CN102920911B - Traditional Chinese medicine for treating keratoconjunctivitis sicca and preparation method thereof - Google Patents
Traditional Chinese medicine for treating keratoconjunctivitis sicca and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicinal composition for treating keratoconjunctivitis sicca, which comprises the following raw material drugs: heartleaf houttuynia herb, dendrobe, mulberry leaf, medlar, yerbadetajo herb, cassia seed, multiflower knotweed vine, red bean, mulberry, kamuning, liriope spicata, America ginseng, plantain herb, fragrant solomonseal rhizome, figwort root, raw rehmannia, coral ardisia root, buerger pipewort flower, papermulberry fruit, motherwort and liquorice. Compared with a western medicament, the Chinese medicinal composition has good curative effect, relapse prevention, small toxic and side effects and low residue rate in treating keratoconjunctivitis sicca, can regulate a whole human body to achieve the effect of treating both principal and secondary aspect of disease, and is a safe and reliable Chinese medicament for treating keratoconjunctivitis sicca with remarkable curative effect.
Description
Technical field
The present invention relates to Chinese medicine technical field, relate in particular to a kind of Chinese medicine that is used for the treatment of angle conjunctival xerosis and preparation method thereof.
Background technology
Angle conjunctival xerosis is called again keratoconjunctivitis sicca, xerophthalmia, it is a kind of clinical modal chronic ocular disease, refer to the abnormal of tear quality and quantity due to a variety of causes, or tear hydrodynamics causes the unstable and ocular surface injury of tear film extremely, thereby cause a class disease of ophthalmic uncomfortable.Clinical manifestation is eye a sensation of dryness, foreign body sensation, burn feeling, gargalesthesia, vision fluctuation, blurred vision, furious, photophobia and asthenopia etc.Along with the change of people's living habit, working environment, the sickness rate of dry angle conjunctival xerosis is more and more higher, has 14.16% people to suffer from angle conjunctival xerosis in U.S. over-65s crowd, and Japan is 17.10%, and Australia is 10.13%.
In recent years, along with increasing of social senilization, video terminal worker and corneal contact lens wearer, cause the sickness rate of angle conjunctival xerosis to raise year by year, age of onset is also tending towards rejuvenation.Meanwhile, the pollution of air ambient, the unreasonable use of some drugs, extensively carrying out of the operation of eye refrangibility and cataract operation, is also the key factor that angle conjunctival xerosis patient increases increasingly.People more and more pay attention to the treatment of this disease.
At present for angle conjunctival xerosis without especially effective Therapeutic Method, the principle of western medical treatment angle conjunctival xerosis is for supplementing artificial tears, stimulate lacrimal secretion, reducing tear runs off, main method has: artificial tears's eye drip, wear the soft corneal contact lens of hydrophilic, block or sealing puncta, make hype lacrimal secretion etc., adopt of disease patient in light supplemented to artificial tears's anti symptom treatment more, patient with severe symptoms is except above-mentioned measure, give Punctal plug, antiinflammatory, immunosuppressant or hands art, these all only limit to the adjustment of eye table local state, and eye drop is not vitamin, neither eye-candy liquid, abuse collyrium can bring the problems such as the durable or untoward reaction of medicine, life-time service is probably to conjunctiva microcell, accessory lacrimal glands etc. damage, increase the weight of on the contrary angle conjunctival xerosis symptom, be helpless to the at all good of angle conjunctival xerosis, and there are various drawbacks and inconvenience.Therefore, finding a kind for the treatment of of dry eye new method safe and reliable, satisfactory effect is current problem demanding prompt solution.
In addition, Chinese medicine composition of the present invention not only regulates the immune system of human body, goes back Endocrine and nervous system has regulating action, except can obviously improving the symptom of xerophthalmia, can also improve the malaise symptoms of whole body.
Chinese medicine is the treasure of the Chinese nation, it has with respect to Western medicine the treatment of disease, and drug toxicity is low, residual rate is low, the property of medicine is gentle, be not limited to local short term therapy, better efficacy, more focus on the adjusting on human body integral, reach the effect of radical curing of disease, therefore, be more and more subject to people's attention.
Angle conjunctival xerosis belongs to Chinese medicine " Chronic conjunctivitiskeratitis ", " oligodacrya ", " refreshing water is withered itches ", " dryness syndrome " category, early has discussion in Ancient Times in China medical science.< < Plain Questions the five internal organs generate piece of writing > > and say: " normal vision relying on sufficiency of liver-blood ", although the vital essence of having pointed out the vital organs of the human body is noted in order on all, but The eye is the body opening of the liver, especially with moistening of liver blood, support as wanting.The logical correcting the deficiency and excess opinion of < < Plain Questions > > says: " kidney person water is dirty, main body fluid ", i.e. the kidney playing a chief role in regulating body fluid metabolism, upper profit order pearl.Visible, Tear is the fluid of the liver, the kidney playing a chief role in regulating body fluid metabolism, The liver and the kidney have a common source.Hepatic and renal function imbalance or deficiency of liver-blood, can cause moistening of order mistake liver blood and body fluid foster, thereby cause eyes dry, causes primary disease.
Angle conjunctival xerosis should be Chinese medicine Yin and fluid deficiency, the stagnant card of the orbit stasis of blood, and pathological changes mainly betides the meridians of Liver and kidney, and the deficiency of YIN is to fall ill originally, the source that body fluid deficiency is morbidity, and blood stasis etc. are local pathological change.Primary disease be take void as this, belongs to the card of deficiency in origin and excess in superficiality.Should Yin-nourishing and body fluid promoting in treatment, liver heat removing and eyesight improving is main, and promoting blood circulation to remove obstruction in the collateral, make integral body and local synchronization treatment, reach the effect bringing out the best in each other, the present invention is exactly a kind of Chinese medicine composition that is used for the treatment of angle conjunctival xerosis proposing on the basis of this Chinese traditional treatment principle.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine composition that is used for the treatment of angle conjunctival xerosis and preparation method thereof is provided, it has good effect aspect conjunctival xerosis for the treatment of angle, not repeatedly, drug toxicity is little for the state of an illness, and residual rate is low, can nurse one's health Whole Body, the effect for the treatment of both the principal and secondary aspects of a disease is the Chinese medicine composition of a kind of safe and reliable, evident in efficacy treatment angle conjunctival xerosis.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of angle conjunctival xerosis, it comprises following crude drug: Herba Houttuyniae, Herba Dendrobii, Folium Mori, Fructus Lycii, Herba Ecliptae, Semen Cassiae, Caulis Polygoni Multiflori, Semen Phaseoli, Fructus Mori, Folium Et Cacumen Murrayae, Radix Liriopes, Radix Panacis Quinquefolii, Herba Plantaginis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Rehmanniae, Radix Ardisiae Crenatae, Flos Eriocauli, Fructus Broussonetiae, Herba Leonuri and Radix Glycyrrhizae.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively:
Herba Houttuyniae 20 weight portion ~ 30 weight portions, Herba Dendrobii 50 weight portion ~ 60 weight portions, Folium Mori 35 weight portion ~ 45 weight portions, Fructus Lycii 70 weight portion ~ 80 weight portions, Herba Ecliptae 40 weight portion ~ 50 weight portions, Semen Cassiae 45 weight portion ~ 55 weight portions, Caulis Polygoni Multiflori 20 weight portion ~ 30 weight portions, Semen Phaseoli 15 weight portion ~ 25 weight portions, Fructus Mori 35 weight portion ~ 45 weight portions, Folium Et Cacumen Murrayae 20 weight portion ~ 30 weight portions, Radix Liriopes 35 weight portion ~ 45 weight portions, Radix Panacis Quinquefolii 40 weight portion ~ 50 weight portions, Herba Plantaginis 10 weight portion ~ 20 weight portions, Rhizoma Polygonati Odorati 25 weight portion ~ 35 weight portions, Radix Scrophulariae 25 weight portion ~ 35 weight portions, Radix Rehmanniae 30 weight portion ~ 40 weight portions, Radix Ardisiae Crenatae 25 weight portion ~ 35 weight portions, Flos Eriocauli 35 weight portion ~ 45 weight portions, Fructus Broussonetiae 20 weight portion ~ 30 weight portions, Herba Leonuri 20 weight portion ~ 30 weight portions and Radix Glycyrrhizae 20 weight portion ~ 30 weight portions.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively:
Herba Houttuyniae 22 weight portion ~ 28 weight portions, Herba Dendrobii 52 weight portion ~ 58 weight portions, Folium Mori 37 weight portion ~ 43 weight portions, Fructus Lycii 72 weight portion ~ 78 weight portions, Herba Ecliptae 42 weight portion ~ 48 weight portions, Semen Cassiae 47 weight portion ~ 53 weight portions, Caulis Polygoni Multiflori 22 weight portion ~ 28 weight portions, Semen Phaseoli 17 weight portion ~ 23 weight portions, Fructus Mori 37 weight portion ~ 43 weight portions, Folium Et Cacumen Murrayae 22 weight portion ~ 28 weight portions, Radix Liriopes 37 weight portion ~ 43 weight portions, Radix Panacis Quinquefolii 42 weight portion ~ 48 weight portions, Herba Plantaginis 12 weight portion ~ 18 weight portions, Rhizoma Polygonati Odorati 27 weight portion ~ 33 weight portions, Radix Scrophulariae 27 weight portion ~ 33 weight portions, Radix Rehmanniae 32 weight portion ~ 38 weight portions, Radix Ardisiae Crenatae 27 weight portion ~ 33 weight portions, Flos Eriocauli 37 weight portion ~ 43 weight portions, Fructus Broussonetiae 22 weight portion ~ 28 weight portions, Herba Leonuri 22 weight portion ~ 28 weight portions and Radix Glycyrrhizae 22 weight portion ~ 28 weight portions.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively:
Herba Houttuyniae 25 weight portions, Herba Dendrobii 55 weight portions, Folium Mori 40 weight portions, Fructus Lycii 75 weight portions, Herba Ecliptae 45 weight portions, Semen Cassiae 50 weight portions, Caulis Polygoni Multiflori 25 weight portions, Semen Phaseoli 20 weight portions, Fructus Mori 40 weight portions, Folium Et Cacumen Murrayae 25 weight portions, Radix Liriopes 40 weight portions, Radix Panacis Quinquefolii 45 weight portions, Herba Plantaginis 15 weight portions, Rhizoma Polygonati Odorati 30 weight portions, Radix Scrophulariae 30 weight portions, Radix Rehmanniae 35 weight portions, Radix Ardisiae Crenatae 30 weight portions, Flos Eriocauli 40 weight portions, Fructus Broussonetiae 25 weight portions, Herba Leonuri 25 weight portions and Radix Glycyrrhizae 25 weight portions.
Wherein, the Chinese medicine composition that prepared by the present invention can be prepared into dosage form for oral administration and exterior-applied formulation.
The invention provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, it comprises the following steps:
The first step, each crude drug in described Chinese medicine composition is sent in pulverizer and pulverized respectively, send in mixer and be mixed in proportion, obtain mixture, adding determining alcohol is 80% ~ 90% ethanol, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the first filtrate, the adding proportion of described ethanol and described mixture is 3:1 ~ 5:1, it is 80% ~ 90% ethanol that filtering residue is added to determining alcohol again, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the second filtrate, the adding proportion of described ethanol and described mixture is 1:1 ~ 3:1, the first filtrate and the second filtrate are mixed, obtain mixture filtrate,
Second step, the temperature of 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out 50% ~ 60% the ethanol that vacuum concentration is removed mass percent in mixture filtrate, add subsequently the water with respect to 8 ~ 10 times of mixture qualities above, be heated to micro-boiling 5 ~ 10 minutes, fully stir, be cooled to room temperature, standing 12 ~ 18 hours, filter, filtrate, the temperature of 65 ℃ ~ 75 ℃, is carried out vacuum concentration and is removed moisture under the condition of vacuum 0.07 ~ 0.09mpa, obtain and get dry extract;
The 3rd step, dry cream is sent into and in pulverizer, is ground into powder, add the ethyl acetate that accounts for its quality 10 ~ 15%, stir, standing 24 hours, filter out precipitation, temperature by filtrate at 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out vacuum concentration and remove ethyl acetate, again send in pulverizer and be ground into powder, obtain powder.
The present invention also provides the using method of Chinese medicine composition, and when the dosage form of described Chinese medicine composition is powder, it is specially powder is dissolved in distilled water, and heating for dissolving is complete, obtains crude drug concentration and is 1g/ml ~ 2g/ml, oral, every day 3 times, each 50ml.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition is eye drop, it comprises the following steps:
The first step, each crude drug in described Chinese medicine composition is sent in pulverizer and pulverized respectively, send in mixer and be mixed in proportion, obtain mixture, adding determining alcohol is 80% ~ 90% ethanol, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the first filtrate, the adding proportion of described ethanol and described mixture is 3:1 ~ 5:1, it is 80% ~ 90% ethanol that filtering residue is added to determining alcohol again, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the second filtrate, the adding proportion of described ethanol and described mixture is 1:1 ~ 3:1, the first filtrate and the second filtrate are mixed, obtain mixture filtrate,
Second step, the temperature of 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out 50% ~ 60% the ethanol that vacuum concentration is removed mass percent in mixture filtrate, add subsequently the water with respect to 8 ~ 10 times of mixture qualities above, be heated to micro-boiling 5 ~ 10 minutes, fully stir, be cooled to room temperature, standing 12 ~ 18 hours, filter, filtrate, the temperature of 65 ℃ ~ 75 ℃, is carried out vacuum concentration and is removed moisture under the condition of vacuum 0.07 ~ 0.09mpa, obtain and get dry extract;
The 3rd step, dry cream is sent into and in pulverizer, is ground into powder, add the ethyl acetate that accounts for its quality 10 ~ 15%, stir, standing 24 hours, filter out precipitation, the temperature by filtrate at 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out vacuum concentration and remove ethyl acetate, again send into and in pulverizer, be ground into powder;
The 4th step, powder in the 3rd step is added to appropriate sterilized water for injection to be dissolved as the first solution, separately with ethylparaben, sodium chloride, add after appropriate distilled water dissolving, add vitamin C sodium solution, 5 % sodium bicarbonate solutions, at 100 ℃, use flowing steam sterilization 30 min, as the second solution.By after the first solution and the merging of the second solution, stir evenly, add sterilized water for injection to 1000ml, after stirring, with filtering with microporous membrane, subpackage under aseptic condition, the crude drug concentration of described eye drop is 1g/ml ~ 2g/ml.
The present invention also provides the using method of Chinese medicine composition, and when described Chinese medicine composition is eye drop, it is specially to the above-mentioned eye drop of eye drop, every day 5 ~ 7 times, each 3 ~ 4.
The application of Chinese medicine composition described in claim 1 to 5 in the medicine for the preparation for the treatment of angle conjunctival xerosis.
Beneficial effect of the present invention:
Chinese medicine composition provided by the invention, with respect to Western medicine, has good effect aspect the conjunctival xerosis for the treatment of angle, and the state of an illness is not repeatedly, drug toxicity is little, and residual rate is low, can nurse one's health Whole Body, the effect for the treatment of both the principal and secondary aspects of a disease is the Chinese medicine of a kind of safe and reliable, evident in efficacy treatment angle conjunctival xerosis.
The specific embodiment
The invention provides a kind of Chinese medicine composition that is used for the treatment of angle conjunctival xerosis, it comprises following crude drug: Herba Houttuyniae, Herba Dendrobii, Folium Mori, Fructus Lycii, Herba Ecliptae, Semen Cassiae, Caulis Polygoni Multiflori, Semen Phaseoli, Fructus Mori, Folium Et Cacumen Murrayae, Radix Liriopes, Radix Panacis Quinquefolii, Herba Plantaginis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Rehmanniae, Radix Ardisiae Crenatae, Flos Eriocauli, Fructus Broussonetiae, Herba Leonuri and Radix Glycyrrhizae.
In described Chinese medicine composition, the weight portion of each crude drug is respectively:
Herba Houttuyniae 20 weight portion ~ 30 weight portions, Herba Dendrobii 50 weight portion ~ 60 weight portions, Folium Mori 35 weight portion ~ 45 weight portions, Fructus Lycii 70 weight portion ~ 80 weight portions, Herba Ecliptae 40 weight portion ~ 50 weight portions, Semen Cassiae 45 weight portion ~ 55 weight portions, Caulis Polygoni Multiflori 20 weight portion ~ 30 weight portions, Semen Phaseoli 15 weight portion ~ 25 weight portions, Fructus Mori 35 weight portion ~ 45 weight portions, Folium Et Cacumen Murrayae 20 weight portion ~ 30 weight portions, Radix Liriopes 35 weight portion ~ 45 weight portions, Radix Panacis Quinquefolii 40 weight portion ~ 50 weight portions, Herba Plantaginis 10 weight portion ~ 20 weight portions, Rhizoma Polygonati Odorati 25 weight portion ~ 35 weight portions, Radix Scrophulariae 25 weight portion ~ 35 weight portions, Radix Rehmanniae 30 weight portion ~ 40 weight portions, Radix Ardisiae Crenatae 25 weight portion ~ 35 weight portions, Flos Eriocauli 35 weight portion ~ 45 weight portions, Fructus Broussonetiae 20 weight portion ~ 30 weight portions, Herba Leonuri 20 weight portion ~ 30 weight portions and Radix Glycyrrhizae 20 weight portion ~ 30 weight portions.
In described Chinese medicine composition, the weight portion of each crude drug is further preferably respectively:
Herba Houttuyniae 22 weight portion ~ 28 weight portions, Herba Dendrobii 52 weight portion ~ 58 weight portions, Folium Mori 37 weight portion ~ 43 weight portions, Fructus Lycii 72 weight portion ~ 78 weight portions, Herba Ecliptae 42 weight portion ~ 48 weight portions, Semen Cassiae 47 weight portion ~ 53 weight portions, Caulis Polygoni Multiflori 22 weight portion ~ 28 weight portions, Semen Phaseoli 17 weight portion ~ 23 weight portions, Fructus Mori 37 weight portion ~ 43 weight portions, Folium Et Cacumen Murrayae 22 weight portion ~ 28 weight portions, Radix Liriopes 37 weight portion ~ 43 weight portions, Radix Panacis Quinquefolii 42 weight portion ~ 48 weight portions, Herba Plantaginis 12 weight portion ~ 18 weight portions, Rhizoma Polygonati Odorati 27 weight portion ~ 33 weight portions, Radix Scrophulariae 27 weight portion ~ 33 weight portions, Radix Rehmanniae 32 weight portion ~ 38 weight portions, Radix Ardisiae Crenatae 27 weight portion ~ 33 weight portions, Flos Eriocauli 37 weight portion ~ 43 weight portions, Fructus Broussonetiae 22 weight portion ~ 28 weight portions, Herba Leonuri 22 weight portion ~ 28 weight portions and Radix Glycyrrhizae 22 weight portion ~ 28 weight portions.
In described Chinese medicine composition, the weight portion of each crude drug is most preferably respectively:
Herba Houttuyniae 25 weight portions, Herba Dendrobii 55 weight portions, Folium Mori 40 weight portions, Fructus Lycii 75 weight portions, Herba Ecliptae 45 weight portions, Semen Cassiae 50 weight portions, Caulis Polygoni Multiflori 25 weight portions, Semen Phaseoli 20 weight portions, Fructus Mori 40 weight portions, Folium Et Cacumen Murrayae 25 weight portions, Radix Liriopes 40 weight portions, Radix Panacis Quinquefolii 45 weight portions, Herba Plantaginis 15 weight portions, Rhizoma Polygonati Odorati 30 weight portions, Radix Scrophulariae 30 weight portions, Radix Rehmanniae 35 weight portions, Radix Ardisiae Crenatae 30 weight portions, Flos Eriocauli 40 weight portions, Fructus Broussonetiae 25 weight portions, Herba Leonuri 25 weight portions and Radix Glycyrrhizae 25 weight portions.
Preferably, described Chinese medicine composition only consists of above-mentioned raw materials medicine.
The pharmacology of described each crude drug is as follows:
Herba Houttuyniae: acrid in the mouth, cold nature, enters lung, urinary bladder channel, there is heat-clearing and toxic substances removing, removing pus and relieving carbuncle, the effect of inducing diuresis for treating stranguria syndrome, for lung abscess vomiting pus, expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, pyretic toxicity carbuncle sore, snakeworm is wanted first-class card, and Herba Houttuyniae has the effects such as clearing heat, detoxicating, dispelling dampness, antiinflammatory, antipathogen, main component certain herbaceous plants with big flowers acyl acetaldehyde and lauryl aldehyde in its volatile oil, all can promote body's immunity.
Herba Dendrobii: cold nature, sweet in the mouth, returns stomach, kidney channel, has reinforcing stomach reg fluid, the effect of nourishing YIN and clearing away heat.Cure mainly cloudy impairment of body fluid and lose, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, the cards such as poor vision.
Folium Mori: sweet in the mouth, hardship; Cold in nature.Return lung, Liver Channel, the effect with dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, for anemopyretic cold and conjunctival congestion and swelling pain, wind-fire order disease, dryness-heat impairing the lung, the few expectorant of dry cough, < < Bencao Jingshu > >: < < herbal classic > > odorlessness.It cures mainly in detail, should be that sweet in the mouth gas is cold nontoxic.So sweet beneficial blood, so cold removing heat from blood, sweet cold being harmonious, therefore the therapeutic method to keep the adverse QI flowing downwards and tonifying YIN.With the main deficiency of YIN cold and heat of energy, and because of interior-heat perspiration.Its property is held concurrently dry, therefore can remove beriberi edema, sharp intestine and small intestine again.The golden gas of former official report, therefore can remove wind again.Through frost the respectful clearly of the world that get both, therefore again can improving eyesight and quench the thirst.Send out person, after blood, therefore beneficial blood again can long hair, therefore removing heat from blood emesis blood again.Close carbuncle mouth, net for catching birds or fish is worn the palm, treats soup fire, and all refrigerant merit of enriching blood also.
Fructus Lycii: sweet in the mouth, property are flat, enter liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, be mainly used in soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; The cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood, Fructus Lycii contains multivitamin, aminoacid, has the effect that improves body immunity.
Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, is used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.
Semen Cassiae: bitter in the mouth, cold nature, enters large intestine, kidney, Liver Channel, has purging liver-fire, the effect of loosening bowel to relieve constipation, for the puckery pain of conjunctival congestion, the many tear of photophobia, the cards such as dizzy, poor vision, constipation of having a headache.< < Bencao Jingshu > >: Semen Cassiae, its salty in the mouth is flat, and it is nontoxic with sweet being slightly cold of hardship that < < does not record > > benefit.The salty aqueous vapor that obtains, rusticly sweet, hardship can expel the heat-evil, the flat gastric qi of closing, cold can expelling the heat-evil by tonifying YIN, the positive medicine of liver meridian man is also.Also enter gallbladder kidney.Liver opening at eye, gb 1 God Light belongs to kidney, therefore main optic atrohic blindness order is excessive, the red tunica albuginea of skin, swelling ophthalmalgia lacrimation.< < does not record the double blue-purple lips for the treatment of of > >.< < herbal classic > > takes beneficial with nothing left person for a long time, tonifying YIN expels the heat-evil, due to the gas of large invigorating the liver and kidney also.
Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is flat; GUIXIN, Liver Channel, having can tranquilizing by nourishing the heart, the effect of dispelling wind and removing obstruction in the collateral, cures mainly insomnia and dreamful sleep, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, the cards such as wind skin ulcer scabies.
Semen Phaseoli: property is flat, sweet in the mouth, acid, have the diuretic kind that disappears, and the effect of removing toxic substances and promoting pus discharge, for cards such as edema distension, beriberi edema, jaundice dark coloured urine, rheumatism pyretic arthralgia, carbuncle sore tumefacting virus, abdominalgia with intestinal abscess.
Fructus Mori: sweet in the mouth, acid, cold in nature, GUIXIN, liver, kidney channel, have the YIN nourishing of enriching blood, the effect of promoting the production of body fluid and moisturizing.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, the card such as Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.
Folium Et Cacumen Murrayae: acrid in the mouth, micro-hardship, warm in nature, return liver, stomach warp, has promoting the circulation of QI to relieve pain, and the effect of promoting blood circulation to remove blood stasis, cures mainly stomachache, rheumatic arthralgia; External treatment toothache, tumbling and swelling, the cards such as worm venom.
Radix Liriopes: sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, the effect that lung moistening clears away heart-fire, for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as dryness of the intestine constipation.
Radix Panacis Quinquefolii: sweet in the mouth, micro-hardship, cool in nature, GUIXIN, lung, kidney channel, have boosting qi and nourishing yin, and the effect of clearing away heat and promoting production of body fluid cures mainly the deficiency of vital energy thanks to cloudy, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired tired, quenches one's thirst, the cards such as dryness of the mouth and throat.
Herba Plantaginis: sweet in the mouth, light, cold nature, returns lung meridian, Liver Channel, kidney channel, urinary bladder channel, and the effect of have clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal, improving eyesight, eliminating the phlegm, cures mainly main dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough is breathed heavily, and Herba Plantaginis has diuresis, calculus removing effect.
Rhizoma Polygonati Odorati: sweet in the mouth, property is flat, attaches to the lung and stomach meridians, and has the effect of nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, cures mainly cough caused by dryness; Chronic cough; The dry throat and mouth of the cloudy liquid consumption of calentura wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; The cards such as muscle arteries and veins spasm and pain.
Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel, there is clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing is supported the effect of kidney, curing mainly pathogenic warmth joins the army, the pericardium that caves in, maculae caused by violent heat pathogen, the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin.
Radix Rehmanniae: sweet in the mouth, hardship, cold in nature, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, eliminating blood stasis to promote regeneration of blood, and the effect of YIN nourishing and the production of body fluid promoting cures mainly the Kidney-Yin cards of being robbed such as fever of the body is thirsty of heat as battalion minute; Or calentura later stage low grade fever does not move back; Chronic disease card belongs to yin asthenia generating intrinsic heat person; The thirst and drinking of accumulated heat in the lung and stomach, quenches one's thirst vexed, thirsty few Tianjin that stomach-Yin is injured; The having blood in stool of bleeding due to blood-heat, metrostaxis; The purple black card that waits of a speckle of heat in blood poison Sheng.
Radix Ardisiae Crenatae: mildly bitter flavor, pungent, property is flat, returns lung, Liver Channel, has the effect of removing toxic substances and promoting subsidence of swelling, promoting blood circulation and stopping pain, expelling wind and removing dampness, cures mainly the cards such as laryngopharynx swelling and pain, rheumatic arthralgia, traumatic injury.
Flos Eriocauli: acrid in the mouth, sweet, property is put down, return liver, stomach warp, there is the effect of wind-dispelling heat-dissipating, improving acuity of vision and removing nebula, for cards such as conjunctival congestion and swelling pain, the many tear of photophobia, headache due to pathogenic wind-heat, toothache, staphylococcus aureus, bacterium flexneri, Bacillus typhi, escherichia coli, bacillus pyocyaneus etc. are had to stronger inhibitory action.
Fructus Broussonetiae: sweet in the mouth, cold in nature, return liver, kidney channel, there is the kidney invigorating liver heat removing, the effect of improving eyesight diuresis, cures mainly deficiency of the liver and kindey, soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, has a dizzy spell, the card such as edema distension.
Herba Leonuri: latin name
leonuri Herba, bitter in the mouth, pungent, cold nature, enters liver, pericardium channel, has promoting blood flow to regulate menstruation, and the effect of inducing diuresis to remove edema, cures mainly menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria, the cards such as acute nephritis edema.
Radix Glycyrrhizae: property is flat, sweet in the mouth, enters 12 warps, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription, for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse and deficiency of spleen-QI and stomach-QI, fatigue and weakness, ulcer sores, laryngopharynx swelling and pain, asthma and cough, is in harmonious proportion the strong of some drugs.
Chinese medicine composition prepared by the present invention can be prepared into dosage form for oral administration and exterior-applied formulation, and dosage form for oral administration can adopt the Chinese medicine for oral administration dosage form of any routine, is preferably powder, and exterior-applied formulation can adopt the external application Chinese medicine dosage form of any routine, is preferably eye drop.
Preferably, the present invention is the oral powder external eye drop of holding concurrently simultaneously, thus treatment angle conjunctival xerosis.
The invention provides the preparation method of above-mentioned Chinese medicine composition, when the dosage form of described Chinese medicine composition is powder, it comprises the following steps:
The first step, each crude drug in described Chinese medicine composition is sent in pulverizer and pulverized respectively, send in mixer and be mixed in proportion, obtain mixture, adding determining alcohol is 80% ~ 90% ethanol, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the first filtrate, the adding proportion of described ethanol and described mixture is 3:1 ~ 5:1, it is 80% ~ 90% ethanol that filtering residue is added to determining alcohol again, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the second filtrate, the adding proportion of described ethanol and described mixture is 1:1 ~ 3:1, the first filtrate and the second filtrate are mixed, obtain mixture filtrate,
Second step, the temperature of 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out 50% ~ 60% the ethanol that vacuum concentration is removed mass percent in mixture filtrate, add subsequently the water with respect to 8 ~ 10 times of mixture qualities above, be heated to micro-boiling 5 ~ 10 minutes, fully stir, be cooled to room temperature, standing 12 ~ 18 hours, filter, filtrate, the temperature of 65 ℃ ~ 75 ℃, is carried out vacuum concentration and is removed moisture under the condition of vacuum 0.07 ~ 0.09mpa, obtain and get dry extract;
The 3rd step, dry cream is sent into and in pulverizer, is ground into powder, add the ethyl acetate that accounts for its quality 10 ~ 15%, stir, standing 24 hours, filter out precipitation, temperature by filtrate at 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out vacuum concentration and remove ethyl acetate, again send in pulverizer and be ground into powder, obtain powder.
Preferably, described method only consists of above-mentioned steps.
The present invention also provides the using method of above-mentioned Chinese medicine composition composition powders, and powder is dissolved in distilled water, and heating for dissolving is complete, obtains crude drug concentration and is 1g/ml ~ 2g/ml, oral, every day 3 times, each 50ml.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, and when the dosage form of described Chinese medicine composition is eye drop, it comprises the following steps:
The first step, each crude drug in described Chinese medicine composition is sent in pulverizer and pulverized respectively, send in mixer and be mixed in proportion, obtain mixture, adding determining alcohol is 80% ~ 90% ethanol, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the first filtrate, the adding proportion of described ethanol and described mixture is 3:1 ~ 5:1, it is 80% ~ 90% ethanol that filtering residue is added to determining alcohol again, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the second filtrate, the adding proportion of described ethanol and described mixture is 1:1 ~ 3:1, the first filtrate and the second filtrate are mixed, obtain mixture filtrate,
Second step, the temperature of 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out 50% ~ 60% the ethanol that vacuum concentration is removed mass percent in mixture filtrate, add subsequently the water with respect to 8 ~ 10 times of mixture qualities above, be heated to micro-boiling 5 ~ 10 minutes, fully stir, be cooled to room temperature, standing 12 ~ 18 hours, filter, filtrate, the temperature of 65 ℃ ~ 75 ℃, is carried out vacuum concentration and is removed moisture under the condition of vacuum 0.07 ~ 0.09mpa, obtain and get dry extract;
The 3rd step, dry cream is sent into and in pulverizer, is ground into powder, add the ethyl acetate that accounts for its quality 10 ~ 15%, stir, standing 24 hours, filter out precipitation, the temperature by filtrate at 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out vacuum concentration and remove ethyl acetate, again send into and in pulverizer, be ground into powder;
The 4th step, powder in the 3rd step is added to appropriate sterilized water for injection to be dissolved as the first solution, separately with ethylparaben, sodium chloride, add after appropriate distilled water dissolving, add vitamin C sodium solution, 5 % sodium bicarbonate solutions, at 100 ℃, use flowing steam sterilization 30 min, as the second solution.By after the first solution and the merging of the second solution, stir evenly, add sterilized water for injection to 1000ml, after stirring, with filtering with microporous membrane, subpackage under aseptic condition, the crude drug concentration of described eye drop is 1g/ml ~ 2g/ml.
Preferably, described method only consists of above-mentioned steps.
The present invention also provides the using method of above-mentioned eye drop, and it is specially to the above-mentioned eye drop of eye drop, every day 5 ~ 7 times, each 3 ~ 4.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition composition powders 1
By Herba Houttuyniae 25g, Herba Dendrobii 55g, Folium Mori 40g, Fructus Lycii 75g, Herba Ecliptae 45g, Semen Cassiae 50g, Caulis Polygoni Multiflori 25g, Semen Phaseoli 20g, Fructus Mori 40g, Folium Et Cacumen Murrayae 25g, Radix Liriopes 40g, Radix Panacis Quinquefolii 45g, Herba Plantaginis 15g, Rhizoma Polygonati Odorati 30g, Radix Scrophulariae 30g, Radix Rehmanniae 35g, Radix Ardisiae Crenatae 30g, Flos Eriocauli 40g, Fructus Broussonetiae 25g, Herba Leonuri 25g and Radix Glycyrrhizae 25g send in pulverizer and pulverize respectively, send in mixer and mix, obtain mixture, adding determining alcohol is 90% ethanol 3kg, heating and refluxing extraction 4 hours, filter, obtain the first filtrate, it is 90% ethanol 1.5kg that filtering residue is added to determining alcohol again, heating and refluxing extraction 4 hours, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, obtain mixture filtrate, temperature at 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove 60% ethanol of mass percent in mixture filtrate, the water that adds subsequently 7kg, be heated to micro-boiling 10 minutes, fully stir, be cooled to room temperature, standing 18 hours, filter, filtrate is the temperature of 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove moisture, obtain and get dry extract, dry cream is sent into and in pulverizer, is ground into powder, the ethyl acetate that adds 74g, stir, standing 24 hours, filter out precipitation, temperature by filtrate at 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove ethyl acetate, again send into and in pulverizer, be ground into powder, obtain powder 1.
Embodiment 2 Chinese medicine composition composition powders 2
By Herba Houttuyniae 28g, Herba Dendrobii 58g, Folium Mori 43g, Fructus Lycii 78g, Herba Ecliptae 48g, Semen Cassiae 53g, Caulis Polygoni Multiflori 28g, Semen Phaseoli 23g, Fructus Mori 43g, Folium Et Cacumen Murrayae 28g, Radix Liriopes 43g, Radix Panacis Quinquefolii 48g, Herba Plantaginis 18g, Rhizoma Polygonati Odorati 33g, Radix Scrophulariae 33g, Radix Rehmanniae 38g, Radix Ardisiae Crenatae 33g, Flos Eriocauli 43g, Fructus Broussonetiae 28g, Herba Leonuri 28g and Radix Glycyrrhizae 28g send in pulverizer and pulverize respectively, send in mixer and mix, obtain mixture, adding determining alcohol is 90% ethanol 4kg, heating and refluxing extraction 4 hours, filter, obtain the first filtrate, it is 90% ethanol 1.8kg that filtering residue is added to determining alcohol again, heating and refluxing extraction 4 hours, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, obtain mixture filtrate, temperature at 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove 60% ethanol of mass percent in mixture filtrate, the water that adds subsequently 7kg, be heated to micro-boiling 10 minutes, fully stir, be cooled to room temperature, standing 18 hours, filter, filtrate is the temperature of 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove moisture, obtain and get dry extract, dry cream is sent into and in pulverizer, is ground into powder, the ethyl acetate that adds 80g, stir, standing 24 hours, filter out precipitation, temperature by filtrate at 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove ethyl acetate, again send into and in pulverizer, be ground into powder, obtain powder 2.
Embodiment 3 Chinese medicine composition eye drops 1
By Herba Houttuyniae 25g, Herba Dendrobii 55g, Folium Mori 40g, Fructus Lycii 75g, Herba Ecliptae 45g, Semen Cassiae 50g, Caulis Polygoni Multiflori 25g, Semen Phaseoli 20g, Fructus Mori 40g, Folium Et Cacumen Murrayae 25g, Radix Liriopes 40g, Radix Panacis Quinquefolii 45g, Herba Plantaginis 15g, Rhizoma Polygonati Odorati 30g, Radix Scrophulariae 30g, Radix Rehmanniae 35g, Radix Ardisiae Crenatae 30g, Flos Eriocauli 40g, Fructus Broussonetiae 25g, Herba Leonuri 25g and Radix Glycyrrhizae 25g send in pulverizer and pulverize respectively, send in mixer and mix, obtain mixture, adding determining alcohol is 90% ethanol 3kg, heating and refluxing extraction 4 hours, filter, obtain the first filtrate, it is 90% ethanol 1.5kg that filtering residue is added to determining alcohol again, heating and refluxing extraction 4 hours, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, obtain mixture filtrate, temperature at 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove 60% ethanol of mass percent in mixture filtrate, the water that adds subsequently 7kg, be heated to micro-boiling 10 minutes, fully stir, be cooled to room temperature, standing 18 hours, filter, filtrate is the temperature of 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove moisture, obtain and get dry extract, dry cream is sent into and in pulverizer, is ground into powder, the ethyl acetate that adds 74g, stir, standing 24 hours, filter out precipitation, temperature by filtrate at 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove ethyl acetate, again send into and in pulverizer, be ground into powder, get this powder of 1000g and add the dissolving of 300ml sterilized water for injection as the first solution, separately with 30g ethylparaben, sodium chloride 450g, add after the dissolving of 300ml distilled water, adding concentration is 10% vitamin C sodium solution 100ml, 5 % sodium bicarbonate solution 100ml, at 100 ℃, use flowing steam sterilization 30 min, as the second solution, by after the first solution and the merging of the second solution, stir evenly, add sterilized water for injection to 1000ml, after stirring, with filtering with microporous membrane, subpackage under aseptic condition, every bottle of 10ml, the crude drug concentration of described eye drop 1 is 1g/ml.
Embodiment 4 Chinese medicine composition eye drops 2
By Herba Houttuyniae 22g, Herba Dendrobii 52g, Folium Mori 37g, Fructus Lycii 72g, Herba Ecliptae 42g, Semen Cassiae 47g, Caulis Polygoni Multiflori 22g, Semen Phaseoli 17g, Fructus Mori 37g, Folium Et Cacumen Murrayae 22g, Radix Liriopes 37g, Radix Panacis Quinquefolii 42g, Herba Plantaginis 12g, Rhizoma Polygonati Odorati 27g, Radix Scrophulariae 27g, Radix Rehmanniae 32g, Radix Ardisiae Crenatae 27g, Flos Eriocauli 37g, Fructus Broussonetiae 22g, Herba Leonuri 22g and Radix Glycyrrhizae 22 g send in pulverizer and pulverize respectively, send in mixer and mix, obtain mixture, adding determining alcohol is 90% ethanol 2.5kg, heating and refluxing extraction 4 hours, filter, obtain the first filtrate, it is 90% ethanol 1kg that filtering residue is added to determining alcohol again, heating and refluxing extraction 4 hours, filter, obtain the second filtrate, the first filtrate and the second filtrate are mixed, obtain mixture filtrate, temperature at 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove 60% ethanol of mass percent in mixture filtrate, the water that adds subsequently 6kg, be heated to micro-boiling 10 minutes, fully stir, be cooled to room temperature, standing 18 hours, filter, filtrate is the temperature of 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove moisture, obtain and get dry extract, dry cream is sent into and in pulverizer, is ground into powder, the ethyl acetate that adds 74g, stir, standing 24 hours, filter out precipitation, temperature by filtrate at 75 ℃, under the condition of vacuum 0.09mpa, carry out vacuum concentration and remove ethyl acetate, again send into and in pulverizer, be ground into powder, get this powder of 1000g and add the dissolving of 300ml sterilized water for injection as the first solution, separately with 30g ethylparaben, sodium chloride 450g, add after the dissolving of 300ml distilled water, adding concentration is 10% vitamin C sodium solution 100ml, 5 % sodium bicarbonate solution 100ml, at 100 ℃, use flowing steam sterilization 30 min, as the second solution, by after the first solution and the merging of the second solution, stir evenly, add sterilized water for injection to 1000ml, after stirring, with filtering with microporous membrane, subpackage under aseptic condition, every bottle of 10ml, the crude drug concentration of described eye drop 1 is 1g/ml.
Embodiment 5 clinical experiments
General clinical data
Select in July, 2009～2011 year the author in October place hospital to accept altogether angle conjunctival xerosis patient 178 examples for medical treatment, male 92 examples wherein, female's 86 examples, at 29～62 years old age, average 37.5 years old, are divided into treatment group 90 examples, matched group 88 examples at random.The data such as two groups of sexes, age, the course of disease are learned by statistics and are processed no significant difference (P > 0.05).
Diagnostic criteria
The diagnosis of angle conjunctival xerosis is according to patient's the symptoms such as xerophthalmia scheorma sense, foreign body sensation, burn feeling and blurred vision, 3 inspections of row angle conjunctival xerosis: (1) Schimer's test (Schimer I test).Need not show fiber crops, get tears detecting filter strip (Tianjin Jingming New Technological Development Co., Ltd.), one end folds 5 mm, be placed in 1/3 place, lower eyelid China and foreign countries, after 5 min, take out, record the wetted length that rise at filter paper bar autofolding place, < 10 mm are positive.(2) breakup time of tear film (BUT) is measured.With normal saline, bedew the fluorescein sodium part of phosphor strip (Tianjin Jingming New Technological Development Co., Ltd.), then contact gently conjunctival sac, twinkle after the several seconds, under slit lamp, observe the time that cornea dry spot occurs, survey altogether 3 times, average, < 10 s are positive.(3) cornea fluorescent staining.Method, with (2), is observed anterior corneal surface and is had or not fluorescent staining under slit lamp, has positive.Two result positives in above-mentioned check result, can be diagnosed as angle conjunctival xerosis in conjunction with symptom and medical history.
Therapeutic Method
The Chinese powder medicine 1 of the treatment group embodiment of the present invention 1 preparation for oral administration, is dissolved in powder 1 in distilled water, and heating is dissolved completely, obtain the solution of 1g/ml, oral, every day 3 times, each 50ml, meanwhile, with the traditional Chinese medicine eye drops 1 of embodiment 3 preparations, every day 5 ~ 7 times, each 3 ~ 4, treat continuously further consultation 1 time weekly during treatment 1 month, the improvement situation that observes the symptoms, carries out corneal dyeing, Schimer's test before and after treatment.
The local eye dripping of matched group is liked beautiful eye drop (the towering Pharmaceutical of Japan), 3～6 times/d, treat continuously 1 month, and further consultation 1 time weekly during treatment, the improvement situation that observes the symptoms, carries out corneal dyeing, Schimer's test before and after treatment.
Adopt treatment by Chinese herbs of the present invention front and back symptoms
According to being envious, shedding tears, blurred vision, headache, nausea and vomiting, dizzy these 6 malaise symptoms orders of severity mark respectively and calculate each index integration and total mark.0 minute: asymptomatic; 1 minute: once in a while, after having a rest, alleviate, to how many relevant with eye; 5 minutes: often, to how many without obviously relevant with eye, impact life and work quality; 9 minutes: continue, with uncorrelated with eye, have a strong impact on life and work quality.
The standard of curative effect evaluation
The industry standard < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > that curative effect determinate standard is promulgated with reference to State Administration of Traditional Chinese Medicine; cure: transference cure; corneal dyeing disappears, and Schirmer test is repeatedly measured and is greater than 10 mm/5 mim; Take a turn for the better: symptom alleviates, corneal dyeing reduces, and lacrimal secretion is repeatedly measured in Schirmer test to be increased to some extent; Do not heal: symptom is without improvement, corneal dyeing is unchanged or increase, and lacrimal secretion is repeatedly measured in Schirmer test not to be increased.
Statistical method
Adopt SPSS 17. 0 softwares to carry out data analysis, relatively adopt t check before and after two groups of treatments, enumeration data relatively adopts χ
2check.
Result
Adopt Chinese medicine composition composition powders 1 of the present invention and eye drop 1 treatment front and back symptom score comparison, the results are shown in Table 1.
Symptom score before and after table 1 employing Chinese powder medicine of the present invention and eye drop patient treatment (
± s)
| Time | Furious | Shed tears | Blurred vision | Headache | Nausea and vomiting | Dizzy |
| Before treatment | 1.29 +0.28 | 3.76 +0.49 | 1.81 +0.19 | 1.26 +0.36 | 0.79 +0.23 | 0.59 +0.06 |
| After treatment | 0.31 +0.17 | 1.21 +0.63 | 1.17 +0.13 | 0.72 +0.45 | 0.18 +0.08 | 0.21 +0.03 |
As can be seen from Table 1, adopt conjunctival xerosis treatment rear various malaise symptoms in treatment by Chinese herbs of the present invention angle obviously to reduce, thereby prove that it has extraordinary curative effect to treatment angle conjunctival xerosis.
Before and after treatment, two groups of eye Schimer's test contrasts, the results are shown in Table 2.
Two groups of eye Schimer's test contrasts before and after table 2 treatment
| Group | Time | <5mm/5min | 6~10mm/5min | >10mm/5min |
| Treatment group | Before treatment | 78 | 12 | 0 |
| ? | After treatment | 8 | 39 | 43 |
| Matched group | Before treatment | 73 | 15 | 0 |
| ? | After treatment | 41 | 35 | 12 |
Before and after treatment, two groups of eye corneal dyeing contrasts, the results are shown in Table 3.
Two groups of eye corneal dyeing contrasts before and after table 3 treatment
| Group | Time | Non-coloring | Small size is painted | Large-area colouring |
| Treatment group | Before treatment | 7 | 29 | 54 |
| ? | After treatment | 37 | 41 | 12 |
| Matched group | Before treatment | 5 | 31 | 52 |
| ? | After treatment | 11 | 33 | 44 |
General curative effect comparison, the results are shown in Table 4.
Table 4 liang group general curative effect comparison
| Group | Number of cases | Cure | Take a turn for the better | Do not heal | Total effective rate (%) |
| Treatment group | 90 | 73 | 14 | 3 | 96.7% |
| Matched group | 88 | 42 | 19 | 27 | 69.3% |
From table 2 to table 4, can find out, adopt Chinese medicine composition composition powders of the present invention and eye drop can better treat angle conjunctival xerosis, for corneal dyeing, lacrimal secretion, be significantly improved.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (7)
1. the Chinese medicine composition that is used for the treatment of angle conjunctival xerosis, is characterized in that: by following crude drug, made: Herba Houttuyniae, Herba Dendrobii, Folium Mori, Fructus Lycii, Herba Ecliptae, Semen Cassiae, Caulis Polygoni Multiflori, Semen Phaseoli, Fructus Mori, Folium Et Cacumen Murrayae, Radix Liriopes, Radix Panacis Quinquefolii, Herba Plantaginis, Rhizoma Polygonati Odorati, Radix Scrophulariae, Radix Rehmanniae, Radix Ardisiae Crenatae, Flos Eriocauli, Fructus Broussonetiae, Herba Leonuri and Radix Glycyrrhizae;
In described Chinese medicine composition, the weight portion of each crude drug is respectively, Herba Houttuyniae 20 weight portion ~ 30 weight portions, Herba Dendrobii 50 weight portion ~ 60 weight portions, Folium Mori 35 weight portion ~ 45 weight portions, Fructus Lycii 70 weight portion ~ 80 weight portions, Herba Ecliptae 40 weight portion ~ 50 weight portions, Semen Cassiae 45 weight portion ~ 55 weight portions, Caulis Polygoni Multiflori 20 weight portion ~ 30 weight portions, Semen Phaseoli 15 weight portion ~ 25 weight portions, Fructus Mori 35 weight portion ~ 45 weight portions, Folium Et Cacumen Murrayae 20 weight portion ~ 30 weight portions, Radix Liriopes 35 weight portion ~ 45 weight portions, Radix Panacis Quinquefolii 40 weight portion ~ 50 weight portions, Herba Plantaginis 10 weight portion ~ 20 weight portions, Rhizoma Polygonati Odorati 25 weight portion ~ 35 weight portions, Radix Scrophulariae 25 weight portion ~ 35 weight portions, Radix Rehmanniae 30 weight portion ~ 40 weight portions, Radix Ardisiae Crenatae 25 weight portion ~ 35 weight portions, Flos Eriocauli 35 weight portion ~ 45 weight portions, Fructus Broussonetiae 20 weight portion ~ 30 weight portions, Herba Leonuri 20 weight portion ~ 30 weight portions and Radix Glycyrrhizae 20 weight portion ~ 30 weight portions.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively, Herba Houttuyniae 22 weight portion ~ 28 weight portions, Herba Dendrobii 52 weight portion ~ 58 weight portions, Folium Mori 37 weight portion ~ 43 weight portions, Fructus Lycii 72 weight portion ~ 78 weight portions, Herba Ecliptae 42 weight portion ~ 48 weight portions, Semen Cassiae 47 weight portion ~ 53 weight portions, Caulis Polygoni Multiflori 22 weight portion ~ 28 weight portions, Semen Phaseoli 17 weight portion ~ 23 weight portions, Fructus Mori 37 weight portion ~ 43 weight portions, Folium Et Cacumen Murrayae 22 weight portion ~ 28 weight portions, Radix Liriopes 37 weight portion ~ 43 weight portions, Radix Panacis Quinquefolii 42 weight portion ~ 48 weight portions, Herba Plantaginis 12 weight portion ~ 18 weight portions, Rhizoma Polygonati Odorati 27 weight portion ~ 33 weight portions, Radix Scrophulariae 27 weight portion ~ 33 weight portions, Radix Rehmanniae 32 weight portion ~ 38 weight portions, Radix Ardisiae Crenatae 27 weight portion ~ 33 weight portions, Flos Eriocauli 37 weight portion ~ 43 weight portions, Fructus Broussonetiae 22 weight portion ~ 28 weight portions, Herba Leonuri 22 weight portion ~ 28 weight portions and Radix Glycyrrhizae 22 weight portion ~ 28 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively, Herba Houttuyniae 25 weight portions, Herba Dendrobii 55 weight portions, Folium Mori 40 weight portions, Fructus Lycii 75 weight portions, Herba Ecliptae 45 weight portions, Semen Cassiae 50 weight portions, Caulis Polygoni Multiflori 25 weight portions, Semen Phaseoli 20 weight portions, Fructus Mori 40 weight portions, Folium Et Cacumen Murrayae 25 weight portions, Radix Liriopes 40 weight portions, Radix Panacis Quinquefolii 45 weight portions, Herba Plantaginis 15 weight portions, Rhizoma Polygonati Odorati 30 weight portions, Radix Scrophulariae 30 weight portions, Radix Rehmanniae 35 weight portions, Radix Ardisiae Crenatae 30 weight portions, Flos Eriocauli 40 weight portions, Fructus Broussonetiae 25 weight portions, Herba Leonuri 25 weight portions and Radix Glycyrrhizae 25 weight portions.
4. Chinese medicine composition claimed in claim 1, is characterized in that: described Chinese medicine composition is prepared into dosage form for oral administration or exterior-applied formulation.
5. the preparation method of Chinese medicine composition described in claim 1 to 4 any one, is characterized in that: the dosage form of described Chinese medicine composition is powder, comprise the following steps,
The first step, each crude drug in described Chinese medicine composition is sent in pulverizer and pulverized respectively, send in mixer and be mixed in proportion, obtain mixture, adding determining alcohol is 80% ~ 90% ethanol, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the first filtrate, while extracting for the first time, the adding proportion of described ethanol and described mixture is 3:1 ~ 5:1, it is 80% ~ 90% ethanol that filtering residue is added to determining alcohol again, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the second filtrate, while extracting for the second time, the adding proportion of described ethanol and described mixture is 1:1 ~ 3:1, the first filtrate and the second filtrate are mixed, obtain mixture filtrate,
Second step, the temperature of 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out the ethanol that vacuum concentration is removed 50% ~ 60% mass percent in mixture filtrate, add subsequently the water with respect to 8 ~ 10 times of mixture qualities above, be heated to micro-boiling 5 ~ 10 minutes, fully stir, be cooled to room temperature, standing 12 ~ 18 hours, filter, filtrate, the temperature of 65 ℃ ~ 75 ℃, is carried out vacuum concentration and is removed moisture under the condition of vacuum 0.07 ~ 0.09mpa, obtain and get dry extract;
The 3rd step, dry cream is sent into and in pulverizer, is ground into powder, add the ethyl acetate that accounts for its quality 10 ~ 15%, stir, standing 24 hours, filter out precipitation, temperature by filtrate at 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out vacuum concentration and remove ethyl acetate, again send in pulverizer and be ground into powder, obtain powder.
6. the preparation method of Chinese medicine composition described in claim 1 to 4 any one, is characterized in that: the dosage form of described Chinese medicine composition is eye drop, comprise the following steps,
The first step, each crude drug in described Chinese medicine composition is sent in pulverizer and pulverized respectively, send in mixer and be mixed in proportion, obtain mixture, adding determining alcohol is 80% ~ 90% ethanol, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the first filtrate, while extracting for the first time, the adding proportion of described ethanol and described mixture is 3:1 ~ 5:1, it is 80% ~ 90% ethanol that filtering residue is added to determining alcohol again, heating and refluxing extraction 2 ~ 4 hours, filter, obtain the second filtrate, while extracting for the second time, the adding proportion of described ethanol and described mixture is 1:1 ~ 3:1, the first filtrate and the second filtrate are mixed, obtain mixture filtrate,
Second step, the temperature of 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out the ethanol that vacuum concentration is removed 50% ~ 60% mass percent in mixture filtrate, add subsequently the water with respect to 8 ~ 10 times of mixture qualities above, be heated to micro-boiling 5 ~ 10 minutes, fully stir, be cooled to room temperature, standing 12 ~ 18 hours, filter, filtrate, the temperature of 65 ℃ ~ 75 ℃, is carried out vacuum concentration and is removed moisture under the condition of vacuum 0.07 ~ 0.09mpa, obtain and get dry extract;
The 3rd step, dry cream is sent into and in pulverizer, is ground into powder, add the ethyl acetate that accounts for its quality 10 ~ 15%, stir, standing 24 hours, filter out precipitation, the temperature by filtrate at 65 ℃ ~ 75 ℃, under the condition of vacuum 0.07 ~ 0.09mpa, carry out vacuum concentration and remove ethyl acetate, again send into and in pulverizer, be ground into powder;
The 4th step, powder in the 3rd step is added to appropriate sterilized water for injection to be dissolved as the first solution, separately with ethylparaben, sodium chloride, add after appropriate distilled water dissolving, add vitamin C sodium solution, 5 % sodium bicarbonate solutions, at 100 ℃, use flowing steam sterilization 30 min, as the second solution;
By after the first solution and the merging of the second solution, stir evenly, add sterilized water for injection to 1000ml, after stirring, with filtering with microporous membrane, subpackage under aseptic condition, the crude drug concentration of described eye drop is 1g/ml ~ 2g/ml.
7. the application of the Chinese medicine composition described in claim 1 to 4 any one in the medicine for the preparation for the treatment of angle conjunctival xerosis.
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| CN102920911A (en) | 2013-02-13 |
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