CN105662916B - Composition for repairing sebum membrane - Google Patents
Composition for repairing sebum membrane Download PDFInfo
- Publication number
- CN105662916B CN105662916B CN201610214919.XA CN201610214919A CN105662916B CN 105662916 B CN105662916 B CN 105662916B CN 201610214919 A CN201610214919 A CN 201610214919A CN 105662916 B CN105662916 B CN 105662916B
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- CN
- China
- Prior art keywords
- sodium
- trehalose
- groups
- skin
- sodium hyaluronate
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- 239000000203 mixture Substances 0.000 title claims abstract description 57
- 210000002374 sebum Anatomy 0.000 title claims description 25
- 239000012528 membrane Substances 0.000 title abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 68
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 65
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 65
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 64
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 52
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 52
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 49
- 239000011780 sodium chloride Substances 0.000 claims abstract description 34
- 239000002562 thickening agent Substances 0.000 claims abstract description 26
- 239000004519 grease Substances 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 38
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 34
- 235000002639 sodium chloride Nutrition 0.000 claims description 33
- 229960002668 sodium chloride Drugs 0.000 claims description 33
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 26
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 26
- 235000013399 edible fruits Nutrition 0.000 claims description 18
- 235000011187 glycerol Nutrition 0.000 claims description 17
- 235000019197 fats Nutrition 0.000 claims description 15
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 15
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical group [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 238000012423 maintenance Methods 0.000 claims description 13
- 229940057910 shea butter Drugs 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 229920002125 Sokalan® Polymers 0.000 claims description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
- 229960001631 carbomer Drugs 0.000 claims description 8
- 229920002521 macromolecule Polymers 0.000 claims description 7
- 239000004006 olive oil Substances 0.000 claims description 6
- 235000008390 olive oil Nutrition 0.000 claims description 6
- AXPZIVKEZRHGAS-UHFFFAOYSA-N 3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one Chemical compound [O-][N+](=O)C1=CC=CC=C1OCC1OC(=O)C(CC=2C=CC=CC=2)C1 AXPZIVKEZRHGAS-UHFFFAOYSA-N 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000014121 butter Nutrition 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 40
- 230000000694 effects Effects 0.000 abstract description 13
- 208000024891 symptom Diseases 0.000 abstract description 10
- 230000003796 beauty Effects 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 9
- 238000002474 experimental method Methods 0.000 abstract description 7
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 239000007864 aqueous solution Substances 0.000 abstract description 4
- 235000002906 tartaric acid Nutrition 0.000 abstract description 4
- 239000011975 tartaric acid Substances 0.000 abstract description 4
- 208000003251 Pruritus Diseases 0.000 abstract description 3
- 230000008859 change Effects 0.000 abstract description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 2
- 206010070834 Sensitisation Diseases 0.000 abstract description 2
- 239000003995 emulsifying agent Substances 0.000 abstract description 2
- 230000001804 emulsifying effect Effects 0.000 abstract description 2
- 239000008103 glucose Substances 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 230000008313 sensitization Effects 0.000 abstract description 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 238000005562 fading Methods 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 32
- 229920002674 hyaluronan Polymers 0.000 description 27
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 26
- 229960003160 hyaluronic acid Drugs 0.000 description 26
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 13
- 230000001815 facial effect Effects 0.000 description 9
- 239000000499 gel Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 8
- 238000005067 remediation Methods 0.000 description 7
- 150000003625 trehaloses Chemical class 0.000 description 7
- 230000002411 adverse Effects 0.000 description 6
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000012545 processing Methods 0.000 description 5
- 201000004624 Dermatitis Diseases 0.000 description 4
- 210000000481 breast Anatomy 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 238000007493 shaping process Methods 0.000 description 4
- 230000000392 somatic effect Effects 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010042682 Swelling face Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 201000010251 cutis laxa Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 229910052979 sodium sulfide Inorganic materials 0.000 description 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 125000000647 trehalose group Chemical group 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a skin lipid membrane repairing composition which is prepared from the following raw materials in percentage by mass: 0.1-1% of sodium hyaluronate, 0.2-4% of trehalose, 2-15% of humectant, 1-10% of grease, 0.1-1% of thickening agent and 80-83.9% of solution, wherein the solution is glucose aqueous solution with mass concentration of 1-3% or sodium chloride aqueous solution with mass concentration of 0.3-1.2%. Experiments prove that the composition for repairing the skin lipid membrane can effectively relieve the symptoms of red swelling, hot pain, skin fading, pruritus and the like caused by the skin after the beauty means such as laser beauty, tartaric acid skin change and the like are treated, the absorption effect is good, the gel prepared by the composition does not contain an emulsifier, belongs to a non-emulsifying system, the sensitization risk is reduced, the preparation method is simple, the production period is short, the prescription is simplified, and the cost is low.
Description
Technical field
The invention belongs to biomedicine technical field, is specifically related to a kind of composition of sebum film reparation and containing this
The preparation of composition.
Background technology
Two during the last ten years, and with deepening continuously for China's reform and opening-up, medical shaping and beauty industry is a dark horse, and development is fast
Speed, market is vigorous not to wane.21 century beauty is already required into the life of young women.2014, beauty mechanism of China
The overall market capacity has reached 553,000,000,000 yuan, wherein medical shaping and beauty market accounts for 3.8% share, i.e. medical shaping in 2014
Beauty industry whole nation total quantity consumed breaks through 21,000,000,000 yuan.Recent years, Chinese people are more and more stronger to beautiful and fashion pursuit
Strong, China's beauty industry will also persistently keep rapid growth situation.
The cardinal principle of laser beautifying employ it is beneficial to human body, through ability compared with it is strong, tissue absorptivity is high
Light-wave band, the stimulation using weak laser to biological tissue, facial meridian point is effectively stimulated, accelerates blood circulation,
Improve the supply condition of skin, increase skin tissue's nutrition, promote the anabolism and tissue repair of human body, so as to improve face
The colour of skin is dark and gloomy, pigmentation, cutis laxa, wrinkle, pouch are sagging, livid ring around eye, the thick, pachylosis of pore etc., makes facial skin
The ruddy gloss of skin, elasticity strengthen, the aging of delaying skin, play the effect of skin maintenance.But the problem of following, also exist
These women compatriot to like to be beautiful are annoying, cause skin barrier to be damaged after laser beautifying, and then the symptoms such as red, swollen, hot, pain occur
Annoying these women compatriot.
The patent No. 200510042021.0《For the trehalose of cosmetics and hyaluronic acid compositions and preparation method thereof》
A kind of composition of the trehalose available for cosmetics and hyaluronic acid is disclosed, and only illustrates that said composition has replenishing water and preserving moisture
Effect, the optimal use ratio of said composition, the Sodium Hyaluronate effect of which kind of molecular weight is more preferable and said composition its
He acts on undisclosed.
The content of the invention
The purpose of the present invention is overcome the deficiencies in the prior art, there is provided a kind of sebum film remediation composition.
Second object of the present invention is to provide a kind of gel of the composition containing sebum film reparation.
Technical scheme is summarized as follows：
A kind of sebum film maintenance composition, is made up of following raw materials by mass percentage：Sodium Hyaluronate 0.1%-1%,
Trehalose 0.2%-4%, NMF 2%-15%, grease 1%-10%, thickener 0.1%-1% and solution 80%-83.9%,
The aqueous sodium chloride that the solution is the D/W that mass concentration is 1%-3% or mass concentration is 0.3%-1.2%
Liquid.
The Sodium Hyaluronate is 1 by mass ratio:(2~5):The molecular weight ranges of (5~30) 1000000~
2000000 macromolecule Sodium Hyaluronate, the middle numerator sodium hyaluronate and molecule of molecular weight ranges 100000~400000
The micromolecule hyaluronic acid sodium that scope is measured 5000~10000 forms.
NMF is the one or more in glycerine, propane diols, 1,3-BDO.
Grease is at least one of shea butter, Butyrospermum parkii fruit fat and olive oil.
Thickener is at least one of Sodium Polyacrylate and carbomer.
Gel containing above-mentioned sebum film maintenance composition, is made of following methods：
(1) Sodium Hyaluronate, thickener are well mixed with NMF；
(2) trehalose is mixed with solution, dissolves trehalose, obtain aqueous trehalose；
(3) mixture for preparing step (1) is added in aqueous trehalose, is heated to 80-90 DEG C, adds grease, stirring
10-30 minutes；
(4) 30-40 DEG C is cooled to, is produced.
It is demonstrated experimentally that the present invention sebum film reparation composition, can effectively remissive treatment via laser beautifying, tartaric acid
Change the redness after the beauty means such as skin caused by skin, heat pain, take off the symptoms such as skin, itch, assimilation effect is good, is prepared with composition
Gel is free of emulsifying agent, belongs to non-emulsified system, reduces the risk of sensitization, and preparation method is simple, with short production cycle, place
Fang Jingjian, cost are low.
Embodiment
With reference to specific embodiment, the present invention is further illustrated.
Embodiment 1
A kind of sebum film maintenance composition, is made up of following raw materials by mass percentage：Sodium Hyaluronate 0.1%, marine alga
Sugar 0.2%, (glycerine and propane diols mass ratio are 1 to NMF:2) 15%, shea butter 1%, Sodium Polyacrylate 1% and glucose
The aqueous solution 82.7% (mass concentration of D/W is 1%).
The hyaluronic acid of the present embodiment is 1 by mass ratio:5:30 molecular weight ranges molecular weight ranges 1000000~
1200000 macromolecule hyaluronic acid, middle molecular weight hyaluronic acid and the molecular weight model of molecular weight ranges 300000~400000
It is trapped among 5000~7000 micromolecule hyaluronic acid composition.
Embodiment 2
A kind of sebum film maintenance composition, is made up of following raw materials by mass percentage：Sodium Hyaluronate 1%, trehalose
4%, (glycerine, propane diols and butanediol mass ratio are 2 to NMF:1:3) 2%, Butyrospermum parkii fruit fat 10%, carbomer 0.1%
With D/W 82.9% (mass concentration of D/W is 3%).
The hyaluronic acid of the present embodiment is 1 by mass ratio:3:16 molecular weight ranges 1800000~2000000 it is big
Molecular weight hyaluronic acid, the middle molecular weight hyaluronic acid and molecular weight ranges of molecular weight ranges 100000~200000 8000~
10000 micromolecule hyaluronic acid composition.
Embodiment 3
A kind of sebum film maintenance composition, is made up of following raw materials by mass percentage：Sodium Hyaluronate 0.3%, marine alga
Sugar 2%, (glycerine and butanediol mass ratio are 2 to NMF:3) 10%, the grease (mass ratio of Butyrospermum parkii fruit fat and shea butter
For 1:1) 3%, Sodium Polyacrylate 0.8% and sodium-chloride water solution 83.9%, (mass concentration of sodium-chloride water solution is
0.9%).
The hyaluronic acid of the present embodiment is 1 by mass ratio:2:5 molecular weight ranges are at big point of 1400000~1600000
Son amount hyaluronic acid, the middle molecular weight hyaluronic acid and molecular weight ranges of molecular weight ranges 200000~300000 are 7000~8000
Micromolecule hyaluronic acid composition.
Embodiment 4
A kind of sebum film maintenance composition, is made up of following raw materials by mass percentage：Sodium Hyaluronate 0.7%, marine alga
Sugar 1.8%, glycerine 12%, olive oil 5%, (Sodium Polyacrylate and carbomer mass ratio are 1 to thickener：1) 0.5% and sodium chloride
The aqueous solution 80%, (mass concentration of sodium-chloride water solution is 0.3%).
The hyaluronic acid of the present embodiment is 1 by mass ratio:4:23 molecular weight ranges 1700000~1800000 it is big
Molecular weight hyaluronic acid, the middle molecular weight hyaluronic acid and molecular weight ranges of molecular weight ranges 200000~400000 6000~
8000 micromolecule hyaluronic acid composition.
Embodiment 5
A kind of sebum film maintenance composition, is made up of following raw materials by mass percentage：Sodium Hyaluronate 0.3%, marine alga
Sugar 1.2%, (propane diols and butanediol mass ratio are 1 to NMF:3) 8%, (mass ratio of olive oil and shea butter is grease
1：1) 7%, carbomer 0.4% and sodium-chloride water solution 83.1% (mass concentration of sodium-chloride water solution is 1.2%)
The hyaluronic acid of the present embodiment is 1 by mass ratio:3:20 molecular weight ranges 1200000~1400000 it is big
Molecular weight hyaluronic acid, the middle molecular weight hyaluronic acid and molecular weight ranges of molecular weight ranges 100000~200000 5000~
6000 micromolecule hyaluronic acid composition.
Embodiment 6
Gel containing sebum film remediation composition, it is made of following methods：
(1) each raw material is taken by embodiment 1；
(2) it is Sodium Hyaluronate, Sodium Polyacrylate, glycerine and mixed with propylene glycol is uniform；
(3) trehalose is mixed with D/W, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 80 DEG C, adds shea butter, stirring
30 minutes；
(5) 40 DEG C are cooled to, is produced.
Embodiment 7
Gel containing sebum film remediation composition, it is made of following methods：
(1) each raw material is taken by embodiment 2；
(2) Sodium Hyaluronate, carbomer, glycerine, propane diols and butanediol are well mixed；
(3) trehalose is mixed with D/W, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 90 DEG C, adds Butyrospermum parkii fruit fat,
Stirring 10 minutes；
(5) 40 DEG C are cooled to, is produced.
Embodiment 8
Gel containing sebum film remediation composition, it is made of following methods：
(1) each raw material is taken by embodiment 3；
(2) Sodium Hyaluronate, Sodium Polyacrylate, glycerine and butanediol are well mixed；
(3) trehalose is mixed with sodium-chloride water solution, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 85 DEG C, adds grease Butyrospermum parkii
Fruit fat and shea butter, stir 20 minutes；
(5) 40 DEG C are cooled to, is produced.
Embodiment 9
Gel containing sebum film remediation composition, it is made of following methods：
(1) each raw material is taken by embodiment 4；
(2) Sodium Hyaluronate, Sodium Polyacrylate, carbomer are well mixed with glycerine；
(3) trehalose is mixed with sodium-chloride water solution, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 83 DEG C, adds olive oil, stirring 30
Minute；
(5) 35 DEG C are cooled to, is produced.
Embodiment 10
Gel containing sebum film remediation composition, it is made of following methods：
(1) each raw material is taken by embodiment 5；
(2) Sodium Hyaluronate, carbomer, propane diols and butanediol are well mixed；
(3) trehalose is mixed with sodium-chloride water solution, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 87 DEG C, adds olive oil and breast wood
Fruit oil, is stirred 15 minutes；
(5) 30 DEG C are cooled to, is produced.
Experiment：
Comparison liquid used in following experiments and preparation method thereof is as follows：
Compare 1 group：By taking embodiment 1 in Chinese patent ZL200510042021.0 as an example, by trehalose 1.5g, hyaluronic acid
Sodium 0.2g (inventor has found through retrieval, 2005 and in the past, between the molecular weight of Sodium Hyaluronate is 500000 to 2000000,
Compare the Sodium Hyaluronate that this molecular weight section is chosen in 1 group of preparation), tween 0.2g, ethyl hydroxy benzoate 0.03g be dissolved in 98g water,
Obtain solution.
Compare 2 groups：With the patent No. 201310010661.8《Functional preparation and system for atopic dermatitis auxiliary treatment
Preparation Method》Exemplified by middle embodiment 1：0.2 part of Sodium Hyaluronate, 5 parts of emulsifing thickener, 5 parts of grease, add deionized water to 100 parts.
Preparation method：Emulsifing thickener (component A) is added in kettle, and is heated to 75 DEG C；Grease (B component) is added
In hot pot, and it is heated to 75 DEG C；A groups solution is mixed in pot is emulsified with B groups solution, and emulsifying 10min；By above-mentioned breast
Liquid is cooled to 40 DEG C, adds primary raw material Sodium Hyaluronate, stirs discharging, standing after 20min.
Compare 3 groups：
(1) take：0.3g hyaluronic acids (are 1 by mass ratio:2:5 molecular weight ranges 1400000~1600000 it is big
Molecular weight hyaluronic acid, the middle molecular weight hyaluronic acid and molecular weight ranges of molecular weight ranges 200000~300000 7000~
8000 micromolecule hyaluronic acid composition), 10g NMF (glycerine：Butanediol=2:3), grease 3g (Butyrospermum parkii fruit fat and breast
Wooden fruit oil quality ratio is 1：1), 0.8g thickeners (Sodium Polyacrylate) and sodium-chloride water solution 85.9g (sodium-chloride water solution
0.9%) mass concentration is.
(2) Sodium Hyaluronate, thickener are well mixed with NMF；
(3)) mixture for preparing step (2) is added in sodium-chloride water solution, is heated to 85 DEG C, adds grease, stirring
20 minutes；
(5) 40 DEG C are cooled to, is produced.
Compare 4 groups：
(1) 2g trehaloses, 10g NMF (glycerine are claimed：Butanediol mass ratio is 2:3), 3g greases (Butyrospermum parkii fruit fat with
The mass ratio of shea butter is 1：1), 0.8g thickeners (Sodium Polyacrylate) and sodium-chloride water solution 84.2g.
(2) thickener is well mixed with NMF；
(3) trehalose is mixed with sodium-chloride water solution, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 85 DEG C, adds grease, stirs 20 points
Clock；
(5) 40 DEG C are cooled to, is produced.
Compare 5 groups：
(1) 0.3g molecular weight is referred to as 1400000~1600000 Sodium Hyaluronate, 2g trehaloses, and 10g NMFs are (sweet
Oil：Butanediol=2:3), (Butyrospermum parkii fruit fat and shea butter ratio are 1 to 3g greases：1), 0.8g thickeners (polyacrylic acid
Sodium) and sodium-chloride water solution 83.9g (mass concentration of sodium-chloride water solution is 0.9%)；
(2) Sodium Hyaluronate, thickener are well mixed with NMF；
(3) trehalose is mixed with sodium-chloride water solution, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 85 DEG C, adds grease, stirs 20 points
Clock；
(5) 40 DEG C are cooled to, is produced.
Compare 6 groups：
(1) 0.3g molecular weight is referred to as 200000~300000 Sodium Hyaluronate, 2g trehaloses, 10g NMF (glycerine：
Butanediol=2:3), (Butyrospermum parkii fruit fat and shea butter ratio are 1 to 3g greases：1), 0.8g thickeners (Sodium Polyacrylate) and
Sodium-chloride water solution 83.9g (mass concentration of sodium-chloride water solution is 0.9%)；
(2) Sodium Hyaluronate, thickener are well mixed with NMF；
(3) trehalose is mixed with sodium-chloride water solution, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 85 DEG C, adds grease, stirs 20 points
Clock；
(5) 40 DEG C are cooled to, is produced.
Compare 7 groups：
(1) 0.3g molecular weight is referred to as 6000~8000 Sodium Hyaluronate, 2g trehaloses, 10g NMF (glycerine：Fourth two
Alcohol=2:3), (Butyrospermum parkii fruit fat and shea butter ratio are 1 to 3g greases：1), 0.8g thickeners (Sodium Polyacrylate) and chlorination
Sodium water solution 83.9g (mass concentration of sodium-chloride water solution is 0.9%)；
(2) Sodium Hyaluronate, thickener are well mixed with NMF；
(3) trehalose is mixed with sodium-chloride water solution, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 85 DEG C, adds grease, stirs 20 points
Clock；
(5) 40 DEG C are cooled to, is produced.
Compare 8 groups
(1) (mass ratio of middle-molecular-weihydroxyethyl Sodium Hyaluronate and macromolecule Sodium Hyaluronate is referred to as 0.3g Sodium Hyaluronates
3:1, the molecular weight of middle-molecular-weihydroxyethyl Sodium Hyaluronate is 300000-400000, and the molecular weight of macromolecule Sodium Hyaluronate is
1000000-1200000), 2g trehaloses, 10g NMF (glycerine：Butanediol=2:3), 3g greases (Butyrospermum parkii fruit fat and breast
Wooden fruit oil ratio is 1：1), 0.8g thickeners (Sodium Polyacrylate) and the sodium-chloride water solution 83.9g (quality of sodium-chloride water solution
0.9%) concentration is；
(2) Sodium Hyaluronate, thickener are well mixed with NMF；
(3) trehalose is mixed with sodium-chloride water solution, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 85 DEG C, adds grease, stirs 20 points
Clock；
(5) 40 DEG C are cooled to, is produced.
Compare 9 groups
(1) (mass ratio of macromolecule Sodium Hyaluronate and small-molecular-weight Sodium Hyaluronate is referred to as 0.3g Sodium Hyaluronates
4:13, the molecular weight of macromolecule Sodium Hyaluronate is 1200000-1400000, and the molecular weight of small-molecular-weight Sodium Hyaluronate is
5000-6000), 2g trehaloses, 10g NMF (glycerine：Butanediol=2:3), 3g greases (Butyrospermum parkii fruit fat and shea butter
Ratio is 1：1), (mass concentration of sodium-chloride water solution is by 0.8g thickeners (Sodium Polyacrylate) and sodium-chloride water solution 83.9g
0.9%)；
(2) Sodium Hyaluronate, thickener are well mixed with NMF；
(3) trehalose is mixed with sodium-chloride water solution, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 85 DEG C, adds grease, stirs 20 points
Clock；
(5) 40 DEG C are cooled to, is produced.
Compare 10 groups
(1) (mass ratio of middle-molecular-weihydroxyethyl Sodium Hyaluronate and small-molecular-weight Sodium Hyaluronate is referred to as 0.3g Sodium Hyaluronates
2:7, the molecular weight of middle-molecular-weihydroxyethyl Sodium Hyaluronate is 200000-300000, and the molecular weight of small-molecular-weight Sodium Hyaluronate is
6000-7000) 2g trehaloses, 10g NMF (glycerine：Butanediol=2:3), 3g greases (Butyrospermum parkii fruit fat and shea butter
Ratio is 1：1), (mass concentration of sodium-chloride water solution is by 0.8g thickeners (Sodium Polyacrylate) and sodium-chloride water solution 83.9g
0.9%)；
(2) Sodium Hyaluronate, thickener are well mixed with NMF；
(3) trehalose is mixed with sodium-chloride water solution, dissolves trehalose, obtain aqueous trehalose；
(4) mixture for preparing step (2) is added in aqueous trehalose, is heated to 85 DEG C, adds grease, stirs 20 points
Clock；
(5) 40 DEG C are cooled to, is produced.
Embodiment 11
Skin permeation test in vitro
The Kunming mouse that weight is 18-22g is taken, abdomen is sloughed with the sodium sulfide solution that mass concentration is 8% (g/mL)
Portion and back hair, take off neck and put to death, cut skin of abdomen respectively, remove fat and hypodermis on skin, use physiological saline
Repeated multiple times flushing, filter paper blot surface moisture, and with the repeated multiple times flushing of physiological saline, filter paper blots surface moisture, is placed in life
Manage in salt solution, 4 DEG C of refrigerators save backup.
Water is added in Transdermal Absorption test instrument thermostat, setting water temperature in thermostat, as (37 ± 0.1) DEG C, setting connects
The magnetic stirring speed of receives pond rotor is 40r/min, and the skin of mouse is fixed on to confession medicine pond and the reception tank of diffusion with clip
Between, stratum corneum side is upward, and skin corium downwards, drains bubble.
0.5mL experiment products (facial mask liquid and comparison liquid prepared by each embodiment) are taken to drop on mouse skin, area is about
1cm2, respectively at 1h, 2h, 4h, 6h, the liquid 1ml in reception tank is taken, and supplied with purified water into reception tank.
According to《Chinese Pharmacopoeia (the 4th)》The method of (2015 editions) is measured with HPLC to the content of trehalose.Calculate
Accumulative transdermal absorption factor.
This experiment has following experimental group：6 groups of embodiment, 7 groups of embodiment, 8 groups of embodiment, 9 groups of embodiment, embodiment 10
Group, 1 group is compareed, 2 groups is compareed, compares 3 groups, compare 4 groups, compare 5 groups, compare 6 groups, compare 7 groups, compare 8 groups, compare 9 groups, be right
According to 10 groups.
Table 1, skin permeation test in vitro trehalose transmitance
| 1h | 2h | 4h | 6h | |
| Compare 1 group | 1.25% | 8.75% | 15.39% | 21.42% |
| Compare 2 groups | 1.21% | 9.64% | 15.52% | 40.38% |
| Compare 3 groups | 1.26% | 10.48% | 16.46% | 40.29% |
| Compare 4 groups | 1.37% | 10.36% | 16.73% | 41.09% |
| Compare 5 groups | 1.42% | 17.39% | 26.09% | 41.28% |
| Compare 6 groups | 1.56% | 17.46% | 25.79% | 41.35% |
| Compare 7 groups | 1.43% | 17.39% | 27.58% | 41.21% |
| Compare 8 groups | 1.68% | 17.77% | 27.84% | 41.63% |
| Compare 9 groups | 1.75% | 17.62 | 27.49% | 41.73% |
| Compare 10 groups | 1.81% | 17.71 | 27.43% | 41.62% |
| 6 groups of embodiment | 7.26% | 21.27% | 39.16% | 52.48% |
| 7 groups of embodiment | 6.38% | 21.39% | 39.49% | 53.41% |
| 8 groups of embodiment | 9.04% | 23.11% | 40.16% | 54.17% |
| 9 groups of embodiment | 7.39% | 21.18% | 39.52% | 52.80% |
| 10 groups of embodiment | 7.41% | 21.68% | 39.38% | 52.61% |
As can be seen from the above table, the composition of sebum film reparation of the invention, the preferable percutaneous absorbtion of energy, and the time is longer
Effect is better, add up transit dose it is higher, though and compareing 1-10 groups has the transdermal absorption of hyaluronic acid, from the saturating of any time period
Composition transmitance from the point of view of skin absorptivity without the present invention is high.
Embodiment 12
Skin moisture-keeping degree is measured using CK skinanalysis apparatus.
The people of volunteer 300 is selected, is randomly divided into 15 groups, every group of 20 people volunteers clean arm, dry, measurement now skin
Basic value, experiment product (facial mask liquid and comparison liquid prepared by each embodiment) 0.05mL is taken uniformly to be applied to 1cm2Skin on, survey
Measure 0h, 1h, 2h, 4h skin moisture-keeping.
Table 2, moistening effect result of the test
*Compared with 1 group of control, P ＜ 0.05
△ is with compareing 2 groups of ratios, P ＜ 0.05
It is slightly good that 1,2,3,4 group of moistening effect instant after smearing is compareed it can be seen from the present invention, control 5-10 groups are selected
The Sodium Hyaluronate of different molecular weight can also reach good moistening effect, but embodiment 6-10 groups are excellent from data
In control 5-10 groups.
Embodiment 13
The clinical verification of the present invention is chosen at the beautifying medical mechanism people such as hospital and changes skin, micro- whole through facial laser, tartaric acid
The damaged skin caused by reason such as skin and sensitive, dermatitis after the invasive surgeries such as shape.In 300 sufferers of clinic
In, women 186, male 114, the age is 18-60 year.15 groups are randomly divided into, every group of 20 people.
This experiment has following experimental group：6 groups of embodiment；7 groups of embodiment；8 groups of embodiment；9 groups of embodiment；Embodiment 10
Group；Compare 1 group；Compare 2 groups；Compare 3 groups；Compare 4 groups；Compare 5 groups；Compare 6 groups；Compare 7 groups；Compare 8 groups；Compare 9 groups；It is right
According to 10 groups.
Application method：(1) based process：Clean cutaneous lesion.(2) it is grouped usage：After based process, using product,
1st day to the 10th day, use 1 time daily, the 10th day to 20 days, every other day using 1 time, each application time was 20 minutes.
Health giving quality index：Carried out with reference to the sensitive dermatitis standard of face[1,2]Symptom score:Itch, erythema, oedema, ooze out, do
Dry furfur, shouting pain, pigmentation press respectively without, it is light, in, restatement be 0-3 points.
Note：[1] clinical research [D] the Shandong Traditional Chinese Medicine University of beautiful antipruritic skin gels treatment facial dermatitis is opened, 2012.
[2] Liu Dongmei, Shen Weilu, Wang Kun, faces clinical treatment [J] the China traditional Chinese and western medicine sensitive through changing skin and tender skin postoperative skin is waited
With reference to skin cypridology magazine, 2012,11 (6):365-367.
According to pretherapy and post-treatment symptom, somatic feature score, reference《New Chinese medicine guideline of clinical investigations》, enter by following standard
Row therapeutic evaluation：
Recovery from illness:Symptom, somatic feature score reduce >=95%.
It is effective:Ache symptom, somatic feature score reduction >=70%,<95%.
Effectively:Symptom, somatic feature score reduce >=30%,<70%.
It is invalid:Symptom, sign are reduced less than 30%.
Recovery from illness+effective+effective number of cases calculates total effective rate.
Calculation formula is：[being integrated before (being integrated before treatment after integration-treatment)/treatment] × 100%.
Safety evaluatio：
In normal conditions of use, by the clinical practice of subject, the generation of adverse events is determined whether, and according to not
The degree of good event, and vital sign check for exception, and Product Safety is evaluated.
I levels：Safety, without any adverse events, vital sign checks without exception.
II grade：Compare safety, there is slight adverse events, be not required to do any processing can continual cure, vital sign checks nothing
It is abnormal.
III grade：There is safety issue, there are moderate adverse events, can continual cure or vital sign inspection after processing
Mile abnormality is looked into.
IV grade：Because serious adverse events stop to test, or vital sign checks obvious exception.
The experimental result of table 3
| Use medicine | Case load | Recovery from illness | It is effective | Effectively | It is invalid | It is efficient | Safety evaluatio |
| Compare 1 group | 20 | 3 | 5 | 6 | 6 | 35.00% | II grade |
| Compare 2 groups | 20 | 2 | 2 | 5 | 11 | 45.00% | II grade |
| Compare 3 groups | 20 | 2 | 3 | 3 | 12 | 40.00% | II grade |
| Compare 4 groups | 20 | 2 | 3 | 2 | 13 | 35.00% | II grade |
| Compare 5 groups | 20 | 6 | 4 | 3 | 7 | 65.00% | II grade |
| Compare 6 groups | 20 | 7 | 3 | 3 | 7 | 65.00% | I levels |
| Compare 7 groups | 20 | 5 | 4 | 6 | 7 | 65.00% | I levels |
| Compare 8 groups | 20 | 6 | 4 | 4 | 6 | 70.00% | I levels |
| Compare 9 groups | 20 | 6 | 5 | 3 | 6 | 70.00% | I levels |
| Compare 10 groups | 20 | 5 | 4 | 5 | 6 | 70.00% | I levels |
| 6 groups of embodiment | 20 | 10 | 3 | 3 | 2 | 90.00% | I levels |
| 7 groups of embodiment | 20 | 15 | 1 | 2 | 2 | 90.00% | I levels |
| 8 groups of embodiment | 20 | 16 | 1 | 2 | 1 | 95.00% | I levels |
| 9 groups of embodiment | 20 | 15 | 2 | 1 | 2 | 90.00% | I levels |
| 10 groups of embodiment | 20 | 15 | 1 | 2 | 2 | 90.00% | I levels |
The product effective percentage of the present invention achieves certain treatment more than 90.00% it can be seen from above-mentioned clinical test
Effect, the using effect of wherein embodiment 6-10 groups is more preferable than control group effect, further illustrates the sebum film reparation of the present invention
Composition is for skin of the people after facial laser, tartaric acid change the invasive surgeries such as skin, micro-shaping and sensitive, dermatitis etc.
Damaged skin caused by reason has good effect.
Safety evaluatio result：Adverse events do not occur for embodiment 6-10 groups, control 6-10 groups, and vital sign checks nothing
Abnormal, 1 group of control has the red and swollen aggravation of 2 patients' appearance or face punctation occur, is taken a turn for the better after drug withdrawal；Compareing 2 groups has 3 trouble
Person occurs drying furfur symptom, is taken a turn for the better after processing；Compareing 3 groups has 2 patients facial red heat occur, and pain is good after processing
Turn；Compareing 4 groups has 1 patient facial swelling occur, is taken a turn for the better after drug withdrawal；Compareing 5 groups has 1 patient facial region punctation occur
And slippers situation, taken a turn for the better after processing.
Claims (5)
- A kind of 1. sebum film maintenance composition, it is characterized in that being made up by mass percentage of following raw materials：Sodium Hyaluronate 0.1%-1%, trehalose 0.2%-4%, NMF 2%-15%, grease 1%-10%, thickener 0.1%-1% and solution 80%-83.9%, the solution is the D/W that mass concentration is 1%-3% or mass concentration is 0.3%-1.2% Sodium-chloride water solution；The Sodium Hyaluronate is 1 by mass ratio:(2~5):The molecular weight ranges of (5~30) are 1000000 ~2000000 macromolecule Sodium Hyaluronate, the middle numerator sodium hyaluronate of molecular weight ranges 100000~400000 and point Son amount scope forms in 5000~10000 micromolecule hyaluronic acid sodium.
- 2. a kind of sebum film maintenance composition according to claim 1, it is characterized in that the NMF is glycerine, the third two One or more in alcohol, 1,3-BDO.
- A kind of 3. sebum film maintenance composition according to claim 1, it is characterized in that the grease is shea butter, butter At least one of fruit tree fruit fat and olive oil.
- A kind of 4. sebum film maintenance composition according to claim 1, it is characterized in that the thickener is Sodium Polyacrylate At least one of with carbomer.
- 5. the gel of one of 1-4 containing claim sebum film maintenance composition, it is characterized in that being made of following methods：(1) Sodium Hyaluronate, thickener are well mixed with NMF；(2) trehalose is mixed with solution, dissolves trehalose, obtain aqueous trehalose；(3) mixture for preparing step (1) is added in aqueous trehalose, is heated to 80-90 DEG C, adds grease, stirs 10-30 Minute；(4) 30-40 DEG C is cooled to, is produced.
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| CN105963204B (en) * | 2016-06-27 | 2020-08-21 | 中国人民解放军总医院 | Moisturizing and anti-allergic repair mask and preparation method thereof |
| CN107375032B (en) * | 2017-08-11 | 2021-02-19 | 天津嘉氏堂科技有限公司 | Composition for repairing skin barrier and preparation method thereof |
| CN108042441A (en) * | 2018-02-13 | 2018-05-18 | 沈阳姿上元生物科技有限责任公司 | It is a kind of that there is moisturizing, antibacterial, repair composition and application product and preparation method |
| CN111467561B (en) * | 2020-05-21 | 2020-12-11 | 绽妍生物科技有限公司 | Dressing containing trehalose and capable of repairing skin screen and manufacturing process of dressing |
| CN112353800B (en) * | 2020-11-10 | 2022-06-24 | 华熙生物科技股份有限公司 | Composition of hyaluronic acid or salt thereof and/or trehalose and use thereof in stabilizing ergothioneine |
| CN114732844B (en) * | 2021-11-09 | 2023-05-16 | 西安润玉医疗科技有限公司 | Bionic membrane composition capable of immediately relaxing and preparing method thereof |
| CN114796012B (en) * | 2022-04-08 | 2024-03-29 | 华熙生物科技股份有限公司 | Hyaluronic acid sebum membrane composition and preparation method thereof |
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