopsis, Rhizoma Pinelliae Preparata, rhizoma sparganic, Rhizoma Curcumae clean twice with clear water respectively, take out that to go into about 80 ℃ bakings of baking box 4-6 hour after drying standby to water content≤0.5%.
Concha Ostreae is broken into fritter or coarse powder shape, and to go into about 80 ℃ bakings of baking box 8-10 hour standby to water content≤0.5%.
Spica Prunellae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Herba Senecionis Scandentis, Flos Eriocauli are gone into clear water respectively and are cleaned secondary, take out to dry the same Rhizoma Dioscoreae in back, Pumex and go into about 60 ℃ bakings of baking box 4-6 hour to water content≤0.5% respectively and take out standby.
Whole raw material of Chinese medicine that above-mentioned 3 kinds of embodiment have made are gone into pulverizer pulverizing twice by described weight ratio mix homogeneously, cross 100 mesh sieves and be combined as composition A.
The cyclophosphamide powder of purity 〉=99.8% and purity 〉=99.6% thiamazole powder is crossed 100 mesh sieves, by described weight ratio take by weighing behind the two medicated powder mix homogeneously composition B.
Composition A is carried out ripening, sterilization treatment 10-20 minute at 100-105 ℃.
With composition B disinfection by ultraviolet light sterilization 1 hour.
Composition A and composition B after the sterilization are carried out mix homogeneously under aseptic condition, encapsulated, bottling sealing at last.
Serious symptom or obstinate patient Ke Jia hormone prednisone.
Claims (2)
1. medicine that is used for the treatment of hyperthyroidism disease, it is characterized in that: this medicine components is constructed as follows by weight:
Rhizoma Dioscoreae: 10-40 part; Concha Ostreae: 10-40 part; Rhizoma Drynariae: 10-40 part; The Radix Astragali: 10-40 part; Pumex: 10-40 part; Herba Senecionis Scandentis: 10-40 part; Spica Prunellae: 10-40 part; Sargassum: 10-40 part; Thallus Laminariae (Thallus Eckloniae): 10-40 part; Semen Sinapis Albae: 10-40 part; Bulbus Fritillariae Thunbergii: 5-20 part; The Rhizoma Pinelliae: 5-20 part; Radix Angelicae Sinensis: 5-20 part; Radix Ampelopsis: 5-20 part; Flos Eriocauli: 5-20 part; Radix Codonopsis: 5-20 part; Rhizoma sparganic: 5-20 part; Rhizoma Curcumae: 5-20 part; Cyclophosphamide: 2-8 part; Thiamazole: 0.3-1 part.
2. process for preparing medicine that is used for the treatment of hyperthyroidism disease, it is characterized in that: this process for preparing medicine is with Rhizoma Dioscoreae 10-40 part, Concha Ostreae 10-40 part, Rhizoma Drynariae 10-40 part, Radix Astragali 10-40 part, Pumex 10-40 part, Herba Senecionis Scandentis 10-40 part, Spica Prunellae 10-40 part, Sargassum 10-40 part, Thallus Laminariae (Thallus Eckloniae) 10-40 part, Semen Sinapis Albae 10-40 part, Bulbus Fritillariae Thunbergii 5-20 part, Rhizoma Pinelliae 5-20 part, Radix Angelicae Sinensis 5-20 part, Radix Ampelopsis 5-20 part, Flos Eriocauli 5-20 part, Radix Codonopsis 5-20 part, rhizoma sparganic 5-20 part, Rhizoma Curcumae 5-20 part, cyclophosphamide 2-8 part, thiamazole 0.3-1 part is carried out component by this weight ratio, and through selecting medicine, drying → pulverizing, sieve → sterilization → the preparation package processing forms, wherein:
One. select medicine, drying:
1. the Semen Sinapis Albae in the such scheme is chosen decontamination sieve dust, gone into the interior moderate heat of iron pan and constantly stir stir-fry to yellow, little have fragrance to get final product, and cools standby;
2. Rhizoma Drynariae: fine sand put in the pot make popular, high-quality Rhizoma Drynariae decoction pieces is gone into to stir in the pot to bubbling, take out sieve and remove fine sand, wipe hair, clean that to go into about 80 ℃ bakings of baking box 4-6 hour after drying standby to water content≤0.5%;
3. the Radix Astragali, Bulbus Fritillariae Thunbergii, Radix Angelicae Sinensis, Radix Ampelopsis, Radix Codonopsis, Rhizoma Pinelliae Preparata, rhizoma sparganic, Rhizoma Curcumae clean twice with clear water respectively, take out that to go into about 80 ℃ bakings of baking box 4-6 hour after drying standby to water content≤0.5%;
4. Concha Ostreae is broken into fritter or coarse powder shape to go into about 80 ℃ bakings of baking box 8-10 hour standby to water content≤0.5%;
5. Spica Prunellae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Herba Senecionis Scandentis, Flos Eriocauli are gone into clear water respectively and are cleaned secondary, take out to dry the same Rhizoma Dioscoreae in back, Pumex and go into about 60 ℃ bakings of baking box 4-6 hour to water content≤0.5% respectively and take out standby;
Two. pulverize, sieve:
The above-mentioned whole raw material of Chinese medicine that made are gone into pulverizer by described weight ratio mix homogeneously pulverize twice, cross 100 mesh sieves and be combined as composition A;
The cyclophosphamide powder of purity 〉=99.8% and purity 〉=99.6% thiamazole powder is crossed 100 mesh sieves, by described weight ratio take by weighing behind the two medicated powder mix homogeneously composition B;
Three. sterilization:
Composition A is carried out ripening, sterilization treatment 10-20 minute at 100-105 ℃; With composition B disinfection by ultraviolet light sterilization 1 hour;
Four. the preparation packing:
Composition A and composition B after the sterilization are carried out mix homogeneously under aseptic condition, encapsulated, bottling sealing at last.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101896685A CN101152511A (en) | 2007-09-17 | 2007-09-17 | Medicament for treating hyperthyroidism disease and method of preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101896685A CN101152511A (en) | 2007-09-17 | 2007-09-17 | Medicament for treating hyperthyroidism disease and method of preparing the same |
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| CN101152511A true CN101152511A (en) | 2008-04-02 |
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| CNA2007101896685A Pending CN101152511A (en) | 2007-09-17 | 2007-09-17 | Medicament for treating hyperthyroidism disease and method of preparing the same |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166325A (en) * | 2010-11-19 | 2011-08-31 | 李德儒 | Preparation method of Chinese medicine for treating hyperthyroidism |
| CN102441110A (en) * | 2011-12-01 | 2012-05-09 | 李金金 | Traditional Chinese medicinal composition for auxiliary treatment of hyperthyroidism |
| CN103405729A (en) * | 2013-09-06 | 2013-11-27 | 河南中医学院 | Traditional Chinese medicine for treating stationary thyroid-associated ophthalmopathy |
| CN103656521A (en) * | 2013-12-17 | 2014-03-26 | 孙斌 | Traditional Chinese medicine for treating phlegm-accumulation and blood-stasis syndrome type hyperthyroidism |
| CN104587135A (en) * | 2014-12-30 | 2015-05-06 | 彭焱 | Traditional Chinese medicine for treating hyperthyroidism and preparation method of traditional Chinese medicine |
| CN104623503A (en) * | 2015-02-09 | 2015-05-20 | 王秋霞 | Traditional Chinese medicine preparation for treating hyperthyreosis and preparation process thereof |
-
2007
- 2007-09-17 CN CNA2007101896685A patent/CN101152511A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102166325A (en) * | 2010-11-19 | 2011-08-31 | 李德儒 | Preparation method of Chinese medicine for treating hyperthyroidism |
| CN102166325B (en) * | 2010-11-19 | 2013-03-20 | 董瑞祥 | Preparation method of Chinese medicine for treating hyperthyroidism |
| CN102441110A (en) * | 2011-12-01 | 2012-05-09 | 李金金 | Traditional Chinese medicinal composition for auxiliary treatment of hyperthyroidism |
| CN102441110B (en) * | 2011-12-01 | 2013-08-21 | 李金金 | Traditional Chinese medicinal composition for auxiliary treatment of hyperthyroidism |
| CN103405729A (en) * | 2013-09-06 | 2013-11-27 | 河南中医学院 | Traditional Chinese medicine for treating stationary thyroid-associated ophthalmopathy |
| CN103405729B (en) * | 2013-09-06 | 2015-01-28 | 河南中医学院 | Traditional Chinese medicine for treating stationary thyroid-associated ophthalmopathy |
| CN103656521A (en) * | 2013-12-17 | 2014-03-26 | 孙斌 | Traditional Chinese medicine for treating phlegm-accumulation and blood-stasis syndrome type hyperthyroidism |
| CN103656521B (en) * | 2013-12-17 | 2015-12-02 | 烟台瑞智生物医药科技有限公司 | A kind of Chinese medicine for the treatment of the hyperthyroidism of expectorant knot blood stasis pattern of syndrome |
| CN104587135A (en) * | 2014-12-30 | 2015-05-06 | 彭焱 | Traditional Chinese medicine for treating hyperthyroidism and preparation method of traditional Chinese medicine |
| CN104623503A (en) * | 2015-02-09 | 2015-05-20 | 王秋霞 | Traditional Chinese medicine preparation for treating hyperthyreosis and preparation process thereof |
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