CN106215244A - The compound recipe solution of hyaluronate sodium and the application of correction wrinkle of skin thereof - Google Patents
The compound recipe solution of hyaluronate sodium and the application of correction wrinkle of skin thereof Download PDFInfo
- Publication number
- CN106215244A CN106215244A CN201610627499.8A CN201610627499A CN106215244A CN 106215244 A CN106215244 A CN 106215244A CN 201610627499 A CN201610627499 A CN 201610627499A CN 106215244 A CN106215244 A CN 106215244A
- Authority
- CN
- China
- Prior art keywords
- skin
- compound recipe
- solution
- wrinkle
- hyaluronate sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/214—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to the compound recipe solution of a kind of hyaluronate sodium and correct the application of wrinkle of skin, it is the compound recipe solution with hyaluronate sodium, L carnosine, aminoacid and water soluble vitamins as main component.Including: hyaluronate sodium 1.000 ~ 5.000 mg/m L；L carnosine L 1.000 ~ 2.000 mg/m L；Aminoacid 0.100 ~ 0.500mg/ m L；Water-soluble (vitamin) B 2 0.001 0.005mg/mL；PH value 7 7.2.This product can supplement extracellular matrix to skin, promotes the synthesis of skin collagen, plays the effect correcting wrinkle.Compound recipe solution of the present invention, through clinical trial, shows that it can be used for correcting wrinkle, and safety is high, without significant complications.
Description
Technical field
The present invention relates to the compound recipe solution of a kind of hyaluronate sodium and correct the application of wrinkle of skin, it is with hyalomitome
Acid sodium, N-BETA-Alanyl-L-histidine, aminoacid and the compound recipe solution that water soluble vitamins is main component.This product can supplement the outer base of born of the same parents to skin
Matter, promotes the synthesis of skin collagen, plays the effect correcting wrinkle.
Background technology
Along with the age is old and feeble and the impact of photoaging, hyaluronic acid in corium, chondroitin sulfate, collagen etc. flow gradually
Losing, skin follows the string.In this process, cervical region aging is particularly acute, and can produce the wrinkle in some horizontal directions.It is former
Because being: the thickness of skin of neck only has the 2/3 of face, it is sebaceous gland and the minimum place of sweat gland, and collagen content
Few, subcutaneous layer of fat is thin.
Containing multiple macromolecule polysaccharide in the extracellular matrix of skin, such as hyaluronic acid, chondroitin sulfate.The knot of hyaluronic acid
Structure unit is D-Glucose aldehydic acid and the disaccharidase of N-acetyl-glucosamine composition, has extremely strong water retention property, is present in and includes skin
Skin is in interior most of soft connective tissues, and wherein in skin, content is about 2.5mg/mL.Growth and environment along with people's age
The impact of Factors Factor, the ability of human body synthesis hyaluronic acid is gradually reduced, and in skin, the content of hyaluronic acid can be gradually lowered.
Chondroitin sulfate is a kind of acid mucopolysaccharide, and generally presented in glycoprotein in animal body, its construction unit is N-second
The disaccharidase that acylamino-galactose and glucuronic acid are constituted, according to the position difference chondroitin sulfate of sulfate group can be divided into A, B,
C tri-kinds.Chondroitin sulfate is a kind of important component in skin extracellular matrix, minimizing phenomenon occurs with the aging of skin.
Hyaluronic acid is for correcting the existing longer history of wrinkle, and mainly its cross-linked form of utilization, is nasolabial fold
The common materials filled with forehead wrinkle.Skin of neck epidermis is relatively thin, presses pressing massage difficulty relatively greatly after injection cross-linked transparent acid sodium,
Easily form rough situation；It is i.e. platysma it addition, subcutaneous, if injection level is improper at Musclar layer, the most accidentally
Form bar rope sense.The appearance of above-mentioned situation all can have a strong impact on attractive in appearance, loses therapeutic effect, and therefore cross-linking hyaluronic acid sodium is uncomfortable
Correct for neck stricture of vagina.
Non-crosslinked hyaluronate sodium do not have crosslinking hyaluronic acid sodium above-mentioned side effect, but non-crosslinked hyaluronate sodium
Under free radical and hyaluronidase effect, the half-life in skin is short, is easily degraded.
N-BETA-Alanyl-L-histidine contained by correction a crease in the skin injection in Chinese patent CN 104189952 A has antioxygen and is turned into
With, can effectively suppress the degraded of radical pair hyaluronate sodium.Help additionally by addition amino acid, vitamine etc. and promote into
Fibrocellular collagen secretion, the collagen protein lost during supplementing skin aging.
Summary of the invention
It is an object of the invention to provide the compound recipe solution of a kind of hyaluronate sodium and correct the application of wrinkle of skin.This is multiple
Side's solution mainly forms with macromolecule polysaccharide hyaluronate sodium, aminoacid, water soluble vitamins and N-BETA-Alanyl-L-histidine for material combination.
The present invention provide compound recipe solution have compare pure hyaluronic acid sodium solution degradation time longer and correct neck stricture of vagina persistency more preferable
Feature;Especially, the compound recipe solution that the present invention provides does not results in the phenomenon of the tuberosity of neck stricture of vagina.
The compound recipe solution of the hyaluronate sodium that the present invention provides includes:
Hyaluronate sodium 1.000 ~ 5.000 mg/m L
N-BETA-Alanyl-L-histidine L 1.000 ~ 2.000 mg/m L
Aminoacid 0.100 ~ 0.500mg/ m L
Water-soluble (vitamin) B 2 0.001-0.005mg/mL
PH value 7-7.2.
Above-mentioned compound recipe solution compound method is by formula metering obtained aqueous solution, mix homogeneously；Treat during preparation that each component is complete
After CL, then regulate pH value, then through 0.2 μm filter filtration sterilization.
Wrinkle of skin is corrected in the compound recipe solution application of the hyaluronate sodium that the present invention provides, and including shrunken skin, relaxes,
Correction especially for position wrinkles such as cervical region, face and hands.
The using method of the compound recipe solution of the hyaluronate sodium that the present invention provides: correct wrinkle of skin injection for cervical region
Time, skin at neck stricture of vagina should be tightened, choose multiple spot, penetrate to skin corium, limit withdraw of the needle marginal not along neck stricture of vagina direction inserting needle, push away agent on a small quantity and formed
Skin mound.
The compound recipe solution of the hyaluronate sodium that the present invention provides includes mainly treating for the evaluation criterion of neck stricture of vagina error-correcting effect
Effect index and secondary efficacy index.Curative effect index: use wrinkle classification of severity (WAS) evaluate before injection for curing with control
After treatment, the scoring change effective percentage of 12 weeks wrinkles reflects the effect for the treatment of.Improvement rate computational methods: deduct with baseline WAS scoring
WAS scoring in 12nd week after treatment, is that effectively effective number of cases obtains improvement rate divided by total number of cases as difference is more than or equal to 1.Secondary
Curative effect index: treat the 1st week and the scoring changing value of WAS of the 4th week researcher assessment and improvement rate；Treat the 1st week, the 4th week
And the WAS scoring changing value of the 12nd week experimenter assessment and improvement rate；Treat the 1st week, the 4th week and researcher assessment in the 12nd week
GAIS marks；Treat the 1st week, the 4th week and the GAIS scoring of experimenter's assessment in the 12nd week；Treat third party's assessment in the 12nd week
WAS scoring changing value and improvement rate.
The compound recipe solution of the hyaluronate sodium that the present invention provides is for the correction of wrinkle.Wherein, macromolecule polysaccharide can play
Filling effect, plays the effect correcting neck stricture of vagina；The N-BETA-Alanyl-L-histidine with antioxidation can suppress radical pair hyaluronate sodium
Degraded, increases its degradation time；Aminoacid and vitamin component help the synthesis promoting self collagen albumen, recover skin aging
During lose collagen protein.The present invention have compare pure hyaluronic acid sodium solution degradation time longer and correct neck stricture of vagina lasting
The more preferable feature of property;Especially, the compound recipe solution that the present invention provides does not results in the phenomenon of the tuberosity of neck stricture of vagina.Through clinical trial,
Show that it can be used for correcting wrinkle, and safety is high, without significant complications.
Accompanying drawing explanation
Fig. 1 injects design sketch before and after compound recipe solution.
Fig. 2 injects design sketch before and after pure hyaluronic acid sodium solution.
Detailed description of the invention
Embodiment 1: compound recipe solution can be effective against the degraded of free radical compared to pure hyaluronic acid sodium solution.
Sample preparation
Compound recipe solution: prepare 5.000 mg/mL hyaluronate sodiums, the N-BETA-Alanyl-L-histidine of 2.000mg/mL, 0.100mg/mL glycine,
0.200mg/mL proline, 0.100mg/mL alanine and 0.005mg/mL vitamin B2 solution；Treat during preparation that each component is complete
After dissolving, regulation pH value is to 7.2.
Pure hyaluronic acid sodium solution: prepare 5.000 mg/mL hyaluronate sodiums；During preparation after it is completely dissolved, regulation
PH value is to 7.2.
Experiment material: copper sulphate pentahydrate, 30% hydrogen peroxide, hyaluronate sodium, N-BETA-Alanyl-L-histidine, glycine, alanine, proline,
Vitamin B2,1M hydrochloric acid, Ox blood serum, potassium acetate, glacial acetic acid, sodium chloride, purified water.
Experimental technique:
Take 1.0mL sodium hyaluronate solution, 1.0mL sodium hyaluronate solution and 1.0mL compound recipe solution, numbered A, B and C
Three groups；
0.2mL purified water is added, to B group and the copper sulfate of 100mM of C group addition 0.1mL and the 100mM of 0.1 to A group
Hydrogen peroxide.
A, B and C tri-groups is placed in 37 DEG C of water-bath reaction 1h, and separately sampled dilution 20 times is to be measured.
Measuring method:
Acetic acid-potassium acetate buffer: take potassium acetate 14g, glacial acetic acid 20.5mL, add water and be diluted to 1000mL.
Serum solution: take fresh bovine serum 1 part, adds acetic acid-potassium acetate buffer 9 parts dilution, then with 4mol/L hydrochloric acid
Solution regulation p H value, to 3 .1, after placing 18 24 hours, dilutes 3 times with acetic acid-liquor kalii acetici.
Take aforementioned liquid to be measured add 4mL serum solution, take simultaneously 1mL purified water add 4mL as blank, shake up,
Place 30 minutes in room temperature, shake up, at the wavelength of 640mn, measure absorbance, calculate the degradation rate of each group according to absorbance.
Experimental result:
The degradation rate (meansigma methods, n=5) of hyaluronate sodium respectively organized by table 1
| A group | B group | C group |
| 100.0% | 21.2% | 87.6% |
Embodiment 2: compound recipe solution has longer degradation cycle compared to pure hyaluronic acid sodium solution
Sample preparation:
Compound recipe solution: prepare 5.000 mg/mL hyaluronate sodiums, the N-BETA-Alanyl-L-histidine of 2.000mg/mL, 0.100mg/mL glycine,
0.200mg/mL proline, 0.100mg/mL alanine and 0.005mg/mL vitamin B2 solution；Treat during preparation that each component is complete
After dissolving, regulation pH value is to 7.2, for zoopery after 0.2 μm filter filtration sterilization.
Pure hyaluronic acid sodium solution: preparation 7.400mg/mL sodium hyaluronate solution；During preparation after component is dissolved, regulation
PH value is to 7.2, for zoopery after 0.2 μm filter filtration sterilization.
Laboratory animal: the BALB/c mouse at 7 ~ 8 monthly ages.
Experimental technique:
48 mices are randomly divided into 4 groups, and often group 12, respectively injects latter 7 days detection groups, injects latter 30 days detection groups, note
Penetrate latter 90 days detection groups.Shed in the mouse back spinal column left and right sides, after 75% alcohol disinfecting, and left side injected sample compound recipe solution, right
Side injection sample pure hyaluronic acid solution.At test point, put to death laboratory animal, cut injection site open, observe sample carryover situation.
Experimental result:
| Time | Pure hyaluronic acid sodium solution | Compound recipe solution |
| 7 days | Noresidue | There is residual |
| 30 days | Noresidue | There is residual |
| 90 days | Noresidue | Noresidue |
Case study on implementation three: compound recipe solution has more preferable neck stricture of vagina filling effect compared to pure hyaluronic acid sodium solution
For evaluating the effectiveness of compound recipe solution, we test in neck stricture of vagina patient, to evaluate clinical power and safety.
Clinical method:
Injecting method: use 30G × 1/2 syringe needle, skin at neck stricture of vagina should be tightened during injection, choose multiple spot, by sample along neck stricture of vagina
Direction inserting needle is penetrated to skin corium, limit withdraw of the needle marginal not, injects formation skin mound on a small quantity.
Test method: before injection, injection after, injection 12 weeks time shoot cervical region normotopia photo.Stay after injection and see half an hour,
Make a house call in 1 week, 4 weeks and 12 weeks, wherein screening and injection after 12 weeks time carry out lab testing.Process of the test patient is divided into experiment
Group and matched group, experimental group compound recipe solution, matched group injection pure hyaluronic acid sodium solution.
Efficiency evaluation standard:
Curative effect index: use wrinkle classification of severity (WAS) evaluate before injection for curing with treatment after the commenting of 12 weeks wrinkles
Change effective percentage is divided to reflect the effect for the treatment of.Improvement rate computational methods: mark with baseline WAS and deduct the 12nd week WAS after treatment
Scoring, is that effectively effective number of cases obtains improvement rate divided by total number of cases as difference is more than or equal to 1.
Secondary efficacy index:
Treat the 1st week and the scoring changing value of WAS of the 4th week researcher assessment and improvement rate；Treat the 1st week, the 4th week and the 12nd
The WAS scoring changing value of week experimenter's assessment and improvement rate；Treat the 1st week, the 4th week and the GAIS of the 12nd week researcher assessment
Scoring；Treat the 1st week, the 4th week and the GAIS scoring of the 12nd week experimenter assessment；The WAS treating third party's assessment in the 12nd week comments
Divide changing value and improvement rate.
Neck stricture of vagina evaluation criterion (WAS)
| Fraction | Degree | Describe |
| 1 fraction | Nothing | Without visible wrinkle, only see continuous print skin streakline |
| 2 fraction | Slightly | Gauffer is shallow, but visible, in slight indenture. |
| 3 fraction | Moderate | Deep gauffer, cervical region scrimp is clear；Scrimp is visible in the ordinary course of things, but scrimp disappears when extended. |
| 4 fraction | Seriously | Very long and deep fold, scrimp is notable |
| 5 fraction | The most serious | Profound and long wrinkle, and have the pendant shape fold that hangs down |
Overall situation cosmetic result fraction (GAIS)
| Classification | Describe |
| 1 fraction | Improve clearly |
| 2 fraction | Improve substantially |
| 3 fraction | Have and to a certain degree improve |
| 4 fraction | It is not changed in |
| 5 fraction | More even worse than in the past |
Safety observation index
Before injection, to inject latter 3 months routine blood tests, blood biochemistry the most normal；Check before injection whether urine gestation is negative；Short-term is stung
Swash (normal injection be all likely to occur can the local response of natural fading, evaluate include touching lump, pin trace, redness, erythema,
Pain and complication)；Causal adverse events is had with apparatus.
Clinical study results:
Efficiency evaluation
Injection operation is simple, and pain is little, and treatment cycle is short.It is tight that the test group of researcher evaluation is respectively arranged with time point Neck wrinkles of making a house call
Weight degree scoring (WAS) display, after injection 1 week, 4 weeks and the change of 12 weeks WAS grade scorings relatively inject one classification of front reduction and
Above person respectively reaches 97.5%, 82.5% and 62.5%, determined curative effect.The matched group of researcher evaluation is respectively made a house call time point cervical region
Wrinkle severity scores (WAS), the injection Later Zhou Dynasty, one of the Five Dynasties, 4 weeks and the change of 12 weeks WAS grade scorings relatively injection one classification of front reduction and more than
Person respectively reaches 95.0%, 42.5% and 25.0%.Part efficacy result is shown in accompanying drawing 1 and Fig. 2.
Safety evaluatio
By clinical observation, injection compound recipe sodium hyaluronate solution short-term local response is slight, and safety is higher.
Claims (3)
1. the compound recipe solution of a hyaluronate sodium, it is characterised in that its composition:
Hyaluronate sodium 1.000 ~ 5.000 mg/m L
N-BETA-Alanyl-L-histidine L 1.000 ~ 2.000 mg/m L
Aminoacid 0.100 ~ 0.500mg/ m L
Water soluble vitamins 0.001-0.005mg/mL
PH value 7-7.2.
2. according to the compound recipe solution of the hyaluronate sodium described in claim 1, it is characterised in that its composition:
Hyaluronate sodium 5.000 mg/m L
N-BETA-Alanyl-L-histidine 2.000mg/mL
Glycine 0.100mg/mL
Proline 0.200mg/mL
Alanine 0.100mg/mL
Vitamin B2 0.005mg/mL
PH value=7.2.
3. the application of the compound recipe solution of the hyaluronate sodium described in claim 1 or 2, it is characterised in that it is used for cervical region, face
Correction with position wrinkles such as hands.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610627499.8A CN106215244A (en) | 2016-08-03 | 2016-08-03 | The compound recipe solution of hyaluronate sodium and the application of correction wrinkle of skin thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610627499.8A CN106215244A (en) | 2016-08-03 | 2016-08-03 | The compound recipe solution of hyaluronate sodium and the application of correction wrinkle of skin thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106215244A true CN106215244A (en) | 2016-12-14 |
Family
ID=57536442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610627499.8A Pending CN106215244A (en) | 2016-08-03 | 2016-08-03 | The compound recipe solution of hyaluronate sodium and the application of correction wrinkle of skin thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106215244A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308101A (en) * | 2017-06-13 | 2017-11-03 | 湖南御家化妆品制造有限公司 | Skin tightening composition and application thereof |
| CN110339398A (en) * | 2019-07-18 | 2019-10-18 | 王月玲 | One kind Amvisc containing amino acid and preparation method thereof |
| CN111467568A (en) * | 2019-01-23 | 2020-07-31 | 爱美客技术发展股份有限公司 | Cross-linked sodium hyaluronate composite solution preparation and preparation method and application thereof |
| CN113117144A (en) * | 2019-12-30 | 2021-07-16 | 上海建华精细生物制品有限公司 | Bionic dermis importing solution and application thereof |
| CN113813198A (en) * | 2021-09-24 | 2021-12-21 | 西安莲韵医疗美容医院有限公司 | Nutrient solution for improving facial wrinkles and firming skin and preparation method thereof |
| CN114712264A (en) * | 2022-06-08 | 2022-07-08 | 南京天纵易康生物科技股份有限公司 | Synergistic and stable sodium hyaluronate composite solution composition and preparation thereof |
| CN115944553A (en) * | 2022-12-07 | 2023-04-11 | 华熙生物科技股份有限公司 | Application of oligopeptide in improving stability of cross-linked hyaluronic acid or salt thereof |
| CN116098827A (en) * | 2022-12-07 | 2023-05-12 | 华熙生物科技股份有限公司 | Use of oligopeptides for improving vitamin and/or amino acid stability |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103282032A (en) * | 2010-12-06 | 2013-09-04 | 詹弗兰科·德保利安布罗西 | Carnosine-hyaluronic acid mixtures and their use |
| CN104086788A (en) * | 2014-07-17 | 2014-10-08 | 华熙福瑞达生物医药有限公司 | Modified sodium hyaluronate gel for injection |
| CN104189952A (en) * | 2014-08-05 | 2014-12-10 | 北京爱美客生物科技有限公司 | Injection for correcting skin wrinkles and preparation method thereof |
-
2016
- 2016-08-03 CN CN201610627499.8A patent/CN106215244A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103282032A (en) * | 2010-12-06 | 2013-09-04 | 詹弗兰科·德保利安布罗西 | Carnosine-hyaluronic acid mixtures and their use |
| CN104086788A (en) * | 2014-07-17 | 2014-10-08 | 华熙福瑞达生物医药有限公司 | Modified sodium hyaluronate gel for injection |
| CN104189952A (en) * | 2014-08-05 | 2014-12-10 | 北京爱美客生物科技有限公司 | Injection for correcting skin wrinkles and preparation method thereof |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308101A (en) * | 2017-06-13 | 2017-11-03 | 湖南御家化妆品制造有限公司 | Skin tightening composition and application thereof |
| CN107308101B (en) * | 2017-06-13 | 2020-06-19 | 湖南御家化妆品制造有限公司 | Skin tightening composition and application thereof |
| CN111467568A (en) * | 2019-01-23 | 2020-07-31 | 爱美客技术发展股份有限公司 | Cross-linked sodium hyaluronate composite solution preparation and preparation method and application thereof |
| CN111467568B (en) * | 2019-01-23 | 2022-04-15 | 爱美客技术发展股份有限公司 | Cross-linked sodium hyaluronate composite solution preparation and preparation method and application thereof |
| CN110339398A (en) * | 2019-07-18 | 2019-10-18 | 王月玲 | One kind Amvisc containing amino acid and preparation method thereof |
| CN113117144A (en) * | 2019-12-30 | 2021-07-16 | 上海建华精细生物制品有限公司 | Bionic dermis importing solution and application thereof |
| CN113813198A (en) * | 2021-09-24 | 2021-12-21 | 西安莲韵医疗美容医院有限公司 | Nutrient solution for improving facial wrinkles and firming skin and preparation method thereof |
| CN114712264A (en) * | 2022-06-08 | 2022-07-08 | 南京天纵易康生物科技股份有限公司 | Synergistic and stable sodium hyaluronate composite solution composition and preparation thereof |
| CN114712264B (en) * | 2022-06-08 | 2022-09-09 | 南京天纵易康生物科技股份有限公司 | Synergistic stable sodium hyaluronate composite solution composition and preparation thereof |
| CN115944553A (en) * | 2022-12-07 | 2023-04-11 | 华熙生物科技股份有限公司 | Application of oligopeptide in improving stability of cross-linked hyaluronic acid or salt thereof |
| CN116098827A (en) * | 2022-12-07 | 2023-05-12 | 华熙生物科技股份有限公司 | Use of oligopeptides for improving vitamin and/or amino acid stability |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106215244A (en) | The compound recipe solution of hyaluronate sodium and the application of correction wrinkle of skin thereof | |
| US20190300583A1 (en) | Neurotoxins for use in inhibiting cgrp | |
| CN105662916B (en) | Composition for repairing sebum membrane | |
| CN104189952B (en) | Correct a crease in the skin injection and preparation method thereof | |
| CN105748315B (en) | Composition for repairing skin barrier | |
| US20070293427A1 (en) | Hydrolysate of avian cartilage, process of preparation and uses thereof | |
| JP7245960B2 (en) | Composition and its use in the manufacture of skin care products for regulating skin biorhythms | |
| CN106176292A (en) | A kind of biodegradable injection molding process decorative material and preparation method thereof | |
| CN105726366B (en) | Skin lipid membrane repairing composition | |
| KR102485261B1 (en) | Composition for maintaining effect of filler | |
| CN111297727A (en) | Beautifying and plasticizing treatment composition and application thereof | |
| CN109549893A (en) | A kind of preparation method with anti-blue light contamination and the composition repaired and essence cream and its essence cream | |
| CN107496310A (en) | A kind of facial treatment essence liquid and preparation method thereof | |
| JP2020511548A (en) | Botulinum neurotoxin for treatment | |
| CN110381976A (en) | Composition including peptide WKDEAGKPLVK | |
| CN107189119A (en) | A kind of preparation method and applications of compound sodium hyaluronate collagen hydrogels | |
| CN108836901A (en) | A kind of facial mask essence of the Product filtrate containing saccharomycetes to make fermentation and preparation method thereof | |
| CN108030721A (en) | A kind of Essence and preparation method thereof | |
| CN108158843A (en) | It is a kind of can the sodium hyaluronate stoste and preparation method thereof that imports of micropin | |
| Tak et al. | Effect of collagen tripeptide and adjusting for climate change on skin hydration in middle-aged women: A randomized, double-blind, placebo-controlled trial | |
| CN108904633A (en) | A kind of eye ointment and preparation method thereof improving eyesight | |
| CN107149583A (en) | A kind of anti-wrinkle cosmetic composition and its compound method | |
| CN109431850A (en) | A kind of application of Collagen type-I in cosmetic field | |
| JP2000102362A (en) | Food additive and food composition containing the same | |
| CN114903810B (en) | Peptide-containing anti-wrinkle composition and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161214 |
|
| WD01 | Invention patent application deemed withdrawn after publication |