CN103893486A - Traditional Chinese medicine composition for treating liver cancer - Google Patents
Traditional Chinese medicine composition for treating liver cancer Download PDFInfo
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Abstract
The invention relates to a medicament for treating liver cancer and particularly relates to a traditional Chinese medicine composition prepared from plant Chinese herbal medicines as raw materials for treating liver cancer. The traditional Chinese medicine composition is characterized by comprising the following raw medicinal materials for preparing active ingredients are as follows by weight: 5g-15g of liquorice, 10g-20g of root of red-rooted salvia, 10g-20g of poria cocos, 10g-20g of white atractylodes rhizome, 10g-20g of radix paeoniae alba, 10g-20g of madder, 10g-20g of polygonum cuspidatum, 10g-20g of toosendan fruit, 10g-20g of lucid ganoderma, 10g-20g of pseudo-ginseng, 10g-20g of pangolin, 10g-20g of radix bupleuri, 10g-20g of peach kernel, 0.01g-0.05g of Chinese blister beetle, 15g-20g of semen boitae, 15g-20g of manyleaf paris rhizome, 15g-20g of porcellio scaber latreille and 15g-20g of turtle shell. The medicinal materials are combined to achieve the effects of detoxifying and removing stasis, activating meridians to stop pain, activating blood and dissipating stasis, and the like; the medicinal materials achieve a synergistic effect to improve and protect the body immune function while treating liver cancer, so that transfer and diffusion of cancer cells are obviously restrained, toxic and side effects are little, and operation is easy.
Description
Technical field
The present invention relates to a kind of medicine of Hepatoma therapy, especially relate to a kind of Chinese medicine composition of the Hepatoma therapy of making take vegetable Chinese herbal medicine as raw material.
Background technology
Hepatocarcinoma is one of modal malignant tumor clinically, global sickness rate increase year after year, and mortality rate is only second to the malignant tumor of gastric cancer, esophageal carcinoma.Initial stage symptom is not obvious, late period main manifestations be liver pain, weak, become thin, the symptom such as jaundice, ascites.The Etiological factor of China's hepatocarcinoma, has viral hepatitis to infect, the aflatoxin contamination in food, and contaminated drinking water etc. in rural area.At present, Hepatoma therapy be all in early days operation be main, be equipped with radiotherapy and chemotherapy.Operation no doubt can be excised cancerous protuberance, but also has in residual cancer or regional lymph node metastasis or blood vessel cancer embolus existence etc., and relapse and metastasis probability is very high.Radiochemotherapy complication is many, even causes many afunctions, and for late tumor patient, the effect of radiation therapy is not intact.Poor, the older patient of body constitution simultaneously, it is more critically ill that continuation radiotherapy can only be led debilitant life, accelerated death.Though chemotherapy has certain short term effect, Chang Yin is with significantly toxicity and side effect, and the catabasis is short, and life quality is poor, can not obviously extend patient's life cycle.Radiotherapy chemotherapy also can not kill all cancerous cell, and makes cancerous cell and human normal tissue cell simultaneously injured, and easily forms secondary tumor.Therefore, the present invention has particularly preferably adopted a kind of Chinese medicine composition of Hepatoma therapy.
Summary of the invention
Object of the present invention is exactly for liver cancer patient provides one targetedly, the Chinese medicine composition of the Hepatoma therapy of effective activity, therapeutic effect is good, effectively anticancer diffusion, can play the effect of attenuation synergistic, extend patient's life span, simultaneously obtained significant effect improving aspect cancer patient's quality of life.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Chinese medicine composition of Hepatoma therapy, it is characterized in that, the crude drug of making effective ingredient by following weight is: Radix Glycyrrhizae 5-15 gram, Radix Salviae Miltiorrhizae 10-20 gram, Poria 10-20 gram, Rhizoma Atractylodis Macrocephalae 10-20 gram, Radix Paeoniae Alba 10-20 gram, Radix Rubiae 10-20 gram, Rhizoma Polygoni Cuspidati 10-20 gram, Fructus Toosendan 10-20 gram, Ganoderma 10-20 gram, Radix Notoginseng 10-20 gram, Squama Manis 10-20 gram, Radix Bupleuri 10-20 gram, Semen Persicae 10-20 gram, Mylabris 0.01-0.05 gram, Semen Platycladi 15-20 gram, Rhizoma Paridis 15-20 gram, Armadillidium 15-20 gram, Carapax Trionycis 15-20 gram.
Pharmacological action
Radix Glycyrrhizae: sweet in the mouth, property is flat, nontoxic.Enter spleen, stomach, lung meridian.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature is nontoxic.GUIXIN, spleen two warps.Promoting blood circulation to restore menstrual flow, evacuation of pus granulation promoting, specially regulating menstruation arteries and veins, reason iliacus is ached, and tissue regeneration promoting blood, removes stagnant blood.Radix Salviae Miltiorrhizae can improve liver function, to hepatocarcinoma have certain anticancer, press down cancer, enhancing human body immunity function.
Poria: sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, strong lean marrow.The swelling of can harnessing the river is full, the diseases such as malignant histocytosis.Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach two warps.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, edema etc.The Rhizoma Atractylodis Macrocephalae can alleviate hepatic glycogen and reduce and hepatocellular degeneration necrosis, promotes hepatocyte to increase, and the ALT raising is declined, and the Rhizoma Atractylodis Macrocephalae can enhancing human body immunity function.
The Radix Paeoniae Alba: bitter in the mouth acid, cool in nature, be slightly cold.The easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, yin fluid astringing is received the effects such as antiperspirant.White peony root's total glycoside in the Radix Paeoniae Alba has protective effect to hepatocyte injury, and the phagocytic function of macrophage is had to potentiation, improves body immune system.
Radix Rubiae: mildly bitter flavor, cold in nature.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling.The stasis of blood in order to thin sharp Liver Channel is stagnant, improve the blood circulation of liver, promote hepatocellular recovery, Cyclohexapeptides class RA-III, RA-IV, RA-V and four activated monomers of RA-VII that Radix Rubiae contains have obvious active anticancer to cancer, and put forward effect in increasing leukocyte, prevent the leukopenia that the chemotherapeutics such as cyclophosphamide cause.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature.Return liver, gallbladder, lung meridian.Heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.The effects such as Rhizoma Polygoni Cuspidati has blood vessel dilating, infection, protects the liver, antiinflammatory, antioxidation, the resveratrol containing in Rhizoma Polygoni Cuspidati has therapeutical effect to hepatic injury.
Fructus Toosendan: bitter in the mouth, cold in nature, slightly poisonous.Return liver, small intestinal, urinary bladder channel.Soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic, the sedimentation of Fructus Toosendan bitter cold, mainly enters Liver Channel, catharsis liver-heat, promoting the circulation of QI to relieve pain, control the stagnation of QI and have the card of heat especially suitable.
Ganoderma: sweet in the mouth, property is flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, insomnia, dyspepsia, malignant tumor etc.; Animal pharmacology shows experiment: Ganoderma has hepatoprotective, improves immunologic function, effect such as antibacterial grade; Low or the imbalance of autoimmune function, is the major reason why tumor can occur and expand, and Ganoderma is that best immunologic function regulates and activator, and it can significantly improve the immunologic function of body, enhancing patient's self anti-cancer ability; Can be by promoting the generation of interleukin II, by the phagocytic function of promotion mononuclear phagocyte, by promoting the especially leukocytic index level of hematopoietic potential of human body, and pass through the wherein inhibitory action of some effective ingredient to cancerous cell, become the preferred agents of antitumor, anti-cancer and assistant treating cancer; The hepatic injury that multiple physics and chemistry and biological factor are caused has protective effect.No matter before liver injury occurs or after generation, taking Ganoderma all can the liver protecting, alleviates hepatic injury.Ganoderma can promote the metabolism of liver to medicine, poisonous substance, has definite curative effect for toxic hepatitis.Especially chronic hepatitis, Ganoderma can obviously be eliminated the symptoms such as dizziness, weak, nauseating, uncomfortable liver area, and can effectively improve liver function, makes indices be tending towards normal.
Radix Notoginseng: acrid in the mouth, warm in nature.Scattered silt hemostasis, subduing swelling and relieving pain, has effect of heat clearing away, suppressing the hyperactive liver, blood pressure lowering.Radix Notoginseng energy enhancing human body immunity function, antitumor, protects the liver antiinflammatory, can resist hepatocarcinoma, and liver is repaired in lasting protection.
Squama Manis: salty in the mouth, cold nature.Return liver, stomach warp.Blood circulation promoting and dispersing pathogen accumulation, the stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle is burst hard.Squama Manis blood stasis-eliminating and stagnation-dissipating, the contracting lump that disappears, has inhibitory action to malignant cell, can be anticancer.
Radix Bupleuri: hardship puts down, return through, enter liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver yang invigorating.Bupleurum chinense polysaccharide, can make body's immunity strengthen, anti-liver injury.
Semen Persicae: bitter in the mouth, sweet, property is flat.GUIXIN, liver, large intestine channel.Blood stasis removing and clots absorbing, moisturizes laxation, effect of the loose blood of slow liver.Hydrolyzate hydrocyanic acid and the benzaldehyde of the amygdalin containing in Semen Persicae, have collaborative destruction to cancerous cell.Amygdalin can help the mucoprotein tunicle of transparent sample of body endotrypsin digestion cancerous cell, make leukocyte can approach cancerous cell, so that engulf cancerous cell, the further metabolite of its hydrolyzate hydrocyanic acid and benzaldehyde, also has certain effect to improving patient's anemia and relaxing the pain of tumour patient respectively.
Mylabris: acrid in the mouth, cold in nature, very toxic.Return liver, kidney, stomach, large intestine, small intestine meridian.The removing blood stasis wei that disappears, merit poison phagedenoma, removing blood stasis eliminating stagnation, draws red foaming.Mylabris main component contains cantharidin, formic acid, waxiness etc., and its pharmacological action has antitumor action: Mylabris extract can suppress the metabolism of human esophagus cancer, carcinoma of gastric cardia, gastric cancer, pulmonary carcinoma and sarcoma of spleen cell in vitro; Can resist the rising of hepatic injury and GPT due to carbon tetrachloride.
Semen Platycladi: sweet in the mouth, property is flat, nontoxic.Enter the heart, liver, spleen channel.Nourish conscience, tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Middle medical circles generally believe that the function of Semen Platycladi is nourishing the liver mind calming, the arresting sweating of calming the nerves.
Rhizoma Paridis: bitter in the mouth is pungent, cold in nature, poisonous.Enter the heart, Liver Channel.Heat-clearing and toxic substances removing, antiasthmatic-antitussive, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.Rhizoma Paridis is the product that hardship is let out removing toxic substances, can removing summer-heat liver and gall hot and suffocating, the sending down the abnormal ascending QI that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., also can detumescent expectorant, diuretic dries.
Armadillidium: sour in the mouth is salty, warm in nature, nontoxic.Return liver, kidney channel.Removing blood stasis with potent drugs eliminating mass, removing toxic substances pain relieving, removing blood stasis diuretic.Armadillidium can be used for the severe pain of Hepatoma therapy.
Carapax Trionycis: salty in the mouth, is slightly cold.Return liver, kidney channel.Nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.Carapax Trionycis has a lot of effects, can suppress the connective tissue proliferation of liver, spleen; Improve plasma protein level; There is certain antitumor action; Can improve immunologic function, can form by Promote immunity globulin, extend antibody life period, can suppress animal connective tissue's hypertrophy; Hepatic injury is had to protective effect, and the anemia that hepatic injury is caused has mitigation, and can promote the synthetic of the interior albumen of liver, increases the content of plasma albumin; Hepatoma carcinoma cell is had to inhibitory action; Be used for the treatment of the low grade fever that the diseases such as chronic infection, tuberculosis, tumor cause; Treatment chronic hepatitis, early stage liver cirrhosis, hepatosplenomegaly; For after tumor operation, after radiotherapy, continual cure is with right supporting anticancer.
The invention has the beneficial effects as follows, the present invention, by after said medicine combination, has detoxicating and resolving stagnation of pathogens; removing obstruction in the collateral to relieve pain, promoting blood circulation to remove blood stasis, stasis-dispelling and pain-killing; removing heat from blood detumescence, suppressing the hyperactive liver pathogenic fire purging, the effect such as antipyretic reason is wet; drug effect synergism; in Hepatoma therapy, improve and protect body's immunity, obviously suppress transfer and the diffusion of cancerous cell; toxic and side effects is few, easy operating.
This experiment intends observing the acute toxic reaction of mice to this Chinese medicine preparation, is reported as follows:
Data and method
The mice in age in laboratory animal: 6-8 week, body weight is at 20 ± 2g, and 30, male and female half and half.
Acute toxicity testing: select 10 of Kunming kind white mice, male and female half and half, body weight 20 ± 2g.Fasting, can't help water 12-16 hour.Select certain proportion medicine, wash, then use cold water soak 20-30 minute, medicine is flooded completely, add the water doubly into medicine 5-10, or exceed 2-3 centimetre of left and right than powder.While decocting first pass, while being heated to 100 ℃ of left and right with big fire, use little fire heating 20 minutes instead all right, medicine soup is poured in vessel, then decocts second time, the method for decocting second time is the same with first pass, the medicine soup of decocting for twice is mixed and boils concentrated 3 times again, and reaching content of dispersion is 425mg/ml.Every each gavage of mice gives this traditional Chinese medicine liquid 5ml/20g(body weight that concentration is pastille 425mg/ml), gavage 2 times in 24h, 6 hours, interval, then observes the situations such as mice outward appearance, behavioral activity, breathing, secretions, defecation, death and weighs continuous 7 days.Because being treated the impact of cancer root drug level and volume, single administration is not all measured median lethal dose(LD 50) (LD50) with Cmax, heap(ed) capacity.
Maximum dosage-feeding experiment: select 20 of Kunming kind white mice, male and female half and half, body weight 20 ± 2g, according to acute toxicity testing method make up a prescription, gavage, observation, detection.After 7 days, mice is weighed, dissect, and case control important organ (heart, liver, spleen, lung, kidney), and calculate maximum dosage (g/Kg.d) in mice 1 day.
Experiment conclusion
Do not measure this Chinese medicine median lethal dose(LD 50) (LD50) with Cmax, heap(ed) capacity, therefore only do maximum dosage-feeding experiment.Chinese medicine mice maximum dosage-feeding is that 26.89 g/Kg.d(amount to crude drug and calculate), be equivalent to 13 times of the clinical daily dosage of people's (body weight is calculated according to 60Kg).It is dead that all administration mices have no, and also do not find the clinical manifestation that other are relevant with administration, illustrates that this medicine is nontoxic, and the clinical application amount of this medicine is safe dose.
Pharmacodynamics test:
The present invention is through pharmacodynamics test, efficacy stability of the present invention, safe and reliable.
The present invention has significant inhibitory action to the growth of human liver cancer cell, and in vitro tests shows that its human liver cancer cell HepG2 to In vitro culture is inhibited, can promote the apoptosis of hepatoma carcinoma cell HepG2.
The present invention has protective effect to liver, and in vitro tests shows that it can alleviate BCG and add LPS immunity and damage the destruction to mouse liver pathologic structure, protects its liver function.
Below in conjunction with clinical experiment data declaration beneficial effect of the present invention.
Selecting 442 routine liver cancer patients is example.
Diagnostic criteria
Western medicine diagnose standard: the primary hepatic carcinoma diagnosis standard in " the Chinese common cancer diagnosis and treatment standard " compiled take China's Ministry of Public Health is as foundation.
Tcm diagnosis standard: with reference to " new drug (Chinese medicine) treatment primary hepatocarcinoma clinical guidance principle " medicine typing standard, distinguish as blood stasis liver depression.
Case inclusive criteria
(1) clarify a diagnosis as the patient of primary hepatocarcinoma;
(2) differential diagnosis in tcm is the patient of blood stasis stagnation of liver-QI pattern of syndrome;
(3) Karnofsky marks more than 40 points, estimates more than 2 months person life cycle;
(4) age is the 25-65 patient in year.
Therapeutic Method
Take Chinese medicine composition of the present invention, be decocted in water for oral dose, every day, potion, divided one after each meal sooner or later, within 20 days, was a course for the treatment of.
Curative effect determinate standard
(1) variation of tumor size
According to primary hepatocarcinoma efficacy assessment standard in Ministry of Public Health " Chinese common cancer diagnosis and treatment standard ", with before patient treatment with treatment after B ultrasonic or CT compare, alleviating completely, partial rcsponse, stable, carry out efficacy evaluation.
(2) tcm syndrome (before and after treatment, observation once, compares respectively)
Recovery from illness: symptom, sign obviously disappear;
Effective: symptom, sign are obviously improved, syndrome integration reduces >=70%;
Effective: symptom, sign are obviously improved, syndrome integration reduces >=30%;
Invalid: symptom, sign are not improved, syndrome integration reduces less than 30%.
Computing formula: [integration before (the rear integration of integration-treatment before treatment)/treatment] × 100%.
Interpretation of result
Tumor size evaluation result before and after treatment, in table 1.
Table 1
From table 1, Chinese medicine of the present invention is 90.1% to the effective percentage of Hepatoma therapy, illustrates that the effective percentage of Hepatoma therapy of the present invention is high, has the development of the hepatocarcinoma of inhibition, the effect of stablizing tumor body.
Toxic and side effects is analyzed
In the 442 routine patients that observe, only there are 6 examples to occur low grade fever after taking Chinese medicine of the present invention, 5 routine laxativeness, the probability that occurs side reaction is only 2.49%, through disposing to the ill loss for reaction, all the other are without any side effects.
In sum, the present invention is used for the treatment of hepatocarcinoma, through clinical experiment, shows that it can effectively suppress hepatocarcinoma development, improves patient's symptom, sign, and without obvious toxic-side effects.
Case is as follows
Jiang, man, 60 years old, slack tide people from town, Tongzhou District, Nantong City, patient's symptom is that abdominal part is vexed swollen, and dyspepsia is sometimes felt sick, vomitted the heating of unknown cause, hepatic region rest pain, is diagnosed as hepatocarcinoma, finds that through abdominal CT inspection tumor size is 3cm × 4cm.The symptoms such as through taking Chinese medicine composition of the present invention, every day, potion, was decocted in water for oral dose, and a point morning and evening takes, and 20 days is a course for the treatment of, takes after 3 courses for the treatment of, and patient's abdominal part is vexed swollen, generates heat, nauseating obviously alleviate, and appetite increases, and on inspection, tumor is reduced into 2cm × 3cm, and sb.'s illness took a favorable turn.
Hu, female, 55 years old, people from Tongzhou District, Nantong City, patient body checks out that there is tumor in liver, the about 2-4 centimetre of radius, and with weak, become thin, the symptoms such as abdominal distention, are diagnosed as primary hepatocarcinoma middle and late stage through hospital, and patient adopts expectant treatment.Through taking Chinese medicine composition of the present invention, every day, potion, was decocted in water for oral dose, and a point morning and evening takes, and within 20 days, is a course for the treatment of, after 2 courses for the treatment of, checks, tumor obviously reduces, and takes medicine continuously after 5 courses for the treatment of, went examination in hospital to find that tumor disappears, and followed up a case by regular visits to so far not recurrence.
Try to gain certain, man, 63 years old, people from Nantong City, in the hepatocarcinoma later stage, every day, potion, was decocted in water for oral dose, and within 20 days, was a course for the treatment of, after 5 courses for the treatment of, checked, and tumor obviously reduces.
Wang, man, 45 years old, people from Tongzhou District, Nantong City, patient body checks out that there is tumor in liver, is early hepatocarcinoma, through taking Chinese medicine composition of the present invention, every day, potion, was decocted in water for oral dose, and within 20 days, was a course for the treatment of, took after 3 courses for the treatment of, went examination in hospital to find that tumor disappears.
The specific embodiment
In order to understand better and to implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take 12 grams, Radix Glycyrrhizae, 20 grams of Radix Salviae Miltiorrhizaes, 20 grams, Poria, 20 grams of the Rhizoma Atractylodis Macrocephalaes, 18 grams of the Radix Paeoniae Albas, 18 grams, Radix Rubiae, 18 grams of Rhizoma Polygoni Cuspidati, 18 grams of Fructus Toosendans, 18 grams of Ganodermas, 18 grams, Radix Notoginseng, 18 grams of Squama Maniss, 18 grams of Radix Bupleuri, 18 grams, Semen Persicae, 0.05 gram of Mylabris, 20 grams of Semen Platycladi, 20 grams of Rhizoma Paridis, 20 grams of Armadillidium, 20 grams of Carapax Trionycis.Make Chinese medicine decoction according to conventional method.
Embodiment 2
Preferably take 10 grams, Radix Glycyrrhizae, 15 grams of Radix Salviae Miltiorrhizaes, 15 grams, Poria, 15 grams of the Rhizoma Atractylodis Macrocephalaes, 15 grams of the Radix Paeoniae Albas, 15 grams, Radix Rubiae, 15 grams of Rhizoma Polygoni Cuspidati, 15 grams of Fructus Toosendans, 15 grams of Ganodermas, 15 grams, Radix Notoginseng, 15 grams of Squama Maniss, 15 grams of Radix Bupleuri, 15 grams, Semen Persicae, 0.03 gram of Mylabris, 18 grams of Semen Platycladi, 18 grams of Rhizoma Paridis, 18 grams of Armadillidium, 18 grams of Carapax Trionycis.Make Chinese medicine decoction according to conventional method.
Embodiment 3
Further preferably take 6 grams, Radix Glycyrrhizae, 12 grams of Radix Salviae Miltiorrhizaes, 12 grams, Poria, 12 grams of the Rhizoma Atractylodis Macrocephalaes, 12 grams of the Radix Paeoniae Albas, 12 grams, Radix Rubiae, 12 grams of Rhizoma Polygoni Cuspidati, 12 grams of Fructus Toosendans, 11 grams of Ganodermas, 11 grams, Radix Notoginseng, 12 grams of Squama Maniss, 12 grams of Radix Bupleuri, 12 grams, Semen Persicae, 0.01 gram of Mylabris, 15 grams of Semen Platycladi, 15 grams of Rhizoma Paridis, 15 grams of Armadillidium, 15 grams of Carapax Trionycis.Make Chinese medicine decoction according to conventional method.
First medicine is washed, use again cold water soak 20-30 minute, medicine is flooded completely, be convenient to the dissolving of effective ingredient, then medicine is placed in the vessel of marmite, pottery or crock and so on (cannot use iron pan and aluminum pot), adds the water doubly into medicine 5-10.Or exceed 2-3 centimetre of left and right than powder.While decocting first pass, while being heated to 100 ℃ of left and right with big fire, use little fire heating 20 minutes instead all right, medicine soup is poured in vessel, decoct second time, the method for decocting second time is the same with first pass again, and just the time can be shorter a little, after having decocted, this twice fried medicine soup is mixed and taken, and total amount is at 300-500 milliliter, and patient can take for one day at twice, for the difficult patient that takes traditional Chinese medicine, can be on a small quantity sub-service repeatedly.
Usage: be decocted in water for oral dose, patient can take for one day at twice, for the difficult patient that takes traditional Chinese medicine, can be on a small quantity sub-service repeatedly.
Points for attention: period in a medicine avoids pungent food, cold and cool, raw and cold food.
The present invention can be made into unguentum, powder, electuary, tablet, granule, pill, capsule, oral liquid.
Claims (4)
1. the Chinese medicine composition of a Hepatoma therapy, it is characterized in that, the crude drug of making effective ingredient by following weight is: Radix Glycyrrhizae 5-15 gram, Radix Salviae Miltiorrhizae 10-20 gram, Poria 10-20 gram, Rhizoma Atractylodis Macrocephalae 10-20 gram, Radix Paeoniae Alba 10-20 gram, Radix Rubiae 10-20 gram, Rhizoma Polygoni Cuspidati 10-20 gram, Fructus Toosendan 10-20 gram, Ganoderma 10-20 gram, Radix Notoginseng 10-20 gram, Squama Manis 10-20 gram, Radix Bupleuri 10-20 gram, Semen Persicae 10-20 gram, Mylabris 0.01-0.05 gram, Semen Platycladi 15-20 gram, Rhizoma Paridis 15-20 gram, Armadillidium 15-20 gram, Carapax Trionycis 15-20 gram.
2. the Chinese medicine composition of Hepatoma therapy according to claim 1, is characterized in that, the crude drug of making effective ingredient by following weight is: 12 grams, Radix Glycyrrhizae, 20 grams of Radix Salviae Miltiorrhizaes, 20 grams, Poria, 20 grams of the Rhizoma Atractylodis Macrocephalaes, 18 grams of the Radix Paeoniae Albas, 18 grams, Radix Rubiae, 18 grams of Rhizoma Polygoni Cuspidati, 18 grams of Fructus Toosendans, 18 grams of Ganodermas, 18 grams, Radix Notoginseng, 18 grams of Squama Maniss, 18 grams of Radix Bupleuri, 18 grams, Semen Persicae, 0.05 gram of Mylabris, 20 grams of Semen Platycladi, 20 grams of Rhizoma Paridis, 20 grams of Armadillidium, 20 grams of Carapax Trionycis.
3. the Chinese medicine composition of Hepatoma therapy according to claim 1, is characterized in that, the crude drug of making effective ingredient by following weight is: 10 grams, Radix Glycyrrhizae, 15 grams of Radix Salviae Miltiorrhizaes, 15 grams, Poria, 15 grams of the Rhizoma Atractylodis Macrocephalaes, 15 grams of the Radix Paeoniae Albas, 15 grams, Radix Rubiae, 15 grams of Rhizoma Polygoni Cuspidati, 15 grams of Fructus Toosendans, 15 grams of Ganodermas, 15 grams, Radix Notoginseng, 15 grams of Squama Maniss, 15 grams of Radix Bupleuri, 15 grams, Semen Persicae, 0.03 gram of Mylabris, 18 grams of Semen Platycladi, 18 grams of Rhizoma Paridis, 18 grams of Armadillidium, 18 grams of Carapax Trionycis.
4. the Chinese medicine composition of Hepatoma therapy according to claim 1, is characterized in that, the crude drug of making effective ingredient by following weight is: 6 grams, Radix Glycyrrhizae, 12 grams of Radix Salviae Miltiorrhizaes, 12 grams, Poria, 12 grams of the Rhizoma Atractylodis Macrocephalaes, 12 grams of the Radix Paeoniae Albas, 12 grams, Radix Rubiae, 12 grams of Rhizoma Polygoni Cuspidati, 12 grams of Fructus Toosendans, 11 grams of Ganodermas, 11 grams, Radix Notoginseng, 12 grams of Squama Maniss, 12 grams of Radix Bupleuri, 12 grams, Semen Persicae, 0.01 gram of Mylabris, 15 grams of Semen Platycladi, 15 grams of Rhizoma Paridis, 15 grams of Armadillidium, 15 grams of Carapax Trionycis.
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| CN107929368A (en) * | 2018-01-17 | 2018-04-20 | 孙显林 | A kind of Chinese medicine composition and its preparation for treating myoneural pain, pain caused by cancer |
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| CN1698684A (en) * | 2004-05-19 | 2005-11-23 | 钟伟 | Anticancer tumour extinguishing toxin expelling decoction |
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| CN1698684A (en) * | 2004-05-19 | 2005-11-23 | 钟伟 | Anticancer tumour extinguishing toxin expelling decoction |
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| CN107929368A (en) * | 2018-01-17 | 2018-04-20 | 孙显林 | A kind of Chinese medicine composition and its preparation for treating myoneural pain, pain caused by cancer |
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