CN108904633A - A kind of eye ointment and preparation method thereof improving eyesight - Google Patents
A kind of eye ointment and preparation method thereof improving eyesight Download PDFInfo
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Abstract
The present invention provides a kind of eye ointment and preparation method thereof for improving eyesight; first water phase is made in taurine and sialic acid by the present invention; oily phase is made in the deficient essential oil of fiber crops and evening primrose oil; then water phase and oil mix to obtain emulsion, finally introduce emulsion in the aquogel system that carboxymethyl chitosan and sodium alginate are constituted, obtain a kind of gelatinous Eye ointments; has the advantages that traditional eye ointment; sticky sense is reduced simultaneously, the sense of discomfort of traditional eye ointment is alleviated, can obviously improve eyesight.
Description
Technical field
The present invention relates to eye ointment technical fields, particularly, are related to a kind of eye ointment and preparation method thereof for improving eyesight.
Background technique
Eyes are the highly important organs of human body, due to bad habits various in people's daily life, are very easy to lead
It causes eyes many problems occur, and eventually leads to visual impairment.Asthenopia is to cause a common inducement of visual impairment.Sternly
The asthenopia of weight may cause eyes and inflammation occurs.Asthenopia has many symptoms, such as：Blurred vision, eyes are dry and astringent,
It sheds tears, or even headache, dizziness and conjunctival congestion etc..In addition to cultivate it is good with eye be accustomed to and carries out eye health exercise other than, borrow
It is often got twice the result with half the effort with the booster action of medicament.
Eye drops and eye ointment are two kinds of common eye-drops preparations.It is more comfortable after eye drip drop, without greasy feeling, will not occur
Situations such as retina obscures, but its retention time in conjunctival sac is short, and timing is needed to be used for multiple times.Eye ointment stops in conjunctival sac
Stay the time long, drug effect is more lasting than eye drops.But traditional Eye ointments has greasy feeling, using causing eyesight mould in the rear short time
Paste.Gel for eye alleviates the sense of discomfort of traditional Eye ointments as a kind of novel eye ointment preparation, is quite favored by patient.
There is the gel for eye of many immunotherapy targeted autoantibodies currently on the market, the curative effect in terms of simple improvement eyesight is not
It is satisfactory.
Summary of the invention
It is an object of that present invention to provide a kind of eye ointment and preparation method thereof for improving eyesight, to solve to improve using Eye ointments
The technical issues of eyesight.
To achieve the above object, the present invention provides a kind of preparation method of eye ointment for improving eyesight, specific step is as follows：
(1) taurine and sialic acid are scattered in the water of aqueous emulsifier phase, obtain water phase；
(2) the deficient essential oil of fiber crops and evening primrose oil are scattered in the saturation Triglyceride DDD containing oil phase emulsifier, obtain oily phase；
(3) by water phase with oily mutually with mass ratio 1：0.2~0.3 mixing, high-pressure homogeneous processing obtain emulsion；
(4) glacial acetic acid is added into sodium alginate aqueous solution, carboxymethyl chitosan sugar aqueous solution and step (3) are added after stirring evenly
Gained emulsion, stirs evenly, and is subsequently added into glutaraldehyde, stirs 12~14 hours；
(5) solidify to get.
Preferably, in step (1), taurine, sialic acid, aqueous emulsifier phase and water mass ratio be 1：0.2~0.3：1~
2：100~110.
Preferably, in step (1), the aqueous emulsifier phase is the mixture of PLURONICS F87, Tween 80 and sodium taurocholate,
Three's mass ratio is 1：0.2~0.3：0.3~0.4, compared with individually using one of which as aqueous emulsifier phase, hence it is evident that advantageous
In the uniform mixing of material, product uniformity is good, guarantees properties of product.
Preferably, in step (2), the deficient essential oil of fiber crops, evening primrose oil, oil phase emulsifier and the quality for being saturated Triglyceride DDD
Than being 1：0.5~0.8：1~2：100~110.
Preferably, in step (2), the oil phase emulsifier is the mixture of egg yolk lecithin and sorbester p17, the two quality
Than being 1：1.2~1.5, compared with individually using one of which as oil phase emulsifier, hence it is evident that be conducive to the uniform mixing of material,
Product uniformity is good, guarantees properties of product.
Preferably, in step (2), the deficient essential oil of fiber crops is prepared by the following method to obtain：The deficient plant of fresh fiber crops is taken, it is dry, it
It is impregnated in 45~65 DEG C of warm water afterwards 60~150 minutes, then ultrasonic echography is handled 30~60 minutes, is heated to boiling, be mentioned
It takes 2~3 hours, is extracted with ether, volatilize ether to obtain the final product.
It is further preferred that the deficient plant of fiber crops is selected from one of deficient fruit, pericarp, seed or stem of fiber crops or a variety of.
Preferably, in step (3), the process conditions of high-pressure homogeneous processing are：30~50MPa, 10~15 circulations.
Preferably, in step (4), the preparation method of sodium alginate aqueous solution is as follows：Sodium alginate is added to the water, 60~
70 DEG C stirring in water bath 2~3 hours, obtain sodium alginate aqueous solution；Wherein, the mass volume ratio of sodium alginate and water is 3g：
80mL。
Preferably, in step (4), the preparation method of carboxymethyl chitosan sugar aqueous solution is as follows：Carboxymethyl chitosan is dissolved in
In water, carboxymethyl chitosan sugar aqueous solution is made；Wherein, the mass volume ratio of carboxymethyl chitosan and water is 1g：70mL.
Preferably, in step (4), contained sodium alginate and glacial acetic acid in sodium alginate aqueous solution, glutaraldehyde, emulsion
Mass volume ratio is 3g：50mL：60mL：20~30mL.
Preferably, in step (5), cured process conditions are：20~30 DEG C are handled 80~100 minutes, then in ice bath
Under the conditions of handle 5~10 minutes.
Utilize a kind of eye ointment for improvement eyesight that above-mentioned preparation method obtains.
The invention has the advantages that：
First water phase is made in taurine and sialic acid by the present invention, and oily phase is made in the deficient essential oil of fiber crops and evening primrose oil, then water phase
It mixes to obtain emulsion with oil, emulsion is finally introduced into the aquogel system that carboxymethyl chitosan and sodium alginate are constituted
In, a kind of gelatinous Eye ointments is obtained, has the advantages that traditional eye ointment, while reducing sticky sense, alleviates traditional eye ointment
Sense of discomfort.Nerve conduction and visual function, protection retina can be improved in taurine, and sialic acid can prevent germ from invading, ox
Sulfonic acid and sialic acid act synergistically, and can play a good protective effect to ocular tissue, but sialic acid is used in above eyes
It can cause inflammation, the deficient essential oil of fiber crops and evening primrose oil all have certain anti-inflammatory activity, and the two collocation use can effectively reduce inflammation
Disease occurs, and fatigue is effectively relieved, hence it is evident that improves eyesight.
The present invention mixes after preparing water phase and oily phase respectively, is conducive to the uniform mixing of each material, and uniformity is good, guarantees to produce
Moral character energy.
On the one hand saturation Triglyceride DDD is used to disperse the deficient essential oil of fiber crops and on the other hand evening primrose oil is conducive to body
It is the reduction of viscosity, so that the sticky sense of product is reduced.
The selection of aqueous emulsifier phase and oil phase emulsifier is also more crucial, directly determines that the mixing of water phase and oily phase is equal
Even property, and then influence properties of product.
The present invention constitutes aquogel system using carboxymethyl chitosan and sodium alginate, without in addition addition preservative at
Point, i.e., it is with good stability.
Other than objects, features and advantages described above, there are also other objects, features and advantages by the present invention.
The present invention is further detailed explanation below.
Specific embodiment
The embodiment of the present invention is described in detail below, but the present invention can be limited and be covered according to claim
Multitude of different ways implement.
Evening primrose oil of the present invention is purchased from Guangzhou Xuan Yi flavors and fragrances Co., Ltd；Triglyceride DDD is saturated,
Purchased from Hou Man biotechnology (Shanghai) Co., Ltd..
Embodiment 1：
A kind of preparation method for the eye ointment improving eyesight, specific step is as follows：
(1) taurine and sialic acid are scattered in the water of aqueous emulsifier phase, obtain water phase；
(2) the deficient essential oil of fiber crops and evening primrose oil are scattered in the saturation Triglyceride DDD containing oil phase emulsifier, obtain oily phase；
(3) by water phase with oily mutually with mass ratio 1：0.2 mixing, high-pressure homogeneous processing obtain emulsion；
(4) glacial acetic acid is added into sodium alginate aqueous solution, carboxymethyl chitosan sugar aqueous solution and step (3) are added after stirring evenly
Gained emulsion, stirs evenly, and is subsequently added into glutaraldehyde, stirs 12 hours；
(5) solidify to get.
Wherein, in step (1), taurine, sialic acid, aqueous emulsifier phase and water mass ratio be 1：0.2：1：100.
In step (1), aqueous emulsifier phase is PLURONICS F87.
In step (2), the mass ratio that fiber crops owe essential oil, evening primrose oil, oil phase emulsifier and saturation Triglyceride DDD is 1：
0.5：1：100.
In step (2), oil phase emulsifier is egg yolk lecithin.
In step (2), the deficient essential oil of fiber crops is prepared by the following method to obtain：The deficient plant of fresh fiber crops is taken, it is dry, later at 45 DEG C
It is impregnated in warm water 60 minutes, then ultrasonic echography is handled 30 minutes, is heated to boiling, and is extracted 2 hours, is extracted, waved with ether
Dry diethyl ether to obtain the final product.
In step (3), the process conditions of high-pressure homogeneous processing are：30MPa, 10 circulations.
In step (4), the preparation method of sodium alginate aqueous solution is as follows：Sodium alginate is added to the water, 60 DEG C of water-baths are stirred
It mixes 2 hours, obtains sodium alginate aqueous solution；Wherein, the mass volume ratio of sodium alginate and water is 3g：80mL.
In step (4), the preparation method of carboxymethyl chitosan sugar aqueous solution is as follows：Carboxymethyl chitosan is soluble in water, system
At carboxymethyl chitosan sugar aqueous solution；Wherein, the mass volume ratio of carboxymethyl chitosan and water is 1g：70mL.
In step (4), the mass body of contained sodium alginate and glacial acetic acid, glutaraldehyde, emulsion in sodium alginate aqueous solution
Product is than being 3g：50mL：60mL：20mL.
In step (5), cured process conditions are：20 DEG C are handled 80 minutes, are then handled 5 minutes under condition of ice bath.
Utilize a kind of eye ointment for improvement eyesight that above-mentioned preparation method obtains.
Embodiment 2：
A kind of preparation method for the eye ointment improving eyesight, specific step is as follows：
(1) taurine and sialic acid are scattered in the water of aqueous emulsifier phase, obtain water phase；
(2) the deficient essential oil of fiber crops and evening primrose oil are scattered in the saturation Triglyceride DDD containing oil phase emulsifier, obtain oily phase；
(3) by water phase with oily mutually with mass ratio 1：0.3 mixing, high-pressure homogeneous processing obtain emulsion；
(4) glacial acetic acid is added into sodium alginate aqueous solution, carboxymethyl chitosan sugar aqueous solution and step (3) are added after stirring evenly
Gained emulsion, stirs evenly, and is subsequently added into glutaraldehyde, stirs 14 hours；
(5) solidify to get.
Wherein, in step (1), taurine, sialic acid, aqueous emulsifier phase and water mass ratio be 1：0.3：2：110.
In step (1), aqueous emulsifier phase is the mixture of PLURONICS F87, Tween 80, and three's mass ratio is 1：0.3.
In step (2), the mass ratio that fiber crops owe essential oil, evening primrose oil, oil phase emulsifier and saturation Triglyceride DDD is 1：
0.8：2：110.
In step (2), oil phase emulsifier is sorbester p17.
In step (2), the deficient essential oil of fiber crops is prepared by the following method to obtain：The deficient plant of fresh fiber crops is taken, it is dry, later at 65 DEG C
It is impregnated in warm water 150 minutes, then ultrasonic echography is handled 60 minutes, is heated to boiling, and is extracted 3 hours, is extracted, waved with ether
Dry diethyl ether to obtain the final product.
In step (3), the process conditions of high-pressure homogeneous processing are：50MPa, 15 circulations.
In step (4), the preparation method of sodium alginate aqueous solution is as follows：Sodium alginate is added to the water, 70 DEG C of water-baths are stirred
It mixes 3 hours, obtains sodium alginate aqueous solution；Wherein, the mass volume ratio of sodium alginate and water is 3g：80mL.
In step (4), the preparation method of carboxymethyl chitosan sugar aqueous solution is as follows：Carboxymethyl chitosan is soluble in water, system
At carboxymethyl chitosan sugar aqueous solution；Wherein, the mass volume ratio of carboxymethyl chitosan and water is 1g：70mL.
In step (4), the mass body of contained sodium alginate and glacial acetic acid, glutaraldehyde, emulsion in sodium alginate aqueous solution
Product is than being 3g：50mL：60mL：30mL.
In step (5), cured process conditions are：30 DEG C are handled 100 minutes, and 10 points are then handled under condition of ice bath
Clock.
Utilize a kind of eye ointment for improvement eyesight that above-mentioned preparation method obtains.
Embodiment 3：
A kind of preparation method for the eye ointment improving eyesight, specific step is as follows：
(1) taurine and sialic acid are scattered in the water of aqueous emulsifier phase, obtain water phase；
(2) the deficient essential oil of fiber crops and evening primrose oil are scattered in the saturation Triglyceride DDD containing oil phase emulsifier, obtain oily phase；
(3) by water phase with oily mutually with mass ratio 1：0.25 mixing, high-pressure homogeneous processing obtain emulsion；
(4) glacial acetic acid is added into sodium alginate aqueous solution, carboxymethyl chitosan sugar aqueous solution and step (3) are added after stirring evenly
Gained emulsion, stirs evenly, and is subsequently added into glutaraldehyde, stirs 13 hours；
(5) solidify to get.
Wherein, in step (1), taurine, sialic acid, aqueous emulsifier phase and water mass ratio be 1：0.25：1.5：105.
In step (1), aqueous emulsifier phase is the mixture of PLURONICS F87, Tween 80 and sodium taurocholate, and three's mass ratio is
1：0.25：0.35.
In step (2), the mass ratio that fiber crops owe essential oil, evening primrose oil, oil phase emulsifier and saturation Triglyceride DDD is 1：
0.6：1.5：105.
In step (2), oil phase emulsifier is the mixture of egg yolk lecithin and sorbester p17, and the two mass ratio is 1：1.3.
In step (2), the deficient essential oil of fiber crops is prepared by the following method to obtain：The deficient plant of fresh fiber crops is taken, it is dry, later at 55 DEG C
It is impregnated in warm water 100 minutes, then ultrasonic echography is handled 40 minutes, is heated to boiling, and is extracted 3 hours, is extracted, waved with ether
Dry diethyl ether to obtain the final product.
In step (3), the process conditions of high-pressure homogeneous processing are：40MPa, 12 circulations.
In step (4), the preparation method of sodium alginate aqueous solution is as follows：Sodium alginate is added to the water, 65 DEG C of water-baths are stirred
It mixes 3 hours, obtains sodium alginate aqueous solution；Wherein, the mass volume ratio of sodium alginate and water is 3g：80mL.
In step (4), the preparation method of carboxymethyl chitosan sugar aqueous solution is as follows：Carboxymethyl chitosan is soluble in water, system
At carboxymethyl chitosan sugar aqueous solution；Wherein, the mass volume ratio of carboxymethyl chitosan and water is 1g：70mL.
In step (4), the mass body of contained sodium alginate and glacial acetic acid, glutaraldehyde, emulsion in sodium alginate aqueous solution
Product is than being 3g：50mL：60mL：25mL.
In step (5), cured process conditions are：25 DEG C are handled 90 minutes, are then handled 8 minutes under condition of ice bath.
Utilize a kind of eye ointment for improvement eyesight that above-mentioned preparation method obtains.
Comparative example 1
A kind of preparation method of eye ointment, specific step is as follows：
(1) taurine is scattered in the water of aqueous emulsifier phase, obtains water phase；
(2) the deficient essential oil of fiber crops and evening primrose oil are scattered in the saturation Triglyceride DDD containing oil phase emulsifier, obtain oily phase；
(3) by water phase with oily mutually with mass ratio 1：0.2 mixing, high-pressure homogeneous processing obtain emulsion；
(4) glacial acetic acid is added into sodium alginate aqueous solution, carboxymethyl chitosan sugar aqueous solution and step (3) are added after stirring evenly
Gained emulsion, stirs evenly, and is subsequently added into glutaraldehyde, stirs 12 hours；
(5) solidify to get.
Wherein, in step (1), the mass ratio of taurine, aqueous emulsifier phase and water is 1：1：100.
In step (1), aqueous emulsifier phase is PLURONICS F87.
In step (2), the mass ratio that fiber crops owe essential oil, evening primrose oil, oil phase emulsifier and saturation Triglyceride DDD is 1：
0.5：1：100.
In step (2), oil phase emulsifier is egg yolk lecithin.
In step (2), the deficient essential oil of fiber crops is prepared by the following method to obtain：The deficient plant of fresh fiber crops is taken, it is dry, later at 45 DEG C
It is impregnated in warm water 60 minutes, then ultrasonic echography is handled 30 minutes, is heated to boiling, and is extracted 2 hours, is extracted, waved with ether
Dry diethyl ether to obtain the final product.
In step (3), the process conditions of high-pressure homogeneous processing are：30MPa, 10 circulations.
In step (4), the preparation method of sodium alginate aqueous solution is as follows：Sodium alginate is added to the water, 60 DEG C of water-baths are stirred
It mixes 2 hours, obtains sodium alginate aqueous solution；Wherein, the mass volume ratio of sodium alginate and water is 3g：80mL.
In step (4), the preparation method of carboxymethyl chitosan sugar aqueous solution is as follows：Carboxymethyl chitosan is soluble in water, system
At carboxymethyl chitosan sugar aqueous solution；Wherein, the mass volume ratio of carboxymethyl chitosan and water is 1g：70mL.
In step (4), the mass body of contained sodium alginate and glacial acetic acid, glutaraldehyde, emulsion in sodium alginate aqueous solution
Product is than being 3g：50mL：60mL：20mL.
In step (5), cured process conditions are：20 DEG C are handled 80 minutes, are then handled 5 minutes under condition of ice bath.
A kind of eye ointment obtained using above-mentioned preparation method.
Comparative example 2
A kind of preparation method of eye ointment, specific step is as follows：
(1) taurine and sialic acid are scattered in the water of aqueous emulsifier phase, obtain water phase；
(2) the deficient essential oil dispersion of fiber crops obtains oily phase in the saturation Triglyceride DDD containing oil phase emulsifier；
(3) by water phase with oily mutually with mass ratio 1：0.2 mixing, high-pressure homogeneous processing obtain emulsion；
(4) glacial acetic acid is added into sodium alginate aqueous solution, carboxymethyl chitosan sugar aqueous solution and step (3) are added after stirring evenly
Gained emulsion, stirs evenly, and is subsequently added into glutaraldehyde, stirs 12 hours；
(5) solidify to get.
Wherein, in step (1), taurine, sialic acid, aqueous emulsifier phase and water mass ratio be 1：0.2：1：100.
In step (1), aqueous emulsifier phase is PLURONICS F87.
In step (2), the mass ratio of the deficient essential oil of fiber crops, oil phase emulsifier and saturation Triglyceride DDD is 1：1：100.
In step (2), oil phase emulsifier is egg yolk lecithin.
In step (2), the deficient essential oil of fiber crops is prepared by the following method to obtain：The deficient plant of fresh fiber crops is taken, it is dry, later at 45 DEG C
It is impregnated in warm water 60 minutes, then ultrasonic echography is handled 30 minutes, is heated to boiling, and is extracted 2 hours, is extracted, waved with ether
Dry diethyl ether to obtain the final product.
In step (3), the process conditions of high-pressure homogeneous processing are：30MPa, 10 circulations.
In step (4), the preparation method of sodium alginate aqueous solution is as follows：Sodium alginate is added to the water, 60 DEG C of water-baths are stirred
It mixes 2 hours, obtains sodium alginate aqueous solution；Wherein, the mass volume ratio of sodium alginate and water is 3g：80mL.
In step (4), the preparation method of carboxymethyl chitosan sugar aqueous solution is as follows：Carboxymethyl chitosan is soluble in water, system
At carboxymethyl chitosan sugar aqueous solution；Wherein, the mass volume ratio of carboxymethyl chitosan and water is 1g：70mL.
In step (4), the mass body of contained sodium alginate and glacial acetic acid, glutaraldehyde, emulsion in sodium alginate aqueous solution
Product is than being 3g：50mL：60mL：20mL.
In step (5), cured process conditions are：20 DEG C are handled 80 minutes, are then handled 5 minutes under condition of ice bath.
A kind of eye ointment obtained using above-mentioned preparation method.
Test example
1, study on the stability
Eye ointment obtained by Examples 1 to 3 is dispensed after sterilizing in ultraviolet light 2 hours, sealing is placed in 25 DEG C of room temperature respectively
Lower progress room temperature long term test is investigated appearance, the sterile and centrifugal test (300r/ minutes) of eye ointment after 12 months, is as a result seen
Table 1.
1. study on the stability of table
| Appearance | It is sterile | Centrifugal test | |
| Embodiment 1 | Lotion uniform color has no variation | It is qualified | Without layering |
| Embodiment 2 | Lotion uniform color has no variation | It is qualified | Without layering |
| Embodiment 3 | Lotion uniform color has no variation | It is qualified | Without layering |
As shown in Table 1, eye ointment product of the invention is with good stability.
2, animal experiment
50 healthy large ear rabbits, 2.0 ± 0.2kg of weight are randomly divided into 5 groups, every group 10, are with intensity
The light of 4000liux irradiates, and light application time is 5 days, then carries out fatigue index marking to every lagophthalmos.Respectively using implementation
The eye ointment of example 1~3 and comparative example 1~2, daily early morning, each dosage 0.01g was used continuously 1~8 day with 1 time, saw daily
The variation of lagophthalmos items fatigue index is examined, and is given a mark and is recorded.Recurrence after being investigated one month after stopping using, knot
Fruit is shown in Table 2.
2. animal test results of table
As shown in Table 2, there is the eye ointment of Examples 1 to 3 obvious preferably anti-asthenopia effect, comparative example 1 to omit saliva
Liquid acid, comparative example 2 omit evening primrose oil, and antifatigue effect is poor.
3, clinical test
Juvenile shortsightedness patient 500 are chosen, the age is 12~16 years old, is randomly divided into 5 groups, uses embodiment 1 respectively
~3 or comparative example 1~2 eye ointment, each dosage 0.2g, daily early morning uses, is used continuously one month, investigates before treatment and controls
Vision condition after treatment.
It is tested eyesight using standard logarithmic visual acuity chart, eye is surveyed eyesight and is responsible for by same professional, and controlling for patient is evaluated
Therapeutic effect is divided into healing, effective and three kinds invalid, wherein cures：Eyesight >=5.0 after correction of refractive errors, asthenopia symptom
It disappears；It is effective：It corrects defects of vision and is not achieved 5.0, but two row of eyesight and two rows or more can be improved；In vain：Nothing mentions eyesight before and after treatment
It is high.It the results are shown in Table 3.
3. clinical therapeutic efficacy of table
| Cure rate (%) | Obvious effective rate (%) | Inefficiency (%) | |
| Embodiment 1 | 99 | 1 | 0 |
| Embodiment 2 | 99 | 1 | 0 |
| Embodiment 3 | 100 | 0 | 0 |
| Comparative example 1 | 40 | 38 | 22 |
| Comparative example 2 | 36 | 45 | 19 |
As shown in Table 3, the eye ointment of Examples 1 to 3 has preferable cure rate to myopia, and comparative example 1 omits sialic acid, right
Ratio 2 omits evening primrose oil, is obviously deteriorated to eyesight improving degree.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of preparation method for the eye ointment for improving eyesight, which is characterized in that specific step is as follows：
(1) taurine and sialic acid are scattered in the water of aqueous emulsifier phase, obtain water phase；
(2) the deficient essential oil of fiber crops and evening primrose oil are scattered in the saturation Triglyceride DDD containing oil phase emulsifier, obtain oily phase；
(3) by water phase with oily mutually with mass ratio 1：0.2~0.3 mixing, high-pressure homogeneous processing obtain emulsion；
(4) glacial acetic acid is added into sodium alginate aqueous solution, is added obtained by carboxymethyl chitosan sugar aqueous solution and step (3) after stirring evenly
Emulsion stirs evenly, and is subsequently added into glutaraldehyde, stirs 12~14 hours；
(5) solidify to get.
2. preparation method according to claim 1, which is characterized in that in step (1), taurine, sialic acid, water phase emulsification
The mass ratio of agent and water is 1：0.2~0.3：1~2：100~110.
3. preparation method according to claim 1, which is characterized in that in step (1), the aqueous emulsifier phase is that pool Lip river is husky
The mixture of nurse 188, Tween 80 and sodium taurocholate, three's mass ratio are 1：0.2~0.3：0.3~0.4.
4. preparation method according to claim 1, which is characterized in that in step (2), the deficient essential oil of fiber crops, evening primrose oil, oily phase
The mass ratio of emulsifier and saturation Triglyceride DDD is 1：0.5~0.8：1~2：100~110.
5. preparation method according to claim 1, which is characterized in that in step (2), the oil phase emulsifier is yolk ovum
The mixture of phosphatide and sorbester p17, the two mass ratio are 1：1.2~1.5.
6. preparation method according to claim 1, which is characterized in that in step (2), the deficient essential oil of fiber crops is made by the following method
It is standby to obtain：The fresh deficient plant of fiber crops is taken, it is dry, impregnate 60~150 minutes in 45~65 DEG C of warm water later, then ultrasonic echography
Processing 30~60 minutes, is heated to boiling, and extracts 2~3 hours, is extracted with ether, volatilize ether to obtain the final product.
7. preparation method according to claim 1, which is characterized in that in step (3), the process conditions of high-pressure homogeneous processing
For：30~50MPa, 10~15 circulations.
8. preparation method according to claim 1, which is characterized in that in step (4), contained sea in sodium alginate aqueous solution
The mass volume ratio of mosanom and glacial acetic acid, glutaraldehyde, emulsion is 3g：50mL：60mL：20~30mL.
9. preparation method according to claim 1, which is characterized in that in step (5), cured process conditions are：20~
30 DEG C are handled 80~100 minutes, are then handled 5~10 minutes under condition of ice bath.
10. utilizing a kind of eye ointment for improvement eyesight that preparation method described in any one of claim 1~9 obtains.
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| CN111035581A (en) * | 2019-12-31 | 2020-04-21 | 嘉必优生物技术（武汉）股份有限公司 | Method for maintaining stability of sialic acid solution at high temperature and application thereof |
| CN111450179A (en) * | 2019-01-18 | 2020-07-28 | 任玉娟 | Eyesight improving and eye protecting composition and application and preparation method thereof |
| CN116440069A (en) * | 2023-06-14 | 2023-07-18 | 中山大学附属第五医院 | Lubrication anesthesia antibacterial eye ointment and preparation method and application thereof |
| CN117122044A (en) * | 2023-08-25 | 2023-11-28 | 合肥工业大学 | Double gel and preparation method and application thereof |
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| CN111450179A (en) * | 2019-01-18 | 2020-07-28 | 任玉娟 | Eyesight improving and eye protecting composition and application and preparation method thereof |
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| CN116440069A (en) * | 2023-06-14 | 2023-07-18 | 中山大学附属第五医院 | Lubrication anesthesia antibacterial eye ointment and preparation method and application thereof |
| CN117122044A (en) * | 2023-08-25 | 2023-11-28 | 合肥工业大学 | Double gel and preparation method and application thereof |
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