Summary of the invention
The invention provides a kind of pill for retrobulbar neuritis disease and preparation method, have nourishing blood to expel wind, heat radiation nebula removing, the circulation of dredging ocular blood, increase optic nerve nutrition, promote the metabolic function of ocular tissue, retrobulbar neuritis disease is had good curative effect.
For achieving the above object, technical scheme of the present invention is implemented as follows:
A kind of pill for retrobulbar neuritis disease, raw material composition and the parts by weight of making described pill effective ingredient are:
37~54 parts of 40~57 parts of Cortex Moutans of 42~60 parts of Rhizomadioscoreae of 45~63 parts of Radix Angelicae Sinensis of Radix Glycyrrhizae
27~43 parts of 29~45 parts of Rhizoma Chuanxiongs of 32~48 parts of Fructus Ligustri Lucidi of 35~51 portions of Rhizoma Alismatis of Ramulus Cinnamomi
16~24 parts of 19~28 parts of Radix Saposhnikoviaes of 22~30 parts of Fructus Leonuris of 25~31 parts of Poria of Periostracum cicadae
6~13 parts of 9~17 parts of Faeces Vespertilioniss of 12~20 parts of Herba Strobilanthis Japonici of 14~23 parts of Radix Codonopsis of Fructus Lycii
Raw material composition and the parts by weight of making described pill effective ingredient are:
39~53 parts of 41~54 parts of Cortex Moutans of 43~58 parts of Rhizomadioscoreae of 47~60 parts of Radix Angelicae Sinensis of Radix Glycyrrhizae
28~41 parts of 31~43 parts of Rhizoma Chuanxiongs of 34~45 parts of Fructus Ligustri Lucidi of 36~49 portions of Rhizoma Alismatis of Ramulus Cinnamomi
18~22 parts of 20~27 parts of Radix Saposhnikoviaes of 25~29 parts of Fructus Leonuris of 26~30 parts of Poria of Periostracum cicadae
8~12 parts of 11~16 parts of Faeces Vespertilioniss of 14~19 parts of Herba Strobilanthis Japonici of 16~22 parts of Radix Codonopsis of Fructus Lycii
Raw material composition and the parts by weight of making described pill effective ingredient are:
42 parts of 44 parts of Cortex Moutans of 49 parts of Rhizomadioscoreae of 51 parts of Radix Angelicae Sinensis of Radix Glycyrrhizae
31 parts of 34 parts of Rhizoma Chuanxiongs of 36 parts of Fructus Ligustri Lucidi of 39 portions of Rhizoma Alismatis of Ramulus Cinnamomi
20 parts of 22 parts of Radix Saposhnikoviaes of 26 parts of Fructus Leonuris of 27 parts of Poria of Periostracum cicadae
9 parts of 12 parts of Faeces Vespertilioniss of 17 parts of Herba Strobilanthis Japonici of 19 parts of Radix Codonopsis of Fructus Lycii
A kind of preparation method of the pill for retrobulbar neuritis disease comprises following processing step:
(1) Radix Angelicae Sinensis, Periostracum cicadae are ground into powder after pulverizing, crossed 200 order fine powders, for subsequent use.
(2) Rhizomadioscoreae, Fructus Lycii are put into container, smash as medicine mud, for subsequent use.
(3) with Herba Strobilanthis Japonici enriching brown sugar water, after the slow fire fried dry, grind into powder, cross 120 order fine powders, for subsequent use.
(4) Rhizoma Alismatis is stir-fried for several times with slow fire, even with the wine spray, fried dry is ground into powder, crosses 120 order fine powders, and is for subsequent use.
(5) Faeces Vespertilionis is wrapped with crocus cloth, put into container with Radix Glycyrrhizae, Cortex Moutan, Ramulus Cinnamomi, Fructus Ligustri Lucidi, Fructus Leonuri, Radix Saposhnikoviae, add the water of six times of amounts, soak after 6~7 hours, get immersion; The water that adds again four times of amounts in remaining medicinal residues soaked after 4~5 hours, got immersion; Merge twice gained immersion, the thick paste of relative density 1.15~1.20 is for subsequent use under 70 ℃ of environment of simmer down to.
(6) Rhizoma Chuanxiong, Poria, Radix Codonopsis are put into container, add the yellow wine of six times of amounts, boil rear immersion 2~3 hours, get and boil liquid; The yellow wine that adds again triplication in remaining medicinal residues soaked under the room temperature 2~3 hours, got and boiled liquid; Merge twice gained and boil liquid, the thick paste of relative density 1.10~1.15 is for subsequent use under the simmer down to room temperature environment.
(7) fine powder of step (1), step (3), step (4) gained, the medicine mud of step (2) gained are mixed with the thick paste of step (5), step (6) gained, the rear adding Mel that stirs is prepared as the pill of 9g/ grain.
The property of medicine of the used Chinese medicine of the present invention is as follows:
Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; The stomach warp.Refreshing spleen QI invigorating; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity.Compendium of Material Medica is carried: " Radix Glycyrrhizae is monarch in all medicines.Control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine meritorious." the modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; be widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, also have anti-gastric-ulcer, gastritis effect.
Radix Angelicae Sinensis: warm in nature, sweet in the mouth, suffering; Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation is used for blood deficiency and yellow complexion, dizzy cardiopalmus, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores.Carry according to " book on Chinese herbal medicine is just ": " its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable." modern medicine study confirms, antibiotic, antiinflammation that Radix Angelicae Sinensis has, the Radix Angelicae Sinensis hot water extract has obvious inhibitory action during to the acute attack of chronic rheumatoid arthritis.
Rhizomadioscoreae: sweet in the mouth; Property is put down.Enter spleen; Lung; Kidney channel.The spleen reinforcing nourishing the stomach; Lung benefiting promotes the production of body fluid; The kidney invigorating arresting seminal emission.Cure mainly insufficiency of the spleen lack of appetite; Incessant chronic diarrhea; The deficiency of the lung is breathed with cough; Deficiency-heat is quenched one's thirst.Compendium of Material Medica is carried: " strengthening the spleen and tonifying the lung, long will is calmed the nerves, and controls that lassitude, inappetence, insufficiency of lung-QI are dry, kidney qi loss etc." modern medicine study shows; Rhizomadioscoreae is rich in 18 seed amino acids and more than 10 plants trace element and other mineral; can prevent and treat the unusual and arteriosclerosis of Human Lipid Metabolism; to safeguarding the insulin normal function certain effect is arranged also, the body immunity of enhancing, beneficial heart and tranquilizing mind is arranged, rather cough the effects such as Dingchuan, slow down aging.
Cortex Moutan: acrid in the mouth; Bitter; Cool in nature; Be slightly cold.Enter the heart; Liver; Kidney; Lung meridian.Heat clearing away; Blood circulation promoting and blood stasis dispelling.Cure mainly the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; Virus hot Fu Yin of later stage brimful of tears divides heating; Deficiency of YIN osteopyrexia and fever; Carbuncle sore tumefacting virus; The rheumatism pyretic arthralgia.Shennong's Herbal carries: " except the hard blood stasis of disease stays the house the intestines and stomach, settling five organs is treated the carbuncle skin ulcer for main cold and heat, apoplexy clonic convulsion, convulsion, infantile convulsion pathogen.Modern medicine study confirms, the effects such as that Cortex Moutan has is analgesic, antiinflammatory, antiallergic action effectively strengthen the immunologic function of body fluid and cell, and platelet aggregation is had obvious resistancing action.
Ramulus Cinnamomi: acrid in the mouth; Sweet; Warm in nature.Enter bladder; The heart; Lung meridian.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Cure mainly exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; The WEIJIA caking; The thoracic obstruction; Cardiopalmus; Phlegm retention." Changsha medicine solution " carries: " enter liver man and promoting the circulation of blood divides, decide meridians and reach Rong Yu.The kind ailment said due to cold or exposure of separating is transferred wood gas most.The detrapping of sending up the lucid YANG, the punching of the turbid descending the moon is contrary, the anxious contraction of Shujin feeling pulse; The heap soil or fertilizer over and around the roots resistance in sharp joint, loose suppressing, pain relieving Chu, the meridian dredging is opened numbness puckery, very dries cold.End renal mass, more peace palpitation with fear." modern medicine study confirms, Ramulus Cinnamomi effectively blood vessel dilating, promote diaphoresis, that contained cinnamic aldehyde, natrium cinnamicum have is analgesic, analgesia, calmness, anticonvulsant action, in addition Ramulus Cinnamomi antibiotic, antiviral effect in addition..
Rhizoma Alismatis: sweet in the mouth; Light.Cold in nature.Return kidney; Urinary bladder channel.Promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Cure mainly dysuria; The puckery pain of pyretic stranguria; The edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission." not Lu " carries: " the tonifying deficiency five kinds of over strain except the five internal organs feeling of fullness, plays cloudy gas, the stopping leak essence, quenches one's thirst, drenches drop, cuts off the water by bladder, three warmers." the modern medicine study confirmation, Rhizoma Alismatis has cholesterol reducing and comforts Atherosclerosis, improves liver lipid metabolism, and blood sugar lowering, blood pressure affect function of immune system, and serum hemolysin is reduced.
Fructus Ligustri Lucidi: bitter in the mouth; Bitter; Cool in nature.Return liver; Kidney channel.The tonifying liver kidney yin, crow must make eye bright.Cure mainly the hepatic and renal YIN deficiency; Soreness of waist tinnitus; Early whitening of beard and hair; Unseeing; Fever due to yin deficiency." book on Chinese herbal medicine is stated " carries: " Fructus Ligustri Lucidi is real, and though enter sea of blood benefit blood, gentle above flourish ... and to lung, and with about excessive being skillful in, not only beard is for so also by kidney." modern medicine study proves; Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods; heart tonifying, diuresis and hepatoprotective effect are arranged, and the leukopenia quantity that causes because of chemotherapy is raise, and staphylococcus aureus, escherichia coli are had inhibitory action.
Rhizoma Chuanxiong: acrid in the mouth; Warm in nature.Return liver; Gallbladder; Pericardium channel.Blood circulation promoting and blood stasis dispelling; Activating QI to alleviate the depression; Wind-expelling pain-stopping.Zhu Zhi WEIJIA lump; Have a headache dizzy; Anemofrigid-damp arthralgia; Ulcer sores." book on Chinese herbal medicine just " carries: " dispersing wind and cold is controlled pain, and removing blood stasis with potent drugs holds, and promoting blood circulation is separated stagnation of QI, and by pain, the evacuation of pus detumescence is stimulated the menstrual flow by blood." modern medicine scientific research discovery, the Rhizoma Chuanxiong preparation has certain antibacterial action, and contained ligustrazine, ferulic acid are received has blood circulation invigorating efficacies, and expansible coronary artery is promoted coronary flow, allevating angina pectoris, and have anti-thrombosis function; Contained cnidium lactone has the smooth muscle spasmolysis effect in the Rhizoma Chuanxiong.
Periostracum cicadae: sweet in the mouth; Cold in nature; Nontoxic or little poison.Enter lung; Liver Channel.Dispelling wind and heat pathogens; Rash; Relieving spasm by subduing liver-wind; Improving acuity of vision and removing nebula.Cure mainly affection due to external wind and heat; Dizzy; Pharyngalgia; Rash goes out not smooth; Infantile convulsion; Conjunctival congestion and swelling pain; Pterygium." Zhenglei Bencao " carries: " hung infantile convulsion, night cry, cardiopalmus in main day." modern medicine study proves, Periostracum cicadae is rich in mannitol, polysaccharide, aminoacid, cordycepin, adenosine etc., has that the immunity of raising, resisting fatigue, guarantor's kidney are improved sleep, antitumor, protected the liver, radioprotective and a multiple efficacies such as make eye bright.
Poria: sweet in the mouth; Light; Property is put down.Enter the heart; Spleen; Lung; Kidney channel.Eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.Cure mainly dysuria; The edema distension; The phlegm retention cough with dyspnea; Let out wash with watercolours; Palpitation and restlessness; Insomnia forgetfulness; The seminal emission nebulousurine." not Lu " carries: " only quench one's thirst, like to sleep, drench drop, the disease due to obstruction of QI of middle-JIAO expectorant water is opened the breast internal organs, transfers visceral-qi, cuts down the kidney heresy, and is long cloudy, and physical strength profiting is protected during god keeps." the modern medicine study confirmation, Poria all has inhibitory action to staphylococcus aureus, escherichia coli, Bacillus proteus etc., can kill the antibacterials such as leptospira, and digestive system, blood system and central nervous system are had certain protective effect.
Fructus Leonuri: sweet in the mouth; Hot.Cold nature; Upper poison.Return Liver Channel.Promoting blood flow to regulate menstruation; Liver heat removing and eyesight improving.Cure mainly menoxenia; Dysmenorrhea; Amenorrhea; The stasis of blood stagnated and suffered from abdominal pain puerperal; The liver-heat headache; Dizzy; Conjunctival congestion and swelling pain; Order is given birth to cataracta." Bencao Jingshu " carries: " large heat headache is vexed, all the time of blood deficiency and heat also, liver heat removing heat radiation and blood, the vexed all solutions of then having a headache." the modern medicine study confirmation, Fructus Leonuri contains leonurinine alkali, stachydrine, fatty oil, 17 seed amino acids and 24 kinds of mineral elements, and slight hypotensive effect is arranged, and the central nervous system is had the effect of inhibition paralysis.
Radix Saposhnikoviae: acrid in the mouth; Little sweet; Slightly warm in nature.Return lung; Bladder; Liver; Spleen channel.Deliver; Dispel the wind; Win wet; Pain relieving.Cure mainly wind and cold; Folder is wet; Headache; Giddy; Cold-damp; Rheumatic arthralgia; Conjunctival congestion; The hernia abdominal mass." Japan hanako materia medica " carries: " wind as controlling 36, all labor of man are bad, and the invigorating middle warmer benefit is refreshing, blepharitis marginalis, arresting lacrimation and paralysis are slow, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight can tranquilizing the mind, even gaseous pulse." the modern medicine study confirmation, anti-wind energy significantly improves the hypoxia-bearing capability of acute cerebral hypoxia, significantly suppresses the formation of external lipid peroxide of bringing out, and has antioxidant activity, and neurocyte is shielded.
Fructus Lycii: sweet in the mouth; Property is put down.Return liver; Kidney; Lung meridian.Nourishing the liver; Nourishing kidney; Lung moistening.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual one is clear; The taking fluids profusely of quenching one's thirst." book on Chinese herbal medicine just " carries: " improve visual and auditory acuity adds the solid marrow of essence, and the kind impairment caused by overstrain of mending is especially only quenched one's thirst." modern medicine study confirms, Fructus Lycii scalable body's immunity, can establishment tumor growth and cell mutation, effect with slow down aging, anti-fatty liver, adjusting blood fat and the aspects such as blood glucose, promotion hemopoietic function.
Radix Codonopsis: sweet in the mouth; Property is put down.Return spleen; Lung meridian.Strengthening the spleen and tonifying the lung; Supplementing QI for promoting the production of body fluid.Cure mainly weakness of the spleen and stomach; Anorexia and loose stool; Limbs fatigue; The deficiency of the lung is breathed with cough; The spontaneous perspiration of breathing hard; Feeble QI two loses all cards." moral is joined book on Chinese herbal medicine " carries: " the lung heat clearing gold, invigorating primordial QI is opened sound, helps biceps." the modern medicine study confirmation; Radix Codonopsis energy Gastrointestinal motility adjustment, antiulcer, enhancing immunologic function; to excited all influential with two kinds of nervous process of inhibition, rising erythrocyte, hemoglobin, reticulocyte, the in addition effect of slow down aging and antioxidation, radioprotective, blood pressure lowering.
Herba Strobilanthis Japonici: acrid in the mouth; Little hardship.The property little wet.Return liver; Spleen channel.Promoting blood circulation to restore menstrual flow; Blood stasis dispelling row water.Cure mainly menoxenia; Dysmenorrhea; Amenorrhea; Puerperal abdonimal pain; WEIJIA; Body and face edema; Carbuncle." Chinese herbal medicine is commonly used in Sichuan " carries: " soothing liver-QI is loose strongly fragrant for Herba Strobilanthis Japonici, the capable water of repercussive." modern medicine study confirms, Herba Strobilanthis Japonici contains volatile oil, tannin, phenols and several amino acids, can prevent thrombosis, have slight anticoagulant system with the effect that strengthens fibrinolytic, be conducive to the blood clarification of eye blood capillary.
Faeces Vespertilionis: acrid in the mouth; Cold in nature.Enter Liver Channel.Liver heat removing and eyesight improving; The dissipating blood stasis removing food stagnancy.Cure mainly optic atrohic blindness; Nyctalopia; Conjunctival congestion and swelling pain; Subconjuctival hemorrhage; Inside and outside cataracta; Infantile malnutrition; Scrofula." Bencao Jingshu " carries: " except QI and blood in the abdomen, broken cold and heat gather, and except palpitation with fear, get its hot inside and outside knot that can fall apart and stagnate, therefore cold can the heap soil or fertilizer over and around the roots also by dehematize steam." the modern medicine study confirmation, Faeces Vespertilionis contains carbamide, uric acid, cholesterol and a small amount of vitamin A, has the circulation of the ocular blood of improvement, increases optic nerve nutrition, promotes the effects such as ocular tissue's metabolism.
The present invention compared with prior art has following beneficial effect:
Prescription compatibility of the present invention is reasonable, for the card of the wind-heat of liver channel that causes ophthalmic, liver-wind deficiency-heat, stagnation of blood stasis, take nourishing blood to expel wind, heat radiation nebula removing as aim, dredging eye blood capillary, promote local blood circulation, increase optic nerve nutrition, promote ocular tissue's metabolism, good absorbing effect, evident in efficacy, safe and reliable, without clinical adverse, higher to the cure rate of retrobulbar neuritis disease through clinical verification.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further elaborated.
Embodiment 1
The raw material of pill effective ingredient of the present invention forms and weight is:
Radix Glycyrrhizae 57g Radix Angelicae Sinensis 55g Rhizomadioscoreae 52g Cortex Moutan 49g
Ramulus Cinnamomi 47g Rhizoma Alismatis 43g Fructus Ligustri Lucidi 40g Rhizoma Chuanxiong 38g
Periostracum cicadae 30g Poria 28g Fructus Leonuri 26g Radix Saposhnikoviae 22g
Fructus Lycii 21g Radix Codonopsis 19g Herba Strobilanthis Japonici 15g Faeces Vespertilionis 12g
The processing step of pill preparation method of the present invention is:
(1) Radix Angelicae Sinensis, Periostracum cicadae are ground into powder after pulverizing, crossed 200 order fine powders, for subsequent use.
(2) Rhizomadioscoreae, Fructus Lycii are put into container, smash as medicine mud, for subsequent use.
(3) with Herba Strobilanthis Japonici enriching brown sugar water, after the slow fire fried dry, grind into powder, cross 120 order fine powders, for subsequent use.
(4) Rhizoma Alismatis is stir-fried for several times with slow fire, even with the wine spray, fried dry is ground into powder, crosses 120 order fine powders, and is for subsequent use.
(5) Faeces Vespertilionis is wrapped with crocus cloth, put into container with Radix Glycyrrhizae, Cortex Moutan, Ramulus Cinnamomi, Fructus Ligustri Lucidi, Fructus Leonuri, Radix Saposhnikoviae, add the water of six times of amounts, soak after 6~7 hours, get immersion; The water that adds again four times of amounts in remaining medicinal residues soaked after 4~5 hours, got immersion; Merge twice gained immersion, the thick paste of relative density 1.15~1.20 is for subsequent use under 70 ℃ of environment of simmer down to.
(6) Rhizoma Chuanxiong, Poria, Radix Codonopsis are put into container, add the yellow wine of six times of amounts, boil rear immersion 2~3 hours, get and boil liquid; The yellow wine that adds again triplication in remaining medicinal residues soaked under the room temperature 2~3 hours, got and boiled liquid; Merge twice gained and boil liquid, the thick paste of relative density 1.10~1.15 is for subsequent use under the simmer down to room temperature environment.
(7) fine powder of step (1), step (3), step (4) gained, the medicine mud of step (2) gained are mixed with the thick paste of step (5), step (6) gained, the rear adding Mel that stirs is prepared as the pill of 9g/ grain.
Usage and dosage: every day 3 times, each 1, take with hot brown sugar water after meal, 9 days is a course for the treatment of, and common 2~3 courses for the treatment of are effective, and pertinacious disease needs 4~6 courses for the treatment of.
Embodiment 2
The raw material of pill effective ingredient of the present invention forms and weight is:
Radix Glycyrrhizae 53g Radix Angelicae Sinensis 51g Rhizomadioscoreae 49g Cortex Moutan 46g
Ramulus Cinnamomi 43g Rhizoma Alismatis 39g Fructus Ligustri Lucidi 37g Rhizoma Chuanxiong 35g
Periostracum cicadae 28g Poria 27g Fructus Leonuri 24g Radix Saposhnikoviae 21g
Fructus Lycii 20g Radix Codonopsis 18g Herba Strobilanthis Japonici 13g Faeces Vespertilionis 11g
Pill preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
The raw material of pill effective ingredient of the present invention forms and parts by weight are:
Radix Glycyrrhizae 51g Radix Angelicae Sinensis 49g Rhizomadioscoreae 44g Cortex Moutan 42g
Ramulus Cinnamomi 39g Rhizoma Alismatis 36g Fructus Ligustri Lucidi 34g Rhizoma Chuanxiong 31g
Periostracum cicadae 27g Poria 26g Fructus Leonuri 22g Radix Saposhnikoviae 20g
Fructus Lycii 19g Radix Codonopsis 17g Herba Strobilanthis Japonici 12g Faeces Vespertilionis 9g
Pill preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
Pill of the present invention is multiplex in the auxiliary treatment means of retrobulbar neuritis clinically, especially be applicable to the little operation of eye recovery afterwards, the clinical treatment tracking data shows, look in pipe lower inner wall excision patient's the clinical care in 37 examples, the retrobulbar neuritis cure rate of taking pill of the present invention reaches 62%, total effective rate reaches 86%, satisfies the drug effect standard of retrobulbar neuritis specific drug on the clinical ophthalmology fully.