CN103735835B - A kind of Chinese medicine preparation for the treatment of young person with greying hair and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of young person with greying hair's for the treatment of Chinese medicine preparation, in described preparation, the parts by weight of various bulk drugs are: 10～20 parts of barrenwort, 10～20 parts of Radix Codonopsis, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the fruit of glossy privets, 10～20 parts of semen astragali complanatis, 10～20 parts of walnut kernel, 10～20 parts of oriental wormwoods, 10～20 parts of the fruits of Chinese wolfberry, 10～20 parts of mulberries, 10～20 parts of the seed of Chinese dodders, 10～20 parts of cacumen biotaes, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of sealworts, 10～20 parts of Fructus Cornis, 10～20 parts of the reds sage root, 10～20 parts of the root of herbaceous peonys, 10～20 parts, the fruit of Chinese magnoliavine, 10～20 parts of Eclipta prostratas, 10～20 parts of rhizoma cyperis. the present invention is activating QI to alleviate the depression, flat liver kidney tonifying, disinfection, inrigorating qi and promoting blood circulation, reaches pore and pauses out, nutrition scalp, the Chinese medicine preparation of blacking hair and nourishing face. it has the effect that has special hair restoration crow to send out to young person with greying hair, neurasthenia alopecia etc.

Description

A kind of Chinese medicine preparation for the treatment of young person with greying hair and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, relate to especiallyAnd a kind of Chinese medicine preparation for the treatment of young person with greying hair and preparation method thereof.

Background technology

Determine hair color be in hair pigment granule number, the latter and root of hair nipple are chromatophorousDevelopment growth situation is relevant. Hair is bleached by black, is generally the chromatophore deterioration of hair, when decliningFall back on completely can not chromogenesis particle time, hair has just bleached completely. Normal person is since 35 years old, hairSending out chromatophore falls into a decline. And next year old of somebody 20 is just white, medically claim juvenile canities, be commonly called as " fewHoary hair ". Blood-head, kidney qi deficiency are weak, qi and blood is weak is all the reason that causes white hair. The source of nutrition of hairIn blood, if hair bleaches or comes off, be because of deficiency of liver-blood, a little less than kidney qi deficiency mostly. Therefore, the traditional Chinese medical scienceMethods for the treatment of be tonifying liver blood, kidney tonifying gas.

Chinese traditional treatment white hair according to theory of traditional Chinese medical science is: " liver storing blood, hair is the sign of blood condition ", " kidney controlling essence storage,Its Hua Fa ", " heart governing blood and vessels ", " lung governing skin and hair ". " spleen is source of generating QI and blood ". That is to say hairGrowth and color and luster change, with the function prosperity and decline of the vital organs of the human body, yang-energy essence and blood warm moisten support closely bound up.If internal organs function is vigorous, yang-energy essence and blood is full, and hair is fully moistened supports that black profit is beautiful, is difficult for de-mistake.On the contrary, if inadequate natural endowment, lose foster the day after tomorrow, internal organs function weakness, and negative and positive of qi and blood virtual loss, is difficult the hair of supplementing nutritionSend out early life of white hair, sparse easy to break. And it is wherein more close with the relation of spleen, kidney, liver. All congenitalFoot, deficiency of kidney-essence, marrow lose the person of filling less, or edgy, blood-head is contained partially, impairment of yin hematozemia person, or worriedPonder over, the dysfunction of the spleen in transport, the weary source person of qi and blood, or excessive thinking and anxiety, insomnia and dreamful sleep, secretly consumption person of liver blood, all canInjure the five internal organs, deficient qi and blood, loses hair foster and early white.

Young person with greying hair's generation, except heredity is innate factor cannot change, other factors are by rationally regulatingCan change. Doctor trained in Western medicine is referred to as presenile poliosis, is a kind of children and nonage white hair diseaseDisease, its cause of disease is very complicated, has two large types, the congenital young person with greying hair of a kind, another kind day after tomorrowProperty young person with greying hair. In posteriority young person with greying hair, having many is to follow certain disease pathogenetic, some be due toDue to the overstretched and malnutrition of spirit.

Posteriority young person with greying hair. The reason causing is a lot: malnutrition, as lack protein, vitamin withAnd some trace element (as copper) etc., all can make hair bleach; Some chronic wasting disease is as tuberculosisSick etc., because causing nutritional deficiency, hair also obtains earlier than the white of common people; The disease of some long-term feversPeople, hair meeting Huang is crisp even to bleach and comes off; Some endocrine system diseases, as pituitary or thyroid gland illness,Can affect the ability of chromatophore chromogenesis particle and cause hair to bleach too early; Encephalitis, nervous systemPathologies etc. also can make hair bleach; Albinism patient's skin, hair, eyebrow are all white; Skin becomesWhite disease-" leucoderma ", as occur on scalp, hair also can bleach; Somebody thinks, requires mental skillMore, hair Bai get Yue early; At short notice, hair bleaches some young man in a large number, with excessive JiaoThe serious mental wound such as worry, sadness or spirit are overtired relevant.

As for congenital presenile poliosis mostly because heredity causes, as early chronic illness, cotton material of the property lostCotard, Wardenburg Cotard often have number hereditary history of generation in family, hereditary detect,Albinism also belongs to congenital hereditary disease. Removing acquired is that posteriority local skin disease is through several months and several years extremelyOutside majority can recover normally, the cause of disease of these presenile poliosis is all because genetic gene mutation causes machineDue to being obstructed in body tyrosine metabolic pathway whole (as albinism) or part.

If find in children and youth, young person with greying hair should check to hospital early, makes a definite diagnosis its pathogenesis etiologyAfter, as long as the cause of disease is eradicated, can cure young person with greying hair. There is in the market white hair and hair tonicProduct and the medicine of function are a lot, but for Western medicine, great majority use steroids product, and the one,Price comparison costliness, continues to use several courses for the treatment of, brings very large financial burden to client patient, and the 2nd,Long-time use easily brought certain side effect to physical function; For the pure Chinese medicine on market, drug effectSlow, formula compatibility is bad, unstable again. Needs of patients has and has hair-blackening tonic, can use for a long time,Effective, to be free from side effects again, cheap Chinese herbal medicine formula preparation solves the good of young person with greying hair's problemSide.

Summary of the invention

Technical problem to be solved by this invention is, for having in the market, crow sends out, the merit of hair tonicProduct and the medicine of energy are a lot, and for Western medicine, great majority use hormone medicines, the one, cost ratiosMore expensive, continue to use several courses for the treatment of, bring very large financial burden to client patient; The 2nd, long-timeUse and easily bring certain side effect to physical function. These product curative effects are very micro-, and classifyMany, treated effect is low, and cost is compared with high and the course for the treatment of is longer, and what have also occurs macula, even scalp skinBubble, make ward mate produce fear. And Chinese medicine takes effect slowly, effect is not remarkable, there is no specific aim. ThisThe bright liver-kidney tonifying of taking, the inducing resuscitation of having one's ideas straightened out, activating QI to alleviate the depression, flat liver kidney tonifying, disinfection, inrigorating qi and promoting blood circulationCompatibility of drugs, reaches blackening and generating hair, nutrition scalp, the Chinese medicine preparation of the object of hair regeneration. The present inventionTo each active ingredient science compatibility of component medicine, be a kind of instant effect, without any side effects, effectContinue Chinese medicine preparation of a specified duration, the upper misery that solves patient largely.

For solving the problems of the technologies described above, the invention provides a kind of young person with greying hair's for the treatment of Chinese medicine preparation, described systemIn agent, the parts by weight of various bulk drugs are: 10～20 parts of barrenwort, and 10～20 parts of Radix Codonopsis, RADIX POLYGONI MULTIFLORI PREPARATA 10～20 parts, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the fruit of glossy privets, 10～20 parts of semen astragali complanatis, walnut kernel 10～20Part, 10～20 parts of oriental wormwoods, 10～20 parts of the fruits of Chinese wolfberry, 10～20 parts of mulberries, 10～20 parts of the seed of Chinese dodders, side10～20 parts of CedarLeaves, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of sealworts, 10～20 parts of Fructus Cornis, the red sage root 10～20 parts, 10～20 parts of the root of herbaceous peonys, 10～20 parts, the fruit of Chinese magnoliavine, 10～20 parts of Eclipta prostratas, 10～20 parts of rhizoma cyperis.

Described treatment young person with greying hair's Chinese medicine preparation, described in it, in preparation, the parts by weight of various bulk drugs are passableFor: 10～15 parts of barrenwort, 10～15 parts of Radix Codonopsis, 10～15 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～15 parts of Radix Angelicae Sinensis, female10～15 parts of loyal sons, 10～15 parts of semen astragali complanatis, 10～15 parts of walnut kernel, 10～15 parts of oriental wormwoods, the fruit of Chinese wolfberry10～15 parts, 10～15 parts of mulberries, 10～20 parts of the seed of Chinese dodders, 10～20 parts of cacumen biotaes, the dried rhizome of rehmannia 10～20Part, 10～20 parts of sealworts, 10～20 parts of Fructus Cornis, 10～20 parts of the reds sage root, 10～20 parts of the root of herbaceous peonys, the five tastes10～20 parts of sons, 10～20 parts of Eclipta prostratas, 10～20 parts of rhizoma cyperis.

Described treatment young person with greying hair's Chinese medicine preparation, described in it, in preparation, the parts by weight of various bulk drugs also canThink: 10～20 parts of barrenwort, 10～20 parts of Radix Codonopsis, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 10～20 parts of Radix Angelicae Sinensis,10～20 parts of the fruit of glossy privets, 10～20 parts of semen astragali complanatis, 10～20 parts of walnut kernel, 10～20 parts of oriental wormwoods, matrimony vine10～20 parts of sons, 10～20 parts of mulberries, 10～15 parts of the seed of Chinese dodders, 10～15 parts of cacumen biotaes, the dried rhizome of rehmannia 10～15 parts, 10～15 parts of sealworts, 10～15 parts of Fructus Cornis, 10～15 parts of the reds sage root, 10～15 parts of the root of herbaceous peonys, five10～15 parts of tastes, 10～15 parts of Eclipta prostratas, 10～15 parts of rhizoma cyperis.

For solving the problems of the technologies described above, the present invention also provides the preparation of a kind of young person with greying hair's for the treatment of Chinese medicine preparationMethod, the process for producing granula of described Chinese medicine preparation comprises the following steps:

A, get raw material and put into water and soak, heat is extracted 2 times, becomes paste, is component 1;

B, the dregs of a decoction add alcohol extract 2 times, and thickening filtration is paste, are component 2;

C, above-mentioned two kinds of pastes are condensed into pasty state add dextrin or honey to granulate, sterilizing.

In described step a, can get in the water that described bulk drug adds 5-10 doubly to measure and soak 1-2 hour, addHeat is extracted 2 times, and each 1-2 hour, removes supernatant, merges extract, and 100-120 order filters, then warpThe molecular weight that dams is the ultrafiltration post ultrafiltration of 5000-10000, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C1.36 medicinal extract, heating is concentrated into paste, and stand for standby use, becomes component 1.

In described step b, the dregs of a decoction that alcohol extract can be crossed are put into 10 times of amount ethanol, add hot refluxExtract 2 times, each extraction time is 1～2 hour, and 100-120 order filters, then through the molecular weight that dams isThe ultrafiltration post ultrafiltration of 5000-10000,1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 DEG C,Heating is concentrated into paste, and stand for standby use, becomes component 2.

In described step c, above-mentioned two kinds of component pastes can be condensed into pasty state, add honey or dextrin and adjustWith after put into granulator, after granulating with ultraviolet disinfection, then pack.

For solving the problems of the technologies described above, the present invention provides the preparation of a kind of young person with greying hair's for the treatment of Chinese medicine preparation againMethod, the preparation process that described Chinese medicine preparation is pill is: first described bulk drug is dropped into multi-functional extractionTank extracts twice, adds for the first time 8-10 times of water gaging and decocts 1-2 hour, adds for the second time 4-8 times of water gaging and decocts 1-2Hour, merge twice decocting liquid, filter to get filtrate; Decompression is put into inspissator and is concentrated into pasty state, puts into baking ovenCooling after 80 DEG C of oven dry, grind to form fine powder, call in honey and make honey refining pill, bottling.

Above-mentioned steps decompression is put into inspissator when concentrated, and what while being concentrated into 90 DEG C, relative density was 1.05 is denseContracting liquid, set to 0～5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filters,Filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.

Described treatment young person with greying hair's Chinese medicine preparation, the formulation of Chinese medicine preparation for the treatment of young person with greying hair described in it is passableFor: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid,Suck agent, granule, electuary, pill, powder, sublimed preparation, solution, injection, suppository, plasterAgent or creme.

The present invention has liver-kidney tonifying, the inducing resuscitation of having one's ideas straightened out, activating QI to alleviate the depression, flat liver kidney tonifying, disinfection, benefitGas is invigorated blood circulation, and reaches blacking hair and nourishing face, pore pauses out, nutrition scalp, the advantage of hair regeneration. The present invention canGive full play to medicine greatest treatment efficacy, there is security good, the advantage that feasibility is good, compared with prior artReligion, this technology has convenient drug administration, through patient part, targeting is strong, and medicament is easy to manufacture, costThe advantage such as cheap. The present invention adopts the Chinese medicine of different properties, has carried out science compatibility, can reach desirableResult for the treatment of, and safety, without any side effects, easy to use, after curing, be difficult for recurrence, and valencyLattice are cheap, easy to use, can create good social value and economic interests.

Detailed description of the invention

Scientist studies discovery in recent years, contains the mixture of copper and iron in the pigment granule of hair, when blackWhen look hair nickel content increases, hair will become canescence; In flavous hair, contain titanium; RussetIn the hair of look, contain molybdenum; In henna hair, except containing copper, also contain titanium. As can be seen here, micro-The color of secondary element and hair has substantial connection. In order to prevent young person with greying hair's too early appearance, should on dietNote the food of taking in iron content and copper more. The food that iron content is many have Animal Liver, eggs, black fungus, sea-tangle,Soybean, sesame paste etc.; The food that cupric is many have Animal Liver, kidney, shrimp crab class, hard fruit, apricot paving dry andDry bean etc. Note the absorption of B family vitamin. Physician now confirms, the B1 that is deficient in vitamin, B2,B6 is also a major reason that causes young person with greying hair. Should increase the absorption of this group food, as cereal, beansClass, dry fruit, Animal Liver, the heart, kidney, milk, eggs and leaf vegetables etc.

Young person with greying hair patient is also noted that the food that is rich in tyrosine of taking in more. Melanic forming process, isFormed by the mould oxidation tyrosine of tyrosine. That is to say, the basis that melanin forms is tyrosine, junketPropylhomoserin lacks also can cause young person with greying hair. Therefore, should take in the food abundant containing tyrosine more, as chicken,Lean beef, thin pork, rabbit meat, fish and hard fruit food etc.

The source of nutrition of hair, in blood, if hair bleaches or comes off, is because of deficiency of liver-blood mostly, kidneyA little less than the deficiency of vital energy. Therefore, the methods for the treatment of of the traditional Chinese medical science is tonifying liver blood, kidney tonifying gas. Blood-head, kidney qi deficiency are weak, qi and bloodWeak is all the reason that causes white hair. According to theory of traditional Chinese medical science be: " liver storing blood, hair is the sign of blood condition ", " kidneyMain store essential substances, its Hua Fa ", " heart governing blood and vessels ", " lung governing skin and hair ". " spleen is source of generating QI and blood ". AlsoBe to say that the growth of hair and color and luster change, with the function prosperity and decline of the vital organs of the human body, it is foster that yang-energy essence and blood warm moistenedClosely bound up. If internal organs function is vigorous, yang-energy essence and blood is full, and hair is fully moistened supports that black profit is beautiful,Be difficult for de-mistake. On the contrary, if inadequate natural endowment, lose foster the day after tomorrow, internal organs function weakness, and negative and positive of qi and blood virtual loss,Being difficult to supplement nutrition, white hair is early raw, sparse easy to break for hair. And it is wherein more close with the relation of spleen, kidney, liver.All inadequate natural endowments, deficiency of kidney-essence, marrow lose the person of filling less, or edgy, blood-head is contained partially, impairment of yin hematozemia person,Or sorrow is pondered over, the dysfunction of the spleen in transport, the weary source person of qi and blood, or excessive thinking and anxiety, insomnia and dreamful sleep, secretly consumption person of liver blood,All can injure the five internal organs, deficient qi and blood, loses hair foster and early white.

The traditional Chinese medical science thinks that white hair appears in teenager too early, often ponders over because of sorrow, in blood-head, accumulate, send out become homeless support andBecome. Controlling should heat clearing and blood cooling, nourishing liver and kidney method, traditional Chinese medicine thinks, this disease be mainly due to liver kidney notDue to foot, deficiency of vital energy and blood. Geneogenous young person with greying hair is how relevant with heredity, is difficult for treatment; And it is posteriorityYoung person with greying hair, except according to etiological treatment, also should strengthen nutrition. Experiment shows, lacks protein and heightDegree malnutrition is one of cause of disease of early raw white hair. In diet, lacking trace copper, cobalt, iron etc. also canCause white hair. In addition also have the numerous disease all may be with the appearance of presenile white hair, as pernicious anaemia,Hyperthyroidism, angiocardiopathy (miocardial infarction, atrioventircular bundle block, hypertension etc.),Steinert's disease, leucoderma and Vogt-Koyanagi Cotard etc. In addition, human body spiritThe change of state, as long-term depression is joyous, troubled thoughts are excessive or mood is overstretched, often can cause in terror hairSend out and bleach rapidly. The factor of above-mentioned disease and nutrition and spirit can make vigour, pectoral qi, ying-qi three loseBalance, thus make damaged hair, Here it is we " having hindered vigour " of often saying in word. This presenileWhite hair, without special treatment, only need find the cause of disease and eradicate it, can effect a radical cure.

In numerous reasons, the traditional Chinese medical science thinks that topmost reason is suffer from a deficiency of the kidney lung damage, toxin accumulation, trace aboveElement lacks, and causes alopecia. The present invention sums up the cause of disease of forefathers young person with greying hair, alopecia just mainly at kidney,If the empty insufficiency of vital energy and blood of liver kidney two, the blood circulation of whole body is just weak, unable nutriment is transported to human bodyUpright highest point " crown ", on head, hair follicle can not get nourishing, and atrophy gradually will cause alopecia, fewHoary hair's experience, sums up this prescription, " kidney storing essence, main reproduction, its Hua Fa ", " hair is the sign of blood condition ",Think that the kidney being the origin of congenital constitution, the product that hair is blood. Kidney storing essence, blood stored in the liver, essence and blood sharing the same origin turns mutuallyChange, both are indispensable.

The fruit of Chinese wolfberry is the liver-kidney tonifying Chinese medicine of commonly using simply, modern medicine study confirm its contain betaine,Polysaccharide, crude fat, crude protein, carrotene, vitamin A, vitamin C, vitamin B1, support one's familyThe nutritional labelings such as element B2 and calcium, phosphorus, iron, zinc, manganese, linoleic acid, have facilitation to hematopoiesis function,Can also anti-ageing, anti-sudden change, antitumor, AFL and the effect such as hypoglycemic. The traditional Chinese medical science is usually come with itTreatment liver-kidney Yin deficiency, soreness and weakness of waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, white hair, de-Send out, the illnesss such as seminal emission, the foster kidney effect of enriching yin is remarkable.

Radix Angelicae Sinensis, its taste is sweet and weigh, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting circulation of blood, bowl spares has,In row, there is benefit, the really gas medicine in blood, the also panacea in blood. Approximately mending to mend of assistant, therefore can support nutritionBlood, tonifying Qi production of sperm, five viscera settling, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute. AssistantLogical to attack, therefore the pain defaecation of dispelling, relieving rigidity of muscles and joints, controls contraction, paralysis, the card such as dry, puckery. Battalion empty andExterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and the Biao Weire that can fall apart greatly, and show not hold back person helps with greatlyYellow and so on, can admittedly show again. Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is notGu person is when keeping away it. All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis energyNourishing blood, is indispensable.

Radix Codonopsis is flat, sweet, the micro-acid of taste. Return spleen, lung channel. Tonifying middle-Jiao and Qi, invigorating the spleen benefit lung. For spleen lungWeakness, the palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst. " book on Chinese herbal medicine justice " carries: Radix CodonopsisPower energy tonifying spleen nourishing the stomach, moistening lung is promoted the production of body fluid, gas in tendon fortune, this is very mutually not far away with ginseng. Its outstanding valuable person,Invigorating the spleen fortune and not dry, grows stomach-Yin and wet, and moistening lung and do not violate is cold and coolly nourished blood and partially do not grown greasyly, inspires clearSun, gas in vibration, and without firm dry fraud. Radix Astragali tonifying Qi, can rise enriching spleen-QI, can admittedly show by beneficial lung again.Radix Codonopsis tonifying Qi, can only invigorating the spleen tonifying Qi, and without the power of solid table, but Radix Codonopsis can also nourishing generate fluid, and the Radix Astragali is without giving birth toThe effect in Tianjin, the double energy of Radix Astragali Li Shui, Radix Codonopsis is without Li Shui effect. This two tastes medicine share can tonifying middle-Jiao and Qi, carriesHigh resistance.

Semen astragali complanati, these product of Latin formal name used at school: AstragaluschinensisLinn.f. are the flat stem Huang of legumeThe dry mature seed of stilbene AstragaluscomplanatusR.Brown.. Warm in nature, taste is sweet. Function cures mainly temperatureFilling liver kidney, controlling nocturnal emission with astringent drugs, contracting urine, improving eyesight. For under lumbago due to the kidney deficiency, seminal emission premature ejaculation, gonorrhoea band, more than urineDrop, dizzy blurred vision. " detailed outline ": kidney tonifying, control pain in the back and let out essence, deficient tired. " it is former that book on Chinese herbal medicine is asked ":Control consumptive lung disease, kidney is cold, and urine is many, loses and drowns, improving eyesight, longue meat. Can protect liver glycogen accumulation, reducing blood lipid,Enzyme falls; Energy reducing heart rate, reduces blood pressure, and increases cerebral blood flow (CBF); Can improve hemorheology index, press downPlatelet aggregation processed; Immunity of organisms be can strengthen, body specificity and non-specific immune function improved;The effect such as have antifatigue, put on weight, resist cold; There are analgesia, calmness, antipyretic, anti-inflammatory, antidiuresis etc.Effect.

Mulberries nourishing yin and nourishing blood medicine; Medicine promotes the production of body fluid; Aperitive. The enriching yin of enriching blood, promotes the production of body fluid and moisturizes. For dizzy earRing, palpitation and insomnia, poliosis, Tianjin wound is thirsty, and interior heat is quenched one's thirst, blood deficiency and constipation. Tonifying liver, kidney-nourishing,Relieve dizziness, high fever, infantile convulsions, epilepsy, etc., grow liquid. Control liver-kidney Yin deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability. BothCan food, can be used as medicine again, the traditional Chinese medical science is thought the sweet acid of mulberries taste, cold nature, enters the heart, liver, kidney channel, is to growThe reinforcement good fruit of intelligence development of strengthening, nourish heart. Have the enriching yin of enriching blood, promote the production of body fluid to quench thirst, the effect such as ease constipation is dry, cures mainly the moonBlood is not enough and having a dizzy spell of causing, tinnitus palpitaition, and irritated insomnia, soreness and weakness of waist and knees, poliosis, quenches one's thirstDry, the diseases such as dry and hard excrement.

Cacumen biotae: Cupressaceae plant cacumen biotae, formal name used at school: Platycladusorientalis (L.) Franco's is tenderBranches and leaves. Medicinal material cacumen biotae Ye Duoyou branch, little and different in size, be flakey. Color is bronzing.The visible leaf in surface is mutually to life, section yellow-white. Quality is crisp, easily fractureed. The micro-perfume (or spice) of gas, bitter and puckery flavorOne in the blood-cooling hemostatic of Chinese medicine hemostatic, the effect that has hemostasis, black beard and hair, cough-relieving to breathe heavily. Cool blood,Hemostasis, wines used as antirheumatic, loose pyogenic infections. Control haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, intestines wind, uterine bleeding, rheumatism numbnessBitterly, bacillary dysentery, hypertension, cough, erysipelas, mumps, scalds. " not Lu ": " main haematemesis,Bleeding from five sense organs or subcutaneous tissue, dysentery blood, metrorrhagia are red white. The beneficial gas of making light of one's life by commiting suicide, makes us cold-resistant heat, the numbness of drying, myogenic. "

Fructus Corni, cures mainly perverse trend fever and chills under the heart, and Wen Zhong, by cold warm numbness, goes three worms, and clothes have been made light of one's life by commiting suicide strong for a long timeCloudy benefit essence, five viscera settling, logical nine orifices, stop the merit of dribbling urination; Take for a long time improving eyesight, brute force all the year round. Fructus Corni,Having another name called cornus officinalis sieb et zucc, medicine jujube, real jujube, fructus corni, meat jujube etc., is the conventional rare traditional Chinese medicine of China, applicationWith a long history. It is gentle with its benefit power, establishing-Yang and do not help fire, enriching yin and oiliness diaphragm, convergence and do not stay heresyDeng special efficacy by successive dynasties use that medical science is liked. Zhang Zhongjing has been formulated " chinkuei shin chewan pills " taking Fructus Corni as monarch.According to chemical analysis, Fructus Corni contains cornin, tartaric acid, gallic acid, the apple that physiologically active is strongerThe active ingredients such as tartaric acid, resin, tannin and multivitamin, have the immunity, anti-inflammatory of enhancing, antibacterial etc.Pharmacological action is medicine simply conventional in tcm clinical practice.

Red sage root hardship, is slightly cold. The thoughts of returning home, Liver Channel. Stasis-dispelling and pain-killing, activating blood to promote menstruation, relieving restlessness clears away heart-fire. For the moonThrough uncomfortable, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest ventral spine pain, and hot numbness pain, sore swells and ache, vexedSleep. For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass caking, sore swells and ache, and falls the pain of injury of falling forward, irregular menstruation,Through closing dysmenorrhoea, postpartum stasis of blood pain etc. Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoeaPain has good effect. . " detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, Siwu Tang is controlled gynecopathy,Pay no attention to antenatal postpartum, how many through water, all can be general, the only taste red sage root is loose, cures mainly identical with it. Gai DanGinseng can break place blood, mend new blood, peaceful tire, the stillborn foetus that falls, stop metrorrhagia stagnant under, menstruation regulating arteries and veins. The red sage root mainly becomesPoint tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, have invigorating blood circulation trace itEffect, and can promote liver blood circulation, be beneficial to liver cell regeneration.

The root of herbaceous peony, the row stasis of blood, pain relieving, cool blood, detumescence. Cure mainly: control the stasis of blood stagnant through closing, hernia lump in the abdomen is gathered, suffer from abdominal pain,Hypochondriac pain, bleeding from five sense organs or subcutaneous tissue, bloody flux, discharging fresh blood stool, hot eyes, carbuncle swell, injury from falling down. The root of herbaceous peony real heat that can purify the blood point,Loose hemostasis is detained. This product function is close with the root bark of tree peony, therefore normal and root bark of tree peony mutual reinforcement between are use. But root bark of tree peony clearing heat and cooling bloodEffect better, the real heat that can purify the blood point, can control again fever due to yin deficiency; And the root of herbaceous peony can only be used for the real heat of blood system,Be good at promoting blood circulation to remove blood stasis. " herbal classic ": main perverse trend stomachache, except blood-arthralgia, broken hard long-pending, fever and chills hernia lump in the abdomen, onlyBitterly, diuresis, beneficial gas.

The pungent micro-hardship of rhizoma cyperi is sweet, and flat function cures mainly: the Xie Yu that regulates the flow of vital energy, menstruction regulating and pain relieving. For stagnation of QI due to depression of the liver, chest,The side of body, abdominal distention, indigestion, irregular menstruation, through closing dysmenorrhoea, cold hernia stomachache, swollen breasts. " guiding principleOrder " carry it: the cold epidemic disease of gas when loose, sharp three warmers, Xie Liuyu, the diet that disappears gathers, and phlegm and retained fluid ruffian is full, and instep is swollen,Abdominal distension, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, lower blood,Hematuria, under married woman's uterine bleeding band, month time is uncomfortable, tire all kinds of diseases and ailments in front postpartum.

The Chinese medicine fleece-flower root have Radix Polygoni Multiflori and RADIX POLYGONI MULTIFLORI PREPARATA point, direct slicing is used as medicine for Radix Polygoni Multiflori, boils with black soya beanJuice is mixed after steaming and is dried and be used as medicine for RADIX POLYGONI MULTIFLORI PREPARATA. The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, the carbuncle that disappears,Relax bowel, be usually used in treating scrofula sore carbuncle, rubella itch, the dry constipation of intestines; The filling liver kidney of RADIX POLYGONI MULTIFLORI PREPARATA function,Benefiting essence-blood, black beard and hair, strengthening the bones and muscles, for sallow, the dizzy tinnitus of the deficiency of blood, poliosis, soreness and weakness of waist and knees,Under extremity numbness, uterine bleeding band, chronic malaria body void etc. RADIX POLYGONI MULTIFLORI PREPARATA of the present invention is the good of invigrating kidneyProduct.

Barrenwort is pungent, sweet, warm, returns liver, kidney channel. Can tonify the kidney and support yang, strengthening the muscles and bones, dispels rheumatism,Be apt to control the insufficiency of the kidney yang, impotence and seminal emission, enuresis frequent micturition; Arthralgia due to wind-dampness, atrophic debility of bones paralysis disease. " book on Chinese herbal medicine is stated " cloud" excessive sheep fire, the main impotence of " herbal classic " medicine is hindered absolutely, and " solar corona " be its treatment of first speech man sun absolutely also, womanCloudy absolutely, calling into the gate of vitality, benefit kidney-Yang person is also. Lid the gate of vitality be the kidney-Yang in kidney, the vigour of the person also,Its so-called yang exhaustion the moon absolutely, the not vigour of basis, how hiss in both withered. So-called beneficial strength, Qiang Zhi, and controlCold air labor gas, the anxious card that waits of muscles and bones contraction, all it helps the event of vigour. Old man's dusk octogenarian, the middle age is forgetful, all YuanyangDecay and can not ascensionist also. Must know that this taste is to reduce to liter, its liter is owing to falling also.

Walnut kernel nature and flavor are sweet, temperature. Return kidney, lung, large intestine channel. Kidney tonifying, warm lung, ease constipation. For waist kneeAching and limp, impotence and seminal emission, the cold of insufficiency type is breathed heavily and is coughed, constipation. Walnut kernel contains a large amount of vitamin Es, often foodWith having moistening lung, the effect of black. In walnut kernel, contain more protein and the unsaturated lipid of needed by humanFat acid, these compositions have extraordinary benefit brain effect, can nourish brain cell, strengthen brain function.

Oriental wormwood clearing heat and promoting diuresis; Removing jaundice. Cure mainly: jaundice, difficult urination, wet sore itch, infectious jaundiceType hepatitis. . pharmaceutical research has cholagogic, and liver function protecting is antipyretic, anti-inflammatory, and reducing blood lipid, expands the effects such as hat,There is significant hepatoprotective effect, to first, hepatitis B, icteric hepatitis, has significant curative effect. There is cholagogic, shortEnter choleresis, the effect that in increase bile, cholic acid and bilirubin are discharged. can increase heart CF,Improve microcirculation, and have hypotensive, reducing blood lipid, anticoagulation, diuresis is antipyretic relievings asthma, and drives away roundworm and inhibitionThe effect of multiple pathogenic dermatophyte and bacterium.

The seed of Chinese dodder has tonifying kidney and benefiting sperm, nourishes the liver to improve visual acuity, consolidates effect of tire stopping leak. Seed of Chinese dodder taste is pungent, sweet,Slightly warm in nature; Return liver,kidney,spleen warp; Gas and property are slow, can float to sink to have tonifying kidney and benefiting sperm, nourish the liver to improve visual acuity,The solid tire of invigorating the spleen. Cure mainly pain in the back tinnitus, impotence and seminal emission, quenches one's thirst, sterile, enuresis incontinence, and under stranguria with turbid discharge band,The head is dim, and food is had loose bowels less, fetal irritability. The seed of Chinese dodder is listed in top grade returning in Shennong's HerbalWarp: smell is pungent, sweet, flat nontoxic. Function with cure mainly: tonifying kidney and benefiting sperm, nourish the liver to improve visual acuity. Be applicable to liverThe waist knee muscles and bones of kidney deficiency is ached, and legs and feet are weak and feeble, impotence and seminal emission, crazy talk, frequent urination, urine haveThe heeltap, dizzy, blurring of vision, Hiccough and deaf and the disease such as women is with down, habitual abortion. For a long timeTaking improving eyesight makes light of one's life by commiting suicide and prolongs life.

Sealwort is used as medicine with rhizome. There is boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions. Be used for the treatment of spleenStomach weakness, fatigue and asthenia, dry food is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, the interior heat disease such as quench one's thirst. ForDiabetes are very effective in cure. Stir-baked RHIZOMA POLYGONATI with yellow rice wine claims again to process sealwort. For clean sealwort steams rear section with the auxiliary material such as wine and black soya beanDry the person of being used as medicine. Have the merit of the channels and collaterals of escaping concurrently. Sealwort has hypotensive, hypoglycemic, reducing blood lipid, anti-stopPulse atherosclerosis, delays senility and effect such as antibacterial grade, and Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect. For cloudyThe empty dryness of the lung, the few phlegm of dry cough, and the labor of the lung-kidney deficiency chronic cough etc. of coughing. For weakness of the spleen and the stomach. Both tonifying spleen-yin,Beneficial temper again, obtain for deficiency of kidney essence dizzy, soreness and weakness of waist and knees, poliosis and quenching one's thirst etc. Sealwort is strengthened muscleBone, beneficial marrow, bleaches and sends out; Be suitable for cough phlegm due to lack of lung-YIN few, dry cough without phlegm, hemoptysisDeng disease.

The dried rhizome of rehmannia: the dried rhizome of rehmannia is also radix rehmanniae recen, Scrophulariaceae herbaceos perennial glutinous rehmannia RehmanniaglutinosaLibosch. fresh or dry piece root. Heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, onlyMenstruation regulating bitterly,, the metal-inflicted wound stasis of blood, cool blood, hemostasis; The effect of fresh rehmannia root and radix rehmanniae recen is different. FreshGlutinous rehmannia clearing heat and promoting fluid, can stop blooding and cool blood, is often for consumption of YIN caused by febrile disease, haematemesis, abscess of throat,The illnesss such as the deep red polydipsia of tongue, a spot dermexanthesis and nosebleed heat. With respect to fresh rehmannia root, radix rehmanniae recen is heat clearing and blood cooling,Also can promote the production of body fluid, all right yin-nourishing, is used for treating yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, the deep red polydipsia of tongue, sends outThe problems such as spot dermexanthesis. The dried rhizome of rehmannia is cold in nature, and function is enriching yin and nourishing kidney. Not only promote the production of body fluid to quench thirst and heat clearing and blood cooling, alsoThere are effect, every blood system to have the people of thermal burn the moon to metrorrhagia, irregular menstruation, fetal irritability, constipation etc., allCan often take. If want to treat warm heat disease, can do qingying decoction with the dried rhizome of rehmannia; If treatment temperatureIn the sick later stage, because waste heat does not also disappear to the greatest extent, the dried rhizome of rehmannia should be used for boiling Qinghao Biejia Tang; In addition, forBlood-head poison is contained, and macula purple is black, and the serious heat of warm heat disease enters the symptom of ying blood, can take that the dried rhizome of rehmannia makes fourRaw ball; The general nourishing Yin and promoting production of body fluid of wanting treats that interior heat quenches one's thirst with constipation, should eat the once liquid soup that the dried rhizome of rehmannia boils.

Fruit of Chinese magnoliavine temperature; Sour, sweet; Return lung, the heart, kidney channel; Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming.Breathe heavily for the void of coughing for a long time, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty,The feeble pulse of losing heart, interior heat is quenched one's thirst, palpitation and insomnia. " Bencao Jingshu " carries: the main beneficial gas person of the fruit of Chinese magnoliavine, lung masterAll gas, acid can be received, and is just entering lung tonifying lung, therefore beneficial gas also. Its main cough with dyspnea person, upper heap soil or fertilizer over and around the roots and not of the deficiency of vital energyGui Yuan, sour flavor having the property of astringing, takes the photograph gas and returns unit, and cough with dyspnea is from removing. Internal lesion caused by overexertion is won thin, tonifying for the deficiency, and reinforcing yin essence,Benefit man essence. " not Lu " supports the five internal organs, heat extraction, and flesh person in raw the moon, the special kidney tonifying of the fruit of Chinese magnoliavine, the tonifying five zang organs of holding concurrently,Kidney storing essence, essence is contained cloudy strong, receive to take the photograph vital qi and return unit, and public region is warm, and digesting food, steams waste matter and changesPrecise and tiny, smart spontaneous, essence is raw cloudy long, therefore main as above all diseases also.

Eclipta prostrata is the conventional liver-nourishing kidney-boosting of the traditional Chinese medical science, cooling blood and hemostasis medicine. To the giddy due to the deficiency of liver-yin and kidney-yinDue to dizzy, tooth mobility, aching pain in waist and back, all diseases of flaccidity and weakness of the lower limbs and blood-head multiple go out blood trouble have goodGood curative effect. Eclipta prostrata contains the chemical compositions such as volatile oil, tannin, saponin, Eclipta prostrata element and vitamin A.Animal experiment has haemostatic effect, and in vitro test has inhibitory action to staphylococcus aureus.

The fruit of glossy privet is secretly not clear for the order of the deficiency of liver-yin and kidney-yin, hypopsia, poliosis, soreness of waist tinnitus and the moonShoot without hitting the target hot etc. This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect. Control order secretly not clear, often joinCultivated land, matrimony vine is equal to use, controls poliosis, often joins the same use of mulberries, and fever due to yin deficiency, often joins the root bark of Chinese wolf-berry.The deficiency of liver-yin and kidney-yin, Light-headedness, seminal emission tinnitus, soreness and weakness of waist and knees, poliosis, coronary heart disease, hyperlipidemia,Hypertension, chronic hepatitis. The protective effect of liver research is thought, the fruit of glossy privet contains oleanolic acid,Give rat skin lower injection, can reduce serum glutamic pyruvic transminase, the hepatic injury of Carbon Tetrachloride Induced is had obviouslyProtective effect, and can promote liver cell regeneration. oleanolic acid also can make in liver triglycerides accumulate minimizing,Degeneration of liver cells necrosis obviously alleviates, glycogen is accumulated increase, serum γglobulin declines; Ultra microstructure canSee in liver cell mitochondrial swelling and the sex change of endoplasmic reticulum vesica alleviates, the inflammatory reaction of hepatic tissue interstitial weakens.

Process for producing granula of the present invention is: get raw material barrenwort 1000g, Radix Codonopsis 1000g, RADIX POLYGONI MULTIFLORI PREPARATA1000g, Radix Angelicae Sinensis 1000g, fruit of glossy privet 1000g, semen astragali complanati 1000g, walnut kernel 1000g, oriental wormwood 1000g,Fruit of Chinese wolfberry 1000g, mulberries 1000g, seed of Chinese dodder 1000g, cacumen biotae 1000g, dried rhizome of rehmannia 1000g, sealwort1000g, Fructus Corni 1000g, red sage root 1000g, root of herbaceous peony 1000g, fruit of Chinese magnoliavine 1000g, Eclipta prostrata 1000g,Rhizoma cyperi 1000g. Get in the water that described bulk drug adds 5-10 doubly to measure and soak 1-2 hour, heating is extracted 2 times,Each 1-2 hour, removes supernatant, merges extract, and 100-120 order filters, then through the molecular weight that dams isThe ultrafiltration post ultrafiltration of 5000-10000,1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 DEG C,Heating is concentrated into paste, is component 1; The dregs of a decoction that water extraction was got are put into 10 times of amount ethanol, heat backStream extracts 2 times, and each extraction time is 1～2 hour, and 100-120 order filters, then through the molecular weight that dams isThe ultrafiltration post ultrafiltration of 5000-10000,1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 DEG C,Heating is concentrated into paste, and stand for standby use, becomes component 2; Above-mentioned two kinds of component pastes are condensed into pasty state, addHoney or dextrin are put into granulator after being in harmonious proportion, and after granulating, with ultraviolet disinfection, then pack.

The preparation method of pill of the present invention is: get raw material barrenwort 1200g, Radix Codonopsis 1300g, RADIX POLYGONI MULTIFLORI PREPARATA1300g, Radix Angelicae Sinensis 1400g, fruit of glossy privet 1200g, semen astragali complanati 1300g, walnut kernel 1400g, oriental wormwood 1200g,Fruit of Chinese wolfberry 1300g, mulberries 1300g, seed of Chinese dodder 1200g, cacumen biotae 1300g, dried rhizome of rehmannia 1300g, sealwort1400g, Fructus Corni 1400g, red sage root 1200g, root of herbaceous peony 1300g, fruit of Chinese magnoliavine 1400g, Eclipta prostrata 1400g,Rhizoma cyperi 1300g, drops into pulverizer and is ground into fine powder, and granularity is 100～120 orders; Sieve, unsiftedCoarse granule adds water 20 liters and soaks 45 minutes, and heating is boiled 35 minutes, filters, and filtrate is for subsequent use; Filter residue adds waterHeating, boils 35 minutes for the second time, filters, and filtrate is for subsequent use; Filter residue adds water again, and heating is for the third time boiled45 minutes, filter; Three filtrates are combined, and heating is concentrated into pasty state, puts into 80 DEG C of oven dry of baking ovenCooling afterwards, and the fine powder sieving; Add honey mediation and be twisted into pill.

The preparation method of oral solutions of the present invention: by all raw material barrenwort 1300g, Radix Codonopsis 1300g, systemTuber of multiflower knotweed 1300g, Radix Angelicae Sinensis 1400g, fruit of glossy privet 1200g, semen astragali complanati 1200g, walnut kernel 1300g, oriental wormwood1200g, fruit of Chinese wolfberry 1300g, mulberries 1300g, seed of Chinese dodder 1200g, cacumen biotae 1400g, dried rhizome of rehmannia 1300g,Sealwort 1400g, Fructus Corni 1300g, red sage root 1200g, root of herbaceous peony 1300g, fruit of Chinese magnoliavine 1400g, Eclipta prostrata1400g, rhizoma cyperi 1300g. Put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour,No. 2 extracts are merged and left standstill; The dregs of a decoction of the component raw medicinal material of more above-mentioned alcohol extract being crossed add 10 timesWater gaging heating and refluxing extraction 2 times, each 1～2 hour, merges No. 2 extracts to leave standstill; By above-mentioned two kindsExtract merges concentrated, and above-mentioned steps reclaims after ethanol decompression and puts into inspissator when concentrated, is concentrated into 90DEG C time the relative density concentrate that is 1.05, set to 0～5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added to 0.3The filter aid diatomite of %, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml and contains1g crude drug amount. Add dextrin and be in harmonious proportion, bottling.

The present invention's focus of going directly, targeting is strong, and the scattered silt of invigorating blood circulation, has no side effect, and medicine can be oozed rapidlyEnter to make absorption of human body, and instant effect, result for the treatment of is good, with low cost, reparation technology is simple and easy to do.

Pharmacology toxicity test

1. irritation test

Get rabbit and shave hair, induce and excite contact test with pill of the present invention, at 24 hours and 48Viewing test rabbit after hour, all loseing skin has the phenomenon such as erythema and oedema, with negative control group indifferenceDifferent. Result shows, this patch is bordering on zero to dermoreaction intensity, without skin allergic reaction.

2. endo-medicine cumulative toxicity test report

Test method: select 20 healthy mices, female, male each 10, it is one that dosage designs every 5 daysPhase, each issue dosage be respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, the LD50 female, male mice of this sample is 5000m part/k part BW (five agentAmount is 500,750,1100,1700,2500m part/k part BW). Within every 5 days, weigh once, adjustment is givenDose, by 0.1ml/10 part BW per os gavage. After 20 days, animal occurs without death condition, test knotBundle, by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.

3. acute toxicity test

Give white mouse oral administration medicine supplying with 300 times of the clinical consumption per day of this product endo-medicine, observe 5. Result instituteHave that animal is strong deposits, its activity, diet, hair, excreta are no abnormal, have no toxic reaction. RightWhite mouse damaged skin carries out irritation test, there are no irritative response and other bad reaction.

Toxicity test proves, the not toxic effect of said preparation and bad reaction, and clinical practice is safe and reliable.

Clinical testing:

Young person with greying hair is common clinical. We choose the disease of outpatient service between 4 years year June of in June, 2008-2012Example, treats this sick 100 examples with growing and blacking hair Chinese medicine preparation, and curative effect is comparatively satisfied. Now be reported as follows.

1, data and method

1.1 physical data

100 examples all meet document dependent diagnostic standard, get rid of leucoderma, albinism, pseudopelade, blackPoint tinea, epilation tinea, leprosy alopecia, folliculitis decalvans, favus are bald etc., are divided at random two groups. TreatmentOrganize 50 examples, the male sex's 29 examples, women's 21 examples; Age 13-25 year, average 18.45 years old; The course of disease 3 monthsTo 6 years, average 3.1 years. Control group 50 examples, the male sex's 31 examples, women's 19 examples; Age 12-25 year, average19.21 years old; The course of disease 3 months to 5 years, average 2.6 years. Two groups of above-mentioned data no significant difference (p >0.05), there is comparativity.

1.2 methods for the treatment of

The oral growing and blacking hair preparation for the treatment of group, system in institute of the court, Fang Yong: barrenwort 11g, Radix Codonopsis 12g,RADIX POLYGONI MULTIFLORI PREPARATA 13g, Radix Angelicae Sinensis 11g, fruit of glossy privet 12g, semen astragali complanati 11g, walnut kernel 11g, oriental wormwood 12g, matrimony vineSub-12g, mulberries 12g, seed of Chinese dodder 13g, cacumen biotae 13g, dried rhizome of rehmannia 13g, sealwort 12g, Fructus Corni 12g,Red sage root 12g, root of herbaceous peony 12g, fruit of Chinese magnoliavine 13g, Eclipta prostrata 12g, rhizoma cyperi 12g. Make each 2 balls of pill,Every day 3 times. The oral cystine 100mg of control group, oryzanol 10mg, every day 3 times. All treat 90D for two groups,All stop external therapy in other therebetween.

Hair growth situation before and after 1.3 observation item records contrast therapy, detects blood normal before and after treatmentRule and IgG, IgA, IgM, and relatively its variation.

1.4 criterion of therapeutical effect reference literature relevant portions are worked out. Recovery from illness: blackening hair, newborn hair is blackLook, reaches beauty treatment requirement, hair pulling test feminine gender. Effective: newborn hair fine hair on birds or animals hair growth, blackening hair is brightAobvious, hair pulling test feminine gender. Effective: blackening hair is comparatively obvious, there is brown doping wherein, the growth of fine hair on birds or animals hairHalf is black, and hair pulling test is negative or positive. Invalid: only there is minority blackening hair, with streaks of white hair, epilation examinationTest the positive.

1.5 statistical procedures data represent with-X ± S, adopt x²Inspection and t inspection.

2 results

2.1 liang of group curative effects are relatively in table 1. Result shows that treatment group curative effect is better than control group (p < 0.01).

Table 1 liang relatively n (%) of group curative effect

Group

n

Recovery from illness

Effective

Effectively

Invalid

Effectively total

Treatment group

50

36（72）

8（16）

4（8）

2（4）

96*

Control group

50

21（42）

6（12）

3（6）

20（40）

60

With control group comparison, * p < 0.01

2.2 treatment group red blood cell count(RBC)s and hemoglobin index change in table 2.

After treatment group treatment, red blood cell count(RBC), hemoglobin are treated front obvious raising (p < 0.01).

Red blood cell count(RBC), hemoglobin level comparison (X ± S) after the treatment of table 2 treatment group

Relatively front with treatment, * p < 0.01.

2.3 treatment group serum IgGs, IgA, IgM index change in table 3. Treatment group treatment rear IgG, IgA,IgM all obviously improves p < 0.01 before treating.

IgG, IgA, IgM level comparison (G/L ,-X ± S) before and after the treatment of table 3 treatment group

Time	n	IgG	IgA	IgM
					Before treatment	50	5.13±0.13	0.78±0.18	0.87±0.17
After treatment	50	8.13±0.19*	2.01±0.27*	1.45±0.23*

Relatively front with treatment, * p < 0.01.

3 discuss

Blood-head, kidney qi deficiency are weak, qi and blood is weak is all the reason that causes white hair. The source of nutrition of hairIn blood, if hair bleaches or comes off, be because of deficiency of liver-blood, a little less than kidney qi deficiency mostly. Therefore,The methods for the treatment of of the traditional Chinese medical science is tonifying liver blood, kidney tonifying gas. Chinese traditional treatment white hair according to theory of traditional Chinese medical science is: " liverMain store blood, hair is the sign of blood condition ", " kidney controlling essence storage, its Hua Fa ", " heart governing blood and vessels ", " lung governing skin and hair "." spleen is source of generating QI and blood ". That is to say that the growth of hair and color and luster change, with the vital organs of the human bodyFunction prosperity and decline, yang-energy essence and blood warm moisten support closely bound up. The traditional Chinese medical science is thought generation and the liver kidney essense of this diseaseBlood deficiency, hair lose foster relevant. Therefore prepared fleece flower root, mulberry fruit enriching blood and replenishing vital essence in growing and blacking hair oral liquid;Radix Astragali reinvigoration, air making-up and spleen enlivening; Juglandis,semen kidney tonifying benefit blood, embellishes but not dry; The red sage root, dried rhizome of rehmannia heat-clearingCool blood, nourshing blood and promoting blood circulation is in order to hair growth; The sweet slow coordinating the drug actions of a prescription of sealwort. Full side's compatibility, plays benefit altogetherThe merit of liver and kidney benefiting, reinvigoration, benefiting qi and nourishing blood, growing and blacking hair. Show by observation, it is carriedThe effect of high red blood cell, hemoglobin, thus from Point of View of Clinical confirmed traditional Chinese medicine " send out for blood itRemaining " theoretical and by the trichogenous validity of enriching blood.

Specific embodiment 1: Chen, man, 16 years old, main suit when medical in 2009: hair is from graduating from primary schoolStart slowly to bleach, now almost complete white. Often feel tired out, eye dry eyes are puckery, and poor appetite is weak.Failure of memory is obvious. Tried Chinese medicine, western medicine, effect is all not obvious, the obvious depauperation of child,More thin and weak once external application or take medicine orally treatment by Chinese herbs, symptom slightly alleviates, and increases the weight of but meet when anxious state of mind. ExamineArteries and veins is because deficiency of liver-blood, a little less than kidney qi deficiency, uses following medicine treatment:

Fang Yong: barrenwort 13g, Radix Codonopsis 12g, RADIX POLYGONI MULTIFLORI PREPARATA 13g, Radix Angelicae Sinensis 12g, fruit of glossy privet 12g, Sha YuanSub-11g, walnut kernel 11g, oriental wormwood 12g, fruit of Chinese wolfberry 12g, mulberries 12g, seed of Chinese dodder 13g, cacumen biotae 13g,Dried rhizome of rehmannia 13g, sealwort 12g, Fructus Corni 12g, red sage root 12g, root of herbaceous peony 12g, fruit of Chinese magnoliavine 13g, Eclipta prostrata 12g,Rhizoma cyperi 12g. Enjoin and on diet, should note the food of taking in iron content and copper more. Animal Liver, eggs, blackAuricularia auriculajudae, sea-tangle, soybean, sesame paste etc., hard fruit, apricot spread dry and dry bean etc. Replenishing vitaminsB1、B2、B6。

Treat January, sensation spirit is much better. Memory improves obviously. No longer often tired; Eye dry eyesPuckery phenomenon is improved. Hair starts obvious blackening, and black and white doping, has become hoary, continues to use 3Month, the whole blackening of newborn hair, transference cure, starts to become normal type, follows up a case by regular visits to 3 years without recurrence,Through curing.

Specific embodiment 2: go into business certain, female, 20 years old, readme was subject to father's heredity, occurred since the childhood white hair, andAnd along with the growth at age, white hair is more and more. Go various big hospital treatment, hormone, treatment by Chinese herbs effectAll not obvious, hair is now grizzled, and sensation is own to old lady. Need often hair dyeing, injury scalp,And there is cancered danger. Mood is dispirited, weak, and irascibility is vigorous, tearing against wind. Like anger,Memory is bad, occurs on the face color spot. Feel the pulse because deficiency of liver-blood, a little less than kidney qi deficiency, uses following medicineTreatment.

Fang Yong: barrenwort 12g, Radix Codonopsis 13g, RADIX POLYGONI MULTIFLORI PREPARATA 11g, Radix Angelicae Sinensis 12g, fruit of glossy privet 12g, Sha YuanSub-11g, walnut kernel 11g, oriental wormwood 12g, fruit of Chinese wolfberry 12g, mulberries 12g, seed of Chinese dodder 13g, cacumen biotae 13g,Dried rhizome of rehmannia 13g, sealwort 12g, Fructus Corni 12g, red sage root 12g, root of herbaceous peony 12g, fruit of Chinese magnoliavine 12g, Eclipta prostrata 12g,Rhizoma cyperi 12g. Enjoin and on diet, should note the food of taking in iron content and copper more. Animal Liver, eggs, blackAuricularia auriculajudae, sea-tangle, soybean, sesame paste etc., hard fruit, apricot spread dry and dry bean etc. Replenishing vitaminsB1、B2、B6。

Treat January, spirit improves. Complexion starts to take a turn for the better, and color spot disappears. Memory improves obviously. No longerOften tired; The puckery phenomenon of eye dry eyes is improved. Hair starts obvious blackening, and black and white doping, has become grey headSend out, continue to use 3 months, the whole blackening of newborn hair, transference cure, follows up a case by regular visits to 2 years without recurrence,Cure. It is beautiful to become now the youth; Optimistic confidence.

Claims (10)

1. a Chinese medicine preparation for the treatment of young person with greying hair, is characterized in that, described preparation is by following weight portionThe bulk drug of number is made: 10～20 parts of barrenwort, 10～20 parts of Radix Codonopsis, 10～20 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, Radix Angelicae Sinensis10～20 parts, 10～20 parts of the fruit of glossy privets, 10～20 parts of semen astragali complanatis, 10～20 parts of walnut kernel, oriental wormwood 10～20 parts, 10～20 parts of the fruits of Chinese wolfberry, 10～20 parts of mulberries, 10～20 parts of the seed of Chinese dodders, 10～20 parts of cacumen biotaes,10～20 parts, the dried rhizome of rehmannia, 10～20 parts of sealworts, 10～20 parts of Fructus Cornis, 10～20 parts of the reds sage root, the root of herbaceous peony 10～20 parts, 10～20 parts, the fruit of Chinese magnoliavine, 10～20 parts of Eclipta prostratas, 10～20 parts of rhizoma cyperis.

2. the Chinese medicine preparation for the treatment of according to claim 1 young person with greying hair, is characterized in that, described preparationBulk drug by following parts by weight is made: 10～15 parts of barrenwort, and 10～15 parts of Radix Codonopsis, RADIX POLYGONI MULTIFLORI PREPARATA 10～15 parts, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of the fruit of glossy privets, 10～15 parts of semen astragali complanatis, 10～15 parts of walnut kernel,10～15 parts of oriental wormwoods, 10～15 parts of the fruits of Chinese wolfberry, 10～15 parts of mulberries, 10～20 parts of the seed of Chinese dodders, cacumen biotae10～20 parts, 10～20 parts, the dried rhizome of rehmannia, 10～20 parts of sealworts, 10～20 parts of Fructus Cornis, 10～20 parts of the reds sage root,10～20 parts of the root of herbaceous peonys, 10～20 parts, the fruit of Chinese magnoliavine, 10～20 parts of Eclipta prostratas, 10～20 parts of rhizoma cyperis.

3. the Chinese medicine preparation for the treatment of according to claim 1 young person with greying hair, is characterized in that, described preparationBulk drug by following parts by weight is made: 10～20 parts of barrenwort, and 10～20 parts of Radix Codonopsis, RADIX POLYGONI MULTIFLORI PREPARATA 10～20 parts, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of the fruit of glossy privets, 10～20 parts of semen astragali complanatis, 10～20 parts of walnut kernel,10～20 parts of oriental wormwoods, 10～20 parts of the fruits of Chinese wolfberry, 10～20 parts of mulberries, 10～15 parts of the seed of Chinese dodders, cacumen biotae10～15 parts, 10～15 parts, the dried rhizome of rehmannia, 10～15 parts of sealworts, 10～15 parts of Fructus Cornis, 10～15 parts of the reds sage root,10～15 parts of the root of herbaceous peonys, 10～15 parts, the fruit of Chinese magnoliavine, 10～15 parts of Eclipta prostratas, 10～15 parts of rhizoma cyperis.

4. as described in any one in claim 1～3, treat the preparation side of young person with greying hair's Chinese medicine preparation for one kindMethod, is characterized in that, the process for producing granula of described Chinese medicine preparation comprises the following steps:

A, get raw material and put into water and soak, heat is extracted 2 times, becomes paste, is component 1;

B, the dregs of a decoction add alcohol extract 2 times, and thickening filtration is paste, are component 2;

C, above-mentioned two kinds of pastes are condensed into pasty state add dextrin or honey to granulate, sterilizing.

5. preparation method according to claim 4, is characterized in that, in described step a, described in gettingIn the water that bulk drug adds 5-10 doubly to measure, soak 1-2 hour, heating is extracted 2 times, and each 1-2 hour, goesClear liquid, merges extract, and 100-120 order filters, then is the ultrafiltration post of 5000-10000 through the molecular weight that damsUltrafiltration, 1.36 medicinal extract when ultrafiltrate reduced pressure concentration relative density is 80 DEG C, heating is concentrated into paste, quietThe use of purchasing, becomes component 1.

6. preparation method according to claim 4, is characterized in that, in described step b, by ethanolThe dregs of a decoction that extracted are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, and each extraction time is 1～2Hour, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate1.36 medicinal extract when reduced pressure concentration relative density is 80 DEG C, heating is concentrated into paste, and stand for standby use, becomesComponent 2.

7. preparation method according to claim 6, is characterized in that, in described step c, by above-mentionedTwo kinds of component pastes are condensed into pasty state, add after honey or dextrin are in harmonious proportion and put into granulator, use purple after granulatingOutside line sterilizing, then pack.

8. state a preparation method for treatment young person with greying hair's Chinese medicine preparation as any one in claim 1～3,It is characterized in that, the preparation process that described Chinese medicine preparation is pill is: first described bulk drug is dropped into many meritsCan extract twice by extractor, add for the first time 8-10 times of water gaging and decoct 1-2 hour, add for the second time 4-8 times of water gagingDecoct 1-2 hour, merge twice decocting liquid, filter to get filtrate; Decompression is put into inspissator and is concentrated into pasty state, putsEnter after 80 DEG C of oven dry of baking oven coolingly, grind to form fine powder, call in honey and make honey refining pill, bottling.

9. preparation method according to claim 8, is characterized in that, above-mentioned steps decompression is put into concentratedWhen concentrated in device, the concentrate that while being concentrated into 90 DEG C, relative density is 1.05, sets to 0～5 DEG C of deepfreezes 24Hour; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted economic benefits and social benefits vacuum concentrator againIn, be concentrated into every 1ml containing 1g crude drug amount.

10. according to the Chinese medicine preparation for the treatment of young person with greying hair described in any one in claim 1～3, its feature existsIn, the formulation of described treatment young person with greying hair's Chinese medicine preparation is: sugar coated tablet, film coated tablet, enteric coatingTablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder,Sublimed preparation, injection, suppository, emplastrum or creme.