CN104587135A - Traditional Chinese medicine for treating hyperthyroidism and preparation method of traditional Chinese medicine - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating hyperthyroidism and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following raw herb materials: lizard, pelvetia silquosa, podophyllum, dioscorea nipponica makino, seaweed, gelidium amansii, bryozoatum, dysosma versipellis, ulva, akebiaquinata root, nemacystus, procumbent indian mallow root, radix bupleuri, prunus mume, folium citri reticulatae, perilla stem, tall monkshood root, camphorwood and fortune chloranthus herb. The traditional Chinese medicine provided by the invention has the beneficial effects of adjusting the internal secretion, improving the immunity and restoring normal functions of thyroid by use of the traditional Chinese medicine theory of China, has the advantages of fast acting, accurate curative effect, high safety, and no toxic or side effect on treatment of hyperthyroidism, and is not easy to relapse.

Description

A kind of Chinese medicine and preparation method for the treatment of hyperthyroidism

Technical field

The present invention relates to pharmaceutical technology, particularly relate to a kind of Chinese medicine and preparation method for the treatment of hyperthyroidism.

Background technology

Hyperthyroidism is hyperthyroid abbreviation, be the thyroid hormone secretion that caused by many reasons too much one group of common endocrinopathy extremely.Main clinical manifestation is polyphagia, becomes thin, fears heat, hyperhidrosis, cardiopalmus, exciting contour metabolic syndrome, neural and blood vessel excitement strengthens, and thyromegaly in various degree and eye is prominent, hand tremor, shank vascular murmur etc. be feature, serious occurred hyperthyroidism is endangered phase, even threat to life of going into a coma.

Treatment hyperthyroidism mainly contains operative treatment, radioiodine therapy and Western medicine Drug therapy three kinds of modes.1, operative treatment: by the excision of thyroid major part, radical rate is higher, is also the Therapeutic Method of important hyperthyroidism.But due to thyroid deep, the parathyroid gland containing four very little adjustment Ca,P metabolism, if surgical experience is not enough, has excised parathyroid gland because of carelessness, will cause lifelong tetany because of low calcium, in addition, also may damage vagus nerve and cause celostomia.2, radioiodine therapy: radioiodine is by iodine labeling, make after radioactive substance, be also called 131 iodine, with 131 iodine therapy hyperthyroidisms, the history of existing over half a century, from nineteen forty-two the method, since treatment first case hyperthyroid patient, the whole world accepts the hyperthyroid patient of 131 iodine therapies, reach 2,000,000, so far, also existing more than 20 ten thousand Patients with Hyperthyroidisms, receive 131 iodine therapies in China; But radiation treatment exists certain potential safety hazard, there is the dispute that radioiodine therapy may bring out thyroid nodule, cancer and hereditary complication always, cause psychological burden to a lot of patient.3, Drug therapy: by oral drugs, the state of an illness is controlled, but need Long-term taking medicine, can not drug withdrawal without authorization, and the relapse rate of drug withdrawal is about 30% ~ 50%.And some suffers from the patient of severe liver disease, the treatment of this hyperthyroidism can not be adopted.The patient of oral disposition medicine, one to fortnight, must arrive examination in hospital hemogram, liver function, bother very much.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of Chinese medicine and the preparation method that are used for the treatment of hyperthyroidism, and this Chinese medicine has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of hyperthyroidism, it is characterized in that, comprise following raw medicinal material: Japalurae, Pelvetia siliquosa Tseng et C. F. Chang, Rhizoma Dysosmae Versipellis, Rhizoma Dioscoreae Nipponicae, Sargassum, Eucheuma gelatinosum, Pumex, Radix et Rhizoma Dysosmatis, ulva, Radix Akebiae, Nemacystus decipiens (Sur.) Kuck, Radix urenae procumbentis, Radix Bupleuri, Flos Mume, Folium Citri tangerinae, Caulis Perillae, Radix aconiti sinomontani, Lignum cinnamomi camphorae and Radix Chloranthi Fortunei.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 30 ~ 40 parts, Pelvetia siliquosa Tseng et C. F. Chang 25 ~ 35 parts, Rhizoma Dysosmae Versipellis 20 ~ 30 parts, Rhizoma Dioscoreae Nipponicae 10 ~ 20 parts, Sargassum 20 ~ 30 parts, Eucheuma gelatinosum 10 ~ 20 parts, Pumex 5 ~ 15 parts, Radix et Rhizoma Dysosmatis 5 ~ 15 parts, ulva 15 ~ 25 parts, Radix Akebiae 10 ~ 20 parts, Nemacystus decipiens (Sur.) Kuck 20 ~ 30 parts, Radix urenae procumbentis 5 ~ 15 parts, Radix Bupleuri 30 ~ 40 parts, 20 ~ 30 parts, Flos Mume, Folium Citri tangerinae 10 ~ 20 parts, Caulis Perillae 20 ~ 30 parts, Radix aconiti sinomontani 5 ~ 15 parts, Lignum cinnamomi camphorae 10 ~ 20 parts and Radix Chloranthi Fortunei 5 ~ 15 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 35 ~ 40 parts, Pelvetia siliquosa Tseng et C. F. Chang 30 ~ 35 parts, Rhizoma Dysosmae Versipellis 20 ~ 25 parts, Rhizoma Dioscoreae Nipponicae 10 ~ 15 parts, Sargassum 25 ~ 30 parts, Eucheuma gelatinosum 15 ~ 20 parts, Pumex 5 ~ 10 parts, Radix et Rhizoma Dysosmatis 5 ~ 10 parts, ulva 20 ~ 25 parts, Radix Akebiae 10 ~ 15 parts, Nemacystus decipiens (Sur.) Kuck 20 ~ 25 parts, Radix urenae procumbentis 10 ~ 15 parts, Radix Bupleuri 30 ~ 35 parts, 25 ~ 30 parts, Flos Mume, Folium Citri tangerinae 10 ~ 15 parts, Caulis Perillae 20 ~ 25 parts, Radix aconiti sinomontani 5 ~ 10 parts, Lignum cinnamomi camphorae 15 ~ 20 parts and Radix Chloranthi Fortunei 10 ~ 15 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 36 parts, Pelvetia siliquosa Tseng et C. F. Chang 31 parts, Rhizoma Dysosmae Versipellis 24 parts, Rhizoma Dioscoreae Nipponicae 11 parts, Sargassum 27 parts, Eucheuma gelatinosum 16 parts, Pumex 9 parts, Radix et Rhizoma Dysosmatis 5 parts, ulva 22 parts, Radix Akebiae 13 parts, Nemacystus decipiens (Sur.) Kuck 24 parts, Radix urenae procumbentis 12 parts, Radix Bupleuri 31 parts, 28 parts, Flos Mume, Folium Citri tangerinae 14 parts, Caulis Perillae 23 parts, Radix aconiti sinomontani 6 parts, Lignum cinnamomi camphorae 18 parts and Radix Chloranthi Fortunei 12 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 38 parts, Pelvetia siliquosa Tseng et C. F. Chang 34 parts, Rhizoma Dysosmae Versipellis 22 parts, Rhizoma Dioscoreae Nipponicae 13 parts, Sargassum 30 parts, Eucheuma gelatinosum 17 parts, Pumex 6 parts, Radix et Rhizoma Dysosmatis 8 parts, ulva 20 parts, Radix Akebiae 11 parts, Nemacystus decipiens (Sur.) Kuck 21 parts, Radix urenae procumbentis 14 parts, Radix Bupleuri 33 parts, 26 parts, Flos Mume, Folium Citri tangerinae 12 parts, Caulis Perillae 22 parts, Radix aconiti sinomontani 8 parts, Lignum cinnamomi camphorae 16 parts and Radix Chloranthi Fortunei 15 parts.

Wherein, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps,

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 30 ~ 60 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 3 ~ 6 times obtained relative to the first step is the ethanol of 70 ~ 80%, and reflux 2 ~ 4 hours, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times again, each decoction 2 ~ 5 hours, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

Wherein, when the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:

The first step, Japalurae, Pelvetia siliquosa Tseng et C. F. Chang, Rhizoma Dysosmae Versipellis, Rhizoma Dioscoreae Nipponicae, Sargassum, Eucheuma gelatinosum, Pumex, Lignum cinnamomi camphorae and Radix Chloranthi Fortunei are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 3 ~ 5 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into powder; Then add the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decoct 2 ~ 4 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to filtering residue quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;

3rd step, the powder mixing first step and second step obtained, add the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Beneficial effect of the present invention: Chinese medicine of the present invention, utilize the theory of Chinese medical science that China is traditional, can improve immunity by endocrine regulation, recover thyroid normal function, treatment hyperthyroidism has the advantage that rapid-action, determined curative effect, safety are high, have no side effect and not easily recur.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of hyperthyroidism, wherein, following raw medicinal material is comprised: Japalurae, Pelvetia siliquosa Tseng et C. F. Chang, Rhizoma Dysosmae Versipellis, Rhizoma Dioscoreae Nipponicae, Sargassum, Eucheuma gelatinosum, Pumex, Radix et Rhizoma Dysosmatis, ulva, Radix Akebiae, Nemacystus decipiens (Sur.) Kuck, Radix urenae procumbentis, Radix Bupleuri, Flos Mume, Folium Citri tangerinae, Caulis Perillae, Radix aconiti sinomontani, Lignum cinnamomi camphorae and Radix Chloranthi Fortunei.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Japalurae: be the entirety of the grass green imperial lizard of Iguanidae animal.Latin plant animal mineral name: Japaluraflaviceps Barbouret Dunn.Salty in the mouth; Cold in nature; Poisonous.Return liver; Kidney channel.Removing toxic substances disappears wart; Hard masses softening and resolving.Main goiter; Tuberculosis; Scrofula is not burst; Carbuncle sore tumefacting virus." China's book on Chinese herbal medicine "

Pelvetia siliquosa Tseng et C. F. Chang: be the frond of Fucus Vesiculosus section plant Pelvetia siliquosa Tseng et C. F. Chang.Latin plant animal mineral name: Pelvetiasiliquosa Tseng et C.F.Chang [Pelvetia minorNoda].Salty; Great Cold.Removing heat-phlegm; Hard masses softening and resolving.Main consumptive fever hectic fever due to YIN-deficiency; Phlegm-heat cough; Pulmonary tuberculosis; Goiter; Scrofula." China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Rhizoma Dysosmae Versipellis: be the rhizome of Berberidaceae plant Radix et Rhizoma Dysosmatis.Toil, flat.1. " herbal classic ": " acrid in the mouth, temperature." 2. " not Lu ": " tepor, poisonous." 3. TAO Hong-Jing: " sweet in the mouth, temperature, poisonous." 4. " property of medicine opinion ": " bitter in the mouth." expectorant powder junction, detoxification and removing stasis.Control consumptive disease wound, cough, spit blood, stomachache, goiter, scrofula, carbuncle, furuncle, traumatic injury, snakebite.1. " herbal classic ": " master kills diseases due to noxious agents produced by various parasites, wards off bad odor, by heresy solution hundred poison." 2. " not Lu ": " treats cough Adam's apple, and ailment said due to cold or exposure is tired of puzzled, loses soul visual hallucination, goes skin nebula in order, kill large poison.Do not enter soup." 3. " property of medicine opinion ": " main labor disease." 4. " detailed outline ": " lower stillborn fetus, treating malaria is evil, and carbuncle, snake venom, penetrates work poison." 5. Wang Lian bodyguard " book of gathering medicinal herbs ": " disappears, and all are malicious, the saturating pus of power energy softening the hard mass." 6. " Fujian Chinese herbal medicine ": " lowering the adverse-rising QI and dispelling phlegm, mass dissipating and swelling eliminating." 7. " Chinese herbal medicine folk recipe and treatment war preparedness special edition ": " blood stasis dispelling, eliminating stagnation, removing toxic substances." " Chinese medicine voluminous dictionary "

Rhizoma Dioscoreae Nipponicae: be the rhizome of Dioscoreaceae plant Dioscorea nipponica Mak. Ningpo Yam Rhizome and bavin Dioscorea zingiberensis.Flat; Bitter.Return liver; Lung meridian.Expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Cough-relieving.Before main air arthralgia chiefly caused by damp pathogen; Numb limbs and tense tendons; Obstruction of qi in the chest and cardialgia; Chronic tracheitis; Traumatic injury; Malaria; Carbuncle." China's book on Chinese herbal medicine "

Sargassum: be the dry frond of Sargassaceae plant Sargassum Sargassum pallidum (Turn.) C.Ag. or Sargassum fusiforme (Harv.) Setch Sargassum fusiforme (Harv.) Setch..Bitter, salty, cold.Return liver, stomach, kidney channel.Hard masses softening and resolving, expectorant, diuretic.For goiter, scrofula, painful and swollen testis, phlegm retention edema." Chinese Pharmacopoeia "

Eucheuma gelatinosum: be the frond of Gelidiaceae phytobezoar Herba Astragali Sinici, fine, soft fur Eucheuma gelatinosum, pacific gelidium etc.Sweet; Salty; Cold; Sliding; Nontoxic.Return liver; Lung meridian.Heat-clearing and toxic substances removing; Blood stasis-eliminating and stagnation-dissipating; Laxation; Drive ascarid.Main enteritis, diarrhea; Pyelonephritis; Goiter; Tumor; Bleeding hemorrhoids; Chronic constipation; Ascarid is disease early." China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Pumex: be the block of igneous rock rock Pumex or the skeleton of hilum section animal costazia aculeata Canu et Bassler, costazia costazii Audouin etc.Salty, cold.1. supplement to the Herbal: " flat, nontoxic." 2. Zhu Zhenheng: " is salty." 3. " detailed outline ": " Great Cold." enter lung, kidney channel.1. " beautiful Chinese catalpa medicine solution ": " start with lunar lung, liver channel of foot-Jueyin." 2. " book on Chinese herbal medicine is looked for the truth ": " enters lung, kidney." [function cures mainly] lung heat clearing fire, changes old expectorant, softening the hard mass, treating stranguria.Control expectorant dyspnea of heat type to cough, old accumulation of phlegm block, goiter, scrofula, gonorrhea, hernia, skin ulcer swells, corneal nebula.1. TAO Hong-Jing: " cough-relieving." 2. supplement to the Herbal: " is main thirsty." 3. " Japan hanako materia medica ": " quenches the thirst, and controls pouring, kills wild beast poison." 4. amplification on Canon of Materia Medica: " water flies, and controls nebula in order." 5. Zhu Zhenheng: " clearing and descending lung-fire, removing food stagnancy block, changes old expectorant." 6. " detailed outline ": " goiter that disappears tuberculosis hernia, the therapeutic method to keep the adverse QI flowing downwards, the skin ulcer that disappears swells." 7. " book on Chinese herbal medicine just ": " helps digestion, and disappear heat-phlegm, antipyretic thirsty pyretic stranguria, only phlegmatic cough dyspnea with rapid respiration, Ruan Jian Disorder, and diuretic wets." " Chinese medicine voluminous dictionary "

Radix et Rhizoma Dysosmatis: be the root and rhizome of Berberidaceae plant Radix et Rhizoma Dysosmatis, Dysosma Pleiantha and dysosma veitchii Fu.Bitter in the mouth; Pungent; Cool in nature; Poisonous.[return through] lung; Liver Channel.[function cures mainly] changes what is said or talked about eliminating stagnation; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing.Main cough; Laryngopharynx swelling and pain; Scrofula; Goiter; Carbuncle; Furuncle; Venom; Traumatic injury harm; Arthromyodynia." China's book on Chinese herbal medicine "

Ulva: be the frond of Ulvaceae plant ulva, U. pertusa, sliver ulva.Latin plant animal mineral name: Ulva lactucaL.; Ulva pertusa Kjellm.; Ulva fasciataDelile.Sweet; Salty; Cold; Flat; Nontoxic.[return through] enters kidney channel.[function cures mainly] inducing diuresis to remove edema; Softening and eliminating sputum; Heat-clearing and toxic substances removing.Main edema; Deradenoncus; Goiter; Hypertension; Laryngitis; Furuncle; Acute and chronic gastroenteritis; Infantile malnutrition." China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Radix Akebiae: be plants of Lardizabalaceae Caulis Akebiae Akebia quinata (Thunb.) De-cne. threeleaf akebia A.trifoliata (Thunb.) Koidz. and Caulis Akebiae A.trifoliata (Thunb.Koidz.Var.australis

(Diels) root of Rehd..[nature and flavor] are bitter; Property is put down; Return wing light; Liver Channel; [return through] liver; Kidney channel; [function cures mainly] dispelling wind and removing obstruction in the collateral; Inducing diuresis to remove edema; Circulation of qi promoting; Invigorate blood circulation; Invigorating the liver and kidney; Bone and muscle strengthening.Main air pain of dampness syndrome; Traumatic injury; Amenorrhea; Hernia; Painful and swollen testis; Gastral cavity abdominal distention is vexed; Dysuria; Leukorrhagia; Worm venom; " property of medicine opinion ": control goiter under item." Zhejiang conventional medical herbs among the people ": wind-expelling pain-stopping, promoting flow of QI and blood, diuresis is detoxified." Chinese herbal medicine is commonly used in Sichuan ": control cough with copious phlegm.[extracts] " China's book on Chinese herbal medicine "

Nemacystus decipiens (Sur.) Kuck: be the frond of Nemacystus decipiens (Sur.) Kuck section plant Nemacystus decipiens (Sur.) Kuck.[nature and flavor] are salty; Cold; Nontoxic.[return through] liver; Lung meridian.[function cures mainly] eliminating phlegm and softening indurated mass; Inducing diuresis to remove edema.Main goiter; Goiter; Laryngitis; Bronchitis.Supplement to the Herbal: main goiter stagnation of QI between larynx, lower water.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Radix urenae procumbentis: be the root of Malvaceae plant Herba urenae procumbentis Urena procumbens L..Latin plant animal mineral name: Urena procumbens L. [U.sinuataL.] [nature and flavor] are sweet; Sweet; Flat.[return through] heart; Liver; Lung; Stomach; Spleen; Kidney channel.[function cures mainly] invigorating the spleen for eliminating dampness; Promoting blood circulation and detoxication.Main air pain of dampness syndrome; Overstrain is weak; Hepatitis; Malaria; Edema; Leucorrhea; Traumatic injury; Swollen ulcer drug.[extracts] " China's book on Chinese herbal medicine "

Radix Bupleuri: be the root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Latin plant animal mineral name: 1.Bupleurum chinense DC.2.Bupeurum scorzonerifolium Willd.[nature and flavor] bitter in the mouth; Pungent; Cold nature.[return through] returns liver; Gallbladder meridian.[function cures mainly] is induced sweat and is brought down a fever; Dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Main fever caused by exogenous pathogens; Alternate attack of chill and fever; Malaria; Hypochondriac pain due to stagnation of liverQI mammary swelling; Headache dizziness; Menoxenia; The proctoptosis of collapse of QI; Uterine prolapse; Gastroptosis.[extracts] " China's book on Chinese herbal medicine "

Flos Mume: be the alabastrum of rosaceous plant FLOS MUME.Latin plant animal mineral name: Armeniacamume Sieb. [Prunus mume Sieb.et Zucc.] [nature and flavor] bitter in the mouth, micro-sweet, micro-acid, cool in nature.[return through] returns liver, stomach, lung meridian.[function cures mainly] dispersing the stagnated live-QI to relieve the stagnation of QI, appetizing is promoted the production of body fluid, and reduces phlegm.Be mainly used to gloomy vexed; Stomachache due to hyperactive liver-QI attacking the stomach; Globus hystericus; Scrofula sore.[extracts] " China's book on Chinese herbal medicine "

Folium Citri tangerinae: be the leaf of rutaceae orange Citrus reticulataBlanco and variety thereof.Latin plant animal mineral name: Citrus reticulataBlanco.[nature and flavor] toil; Flat.[return through] Liver Channel.[function cures mainly] is soothing the liver circulation of qi promoting, dissipating phlegm and resolving masses.Main acute mastitis; Breast lumps; Distending pain in the chest and hypochondrium; Hernia.[extracts] " China's book on Chinese herbal medicine "

Caulis Perillae: be the dry stem of labiate Folium Perillae Perilla frutescens (L.) Britt..[nature and flavor] are pungent, temperature.[return through] returns lung, spleen channel.[function cures mainly] regulating the flow of QI to ease the stomach, pain relieving, antiabortive.Vexed for chest and diaphragm painful abdominal mass, gastralgia, belch is vomitted, frequent fetal movement." Chinese Pharmacopoeia "

Radix aconiti sinomontani: be the root of ranunculaceae plant Aconitum sinomontanum Nakai.Latin plant animal mineral name: AconitumsinomontanumNakai.Bitter; Pungent; Temperature; Poisonous.[return through] heart; Liver; Lung; Spleen channel.[function cures mainly] expelling wind and removing dampness; Regulating QI to relieve pain; Promoting blood circulation to remove blood stasis.Main lumbago, skelalgia of rheumatism; Arthralgia; Traumatic injury; Stomachache; Distension and fullness of the chest and abdomen; Acute and chronic bacillary dysentery; Acute chronic enteritis; Scrofula; Furuncle.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Lignum cinnamomi camphorae: be the timber of canella Camphor tree.Latin plant animal mineral name: Cinnamomumcamphora (L.) Presl [Laurus camphoraL.] [nature and flavor] is pungent; Temperature.[return through] liver; Spleen channel.[function cures mainly] expelling wind and cold; Warming middle-JIAO is regulated the flow of vital energy; Promoting blood circulation to remove obstruction in the collateral.Main anemofrigid cold; Cold syndrome of the stomach distending pain; Cold-damp is vomited and diarrhoea; Rheumatic arthralgia; Foot gas; Traumatic pain; Scabies pruritus due to wind pathogen.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "

Radix Chloranthi Fortunei: be root or the herb of the full edge chu lan tree of Chloranthaceae plant.Latin plant animal mineral name: Chloranthus holostegius (Hand.Mazz.) Pei et Shan.[nature and flavor] micro-hardship; Puckery; Warm in nature.[return through] liver; Lung meridian.[function cures mainly] expelling wind and removing dampness; Dissipating blood stasis for subsidence of swelling; Pain relieving.Main air pain of dampness syndrome; Anemofrigid cold; Traumatic injury; Scrofula; Furuncle swells and ache.[extracts] " China's book on Chinese herbal medicine "

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 30 ~ 40 parts, Pelvetia siliquosa Tseng et C. F. Chang 25 ~ 35 parts, Rhizoma Dysosmae Versipellis 20 ~ 30 parts, Rhizoma Dioscoreae Nipponicae 10 ~ 20 parts, Sargassum 20 ~ 30 parts, Eucheuma gelatinosum 10 ~ 20 parts, Pumex 5 ~ 15 parts, Radix et Rhizoma Dysosmatis 5 ~ 15 parts, ulva 15 ~ 25 parts, Radix Akebiae 10 ~ 20 parts, Nemacystus decipiens (Sur.) Kuck 20 ~ 30 parts, Radix urenae procumbentis 5 ~ 15 parts, Radix Bupleuri 30 ~ 40 parts, 20 ~ 30 parts, Flos Mume, Folium Citri tangerinae 10 ~ 20 parts, Caulis Perillae 20 ~ 30 parts, Radix aconiti sinomontani 5 ~ 15 parts, Lignum cinnamomi camphorae 10 ~ 20 parts and Radix Chloranthi Fortunei 5 ~ 15 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 35 ~ 40 parts, Pelvetia siliquosa Tseng et C. F. Chang 30 ~ 35 parts, Rhizoma Dysosmae Versipellis 20 ~ 25 parts, Rhizoma Dioscoreae Nipponicae 10 ~ 15 parts, Sargassum 25 ~ 30 parts, Eucheuma gelatinosum 15 ~ 20 parts, Pumex 5 ~ 10 parts, Radix et Rhizoma Dysosmatis 5 ~ 10 parts, ulva 20 ~ 25 parts, Radix Akebiae 10 ~ 15 parts, Nemacystus decipiens (Sur.) Kuck 20 ~ 25 parts, Radix urenae procumbentis 10 ~ 15 parts, Radix Bupleuri 30 ~ 35 parts, 25 ~ 30 parts, Flos Mume, Folium Citri tangerinae 10 ~ 15 parts, Caulis Perillae 20 ~ 25 parts, Radix aconiti sinomontani 5 ~ 10 parts, Lignum cinnamomi camphorae 15 ~ 20 parts and Radix Chloranthi Fortunei 10 ~ 15 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 36 parts, Pelvetia siliquosa Tseng et C. F. Chang 31 parts, Rhizoma Dysosmae Versipellis 24 parts, Rhizoma Dioscoreae Nipponicae 11 parts, Sargassum 27 parts, Eucheuma gelatinosum 16 parts, Pumex 9 parts, Radix et Rhizoma Dysosmatis 5 parts, ulva 22 parts, Radix Akebiae 13 parts, Nemacystus decipiens (Sur.) Kuck 24 parts, Radix urenae procumbentis 12 parts, Radix Bupleuri 31 parts, 28 parts, Flos Mume, Folium Citri tangerinae 14 parts, Caulis Perillae 23 parts, Radix aconiti sinomontani 6 parts, Lignum cinnamomi camphorae 18 parts and Radix Chloranthi Fortunei 12 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 38 parts, Pelvetia siliquosa Tseng et C. F. Chang 34 parts, Rhizoma Dysosmae Versipellis 22 parts, Rhizoma Dioscoreae Nipponicae 13 parts, Sargassum 30 parts, Eucheuma gelatinosum 17 parts, Pumex 6 parts, Radix et Rhizoma Dysosmatis 8 parts, ulva 20 parts, Radix Akebiae 11 parts, Nemacystus decipiens (Sur.) Kuck 21 parts, Radix urenae procumbentis 14 parts, Radix Bupleuri 33 parts, 26 parts, Flos Mume, Folium Citri tangerinae 12 parts, Caulis Perillae 22 parts, Radix aconiti sinomontani 8 parts, Lignum cinnamomi camphorae 16 parts and Radix Chloranthi Fortunei 15 parts.

Wherein, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps,

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 30 ~ 60 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 3 ~ 6 times obtained relative to the first step is the ethanol of 70 ~ 80%, and reflux 2 ~ 4 hours, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times again, each decoction 2 ~ 5 hours, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

Wherein, when the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:

The first step, Japalurae, Pelvetia siliquosa Tseng et C. F. Chang, Rhizoma Dysosmae Versipellis, Rhizoma Dioscoreae Nipponicae, Sargassum, Eucheuma gelatinosum, Pumex, Lignum cinnamomi camphorae and Radix Chloranthi Fortunei are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 3 ~ 5 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into powder; Then add the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decoct 2 ~ 4 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to filtering residue quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;

3rd step, the powder mixing first step and second step obtained, add the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 capsule of the present invention

Get Japalurae 380g, Pelvetia siliquosa Tseng et C. F. Chang 340g, Rhizoma Dysosmae Versipellis 220g, Rhizoma Dioscoreae Nipponicae 130g, Sargassum 300g, Eucheuma gelatinosum 170g, Pumex 60g, Radix et Rhizoma Dysosmatis 80g, ulva 200g, Radix Akebiae 110g, Nemacystus decipiens (Sur.) Kuck 210g, Radix urenae procumbentis 140g, Radix Bupleuri 330g, Flos Mume 260g, Folium Citri tangerinae 120g, Caulis Perillae 220g, Radix aconiti sinomontani 80g, Lignum cinnamomi camphorae 160g and Radix Chloranthi Fortunei 150g.

Its preparation method comprises the following steps,

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 45 minutes, be ground into smalls, be screened into 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 5 times obtained relative to the first step is the ethanol of 75%, and reflux 3 hours, extracts 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 6 times again, and each decoction 3 hours, decocts 2 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mixes with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract;

3rd step, is broken into 300 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is carboxymethyl starch, and its weight content in described capsule is 25%;

Described disintegrating agent is hydroxypropyl cellulose, and its weight content in described capsule is 10%;

Described fluidizer is magnesium stearate, and its weight content in described capsule is 3.5%.

Embodiment 2 oral solutions of the present invention

Get Japalurae 360g, Pelvetia siliquosa Tseng et C. F. Chang 310g, Rhizoma Dysosmae Versipellis 240g, Rhizoma Dioscoreae Nipponicae 110g, Sargassum 270g, Eucheuma gelatinosum 160g, Pumex 90g, Radix et Rhizoma Dysosmatis 50g, ulva 220g, Radix Akebiae 130g, Nemacystus decipiens (Sur.) Kuck 240g, Radix urenae procumbentis 120g, Radix Bupleuri 310g, Flos Mume 280g, Folium Citri tangerinae 140g, Caulis Perillae 230g, Radix aconiti sinomontani 60g, Lignum cinnamomi camphorae 180g and Radix Chloranthi Fortunei 120g.

Its preparation method comprises the following steps:

The first step, Japalurae, Pelvetia siliquosa Tseng et C. F. Chang, Rhizoma Dysosmae Versipellis, Rhizoma Dioscoreae Nipponicae, Sargassum, Eucheuma gelatinosum, Pumex, Lignum cinnamomi camphorae and Radix Chloranthi Fortunei are mixed in proportion, be that the methanol of 80% is as solvent with determining alcohol, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 5 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into powder; Then add the distilled water of the powder quality 5 times obtained relative to second step, decoct 3 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to filtering residue quality 3 times, decoct 2 hours, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 volume, add the ethanol that determining alcohol is 90%, make determining alcohol reach 75%, leave standstill 20 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;

3rd step, the powder mixing first step and second step obtained, add the distilled water relative to powder quality 4.5 times amount, the sucrose of 0.25 times, the sodium benzoate of 0.015 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

Toxicity test:

Acute toxicity test: the capsule prepared with the embodiment of the present invention 1 and the oral solutions of the embodiment of the present invention 2 are dissolved in distilled water respectively, gives 2 groups of white mice feeding dispensings respectively with 240 of clinical consumption per day times and 350 times respectively, observes 14; The all white mice of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.Irritation test is carried out to white mouse oral cavity and damaged skin, there are no irritative response and other untoward reaction.Illustrate that Chinese medicine of the present invention is little to white mice acute use toxicity, application safety.

Long term toxicity test: the capsule embodiment of the present invention 1 prepared is dissolved in water to mice by 15.48g crude drug/kg, the oral solutions of the embodiment of the present invention 2 is dissolved in water to mice by 32.64g crude drug/kg, continuous uses 16 weeks are distinguished to 2 groups of mices, every day 2 times, and drug withdrawal is after 4 weeks, result shows: Chinese medicine of the present invention is to the hair of 2 groups of test mices, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: fetch the 84 routine hyperthyroid patients coming from the court outpatient, male 32 people, female 52 people; 23 ~ 45 years old age.84 routine patients are divided into treatment by Chinese herbs group and western medicine group at random, treatment by Chinese herbs group 42 people, male 16 people, female 26 people; Western medicine group 42 people, male 16 people, female 26 people.

Diagnostic criteria: according to " internal medicine " the 7th edition teaching material.Have hypermetabolism sings and symptoms, thyromegaly, thyroid function checks serum T T4, FT4, TT3, FT3 increase and TSH lowers.Or have stickiness edema before exophthalmos, shin.

Therapeutic Method:

Treatment by Chinese herbs group: take capsule prepared by the embodiment of the present invention 1, every day 3 times, each 4 30 days is 1 course for the treatment of.

Western medicine group: oral thiamazole sheet, every day 3 times, each 2 30 days is 1 course for the treatment of.

The standard of curative effect evaluation: clinical cure: a. transference cure, body weight increases, and pulse frequency is normal, and region thyreoidea trembles and vascular murmur disappears, and goiter and exophthalmos alleviate; B. serum T 3, T4, FT4 level are normally, thyroid tablet or the T3 inhibition test positive (can suppress), and thyroid immunologic test is normal; Effective: a. symptom takes a turn for the better, and pulse frequency slows down, and goiter is reduced, and vascular murmur alleviates; B. serum T 4, T3, FT4 level are normal, and thyroid tablet or T3 inhibition test feminine gender (can not suppress), still need continual cure.Invalid: a. symptom is without improvement, and pulse frequency change is little, goiter is almost without reducing or becoming large, and vascular murmur is without alleviating; B. serum T 4, T3, FT4 level are still abnormal, thyroid tablet or T3 inhibition test feminine gender (can not suppress).

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs hyperthyroidism of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs hyperthyroidism of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

Table 1 liang group treats Clinical efficacy comparison example (%) after 3 courses for the treatment of respectively

Group	Number of cases	Clinical cure (%)	Effective (%)	Invalid (%)	Total effective rate
						Treatment group	42	27(64.3％)	15(35.7％)	0(0％)	100％
Matched group	42	7(16.7％)	24(57.1％)	11(26.2％)	73.8％

To fully recover after table 2 liang group treats 3 courses for the treatment of respectively number and time comparative example (%)

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of
					Treatment group	27	5(18.5％)	13(48.1％)	9(33.3％)
Matched group	7	0(0％)	2(28.6％)	5(71.4％)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Simultaneously to the 7 routine follow-up of patients 2 years of 27 for the treatment of group clinical cure examples and matched group clinical cure, result is added up, and treatment group 27 example is without recurrence, and the routine patient of matched group 7, recurs 4 people, relapse rate 57.1%.

Model case:

Zhao, man, 39 years old, because " previously suffer from hyperthyroidism 3 years, now the nervous cardiopalmus moon is remaining " is medical.After nervously becoming thin, checking T3T4, be diagnosed as hyperthyroidism during patient 36 years old, and oral with thiamazole, after about one year, symptom obviously improves that to change thiamazole into half qd oral, then drug withdrawal in 1 year.Time have check T3T4, Non Apparent Abnormality.Recently occur because the moon after donating blood is remaining that nervous, times of defecation increases, check T3T4, FT3:6.83pmol/L; FT4:19.72pmol/L, prompting hyperthyroidism recurrence, thyroid B ultrasonic, prompting: thyroid two leaf increases, the thick 22mm of lobus sinister, the thick 24mm of lobus dexter, the thick 4mm of isthmus, and peplos is smooth, inner in middle high echo, uneven, no abnormality seen echo group.EKG, hepatic and renal function, rabat, α-FP, CEA etc. check all negative; Be diagnosed as hyperthyroidism recurrence.Take Chinese medicine preparation embodiment 1 capsule of the present invention, every day 3 times, each 4, treat and be almost recovered for 2 months, fully recover after continuing to take 15 days, follow up a case by regular visits to and do not recur for 2 years.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the Chinese medicine of hyperthyroidism for one kind, it is characterized in that, comprise following raw medicinal material: Japalurae, Pelvetia siliquosa Tseng et C. F. Chang, Rhizoma Dysosmae Versipellis, Rhizoma Dioscoreae Nipponicae, Sargassum, Eucheuma gelatinosum, Pumex, Radix et Rhizoma Dysosmatis, ulva, Radix Akebiae, Nemacystus decipiens (Sur.) Kuck, Radix urenae procumbentis, Radix Bupleuri, Flos Mume, Folium Citri tangerinae, Caulis Perillae, Radix aconiti sinomontani, Lignum cinnamomi camphorae and Radix Chloranthi Fortunei.

2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 30 ~ 40 parts, Pelvetia siliquosa Tseng et C. F. Chang 25 ~ 35 parts, Rhizoma Dysosmae Versipellis 20 ~ 30 parts, Rhizoma Dioscoreae Nipponicae 10 ~ 20 parts, Sargassum 20 ~ 30 parts, Eucheuma gelatinosum 10 ~ 20 parts, Pumex 5 ~ 15 parts, Radix et Rhizoma Dysosmatis 5 ~ 15 parts, ulva 15 ~ 25 parts, Radix Akebiae 10 ~ 20 parts, Nemacystus decipiens (Sur.) Kuck 20 ~ 30 parts, Radix urenae procumbentis 5 ~ 15 parts, Radix Bupleuri 30 ~ 40 parts, 20 ~ 30 parts, Flos Mume, Folium Citri tangerinae 10 ~ 20 parts, Caulis Perillae 20 ~ 30 parts, Radix aconiti sinomontani 5 ~ 15 parts, Lignum cinnamomi camphorae 10 ~ 20 parts and Radix Chloranthi Fortunei 5 ~ 15 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 35 ~ 40 parts, Pelvetia siliquosa Tseng et C. F. Chang 30 ~ 35 parts, Rhizoma Dysosmae Versipellis 20 ~ 25 parts, Rhizoma Dioscoreae Nipponicae 10 ~ 15 parts, Sargassum 25 ~ 30 parts, Eucheuma gelatinosum 15 ~ 20 parts, Pumex 5 ~ 10 parts, Radix et Rhizoma Dysosmatis 5 ~ 10 parts, ulva 20 ~ 25 parts, Radix Akebiae 10 ~ 15 parts, Nemacystus decipiens (Sur.) Kuck 20 ~ 25 parts, Radix urenae procumbentis 10 ~ 15 parts, Radix Bupleuri 30 ~ 35 parts, 25 ~ 30 parts, Flos Mume, Folium Citri tangerinae 10 ~ 15 parts, Caulis Perillae 20 ~ 25 parts, Radix aconiti sinomontani 5 ~ 10 parts, Lignum cinnamomi camphorae 15 ~ 20 parts and Radix Chloranthi Fortunei 10 ~ 15 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 36 parts, Pelvetia siliquosa Tseng et C. F. Chang 31 parts, Rhizoma Dysosmae Versipellis 24 parts, Rhizoma Dioscoreae Nipponicae 11 parts, Sargassum 27 parts, Eucheuma gelatinosum 16 parts, Pumex 9 parts, Radix et Rhizoma Dysosmatis 5 parts, ulva 22 parts, Radix Akebiae 13 parts, Nemacystus decipiens (Sur.) Kuck 24 parts, Radix urenae procumbentis 12 parts, Radix Bupleuri 31 parts, 28 parts, Flos Mume, Folium Citri tangerinae 14 parts, Caulis Perillae 23 parts, Radix aconiti sinomontani 6 parts, Lignum cinnamomi camphorae 18 parts and Radix Chloranthi Fortunei 12 parts.

5. the Chinese medicine as described in claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Japalurae 38 parts, Pelvetia siliquosa Tseng et C. F. Chang 34 parts, Rhizoma Dysosmae Versipellis 22 parts, Rhizoma Dioscoreae Nipponicae 13 parts, Sargassum 30 parts, Eucheuma gelatinosum 17 parts, Pumex 6 parts, Radix et Rhizoma Dysosmatis 8 parts, ulva 20 parts, Radix Akebiae 11 parts, Nemacystus decipiens (Sur.) Kuck 21 parts, Radix urenae procumbentis 14 parts, Radix Bupleuri 33 parts, 26 parts, Flos Mume, Folium Citri tangerinae 12 parts, Caulis Perillae 22 parts, Radix aconiti sinomontani 8 parts, Lignum cinnamomi camphorae 16 parts and Radix Chloranthi Fortunei 15 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps,

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 30 ~ 60 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 3 ~ 6 times obtained relative to the first step is the ethanol of 70 ~ 80%, and reflux 2 ~ 4 hours, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times again, each decoction 2 ~ 5 hours, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:

The first step, Japalurae, Pelvetia siliquosa Tseng et C. F. Chang, Rhizoma Dysosmae Versipellis, Rhizoma Dioscoreae Nipponicae, Sargassum, Eucheuma gelatinosum, Pumex, Lignum cinnamomi camphorae and Radix Chloranthi Fortunei are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 3 ~ 5 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into powder; Then add the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decoct 2 ~ 4 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to filtering residue quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;

3rd step, the powder mixing first step and second step obtained, add the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

8. the preparation method of Chinese medicine described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps,

The first step, is mixed in proportion described raw medicinal material, puts into marmite and fries 30 ~ 60 minutes, be ground into smalls, be screened into 100 order ~ 200 object powder with pulverizer;

Second step, the determining alcohol adding the powder quality 3 ~ 6 times obtained relative to the first step is the ethanol of 70 ~ 80%, and reflux 2 ~ 4 hours, extracts 2 ~ 3 times, merge extractive liquid, and filter and obtain alcohol extract, alcohol extract concentrating under reduced pressure, is recycled to without alcohol taste; The medicinal residues that filtration obtains add the distilled water relative to filtering residue quality 4 ~ 8 times again, each decoction 2 ~ 5 hours, decoct 2 ~ 3 times, filter respectively, merging filtrate obtains Aqueous extracts, Aqueous extracts concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract obtained above, further concentrating under reduced pressure, except desolventizing, drying, obtains and gets dry extract;

3rd step, is broken into 200 order ~ 400 object powder by described dried cream powder, add excipient and disintegrating agent mixing, drying, pulverize, add fluidizer, in finally incapsulating, obtain capsule in the powder obtained;

Described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate or other pharmaceutic adjuvants, and its weight content in described capsule is 10 ~ 50%;

Described disintegrating agent is sodium carboxymethyl cellulose or hydroxypropyl cellulose, and its weight content in described capsule is 5 ~ 20%;

Described fluidizer is magnesium stearate, differential silica gel or other there is the pharmaceutic adjuvant of fluidizer effect, its weight content in described capsule is 0.1 ~ 5%.

9. the preparation method of Chinese medicine described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is oral solutions, its preparation method comprises the following steps:

The first step, Japalurae, Pelvetia siliquosa Tseng et C. F. Chang, Rhizoma Dysosmae Versipellis, Rhizoma Dioscoreae Nipponicae, Sargassum, Eucheuma gelatinosum, Pumex, Lignum cinnamomi camphorae and Radix Chloranthi Fortunei are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 3 ~ 5 times of first step mixture quality;

Second step, is mixed in proportion surplus stock medical material, is ground into powder; Then add the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decoct 2 ~ 4 hours, filter, obtain the first filtrate; Filtering residue is added the distilled water relative to filtering residue quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;

3rd step, the powder mixing first step and second step obtained, add the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.