CN111450179A - Eyesight improving and eye protecting composition and application and preparation method thereof - Google Patents
Eyesight improving and eye protecting composition and application and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an eyesight improving and eye protecting composition, and application and a preparation method thereof. The eyesight improving and eye protecting composition is prepared from wild chrysanthemum flower, glossy privet fruit, cassia seed, pipewort, mulberry leaf, dandelion, borneol, pearl powder and menthol. The eyesight improving and eye protecting composition is safe and reliable, can remarkably relieve the symptoms of visual fatigue, dry eyes, conjunctival congestion, blurred vision and the like caused by long-time use of eyes by adults, improves the skin around the eyes, recovers the vitality of the eyes, and achieves the effects of tonifying liver and kidney, clearing heat and purging fire, and replenishing vital essence to improve eyesight.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to an eyesight improving and eye protecting composition, and application and a preparation method thereof.
Background
The asthenopia is also called asthenopia, which is the asthenopia caused by overuse of eyes when working or learning at close distance, mainly takes blurred vision, intolerance of long-term vision, dry and uncomfortable eyes, acid swelling and lacrimation, headache and dizziness and the like as clinical manifestations, is a syndrome based on subjective symptoms of eyes, and interweaving of eye or general factors and mental (psychological) factors, has complex and various causes, is related to factors such as spirit, psychology, environment, personal constitution, diet and life style, and is the result of the combined action of various factors. In recent years, video terminals such as computers and smart phones are widely popularized, the incidence rate of visual fatigue tends to rise gradually, negative emotions such as physiological fatigue, pain and anxiety, dysphoria and insomnia caused by physiological fatigue and pain of patients seriously affect the work and study of the patients, and the life quality of the patients is reduced. The asthenopia is characterized by subjective symptoms, aggravated after eye use, and relieved or disappeared after rest.
Western medicine considers the etiology of asthenopia including the following aspects: eye-related diseases (conjunctivitis, xerophthalmia, blepharitis, keratitis, cataract, etc.), ametropia, accommodation and convergence dysfunction, extraocular muscle dysfunction, systemic diseases, psychogenic and environmental factors, etc., and most western medicines adopt the treatment of causes, such as ametropia by wearing glasses; surgical methods correct for astigmatism; extraocular muscle training or chemotherapy, etc. The traditional Chinese medicine classifies the asthenopia into the category of liver fatigue, the modern traditional Chinese medicine generally considers that the incidence of the asthenopia is mainly based on liver-kidney yin deficiency, spleen-stomach weakness, qi stagnation and blood stasis, and excessive use of eyes and mental strain are the causes of the incidence; deficiency of liver and kidney, loss of essence and blood and failure to nourish the spleen; spleen deficiency and qi deficiency failing to nourish the eyes; exhaustion of the eyes to look at it and consumption of essence and blood, deficiency of heart and blood; liver qi stagnation can nourish eyes, resulting in asthenopia. Traditional Chinese medicine focuses on whole-body adjustment, rest and maintenance, and prevents, relieves and treats asthenopia and related symptoms by dialectical treatment aiming at specific etiology and pathogenesis and conditioning measures for 'treating diseases', but the curative effects of medicines adopted by patients of different ages are different.
Disclosure of Invention
The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, the invention aims to provide the eyesight improving and eye protecting composition, and the application and the preparation method thereof. The eyesight improving and eye protecting composition is safe and reliable, can remarkably relieve the symptoms of visual fatigue, dry eyes, conjunctival congestion, blurred vision and the like caused by long-time use of eyes by adults, improves the skin around the eyes, recovers the vitality of the eyes, and achieves the effects of tonifying liver and kidney, clearing heat and purging fire, and replenishing vital essence to improve eyesight.
In accordance with a first aspect of the present invention, there is provided a visual and eye-protecting composition. According to the embodiment of the invention, the raw materials of the eyesight and eye protection composition comprise wild chrysanthemum flower, glossy privet fruit, cassia seed, pipewort, mulberry leaf, dandelion, borneol, pearl powder and menthol. According to the eyesight-improving and eye-protecting composition provided by the embodiment of the invention, the wild chrysanthemum flower, the dandelion, the mulberry leaf and the pipewort have the effects of dispelling wind and heat, clearing liver, improving eyesight and removing nebula, the glossy privet fruit and the cassia seed have the effects of nourishing liver and kidney, clearing heat and improving eyesight, the borneol and the menthol have the effects of dispelling wind and heat, clearing heat and benefiting head and eyes, the pearl powder has the effects of calming nerves and arresting convulsion, and improving eyesight and removing nebula.
In addition, the eyesight-improving eye-protecting composition according to the above embodiment of the present invention may also have the following additional technical features:
in some embodiments of the present invention, in the raw materials, a mass ratio of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf, the dandelion, the borneol, the pearl powder and the menthol is 10-100: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 5-50 parts of: 5-50 parts. Therefore, the effects of tonifying liver and kidney, clearing heat and purging fire, and replenishing vital essence to improve eyesight of the eyesight improving and eye protecting composition can be remarkably improved.
In some embodiments of the present invention, in the raw materials, a mass ratio of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf, the dandelion, the borneol, the pearl powder and the menthol is 65-85 parts: 40-60 parts of: 65-85 parts of: 40-60 parts of: 40-60 parts of: 40-60 parts of: 50-80 parts of: 25-40 parts of: 26-42 parts. Therefore, the effects of tonifying liver and kidney, clearing heat and purging fire, and replenishing vital essence to improve eyesight of the eyesight improving and protecting composition can be further improved.
In some embodiments of the present invention, in the raw materials, a mass ratio of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf, the dandelion, the borneol, the pearl powder and the menthol is 75: 50 parts of: 75 parts of: 50 parts of: 50 parts of: 50 parts of: 66 parts of: 33 parts of: 33 parts of. Therefore, the effects of tonifying liver and kidney, clearing heat and purging fire, and benefiting essence and improving eyesight of the eyesight improving and protecting composition can be further improved.
In some embodiments of the present invention, the eyesight improving and eye protecting composition is prepared by mixing water-decocted extracts of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion with the borneol, the pearl powder, the menthol and pharmaceutical excipients.
In some embodiments of the present invention, the eyesight protection composition is prepared by the steps of: (1) mixing the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion, and then decocting and extracting the mixture by water to obtain an extracting solution; (2) mixing the borneol fine powder and the pearl powder with the extracting solution in the step (1) to obtain a mixed solution; (3) heating and melting glycerol, propylene glycol, polyoxyl (40) stearate and potassium sorbate to obtain a water phase; (4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution; (5) heating and melting glyceryl monostearate, cetyl alcohol, light liquid paraffin and medium-chain fatty acid triglyceride to obtain oil phase; (6) mixing the menthol with the oil phase obtained in the step (5) so as to obtain an oil phase mixed solution; (7) and mixing and emulsifying the water phase mixed solution and the oil phase mixed solution to obtain the eyesight improving and eye protecting composition. Therefore, the eyesight-improving and eye-protecting composition can be effectively prepared.
In some embodiments of the invention, the eyesight-improving and eye-protecting composition is an external preparation.
In some embodiments of the present invention, the external preparation is an ointment, a cream, a gel or a patch. Therefore, the eye mask can be applied or smeared around eyes for use.
In some embodiments of the present invention, the external preparation is a cream.
According to a second aspect of the invention, the invention provides the use of the above eyesight-improving eye-protecting composition for improving eyesight and protecting eyes of adults. According to the embodiment of the invention, the eyesight improving and eye protecting composition is applied to the periphery of eyes of adults, so that the symptoms of visual fatigue, dry eyes, conjunctival congestion, blurred vision and the like caused by long-time use of eyes of the adults can be remarkably relieved, the skin around the eyes can be improved, the vitality of the eyes can be recovered, and the effects of tonifying liver and kidney, clearing heat and purging fire, and benefiting essence and improving eyesight can be achieved.
According to a third aspect of the invention, the invention provides a method for preparing the above-mentioned eyesight-improving and eye-protecting composition. According to the embodiment of the invention, the method is to mix the water-decocted extract of the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion with the borneol fine powder, the pearl powder, the menthol and the pharmaceutical excipients to prepare the eyesight-improving and eye-protecting composition. The method can be used for preparing the eyesight improving and eye protecting composition in required dosage form according to actual needs, and the prepared eyesight improving and eye protecting composition is safe and reliable, is particularly suitable for improving the asthenopia problem of adults, can remarkably relieve the symptoms of asthenopia, dry and astringent eyes, conjunctival congestion, blurred vision and the like caused by long-time use of eyes, improves the skin around the eyes, recovers the vitality of the eyes, and achieves the effects of tonifying liver and kidney, clearing heat and purging fire, replenishing vital essence and improving eyesight.
In some embodiments of the invention, the method of making an eyesight improving and eye protecting composition comprises the steps of: (1) mixing the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion, and then decocting and extracting the mixture by water to obtain an extracting solution; (2) mixing the borneol fine powder, the pearl powder and the extracting solution in the step (1) to obtain a mixed solution; (3) heating and melting glycerol, propylene glycol, polyoxyl (40) stearate and potassium sorbate to obtain a water phase; (4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution; (5) heating and melting glyceryl monostearate, cetyl alcohol, light liquid paraffin and medium-chain fatty acid triglyceride to obtain oil phase; (6) mixing the menthol with the oil phase obtained in the step (5) so as to obtain an oil phase mixed solution; (7) and mixing and emulsifying the water phase mixed solution and the oil phase mixed solution to obtain the eyesight improving and eye protecting composition. Therefore, the eyesight-improving and eye-protecting composition in the form of cream can be effectively prepared, and the absorption of the eyesight-improving and eye-protecting composition can be effectively promoted.
In some embodiments of the present invention, in step (1), the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion are mixed, decocted and extracted twice with water, and the decoction is sequentially filtered, concentrated and centrifuged to obtain the extract, wherein the extraction time is 0.5 to 1.5 hours each time. Therefore, the utilization rate of the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion can be obviously improved, and the preparation efficiency of the eyesight improving and eye protecting composition can be obviously improved.
In some embodiments of the invention, in the step (1), the mass ratio of the total mass of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion to water in each decocting extraction process with water is 1 (2-5); the concentration ratio of the decoction extraction is (5-10) to 1. Therefore, the effects of tonifying liver and kidney, clearing heat and purging fire, and replenishing vital essence to improve eyesight of the eyesight improving and eye protecting composition can be further improved.
In some embodiments of the present invention, in the step (3), based on 10 to 100 parts by weight of the borneol fine powder in the step (2) and 5 to 50 parts by weight of the pearl powder, the mass ratio of the glycerol, the propylene glycol, the polyoxyl (40) stearate and the potassium sorbate is 60 to 80 parts: 30-50 parts of: 20-30 parts of: 3-10 parts of a material, wherein the heating and melting temperature is 80-90 ℃. Therefore, the components can be fully mixed, a uniform water phase can be obtained, the evaporation of the water phase can be avoided, and the preparation efficiency can be further improved.
In some embodiments of the present invention, in the step (5), the ratio of the values of the glyceryl monostearate, the cetyl alcohol, the light liquid paraffin and the medium-chain fatty acid triglyceride is as follows, based on 5 to 50 parts by weight of the menthol: 60-80 parts of: 20-40 parts of: 40-60 parts of: 200 portions to 300 portions, and the temperature of the heating and melting is 80 to 90 ℃. Therefore, the components can be fully mixed to obtain a uniform oil phase, and the preparation efficiency can be further improved.
In some embodiments of the invention, in step (6), the mixing temperature is 80-90 degrees celsius. Therefore, the menthol can be fully dissolved in the oil phase, and the effects of clearing heat, purging pathogenic fire, replenishing vital essence and improving eyesight of the eyesight-improving eye-protecting composition can be further ensured.
In some embodiments of the present invention, in the step (7), the emulsification treatment is performed by stirring at 6000 and 7000r/min at a temperature of 80-90 ℃ for 15-20 minutes. Therefore, the efficiency and the effect of emulsification treatment can be further improved, the drug effect of the finally prepared eyesight-improving and eye-protecting composition can be ensured, the composition is more exquisite, uniform and stable, and the composition has better moisturizing and air permeability and antibacterial and antiseptic properties.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
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The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 is a flow diagram of a method for preparing a eyesight and eye-protecting composition according to one embodiment of the invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.
In accordance with a first aspect of the present invention, there is provided a visual and eye-protecting composition. According to the embodiment of the invention, the raw materials of the eyesight and eye protection composition comprise wild chrysanthemum flower, glossy privet fruit, cassia seed, pipewort, mulberry leaf, dandelion, borneol, pearl powder and menthol. According to the eyesight-improving and eye-protecting composition provided by the embodiment of the invention, the wild chrysanthemum flower, the dandelion, the mulberry leaf and the pipewort have the effects of dispelling wind and heat, clearing liver, improving eyesight and removing nebula, the glossy privet fruit and the cassia seed have the effects of nourishing liver and kidney, clearing heat and improving eyesight, the borneol and the menthol have the effects of dispelling wind and heat, clearing heat and benefiting head and eyes, the pearl powder has the effects of calming nerves and arresting convulsion, and improving eyesight and removing nebula.
The above-described embodiments of the present invention are described in detail below.
According to a specific embodiment of the invention, in the raw materials, the mass ratio of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf, the dandelion, the borneol, the pearl powder and the menthol can be 10-100 parts: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 5-50 parts of: 5-50 parts. The inventor finds that if the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion in the eyesight and eye protection composition are used in too small amount, the effect of relieving the eye fatigue is not obvious; if the content of borneol and menthol in the eyesight and eye protection composition is too much, the irritation to skin is larger, and if the content is too little, the effects of dispelling wind, dissipating heat and clearing head and eyes are not ideal; if the pearl powder content is less, the effect of calming the nerves and arresting convulsion is not obvious, and the preparation difficulty of the eyesight-improving and eye-protecting composition is increased due to excessive content, particularly the preparation difficulty when a paste dosage form is adopted, so that the stability and the uniformity of the paste eyesight-improving and eye-protecting composition are influenced, therefore, the synergistic effect of all the medicinal components can be further improved by controlling the mass ratio of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf, the dandelion, the borneol, the pearl powder and the menthol to be the above mass ratio, so that the effects of tonifying the liver and kidney, clearing heat and purging fire, benefiting essence and improving eyesight of the eyesight-improving and eye-protecting composition are remarkably improved, and the. Preferably, the mass ratio of the wild chrysanthemum flower to the glossy privet fruit to the cassia seed to the pipewort flower to the mulberry leaf to the dandelion to the borneol to the pearl powder to the menthol can be 65-85 parts: 40-60 parts of: 65-85 parts of: 40-60 parts of: 40-60 parts of: 40-60 parts of: 50-80 parts of: 25-40 parts of: 26-42 parts of the composition can further improve the effects of tonifying liver and kidney, clearing heat and purging fire, and replenishing vital essence to improve eyesight; more preferably, the mass ratio of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf, the dandelion, the borneol, the pearl powder and the menthol can be 75 parts: 50 parts of: 75 parts of: 50 parts of: 50 parts of: 50 parts of: 66 parts of: 33 parts of: 33 parts of the composition can further improve the effects of tonifying liver and kidney, clearing heat and purging fire, and replenishing vital essence to improve eyesight.
According to another embodiment of the present invention, the eyesight improving and eye protecting composition may be prepared by mixing water-decocted extracts of wild chrysanthemum flower, glossy privet fruit, cassia seed, pipewort, mulberry leaf and dandelion, with borneol, pearl powder, menthol and pharmaceutical excipients. Therefore, the active ingredients in the raw material components can be fully mixed, and the preparation of the external preparation can be further facilitated.
According to yet another embodiment of the present invention, the eyesight and eye protection composition may be prepared by the steps of: (1) mixing flos Chrysanthemi Indici, fructus Ligustri Lucidi, semen Cassiae, flos Eriocauli, folium Mori and herba Taraxaci, and decocting with water to obtain extractive solution; (2) mixing the borneol fine powder and the pearl powder with the extracting solution obtained in the step (1) to obtain a mixed solution; (3) heating and melting glycerol, propylene glycol, polyoxyl (40) stearate and potassium sorbate to obtain a water phase; (4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution; (5) heating and melting glyceryl monostearate, cetyl alcohol, light liquid paraffin and medium-chain fatty acid triglyceride to obtain oil phase; (6) mixing menthol with the oil phase obtained in the step (5) so as to obtain oil phase mixed liquor; (7) mixing the water phase mixed solution and the oil phase mixed solution, and emulsifying to obtain the eyesight improving and eye protecting composition. Therefore, the eyesight-improving and eye-protecting composition in a cream dosage form can be effectively prepared, and the effective components in the eyesight-improving and eye-protecting composition can be absorbed more easily.
According to another embodiment of the present invention, the eyesight improving and eye protecting composition may be an external preparation, for example, an ointment, a cream, a gel or a patch, so that the eyesight improving and eye protecting composition can be conveniently and rapidly applied by being applied or smeared around the eyes. Preferably, the external preparation may be a cream, thereby not only being more convenient to use, but also further promoting absorption of the effective ingredient in the eye-protecting composition.
According to a second aspect of the invention, the invention provides the use of the above eyesight-improving eye-protecting composition for improving eyesight and protecting eyes of adults. According to the embodiment of the invention, the eyesight improving and eye protecting composition is applied to the periphery of eyes of adults, so that the symptoms of visual fatigue, dry eyes, conjunctival congestion, blurred vision and the like caused by long-time use of eyes of the adults can be remarkably relieved, the skin around the eyes can be improved, the vitality of the eyes can be recovered, and the effects of tonifying liver and kidney, clearing heat and purging fire, and benefiting essence and improving eyesight can be achieved.
According to a third aspect of the invention, the invention provides a method for preparing the above-mentioned eyesight-improving and eye-protecting composition. According to the embodiment of the invention, the method is to mix the water-decocted extract of the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion with the borneol fine powder, the pearl powder, the menthol and the pharmaceutical excipients to prepare the eyesight-improving and eye-protecting composition. The method can be used for preparing the eyesight improving and eye protecting composition in required dosage form according to actual needs, and the prepared eyesight improving and eye protecting composition is safe and reliable, is particularly suitable for improving the asthenopia problem of adults, can remarkably relieve the symptoms of asthenopia, dry and astringent eyes, conjunctival congestion, blurred vision and the like caused by long-time use of eyes, improves the skin around the eyes, recovers the vitality of the eyes, and achieves the effects of tonifying liver and kidney, clearing heat and purging fire, replenishing vital essence and improving eyesight. It should be noted that the features and effects described above for the eyesight improving and eye protecting composition are also applicable to the method for preparing the eyesight improving and eye protecting composition, and are not described herein again, and in addition, the fine powder of borneol in the present invention refers to powdered borneol.
Further, as shown in fig. 1, the method for preparing the eyesight improving and eye protecting composition may comprise the following steps: (1) mixing flos Chrysanthemi Indici, fructus Ligustri Lucidi, semen Cassiae, flos Eriocauli, folium Mori and herba Taraxaci, and decocting with water to obtain extractive solution; (2) mixing the borneol fine powder and the pearl powder with the extracting solution in the step (1) to obtain a mixed solution; (3) heating and melting glycerol, propylene glycol, polyoxyl (40) stearate and potassium sorbate to obtain a water phase; (4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution; (5) heating and melting glyceryl monostearate, cetyl alcohol, light liquid paraffin and medium-chain fatty acid triglyceride to obtain oil phase; (6) mixing menthol with the oil phase obtained in the step (5) to obtain an oil phase mixed solution; (7) mixing the water phase mixed solution and the oil phase mixed solution, and emulsifying to obtain the eyesight improving and eye protecting composition. Therefore, the eyesight-improving and eye-protecting composition in the form of cream can be effectively prepared, and the absorption of the eyesight-improving and eye-protecting composition can be effectively promoted.
Further, in the step (1), the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion are mixed and then decocted and extracted twice by adding water, and the decoction is sequentially filtered, concentrated and centrifuged to obtain an extracting solution, wherein the extracting time can be 0.5-1.5 hours each time. Wherein, the mass ratio of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf, the dandelion, the borneol, the pearl powder and the menthol can be 10-100 parts: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 5-50 parts of: 5-50 parts, the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion are mixed and then extracted, so that the extraction efficiency can be obviously improved, the drug effect of the components cannot be influenced, and the extraction efficiency and the extraction effect can be further improved by controlling the extraction conditions, so that the utilization rate of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion and the efficiency of preparing the eyesight and eye protection composition are obviously improved; of course, the above-mentioned several drugs may be extracted, concentrated and mixed separately. Wherein before the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion are extracted, the pipewort, the mulberry leaf, the dandelion and the like can be crushed in advance, so that the extraction effect of the pipewort, the mulberry leaf, the dandelion and the like can be further improved.
Further, in the step (1), in each water-adding decoction extraction process, the mass ratio of the total mass of the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion to water can be 1 (2-5); the concentration ratio of decocting extraction can be (5-10): 1. According to the invention, by further controlling the water adding amount in the extraction process and the concentration ratio in the concentration process, the extraction effect and the utilization rate of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion can be further improved, the concentration of active ingredients in the extracting solution can be obviously improved, and the finally prepared eyesight improving and eye protecting composition has enough extract content, so that the effects of tonifying liver and kidney, clearing heat and purging fire and benefiting essence and improving eyesight are further improved.
Further, in the step (3), on the basis of 10-100 parts by weight of the borneol fine powder and 5-50 parts by weight of the pearl powder in the step (2), the mass ratio of the glycerol, the propylene glycol, the polyoxyl (40) stearate and the potassium sorbate is 60-80 parts: 30-50 parts of: 20-30 parts of: 3-10 parts, for example 65 parts: 45 parts of: 25 parts of: 4 parts and 70 parts: 40 parts of: 28 parts of: 6 parts and 75 parts: 35 parts of: 24 parts of: 8 or 78 parts: 32 parts of: 22 parts of: 9 parts, and the temperature for heating and melting is 80-90 ℃, for example, 82 ℃, 85 ℃ or 88 ℃. According to the invention, by controlling the mass ratio of the glycerol, the propylene glycol, the polyoxyl (40) stearate and the potassium sorbate, the components can be fully mixed to obtain a uniform water phase, and the prepared water phase is fully mixed with the extracting solution obtained in the step (1), so that the finally prepared eyesight-improving and eye-protecting composition is more exquisite and uniform and has better moisturizing performance and antibacterial and antiseptic properties, and the comprehensive effect of the eyesight-improving and eye-protecting composition is further improved; in addition, the evaporation of the water phase can be avoided and the preparation efficiency can be further improved by controlling the heating and melting conditions.
Further, in the step (5), the ratio of the values of the glyceryl monostearate, the cetyl alcohol, the light liquid paraffin and the medium-chain fatty acid triglyceride is as follows based on 5-50 parts by weight of the menthol: 60-80 parts of: 20-40 parts of: 40-60 parts of: 200-300 parts, for example, may be 75 parts: 25 parts of: 55 parts of: 250 parts and 70 parts: 30 parts of: 50 parts of: 275 parts and 65 parts: 35 parts of: 45 parts of: 225 parts or 60 parts: 40 parts of: 40 parts of: 280 parts, and the temperature for heating and melting is 80-90 ℃, for example, 83 ℃, 86 ℃ or 89 ℃, wherein the medium chain fatty acid triglyceride can be caprylic/capric triglyceride (GTCC). According to the invention, by controlling the mass ratio and the heating melting temperature of the glyceryl monostearate, the cetyl alcohol, the light liquid paraffin and the medium-chain fatty triglyceride, the components can be fully mixed to obtain a uniform oil phase, and the loss of the oil phase can be remarkably reduced; further, in the step (6), the mixing temperature of the menthol and the oil phase can be 80-90 ℃, so that the menthol can be fully dissolved in the oil phase, the loss of the oil phase can be reduced, and the effects of clearing heat, purging pathogenic fire, benefiting essence and improving eyesight of the eyesight-improving eye-protecting composition can be further ensured.
Further, in the step (7), the emulsification treatment is performed at 80-90 ℃ and at 6000-7000r/min for 15-20 minutes, for example, the emulsification treatment temperature can be 84 ℃, 85 ℃ or 86 ℃, the rotation speed can be 6200r/min, 6500r/min or 6800r/min, and the stirring time can be 15 minutes, 16 minutes or 18 minutes. According to the invention, by controlling the emulsification treatment conditions, the emulsification treatment efficiency and effect can be further improved, the drug effect of the finally prepared eyesight-improving and eye-protecting composition can be ensured, and the composition is more exquisite, uniform and stable, and has better moisture-preserving and air-permeable properties and antibacterial and antiseptic properties.
The invention will now be described with reference to specific examples, which are intended to be illustrative only and not to be limiting in any way.
Example 1
The eyesight improving and eye protecting composition comprises the following raw materials in parts by mass: 100 parts of: 10 parts of: 100 parts of: 10 parts of: 100 parts of: 10 parts of: 50 parts of: 5 parts of the raw materials.
The preparation method comprises the following steps:
(1) taking 10g of wild chrysanthemum, 100g of glossy privet fruit, 10g of cassia seed, 100g of pipewort, 10g of mulberry leaf and 100g of dandelion, mixing, adding water, decocting and extracting twice, filtering, concentrating and centrifuging decoction liquid in sequence to obtain extract, wherein the extraction time is 0.5 hour each time, in the process of decocting and extracting with water each time, the mass ratio of the total mass of the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion is 1:2, and the concentration ratio of the decoction and extraction is 10: 1;
(2) mixing 10g of borneol fine powder and 50g of pearl powder with the extracting solution obtained in the step (1);
(3) heating and melting 60g of glycerol, 50g of propylene glycol, 20g of polyoxyl (40) stearate and 10g of potassium sorbate at 90 ℃ to obtain a water phase;
(4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution;
(5) heating and melting 60g of glyceryl monostearate, 40g of cetyl alcohol, 40g of light liquid paraffin and 300g of medium-chain fatty acid triglyceride (GTCC) at 80 ℃ to obtain an oil phase;
(6) dissolving 5g of menthol in the oil phase obtained in the step (5) to obtain oil phase mixed solution;
(7) mixing the water phase mixed solution and the oil phase mixed solution, and emulsifying, wherein the emulsifying is to stir at the temperature of 90 ℃ and the rotating speed of 6000r/min for 20 minutes, continue stirring and cooling to about 40 ℃, and finally obtain the eyesight-improving and eye-protecting composition.
Example 2
The eyesight improving and eye protecting composition comprises 100 parts by mass of wild chrysanthemum flower, glossy privet fruit, cassia seed, pipewort, mulberry leaf, dandelion, borneol, pearl powder and menthol: 10 parts of: 100 parts of: 10 parts of: 100 parts of: 10 parts of: 100 parts of: 5 parts of: 50 parts of the raw materials.
The preparation method comprises the following steps:
(1) taking 100g of wild chrysanthemum, 10g of glossy privet fruit, 100g of cassia seed, 10g of pipewort, 100g of mulberry leaf and 10g of dandelion, mixing, adding water, decocting and extracting twice, filtering, concentrating and centrifuging decoction liquid in sequence to obtain extract, wherein the extraction time is 1.5 hours each time, in the process of decocting and extracting with water each time, the mass ratio of the total mass of the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion is 1:5, and the concentration ratio of the decoction and extraction is 5: 1;
(2) mixing 100g of borneol fine powder and 5g of pearl powder with the extracting solution obtained in the step (1);
(3) heating and melting 80g of glycerol, 30g of propylene glycol, 30g of polyoxyl (40) stearate and 3g of potassium sorbate at 80 ℃ to obtain a water phase;
(4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution;
(5) heating and melting 80g of glyceryl monostearate, 20g of cetyl alcohol, 60g of light liquid paraffin and 200g of medium-chain fatty acid triglyceride (GTCC) at 90 ℃ to obtain an oil phase;
(6) dissolving 50g of menthol in the oil phase obtained in the step (5) to obtain oil phase mixed solution;
(7) mixing the water phase mixed solution and the oil phase mixed solution, and performing emulsification treatment, wherein the emulsification treatment is to stir at the temperature of 80 ℃ and the rotating speed of 7000r/min for 15 minutes, continue stirring and cool to about 40 ℃, and finally obtain the eyesight-improving and eye-protecting composition.
Example 3
The eyesight improving and eye protecting composition comprises 65 parts by mass of wild chrysanthemum flower, glossy privet fruit, cassia seed, pipewort, mulberry leaf, dandelion, borneol, pearl powder and menthol: 60 parts of: 65 parts of: 60 parts of: 40 parts of: 60 parts of: 50 parts of: 40 parts of: 26 parts of (A).
The preparation method comprises the following steps:
(1) taking 65g of wild chrysanthemum, 60g of glossy privet fruit, 65g of cassia seed, 60g of pipewort, 40g of mulberry leaf and 60g of dandelion, mixing, adding water, decocting and extracting twice, filtering, concentrating and centrifuging decoction liquid in sequence to obtain extract, wherein the extraction time is 1 hour each time, in the process of decocting and extracting with water each time, the mass ratio of the total mass of the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion is 1:2.5, and the concentration ratio of the decoction and extraction is 7.5: 1;
(2) mixing 50g of borneol fine powder and 40g of pearl powder with the extracting solution obtained in the step (1);
(3) heating and melting 70g of glycerol, 40g of propylene glycol, 25g of polyoxyl (40) stearate and 6.5g of potassium sorbate at 85 ℃ to obtain a water phase;
(4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution;
(5) heating and melting 70g of glyceryl monostearate, 30g of cetyl alcohol, 50g of light liquid paraffin and 250g of medium-chain fatty acid triglyceride (GTCC) at 85 ℃ to obtain an oil phase;
(6) dissolving 26g of menthol in the oil phase obtained in the step (5) to obtain oil phase mixed solution;
(7) and mixing and emulsifying the water phase mixed solution and the oil phase mixed solution, wherein the emulsifying treatment is to stir for 17 minutes at the rotating speed of 6500r/min at the temperature of 85 ℃, and continue stirring and cooling to about 40 ℃ to finally obtain the eyesight-improving and eye-protecting composition.
Example 4
The eyesight improving and eye protecting composition comprises 75 parts by mass of wild chrysanthemum flower, glossy privet fruit, cassia seed, pipewort, mulberry leaf, dandelion, borneol, pearl powder and menthol: 50 parts of: 75 parts of: 50 parts of: 50 parts of: 50 parts of: 66 parts of: 33 parts of: 33 parts of.
The preparation method comprises the following steps:
(1) taking 75g of wild chrysanthemum, 50g of glossy privet fruit, 75g of cassia seed, 50g of pipewort, 50g of mulberry leaf and 50g of dandelion, mixing, adding water, decocting and extracting twice, filtering, concentrating and centrifuging decoction liquid in sequence to obtain extract, wherein the extraction time is 1 hour each time, in the process of decocting and extracting with water each time, the mass ratio of the total mass of the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion is 1:3, and the concentration ratio of the decoction and extraction is 6: 1;
(2) mixing 66g of borneol fine powder and 33g of pearl powder with the extracting solution obtained in the step (1);
(3) heating and melting 75g of glycerol, 35g of propylene glycol, 28g of polyoxyl (40) stearate and 5g of potassium sorbate at 85 ℃ to obtain a water phase;
(4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution;
(5) heating and melting 65g of glyceryl monostearate, 35g of cetyl alcohol, 45g of light liquid paraffin and 275g of medium-chain fatty acid triglyceride (GTCC) at 85 ℃ to obtain an oil phase;
(6) dissolving 33g of menthol in the oil phase obtained in the step (5) to obtain oil phase mixed solution;
(7) mixing the water phase mixed solution and the oil phase mixed solution, and emulsifying, wherein the emulsifying treatment is to stir at the rotating speed of 6800r/min for 16 minutes at the temperature of 85 ℃, and continuously stir and cool to about 40 ℃ to finally obtain the eyesight-improving and eye-protecting composition.
Example 5
The eyesight improving and eye protecting composition comprises 85 parts by mass of wild chrysanthemum flower, glossy privet fruit, cassia seed, pipewort, mulberry leaf, dandelion, borneol, pearl powder and menthol: 40 parts of: 85 parts of: 40 parts of: 60 parts of: 40 parts of: 80 parts of: 25 parts of: 42 parts of the raw materials.
The preparation method comprises the following steps:
(1) taking 85g of wild chrysanthemum, 40g of glossy privet fruit, 85g of cassia seed, 40g of pipewort, 60g of mulberry leaf and 40g of dandelion, mixing, adding water, decocting and extracting twice, filtering, concentrating and centrifuging decoction liquid in sequence to obtain extract, wherein the extraction time is 1 hour each time, in the process of decocting and extracting with water each time, the mass ratio of the total mass of the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion is 1:2, and the concentration ratio of the decocting and extracting is 9: 1;
(2) mixing 80g of borneol fine powder and 25g of pearl powder with the extracting solution obtained in the step (1);
(3) heating and melting 65g of glycerol, 45g of propylene glycol, 24g of polyoxyl (40) stearate and 8g of potassium sorbate at 85 ℃ to obtain a water phase;
(4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution;
(5) heating and melting 75g of glyceryl monostearate, 25g of cetyl alcohol, 55g of light liquid paraffin and 225g of medium-chain fatty acid triglyceride (GTCC) at 85 ℃ to obtain an oil phase;
(6) dissolving 42g of menthol in the oil phase obtained in the step (5) to obtain oil phase mixed solution;
(7) mixing the water phase mixed solution and the oil phase mixed solution, and emulsifying, wherein the emulsifying treatment is to stir at the temperature of 85 ℃ and the rotating speed of 6500r/min for 18 minutes, continue stirring and cooling to about 40 ℃, and finally obtain the eyesight-improving and eye-protecting composition.
Evaluation:
the eyesight-improving and eye-protecting composition is evaluated, and the evaluation method and the evaluation standard are as follows:
the evaluation method comprises the following steps: aiming at the visual fatigue problems such as visual fatigue, dry eye, conjunctival congestion, blurred vision and the like caused by long-term use of eyes by adults, the eyesight-improving and eye-protecting composition prepared in the embodiment 4 is used by volunteers, the using effect is determined by scoring, the score is 0-10, the score is 0 without fatigue relieving effect, the fatigue relieving effect is not significant under 5, the fatigue relieving effect is significant under 5 and above 5, the fatigue relieving effect is complete under 10, the volunteers score after each use, and the average given score of each volunteer is counted; and asking the composition of the present invention for irritancy and adverse reactions. Wherein the number of volunteers is 500, the age is not less than 18 years old, the using time is five months, and the medicine is only used when the asthenopia problem appears. The evaluation of volunteers (456) who had been used 15 times or more was counted, and 8 volunteers reported that they had slight eye discomfort and were discontinued after use and had no other adverse reactions after discontinuation. The evaluation result statistics show that the average score of all 456 volunteers is 8.0 points, wherein the average score of 44 volunteers is less than 5 points, and the average score of 412 volunteers is 5 points or more, which indicates that the composition has a good asthenopia relieving effect on adults.
From the above, the eyesight improving and eye protecting composition is safe and reliable, has no irritation to eyes, can remarkably relieve the symptoms of visual fatigue, dry eyes, conjunctival congestion, blurred vision and the like caused by long-time use of eyes by adults, and has the effects of tonifying liver and kidney, clearing heat and purging fire, and replenishing vital essence to improve eyesight.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.
Claims (10)
1. The eyesight improving and eye protecting composition is characterized in that raw materials of the eyesight improving and eye protecting composition comprise wild chrysanthemum flower, glossy privet fruit, cassia seed, pipewort, mulberry leaf, dandelion, borneol, pearl powder and menthol.
2. The composition for improving eyesight and protecting eyes according to claim 1, wherein the raw materials comprise the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf, the dandelion, the borneol, the pearl powder and the menthol in a mass ratio of 10-100 parts: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 10-100 parts of: 5-50 parts of: 5-50 parts;
preferably, in the raw materials, the mass ratio of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf, the dandelion, the borneol, the pearl powder and the menthol is 65-85 parts: 40-60 parts of: 65-85 parts of: 40-60 parts of: 40-60 parts of: 40-60 parts of: 50-80 parts of: 25-40 parts of: 26-42 parts;
more preferably, in the raw materials, the mass ratio of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf, the dandelion, the borneol, the pearl powder and the menthol is 75: 50 parts of: 75 parts of: 50 parts of: 50 parts of: 50 parts of: 66 parts of: 33 parts of: 33 parts of.
3. The eyesight improving and eye protecting composition according to claim 1 or 2, wherein the eyesight improving and eye protecting composition is prepared by mixing the water-decocted extracts of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion, the borneol, the pearl powder, the menthol and pharmaceutical excipients.
4. The eye-improving eye-protecting composition according to claim 3, wherein said eye-improving composition is prepared by the steps of:
(1) mixing the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion, and then decocting and extracting the mixture by water to obtain an extracting solution;
(2) mixing the borneol fine powder and the pearl powder with the extracting solution in the step (1) to obtain a mixed solution;
(3) heating and melting glycerol, propylene glycol, polyoxyl (40) stearate and potassium sorbate to obtain a water phase;
(4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution;
(5) heating and melting glyceryl monostearate, cetyl alcohol, light liquid paraffin and medium-chain fatty acid triglyceride to obtain oil phase;
(6) mixing the menthol with the oil phase obtained in the step (5) so as to obtain an oil phase mixed solution;
(7) and mixing and emulsifying the water phase mixed solution and the oil phase mixed solution to obtain the eyesight improving and eye protecting composition.
5. The eyesight improving and eye protecting composition according to any one of claims 1 to 4, wherein the eyesight improving and eye protecting composition is an external preparation;
optionally, the external preparation is an ointment, a cream, a gel or a patch;
preferably, the external preparation is a cream.
6. Use of the eyesight improving eye care composition of any one of claims 1-5 in eyesight improving eye protection for adults.
7. A method for preparing the eyesight improving and eye protecting composition as claimed in any one of claims 1 to 5, wherein the composition is prepared by mixing water-decocted extracts of wild chrysanthemum flower, glossy privet fruit, cassia seed, pipewort, mulberry leaf and dandelion with fine borneol powder, pearl powder, menthol and pharmaceutic adjuvants.
8. The method of claim 7, comprising the steps of:
(1) mixing the wild chrysanthemum, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion, and then decocting and extracting the mixture by water to obtain an extracting solution;
(2) mixing the borneol fine powder, the pearl powder and the extracting solution in the step (1) to obtain a mixed solution;
(3) heating and melting glycerol, propylene glycol, polyoxyl (40) stearate and potassium sorbate to obtain a water phase;
(4) mixing the mixed solution obtained in the step (2) with the water phase obtained in the step (3) to obtain water phase mixed solution;
(5) heating and melting glyceryl monostearate, cetyl alcohol, light liquid paraffin and medium-chain fatty acid triglyceride to obtain oil phase;
(6) mixing the menthol with the oil phase obtained in the step (5) so as to obtain an oil phase mixed solution;
(7) and mixing and emulsifying the water phase mixed solution and the oil phase mixed solution to obtain the eyesight improving and eye protecting composition.
9. The method according to claim 8, wherein in step (1), the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion are mixed and then decocted and extracted twice by adding water, the decoction is sequentially filtered, concentrated and centrifuged to obtain the extracting solution, the extracting time is 0.5-1.5 hours each time,
optionally, in the step (1), in each water decoction and extraction process, the mass ratio of the total mass of the wild chrysanthemum flower, the glossy privet fruit, the cassia seed, the pipewort, the mulberry leaf and the dandelion to water is 1: 2-5; the concentration ratio of the decoction extraction is 5-10: 1;
optionally, in the step (3), based on 10-100 parts by weight of the borneol fine powder in the step (2) and 5-50 parts by weight of the pearl powder, the mass ratio of the glycerol, the propylene glycol, the polyoxyl (40) stearate and the potassium sorbate is 60-80 parts: 30-50 parts of: 20-30 parts of: 3-10 parts of a material, wherein the heating and melting temperature is 80-90 ℃.
10. The method according to claim 8 or 9, wherein in the step (5), the ratio of the values of the glyceryl monostearate, the cetyl alcohol, the light liquid paraffin and the medium-chain fatty acid triglyceride is as follows, based on 5 to 50 parts by weight of the menthol: 60-80 parts of: 20-40 parts of: 40-60 parts of: 200-300 parts, wherein the heating and melting temperature is 80-90 ℃;
optionally, in the step (6), the mixing temperature is 80-90 ℃;
optionally, in the step (7), the emulsification treatment is carried out under the temperature condition of 80-90 ℃ and the rotation speed of 6000-7000r/min for 15-20 minutes.
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| CN115282218A (en) * | 2022-06-28 | 2022-11-04 | 深圳市艾普生物科技有限公司 | Herbal atomized composition for relieving eye fatigue and preparation method thereof |
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