CN102940753B - Pills for treating glaucoma and preparation method - Google Patents
Pills for treating glaucoma and preparation method Download PDFInfo
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- CN102940753B CN102940753B CN201210510703.XA CN201210510703A CN102940753B CN 102940753 B CN102940753 B CN 102940753B CN 201210510703 A CN201210510703 A CN 201210510703A CN 102940753 B CN102940753 B CN 102940753B
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Abstract
The invention discloses pills for treating glaucoma and a preparation method, and belongs to the field of Chinese medicaments. Active ingredients of the pills consist of the following raw materials in parts by weight: 100 to 130 parts of lotus leaf, 90 to 120 parts of cassia seed, 75 to 95 parts of double hook, 70 to 90 parts of self-heal, 65 to 85 parts of pinellia tuber, 60 to 80 parts of motherwort fruit, 55 to 75 parts of rhizoma alismatis, 50 to 70 parts of white chrysanthemum, 45 to 65 parts of pyrrosia, 40 to 60 parts of mother of pearl, 35 to 55 parts of ligusticum, 35 to 50 parts of plantain seed, 30 to 45 parts of Baikal skullcap root, 30 to 40 parts of pipewort, 25 to 40 parts of areca nut, 20 to 35 parts of indigowoad leaf, 15 to 30 parts of rhizoma cyperi, 10 to 25 parts of fructus evodiae, 5 to 20 parts of pinellia pedatisecta schott, and 5 to 15 parts of bat dung. The formula is fine; according to the principles of liver and pulmonary tuberculosis heat and phlegm-damp function injury for initiating the glaucoma, medicaments for relieving liver heat and tonifying lung and qi are taken as monarchs, medicaments for clearing heat and eliminating phlegm are taken as ministers, and medicaments for removing damp and tonifying deficiency are taken as assistants and guides, so that the oxidation resistance of the body is improved, and the endocrine system is regulated; and through clinical verification, the pills have a good absorbing effect and high cure rate for various glaucoma diseases.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to one and treat glaucomatous pill and preparation method.
Background technology
Glaucoma be a kind ofly fall ill rapidly, hazardness causes blind common difficult oculopathy greatly, at any time, feature is the tolerant degree of horizontal exceeding eyeball institute that intraocular pressure is interrupted or persistence raises and bring infringement to eyeball each several part tissue and visual function, cause optic atrophy, constriction of visual field, visual deterioration, the later stage can cause blind.Glaucomatous etiology and pathogenesis is very complicated, therefore its clinical manifestation is also varied, mainly be divided into four classes according to clinical manifestation: congenital glaucoma, primary glaucoma, secondary glaucoma, mixed glaucoma, according to the form of anterior chamber's anterior angle and morbidity emergency, be divided into again acute and chronic angle closure glaucoma and open angle glaucoma etc.
Acute angle closure glaucoma is conventionally with complication such as nauseating, vomiting, heating, shiver with cold and constipation, and a few patients can have diarrhoea to occur, and chronic angle closure glaucoma is often with looking the complication such as illiteracy, iridization, and the most serious complication of glaucoma is blind.Modern medical service technology, to glaucomatous treatment, adopts therapeutic method of surgery more, as cut iris week such as art, trabeculectomy, valve implanation, goniotomy, angle, room exclusion, cyclocryoapplication, the diathermanous and solidifying art of light etc.Except operative therapy, also have drug treatments such as supplementary choline, pantothenic acid, rutacultin, vitamin B group, vitamin C, vitamin E.These drug treatments have certain clinical effectiveness, but conventionally can not thoroughly cure glaucoma symptom.
Glaucoma is called glaucoma by Traditional Chinese medical theory, thinks that this disease arises from liver pulmonary tuberculosis heat, phlegm-damp merit wound, and namely the liquid regulative mechanism of ophthalmic is not normal, and the eyeball causing because of noxious water closes trouble.In the time of symptomatic treatment, tackle glaucomatous three cardinal symptoms, to shed tears, photophobia, blepharospasm, the prescription that adopts suppressing the hyperactive liver diarrhea of heat type lung qi, strong tonifying liver pulmonary tuberculosis to damage is eliminated noxious water.
Pill of the present invention lay particular emphasis on prescription antioxidation, suppress aldose reductase, provide nutritional labeling directly act on eye with treatment glaucoma, meet the glaucoma pathogenesis that modern medicine study confirms, improve crystalline lens antioxidative functional, eliminate or in and crystalline lens in oxidation product, stop or reverse Lens Biochemistry and change, prevent that lenticular opacity from occurring, activate the each large internal organs of health and activate motive power, keep endocrine equilibrium to coordinate.
Summary of the invention
The invention provides one and treat glaucomatous pill and preparation method, there is suppressing the hyperactive liver profit lung, heat clearing away is eliminated the phlegm, dehumidified and mends effect of damages, the function of the each large internal organs of adjusting health, balanced hormonal system function, all has good curative effect to all kinds of glaucoma illness.
For achieving the above object, technical scheme of the present invention is implemented as follows:
One is treated glaucomatous pill, and raw material composition and the parts by weight of making described pill effective ingredient are:
70～90 parts of 75～95 parts of Spica Prunellaes of 90～120 parts of double hooks of 100～130 parts of Semen Cassiaes of Folium Nelumbinis
50～70 parts of 55～75 portions of Flos Chrysanthemis of 60～80 portions of Rhizoma Alismatis of 65～85 parts of Fructus Leonuris of the Rhizoma Pinelliae
35～50 parts of 35～55 portions of Semen Plantaginiss of 40～60 parts of Rhizoma Ligusticis of 45～65 parts of Concha Margaritiferas of Folium Pyrrosiae
20～35 parts of 25～40 portions of Folium Isatidiss of 30～40 portions of Semen Arecaes of 30～45 parts of Flos Eriocaulis of Radix Scutellariae
5～15 parts of 5～20 parts of Faeces Vespertilioniss of 10～25 parts of Rhizoma Arisaematis of 15～30 parts of Fructus Evodiaes of Rhizoma Cyperi
Raw material composition and the parts by weight of making described pill effective ingredient are:
75～85 parts of 80～90 parts of Spica Prunellaes of 95～115 parts of double hooks of 110～125 parts of Semen Cassiaes of Folium Nelumbinis
55～65 parts of 60～70 portions of Flos Chrysanthemis of 65～75 portions of Rhizoma Alismatis of 70～80 parts of Fructus Leonuris of the Rhizoma Pinelliae
38～46 parts of 40～50 portions of Semen Plantaginiss of 45～55 parts of Rhizoma Ligusticis of 50～60 parts of Concha Margaritiferas of Folium Pyrrosiae
22～32 parts of 28～36 portions of Folium Isatidiss of 32～38 portions of Semen Arecaes of 32～42 parts of Flos Eriocaulis of Radix Scutellariae
6～12 parts of 7～15 parts of Faeces Vespertilioniss of 12～22 parts of Rhizoma Arisaematis of 18～28 parts of Fructus Evodiaes of Rhizoma Cyperi
Raw material composition and the parts by weight of making described pill effective ingredient are:
78～82 parts of 82～88 parts of Spica Prunellaes of 100～110 parts of double hooks of 115～120 parts of Semen Cassiaes of Folium Nelumbinis
58～62 parts of 63～67 portions of Flos Chrysanthemis of 68～72 portions of Rhizoma Alismatis of 73～78 parts of Fructus Leonuris of the Rhizoma Pinelliae
40～44 parts of 42～47 portions of Semen Plantaginiss of 47～53 parts of Rhizoma Ligusticis of 53～57 parts of Concha Margaritiferas of Folium Pyrrosiae
24～28 parts of 30～34 portions of Folium Isatidiss of 34～36 portions of Semen Arecaes of 34～40 parts of Flos Eriocaulis of Radix Scutellariae
8～10 parts of 9～13 parts of Faeces Vespertilioniss of 14～18 parts of Rhizoma Arisaematis of 20～26 parts of Fructus Evodiaes of Rhizoma Cyperi
Raw material composition and the parts by weight of making described pill effective ingredient are:
80 parts of 84 parts of Spica Prunellaes of 102 parts of double hooks of 116 parts of Semen Cassiaes of Folium Nelumbinis
60 parts of 65 portions of Flos Chrysanthemis of 70 portions of Rhizoma Alismatis of 74 parts of Fructus Leonuris of the Rhizoma Pinelliae
42 parts of 44 portions of Semen Plantaginiss of 48 parts of Rhizoma Ligusticis of 54 parts of Concha Margaritiferas of Folium Pyrrosiae
26 parts of 32 portions of Folium Isatidiss of 35 portions of Semen Arecaes of 36 parts of Flos Eriocaulis of Radix Scutellariae
9 parts of 10 parts of Faeces Vespertilioniss of 16 parts of Rhizoma Arisaematis of 22 parts of Fructus Evodiaes of Rhizoma Cyperi
Treat a preparation method for glaucomatous pill, comprise following processing step:
(1) Concha Margaritifera is fired to high heat crisp, pulverizing is ground into powder, crosses 120 order fine powders, for subsequent use.
(2) will after Rhizoma Alismatis, Fructus Evodiae mixing wheat bran, fry to epidermis and be after glassy yellow with slow fire, get Rhizoma Alismatis, Fructus Evodiae is pulverized and ground into powder, crosses 120 order fine powders, for subsequent use.
(3) Folium Nelumbinis, Folium Isatidis are put into container, smash juice, taking juice is for subsequent use.
(4) Semen Plantaginis, Faeces Vespertilionis are wrapped with crocus cloth, put into container with Spica Prunellae, Fructus Leonuri, Flos Chrysanthemi, Folium Pyrrosiae, Rhizoma Ligustici, Radix Scutellariae, Flos Eriocauli, Semen Arecae, add the water of six times of amounts, after heated and boiled, continue to soak after 6～7 hours, get immersion; In remaining medicinal residues, add again the water of four times of amounts, after heated and boiled, continue to soak after 3～4 hours, get immersion; Merge the immersion of twice gained, heating evaporation is the ointment of relative density 1.15～1.20 under room temperature environment, for subsequent use.
(5) Semen Cassiae, double hook, the Rhizoma Pinelliae, Rhizoma Cyperi, Rhizoma Arisaematis are put into container, add the Ji Me Lao Jiu of triplication, soak after 12～16 hours, get immersion; In remaining medicinal residues, add again the Ji Me Lao Jiu of doubling dose, soak after 6～8 hours, get immersion; Merge twice immersion, under simmer down to room temperature environment, the ointment of relative density 1.10～1.15, for subsequent use.
(6) fine powder of step (1), step (2) gained is mixed with the ointment that step (4), step (5) make, the juice that adds refined honey and step (3) to make, is prepared as the pill of every 9g after stirring.
The property of medicine of the present invention's Chinese medicine used is as follows:
Folium Nelumbinis: bitter in the mouth; Cold in nature; Poisonous.Return lung; Stomach; Liver Channel.Inducing vomiting expectorant is glutinous; Preventing the attack (or recurrence) of malaria; Separate skin ulcer pain.Cure mainly malaria; Abdominal pain due to retention of food; Carbuncle furunculosis." detailed outline " carries: " expectorant pathogenic fire reducing, throat, moves back conjunctival congestion." modern medicine study confirmation, Folium Nelumbinis, containing multiple alkaloids such as cycleanine, cepharanthine, left-handed curare alkaloids, has significant leucocytosis effect, also has in addition the effects such as antiinflammatory, removing toxic substances.
Semen Cassiae: salty in the mouth; Bitter; Property is put down; Cool.Nontoxic.Enter liver; Gallbladder; Kidney channel.Expelling wind and clearing away heat; Detoxification and promoting urination.Cure mainly acute conjunctivitis; Jaundice due to damp-heat; Acute and chronic nephritis; Scrofula; Carbuncle sore furuncle and phyma." Japan hanako materia medica " carries: " help irritability, beneficial smart water, detumescence poison, puts temple on the skin and controls headache, pastes the brain heart and stops epistaxis, controls wind syndrome of head, improving eyesight." modern medicine study confirms; the ethanol extract of Semen Cassiae all has resistancing action to staphylococcus, diphtheria corynebacterium, typhoid fever, paratyphoid fever, escherichia coli; to trichophyton gypseum, permitted the fungus such as blue achorion, Du's big belly microspore tinea bacterium difficult to understand and have inhibitory action in various degree; can significantly reduce diastolic pressure; Serum High-Density Lipoprotein-Cholesterol content and HDL-C/TC ratio obviously raise; obviously improve the distribution situation of body inner cholesterol, strengthen immunologic function, protect the liver in addition in addition and discharge function simultaneously.
Double hook: bitter in the mouth; Bitter; Cold nature.Enter liver; Heart channel.Heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind.Cure mainly infantile convulsion; Night cry; Intenseness of heat wind symptom; Eclamposia; Dizziness due to hyperactivity of liver-YANG; Liver-fire distending pain in the head." book on Chinese herbal medicine is stated " carries: " control paralysis due to windstroke, deviation of the eye and mouth, and all brothers' migratory arthralgia caused by wind pain, podomere contraction is anxious.Control again many years ago gout paralysis, the spasm of muscles and vessels endlessly person that has a pain." modern medicine study confirmation; the indoles alkaloid that Ramulus Uncariae Cum Uncis includes, except having blood pressure lowering, antiepileptic action, also has certain angst resistance effect; alcohol extract has obvious depression effect to central nervous system's synapse transmittance process, strengthens the protection to neuronal cell.
Spica Prunellae: bitter in the mouth; Pungent; Cold in nature.Return liver; Gallbladder meridian.Liver heat removing and eyesight improving; Powder detoxifcation.Cure mainly corneal nebula photophobia; Ophthalmalgia; Have a headache dizzy; Tinnitus; Scrofula; Goiter; Acute mastitis; Mumps; Carbuncle furuncle and phyma poison; Acute, chronic hepatitis; Hypertension." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " liver-wind of dispelling, the network of passing through.Control facial hemiparalysis, row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, loose scrofula, whole body tuberculosis." modern medicine study confirmation, Spica Prunellae has significant blood pressure lowering and antibacterial action.
The Rhizoma Pinelliae: property is pungent, warm, is slightly cold, ripe temperature.Enter spleen, stomach warp.Drying dampness to eliminate phlegm, sending down the abnormal ascending QI preventing or arresting vomitting, dissolving lump and resolving mass, outer subduing inflammation." not Lu " carries: " subduing inflammation, treat sallow, happy damp appearance ".Modern medicine study confirmation, the Rhizoma Pinelliae has significant antitussive effect, can suppress the secretion of body of gland, suppresses tryptic hydrolysis, also has in addition blood pressure lowering, blood coagulation, the fissional effect of promotion.
Fructus Leonuri: sweet in the mouth; Pungent.Cold nature; Upper poison.Return Liver Channel.Promoting blood flow to regulate menstruation; Liver heat removing and eyesight improving.Cure mainly menoxenia; Dysmenorrhea; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Liver-heat headache; Dizzy; Conjunctival congestion and swelling pain; The raw cataracta of order." Bencao Jingshu " carries: " large heat headache is vexed, all the time of blood deficiency and heat also, liver heat removing heat radiation and blood, the vexed all solutions of having a headache." modern medicine study confirmation, Fructus Leonuri, containing leonurinine alkali, stachydrine, fatty oil, 17 seed amino acids and 24 kinds of mineral elements, has slight hypotensive effect, and central nervous system is had to the effect of inhibition paralysis.
Rhizoma Alismatis: sweet in the mouth; Light.Cold in nature.Return kidney; Urinary bladder channel.Promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Cure mainly dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission." not Lu " carries: " tonifying deficiency five kinds of over strain, except the five internal organs feeling of fullness, plays cloudy gas, stopping leak essence, quenches one's thirst, drenches drop, cuts off the water by bladder, three warmers." modern medicine study confirmation, Rhizoma Alismatis has the cholesterol of reduction and comforts Atherosclerosis, improves liver lipid metabolism, and blood sugar lowering, blood pressure, affect function of immune system, and serum hemolysin is reduced.
Flos Chrysanthemi: bitter in the mouth; Pungent; Property is put down.Enter lung; Liver Channel.Heat-clearing and toxic substances removing; Dispelling wind suppressing the hyperactive liver.Cure mainly furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Anemopyretic cold; Laryngopharynx swelling and pain; Hypertension." book on Chinese herbal medicine converges and says " carries: " removing blood stasis is soothing the liver; Separate the loose poison of furuncle.Stagnated blood in housewife people's abdomen, the red furuncle of the capable fire-toxin of Xie Tian.Wash skin ulcer scabies, can remove again wind parasite killing.”
Folium Pyrrosiae: sweet in the mouth; Bitter; Property is put down; Be slightly cold.Enter lung; Urinary bladder channel.Relieving stranguria by diuresis; Lung heat clearing expels the heat-evil; Cure mainly and drench pain; Hematuria; Lithangiuria; Nephritis; Metrorrhagia; Dysentery; Cough due to lung-heat; Chronic tracheitis; Incised wound; Carbuncle." detailed outline " carries: " main metrorrhagia, incised wound, lung heat clearing gas." modern medicine study confirmation, Folium Pyrrosiae has inhibitory action in various degree to staphylococcus aureus, Bacillus proteus, escherichia coli, and resisiting influenza virus effectively promotes quantity of leucocyte, is applicable to treat pyretic stranguria more, has effect of clearing away heat to stop bleeding.
Concha Margaritifera: salty in the mouth; Cold in nature.Return liver; Heart channel.Suppressing the hyperactive liver and subsiding YANG; The arresting convulsion of calming the nerves; Liver heat removing and eyesight improving.Cure mainly suppressing the hyperactive liver; YANG hyperactivity suppressing; Arresting convulsion; Hemostasis; Dizziness; Tinnitus; Cardiopalmus; Insomnia; Demented; Infantile convulsion; Spit blood; Epistaxis; Metrorrhagia." Chinese medicine voluminous dictionary " carry: " liver nourishing the moon, clearing away liver-fire are controlled demented infantile convulsion, double enter the heart, liver two warps, relate to mind patient, this.”
Rhizoma Ligustici: acrid in the mouth; Warm in nature.Return urinary bladder channel.Dispel the wind; Cold expelling; Dehumidifying; Pain relieving.Cure mainly anemofrigid cold; Top, mountain peak pain; Rheumatism podomere arthralgia pain." Bencao Jingshu " carries: " epidemic febrile disease headache, the thirsty or bone pain of generating heat, and typhoid fever sends out in spring and summer, and YANG syndrome headache, the scorching headache of blood deficiency fire in puerperal, neither should take." modern medicine study confirms, Rhizoma Ligustici can suppress motion excitement, raising capillary permeability, and contained this lactone of Rhizoma Ligustici has calmness, hypnosis, cooling and anti-ketamine excitation, the effect such as suppress in addition in addition smooth muscle, relieving asthma.
Semen Plantaginis: sweet in the mouth; Light; Cold nature.Return lung; Liver; Kidney; Urinary bladder channel.Clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; Eliminate the phlegm.Cure mainly dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough is breathed heavily." Japan hanako materia medica " carries: " diuresis drenches puckery, tonifying YANG.Control de-essence, vexed, the therapeutic method to keep the adverse QI flowing downwards." modern medicine study confirmation, Semen Plantaginis has remarkable diuresis, can also promote respiratory mucus secretion, dilution sputum, and various bacillus and staphylococcus are had to remarkable inhibitory action.
Radix Scutellariae: acrid in the mouth; Bitter; Cold in nature.Return lung; Liver; Kidney channel.Heat-clearing and toxic substances removing; Dissipating blood stasis hemostasis; Inducing diuresis to remove edema.Cure mainly pyretic toxicity carbuncle; Have sore throat; Lung abscess; Intestinal carbuncle; Scrofula; Venom; Traumatic injury; Spit blood; Epistaxis; Stranguria with blood; Edema; Ascites and cancer." Quanzhou book on Chinese herbal medicine " carries: " heat clearing away, removing toxic substances, method wind, loose blood, circulation of qi promoting, diuretic, dredging collateral, removing blood stasis with potent drugs, pain relieving.Main stranguria with blood for oral administration, spits blood, epistaxis; External smelting venom, carbuncle, furuncle, innominate toxic swelling." modern medicine study confirmation, Radix Scutellariae has broad-spectrum antibacterial action, also has in addition the effect of antiplatelet aggregation, anticoagulant and blood fat reducing.
Flos Eriocauli: acrid in the mouth; Sweet; Cool in nature.Enter stomach; Lung meridian.Wind and heat eliminating; Improving acuity of vision and removing nebula.Cure mainly conjunctival congestion cataracta; Photophobia is shed tears; Nyctalopia; Headache; Nasal sinusitis; Sore throat; Toothache and rubella pruritus." Xinhua's book on Chinese herbal medicine outline " carries: " have improving acuity of vision and removing nebula, pain-relieving functions." modern medicine study confirmation; Flos Eriocauli water logging agent all has inhibitory action in various degree to Microsporon audouini, rust microspore's tinea bacterium etc.; water logging agent is effective to funguses such as acrothesium floccosum, ulotrichy microspore's tinea bacterium, sycosis tinea bacterium, Gypsum Fibrosum sample microspore tinea bacterium, and bacillus pyocyaneus is had to stronger antibacterial action.
Semen Arecae: bitter in the mouth; Pungent; Warm in nature.Enter stomach; Large intestine channel.Anthelmintic; Removing food stagnancy; The therapeutic method to keep the adverse QI flowing downwards; Row water; Preventing the attack (or recurrence) of malaria.Cure mainly malnutrition due to parasitic infestation; Dyspepsia; Abdominal distention; Heavy after dysentery; Foot gas; Edema; Malaria." book on Chinese herbal medicine converges and says " carries: " cure mainly all gas, the miasma of dispelling, broken stagnant gas, dissipating depression of QI gas, lower mental disorder, removes pneumatosis, touches legendary venomous insect gas, rapid digestion of food gas, discharging the water pathogen, loose beriberi, parasite killing gas, leads to upper gas, alleviating distention in middle-JIAO gas, the medicine of diarrhea gas is also." modern medicine study confirmation, the nutrient that Semen Arecae contains multiple needed by human body and benefit materials, as compositions such as fat, betel oil, alkaloid, catechin, choline, have unique imperial miasma function in addition.
Folium Isatidis: bitter in the mouth; Cold in nature.Enter liver; The heart; Stomach; Spleen channel.Heat-clearing and toxic substances removing; Blood cooling and ecchymoses removing.Cure mainly the high hot excessive thirst of calentura; Coma; Macule; Spit blood; Epistaxis; Jaundice; Dysentery; Erysipelas; Sore throat; Aphtha; Mumps." Bencao Jingshu " carries: " Folium Isatidis can go large heat, controls pestilence cold and heat.Lid is double bitter Great Cold, and it is bright that it can dismiss tooth pathogenic heat." modern medicine study confirmation, Folium Isatidis has antibacterial action widely, can obviously increase bile secretion, has obvious antiinflammatory action, strengthens the phagocytosis of leukocyte to antibacterial, and blood vessel dilating and smooth muscle, also have antibacterial and antiplatelet aggregative activity in addition.
Rhizoma Cyperi: acrid in the mouth; Cold nature; Nontoxic.Return liver; Lung; Spleen; Stomach; Tri-jiao channel.The resolving depression of regulating the flow of vital energy; Menstruction regulating and pain relieving.Cure mainly distending pain over the hypochondrium; Hernia pain; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation; Vomiting and nausea; Bleeding not during menses." detailed outline " carries: " the cold epidemic disease of loose seasonal epidemic pathogens, sharp three warmers, Xie Nvyu, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia." modern medicine study proves, Rhizoma Cyperi has nervous system regulation effect, and has heart tonifying, decreased heart rate, reduces blood pressure, prevents and treats the effect such as hyperlipemia and atherosclerosis.
Fructus Evodiae: acrid in the mouth; Bitter; Hot in nature; Mild toxicity.Enter liver; Stomach; Spleen; Large intestine; Kidney channel.Dispersing cold for relieving pain; The soothing the liver therapeutic method to keep the adverse QI flowing downwards; Warming middle-JIAO dampness.Cure mainly coldness and pain in the epigastrium; Headache due to JUE YIN disorder; Colic; Beriberi swells and ache; Vomiting acid regurgitation; Cold-damp is had loose bowels.Compendium of Material Medica is carried: " dissipating depression of QIization is stagnant.Control acid regurgitation, the cloudy sputum headache of fainting, insidious stomachache, hernia, dysentery, mouthpiece's mouth is choked." modern medicine study confirmation, Fructus Evodiae has town to tell, antidiarrheal, and antiulcer, suppresses stomach motion, and heart tonifying, rises blood pressure, and shock improves microcirculation, improves the effects such as immunologic function.
Rhizoma Arisaematis: bitter in the mouth; Pungent; Warm in nature; Poisonous.Enter lung; Liver; Spleen channel.Expelling wind and relieving convulsion; Dissipating phlegm and resolving masses.Curing mainly middle wind-phlegm stops up; Mouth eye is askew arbitrarily; Hemiplegia; Paralysis of the limbs; Dizziness due to wind-phlegm; The insane spare time; Infantile convulsion; Tetanus; Cough ant phlegm; Carbuncle; Scrofula; Traumatic injury paralysis; Venom." herbal classic " carries: " main pained, cold and heat, stagnation of QI, gathers, fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times, flaccidity, arrests and delays, dredging water passages." modern medicine study confirmation; Rhizoma Arisaematis contains triterpenoid saponin; benzoic acid; starch; the several amino acids such as PEARLITOL 25C and ornithine, glutamic acid, leucine, aspartic acid; have obvious anticonvulsant action, and the multiple transplanted tumors such as pulmonary carcinoma, hepatocarcinoma, ehrlich carcinoma are are all killed and wounded and inhibitory action.
Faeces Vespertilionis: acrid in the mouth; Cold in nature.Enter Liver Channel.Liver heat removing and eyesight improving; Dissipating blood stasis removing food stagnancy.Cure mainly optic atrohic blindness; Nyctalopia; Conjunctival congestion and swelling pain; Subconjuctival hemorrhage; Inside and outside cataracta; Infantile malnutrition; Scrofula; Malaria." Bencao Jingshu " carries: " except QI and blood in abdomen, broken cold and heat gather, and except palpitation with fear, get the loose inside and outside knot of its pungent energy stagnant, can stop up also by dehematize steam therefore cold." modern medicine study confirmation, Faeces Vespertilionis, containing carbamide, uric acid, cholesterol and a small amount of vitamin A, has the circulation of the ocular blood of improvement, the nutrition of increase optic nerve, the effects such as promotion ocular tissue metabolism.
The present invention compared with prior art, has following beneficial effect:
Prescription of the present invention is superior, for the mechanism that causes glaucomatous liver pulmonary tuberculosis heat, phlegm-damp merit wound, the medicine of the liver-heat profit of making even lung qi is monarch, getting heat clearing away expectorant is minister, mend damage medicine taking dehumidifying and make as a left side, improve the oxidation resistance of body, endocrine regulation system, through clinical verification good absorbing effect, all kinds of glaucoma illness are all had to higher cure rate.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the weight of pill effective ingredient of the present invention are:
Folium Nelumbinis 125g Semen Cassiae 110g double hook 90g Spica Prunellae 85g
Rhizoma Pinelliae 80g Fructus Leonuri 75g Rhizoma Alismatis 70g Flos Chrysanthemi 66g
Folium Pyrrosiae 60g Concha Margaritifera 55g Rhizoma Ligustici 50g Semen Plantaginis 47g
Radix Scutellariae 42g Flos Eriocauli 38g Semen Arecae 35g Folium Isatidis 33g
Rhizoma Cyperi 28g Fructus Evodiae 20g Rhizoma Arisaematis 15g Faeces Vespertilionis 14g
The processing step of pill preparation method of the present invention is:
(1) Concha Margaritifera is fired to high heat crisp, pulverizing is ground into powder, crosses 120 order fine powders, for subsequent use.
(2) will after Rhizoma Alismatis, Fructus Evodiae mixing wheat bran, fry to epidermis and be after glassy yellow with slow fire, get Rhizoma Alismatis, Fructus Evodiae is pulverized and ground into powder, crosses 120 order fine powders, for subsequent use.
(3) Folium Nelumbinis, Folium Isatidis are put into container, smash juice, taking juice is for subsequent use.
(4) Semen Plantaginis, Faeces Vespertilionis are wrapped with crocus cloth, put into container with Spica Prunellae, Fructus Leonuri, Flos Chrysanthemi, Folium Pyrrosiae, Rhizoma Ligustici, Radix Scutellariae, Flos Eriocauli, Semen Arecae, add the water of six times of amounts, after heated and boiled, continue to soak after 6～7 hours, get immersion; In remaining medicinal residues, add again the water of four times of amounts, after heated and boiled, continue to soak after 3～4 hours, get immersion; Merge the immersion of twice gained, heating evaporation is the ointment of relative density 1.15～1.20 under room temperature environment, for subsequent use.
(5) Semen Cassiae, double hook, the Rhizoma Pinelliae, Rhizoma Cyperi, Rhizoma Arisaematis are put into container, add the Ji Me Lao Jiu of triplication, soak after 12～16 hours, get immersion; In remaining medicinal residues, add again the Ji Me Lao Jiu of doubling dose, soak after 6～8 hours, get immersion; Merge twice immersion, under simmer down to room temperature environment, the ointment of relative density 1.10～1.15, for subsequent use.
(6) fine powder of step (1), step (2) gained is mixed with the ointment that step (4), step (5) make, the juice that adds refined honey and step (3) to make, is prepared as the pill of every 9g after stirring.
Usage and dosage: oral, adult every day 3 each 1 balls, acute glaucoma patient's every day 4 each 1.5 balls, perform a surgical operation treatment after 2 each 1 balls every day in recovery stage, within one hour after meal, take with warm water or warm yellow wine, within 3 days, be a course for the treatment of.
Embodiment 2
Raw material composition and the weight of pill effective ingredient of the present invention are:
Folium Nelumbinis 120g Semen Cassiae 108g double hook 88g Spica Prunellae 84g
Rhizoma Pinelliae 78g Fructus Leonuri 73g Rhizoma Alismatis 68g Flos Chrysanthemi 64g
Folium Pyrrosiae 58g Concha Margaritifera 53g Rhizoma Ligustici 48g Semen Plantaginis 45g
Radix Scutellariae 40g Flos Eriocauli 37g Semen Arecae 34g Folium Isatidis 30g
Rhizoma Cyperi 26g Fructus Evodiae 18g Rhizoma Arisaematis 13g Faeces Vespertilionis 12g
Pill preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
Raw material composition and the parts by weight of pill effective ingredient of the present invention are:
Folium Nelumbinis 118g Semen Cassiae 105g double hook 86g Spica Prunellae 82g
Rhizoma Pinelliae 76g Fructus Leonuri 71g Rhizoma Alismatis 66g Flos Chrysanthemi 62g
Folium Pyrrosiae 55g Concha Margaritifera 51g Rhizoma Ligustici 45g Semen Plantaginis 43g
Radix Scutellariae 38g Flos Eriocauli 36g Semen Arecae 33g Folium Isatidis 28g
Rhizoma Cyperi 24g Fructus Evodiae 17g Rhizoma Arisaematis 12g Faeces Vespertilionis 10g
Pill preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
Raw material composition and the parts by weight of pill effective ingredient of the present invention are:
Folium Nelumbinis 116g Semen Cassiae 102g double hook 84g Spica Prunellae 80g
Rhizoma Pinelliae 74g Fructus Leonuri 70g Rhizoma Alismatis 65g Flos Chrysanthemi 60g
Folium Pyrrosiae 54g Concha Margaritifera 48g Rhizoma Ligustici 44g Semen Plantaginis 42g
Radix Scutellariae 36g Flos Eriocauli 35g Semen Arecae 32g Folium Isatidis 26g
Rhizoma Cyperi 22g Fructus Evodiae 16g Rhizoma Arisaematis 10g Faeces Vespertilionis 9g
Pill preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection
The routine clinical observation of glaucoma disease patient 31 of selecting my institute or outer court to make a definite diagnosis, patient is divided into two groups at random.Treatment group 16 examples, wherein male's 9 examples, women's 7 examples, 29～57 years old age, 46.7 years old mean age, the shortest person of the course of disease 2 months, elder 9 years, average 3.8 years.Matched group 15 examples, wherein male's 7 examples, women's 8 examples, 31～54 years old age, 48.4 years old mean age, the shortest person of the course of disease 3 months, elder 12 years, average 5.4 years.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.
2, treatment group patient takes pill of the present invention, and adult every day 3 times, each oral 1 ball, 3 days is a course for the treatment of.Instil at regular time and quantity choline, pantothenic acid, vitamin B, vitamin C, vitamin Es etc. of matched group apply treatment.
3, efficacy determination:
(1) effective: the classical symptoms such as head severe pain, eyeball congestion, vision rapid drawdown, iridization are significantly alleviated or disappeared, and intraocular pressure reduces, feel sick, the complication such as vomiting, perspiration obviously alleviates or disappear.
(2) take a turn for the better: all kinds of classical symptoms of glaucoma and and all alleviations to some extent of symptom disease.
(3) invalid: symptom is with treating front no significant difference.
4, result
In treatment group, cure 12 examples, 3 examples that take a turn for the better, invalid 1 example, cure rate 75%, total effective rate 93.8%.
In matched group, cure 3 examples, 4 examples that take a turn for the better, invalid 8 examples, cure rate 20%, total effective rate 46.7%.
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is given an example:
1, grandson × ×, man, 35 years old, office staff.This patient in JIUYUE, 2010 finds to suffer from open angle glaucoma in Yantai Yuhuangding Hospital, after use collyrium to reduce intraocular pressure always, use intraocular pressure after three months not fall, rear employing laser therapy effect is still undesirable.After to our hospital, follow the doctor's advice and take after 2 courses for the treatment of of pill of the present invention, intraocular pressure significantly decreases, and pain symptom has also had significant alleviation, and defect of visual field has stopped development at present, feels sick, the syndrome such as vomiting disappears.
2, sternly × ×, female, 48 years old, secondary school teachers.Two eyes of patient have cataract and glaucomatous symptom, and wherein eyes have not seen Chu Dongxi, successively take the medicine of multiple relief of symptoms, adhere to that the later stage was done laser therapy with collyrium, and symptom continues to increase the weight of.Through my institute's diagnosis, its glaucoma symptom is very serious, arranges it to carry out operative treatment, takes pill of the present invention in post-operative recovery process, and after 1 course for the treatment of, readme recovery effects is good, at present still in medication treatment.
3, hole × ×, man, 32 years old, bank clerk.Patient's readme left eye eyeball has sensation of dryness, and blurred vision eyeball surface is as there being a layer gum sometimes, and sensation rises a little but can not calculate pain, has once in a while black eye ball side internal hemorrhage, particularly drink or stay up late after easily occur.After to our hospital, through optic nerve morphological examination, have slight optic nerve injury symptom, take after 1 course for the treatment of of pill of the present invention, statement symptom all disappears.
Claims (5)
1. the glaucomatous pill for the treatment of, is characterized in that: raw material composition and the parts by weight of making described pill effective ingredient are:
70～90 parts of 75～95 parts of Spica Prunellaes of 90～120 parts of double hooks of 100～130 parts of Semen Cassiaes of Folium Nelumbinis
50～70 parts of 55～75 portions of Flos Chrysanthemis of 60～80 portions of Rhizoma Alismatis of 65～85 parts of Fructus Leonuris of the Rhizoma Pinelliae
35～50 parts of 35～55 portions of Semen Plantaginiss of 40～60 parts of Rhizoma Ligusticis of 45～65 parts of Concha Margaritiferas of Folium Pyrrosiae
20～35 parts of 25～40 portions of Folium Isatidiss of 30～40 portions of Semen Arecaes of 30～45 parts of Flos Eriocaulis of Radix Scutellariae
5～15 parts of 5～20 parts of Faeces Vespertilioniss of 10～25 parts of Rhizoma Arisaematis of 15～30 parts of Fructus Evodiaes of Rhizoma Cyperi; The preparation method of making described pill comprises following processing step:
(1) Concha Margaritifera is fired to high heat crisp, pulverizing is ground into powder, crosses 120 order fine powders, for subsequent use;
(2) will after Rhizoma Alismatis, Fructus Evodiae mixing wheat bran, fry to epidermis and be after glassy yellow with slow fire, get Rhizoma Alismatis, Fructus Evodiae is pulverized and ground into powder, crosses 120 order fine powders, for subsequent use;
(3) Folium Nelumbinis, Folium Isatidis are put into container, smash juice, taking juice is for subsequent use;
(4) Semen Plantaginis, Faeces Vespertilionis are wrapped with crocus cloth, put into container with Spica Prunellae, Fructus Leonuri, Flos Chrysanthemi, Folium Pyrrosiae, Rhizoma Ligustici, Radix Scutellariae, Flos Eriocauli, Semen Arecae, add the water of six times of amounts, after heated and boiled, continue to soak after 6～7 hours, get immersion; In remaining medicinal residues, add again the water of four times of amounts, after heated and boiled, continue to soak after 3～4 hours, get immersion; Merge the immersion of twice gained, heating evaporation is the ointment of relative density 1.15～1.20 under room temperature environment, for subsequent use;
(5) Semen Cassiae, double hook, the Rhizoma Pinelliae, Rhizoma Cyperi, Rhizoma Arisaematis are put into container, add the Ji Me Lao Jiu of triplication, soak after 12～16 hours, get immersion; In remaining medicinal residues, add again the Ji Me Lao Jiu of doubling dose, soak after 6～8 hours, get immersion; Merge twice immersion, under simmer down to room temperature environment, the ointment of relative density 1.10～1.15, for subsequent use;
(6) fine powder of step (1), step (2) gained is mixed with the ointment that step (4), step (5) make, the juice that adds refined honey and step (3) to make, is prepared as the pill of every 9g after stirring.
2. one according to claim 1 is treated glaucomatous pill, it is characterized in that: raw material composition and the parts by weight of making described pill effective ingredient are:
75～85 parts of 80～90 parts of Spica Prunellaes of 95～115 parts of double hooks of 110～125 parts of Semen Cassiaes of Folium Nelumbinis
55～65 parts of 60～70 portions of Flos Chrysanthemis of 65～75 portions of Rhizoma Alismatis of 70～80 parts of Fructus Leonuris of the Rhizoma Pinelliae
38～46 parts of 40～50 portions of Semen Plantaginiss of 45～55 parts of Rhizoma Ligusticis of 50～60 parts of Concha Margaritiferas of Folium Pyrrosiae
22～32 parts of 28～36 portions of Folium Isatidiss of 32～38 portions of Semen Arecaes of 32～42 parts of Flos Eriocaulis of Radix Scutellariae
6～12 parts of 7～15 parts of Faeces Vespertilioniss of 12～22 parts of Rhizoma Arisaematis of 18～28 parts of Fructus Evodiaes of Rhizoma Cyperi.
3. one according to claim 1 is treated glaucomatous pill, it is characterized in that: raw material composition and the parts by weight of making described pill effective ingredient are:
78～82 parts of 82～88 parts of Spica Prunellaes of 100～110 parts of double hooks of 115～120 parts of Semen Cassiaes of Folium Nelumbinis
58～62 parts of 63～67 portions of Flos Chrysanthemis of 68～72 portions of Rhizoma Alismatis of 73～78 parts of Fructus Leonuris of the Rhizoma Pinelliae
40～44 parts of 42～47 portions of Semen Plantaginiss of 47～53 parts of Rhizoma Ligusticis of 53～57 parts of Concha Margaritiferas of Folium Pyrrosiae
24～28 parts of 30～34 portions of Folium Isatidiss of 34～36 portions of Semen Arecaes of 34～40 parts of Flos Eriocaulis of Radix Scutellariae
8～10 parts of 9～13 parts of Faeces Vespertilioniss of 14～18 parts of Rhizoma Arisaematis of 20～26 parts of Fructus Evodiaes of Rhizoma Cyperi.
4. one according to claim 1 is treated glaucomatous pill, it is characterized in that: raw material composition and the parts by weight of making described pill effective ingredient are:
80 parts of 84 parts of Spica Prunellaes of 102 parts of double hooks of 116 parts of Semen Cassiaes of Folium Nelumbinis
60 parts of 65 portions of Flos Chrysanthemis of 70 portions of Rhizoma Alismatis of 74 parts of Fructus Leonuris of the Rhizoma Pinelliae
42 parts of 44 portions of Semen Plantaginiss of 48 parts of Rhizoma Ligusticis of 54 parts of Concha Margaritiferas of Folium Pyrrosiae
26 parts of 32 portions of Folium Isatidiss of 35 portions of Semen Arecaes of 36 parts of Flos Eriocaulis of Radix Scutellariae
9 parts of 10 parts of Faeces Vespertilioniss of 16 parts of Rhizoma Arisaematis of 22 parts of Fructus Evodiaes of Rhizoma Cyperi.
5. a preparation method for the treatment of glaucomatous pill as described in claim 1-4 any one, is characterized in that: comprise following processing step:
(1) Concha Margaritifera is fired to high heat crisp, pulverizing is ground into powder, crosses 120 order fine powders, for subsequent use;
(2) will after Rhizoma Alismatis, Fructus Evodiae mixing wheat bran, fry to epidermis and be after glassy yellow with slow fire, get Rhizoma Alismatis, Fructus Evodiae is pulverized and ground into powder, crosses 120 order fine powders, for subsequent use;
(3) Folium Nelumbinis, Folium Isatidis are put into container, smash juice, taking juice is for subsequent use;
(4) Semen Plantaginis, Faeces Vespertilionis are wrapped with crocus cloth, put into container with Spica Prunellae, Fructus Leonuri, Flos Chrysanthemi, Folium Pyrrosiae, Rhizoma Ligustici, Radix Scutellariae, Flos Eriocauli, Semen Arecae, add the water of six times of amounts, after heated and boiled, continue to soak after 6～7 hours, get immersion; In remaining medicinal residues, add again the water of four times of amounts, after heated and boiled, continue to soak after 3～4 hours, get immersion; Merge the immersion of twice gained, heating evaporation is the ointment of relative density 1.15～1.20 under room temperature environment, for subsequent use;
(5) Semen Cassiae, double hook, the Rhizoma Pinelliae, Rhizoma Cyperi, Rhizoma Arisaematis are put into container, add the Ji Me Lao Jiu of triplication, soak after 12～16 hours, get immersion; In remaining medicinal residues, add again the Ji Me Lao Jiu of doubling dose, soak after 6～8 hours, get immersion; Merge twice immersion, under simmer down to room temperature environment, the ointment of relative density 1.10～1.15, for subsequent use;
(6) fine powder of step (1), step (2) gained is mixed with the ointment that step (4), step (5) make, the juice that adds refined honey and step (3) to make, is prepared as the pill of every 9g after stirring.
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| CN201210510703.XA CN102940753B (en) | 2012-12-04 | 2012-12-04 | Pills for treating glaucoma and preparation method |
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| CN201210510703.XA CN102940753B (en) | 2012-12-04 | 2012-12-04 | Pills for treating glaucoma and preparation method |
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| CN104825953A (en) * | 2015-04-15 | 2015-08-12 | 青岛辰达生物科技有限公司 | Traditional Chinese medicinal composition for improving intraocular pressure controlled glaucoma vision function |
| CN105362631A (en) * | 2015-12-17 | 2016-03-02 | 夏修菲 | Traditional Chinese medicine pill used for treating bronchial asthma and preparation method |
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| CN1055399C (en) * | 1995-02-25 | 2000-08-16 | 王存民 | Acupoint application for myopia |
| CN1453019A (en) * | 2003-05-21 | 2003-11-05 | 西安碑林药业股份有限公司 | Chinese medicine for treating eye diseases of middle-aged and old people and its prepn |
| CN101121012B (en) * | 2007-08-08 | 2010-05-19 | 李金山 | Traditional Chinese medicine for treating external oculopathy eye disease |
| CN102188584A (en) * | 2011-04-22 | 2011-09-21 | 姜斌 | Traditional Chinese medicine composition for treating glaucoma |
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